What Areas of the Face Can Be Treated with Perlane®? The hyaluronic acid in Perlane® can be used to improve the contour of facial skin and to reduce wrinkles, folds, scars, and other facial skin depressions. Common uses for Perlane® filler include: Wrinkle correction Diminishing worry lines, smile lines, crow’s feet, marionette lines at corners of the mouth, and smoker’s lines Lip enhancement Reducing the severity of nasolabial folds Chin augmentation Filling cheek depressions Redefining lip border Softening acne scars Other, less common, uses for Perlane® filler include: Filling hollows under the eyes Creating a temporary eyebrow lift Correcting facial depressions caused by fat loss Softening the appearance of jowls Restylane® vs. Perlane® Filler Perlane® is primarily the same product as Restylane®, but Perlane® filler contains a larger concentration of hyaluronic acid. Because of this higher concentration of hyaluronic acid, Perlane® is usually used for larger folds, while Restylane® is better suited for smaller wrinkles or to maintain the results of a previous Perlane® injection. Because of the differing levels of hyaluronic acid, Restylane® is less expensive than Perlane® filler.