Associate Professor Teo Yik Ying
Address: Department of Statistics and Applied Probability, Blk S16, 6 Science Drive 2, National
University of Singapore, Singapore 117546
Email: statyy@nus.edu.sg / ephtyy@nus.edu.sg
Contact no.
Fax no.
: +65-6516 2760
: +65-6872 3919
Academic appointments
Oct 2011 – current Head, Biostatistics Domain, Saw Swee Hock School of Public Health,
National University of Singapore
Programme Leader, Life Sciences Institute, National University of Singapore
Jan 2010 – current
Associate Professor, joint appointments in Department of Statistics & Applied
Probability (Faculty of Science), and Department of Epidemiology & Public
Health (School of Medicine), National University of Singapore
Faculty, NUS Graduate School for Integrative Sciences and Engineering,
National University of Singapore
Adjunct Visiting Group Leader, Genome Institute of Singapore, Agency for
Science, Technology and Research
Apr 2010 – Mar 2012 Scientific Member, National Healthcare Group Domain-Specific Review
Board, Ministry of Health, Singapore
Jan 2010 – Dec 2012 Member, Programme Management Committee, PhD in Biostatistics, National
University of Singapore
Oct 2008 – Dec 2009 Senior Research Fellow, Centre for Molecular Epidemiology, National
University of Singapore
Oct 2006 – Dec 2009 Postdoctoral Statistician, Wellcome Trust Centre for Human Genetics
Oct 2006 – Dec 2009 Associate Lecturer, Department of Statistics, University of Oxford
Oct 2006 – Dec 2009 Visiting Fellow, Department of Statistics and Applied Probability, National
University of Singapore
Jun 2005 – Oct 2006 Departmental Lecturer, Department of Statistics, University of Oxford
Jun 2003 – Oct 2006 Teaching Assistant, Department of Statistics and Applied Probability,
National University of Singapore
Academic records
2006 DPhil., University of Oxford, UK, supervisor: Prof Peter Donnelly FRS.
2001 MSc. Dist., University of Oxford, UK, supervisor: Dr Peter Clifford
2000 BSc. Hons. (1st), Imperial College, UK
Awards and honours
2011
Faculty Teaching Excellence Award, National University of Singapore
2011
Singapore Youth Award (highest accolade in youth for Science and Technology
category), Singapore National Youth Council
2010
Young Scientist Award, Singapore National Academy of Science
2010
National Research Foundation Research Fellowship, Singapore
2008
Teaching Excellence Award, University of Oxford
2007
Exceptional Merit Award, Wellcome Trust Centre for Human Genetics,
University of Oxford
2006
Teaching Excellence Award, University of Oxford
2004 – 2006 Jesus College Graduate Scholarship, University of Oxford
2004 – 2006
2004
2003 – 2006
2003 – 2006
2001
2000 – 2001
2000
2000
1999
1998
1997 – 2000
Overseas Research Student Scholarship Award, United Kingdom
Faculty Teaching Excellence Award, National University of Singapore
Overseas Graduate Scholarship, National University of Singapore
Lee Kuan Yew Postgraduate Scholarship, Public Service Commission (Singapore)
M.Sc. Distinction, University of Oxford, UK
Shell Centenary Scholarship, International Shell Foundation
Sherbrooke Award for Mathematics, University of London
Governor’s Prize for Mathematics, Imperial College
Book Prize for Mathematics, Imperial College
Letter of Commendation for Mathematics, Imperial College
Singapore Government Scholarship, Public Service Commission (Singapore)
Consortium membership
Oct 2007 – current Singapore Genome Variation Project: Chair of overall project group
Oct 2006 – Dec 2009 MalariaGEN Consortium: member of the MalariaGEN Analysis Group
Jan 2006 – Jun 2007 Wellcome Trust Case Control Consortium: member of the Oxford Statistics
Group
Journal editorial board
April 2012 – current Member of International Editorial Board, Siriraj Medical Journal
Nov 2010 – current Review Editor, Frontiers in Statistical Genetics and Methodology
Oct 2011 – current Associated Editor, Human Heredity
Grants awarded
1. Joint PIs: Dr Sarah Dunstan (Australian), A/Prof Teo Yik Ying (Singapore)
Title: The interaction between the host and pathogen genetics in susceptibility to pulmonary
tuberculosis
Grant no.: 12/1/21/24/6689
Funding agency: A*STAR – Australian NHMRC Joint Grant Call 2012
Period: 3 years (18 February 2013 – 17 February 2016)
Amount: S$477,576
Role: Singapore Principal Investigator
2. PI: Prof Saw Seang Mei
Title: Whole exome sequencing to identify genes for extreme myopia in Asian populations
Grant no.: CIRG12may068
Funding agency: National Medical Research Council Singapore
Period: 3 years
Amount: S$1,146,390.28
Role: Co-Investigator
3. Co-PIs: A/Prof Simon Ong Yew Kuang, A/Prof Caroline Lee, A/Prof Teo Yik Ying, A/Prof
Samuel Chong
Title: Development of a tool to predict response of patients to Fluorouracil/Platinum drugs
Grant no.:
Funding agency: Biomedical Research Council – Science and Engineering Research Council
(BMRC-SERC)
Period:
Amount: S$1,349,610
Role: Co-Principal Investigator
4. PI: A/Prof Lai Poh San
Title: Elucidating the genetic and clinical heterogeneity of neuromuscular disorders
Grant no.: EDG11may041
Funding agency: National Medical Research Council Singapore
Period:
Amount: S$188,000
Role: Co-Investigator
5. PI: A/Prof Jie Jin Wang
Title: Interplay of genetic and environmental factors on age-related cataract development
Grant no.: APP1031058
Funding agency: National Health and Medical Research Council Australia
Period: 1st January 2012 – 31st December 2014
Amount: A$210,208.75
Role: Chief Investigator
6. PI: A/Prof Teo Yik Ying
Title: Singapore Natural Variation Project on Integrative Omics (iOmics)
Funding agency: Life Sciences Institute, National University of Singapore
Period: Apr 2011 – Mar 2014
Amount: S$849,600
Role: Principal Investigator
7. Program Director: Dr Su Chi Lim
Title: Novel genetic and non-genetic risk factors for endothelial dysfunction and diabetic microangiopathies
Grant no.:
Funding agency: National Medical Research Council Singapore
Period:
Amount: S$1,990,000
Role: Co-Investigator
8. PI: Dr Belinda Kate Cornes
Title: The genetic determinants of age related macular degeneration in Asian populations – a
comparative genetic study between three major Asian ethnic groups (Chinese, Indians and
Malays) in Singapore
Grant no.: NIG10
Funding agency: National Medical Research Council Singapore
Period: Jul 2010 – Jun 2013
Amount: S$170,288
Role: Mentor to PI of New Investigator Grant
9. PI: A/Prof Yik Ying Teo
Title: Modeling complex interactions in the genetics and genomics of common phenotypes and
infectious diseases
Grant no.: NRF-RF2010-05
Funding agency: National Research Foundation, Singapore
Period: Jul 2010 – May 2015
Amount: S$3,762,350
Role: Principal Investigator
10. PI: Prof Tien Yin Wong
Title: Genetic markers of retinal vascular calibre and cardiovascular disease: The Singapore
Malay Eye Study & The Singapore Prospective Study Programme
Grant no.: BMRC 09/1/35/19/616
Funding agency: Biomedical Research Council (BMRC) – Singapore
Co-investigators: E Shyong Tai, Jianjun Liu, Yik Ying Teo
Period: Jan 2010 – Dec 2012
Amount: S$1,122,000
Role: Co-investigator
11. PI: A/Prof Jie Jin Wang
Title: Genetic associations of early retinal pathologic phenotypes: Data pooling and metaanalyses of multiple populations
Chief investigators: Eric Boerwinkle, Gerald Liew, Pablo Moscato, E Shyong Tai, Alex Hewitt,
John Attia, Yik Ying Teo, Ronald Klein, Patrick McElduff
Associate investigators: Tien Yin Wong, Amirul Isalm, Barbara EK Klein, Paul Mitchell,
Johannes R Vingerling.
Period: Jan 10 – Dec 12
Amount: A$710,763
Role: Chief Investigator
12. Program director: Prof Michael Boehnke
PI: A/Prof Tai E Shyong
Title: Identifying T2D Variants by DNA Sequencing in Multiethnic Samples
Grant no: U01 DK085584
Funding agency: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Period: Oct 09 - Sept 14
Amount: US$672,678
Role: Co-investigator
13. Program director: Prof Mark I McCarthy
PI: Prof Chia Kee Seng
Title: Identifying variants causal for Type 2 Diabetes in major human populations
Grant no: U01 DK085545.
Funding agency: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Period: Oct 09 - Sept 14
Amount: US$77,791
Role: Co-investigator
14. PI: A/Prof Tai E Shyong
Title: Genome-wide case-control studies to identify genetic variants and gene-environment
interactions involved in the pathogenesis of type 2 diabetes mellitus in Chinese, Malays and
Asian Indians living in Singapore
Co-investigators: Kee-Seng Chia, Woon-Puay Koh, Mark Seielstad, Yik-Ying Teo, Mark
Pereira, Daniel O. Stram, Tien-Yin Wong, Su-Chi Lim, Daniel Peng-Keat Ng,
Wern-Ee Tang, Chia-Siong Wong, Myron Gross
Funding agency: NMRC (NMRC/1174/2008)
Period: 23 Jul 08 - Mar 11
Amount: S$1,000,000
Role: Co-investigator
15. PI: Prof Kee-Seng Chia
Title: Singapore Genome Variation Project
Co-PIs: Yik-Ying Teo, Edmund Lee, Mark Seielstad
Funding agency: National University of Singapore
Period: Oct 2007 – Jun 2009
Amount: S$500,000
Role: Co-PI
Grants reviewer
1. Swiss National Science Foundation, Switzerland
Programme/Grant: Swiss National Science Foundation Research Grant
Year: 2009
2. Medical Research Council (MRC), UK
Programme/Grant: MRC Research Grant
Year: 2009
3. Medical Research Council (MRC), UK
Programme/Grant: MRC Career Development Awards in Biostatistics
Year: 2009
4. National Medical Research Council (NMRC), Singapore
Programme/Grant: NMRC Individual Research Grant
Year: 2009
5. National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases
(NIAID), USA
Programme/Grant: International Centers of Excellence for Malaria Research (ICEMR)
Year: 2010
6. Biotechnology and Biomedical Sciences Research Council (BBSRC), UK
Programme/Grant: Technologies and Methodological Development Grant
Year: 2011
7. National Health and Medical Research Council (NHMRC), Australia
Programme/Grant: 2011 Project Grant Funding
Year: 2011
Patents
DP/3507/Genetics Software Suite – Isis Innovation Limited, Oxford, UK
Invited lectures / presentations
2012
- “Sequencing and population genetics in Singapore”
Invited lecture, Asia-Pacific Congress in Human Genetics, Kuala Lumpur, Malaysia
- “Emerging pharmacogenomics approaches to drug discovery”
Invited lecture, World Health Summit 2013, Berlin, Germany
- “Sequencing and population genetics in Singapore”
Invited lecture, Trends in Genomics: 3rd International Biological Information Objects Conference,
Seoul, Korea
- “Public health in the era of genomics”
Invited lecture, 1st Singapore International Public Health Conference, Singapore
- “Deep whole-genome sequencing of populations in Singapore”
Invited lecture, 1st Symposium and Workshop on High-Throughput Data-Driven Biology”,
Bangalore, India
- “Biostatistics Demystified”, and “Common Pitfalls of Statistical Analyses”
Invited lectures, Singapore Physiotherapy Association National Congress 2012, Singapore
- “Investigating the host genetics of malaria in diverse populations”
Invited lecture, Genomic Epidemiology of Malaria 2012, Hinxton, UK
- “Deep whole-genome sequencing of 100 Malays from South-East Asia”
Invited lecture, Illumina Asia-Pacific Scientific Summit, Gold Coast, Australia
- “Unraveling the host genetics of malaria: challenges and opportunities”
Invited lecture, UK-Singapore Infectious Diseases Joint Symposium, Singapore
- “Deep whole-genome sequencing of 100 South-East Asian Malays”
Oral presentation, Human Genome Organisation HUGO 2012, Sydney, Australia
- “Foundational role of statistics in future medicine”
Invited lecture, Singapore Mathematical Society Annual Lecture Series, Singapore
- “Meta-analysis of genome-wide association studies from genetically diverse populations”
Oral presentation, EGG and EAGLE Summit, London, UK
2011
- “The vital role of population genetic variation in establishing the genetic etiology of lipid
metabolism in worldwide populations”
Invited lecture, 5th Congress of the International Society of Nutrigenetics and Nutrigenomics,
Beijing China
- “Genome-wide association studies: past successes, present challenges and future applications”
Invited lecture, Federation of Asian and Oceanian Biochemists and Molecular Biologists 2011
Conference, Singapore
- “From GWAS to Public Health Genomics”
Invited lecture, 6th Singapore Public Health and Occupational Medicine Conference, Singapore
- “Next-generation genome-wide association studies: meta-analysis of genetically diverse
populations”
Invited lecture, International Conference on Mathematical Biology, Bangalore, India
- “Evolution of GWAS: From Discovery to Fine-Mapping to Translation”
Invited lecture, Nature Genetics Workshop at Anhui Medical University: GWAS 2011 –
Opportunities and Challenges, Anhui, China
- “Population genetics and genetic statistics: Updates and current challenges”
Invited lecture, Asia ARVO 2011, Singapore
2010
- “Population genetics and ethnicity”
Invited lecture, 2010 Pharmacogenetics Symposium, Singapore
- “Trans-ethnic fine-mapping of causal variants by leveraging on inter-population variation in
linkage disequilibrium”
Invited lecture, 19th Korea Genome Organisation Conference, Seoul, South Korea
2009
- “Population Structure in Human Genetics”, “Design and Analysis of Genome-wide Association
Studies”, “Meta-analyses, imputation and fine-mapping”
Instructor, Wellcome Trust Advanced Course* on Genomic Epidemiology of Malaria, Hinxton, UK
- “Genome-wide association study of malaria in West Africa: challenges and insights”
Invited speaker, Genetics and Genomics of Infectious Diseases, Singapore
* Instructors for the Wellcome Trust Advanced Courses are considered to be amongst the top
scientists in the relevant field.
2008
- “Genome-wide association study of malaria in Africa: a case-control pilot study in The Gambia”
Invited lecture, Genomic Epidemiology of Malaria, Hinxton, UK
- “Mapping genomic variation in South-East Asia”
Conference presentation, Genomic Disorders, Hinxton, UK
- “Genome-wide association studies in Africa: insights and challenges”
Invited lecture, Molecular Medicine and Genomics in Africa, Khartoum, Sudan
2007
- “Whole genome amplification: insights and implications”
Invited presentation, MalariaGEN Oxford-Sanger Meeting, Oxford, UK
- “Design and analytical issues for a genome-wide association study in a multi-ethnic population”
Invited lecture, Global Enterprise for Micro-Mechanics and Molecular Medicine: Conference on
Cancer, Singapore
- “A genome-wide association study of malaria”
Conference presentation, MalariaGEN 2nd Network Meeting, Hinxton, UK
2006
- “Calling genotypes for Affymetrix 500K SNP arrays: applied to Wellcome Trust Case-Control
Consortium”
Conference presentation, Beyond HapMap, Boston, USA
- “Selecting informative markers for population assignment”
Conference presentation, Keystone Symposia on Human Genetics, Montana, USA
2005
- “Marker selection for population structure in genetic association studies”
Invited presentation, Mathematical Modeling of Infectious Diseases, Singapore
- “Quantifying relative information for population association studies”
Conference presentation, Genomic Studies and the HapMap, Oxford, UK
2003
- “Quantification of regularity – An introduction to ApEn-Bootstrap significance test”
Conference presentation, Symposium of Stochastics and Applications, Singapore
Conference and Course Organisation
- Chair of Organizing Committee. Genetics and Genomics of Complex Phenotypes, Singapore,
26 – 30 April 2010
- Member of Scientific Organizing Committee. Federation of Asian and Oceanian
Biochemistry and Molecular Biology, Singapore. 5 – 7 October 2011
- Member of Local Organizing Committee. XXI International Congress of Genetics and
Human Genome Meeting 2013, Singapore, 14 – 19 April 2013
Journal reviewer
African Journal of Agricultural Research, Bioinformatics, BMC Bioinformatics, BMC Genetics,
British Journal of Ophthalmology, Genetic Epidemiology, Genome Research, Human Heredity,
Journal of Human Genetics, Molecular Biology and Evolution, Pharmacogenomics, PLoS Genetics,
PLoS One
Past PhD students
1. Xueling Sim, National University of Singapore
Period: 2009 – 2012
Current: Postdoc with Prof Michael Boehnke, University of Michigan
2. Rick Twee-Hee Ong, National University of Singapore
Period: 2009 – 2012
Current: Postdoc with A/Prof YY Teo, National University of Singapore
PhD students
1. Qiao Fan, National University of Singapore
Period: Jan 2010 – current
2. Xuanyao Liu, National University of Singapore
Period: Jul 2010 – current
3. Xu Wang, National University of Singapore
Period: Jul 2010 – current
4. Lai Fun Thean, National University of Singapore (Co-supervisor)
Period: May 2010 – current
5. Gengbo Chen, National University of Singapore (Co-supervisor)
Period: Aug 2012 – current
6. Eryu Xia, National University of Singapore
Period: Aug 2012 – current
7. Bowen Li, National University of Singapore
Period: Jan 2013 – current
8. Erwin Tantoso, National University of Singapore
Period: Jan 2013 – current
9. Rita Yong, National University of Singapore (Co-supervisor)
Period: Aug 2009 – current
MSc students
1. Punan Zhang, University of Oxford, 2006
2. Yumeng Wu, University of Oxford, 2007
3. Kanishka Bhattacharya, University of Oxford, 2007
Final Year Project students
1. Huixiang Chua, National University of Singapore, 2011
2. Yuan Sun, National University of Singapore, 2011
3. Wai Yee Yip, National University of Singapore, 2011
4. Winnie Ji Xiang Tiong, National University of Singapore, 2013
Publications
1. Tan EC, Chong SA, Teo YY, Mythily S. (2003) No evidence of molecular heterosis at the dopamine
D2 receptor gene locus for smoking in schizophrenia. American Journal of Medical Genetics B
(Neuropsychiatric Genetics) 120:40-41.
2. Tan EC, Chong SA, Mahendran R, Tan CH, Teo YY. (2003) Mu opioid receptor gene polymorphism
and neuroleptic-induced tardive dyskinesia in patients with schizophrenia. Schizophrenia Research
65:61-63.
3. Tan EC, Chong SA, Tan CH, Teo YY, Peng K, Mahendran R. (2003) Tumor necrosis factor-alpha
gene promoter polymorphisms in chronic schizophrenia. Biological Psychiatry 54:1205-1211.
4. Tan EK, Chai A, Teo YY, Zhao Y, Tan C, Shen H, Chandran VR, Teoh ML, Yih Y, Pavanni R, Wong
MC, Puvan K, Lo YL, Yap E. (2004) Alpha-synuclein haplotypes implicated in risk of Parkinson's
disease. Neurology 62:128-131.
5. Tan EK, Drozdzik M, Bialecka M, Honczarenko K, Klodowska-Duda G, Teo YY, Tang K, Wong LP,
Chong SS, Tan C, Yew K, Zhao Y, Lee CG. (2004) Analysis of MDR1 haplotypes in Parkinson's disease
in a white population. Neuroscience Letters 372:240-244.
6. Tan EC, Chong SA, Lim LC, Chan AO, Teo YY, Tan CH, Mahendran R. (2004) Genetic analysis of the
thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders.
Psychiatric Genetics 14:227-231.
7. Tan EK, Chan DK, Ng PW, Woo J, Teo YY, Tang K, Wong LP, Chong SS, Tan C, Shen H, Zhao Y, Lee
CG. (2005) Effect of MDR1 haplotype on risk of Parkinson disease. Archives of Neurology 62:460464.
8. Tan EC, Chong SA, Wang H, Chew-Ping Lim E, Teo YY. (2005) Gender-specific association of
insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia. Molecular Brain
Research 139:212-216.
9. Pua YH, Koh MT, Teo YY. (2006) Effects of allometric scaling and isokinetic testing methods n the
relationship between countermovement jump and quadriceps torque and power. Journal of Sports
Science 24:423-432.
10. Teo YY, Chong FF. (2006) On the usage of principal components analysis and multiple testing.
American Journal of Respiratory and Critical Care Medicine 173: 574.
11. Tan EK, Lu ZY, Fook-Chong SM, Tan E, Shen H, Chua E, Yih Y, Teo YY, Zhao Y. (2006) Exploring an
interaction of adenosine A2A receptor variability with coffee and tea intake in Parkinson’s disease.
American Journal of Medical Genetics B (Neuropsychiatric Genetics) 141:634-636.
12. Teo YY, Fry AE, Clark TG, Tai ES, Seielstad M. (2007) On the usage of HWE for identifying
genotyping errors. Annals of Human Genetics 71: 701-703.
*13. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott
KS, Lango H, Rayner NW et al. (2007) A common variant in the FTO gene is associated with body
mass index and predisposes to childhood and adult obesity. Science 316:889-894.
*14. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB,
Rayner NW, Freathy RM et al. (2007) Replication of genome-wide association signals in U.K.
samples reveals risk loci for Type 2 diabetes. Science 316:1336-1341.
*15. The Wellcome Trust Case-Control Consortium. (2007) Genomewide association study of
14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678.
16. Teo YY, Inouye M, Small KS, Gwilliam R, Deloukas P, Kwiatkowski DP, Clark TG. (2007) A
genotype calling algorithm for the Illumina BeadArray platforms. Bioinformatics 23: 2741-2746.
17. Wellcome Trust Case Control Consortium & The Australo-Anglo-American Sponylitis
Consortium. (2007) Association scan of 14,500 nonsynonymous SNPs in four diseases identifies
autoimmunity variations. Nature Genetics 39:1329-1337.
18. Tan EK, Chua E, Fook-Chong S, Teo YY, Yuen Y, Tan L, Zhao Y. (2007) Association between
caffeine intake and risk of Parkinson’s disease among fast and show metabolizers.
Pharmacogenetics Genomics 17:1001-1005.
19. Tan EK, Lee J, Chen CP, Teo YY, Zhao Y, Lee WL. (2009) SORL1 haplotypes modulate risk of
Alzheimer’s disease in Chinese. Neurobiology of Aging 30:1048-1051.
20. Calis JCJ, Phiri KS, Faragher EB, Brabin BJ, Bates I, Cuevas LE, de Haan RJ, Phiri AI, Malange P,
Khoka M, Hulshof PJM, van Lieshout L, Beld MGHM, Teo YY, Rockett KA, Richardson A, Kiwatkowski
DP, Molyneux ME, van Hensbroek MB. (2008) Factors associated with severe anemia in Malawian
children. New England Journal of Medicine 358:888-899.
21. Teo YY, Small KS, Clark TG, Kwiatkowski DP. (2008) Perturbation analysis: a simple method for
filtering SNPs with erroneous genotyping in genome-wide association studies. Annals of Human
Genetics 72:368-374.
22. Teo YY. (2008) Common statistical issues in genome-wide association studies: a review on
power, data quality control, genotype calling and population structure. Current Opinion in
Lipidology 19:133-143.
23. Teo YY, Inouye M, Small KS, Fry AE, Potter SC, Dunstan SJ, Seielstad M, Barroso, I, Wareham NJ,
Rockett KA, Kwiatkowski DP, Deloukas P. (2008) Whole genome amplified DNA: insights and
imputation. Nature Methods 5:279-280.
24. Tan EC, Lim Y, Teo YY, Goh R, Law HY, Sia AT. (2008) Ethnic differences in pain perception and
patient-controlled analgesia usage for postoperative pain. The Journal of Pain 9:849-855.
25. Sia AT, Lim Y, Lim EC, Goh RW, Law HY, Landau R, Teo YY, Tan EC. (2008) A118G single
nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and
patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean
analgesia. Anesthesiology 109:520-526.
26. Teo YY, Fry AE, Pederson B, Small KS, Sanjoaquin MA, Rockett KA, Kwiatkowski DP, Clark TG.
(2008) Assessing genuine parents-offspring trios for genetic association studies. Human Heredity
67:26-37.
27. Thuong NTT, Dunstan SJ, Chau TTH, Thorsson V, Simmons CP, Quyen NTH, Thwaites GE, Lan
NTN, Hibberd M, Teo YY, Seielstad M, Aderem A, Farrar JJ, Hawn TR. (2008) Identification of
tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathogens
4:e1000229.
28. The Malaria Genomic Epidemiology Network. (2008) A global network for investigating the
genomic epidemiology of malaria. Nature 456:732-738.
29. Teo YY, Small KS, Fry AE, Wu Y, Kwiatkowski DP, Clark TG. (2009) Power consequences of
linkage disequilibrium variation between populations. Genetic Epidemiology 33:128-135.
30. Tan EK, Lu CS, Peng R, Teo YY, Wu-Chou YH, Chen RS, Weng YH, Chen CM, Fung HC, Tan LC,
Zhang ZJ, An XK, Lee-Chen JG, Lee M, Fook-Chong S, Burgunder JM, Wu RM, Wu YR. (2010) Analysis
of the UCHL1 genetic variant in Parkingson’s Disease among Chinese. Neurobiology of Aging
31:2194-2196.
**31. Jallow M+, Teo YY+, Small KS+, et al. (2009) Genome-wide and fine-resolution association
analysis of malaria in West Africa. Nature Genetics 41:657-665.
32. Clark TG, Diakite M, Auburn S, Campino S, Fry AE, Green A, Richardson A, Small K, Teo YY,
Wilson J, Jallow M, Sisay-Joof F, Pinder M, Griffiths MJ, Peshu N, Williams TN, Marsh K, Molyneux
ME, Taylor TE, Rockett KA, Kwiatkowski DP. (2009) Tumour necrosis factor and lymphotoxin alpha
polymorphisms and severe malaria in African populations. Journal of Infectious Diseases 199:569575.
33. Clark TG, Fry AE, Auburn S, Campino S, Diakite M, Green A, Richardson A, Teo YY, Small K,
Wilson J, Jallow M, Sisay-Joof F, Pinder M, Sabeti P, Kwiatkowski DP, Rockett KA. (2009) Allelic
heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility. European
Journal of Human Genetics 17:1080–1085.
34. Fry AE, Ghansah A, Small KS, Palma A, Auburn S, Diakite M, Green A, Campino S, Teo YY, Clark
TG, Jeffreys A, Wilson J, Jallow M, Sisay-Joof F, Pinder M, Griffiths MJ, Peshu N, Williams TN,
Newton CR, Marsh K, Molyneux ME, Taylor TE, Koram KA, Oduro AR, Rodgers WO, Rockett KA,
Sabeti P, Kwiatkowski DP. (2009) Positive selection of a CD36 nonsense variant in sub-Saharan
Africa, but no association with severe malaria phenotypes. Human Molecular Genetics 18:26832692.
35. Teo YY. (2009) Exploratory data analysis in large-scale genetic studies. Biostatistics 11:70–81.
36. Teo YY, Small KS. (2009) A novel method for haplotype clustering and visualization. Genetic
Epidemiology 34:34-41.
37. Holt KE, Teo YY, Li H, Nair S, Dougan G, Wain J, Parkhill J. (2009) Detecting SNPs and estimating
allele frequencies in clonal bacterial populations by sequencing pooled DNA samples.
Bioinformatics 15:2074-2075.
38. Teo YY, Fry AE, Small KS, Kanishka B, Kwiatkowski DP, Clark TG. (2009) Genome-wide
comparisons of variation in linkage disequilibrium. Genome Research 19:1849-1860.
39. Tan EK, Teo YY, Prakash KM, Li R, Lim HQ, Angeles DC, Tan L, Au WL, Yih Y, Zhao Y. (2009)
LINGO1 variant increases risk of familial Essential Tremor. Neurology 73:1161-1162.
40. Tan EC, Lim ECP, Teo YY, Lim Y, Law HY, Sia AT. (2009) Ethnicity and OPRM variant
independently predict pain perception and patient-controlled analgesia usage for post-operative
pain. Molecular Pain 5:32.
41. Teo YY+, Sim XL+, Ong RTH+, Tan AKS, Chen J, Tantoso E, Small KS, Ku CS, Lee EJD, Seielstad M,
Chia KS. (2009) Singapore Genome Variation Project: A haplotype map of three South-East Asian
populations. Genome Research 19:2154-2162.
42. Teo YY, Small KS, Kwiatkowski DP. (2010) Methodological challenges of genome-wide
association analysis in Africa. Nature Review Genetics 11:149-160.
43. Teo YY, Sim X. (2010) Patterns of linkage disequilibrium in different populations: Implications
and opportunities for lipid-associated loci identified from genome-wide association studies. Current
Opinion in Lipidology 21:104–115.
44. Tan EK+, Peng R+, Teo YY+, Tan L, Angeles D, Ho P, Chen ML, Lin CH, Mao XY, Prakash KM, Liu JJ,
Au WL, Le WD, Jankovic J, Burgunder JM, Zhao Y, Wu RM. (2010) Multiple LRRK2 variants modulate
risk of Parkinson’s Disease: a multicenter study in Chinese. Human Mutation 31:561–568.
45. Ong RTH, Teo YY. (2010) varLD: A program for quantifying variation in linkage disequilibrium
patterns between populations. Bioinformatics 26:1269–1270.
46. Kariuki S, Revathi G, Kiiru J, Mengo DM, Mwituria J, Muyodi J, Munyalo A, Teo YY, Holt KE,
Kingsley RA, Dougan G. (2010) Typhoid in Kenya is associated with a dominant multidrug resistant
Salmonella Typhi haplotype that is also widespread in South East Asia. Journal of Clinical
Microbiology 48:2171–2176.
47. Yu YD, Choi Y, Teo YY, Dalby AR. (2010) Developing stochastic models for spatial inference:
bacteria chemotaxis. PLoS One 5:e10464.
48. Ku CS, Pawitan Y, Sim X, Ong RT, Seielstad M, Lee EJ, Teo YY, Chia KS, Salim A. (2010) Genomic
copy number variations in three Southeast Asian populations. Human Mutation 31:851–857.
49. Clark TG, Campino SG, Anastasi E, Auburn S, Teo YY, Small K, Rockett KA, Kwiatkowski DP,
Holmes CC. (2010) A Bayesian approach using covariance of SNPs data to detect differences in
linkage disequilibrium patterns between groups of individuals. Bioinformatics 26:1999–2003.
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* Contributed as a member of the Statistics group in Oxford for the Wellcome Trust Case-Control
Consortium (WTCCC) – responsible for the design of statistical methodologies to analyse data from
the genome-wide association studies. Other WTCCC publications exist but are not included as there
were no explicit contributions made to these work.
** Co-led the analysis and a member of the writing committee.
+
Joint first authors.
++
Joint last authors.