Principal Investigator/Program Director
(Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME OF SPONSOR (CO-SPONSOR)
POSITION TITLE
Martin David Tilson
Professor of Surgery (Columbia University) 1989-present
, EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
Grad
BA
MD
1959
1963
1967
Graduate, Valedictorian
Philosophy, summa cum laude
Texarkana High School, Texarkana, Texas
Rice University, Houston, Texas
Yale University, New Haven, CT
Medicine
Previous Positions
Intern and Resident in Surgery
Yale New Haven Hosp & Yale Univ
Instructor in Surgery
Yale University School of Medicine
Military Service: USAF Hospital
SAC Command ,Westover Air Force Base
Assistant Professor of Surgery
Yale University School of Medicine
Associate Professor of Surgery
Yale University School of Medicine
Chief, Division of Vascular Surgery Yale-New Haven Hospital & Yale Univ
Professor of Surgery
Yale University School of Medicine
Director of Surgery
St. Luke's Roosevelt HC, New York
Ailsa Mellon Bruce Prof Surgery
Columbia University
Honors
Blanche White Honor Scholar, Rice University
Phi Beta Kappa
President, Hanszen College, Rice University
Ferris Prize for Excellent Work in Anatomy , Yale Univ School Med
Alpha Omega Alpha
Ramsey Prize for Unquestioned Ability and Character, Yale Univ School Med
RG Cowper Visiting Professor, Univ N Carolina
James IV Traveler
Governor, American College of Surgeons
Halsted Society
Who's Who in America, Marquis, 50th Edition to present
Evan’s Fellow, Visiting Scientist in Residence, Dunedin, New Zealand
Who's Who in World, Marquis
Living Legends, International Biography Centre, Cambridge, UK
Selected Professional Societies
American Surgical Association
American College of Surgeons
International Society for CV Surgery
Society of University Surgeons
New England Society for Vascular Surgery
New England Surgical Society
Society for Surgery of the Alimentary Tract
Society for Vascular Surgery
Other Distinctions
Editorial Board, Journal of Vascular Surgery (Emeritus)
1967-1972
1971-1972
1972-1974
1974-1978
1978-1983
1983-1989
1983-1989
1989-1995
1989-present
1960-1962
1962
1962-1963
1964
1966
1966
1981
1985
1986-1988
1988-present
1996-present
1998
2003-present
2003-present
Most recently, NIH Study Section, Special Emphasis Panel ZRG1 EDC-1 (50), Bethesda, Jul 30, 2003
PHS 398/2590 (Rev. 05/01)
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Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle):
B. Selected peer-reviewed publications (in chronological order) (note page limit, this page only)
(note, numbering by MedLine)
4. Tilson, M.D. and Wright, H.K. Adaption of functioning and bypassed segments of ileum during compensatory
hypertrophy of the gut. Surgery 67:687-693, 1970.
14. Tilson, M.D. Compensatory hypertrophy of the gut: Testing of the tissue mass, intraluminal nutrition, and functional
demand hypotheses. Arch. Surgery. 104:69-72, 1972.
48. Tilson, M.D. and Stansel, H.C. Differences in results for aneurysms vs.occlusive disease after bifurcation grafts:
results of 100 elective grafts. Arch. Surgery 115:1173-1175, 1980.
62. Tilson, M.D. and Seashore, M.R. Human genetics of the AAA. Surg. Gyn. Obs. 158:129-132, 1984.
63. Tilson, M.D. and Seashore, M.R. Fifty families with abdominal aneurysms in two or more first-order relatives.
Amer. J. Surg. 147:551-553, 1984.
67. Tilson, M.D. Further studies of a putative crosslinking amino acid (3-deoxy-pyridinoline) in skin from patients with
abdominal aortic aneurysms. Surgery, 98:888-891, 1985.
73. Brophy, C.E., Tilson J.E., Braverman, I.M., Tilson, M.D. Age of onset, pattern of distribution and histology of
aneurysm development in a genetically predisposed mouse model. J. Vasc. Surg., 8:45-48, 1988.
82. Brophy C.M., Sumpio B., Reilly J.M., Tilson M.D. Electrophoretic characterization of protease expression in
aneurysmal aorta: report of a unique 80kDa elastolytic activity. Surg. Res. Comm.10:315-321,1991.
84. Brophy C.M., Reilly J.M., Smith G.J.W., Tilson M.D. The role of inflammation in nonspecific abdominal aortic
aneurysm disease. Ann. Vasc. Surg., 5:229-233, 1991.
91. Irizarry E, Newman KM, Gandhi RH, Nackman GB, Halpern V, Wishner S, Scholes JV, Tilson MD. Demonstration
of interstitial collagenase in AAA disease. J Surgical Research 54:571-574, 1993.
94. Halpern VJ, Nackman GB, Gandhi RH, Irizarry E, Scholes JV, Ramey WG, Tilson MD. The elastase infusion model
of experimental aortic aneurysms: Synchrony of induction of endogenous proteinases with matrix destruction and
inflammatory cell response. J Vasc Surgery, 20:51-60, 1994
98. Jean-Claude J, Newman KM, Li H, Tilson MD. Possible key role for plasmin in the pathogenesis of abdominal aortic
aneurysms. Surgery, 1994; 116:472-8.
99. Newman KM, Malon AM, Shin RD, Scholes JV, Ramey WG, Tilson MD. MMP’s in abdominal aortic aneurysm:
Characterization, Purification, and their possible sources. Conn Tissue Res, 1994, 30:265-276.
100. Newman KM, Ogata Y, Malon AM, Irizarry E, Gandhi RH, Nagase H, Tilson MD. Identification of matrix
metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm. Arteriosclerosis and
Thrombosis, 1994; 14: 1315-1320.
101. Newman KM, Jean-Claude J, Li H, Scholes JV, Ogata Y, Nagase H, Tilson MD. Cellular localization of matrix
metalloproteinases in the abdominal aortic aneurysm wall. J Vascular Surgery, 1994; 20: 814-20.
104. Tilson MD. Similarities of an autoantigen in aneurysmal disease of the human aorta to a 36-kDa microfibrilassociated bovine aortic glycoprotein. Biochem Biophys Research Comm 1995; 213: 40-43.
105. Gregory AK, Yin NX, Capella J, Xia S, Newman KM, Tilson MD. Features of autoimmunity in the abdominal
aortic aneurysm. Arch Surg, 1996, 131: 85-88.
106. Xia S, Ozsvath K, Hirose H, Tilson MD. Partial amino acid sequence of a novel 40 kDa human aortic protein, with
vitronectin-like, fibrinogen-like, and calcium binding domains: Aortic aneurysm associated protein-40 (AAAP-40) .
Biochem Biophys Res Communications 1996, 219: 36-39.
113. Capella JF, Paik DC, Yin NX, Gervasoni JE, Tilson MD. Complement activation and subclassification of tissue
immunoglobulin G in the abdominal aortic aneurysm. J Surg Research 1996; 65: 31-33.
117. Paik DC, Ramey WG, Dillon J, Tilson MD. The nitrite/elastin reaction:implications for in vivo degenerative effects.
Connective Tissue Research 1997; 36:241-251.
119. Hirose H, Ozsvath KJ, Xia S, Gaetz HP, Tilson MD. Immunoreactivity of matrix fibrils of normal and aneurysmal
abdominal aorta with antibodies against vitronectin and fibrinogen. Pathobiology, 1998; 66: 1-4.
121. Borromeo JRM, Koshy N, Park WM, Xia S, Hardy K, Tilson MD. Regional distribution in the mouse of proteins
homologous to artery-specific antigenic proteins. J Surg Res 1999; 85: 217-224.
122. Chew DKW, Knoetgen James III, Xia S, Gaetz HP, Tilson MD. Regional distribution in human of a novel aortic
collagen-associated microfibrillar protein. Exp Mol Path 1999; 66: 59-65.
124. Tilson MD, Fu C, Xia S, Syn D, Yoon Y, McCaffrey T. Expression of molecular messages for angiogenesis by
fibroblasts from AAA versus dermal fibroblasts. Int J Surg Investig. 2000;1(5):453-7.
130. Tilson MD. Public awareness of aortic aneurysm. Cardiovasc Surg. 2001 Aug;9(4):311-2.
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Principal Investigator/Program Director (Last, First, Middle):
C. Research Support. List selected ongoing or completed (during the last three years) research projects (federal
and non-federal support). Begin with the projects that are most relevant to the research proposed in this
application. Briefly indicate the overall goals of the projects and your role (e.g. PI, Co-Investigator, Consultant) in
the research project.
1999-2003 - N.I.H. - RO1-HL-64334-01-04
Principal Investigator
"Autoimmune aortic antigens in abdominal aortic aneurysm."
This grant has been the only extramural support for the laboratory of Dr. Tilson over the time period captionedabove. Substantial acquistion of experimental data has been accomplished, much of which is summarized in the
following section . Manuscripts describing these results are in preparation, and some are already in editorial
review. In addition, thirteen complete or partial cDNA sequences (which may be significant in the
pathobiology of AAA disease) have been reported to GenBank during this period of support. These files are
also noted below. The funding period for this grant lapses on Sep 30, 2003; and the PI has no new proposals
either funded or pending, except for the present application with PI Joseph Ianelli.
RECENT INTERNATIONAL / NATIONAL PRESENTATIONS : 2000-2003
Syn D, Hardy K, Xia S, Tilson MD. A molecular hypothesis for the
phenomenon of generalized arteriomegaly and/or peritoneal inflammation in
some patients with abdominal aortic aneurysms. J. Surg Res 2000; 93:
365.
Bhatti A, Ewing DR, Jordan TP, McCaffrey TA, Gefen JY, Tilson MD. Role of
collagen type XI in the pathogenesis of the abdominal aortic aneurysm.
Presented at ACS Surgical Forum, San Francisco, Oct 2002. J Amer Coll
of Surgeons 2002; 195. 3 (supplement): page S201.
Tilson MD. The spreadsheet of aortic aneurysm associated proteins (AAAP's)
grows wider and longer. Presented at Second Grantees' Meeting: Abdominal
Aortic Aneurysm Pathogenesis, Bethesda, Nov 2002. Program and Abstract
Booklet, Nov 2002, pages 25-27.
Wellner RB, Bhatti AF, Jordan T, Xia SX, Tilson MD. Searches for the
genomic origins of two mesenchymal gene products with Ig-like domains
lead to the nasopharygeal carcinoma gene (NPC) on Chromosome 2p12.
First Annual Meeting of the Amer Soc Matrix Biology, Houston, Nov 2002.
Program and Abstract Booklet, Nov 2002, page 192.
Tilson MD. What is the etiology of abdominal aortic aneurysm and what genes
are involved? 20th World Congress of the International Union of Angiology,
New York, April 2002. Program and Abstract Booklet, page 2.
Bhatti AF, Tilson MD, Gefen JY, Syn D, Ewing DR, Jordan TP. Site- and
tissue-specific expression of aortic aneurysm antigenic proteins (AAAP's)
in-situ (immunohistochemistry) and in-vitro (cultured fibroblasts).
13th Annual Meeting of the Society for Vascular Medicine
and Biology, Boston, June 7-9, 2002. Syllabus Book, pages 253-254.
Jordan TP, Bhatti AF, Li XG, Obunike JC, Tilson MD. Aneurysmal diseases
cosegregate in an African-American kindred with HLA Class II DR-B1-15.
Presented at the Annual Meeting of the International College of Angiology,
New York, June 20 - Jul 3,2002. Abstract Book.
Tilson MD. Germline sequence of an aortic aneurysm antigenic protein (AAAP)
and the evolutionary origins of HIV envelope glycoprotein GP 120.
Presented at the Annual Meeting of the International College of Angiology,
New York, June 20 - Jul 3,2002. Abstract Book, page 4.
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Principal Investigator/Program Director (Last, First, Middle):
Jordan TP, Li XG, Bhatti AF, Obunike JC, Tilson MD. Expression of a ferritinlike mRNA by abdominal aortic aneurysm (AAA) adventitial fibroblasts.
Proceedings of the 36th Annual Meeting of the Association for Academic
Surgery, Nov 7-9, 2002, Boston, Mass; page 11.
Chew DK, Knoetgen J III, Tilson MD. The role of a putative microfibrillar
protein (80 kDa) in Abdominal Aortic Aneurysm disease.
Proceedings of the 36th Annual Meeting of the Association for Academic
Surgery, Nov 7-9, 2002, Boston, Mass; page 11.
Wellner RB, Xia S, Tilson MD. Similarity of a ligand for HIV gp 120 and an amino
acid sequence in Mat-CAM-1. Presented, Society of University Surgeons, February,
Houston, Texas. 2003
Belsey S, Li XG, Obunike JC, Tilson MD. Polymorphism of the gene for C1QRp
may play a role in the pathogenesis of abdominal aortic aneurysms. Submitted,
Surgical Form, Amer College of Surgeons, Oct 2003.
Jordan TP, Bhatti AF, Tilson, MD. Progress toward a simple blood test for
aneurysm susceptibility based on the sequences of an aortic aneurysm antigenic
protein (AAAP) (in preparation).
Tilson MD. Harmony prevails when bedside observations resonate with laboratory bench
research. in abdominal aortic aneurysm disease. Lecture, Karolinska Institute,
Stockholm, Sweden. Jan 30, 2003.
Belsley S, Tilson MD. Mutation of 3 nucleotides in ferritin-light chain, chromosome
19q13, resulting in three amino acid substitutions, from fibroblasts of patient with
abdominal aortic aneurysm (in prepraration.).
DNA SEQUENCES REPORTED TO GENBANK BY TILSON LAB
1: AY207005 Homo sapiens ferritin-like protein mRNA, complete. gi28894134|gb|AY207005.1|[28894134]
2: AF186176 Homo sapiens microfibrillar protein with Ig-like domain 1 precursor RNA, partialsequence
gi|15277410|gb|AF186176.2|AF186176[15277410]
3: AY039026 Homo sapiens hypothetical protein mRNA, complete gi|15081581|gb|AY039026.1|[15081581]
4: AY039025 Homo sapiens putative matrix cell adhesion molecule-3 mRNA, complete cds
gi|15081579|gb|AY039025.1|[15081579]
5: AF391807 Human abdominal aortic adventitia from an aneurysm specimen Homo sapiens cDNA clone 34a, MRNA sequence
gi|15072231|gb|AF391807.1|[15072231]
6: AF391806 AF391806 Human abdominal aortic adventitia from an aneurysm specimen Homo sapiens cDNA clone 40w, MRNA sequence
gi|15072230|gb|AF391806.1|[15072230]
7: AF391804 Human abdominal aortic adventitia from an aneurysm specimen Homo sapiens cDNA clone 35a, MRNA sequence
gi|15072229|gb|AF391804.1|[15072229]
8: AF391803 Human abdominal aortic adventitia from an aneurysm specimen Homo sapiens cDNA clone 32a, MRNA
sequencegi|15072228|gb|AF391803.1|[15072228]
9: AF391802 Human abdominal aortic adventitia from an aneurysm specimen Homo sapiens cDNA clone 24-79, MRNA sequence
gi|15072227|gb|AF391802.1|[15072227]
10: AF391801 Human abdominal aortic adventitia from an aneurysm specimen Homo sapiens cDNA clone 34w, MRNA sequence
gi|15072226|gb|AF391801.1|[15072226]
11: AF391805 Homo sapiens clone 35w unknown mRNA; mitochondrial gene for mitochondrial product
gi|15055161|gb|AF391805.1|AF391805[15055161]
12: AF391800 Homo sapiens aortic aneurysm antigenic protein clone 4 mRNA, partial,
gi|15055159|gb|AF391800.1|AF391800[15055159]
13: AF206020 Homo sapiens microfibrillar protein 2 mRNA, partial cds
gi|7417002|gb|AF206020.1|AF206020[7417002]
D. Completed Research Support (all with Dr. Tilson as Principal Investigator)
1982-1985 - N.I.H. - RO1-HL-29325-01-03 "Causes of aneurysms in mutant mice and surgical patients."
1985-1988 - N.I.H. - R01-HL-29325-04-06 "Causes of aneurysms in mutant mice and surgical patients."
1990-1993 - N.I.H. - R01-HL-29325-07-09
"Inhibition of proteolysis in aortic aneurysm disease"
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