PRESS RELEASE
November 28, 2011
Leica Microsystems Launches the First Fully Automated One-step Dual
Chromogen IHC Detection System for Use With Antibody Cocktails
Leica Microsystems announced today the availability of Leica ChromoPlex™ 1 Dual Detection for
BOND, the first fully automated one-step detection system allowing the co-visualization of mouse and
rabbit antibodies on a single slide. Same day diagnosis is now easier to achieve when compared with
the two-step sequential or semi-automated processes currently available on competitive IHC advanced
stainers. Developed for use with commercial and self-validated cocktails, ChromoPlex delivers the
intense staining and clear background that BOND users currently enjoy from Leica’s Compact Polymer
technology.
“When tissue is limited and diagnostic
decisions are needed, the most effective use
of tissue sections becomes imperative”
comments Konstantin Fiedler, Vice President
of
Advanced
Microsystems.
Staining
“The
for
turnaround
Leica
times
achievable with our new ChromoPlex range
open the door to faster patient management,
while maintaining the diagnostic confidence
pathologists demand to make the right
decisions.
Laboratories
can
choose
antibodies from different sources, ensuring
the most effective combinations of antibodies
to aid diagnosis can always be used”.
“The
dual
staining
obtained
using
the
ChromoPlex 1 detection system is attractive,
crisp and consistent; ideal when assessing
User Validated Prostate Marker Cocktail - P504S (Red) and HMW
CK (DAB). Digital image captured using the Leica SCN400 Slide
Scanner.
The printable image can be ordered from:
corporate.communications@leica-microsystems.com
Dr. Kirstin Henze · T +49 (0)6441 / 29 - 2550 · F +49 (0)6441 / 29 - 2527 · corporate.communications@leica-microsystems.com
Leica Microsystems GmbH · Ernst-Leitz-Straße 17–37 · D-35578 Wetzlar · www.leica-microsystems.com
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PRESS RELEASE
challenging prostatic biopsies,” states Dr Geoffrey Hulman MD FRCPath, Consultant Histopathologist at
Nottingham University Hospitals NHS Trust, where the detection technology was evaluated in
cooperation with the Nottingham Health Science Biobank. Dr Claire Hawkes PhD, CSci comments that
“historically, we encountered problems with dual staining and efforts to stain up commercial cocktails
have been largely unsuccessful. The ChromoPlex 1 detection system, however, enables quick easy
staining of both commercial and in-house home-brew cocktails, with excellent results.”
ChromoPlex 1 Dual Detection is a biotin-free, polymeric horseradish peroxidase (HRP)-linker and
polymeric alkaline phosphatase (AP)-linker antibody conjugate system for the detection of tissue-bound
mouse and rabbit IgG primary antibodies. The small multifunctional linkers enhance tissue penetration,
producing high sensitivity. The excellent contrast between the Fast Red and DAB chromogens allows
for easy antigen differentiation.
ChromoPlex 1 Dual Detection for BOND is intended for staining sections of formalin fixed, paraffinembedded tissue for use on Leica BOND-MAX and BOND-III automated IHC staining systems. It can be
used simultaneously with both Novocastra BOND Polymer Refine and Polymer Refine Red Detection,
allowing unparalleled flexibility in staining protocols and workflow efficiency.
ChromoPlex 1 Dual Detection for BOND will be available for sale from December 1, 2011 in the
United States of America, Canada, and the European Union.
_______________
Leica Microsystems is a world leader in microscopes and scientific instruments. Founded as a family
business in the nineteenth century, the company’s history was marked by unparalleled innovation on its
way to becoming a global enterprise.
Its historically close cooperation with the scientific community is the key to Leica Microsystems’ tradition
of innovation, which draws on users’ ideas and creates solutions tailored to their requirements. At the
global level, Leica Microsystems is organized in four divisions, all of which are among the leaders in
their respective fields: the Life Science Division, Industry Division, Biosystems Division and Medical
Division.
Leica Microsystems’ Biosystems Division, also known as Leica Biosystems, offers histopathology
laboratories the most extensive product range with appropriate products for each work step in histology
and for a high level of productivity in the working processes of the entire laboratory.
The company is represented in over 100 countries with 12 manufacturing facilities in 7 countries, sales
and service organizations in 19 countries and an international network of dealers. The company is
headquartered in Wetzlar, Germany.
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