GASTROINTESTINAL IMMUNOPHYSIOLOGY
Graduate Institute of Physiology
National Taiwan University College of Medicine
課程編號
全/半年
授課教師
上課時間
備註
441 M2600
學分數
半年
必/選修
余佳慧
開課系所
星期三 34
上課地點
修課人數上限 25 人，初選外系人數上限
籍。
Yu LCH
2
選修
生理所
基醫 1003
10 人。英文授課，英文書
This course is intended for further in-depth study of the gastrointestinal
physiology and immunology. Undergraduate students over forth year, and graduate
students in medicine-and biology-related studies are encouraged to take the course. The
course is offered as two credits per school term. The course content includes lectures and
discussions of scientific papers in the field of gastrointestinal physiology. Students will
be graded by participation in class (10 %), an essay (30 %), and presentations (60 %).
The text of the essay should be double-spaced and with a minimum of 10 pages not
including figures, tables, references or appendix. Please design two short essay questions
with answers based on your review in the appendix. Additional assignments for PhD
students only, please include two to three questions about what is still unknown in the
field.
Functions of the gastrointestinal tract include motility, digestion, absorption,
secretion and barrier. The GI tract plays dual roles, one serving as the first line for
nutrient uptake and the other as a defense system against microbial pathogens. The
gastrointestinal tract is the largest reservoir of commensal bacteria in the human body,
providing nutrient and space for the survival of microbes while concurrently operating
mucosal barriers to confine and restrict the microbial population. The turnover rate of
intestinal epithelial cells along the crypt/villus axis that involves processes of
proliferation, differentiation, apoptosis and shedding is crucial for maintenance of gut
homeostasis. Recent scientific studies suggest dynamic interaction among enteric nervous
system, immune system and the gastrointestinal mucosa. The lymphoid tissues in the
gastrointestinal tract contain the largest number of immune cells in the body, termed gutassociated lymphoid tissue (GALT). The gastrointestinal immunity protects against
invasion of potential pathogens, and provides oral tolerance to food proteins without
developing an adverse immune response to unharmful dietary particles. The balance
between immunity and tolerance in the gut plays a crucial role in the pathogenesis of
various gastrointestinal diseases.
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GASTROINTESTINAL IMMUNOPHYSIOLOGY
March- 2015
Graduate Institute of Physiology
National Taiwan University, College of Medicine
Yu LCH
Introduction
1. Gastrointestinal histology and physiology
Digestion and absorption:
2. Brush border enzymes and Nutrient transporters: sodium-dependent glucose
transporter and di/tripeptide transporter PEPT1
Secretion:
3. Anion secretion: chloride and bicarbonate ions
Motility and neural regulation, brain-gut axis:
4. Bowel distension, intestinal transit, and pain perception
Barrier function:
5. Chemical barrier function: defensins and cathelicidin
6. Physical barrier function: tight junctions and epithelial permeability
Crypt-villus axis, apoptosis/proliferation, and carcinogenesis
7. Pattern recognition receptor and carcinogenesis
8. Inflammasome-driven carcinogensis
Commensals and probiotics
9. Gut commensal bacteria and enteric dysbiosis
10. Symbionts/Probiotics and gut immunity
Intestinal innate immunity: neutrophils and macrophages
11. Intestinal macrophages: activation vs. anergy
12. Resident versus infiltrating macrophages
Intestinal adaptive immunity and Gut-associated lymphoid tissue (GALT)
13. Peyer’s patches and isolated lymphoid follicles
14. Dendritic cells
Oral tolerance
15. Balance between Treg cells and Th17 cells
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