Last data updates: 06 January 2011
Han, N.L., Luo, F., Bian, Z.P. and Han, J.S. (2000), Synergistic effect of cholecystokinin
octapeptide and angiotensin II in reversal of morphine induced analgesia in rats. Pain, 85 (3),
465-469.
Document type: Article Language: English Cited references: 27 Time cited: 10 Times self cited: 0
Abstract: The aim of this paper is to study the synergistic anti-analgesic effect of angiotensin II
(Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous studies have shown that both
CCK-8 and Ang LT are potent anti-opioid substances. Intracerebroventricular (i.c.v.) injection of
CCK-8 or Ang II dose-dependently antagonizes morphine-induced analgesia (MIA). In the present
study, we observed the combined effect of CCK-g and Ang II in antagonizing MIA. CCK-8 and
Ang II were injected intracerebroventricularly to rats in various proportions and doses. The results
were analyzed with isobolographic analysis. Combined injection of CCK-8 and Ang II in a ratio of
1 ng: 2.5 mu g or 1 ng: 5 mu g produced significantly greater effect in antagonizing MIA. The
ED50 Of the two ratios are only 18.5% and 27.5%, respectively, of the theoretical dose of simple
addition. We conclude that CCK-8 and Ang II used in such dose ratios may antagonize MIA
synergistically. (C) 2000 International Association for the Study of Pain. Published by Elsevier
Science B.V. All rights reserved.
Author Keywords: morphine induced analgesia; cholecystokinin octapeptide; angiotensin II;
intracerebroventricular injection; synergistic effect
Keywords Plus: Nucleus-Accumbens; Opioid Agonists; Calcium; Mu; Combinations; Mobilization;
Habenula; Neurons
Reprint Address: Han, JS (reprint author), Beijing Med Univ, Neurosci Res Inst, Beijing 100083,
Peoples R China
Addresses:
1. Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2. Yian Bei Nursing Sch, Dept Physiol, Datong, Shanxi Peoples R China
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