Wednesday, August 2, 2006 7-9:00 p.m. Vet Med Instructional Facility, UCD Campus Reception and Speaker/Poster Presenter Preparations SCIENTIFIC PROGRAM Thursday, August 3, 2006 7-8:00 a.m. 8:00 a.m. SESSION I: 8:10 a.m. 9:00 a.m. 9:25 a.m. 9:50 a.m. 10:15 a.m. SESSION II: 10:35 a.m. 11:00 a.m. 11:25 a.m. 11:45 a.m. 12:05 p.m. 1:00 p.m. SESSION III: 2:00 p.m. 2:25 p.m. 2:50 p.m. 3:15 p.m. 3:40 p.m. 4:00 p.m. 106742087 Schalm Hall, UCD Campus Continental Breakfast & Registration (speakers finish loading talks) Official Welcome: Niels Pedersen, UC Davis and Steve Hannah, Nestle Purina PetCare THE FELINE GENOME Chair: Marilyn Menotti-Raymond Keynote: The Domestic Cat Genome Sequence – Annotation and Comparative Inference Steve O’Brien Assembly and building the physical map of the cat genome sequence Jim Mullikin A Third Generation Linkage Map of the Domestic Cat; Application of Domestic Cat Linkage and RH Maps to the Positional Cloning and Character Marilyn Menotti-Raymond Positional mapping of the feline spinal muscular atrophy locus implicates a novel disease gene in motor neuron maintenance John Fyfe BREAK THE CANINE GENOME Chair: Francis Galibert Trait mapping using a canine SNP array Kerstin Lindblad-Toh A comprehensive linkage map of the dog genome Mark Neff Identification of new canine genes: the value of comparative genomics Christophe Hitte Genomic imprinting in the canine, a new model organism for studying genomic imprinting Fiona O’Sullivan LUNCH POSTER SESSION in new VMIF, all authors of odd numbered posters present GENETIC ANALYSIS OF COMPLEX TRAITS Chair: Lorna Kennedy Genetics of sweet taste in the carnivores Xia Li Polymorphism and functional studies of olfactory receptor canine genes Francis Galibert Genetic analysis of hip dysplasia at two loci in the domestic dog Pascale Quignon Canine MHC associations with immune mediated diseases including diabetes, polyarthritis and hypothyroidism Lorna Kennedy Adjourn Board shuttles directly to Railroad Museum for Wine Reception in Old Sacramento (Dinner on your own). Shuttles return to Davis approx. 10:00pm SCIENTIFIC PROGRAM continued Friday, August 4, 2006 Schalm Hall, UCD Campus 7-8:00 a.m. Continental Breakfast SESSION IV: ORIGINS AND PHYLOGENY Chair: Elaine Ostrander 8:00 a.m. Keynote: Understanding the Genetics of Complex Traits in the Domestic Dog Elaine Ostrander 8:50 a.m. Recent Advances in Understanding the Evolutionary History of the Felidae Warren Johnson 9:15 a.m. Evolutionary Genomics of the Dog and Dog-Like Carnivores Robert K. Wayne 9:40 a.m. Comparison of 120 dog breeds from the US and UK by SNP genotyping identifies breed and geographic gene pool differences Paul Jones 10:05 a.m. BREAK SESSION V: COMPARATIVE GENOMICS BETWEEN BREEDS AND SPECIES Chair: Bill Murphy 10:25 a.m. Understanding breed relationships facilitates genetic studies of complex traits Heidi Parker 10:50 a.m. DLA Class II Diversity and Relationships among Indigenous Dogs of the Island Nations of Indonesia (Bali), Australia and New Guinea Niels Pedersen 11:15 a.m. A 1.5 Mb resolution feline RH comparative map and the evolution of novel Y chromosome genes in the cat and dog genomes Bill Murphy 11:40 a.m. MHC SNPs in the Domestic Cat Naoya Yuhki 12:05 p.m. LUNCH 1:00 p.m. POSTER SESSION in new VMIF, all authors of even numbered posters present SESSION VI: GENETICS OF SINGLE GENE TRAITS (1) Chair: Urs Giger 2:00 p.m. Localization of the genetic defect in the Landseer dogs with a bleeding disorder by a genome wide screen of 1500 SNPs Peter Leegwater 2:25 p.m. Genetic analysis and mapping of primary hyperparathyroidism in Keeshonden Richard Goldstein 2:50 p.m. A Common Missense Mutation Causing Factor VII Deficiency in the Beagle, Alaska Klee Kai and Scottish Deerhound Urs Giger 3:15 p.m. A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy Kathryn Meurs 3:40 p.m. BREAK. 4:00 p.m. From 24 to 2 candidate genes: Pinpointing the Dalmatian hyperuricosuria locus using linkage disequilibrium Noa Safra 4:20 p.m. A missense mutation in the canine ortholog of the human ATF2 in Standard Poodles with a fetal Neonatal Encephalopathy Gary Johnson 4:40 p.m. Type IV collagen gene expression in canine hereditary nephropathy (HN) and identification of mutation causative for HN in the English Cocker spaniel Rebecca Bell 5:00 p.m. Adjourn. Shuttle back to hotels before picnic (starts at 6:15 p.m. at Buehler Alumni Center) BBQ Picnic & Live Entertainment. Shuttles return guests periodically to host hotels. 106742087 SCIENTIFIC PROGRAM continued Saturday, August 5, 2006 Schalm Hall, UCD Campus SESSION VII: GENETICS OF CANINE AND FELINE MORPHOLOGY Chair: John Fondon 7:30-8:30 a.m. 8:30 a.m. Continental Breakfast Keynote: QTLs and Genome Architecture Gordon Lark Divergent contributions of slippage mutation to dog and cat genetic variation and evolution John W. Fondon, III Canine polydactyl mutations with heterogeneous origin are found in the conserved intronic sequence of C7orf2 gene Chankyu Park BREAK 9:20 a.m. 9:45 a.m. 10:10 a.m. SESSION VIII: GENETICS OF SINGLE GENE TRAITS (2): Chair: Barbara Zangerl 10:30 a.m. Chromosomal localization of an inherited craniofacial defect in the cat Carolyn Erdman 10:55 a.m. Different mutations within HSF4 are associated with recessive and dominant forms of hereditary cataract in different breeds of dog Cathryn Mellersh 11:20 a.m. Novel Retinal Gene (PRCD) Causes Progressive Rod-Cone Degeneration in Canines and Humans Barbara Zangerl 11:45 a.m. Identification of a mutation in the CHAT gene associated with Canine Congenital Myasthenic Syndrome (cCMS) in Old Danish Pointing dogs Helle Proschowsky 12:10 p.m. LUNCH 1:15 p.m. Browsing the Cat Genome Using Generic Genome Browser Joan Pontius SESSION IX: GENETICS OF COAT COLOR Chair: Keith Murphy 1:30 p.m. Two-Stage Association mapping in dogs identifies coat color locus Elinor Karlsson 1:55 p.m. The long and short of it: Evidence that FGF5 is a major determinant of canine hair-itability Donna Housley 2:20 p.m. The Genetics of Merle Patterning in the Domestic Dog Keith Murphy 2:45 p.m. BREAK SESSION X: CLINICAL APPLICATIONS OF GENOMICS - ADVANCES Chair: Leslie Lyons 3:05 p.m. Gene Therapy in Cats with lysosomal storage diseases Mark Haskins 3:30 p.m. Canine molecular cytogenetic resources: Development and application to studies of canine cancers Matthew Breen 3:55 p.m. Genetic resources in cats and dogs for common mammalian diseases Leslie Lyons 4:20 p.m. Molecular cytogenetic evaluation of canine tumors Rachel Thomas 4:45 p.m. Closing Remarks Niels Pedersen 5:00 p.m. 106742087 Meeting Adjourns