February 15, 2016 Jack D. Keene, PhD Department of Molecular Genetics & Microbiology 414 Jones Building, Research Drive Box 3020 Duke University Medical Center Durham, NC 27710 Sayan Mukherjee, PhD Assistant Professor Institute for Genome Sciences & Policy Institute of Statistics and Decision Sciences Dear Dr. Keene, I am writing to voice my enthusiastic support of your NSF FIBR grant application on global mechanisms of post-transcriptional gene regulation. I believe that your proposed use of statistical and machine learning methods to analyze transcript variants and interaction data will provide new insights into the mechanisms of gene expression. As we have discussed, my role in the project will involve consulting on issues pertaining to data classification, feature selection, and statistical/machine learning issues, in particular as related to microarray data sets. Our laboratory has extensive experience in the analysis of genomic data, and we are happy to share our knowledge and resources with you in this cooperative endeavor. I am strongly enthusiastic about your proposed project and look forward to working with you. Sincerely, Sayan Mukherjee, PhD Assistant Professor Department of Computer Science Duke University CIEMAS 101 Science Drive Box 3382 Durham, NC 27708 T F 919-668-4747 919-668-0795 www.genome.duke.edu