Cristina Airoldi –Publication list
January 2015
Cristina Airoldi
Bergamo, February 13, 1979
via Antonio Gramsci 5/c, 23879, Verderio, LC, ITALY
cell. +39 3287184950
tel. +39 02 6448 3422; 3303
cristina.airoldi@unimib.it
Publications:
1. Peri F., Airoldi C., Colombo S., Martegani E., Van Neuren A. S., Stein M., Marinzi C., Nicotra F.,
Design, Synthesis and Biological Evaluation of Sugar-Derived Ras Inhibitors, ChemBioChem, 2005, 6,
1839-1848.
2. Peri F., Airoldi C., Colombo S., Mari S., Jimenez-Barbero J., Martegani M., Nicotra F., Sugar-derived
Ras inhibitors: Group Epitope Mapping by NMR Spectroscopy and Biological Evaluation, Eur. J. Org.
Chem., 2006, 16, 3707-3720.
3. Nicotra F., Airoldi C., Cardona F. Synthesis of C- and S-Glycosides, in Comprehensive Glycoscience,
Kamerling J. P. Ed., Elsevier, 2007, 647-683.
4. Cipolla L., Reis Fernandes M., Gregori M., Airoldi C. and. Nicotra F., Synthesis and biological
evaluation of a small library of nojirimycin-derived bicyclic iminosugars, Carbohydr. Res., 2007, 342,
12-13, 1813-1830.
5. Airoldi C., Palmioli A., D’Urzo A., Colombo S., Vanoni M., Martegani E., and Peri F., Glucose-derived
Ras pathway inhibitors: evidence of Ras-ligand binding and Ras-GEF (Cdc25) interaction inhibition,
ChemBioChem, 2007, 8, 1376-1379.
6. Nicotra F., La Ferla B., Airoldi C. Aminated Sugars, Synthesis and Biological Activity, In “Amino
Group Chemistry, Ricci A. Ed., Wiley-VCH, 2008, 257-304.
7. Araujo A. C., Nicotra F., Airoldi C., Costa B., Giagnoni G., Fumagalli P., Cipolla L., Synthesis and
biological evaluation of novel rigid 1,4-benzodiazepine-2,5-dione chimeric scaffolds, Eur. J. Org. Chem.,
2008, 635–639.
8. Cipolla L., Peri F., Airoldi C., Glycoconjugates in cancer therapy. Anti Canc Agents Med Chem, 2008,
8, 1, 92-121.
9. Cipolla L., Airoldi C., Galliani P., Polissi A., Nicotra F., Re LPS biogenetic pathway: Enzyme
characterisation and Synthetic efforts towards inhibitors, Curr. Org. Chem., 2008, 12, 7, 576-600.
10. Cipolla L., Araújo A. C., Airoldi C., Bini D., Pyrrolo[2,1-c][1,4]benzodiazepine as a scaffold for the
design and synthesis of anti-tumour drugs, Anti Canc Agents Med Chem, 2009, 9, 1, 1-31.
11. Cipolla L., Polissi A., Airoldi C., Galliani P., Sperandeo P. and Nicotra F., The Kdo biosynthetic
pathway toward OM biogenesis as target in antibacterial drug design and development, Curr. Drug
Discovery Technol., 2009, 6, 1, 19-33.
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Cristina Airoldi –Publication list
January 2015
12. Mueller C., Gomez-Zurita Frau M. A., Ballinari D., Colombo S., Bitto A., Martegani E., Airoldi C., van
Neuren A. S., Stein M., Weiser J., Battistini C. and Peri F., Design, Synthesis and Biological Evaluation
of Levoglucosenone-derived Ras Activation Inhibitors, ChemMedChem, 2009, 4, 524-528.
13. La Ferla B., Russo L., Airoldi C., Nicotra F., Solid-phase supported mimic of GDP-L-galactose,
Tetrahedron: Asymmetry, 2009, 20, 744–745.
14. Palmioli A. Sacco E., Airoldi C., Di Nicolantonio F., D'Urzo A., Shirasawa S., Sasazuki T., Di Domizio
A., De Gioia L., Martegani E., Bardelli A., Peri F., Vanoni M., Selective cytotoxicity of a byclic Ras
inhibitor in cancer cells expressing K-RasG13D, Biochem. Biophys. Res. Commun., 2009, 386, 593-597.
15. Nicotra F., Cipolla L., La Ferla B., Airoldi C., Zona C., Orsato A., Shaikh N., Russo L., Carbohydrate
scaffolds in chemical genetic studies, J. Biotechnol., 2009, 144, 3, 234-241.
16. Airoldi C., Merlo S., Nicotra F., Synthesis of 3-deoxy-D-threopentofuranose 5-phosphate a substrate of
arabinose 5-phosphate isomerase, J. Carbohydr. Chem., 2010, 29, 30–38.
17. Airoldi C., Sommaruga S., Merlo S., Sperandeo P., Cipolla L., Polissi A., Nicotra F., Targeting Bacterial
Membranes: NMR Spectroscopy Characterization of Substrate Recognition and Binding Requirements
of D-arabinose 5 Phosphate Isomerase, Chem. Eur. J., 2010, 16, 6, 1897-1902.
18. Colombo S., Palmioli A., Airoldi C., Tisi R., Fantinato S., Olivieri S., De Gioia L., Martegani E., Peri F.,
Structure-Activity Studies on Arylamides and Arysulfonamides Ras Inhibitors, Curr. cancer drug targets,
2010, 10, 2, 192-199.
19. Cipolla L., La Ferla B., Airoldi C., Zona C., Orsato A., Shaikh N., Russo L., Nicotra F., Carbohydrate
Mimetics and Scaffolds: Sweet Spots in Medicinal Chemistry, Future Med. Chem., 2010, 2, 4, 587-599.
20. Re F., Airoldi C., Zona C., Quattrocchi N., La Ferla B., Nicotra F., Masserini M., Beta Amyloid
Aggregation Inhibitors: Small Molecules as Candidate Drugs for Therapy of Alzheimer’s Disease, Curr.
Med. Chem., 2010, 17, 27, 2990-3006.
21. Airoldi C., Colombo L., Manzoni C., Sironi E., Natalello A., Doglia S. M., Forloni G., Tagliavini F., Del
Favero E., Cantù L., Nicotra F., Salmona M., Tetracycline prevents Aβ oligomer toxicity through an
atypical supramolecular interaction, Org. Biomol. Chem., 2011, 9, 463-472.
22. Cipolla L., Airoldi C., Bini D., Gregori M., Marcelo F., Jimenez Barbero J., Nicotra F., Fructose-based
proline analogues: exploring the prolyl trans/cis-amide rotamer population in model peptides, Eur. J.
Org. Chem. 2011, 128–136.
23. La Ferla B., Airoldi C., Zona C., Orsato A., Cardona F., Merlo S., Sironi E., D’Orazio G., Nicotra F.
Natural glycoconjugates with antitumor activity, Nat. Prod. Rep., 2011, 28, 630-648.
24. Cipolla L., Polissi A., Airoldi C., Gabrielli L., Merlo S., Nicotra F., New targets for antibacterial design:
Kdo biosynthesis and LPS machinery transport to the cell surface, Curr. Med. Chem., 2011, 18, 830-852.
25. Araújo A. C., P. Rauter A. Nicotra F., Airoldi C., Costa B., Cipolla L., Sugar-Based Enantiomeric and
Conformationally Constrained Pyrrolo[2,1-c][1,4]-Benzodiazepines as Potential GABAA Ligands, J.
Med. Chem., 2011, 54, 1266-1275.
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Cristina Airoldi –Publication list
January 2015
26. Airoldi C., Sommaruga S., Merlo S., Sperandeo P., Cipolla L., Polissi A., Nicotra F., Targeting
Bacterial Membranes: Identification of Pseudomonas aeruginosa D-Arabinose-5P Isomerase and
NMR Characterisation of its Substrate Recognition and Binding Properties, ChemBioChem, 2011,
12, 719–727.
27. Airoldi C., Sironi E., La Ferla B., Cardona F., Nicotra F., Aβ monomers, oligomers and fibrils: Structural
Features, Curr. Bioact. Compd., 2011, 7, 3, 198-213.
28. Airoldi C., Cardona F., Sironi E., Colombo L., Salmona M., Silva A., Nicotra F., La Ferla B., cis-glycofused benzopyran compounds as new amyloid-β peptide ligands, Chem. Commun., 2011, 47, 10266–
10268.
29. Manzoni C., Colombo L., Bigini B., Diana V., Cagnotto A., Messa M., Lupi M., Bonetto V., Pignataro
M., Airoldi C., Sironi E., Williams A., Salmona M., The molecular assembly of amyloid Aβ controls its
neurotoxicity and binding to cellular proteins, PlosOne, 2011, 6, 9, e24909.
30. Airoldi C.,* Zona C., Sironi E., Colombo L., Messa M., Aurilia D., Gregori M., Masserini M., Salmona
M., Nicotra F., La Ferla B.,* Curcumin derivatives as new ligands of Aβ peptides, J. Biotechnol., 2011,
156, 317-324.
31. Airoldi C.,* Giovannardi S., La Ferla B., Jiménez-Barbero J., Nicotra F.,* Saturation Transfer Difference
NMR experiments of membrane proteins in living cells under HR-MAS conditions: The interaction of
the SGLT1 cotransporter with its ligands, Chem. Eur. J., 2011, 17, 48, 13395-13399.
32. Chiaradonna F., Moresco R.M., Airoldi C., Gaglio D., Palorini R., Nicotra F., Messa C., Alberghina L.,
From cancer metabolism to new biomarkers and drug targets, Biotechnol. Adv., 2012, 30, 30-51.
33. Le Droumaguet B., Nicolas J., Brambilla D., Mura S., Maksimenko A., De Kimpe L., Salvati E., Zona
C., Airoldi C., Canovi M., Gobbi M., Noiray M., La Ferla B., Nicotra F., Scheper W., Flores O.,
Masserini M., Andrieux K., Couvreur P., Versatile and Efficient Targeting Using a Single
Nanoparticulate Platform: Application to Cancer and Alzheimer's Disease, ACSNano, 2012, 6, 7, 58665879.
34. Airoldi C.,* Merlo S., Sironi E., Nicotra F., Jiménez-Barbero J.,* NMR Protein-Ligand Interaction
Studies under Non-Homogeneous Conditions for Biomaterial Generation: A Model For Artificial LectinCarbohydrate Recognition, J. Mater. Sci. Eng. B, 2012, 2 , 12, 618-625.
35. Airoldi C.,* Sironi E., Dias C., Marcelo F., Martins A., Rauter A. P., Nicotra F., Jimenez-Barbero J.,
Natural Compounds against Alzheimer´s Disease: Molecular Recognition of Aβ1–42 Peptide by Salvia
sclareoides Extract and its Major Component, Rosmarinic Acid, as Investigated by NMR, Chem. Asian
J., 2013, 8, 3, 596-602.
36. Airoldi C., Cardona F., Sironi E., Colombo L., Salmona M., Cambianica I., Ornaghi F., Sancini G.,
Nicotra F., La Ferla B., Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for
Alzheimer’s disease, Pure Appl. Chem., 2013, 85, 9, 1813-1823.
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Cristina Airoldi –Publication list
January 2015
37. Gabrielli L., Airoldi C., Sperandeo P., Gianera S., Polissi A., Nicotra F., Cipolla L., Phosphonate
analogues of arabinose 5-phosphate: putative ligands for arabinose 5-phosphate isomerases?, 2013, Eur.
J. Org. Chem., 34, 7776–7784.
38. Airoldi C.,* Merlo S., Sironi E., NMR molecular recognition studies for the elucidation of protein and
nucleic acid structure and function, in e-Book Series on Application of NMR Spectroscopy in
"Molecular Identification", Bentham Science Publishers, USA, 2014, in press.
39. Gabrielli L., Merlo S., Airoldi C., Sperandeo P., Gianera S., Polissi A., Nicotra F., Holler T. P., Woodard
R. W. Cipolla L., Arabinose 5-phosphate isomerase as a target for antibacterial design: studies with
substrate analogues and inhibitors, Bioorg. Med. Chem., 2014, 22, 8, 2576-2583.
40. Cipolla L., Airoldi C., Sperandeo P., Gianera S., Polissi A., Nicotra F., Gabrielli L., Synthesis and
biological evaluation of arabinose 5-phosphate mimics modified at position five, Carb. Res, 2014, in
press.
41. Merlo S., Sironi E., Colombo L., Cardona F., Martorana A. M., Salmona M., La Ferla B., Airoldi C.*
Cis-glyco-fused benzopyran compounds as hit compounds for the development of new therapeutic and
diagnostic
tools
against
10.1002/cplu.201400035.
neurodegenerative
invited
for
a
diseases,
special
issue
ChemPlusChem,
title
“Early
2014,
Career
DOI:
Series”
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2192-6506/homepage/2688_earlycareer.html
42. La Ferla B., Airoldi C., D’Orazio G., 2014, “Curcumin derivatives: Aβ-ligands as potential diagnostic
and therapeutic tools for Alzheimer disease”. In Curcumin, Synthesis, Emerging Role in Pain
Management and Health Implications (pp. 87-101). Daniel Loic Pouliquen.
43. Airoldi C., Mourtas S., Cardona F., Zona C., Sironi E., D’Orazio G., Markoutsa E., Nicotra F.,
Antimisiaris S. G., La Ferla B., Nanoliposomes presenting on surface a cis-glycofused benzopyran
compound display binding affinity and aggregation inhibition ability towards Amyloid β 1-42 peptide,
Eur. J. Med. Chem., 2014, 85, 43-50.
44. Sironi E., Colombo L., Lompo A., Messa M., Bonanomi M., Regonesi M. E., Salmona M., Airoldi C.*,
Natural compounds against neurodegenerative diseases: molecular characterization of the interaction of
catechins from green tea with Aβ1-42, PrP106-126 and ataxin-3 oligomers, Chem. Eur. J., 2014, 20,
13793–13800.
45. Jesus A. R., Dias C., Matos A. M., de Almeida R. F. M., Viana A. S., Marcelo F., Ribeiro R. T., Macedo
M. P., Airoldi C., Nicotra F., Martins A., Cabrita E. J., Jiménez-Barbero J., Pilar Rauter A., 8-β-DGlucopyranosylgenistein: Synthesis, Antidiabetic Activity and Molecular Interaction with Islet Amyloid
Polypeptide and Amyloid β-Peptide (1-42), J. Med. Chem., 2014, 57, 9463–9472.
46. Airoldi C.*, Tripodi F., Guzzi G., Nicastro R., Coccetti P.*, NMR analysis for budding yeast
metabolomics: a rapid method for sample preparation, Molecular Biosystems, 2015, DOI:
10.1039/C4MB00452C.
*corresponding author
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Cristina Airoldi –Publication list
January 2015
Patents:
1. Nicotra F., Airoldi C., La Ferla B., Jimenez-Barbero J., Giovannardi S., NMR based method with HRMAS probe on intact cells. 2010, RM2010A000647; 2011, WO/2012/077087.
2. Nicotra F., Masserini M., La Ferla B., Airoldi C., Cardona F., Sironi E., New tricyclic compounds,
process for their manufacture and their use as ligands of the beta amyloid peptides. 2011,
RM2011A00026; 2012, WO 2012164476 A1.
3. Grases Santos Silva Rauter A. P., Xavier de Jesus A. R., Mendes Martin A. I., dos Santos Dias C. A.,
Tavares Ribeiro R. J., Borges de Lemos Macedo M. P., Guerra Justino J. A., Mota Filipe H. D., Amaro
Pinto R. M., Nogueira Sepodes B. M., Patrício Goulart de Medeiros M. A., Jimenéz Barbero J., Airoldi
C., Nicotra F. New C-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction
with beta-amyloid. Therapeutic applications of the synthesized agent(s) and of Genista tenera ethyl
acetate extracts containing some of those agents, 2012, PT106202; 2013, WO 2013132470 A2.
Other publications:
1. Airoldi C., Global Scientific Challenges: Perspectives from Young Scientists, Chemistry International The News Magazine of the International Union of Pure and Applied Chemistry (IUPAC), 2007, 28, 5,
24-26.
Milano, January 13, 2015
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