Glodé 10/14 LEONARD MICHAEL GLODÉ, M.D. Business Address Urologic Oncology Anschutz Outpatient Pavilion 1665 Aurora Court Suite 1004 - Campus Box F710 Aurora, CO 80045 Office Telephone: (720) 848-2543 Email: Mike.Glode@ucdenver.edu Place of Birth Chadron, NE Citizenship USA Marital Status Married, 1969 to Mary Patricia Rose Glodé, M.D., 3 children Education 1965 1965-1968 1972 Certification 1973 1975 1981 Chadron High School, Chadron, Nebraska, Valedictorian University of Nebraska, Lincoln, NE; Zoology Major Washington University School of Medicine, St Louis, MO Degree: M.D. National Board of Medical Examiners (Cert. No. 123284) American Board of Internal Medicine (Cert. No. 51200) American Board of Internal Medicine, Medical Oncology Subspecialty Professional Experience 1972 Parkland Memorial Hospital Straight Medical Intern, Parkland Memorial Hospital, Dallas, Texas 1973 University of Texas Southwestern Medical School Straight Medical Resident, University of Texas Southwestern Medical School, Dallas, Texas 1974-1976 Laboratory of Microbiology and Immunology Research Associate, NIH, NIDR, Laboratory of Microbiology and Immunology, Bethesda, Maryland 1976-1978 Harvard Medical School Fellow in Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 1978-1983 University of Colorado Health Sciences Center Assistant Professor of Medicine, Division of Medical Oncology, University of Colorado Health Sciences Center, Denver, Colorado 1983-1991 University of Colorado Health Sciences Center 1 Glodé 10/14 1986-1987 1991-Present Associate Professor of Medicine, Division of Medical Oncology, University of Colorado Health Sciences Center, Denver, Colorado University of Helsinki Fogarty Fellow in Molecular Biology, University of Helsinki University of Colorado Health Sciences Center Professor of Medicine, Division of Medical Oncology, University of Colorado Health Sciences Center, Denver, Colorado Military Service 1974-1976 U.S. Public Health Service 1976-1994 USPHS Reserve Licenses 1975 Maryland 1976 Massachusetts 1978 Colorado Societies Theta Nu (premedical honorary fraternity) Alpha Omega Alpha (medical honorary) American Society of Clinical Oncology American Association for Cancer Research Western Society for Clinical Investigation Western Association of Physicians American College of Physicians Honors 1965-1968 1968-1969 1969-1970 1970-1971 1970-1971 1971-1972 1980-1982 1982 1986-1987 1993-2005 1996-2006 1998 1999 20002003 2003 2008 2008 Deans List, University of Nebraska (4.0 cumulative average) Richard G. Brookings Prize for Academic Excellence (Washington University School of Medicine) Roche Award (Washington University School of Medicine) Richard G. Brookings Prize (Washington University School of Medicine) Merck Award (Washington University School of Medicine) Alpha Omega Alpha Book Award (Washington University School of Medicine) American Cancer Society Junior Faculty Clinical Fellow Invited Speaker, ACS Science Writer's Seminar Fogarty Senior International Fellow, Molecular Biology, University of Helsinki Best Doctors in America Best Doctors in America, Medical Advisory Board Excellence in Teaching Award, Medical Student Council, The University of Colorado School of Medicine University of Colorado Innovations in Teaching Award, HSC Campus Robert Rifkin Chair for Prostate Cancer Research Excellence in Teaching Award, The University of Colorado School of Medicine Class of 2003 Board of Directors Appreciation Award, American Society Clinical Oncology Statesman Award, American Society of Clinical Oncology Fellow, American College of Physicians 2 Glodé 10/14 Committees/Administration/Education 1. Medical Director, Gene Therapy Program 1990-96 2. Organizer, American Association of Cancer Research Workshop, "Molecular Biology for Clinical Oncologists, July 1992-2000 3. Course Director, Med 6622 Medical School Curriculum, 1987-1995 4. Medical Director, Prostate Research Clinic 1996-Present 5. Ad Hoc Member, National Institutes of Health Study Section on Experimental Therapeutics 2 6. Ad Hoc Member, NCI study section for Gene Therapy RFA's 7. Ad Hoc Member, American Cancer Society Study Section on Hematology 8. Internship Selection Committee - 1988-1995 9. Medical Review Committee, W.W. Smith Charitable Trust, Bryn Mawr, PA: 1992-1995 10. Editorial Committee, Annual Review of Medicine: Selected Topics in the Clinical Sciences, 1991. 11. Chair, Molecular Medicine Education Committee, American Society of Clinical Oncology, 1994 12. President, Faculty Senate, University of Colorado School of Medicine 1994-95 13. Vice Chair, ASCO Education Committee, 1994-1995 14. Chair, ASCO Education Committee, 1995-1996 15. Board of Directors, Best Doctors in America, 1997-2002 16. Editor-in-Chief, ASCO Online, 1996-2004 17. Member, Advisory and Oversight Board for Informatics Infrastructure, National Cancer Institute, 1998-2000 18. University Physicians Inc. (UPI) Board of Directors 2001-2003 19. President Elect, Faculty Council, University of Colorado Health Sciences Center, 2001-03 20. Board of Directors, Gonex, Cedus Inc. 1996-Present 21. Course Director, Oncology Section, Med 6000 Pathophysiology, 1998-2003 22. Member, UPI Negotiating Principles Committee, 2001 23. Editorial Board Member, Molecular Cancer Therapeutics, 2001-Present 24. Councilor, Alpha Omega Alpha, Colorado chapter, 2000-2004 25. Faculty, American Society of Clinical Oncology Annual Meetings 1994, 2008,2009 26. President, Faculty Assembly, University of Colorado Health Sciences Center, 2003-2005 27. Editorial Board Member, Cancer Biology & Therapy, 2002-2007 28. Associate Director for Outreach, University of Colorado Cancer Center 200829. Editorial Board, Oncoogy, 2011Reviewer 1996-2003 1998-2001 1998-Present 2001-Present Founding Editor and Editor-in-Chief, ASCO OnLine (http://www.asco.org) Associate Editor, Clinical Cancer Research American Journal of Respiratory and Critical Care Medicine Editorial Board member, Molecular Cancer Therapeutics Ad Hoc Reviewer for Cancer Research, Science, American Review of Respiratory Diseases, Cancer, New England Journal of Medicine, Journal of the National Cancer Institute and Annals of Internal Medicine 3 Glodé 10/14 Patents 1. GnRH Analogs for Destroying Gonadotrophs: 5,378,688 issued Jan. 3, 1995; T M Nett, and L M Glodé 2. Method for Sterilizing Animals using Hormone-Toxin Conjugate Compounds: 5,488,036 issued Jan. 30, 1996; T M Nett, and L M Glodé 3. Hormone-Toxin Conjugate Compounds: 5,492,893 issued Feb. 20, 1996; T M Nett, and L M Glodé 4. Method for Inactivating Gonadotrophs: 5,631,229 issued May 20, 1997; T M Nett, and L M Glodé 5. Method for Treating Cancer: 5,707,964 issued Jan. 13, 1998, T M Nett, and L M Glodé 6. Hormone-Nuclease Compounds and Method for Regulating Hormone Related Diseases: 5,786,457 issued Jul. 28, 1998; T M Nett, L M Glodé and M Karpeisky 7. GnRH-Nuclease Compounds and Method for Regulating Hormone Related Diseases: 6,103,881 issued Aug. 15, 2000; T M Nett, L M Glodé and M Karpeisky 8. Hormone-recombinant toxin compounds and methods for using same, issued Dec 4 2001; T M Nett, L M Glodé, M Wieczorek, and P Jarosz 9. Method for controlling animal populations utilizing a sterilant projectile, 6,419,655, issued Jul 16, 2002; T M Nett and L M Glodé 10. Method for Isolation of Epithelial Cells from a Solution: 6,653,129 issued May 18, 2004; N H Bander, L M Glodé, and C In Suh LIST OF PUBLICATIONS Publications in Peer Reviewed Journals 1. Rosenstreich DL, and Glodé LM: Difference in B cell mitogen responsiveness between closely related strains of mice. J Immunology 115:770-780, 1975. 2. Glodé LM, Scher I, Osborne B, and Rosenstreich DL: Cellular mechanism of endotoxin unresponsiveness in C3H/HeJ mice. J Immunology 116:454-467, 1976. 3. Glodé LM, and Rosenstreich DL: Genetic control of B cell activation by bacterial lipopolysaccharide is mediated by multiple distinct genes or alleles. J Immunology 117:2061-2066, 1976. 4. Rosenstreich DL, Glodé LM, and Mergenhagen SE: The action of endotoxin on lymphoid cells. J Infect Dis 136:S239-245, 1977. 5. Glodé LM, Mergenhagen SE, and Rosenstreich DL: Significant contribution of spleen cells in mediating the lethal effects of endotoxin in vivo. Infection & Immunity 14:626630, 1977. 6. Rosenstreich DL, Glodé LM, Wahl LM, Sandberg AL, and Mergenhagen SE: Analysis of the cellular defect of the endotoxin unresponsive C3H/HeJ mouse. (Am. Soc. Microbiol. Conf. on Endotoxin, Bacterial Antigens, and Host Response). in: Microbiology, D. Schlesinger (ed), Amer. Soc. Microbiol., Washington, D.C., 1977. 7. Glodé LM, Jacques A, Mergenhagen SE, and Rosenstreich DL: Resistance of macrophages from C3H/HeJ mice to the in vitro cytotoxic effects of endotoxin. J Immunology 119:162-166, 1977. 8. Glodé LM, Greene HL, and Bikel I: Cystathionase in normal and leukemic cells. Cancer Treat Rep 63:1081-1088, 1979. 9. Glodé LM, Pitman SW, Ensminger WD, Rosowsky A, Papathanasopoulos N, and Frei E III: A Phase I study of high dose aminopterin with leucovorin rescue in patients with advanced metastatic tumors. Cancer Res 39:3707-3714, 1979. 4 Glodé 10/14 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. Ensminger WD, Rosowsky A, Raso V, Levin DC, Glodé LM, Come S, Steele G, and Frei E III: A clinical-pharmacologic evaluation of hepatic arterial infusions of 5-fluoro-2'deoxyuridine and 5-fluorouracil. Cancer Res 38:3784-3792, 1979. Ryan JL, Glodé LM, and Rosenstreich DL: Lack of responsiveness of C3H/HeJ macrophages to lipopolysaccharide: The cellular basis of LPS stimulated metabolism. J Immunology 122:932-935, 1979. Wahl LM, Rosenstreich DL, Glodé LM, Sandberg AL, and Mergenhagen SE: Defective prostaglandin synthesis by C3H/HeJ mouse macrophages stimulated with endotoxin preparations. Infection & Immunity 23(1):8-13, 1979. Glodé LM: Dose limiting extramedullary toxicity of high dose chemotherapy. Exp. Hematol. 7 (Suppl. 5):265-278, 1979. Glodé LM, Kriegler MP, and Livingston DM: Cysteine auxotrophy of human lymphoblasts is associated with decreased amounts of intracellular cystathionase protein. Biochemistry 20(5):1306-1311, 1981. Glodé LM, Epstein A, and Smith C: Reduced gamma cystathionase protein content in human malignant leukemic cell lines as measured by immunoassay with monoclonal antibody. Cancer Res 41:2249-2254, 1981. Glodé LM, Robinson J, and Gould SF: Protection from cyclophosphamide induced testicular damage by an analogue of gonadotropin releasing hormone. Lancet I:1132-1134, 1981. Hartmann DW, Robinson WA, Mangalik A, Glodé LM, and Triebel F: Unanticipated side effects from treatment with high dose mechlorethamine in patients with malignant melanoma. Cancer Treat Rep 65:327-328, 1981. Hartmann DW, Robinson WA, Morton NJ, Mangalik A, and Glodé LM: High dose nitrogen mustard (NH2) with autologous nonfrozen bone marrow transplantation in advanced malignant melanoma. A Phase I trial. Blut 42:209-220, 1981. Glodé LM, Montgomery RL, Smith CG, and Link D: Use of monoclonal antibody to increase sensitivity and specificity in quantitative immunodiffusion assays. J Immun Methods 48:l3-22, l982. Thomas MR, Robinson WA, Koeppler H, Dantas ME, Glodé LM, Morton NJ: Treatment of advanced malignant melanoma with high dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study. Am J Clin Onc 5:611-622, 1982. Glodé LM, Robinson WA, Hartmann DW, Klein J, Thomas MR and Morton NJ: Autologous bone marrow transplantation in the therapy of small cell carcinoma of the lung. Cancer Res 42:4270-4275, 1982. Glodé LM, Robinson J, Gould SF, Nett TM, and Merrill D: Protection of spermatogenesis during chemotherapy. Drugs in Exptl Clin Res VIII(4):367-378, 1982. Link D, Drebing C, and Glodé LM: Cystathionase: A potential cytoplasmic marker of hematopoietic differentiation. Blut 47:31-39, 1983. Gould SF, Powell D, Nett T, and Glodé LM: A rat model for chemotherapy induced male infertility. Arch Andrology 11:141-150, 1983. Dantas ME, Brown JP, Thomas MR, Robinson WA, and Glodé LM: Detection of melanoma cells in bone marrow using monoclonal antibodies: a comparison of fluorescence activated cell sorting (FACS) and conventional immunofluorescence (IF). Cancer 52(6);949-953, 1983. Chitambar CR, Robinson WA, and Glodé LM: Familial leukemia and aplastic anemia associated with monosomy 7. Am J Med 75:756-762, 1983. 5 Glodé 10/14 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. Geier JM, Braun TJ, Gross CE, Kindt GW, and Glodé LM: Extracerebral toxicity of continuous intracarotid 2'deoxy-5-fluorouridine via implanted Infusaid 400 pump in brain tumor patients. Surg Forum 34:530-533, 1983. Garnick MB and Glodé LM: (Writing Committee for the Leuprolide Study Group): Leuprolide versus diethylstilbestrol for metastatic prostate cancer. N Eng J Med 311:1281-1285, 1984. Thomas MR, Robinson WA, Koeppler H, Dantas M, Drebing C, and Glodé LM: Autologous marrow transplantation for patients with chronic myelogenous leukemia (CML) in blast crisis. Am J Hemat 16:105-112, 1984. Santen RJ, Demers LM, Max DT, Smith J, Stein BS, and Glodé LM: Long-term effects of administration of a gonadotropin-releasing hormone super agonist analog in men with prostatic carcinoma. J Clin Endo & Metab 58:397-400, 1984. Manni A, Santen RJ, Boucher A, Lipton A, Harvey H, Drago J, Rohner T, Haagensen D, Glodé LM, and Santner SJ: Evaluation of CEA and GCDFP-15 plasma level during hormonally induced cancer stimulation. Anticancer Res 4:141- 144, 1984. Thomas MR, Robinson WA, Mughal TI, and Glodé LM: Tumor lysis syndrome following VP-16-213 in chronic myeloid leukemia in blast crisis. Amer J Hemat 16:185-188, 1984. Glodé LM, Robinson J, and Horwitz LD: Scrotal hypothermia and testicular blood flow in the dog - absence of thermal regulation. J Androl 5:227-229, 1984. Manni A, Santen RJ, Boucher A, Lipton A, Harvey H, Simmonds M, White D, Gordon R, Ronher T, Drago J, Wettlaufer J, and Glodé LM: Hormone stimulation and chemotherapy in advanced prostate cancer: Preliminary results of a prospective controlled clinical trial. Anticancer Res 5(2):161-165, 1985. Smith Jr. JA, Glodé LM, Wettlaufer JM, Stein BS, Glass AG, Max DT, Anbar D, Jagst CL, and Murphy GP: Clinical effects of a gonadotropin-releasing hormone analogue in metastatic carcinoma of prostate. Urology 25:106-114, 1985. Garnick MB, Glodé LM, Smith JA, and Max D (for the Leuprolide Study Group): Leuprolide: A review of its effects in comparison with diethylstil boestrol in the treatment of advanced cancer of the prostate. Brit J Clin Prac 39:73-76, 1985. Montgomery RR, Kunicki TJ and Glodé LM: Use of monoclonal antibody to increase the sensitivity and specificity of precipitating immunoassays and cell surface binding immunoassays. Methods in Enzymology 121:702-717, 1986. Glodé LM: The biology of gonadotropin-releasing hormone and its analogs. J Urology 27:16-19, 1986. Mughal T, Glodé LM, Smith H, Geyer JM, Braun T, Klingensmith W, and Kindt G: Phase I clinical trial of intracarotid bis-chloroethylnitrosoureas (BCNU) and 2' dioxy-5fluorouridine (FUDR) in malignant astrocytomas. J Neuro Onc 3:291-296, 1986. Thomas MR, Robinson WA, Mughal T, Morton N, and Glodé LM: Recovery of blood and bone marrow stem cells following intense chemotherapy and autologous bone marrow transplantation. Oncology 43:273-277, 1986. Maxwell IH, Maxwell F and Glodé LM: Regulated expression of a diphtheria toxin Achain gene transfected into human cells: A possible strategy for inducing cancer cell suicide. Cancer Res 46:4660-4664, 1986. Braunschweiger PG, Glodé LM, Maring EM, Machus K, and Reynolds BV: Biologic implications of androgen dependent changes in proton-NMR relaxation times in rat ventral prostate. The Prostate 9:283-294, 1986. 6 Glodé 10/14 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. Manni A, Santen RJ, Boucher AE, Lipton A, Harvey H, Simmonds M, White-Hershey D, Gordon RA, Rohner TJ, Drago J, Wettlaufer J, and Glodé LM: Androgen priming and response to chemotherapy in advanced prostate cancer. J Urol 136:1242-1246, 1986. Manni A, Santen R, Boucher A, Lipton A, Harvey A, Simmonds M, White-Hershey D, Gordon R, Rohner T, Drago J, Wettlaufer J, and Glodé LM: Hormone stimulation and chemotherapy in advanced prostate cancer: Interim analysis of an ongoing randomized trial. Anticancer Res 6(2):309-314, 1986. Manni A, Santen RJ, Boucher A, Lipton A, Harvey H, White D, Simmonds M, Gordon R, Rohner T, Drago J, Wettlaufer J, Glodé LM: Androgen priming and chemotherapy in advanced prostate cancer. J Endo Invest 10(2):32, 1987. Glodé LM and Smith JA: Long-term suppression of luteinizing hormone, follicle stimulating hormone and testosterone by daily administration of leuprolide. J Urol 137:5760, 1987. Maxwell F, Maxwell IH, and Glodé LM: Cloning, sequence determination, and expression in transfected cells of the coding sequence for the tox 176 attenuated diphtheria toxin A chain. Mol and Cell Biol 7:1576-1579, 1987. Breitman ML, Clapoff S, Rossant J, Tsui L-C, Glodé LM, Maxwell IH, and Bernstein A: Genetic ablation: Targeted expression of a diphtheria toxin gene causes microphthalmia transgenic mice. Science 238:1563-1565, 1987. Klein CE, Roberts B, Holcenberg J and Glodé LM: Cystathionine metabolism in neuroblastoma. Cancer 62:291-296, 1988. Manni A, Bartholomew M, Caplan R, Boucher A, Santen R, Lipton A, Harvey H, Simmonds M, White-Hershey D, Gordon R, Rohner T, Drago J, Wettlaufer J and Glodé LM: Androgen priming and chemotherapy in advanced prostate cancer. Evaluation of determinants of clinical outcome. J Clin Onc 6:1456-1466, 1988. Glodé LM, Shannon JM, Malik N, Nett T: Protection of rat spermatogenic epithelium from damage induced by procarbazine chemotherapy. Br J Cancer 62:61-64, 1990. Erickson PF, Maxwell IH, Su L-J, Baumann M, and Glodé LM: Sequence of cDNA for rat cystathionine gamma lyase and comparison of deduced amino acid sequence with related Escherichia coli enzymes. Biochemical Journal 269(2):335-340 1990. Hemila H, Glodé LM, Palva I: Production of diphtheria toxin CRM228 in B. subtilis. FEMS Microbiology Letters 65:193-198, 1990. Fisher KS, Maxwell IH, Murphy JR, Collier J and Glodé LM: Construction and expression of plasmids containing mutated diphtheria toxin A-chain-coding sequences. Infection and Immunity 59:3562-3565, 1991. Harrison GS, Maxwell F, Long CS, Rosen CA, Glodé LM and Maxwell IH: Activation of a diphtheria toxin A gene by expression of human immunodeficiency virus-1 Tat and Rev proteins in transfected cells. Human Gene Therapy 2:53-60, 1991 Maxwell IH, Glodé LM, Maxwell F: Expression of the diphtheria toxin A-chain coding sequence under the control of promoters and enhancers from immunoglobulin genes as a means of directing toxicity to B-lymphoid cells. Cancer Res 51: 4299-4304, 1991. Kendall SK, Saunders TL, Long J, Ricardo V, Glodé LM, Nett TM, Keri RA, Nilson JH, Camper SA: Targeted Ablation of Pituitary Gonadotropes in Transgenic Mice. Mol Endo 5: 2025-2036, 1991. Mohler JL, Gomella GL, Crawford ED, Glodé LM, Zippe CD, Fair WR, Marshall EM: Phase II evaluation of Coumarin (1,2-Benzopyrone) in metastatic prostatic carcinoma. The Prostate 20:123-131, 1992. 7 Glodé 10/14 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. Maxwell IH, Glodé LM, Maxwell F: Expression of diphtheria toxin A-chain in mature Bcells: A potential approach to therapy of B-lymphoid malignancy. Leukemia and Lymphoma 7: 457-462, 1992. Harrison GS, Long CJ, Maxwell F, Glodé LM and Maxwell IH: Inhibition of HIV production in cells containing an integrated, HIV-regulated Diphtheria toxin A chain gene. Aids Research and Human Retroviruses 8:39-45, 1992. Klein CE and Glodé LM: Options for preserving fertility in the chemotherapy patient. Contemporary Oncology 48-56, 1993. Sher CM, Crawford ED, Nabors W, Wettlaufer J, Schutz M, Davis M, Majeski S and Glodé LM: Clinical use of FUDR in the treatment of metastatic renal cell carcinoma. Cancer Research, Therapy and Control 4:57-60, 1994. Cook DR, Maxwell IH, Glodé LM, Maxwell F, Stevens JO, Wagner E, Curiel DT and Curiel TJ: Gene therapy for B-cell lymphoma in a SCID mouse model using an immunoglobulin-regulated diphtheria toxin gene delivered by a novel adenoviruspolylysine conjugate. Cancer Biotherapy 9:131-141, 1994. Glodé LM: The molecular bridge to gene therapy. Urology 44(6A):81-88, 1994. Walsh P, Dorner A, Duke, Richard C., Su L-J and Glodé LM: Macrophage colonystimulating factor (M-CSF): A candidate gene for gene therapy of metastatic melanoma. Journal National Cancer Institute 87(11):809-816, 1995. Glodé LM: Challenges and opportunities of the internet for medical oncology. Journal of Clinical Oncology 14(7):2181-2186, 1996. Harrison GS and Glodé LM: Current challenges of gene therapy for prostate cancer. Oncology 11(6):845-856, 1997. Lidor YJ, Lee WE, Nilson JH, Maxwell IH, Su L-J, Brand E and Glodé LM: In-vitro expression of the diphtheria toxin A-chain gene under the control of human chorionic gonadotropin gene promoters as a means of directing toxicity to ovarian cancer cell lines. American Journal of Obstetrics and Gynecology 177:579-585, 1997. Reid MB and Glodé LM: Flutamide induced lupus. Journal of Urology 159:2098, 1998. Gleave ME, Higano C, Glode LM, Goluboff E, Pummer K, and Crawford ED: New Horizons in the Management of Hormone-Refractory Prostate Cancer. Reviews in Urology 2, 4S; 40-48, 2000. Hardy PA, Mazzini MJ, Schweitzer C, Lundstrom K and Glodé LM: Recombinant Semliki Forest Virus infects and kills human prostate cancer cell lines and prostatic duct epithelial cells ex vivo. International Journal of Molecular Medicine 5:241-245, 2000. Suh CI, Shanafelt T, May DJ, Shroyer KR, Bobak JB, Crawford ED, Miller GJ, Markham N and Glodé LM: Comparison of telomerase activity and GSTP1 promoter methylation in ejaculate as potential screening tests for prostate cancer. Molecular and Cellular Probes 14:211-217, 2000. Walsh P, Gonzalez R, Dow S, Elmslie R, Potter T, Glodé LM, Baron AE, Balmer C, Easterday K, Allen J, Rosse P: A phase I study using direct combination DNA injections for the immunotherapy of metastatic melanoma. University of Colorado Cancer Center Clinical Trial. Human Gene Therapy 11:1355-1368, 2000. Vaishampayan U, Glodé M, Du W, Kraft A, Hudes G, Wright J, Hussain M. Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma. Clin Cancer Res 6(11):4205-4208, 2000. Olsen E, Duvic M, Frankel A, Kim Y, Martin A, Vonderheid, E, Jegasothyu B, Wood G, Gordon M, Heald P, Oseroff A, Pinter-Brown L, Bowen G, Kuzel T, Fivenson D, Foss, F, 8 Glodé 10/14 76. 77. 78. 79. 80. 81. 82. 83. 84. 85. 86. 87. 88. 89. 90. Glodé M, et al: Pivotal phase III trial of two dose levels of DAB389IL-2 (ONTAK®) for the treatment of cutaneous T-cell lymphoma. J Clin Oncol. Jan 15;19(2):376-88, 2001. Simmons PD, Hines S, Harrison GS, Murphy JR and Glodé LM: Internet-based survey of physician attitudes regarding prostate cancer screening and treatment. Cancer Research, Therapy and Control, 2001. Mazzini MJ and Glodé LM: Internet Oncology: Increased benefit and risk for patients and oncologists. Hematology/Oncology Clinics of North America 15(3):583-592, 2001. Tomera K, Gleason D, Gittelman M, Moseley W, Zinner N, Murdoch M, Campion M and Garnick M for the Abarelix Study Group: Abarelix Depot-M, a GnRH antagonist vs leuprolide or goserelin, LHRH superagonists: Results of endocrinologic and biochemical efficacy in patients with prostate cancer. Urology 165 (5): 1585-1589, 2001. Crawford ED, Miller GJ, Labrie F, Hirano D, Batuello J, and Glodé LM: 11th international prostate cancer update: Prostate cancer pathology, screening and epidemiology. Reviews in Urology, 3 (suppl 2): S2-S10, 2001. Goluboff ET, Hirano D, Thrasher JB, Stark G, Miller GJ, Glodé LM: New approaches to the treatment of advanced prostate cancer. Reviews in Urology 3 (suppl 2): S69-S78, 2001. Zinelabidine A, Miller GJ, Glodé LM, Akduman B, Donohue RE, Nedrow A, Crawford ED: High Gleason scores and lower prostate-specific antigen levels in a single institution over the past decade. Clinical Prostate Cancer 1(1): 2002. Whitehead RP, Lew D, Flanigan RC, Weiss GR, Roy V, Roy V, Glodé LM, Dakhil SR and Crawford ED: Phase II trial of recombinant human interleukin-4 in patients with advanced renal cell carcinoma: A Southwest Oncology Group study. Journal of Immunotherapy 25(4):352-358, 2002. Abouelfadel Z, Miller GJ, Glodé LM, Akduman B, Donohue R, Nedrow A, Crawford ED: High Gleason scores and lower prostate-specific antigen levels in a single insitution over the past decade. Clinical Prostate Cancer Vol 1, 1(4): 115-117, 2002. Bergen M, Lewis K, Chen R, Kenney T, Glodé LM: Prostate cancer on the internet: impact on patients and how technology helps physicians and researchers. Clinical Prostate Cancer 1(4): 227-234, 2003. Dhanalakshmi S, Agarwal P, Glodé LM and Agarwal R: Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death. Journal of Cancer 106: 699-705, 2003. Glodé LM, Barqawi A, Crighton F, Crawford ED, and Kerbel R: Metronomic therapy with cyclophosphamide and dexamethasone for prostate cancer. Cancer 98 (8): 1643-1648, 2003. Skinner EC and Glodé LM: High risk localized prostate cancer: Primary surgery and adjuvant therapy. Urologic Oncology 21(3): 219-227, 2003. Qi L, Singh RP, LU Y, Agarwal R, Harrison GS, Franzusoff A, and Glodé LM: Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biology and Therapy 2(5):526-531, 2003. Qi L, Nett TM, Allen MC, Sha X, Harrison GS, Frederick BA, and Glodé LM: GnRH – PAP hormonotoxin targets cytotoxicity to prostate cancer cell lines. Urological Research 31 (6): 374-377, 2003. Qi L, Robinson WA, Brady BMR, Singh R, and Glodé LM: Relationship between expression of VEGF and its receptors to migration and invasion of human prostate cancer cells in vitro. Anticancer Research 23(5A): 3917-22, 2003. 9 Glodé 10/14 91. 92. 93. 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. Tyagi AK, Agarwal C, Singh RP, Shroyer KR, Glodé LM,and Agarwal R: Silibinin downregulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. Biochemical and Biophysical Research Communications 312: 1178-1184, 2003. Qi L, Nett TM, Allen MC, Sha X, Harrison GS, Frederick BA, Crawford ED, and Glodé LM: Binding and cytotoxicity of conjugated and recombinant fusion proteins targeted to the GnRH receptor. Cancer Research 64: 2090-2095, 2004. Fung KY, Glodé LM, Green S, and Duncan M: A comprehensive characterization of the peptide and protein constitutents of human seminal fluid. The Prostate 61(2): 171-181, 2004. Ziada A, Barqawi A, Glode LM, Varella-Garcia M, Crighton F, Majeski S, Rosenblum M, Kane M, Chen L, and Crawford ED: The use of trastuzumab in the treatment of hormone refractory prostate cancer; phase II trial. Prostate. 60(4): 332-337, 2004. Tyagi A, Agarwal C, Harrison G, Glodé LM, and Agarwal R: Silibinin causes cell cycle arrest in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis 12(9): 1711-1720, 2004. Harrison GS, Wierman MA, Nett TM, and Glodé LM: GnRH and its receptor in normal and malignant cells. Endocr. Related Cancer 11: 725-748, 2004. Yang W-H, Allen MC, Wieczorek M, Glodé LM, and Nett TM: A sandwich enzyme-linked immunoabsorbent assay for measurement of gonadotropin-releasing hormone toxin, Amer J. Reprod. Immunol. 55: 208-216, 2006. L.M. Glode and M. Lindquist: The case for adjuvant therapy of prostate cancer, Prostate Cancer Supplement, J. Urol. S30-3, 2006. Denberg T, Glode M, Steiner J, Crawford D, Hoffman R: Trends and predictors of aggressive therapy for clinical locally advanced prostate carcinoma. BJU International 10.111, 2006. Grossman HB, Tangen CM, Cordon-Cardo C, Cote R, Waldman FM, De Vere White RW, Karnad AB, Glode M, and Crawford ED: Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: a Southwest Oncology Group Study. Oncol. Rep. 16(4): 807-810, 2006. Flaig TW, Barqawi A, Miller G, Kane M, Zeng C, Crawford ED, and Glodé LM: A phase II trial of dexamethasone, vitamin D and carboplatin in patients with hormone refractory prostate cancer. Cancer 107(2):266-274, 2006. Flaig TW, Nordeen SK, Lucia S, Harrison G, and Glodé LM.: Conference Report: Current status of biomarkers potentially associated with prostate cancer outcomes. J. Urol, Apr;177(4):1229-37, 2007. Flaig TW, Su Lih-Jen, Agarwal R, and Glodé LM: Silibin synergizes with mitoxantrone to inhibit cell growth via apoptosis in prostate cancer cells. Int. J. Cancer May 1;120(9): 2028-33, 2007. Flaig TW, Gustafson DL, Su L, Zirrolli J, Harrison G, Pierson AS, Agarwal R, and Glodé LM: A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer. Investigational New Drugs Apr;25(2):139-46. Epub 2006 Nov 1, 2007. Arthur C, Flaig T, Su L, Denney R, Barnes F, and Glodé LM: The effect of ultrasonic irradiation on adriamycin-induced cytotoxicity in three human bladder cancer cell lines. Ultrasonics Mar;46(1):68-73. Epub 2006 Nov 27, 2007. M. Hussain, G. R. MacVicar, D. Petrylak, R. Dunn, U. Vaishampayan, P.N. Lara, Jr, G. Chatta, D. Nanus, L.M. Glode, D. Trump, H. Chen, and D.C. Smith: Trastuzumab, 10 Glodé 10/14 107. 108. 109. 110. 111. 112. 113. 114. 115. 116. 117. 118. Paclitaxel, Carboplatin, and Gemcitabine In Advanced Her-2/neu Positive Urothelial Carcinoma: Results of a Multi-Center Phase II NCI Trial. J. Clin. Oncol., Jun 1:25(16): 2218-24, 2007. Tyagi A, Raina K, Singh RP, Gu M, Agarwal C, Harrison G, Glode LM, and Agarwal R: Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice .Mol Cancer Ther., Dec;6(12):3248-55, 2007. Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glodé LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, and Agarwal R.:Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res, Nov 15;67(22):11083-91, 2007 Flaig T, Crawford ED, Kavanagh B, Lucia S, La Rosa F, Barqawi A, Crighton F and Glodé LM.: Prostate cancer in a man with multiple previous cancers, Oncology (Williston Park), Apr;21(5):611-4, 2007. Flaig TW, Tangen CM, Hussain MH, Stadler WM, Raghavan D, Crawford ED, Glode LM: Randomization reveals unexpected acute leukemias in Southwest Oncology Group prostate cancer trial. J Clin Oncol, Mar 20:26(9):1532-36, 2007. Glode LM, Metabolic syndrome and prostate cancer. Cancer, May 15;112(10):2188-94, 2008. Attia S, Eickhoff J, Wilding G, McNeel D, Blank J, Ahuja H, Jumonville A, Eastman M, Shevrin D, Glode M, Alberti D, Staab MJ, Horvath D, Straus J, Marnocha R, Liu G: Randomized, double-blinded phase II evaluation of docetaxel with or without doxercalciferol in patients with metastatic, androgen-independent prostate cancer. Clin Cancer Res Apr 15;14(8):2437-43, 2008. Flaig TW, Glode LM.: Management of the side effects of androgen deprivation therapy in men with prostate cancer. Expert Opin Pharmacother. Nov;9(16):2829-41, 2008. Flaig TW, Glodé LM, Gustafson D, Van Bokhoven A, Tao Y, Yuzhen T, Wilson S, Su L-J, Yuan L, Harrison G, Agarwal R, Crawford ED, Lucia S, Pollak M: A Pilot Study of HighDose Oral Silybin-Phytosome Followed by Prostatectomy in Patients with Localized Prostate Cancer. The Prostate, Jun 1;70(8): 848-55, 2010. Kantoff PW, Schuetz TJ, Blumenstein BA, Glodé LM, Bilhartz DL, Wyand SM, Manson K, Panicali DL, Laus R, Schlom J, Dahut WL, Arlen PM, Gulley J, Godfrey WR: Overall survival (OS) analysis of a Phase II randomized controlled trial (RCT) of a poxviral-based PSA targeted immunotherapy in metastatic castration-resistant prostate cancer (mCRPC). Journal Clinical Oncoglogy. Mar 1;28(7): 1099-105, 2010. Stinauer MA, Kavanagh BD, Schefter TE, Gonzalez R, Flaig T, Lewis K, Robinson W, Chidel M, Glode M, Raben D: Stereotactic body radiation therapy for melanoma and renal cell carcinoma: impact of single fraction equivalent dose on local control. Radiat Oncol. Apr 8; 6:34, 2011 Dorff TB, Flaig TW, Tangen CM, Hussain MH, Swanson GP, Wood DP Jr, Sakr WA, Dawson NA, Haas NB, Crawford ED, Vogelzang NJ, Thompson IM, Glode LM: Adjuvant androgen deprivation for high-risk prostate cancer after radical prostatectomy: SWOG S9921 study. J Clin Oncol. May 20;29(15):2040-5. Epub 2011 Apr 18, 2011. Beer TM, Bernstein GT, Corman JM, Glode LM, Hall SJ, Poll WL, Schellhammer PF, Jones LA, Xu Y, Kylstra JW, Frohlich M: Randomized Trial of Autologous Cellular Immunotherapy with Sipuleucel-T in Androgen-Dependent Prostate Cancer. Clin Cancer Res. Jul 1;17(13):4558-4567, 2011. 11 Glodé 10/14 119. 120. 121. 122. 123. 124. 125. 126. 127. 128. 129. 130. 131. 132. 133. 134. Clemons J, Glodé LM, Gao D, Flaig TW: Low-dose diethylstilbestrol for the treatment of advanced prostate cancer. Urol Oncol. Jul 25. [Epub ahead of print], 2011. Wilson SS and Glode, LM. Appropriate use of Androgen Deprivation Therapy in the Treatment of Prostate Cancer in the Modern Era. AUA Update Series, 2011 (submitted). Werahera PN, Glode LM, La Rosa FG, Lucia MS, Crawford ED, Easterday K, Sullivan H, Sidhu RS, Genova E, Hedlund T: Proliferative tumor doubling times of prostatic carcinoma. Prostate Cancer, Vol. 2011, Art.301850, 2011. Doi:10.115/2011/301850. Lam ET, La Rosa FG,Suby-Long TD, Kondo KL, Wilson S, Glode LM, Flaig TW: A rare case of metastatic renal epithelioid angiomyolipoma. Oncology Aug;25(9):832-8, 2011. Amato RJ, Glode LM, Podolnick J, Knight R, Crawford ED: Phase II study of pomalidomide in patients with castration-resistant prostate cancer. Cancers, (3)3449-60, 2011. Marsland T, Arena F, Yeilding A, Glodé M, Ellis L, Yu J, Henderson C, Wagman L, Piver S, Minsky B, Rosen S, Poplack D, Potters L, Crawford D, Hoskins W: Perspective on...the new PSA screening recommendations. Oncology, 2011 Nov 15;25(12):1183, 1187-8, 1190. Chaudhry A, Glodé LM, Gillman M, Miller RS: Trends in twitter use by physicians at the american society of clinical oncology annual meeting, 2010 and 2011. J Oncol Pract. 2012 May;8(3):173-8. Epub 2012 Apr 17. Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K, Flaig TW, Affirm Investigators- Glode LM: Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012 Sep 27;367(13):1187-97. Epub 2012 Aug 15. Xiaoping Yang1,7, Lih-Jen Su1,7, Andrew Thorburn2,7, Arthur E. Frankel3, Yuan Li1, 4, Francisco G. La Rosa5,7, Elizabeth Kessler1, Jingping Shen6,7, Chuan-Yuan Li6,7, Marileila Varella-Garcia1,7, L. Michael Glodé1,7, Thomas W. Flaig: Diphtheria Toxin-Epidermal Growth Factor Fusion Protein DAB389EGF for the treatment of bladder cancer. Clin Cancer Res. 2013 Jan 1;19(1):148-57. Lam ET, Glode LM: Neoadjuvant and adjuvant hormonal and chemotherapy for prostate cancer. Hematology Oncology Clinics of North America. 2013 Dec;27(6):1189-204. Glode LM, Lam ET: Nonseminomatous germ cell tumor of testis and interrupted treatment. Oncology. 2013 Aug;27(8):822-3. Beer TM, Schellhammer PF, Corman JM, Glode LM, Hall SJ, Whitmore JB, Frohlich MW, Penson DF: Quality of life after sipuleucel-T therapy: results from a randomized, doubleblind study in patients with androgen-dependent prostate cancer. Urology. 2013 Aug;82(2):410-5. Dorff TB, Glode LM: Current role of neoadjuvant and adjuvant systemic therapy for highrisk localized prostate cancer. Curr. Opinion Urology. 2013 Jul;23(4):366-71. Lam, E, Glode, LM: Neoadjuvant and adjuvant hormonal and chemotherapy for prostate cancer. Hematology Oncology Clinics of North America. 2013, 27:1189-1204 Schlaepfer I, Rider, L, Rodrigues L, Gijon M, Pac C, Romero L, Cimic A, Sirintrapun S, Glode LM, Eckel R, Cramer S: Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer. Molecular Cancer Therapies. 2014, 13;2361. Shah K, Sciotto C, Glode LM, Robinson W: A Family with Mastocytosis, Achalasia, GIST Tumors and a Unique Mutation in KIT. Submitted. Letters 12 Glodé 10/14 1. 2. 3. 4. 5. Glodé LM: "Gonadal Activity and Chemotherapy-Induced Gonadal Damage." JAMA: Letter #LE8149. 260(14):2064-2065, 1988. Glodé LM: Prostate Cancer Screening. A place for informed consent? Hospital Practice, Editorial, 29(9):8-12, 1994. Glodé LM: PalmPiloting through my life. Oncology Times, page 28, November 2000. Glodé LM: Adjuvant therapy may improve PCa survival outcomes. Urology Times 32(7): 24-25, 2004. Eisenberger M and Glodé LM: Case Reports on Prostate Cancer. Invited Letter Reviews in Urology, 6 (Suppl 7) S39-S45, 2004. Book Chapters 1. Glodé LM: Cytotoxic and immunosuppressive drugs. In: Clinical Use of Drugs in Patients with Kidney and Liver Disease. Anderson, R. and Schrier, R. (eds). W.B. Saunders Co., Philadelphia, PA, pp.260-275, 1981. 2. Robinson WA, Glodé LM: Medical Oncology in Clinical Internal Medicine. Reller, B., Sahn, S., Schrier, S. (eds). 2nd Edition, Little, Brown & Co., Boston, 1982. 3. Glodé LM: Gonadotropin-releasing hormone analogues and other new hormonal treatments of prostate cancer. In: Contemporary Issues in Clinical Oncology, Vol. 5, Genitourinary Cancer, Garnick MB, ed., Churchill Livingston, pp 105-124, 1985. 4. Santen R, English H, Rohner T, Drago J, Lipton A, Harvey H, Simmonds M, Boucher A, Glodé LM, Wettlaufer J, Gordon R and Manni A: Androgen depletion/repletion in combination with chemotherapy: Strategy for secondary treatment of metastatic prostatic cancer. In: European Organization for Research on Treatment of Cancer Monograph No. 2, Alan R. Liss, Inc., New York (F.H. Schroeder, Ed.), pp. 359-371, 1985. 5. Glodé LM: Hodgkin's disease. In: Surgical Secrets. Abernathy C, Abernathy B (eds). Hanley & Belfus Inc., Philadelphia, PA, pp. 190-192, 1986. 6. Manni A, Santen RJ, Boucher AE, Lipton A, Harvey HA, Simmonds MA, White-Hershey D, Gordon RA, Rohner TJ, Drago J, Wettlaufer J, Glodé LM: Androgen priming and chemotherapy in the treatment of advanced prostate cancer. In: New Trends in Diagnosis and Treatment of Prostatic Cancer. Edizioni and Congressi (eds). Acta Medica, p. 235240, 1987. 7. Garnick MB, Lipton A, Max DT, Smith JA, Harvey HA and Glodé LM: Trials with Leuprolide. In: LHRH and its analogs. Contraceptive and theuapeutic applications. Part 2. Boston, MA MTT press ltd., pp. 384-395, 1987. 8. Glodé LM and Scapdino PT: Prostatic carcinoma. In Diseases of the Kidney, Fourth Edition. Schrier, RE and Gottsohalk CW, eds., pp 921-937, 1988. 9. Maxwell IH, Glodé LM, Maxwell F, Harrison GS, Breitman ML, Rombola H, Coulson DM and Bernstein A: Targeted cell suicide by toxin gene expression. In Gene Transfer and Gene Therapy. Alan R. Liss, pp. 189-204,1989. 10. Klein CE, and Glodé LM: Gonadal Complications. In: High-Dose Cancer Therapy. Pharmacology, Hematopoietins, Stem Cells. JO Armitage and KH Antman, eds. Williams and Wilkins, Baltimore, MD, pp 555-568, 1992. 11. Glodé LM, and Klein CE: Complications of cancer and its treatment. Gonadal complications. Cancer Medicine 3rd Edition, Holland JF Frey E, Bast RC, et al (eds). Lea and Febiger, 1992. 12. Glodé LM: Prostatic carcinoma. In Diseases of the Kidney, Fifth Edition. Schrier RE and Gottsohalk CW, eds., pp 921-937, 1992. 13. Klein CE and Glodé LM: Protection of gonadal function. Oncology Times, 1993. 13 Glodé 10/14 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. Klein CE and Glodé LM: Options for preserving fertility in the chemotherapy patient. Contemporary Oncology, pp 48-56, 1993. Glodé LM and Holm C: Prostate. Current Therapy in Cancer, Foley JF, Vose JM and Armitage JO, eds, pp 140-146, 1994. Klein CE and Glodé LM: Options for preserving fertility in the chemotherapy patient. Contemporary Urology, pp 48-56, 1995. Glodé LM: Spirituality in Medical Oncology. American Society of Clinical Oncology Education Book, page 66, 1996. Glodé LM: Cancer information on the world wide web. American Society of Clinical Oncology Education Book, pages 29-33, 1997. Glodé LM and Crawford ED: Prostatic carcinoma. In RW Schrier and CW Gottschalk (eds) Diseases of the Kidney, Sixth Edition. Little, Brown, pages 823-838, 1997. Glodé LM and Petrylak DP: Refractory disease, new horizons and patient-physician relationships. In MK Brawer (ed) Prostate Cancer and Prostatic Diseases. Stockton Press, 5:1-2, 1998. Glodé LM: Early prostate cancer diagnosis and therapy. In RW Schrier, JD Baxter, VJ Dzau, AS Fauci (eds) Advances in Internal Medicine, vol 45. Mosby Inc, pages 41-64, 2000. Glodé LM, Crawford ED, Gleave ME: Prostatic carcinoma. In RW Schrier and CW Gottschalk (eds) Diseases of the Kidney, Seventh Edition. Lippincott Williams & Wilkins, 2001. Glodé LM: Clinical trials in practice. IN JS Silva, MJ Ball, CG Chute, JV Douglas, CP Langlotz, JC Niland, WL Scherlis (eds) Cancer Informatics: Essential Technologies for Clinical Trials. Springer-Verlag, pp 33-43, 2002. Glode LM, Pierson AS, Barqawi AB, Flaig T. Prostate Cancer Diagnosis, Risk Assessment and Management (2 hours of AMA CME). On-line publication: January 19, 2005 (3rd version). www.vlh.com (The Virtual Lecture Hall). Harris S and Glodé LM: Informatics in medical education. Wilson SS, Crawford ED, Glodé LM: Prostatic carcinoma. In RW Schrier and CW Gottschalk (eds) Diseases of the Kidney, Eighth Edition. Lippincott Williams & Wilkins, 2006. Karp D, Blum R, Hudism C, Glode M, Snijders A; Antigen presenting cell activation in sipuleucel-T and long-term immune responses in prostate cancer trial. ASCO Ed Book, 2009. Lam ET, Glode LM; Management of locally advanced prostate cancer. Handbook of Urology, Second Edition, Chapter 21.9, 2011. Sweeney CJ, Canellos GP, Bunn HF, Glode LM, et.al.: Clinics Review Articles Hematology/Oncology Clinics of North America – Prostate Cancer. Vol. 27, Num.6, Dec. 2013. Abstracts 1. Glodé LM, Scher I, and Rosenstreich DL: Endotoxin unresponsiveness in C3H/HeJ mice. Fed Proc 34:951, 1975. 2. Glodé LM: Genetic control of endotoxin responses in mice. Fed Proc 35:824, 1976. 3. Ryan J, Glodé LM, and Nathan C: LPS induced glucose utilization in C3H/HeN and C3H/HeJ macrophages. Fed. Proc. 36:1263, 1977. 4. Glodé LM, Israel M, Pegg WJ, and Wilkinson PM: Hepatobiliary metabolism and excretion of adriamycin in man. Proc Brit Pharmacol Soc, p. 35, 1977. 14 Glodé 10/14 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. Garnick MB, Israel M, Ensminger WD, and Glodé LM: Pharmocological advantages of adriamycin via intrahepatic arterial infusion. Proc Amer Assoc Cancer Res 19:400, 1978. Glodé LM, Pitman SW, and Frei E III: Phase I study of high dose aminopterin with citrovorum factor rescue. Proc AACR and ASCO 19:634, 1978. Corkery JC, Glodé LM, Whipple C, McIntosh EN, Holtrop HR, and Salhanick HA: Inhibition of peripheral aromatization by aminoglutethimide. Proc Amer Assoc. Cancer Res 20:233, 1979. Glodé LM, Hartmann DW, and Robinson WA: The acute and cumulative marrow toxicity of chemotherapy in small cell carcinoma of the lung with and without bone marrow support. Proc Amer Soc Clin Onc 21:448, 1980. Glodé LM, Epstein AL, and Smith CG: Reduction in the amount of cystathionase contained in human leukemic cell lines as determined by quantitative radioimmunoelectrophoresis using a monoclonal hybridoma antibody. Proc Amer Assoc Cancer Res 21:11, 1980. Glodé LM, Epstein AL, Smith C, and Robinson WA: Cystathionase: Measurement by radioimmunoelectrophoretic assay using hybridoma antibody and its potential use as a marker of leukocyte differentiation. Clinical Res 28:525A, 1980. Robinson JI, Gould SF, Glodé LM, and Robinson WA: Protection from cyclosphosphamide induced testicular damage by an analogue of gonadotropin releasing hormone. Proc of Am Fed Clin Res meeting, Feb. 198l. Harvey HA, Lipton A, Santen RJ, Escher GC, Hardy MA, Glodé LM, Segaloff A, Landau RL, Schneir H, and Max DT: Phase II study of a gonadotropin-releasing hormone analogue (Leuprolide) in postmenopausal advanced breast cancer patients. Proc ASCO 22:444, 1981. Schneir HE, Landau RL, Max D, Harvey HA, Lipton A, Santen RJ, Escher GC, Hardy MA, Glodé LM, and Segaloff A: The endocrine effects of chronic treatment with a gonadotropin releasing hormone (GnRH) analogue. Endocrine Society, 1981. Warner B, Santen R, Demers L, Max D, Lohmar P, Smith J, Muss H, Resnick M, Glodé LM, Wettlaufer J, Eisenberger M, and Block N: Effects of [D-Leu-6-Des-Gly-NH2 10, Pro-ethylamide9]-GnRH (Leuprolide) on steroidogenesis when used to treat prostatic carcinoma. Am Soc of Andrology 3(1):14, 1982. Dantas ME, Robinson WA, Thomas MR, Koeppler H, and Glodé LM: Autologous marrow infusion in blastic crisis of chronic myeloid leukemia. Blood 58 (5)(Suppl. 1):172a, 1981. Link D, Glodé LM, Drebing C: Cystathionase--A new marker of leukemic differentiation. Blood 58(5)(Suppl. 1):145a, 1981. Glodé LM, Gould SF, Nett T, and Powell D: A rat model for MOPP induced male infertility. Proc of Am Assoc Cancer Res 23:222, 1982. Glodé LM: Leuprolide therapy of advanced prostatic cancer. Proc of Am Soc Clin Onc 1:110, 1982. Rifkin JI, Horwitz LD, Glodé LM: Hypothermic modulation of cutaneous and testicular vascular resistance. Am Fed Clin Res (Western), February, 1983. Smith H, Geyer M, Stears J, Kindt G, Glodé L.M: Intra-carotid BCNU in the treatment of malignant brain tumors. A phase I trial. Am Fed Clin Res (Western), February, 1983. Thomas MR, Robinson WA, Dantas M, Koeppler H, Glodé LM, Drebing C: Autologous bone marrow transplantation in chronic mylogenous leukemia (CML) in blast crisis. Am Fed Clin Res (Western), February, 1983. 15 Glodé 10/14 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. Thomas MR, Robinson WA, Glodé LM, Koeppler H, Dantas M, Morton N: Treatment of advanced malignant melanoma with high dose BCNU and melphalan and autologous bone marrow transplantation - preliminary results phase I. Am Fed Clin Res (Western), February, 1983. Thomas MR, Robinson WA, Mughal T, Morton N, Glodé LM, and Garfield D: Autologous bone marrow transplantation and high dose chemotherapy in advanced malignant melanoma phase 1 study. Proc Am Soc Clin Onc 2:243, 1983. Klein CE, Glodé LM, and Helson C: Cystathionase expression in human neuroblastoma (N) cell lines. Proc Am Assoc Cancer Res 24:40, 1983. Chitambar CR, Glodé LM, Robinson WA, and Lehman J: Low dose 5-azacytidine therapy in leukemia. Proc Am Assoc Cancer Res 24:299, 1983. Glodé LM, Robinson WA, Hartmann DH, and Morton N: Pharmacokinetics of high dose combination therapy using a CFU-c bioassay. Proc Am Soc Clin Onc 2:24, 1983. Geier JM, Smith H, Braun T, Gross C, Kindt G, and Glodé LM: Extracerebral toxicity of continuous intracarotid FUDR via implanted infusaid pump in brain tumor patients. Surg Forum, 1983. Glodé LM, Max D, and the Takeda-Abbott Prostatic Cancer Study Group: Leu prolide (Dleu6-Des Gly10-Pro9-NH et-LHRH) in the therapy of advanced prostatic carcinoma. 13th International Congress of Chemotherapy 242:49-53, 1983. Shannon JM and Glodé LM: Demonstration of direct effects of [d-leu6, pro9- NEt]LHRH (Leuprolide) in the rat testis in vivo. Presented at 8th NICHd Inter national Workshop on the Testis, October 14-17, 1983, Bethesda, Maryland. Shannon JM, and Glodé LM: Cultivation of sertoli cells on floating collagen gels: An improved method for studying cell-cell interactions in vitro. Presented at 8th NICHD International Workshop on the Testis, October 14-17, 1983, Bethesda, Maryland. Mughal TI, Glodé LM, Braun TJ, Geyer M, and Kindt G: Phase I study of intra-arterial Bis-chloroethyl nitrosourea and 2'-deoxy-5-fluorouridine in malignant astrocytomas. Presented at the 75th Annual Meeting of the American Association for Cancer Research, May 10, 1984. Manni A, Santen RJ, Boucher A, Lipton A, Harvey H, White D, Simmonds M, Rohner T, Drago J, Wettlaufer J, and Glodé LM: Aminoglutethemide and chemotherapy with and without transient androgen administration in the treatment of advanced prostate cancer. Proc Amer Soc Clin Onc 3:152, 1984. Glodé LM, and Smith CG: Evaluation of cysteine analogues as cytotoxins in cysteine auxotrophic/prototrophic cell lines. Proc Amer Assoc Cancer Res 1984. Mughal TI, Robinson WA, Thomas MR and Glodé LM: Malignant melanoma and BCNU. Clin Onc 10:185, 1984. Glodé LM: Long-term safety of the GnRH analogue, Leuprolide (Lupron, Leu) vs. Diethylstilbesterol (DES) in metastatic prostate cancer--An update. 14th International Congress of Chemotherapy, 1985. Glodé LM: Mode of action and therapeutic potential of the LHRH agonist, Leuprolide. 14th International Congress of Chemotherapy, 1985. Glodé LM: Long-term toxicity of the GnRH analogue, Leuprolide (Lupron, LEU) vs. Diethylstilbesterol (DES) in metastatic prostate cancer - An up date: Part II. Amer Soc Clin Onc, 1985. Glodé LM, Shannon JM, Nett TM, and Carl VS: Differences in the effects of a GnRH agonist on human and rodent spermatogenesis. Am Fed Clin Res, 1985. 16 Glodé 10/14 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. Manni A, Santen RJ, Boucher A, Lipton A, Harvey H, White D, Simmonds M, Gordon R, Rohner T, Drago J, Wettlaufer J, and Glodé LM: Potentiation of the effect of chemotherapy in stage D2 prostate cancer by transient androgen administration. Proc ASCO, 1985. Maxwell IH, Maxwell F, Glodé LM: Regulated expression of transfected toxin genes - A potential new therapeutic strategy. Proc. AACR, 1986. Inter Cong of Chemotherapy, Kyoto, Japan, 1985. Manni A, Santen R, Boucher A, Lipton A, Harvey H, White D, Simmonds M, Gordon R, Rohner T, Drago J, Wettlaufer J, and Glodé LM: Androgen priming and response to chemotherapy in advanced prostate cancer. Presented: Pennsylvania Oncologic Society Annual Meeting, September 12-13, 1986, Hershey, Pennsylvania. Manni A, Santen R, Boucher A, Lipton A, Harvey H, White D, Simmonds M, Gordon R, Rohner T, Drago J, Wettlaufer J, and Glodé LM: Androgen priming and chemotherapy in advanced prostate cancer. Presented: 1st International Symposium on Advances in Urologic Oncology, Sanremo, Italy January 22-24, 1987. Manni A, Santen R, Boucher A, Lipton A, Harvey H, White D, Simmonds M, Gordon R, Rohner T, Drago J, Wettlaufer J, and Glodé LM: Androgen priming and chemotherapy in advanced prostate cancer. Proc ASCO, 1987. Klein C, Glodé LM: Brain Metastases in Malignant melanoma: Risk factors, routines of spread and outcome. Proc ASCO, 1987. Manni A, Santen R, Boucher A, Lipton A, Harvey H, White D, Simmonds M, Gordon R, Rohner T, Drago J, Wettlaufer J, Glodé LM: Androgen priming and chemotherapy in advanced prostate cancer. Presented: Intl. Symposium on Hormonal Therapy of Prostatic Disease, Milano, Italy, 1987. Glodé LM, Maxwell IH, Maxwell F, Sitarik M, Kallio A, Ulmanen I: Regulated Expression of a Transfected Diphtheria Toxin A-Chain Gene as a Novel Mechanism for Eliminating Specific Target Cell Populations. Presented: XVII Linderstrom-Lang Conference on Receptor Effector Mechanisms and Gene Regulation, Geilo, Norway, April 26-30, 1987. Manni A, Santen RJ, Boucher AE, Lipton A, Harvey HA, Simmonds MA, White-Hershey D, Gordon RA, Rohner TJ, Drago J, Wettlaufer J, Glodé LM: Androgen priming and chemotherapy in the treatment of advanced prostate cancer. Proc of Intl Symp on Hormon TX of Prost Dis, Medic (UK)Inc. (In press) 1987. Glodé LM, Maxwell IH, Maxwell F, Sitarik M, Kallio A, Ulmanen I: Regulated Expression of a Transfected Diphtheria Toxin A-Chain Gene as a Novel Mechanism for Eliminating Specific Target Cell Populations. Presented: European Assoc Cancer Research, Helsinki, Finland, June 1987. Maxwell IH, Glodé LM, Maxwell F: HTLV-regulated expression of a transfected diptheria toxin gene. Presented at Human retroviruses, cancer and AIDS meeting, April 1-6, 1987. Manni A, Santen R, Boucher A, Lipton A, Harvey H, Simmonds M, White-Hershey D, Bartholomew M, Caplan R, Gordon R, Rohner T, Drago J, Wettlaufer J, Glodé LM: Novel approaches to the treatment of advanced prostate cancer. 1988. Manni A, Bartholomew M, Caplan R, Boucher A, Santen R, Lipton A, Harvey H, Simmonds M, White-Hershey D, Gordon R, Rohner T, Drago J, Wettlaufer J, Glodé LM: Androgen priming and chemotherapy in advanced prostate cancer. Evaluation of determinants of clinical outcome. 1988. 17 Glodé 10/14 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. Glodé LM, Maxwell IH, Maxwell F, Sitarik M, Kallio A, Ulmanen I: Regulated expression of a transfected diptheria toxin gene as a novel mechanism for killing tumor cells. J Cellular Biochem Suppl 12B, 1988. Maxwell IH, Glodé LM, Maxwell F: Diphtheria toxin A-chain expression directed to Blymphoid cells. J Cellular Biochem Suppl 12B, 1988. Manni A, Bartholomew M, Caplan R, Boucher A, Santen R, Lipton A, Harvey H, Simmonds M, White D, Gordon R, Rohner T, Drago J, Wettlaufer J, and Glodé LM: Determinants of biologic behavior in advanced prostate cancer. Proc ASCO 1988. Fisher KS, Maxwell IH, Glodé LM: Expression of mutant diphtheria toxin A-chain expression plasmids in eukaryotic cells. Proc AACR 30:627, 1989. Glodé LM, Su L-J, Maxwell F, Maxwell IH, and Nilson J: Toward toxin gene therapy of cancer. Use of a and b HCG promoters to regulate expression of diphtheria toxin A-chain (DT-A) in model target cells. Proc AACR 30:627, 1989. Su L-J, Maxwell IH, Harrison GS, Glodé LM: Assay of retrovirus infectivity by transduction of luciferase. Proc AACR 32:299, 1991. Glodé LM, The Leuprolide Study Group: Long term evaluation of leuprolide versus DES treatment for prostate cancer. Proc ASCO 1991. Yu NY, Kaleta-Michaels SJ, Singh SS, Luck EE, and Brown DM, Menlo Park, CA; Daneshi-Gari F, and Glodé LM: Intraprostatic Therapeutic Implant Provides Sustained Drug Release in Rate Prostate. August, 1992. Lidor YJ, Maxwell IH, Feldman I, Brand E, Glodé LM: Generation of a New Therapeutic Retroviral Vector, pLNX-TH47R, for Toxin Gene Therapy in Ovarian Cancer. November 1992. Walsh P, Duke RC, Schleicher M, Dorner A, and Glodé LM: Assessment of the cellular immune response to a macrophage colony stimulating factor producing melanoma cell line. October 1993. DeAntoni EP, Dyer BA, Glodé LM, and Kogel C: Knowledge, attitudes and health behaviors among participants in a prostate cancer screening program. 1993. Glodé LM, Crawford ED, Majeski S, Schmidt R, Cook S and Murphy J: Sinusoidal floxuridine (FUDR) infusions for treatment of advanced hormone refractory prostate cancer. PROC ASCO, 1994. Dumont FD, Su LJ and Glodé LM: Intact cell luciferase assay as a rapid tumor sensitivity test. PROC AACR 35:1221, 1994. Walsh P, Dorner A and Glodé LM: Gene therapy for melanoma using M-CSF and the B16F10 cell line. Gene Therapy, 1994. Klein CE, Prochazka A, Spitzer AL, Gordon B, Glodé LM: Spousal report of quality of life in treatment for localized prostate cancer. ASCO Annual Meeting, May 18-21, 1996. Lee WE, Gorman C, Roche L, Michaud B, Su LJ, Tomczak JA, Glodé LM. In vivo delivery of foreign genes by liposomes into an ovarian cancer animal model. ASCO Annual Meeting, May 18-21, 1996. May DJ, Shroyer, K, Glodé LM: Detection of Telomerase activity in immortal prostate cancer cell lines in peripheral blood samples. American Urological Association, Inc, September 7-11, 1996. Shroyer KR, May DJ, Cutler W, Markham N and Glodé LM: Prostate cancer screening by telomerase assay of seminal fluid. ASCO Annual Meeting, May 17-21, 1997. Bacha P, Fowlie A, Grimaldo D, Hillier J, Olsen E, Martin A, Kim Y, Duvic M, Frankel A, Vonderheid E, Bowen G, Jegasothy B, Wood, G, Gordon M, Pinter-Brown L, Fivenson D, Heald P, Oseroff A, Kuzel T, Foss F, Glodé M, Stewart S, Molina A, Knobler B: Antibody 18 Glodé 10/14 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. and pharmacokinetic analysis from a pivotal trial of DAB389 IL-2 for the treatment of cutaneous T-cell lymphoma (CTCL). Presented at the American Society of Hematology annual meeting, December 4-9, 1997. Kuzel T, Olsen E, Martin A, Kim Y, Davis M, Frankel A, Vonderheid E, Bowen G, Jegasothy B, Wood G, Gordon M, Pinter-Brown L, Fivenson D, Heald P, Oseroff A, Foss F, Glodé M, Stewart S, Molina A, Knobler B, Nichols J: Phase III trials of two dose levels of a diptheria toxin (DT) fusion protein (DAB389 IL-2) for the treatment of mycosis fungoides (MF/SS). Presented at American Society of Hematology annual meeting, December 4-9, 1997. Garnick MB, Wierman M, Kuca B, Joyce R, Martin K, O’Hagen P, Glodé LM, Gefter M: The “acute on chronic” phenomenon - a manifestation of inadequate gonadotropin suppression - is common with currently available LHRH superagonists. Presented at the American Urologic Association, May 1-6, 1999. Menon M, Glodé LM, Martin K, McLeod D, Cohen S, Steadman B, Molineaux C, Gefter ML, Kuca B and Garnick MB: Abarelix (PPI-149), a novel and potent GnRH antagonist, induces a rapid and profound reduction in testosterone and PSA in advanced prostate cancer patients (PrCa). Presented at the American Urologic Association, May 1-6, 1999. Nett TM, Allen MC, Wieczorek M, Glodé LM: A gonadotropin-releasing hormone agonist (GnRH-A) linked to pokeweed antiviral protein (PAP) decreases the ability of the pituitary gland to secrete LH. Society for the Study of Reproduction, August 1999 (Abstract #430). Reznikov LL, Trollinger DB, Miller HL, Emmick JA, Johannes WU, Kim S-H, van Bokhoven A, Tryon VV, Glodé LM, Miller GJ and Dinarello CA: Cytokine expression in normal and malignant prostate epithelium. Focus on IL-18 system. European Cytokine Network, volume 11, 2000 (Abstract #26027). Duncan MW, Fung K, Zirrolli J, Basile F, Glodé LM and Miller JY: Qualitative and quantative proteomics applied to the identification of cancer biomarkers in biological fluids. Submitted to the IMAT PI Meeting, sponsored by the National Cancer Institute, June 2001. Abouelfadel Z, Miller GJ, Glodé LM, Akduman B, Hooda M, Donohue RE, Nedrow A, Crawford ED: High Gleason Sums and Lower PSA in a Single Institution over the Past Decade. Proceedings of American Society of Clinical Oncology 20:153b (Abstract #756), 2001. Brian D. Kavanagh; David A. Raben; Marcus Chen; Robert Quaife; Chris Kelsey; L Michael Glodé; Andrew Kraft; Tracey Schefter; E David Crawford. Indium-111 Capromab pendetide staging for rising PSA after prostatectomy: Implications for salvage radiotherapy. Submitted to AUA. Bakemeier RF, Glodé LM, Bondy J, Bair C, Montour M, Dempsey B and Winn RA: Further evolution of the University of Colorado Cancer Center student cancer research fellowship program, 1998-2003. Presented at the annual meeting of the American Association of Continuing Education, October 2003. Tyagi A, Agarwal C, Glodé LM, and Agarwal R: Silibinin efficacy in human bladder transitional cell carcinoma: modulation of cell cycle and apoptosis cascades. AACR, 2004. Singh R P, Sharma G, Dhanalakshmi S, Glodé LM, and Agarwal R: Silibinin inhibits human bladder transitional-cell papilloma RT4 tumor xenograft growth in athymic nude mice. AACR, 2004. Agarwal R, Su L-J, Flaig T, Harrison GS, Gustafson D, and Glodé LM: A phase I clinical study of silibinin in patients with prostate cancer. Prostate Cancer Foundation, October 2004. 19 Glodé 10/14 83. 84. 85. 86. 87. 88. 89. 90. 91. 92. 93. 94. Werahera PN, Hedlund T, Glodé LM, Easterday K, Crawford ED, Lucia S, Crighton F, Stewart JS, Robischon M, Miller GJ. Proliferative tumor doubling times of prostatic carcinoma measured by in vivo bromodeoxyuridine (BrdU) labeling and flow cytometry analysis. Submitted AUA, 2005. Flaig T, Barqawi AB, Kane M, Miller G, Crawford E D , and Glodé LM: A Phase II trial of dexamethasone, 1,25-dihydroxyvitamin D and carboplatin in patients with hormone refractory prostate cancer. Submitted ASCO Prostate Symposium, 2005. Flaig TW, Agarwal R, Su L, harrison GS, Gustafson D, and Glodé LM: A Phase I study of silibinin in hormone refractory prostate cancer. Submitted ASCO, 2005. Hussain M, Petrylak D, Dunn R, Vaishampayan U, Lara PN, Chatta G, Nanus D, Glodé LM, Trump D, Chen H, Smith DC. Trastuzumab (T), Paclitaxel (P), Carboplatin (C) and Gemcitabine (G) in the Treatment of Advanced HER2-positive Urothelial Cancer: Results of a Multi-Center PhaseII NCI Trial. ASCO, 2005. Flaig TW, Su L, Harrison G, Agarwal R, and Glodé LM: Silibinin synergizes with mitoxantrone to decrease cell viability in prostate cancer cells. ASCO Prostate Symposium, 2006. Kantoff PW, Glodé LM, Tannenbaum SI, Bilhartz DL, Pittman WG, Schuetz TJ: Randomized, double-blind, vector-controlled study of targeted immunotherapy in patients (pts) with hormone-refractory prostate cancer (HRPC). ASCO Prostate Symposium, 2006. Attia, S, Eickhoff J, Wilding G, McNeel D, Blank J, Rezazadeh H, Jumonville A, Eastmand M, Shevrin D, Glodé LM, Liu G: Randomized phase II trial of doectaxel, with or without doxercalciferol, in androgen-independent prostate cancer. ASCO, June 2007. Flaig, T, Glodé LM, Gustafson D, VanBokhoven A, Tao Y, Wilson S, Su L-J, Li Y, Harrison G, Agarwal R, Crawford ED, Lucia S, Pollak M: A pilot study of oral silybinphytosome followed by prostatectomy in patients with localized prostate cancer, AACR April 2009. Thomas W. Flaig, L. Michael Glode, Daniel Gustafson, Adrie VanBokhoven, Yuzhen Tao, Shandra Wilson, Lih-Jen Su, Yuan Li, Gail Harrison, Rajesh Agarwal, E. David Crawford, Scott Lucia, Michael Pollak. University of Colorado Denver, Aurora, CO, Colorado State University, Fort Collins, CO, McGill University, Montreal, QC, Canada: A pilot study of oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. ASCO 2009. P.W. Kantoff, T.J. Schuetz, B. Blumenstein, L.M. Glode, D.L. Billhartz, J. Gulley, J. Schlom, R. Laus, and W. Godfrey: Overall survival (OS) analysis of a prospective randomized Phase II controlled study of a poxviral-based PSA targeted immunotherapy, in metastatic castration-resistant prostate cancer (mCRPC). ASCO 2009. W.R. Godfrey, B.A. Blumenstein, T.J. Schuetz, L.M. Glode, D.L. Billhartz, J.L. Gulley, P. Arlen, J. Schlom, R. Laus, and P.W. Kantoff.; Further analysis of a Phase II randomized controlled trial (RCT) of a poxviral-based PSA targeted immunotherapy in metastatic castration-resistant prostate cancer (mCRPC). ECCO 2009. AE Frankel, A Thorburn, ML Glode: Compositions and Methods for Treating Bladder Cancer: The present invention provides methods and compositions for treating bladder cancer. In particular, the present invention provides a fusion protein comprising a toxin moiety that is linked to an epithelial growth factor (EGF) moiety. ASCO 2012. INVITED LECTURES (representative) 20 Glodé 10/14 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. “Prostate Cancer -- Screening, Surgery, Radiation or Observational Therapy: Outcomes and Costs”. Department of Medicine Grand Rounds, University of Colorado Health Sciences Center, October 1997, Denver CO. “Cell Biology for Clinicians”. American Association for Cancer Research Course Molecular Biology for Clinical Oncologists. October 22-26, 1997, Beijing, China. “Cancer Information on the World Wide Web”. American Society of Clinical Oncology Annual Fall Meeting. November 7-9, 1997, Orlando FL. “Prostate Cancer Treatment After Hormone Failure”. The Institute for Research and Education Health System Minnesota Fall Oncology Lecture. November 13, 1997, Minneapolis MN. “Oncology on the Internet“. Grand Rounds, McFarland Hospital, November 14, 1997, Minneapolis MN. “Potpourri of Tumor Cases”. Penrose Cancer Conference, Colorado Springs CO, September 17-18, 1999. “Internet Oncology Training” 11th Pittsburgh Cancer Conference, Pittsburgh PA, March 22, 2001. “Prostatic Carcinoma”. Medicine Grand Rounds, University of Colorado Health Sciences Center, April 2001, Denver CO. “Treatment Options for Advanced Prostate Cancer”. Recent Advances in Prostate Cancer conference, May 18, 2001, Boston MA. “Prevention of Prostate Cancer - Current Data and Experimental Approaches”. First International Prostate Cancer Congress, June 27-30, 2001, San Juan, Puerto Rico “How to Get Information from the Internet”. 47th Annual Family Practice Review of the University of Colorado School of Medicine, June 24-30, 2001, Estes Park CO. “Gene Therapy”. University of Colorado School of Medicine course CLSC7500, July 16, 2001, Denver CO. “Update on Bladder Cancer”. Exempla/Lutheran Bladder Cancer Support Group, July 24, 2001, Denver CO “Prostate Cancer”. Cancer Center Summer Students, August 1, 2001, Denver CO. Future Directions in Urology Meeting, Aug. 8-10, 2013. International Prostate Cancer Update Meeting, Feb. 19-21, 2014. 21