Derek A. Wainwright, Ph.D.
Professional Summary
Education:
2009-Pres.
Post-Doctoral Fellow (Department of Surgery: The Brain Tumor Center),
University of Chicago, Chicago, IL – Concentration(s): Neuro-Oncology /
Immunotherapy (Mentor: Dr. Maciej S. Lesniak, M.D.)
2004-2009
Doctorate of Philosophy (Cell Biology, Neurobiology and Anatomy), Loyola
University Chicago, Chicago, IL – Concentration: Cell Biology / Neuroscience /
Immunology (Mentor: Dr. Kathryn J. Jones, Ph.D.)
2002-2004
Master of Science (Cell Biology, Neurobiology and Anatomy), Loyola
University Chicago, Chicago, IL – Concentration: Orthopedics
(Mentor: Dr. Frederick H. Wezeman, Ph.D.)
1998-2002
Bachelor of Science (Biology), Bradley University, Peoria, IL
[Mentor: Dr. Samuel Fan, Ph.D. (1954-2010)]
1998-2001
SICU Unit secretary/Nursing Assistant/EKG Technician, Trinity Medical
Center, Rock Island, IL
Professional Profile
Post-Doctoral Fellow, University of Chicago, The Brain Tumor Center
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Mentored neurosurgeons, neurosurgery residents and medical students
Published research manuscripts on neuro-oncology and immunotherapy
Vice President, University of Chicago Postdoctoral Association
Member of professional scientific societies; elected to serve on committees
Received independent support from the National Institutes of Health (NINDS)
Bred and created novel transgenic mouse strains
Multi-project management and co-ordination with a publication schedule
Delivered international award-winning seminars
Established and managed collaborations
Oversaw an operating budget
Performed complex small animal surgeries and dissections
Doctorate of Philosophy, Loyola University Chicago, Department of
Cell Biology, Neurobiology and Anatomy
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2009-Present
2004-2009
Teaching Assistant (Medical Histology) – Directed by Dr. John Clancy Jr.
Teaching Assistant (Advanced Neurobiology) – Directed by Dr. Keith N. Fargo
Wrote and published manuscripts
Outlined, produced and presented lectures locally and nationally to scientific audiences
Managed research projects related to neurodegenerative disease/injury
Performed complex small animal surgeries and dissections
Coordinated complex transgenic mouse collaborations with other major medical
Home Address: 8140 West 26th Street, North Riverside, IL 60546;
Phone: (309)236-8525; Email:derekwainwright@hotmail.com
Work Address: 5801 South Ellis Avenue, Chicago, IL 60637;
Mobile: (309)236-8525; Email:dwainwr@surgery.bsd.uchicago.edu
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Derek A. Wainwright, Ph.D.
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centers
Received independent support from the Les Turner ALS Foundation
Independently wrote and submitted federally required animal use protocols
Wrote and published a dissertation
Master of Science, Loyola University Chicago, Department of
Cell Biology, Neurobiology and Anatomy
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Departmental graduate representative
Medical center graduate representative to the all-school graduate council
Managed research projects related to osteoporosis
Performed complex small animal surgeries and dissections
Wrote and published a thesis
Bachelor of Science, Bradley University, Department of Biology
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Leadership:
2002-2004
2002-2004
2010-Pres.
2010
2011
2011-Pres.
2011
2011
1998-2002
First chair in the Symphonic Band
Performer in the Peoria Symphony Orchestra
Speech team (ranked 1st in the nation) award winner
Research focused on Drosophila fruit fly development
SICU Unit secretary/Nursing Assistant/EKG Technician,
Trinity Medical Center
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2002-2004
1998-2001
Receptionist/secretary for the MICU and SICU
Maintained accurate EKG records of patients
Routinely gave 12-lead EKGs
Bathed patients
Assisted physicians during in-room procedures
Processed and entered physician orders
Took BPs via stethoscope and processed blood gases
Maintained in-unit pharmacy stores
Transported patients throughout the hospital
Departmental representative to the Graduate Student Council
Graduate Student Council representative to the Medical Student Council
Member, American Association of Anatomists – Membership Committee
Session Chair, Stress and Immunity: 3rd Annual Brain, Behavior and Immunity
Conference, Chicago, IL, USA
Invited Panelist, Loyola University Chicago Career Development Series Speaker,
“To Do, or Not To Do, THE POST-DOC!”, Chicago, IL, USA
Member, American Association of Anatomists – Public Affairs Committee
Invited Speaker, Riverdale High School Commencement Address, Port Byron,
IL, USA http://www.youtube.com/watch?v=haaDFIi4dO4
Invited Panelist, American Association of Anatomists – Strategic Thinking for
Undergraduate Recruitment Task Force, Washington D.C., USA
Home Address: 8140 West 26th Street, North Riverside, IL 60546;
Phone: (309)236-8525; Email:derekwainwright@hotmail.com
Work Address: 5801 South Ellis Avenue, Chicago, IL 60637;
Mobile: (309)236-8525; Email:dwainwr@surgery.bsd.uchicago.edu
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Derek A. Wainwright, Ph.D.
2011-Pres.
2011
2012-Pres.
2012
2012-Pres.
2012
2012-Pres.
2012
Honors
2008
2008
2010
2011
2011
2012
2012
Chair, The University of Chicago Post-Doctoral Association – Public Affairs
Committee
Session Chair, Nutrition, Exercise and Stress: 4th Annual Brain, Behavior and
Immunity Conference, Chicago, IL, USA
Member, National Post-Doctoral Association – Advocacy Committee
Invited Panelist, University of Chicago Post-Doctoral Association Career
Development Series: Grant Writing Panel, “Tips for a successful fellowship
application”
Vice-President, University of Chicago Biological Sciences Division Postdoctoral
Association.
Session Chair, Brain Tumor Immunotherapy: 18th Annual Neuro-Tumor Club
Dinner Meeting at AACR, Chicago, IL, USA
Co-Organizer, 6th Annual Brain, Behavior and Immunity Conference, Chicago,
IL, USA [The 2013 meeting]
Invited Panelist, Forward Focus Workshop: Strategic Planning for the NIH
Common Fund, Sponsored by the National Institutes of Health, Elk Grove, IL,
USA
(Runner-Up) American Association of Anatomists – National Langman Graduate
Student Platform Presentation, Experimental Biology, San Diego, CA, USA
(Travel Award) American Association of Anatomists, Experimental Biology, San
Diego, CA, USA
(1st Place) The Department of Surgery 17th Annual Charles B. Huggins Research
Symposium Poster Presentation Competition, The University of Chicago,
Chicago, IL, USA
(1st Place) Abstract Book Cover Art: Inaugural Post-Doctoral Association
Symposium, The University of Chicago, Chicago, IL, USA
(1st Place) The Department of Surgery 18th Annual Charles B. Huggins Research
Symposium Poster Presentation Competition, The University of Chicago,
Chicago, IL, USA
(Travel Award) American Association of Anatomists, Experimental Biology,
Washington D.C., USA
(Runner-Up) American Association of Anatomists – National Postdoctoral
Fellow Platform Presentation, Experimental Biology, San Diego, CA, USA
Professional Memberships:
American Association of Anatomists (AAA); Congressional Liaison Committee; National
Association for Biomedical Research; American Association for the Advancement of
Science (AAAS); Society for Neuroscience (SFN); The Psychoneuroimmunology Research
Society (PNIRS); The National Postdoctoral Association (NPA); Society for Neuro-Oncology
(SNO).
Lab Skill:
Western blot, in vitro cell culture, laser microdissection, CD4+ T cell differentiation (e.g.
Th1/Th2), IACUC protocol writing, enzyme assays, cell death assays, in vivo neuron survival
analyses, ELISA, FACS, FACS analysis software, mouse/rat surgeries and gross dissection
including removal of brains, cervical lymph nodes, spleen, and thymus, transgenic mouse model
breeding and work (e.g. FoxP3-GFP, Mut3, Rag2-/-, TLR2-/-, CCR3-/-, IDO-/-), RNA/DNA/ protein
Home Address: 8140 West 26th Street, North Riverside, IL 60546;
Phone: (309)236-8525; Email:derekwainwright@hotmail.com
Work Address: 5801 South Ellis Avenue, Chicago, IL 60637;
Mobile: (309)236-8525; Email:dwainwr@surgery.bsd.uchicago.edu
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Derek A. Wainwright, Ph.D.
extraction and quantification, RT-PCR, immunohistochemistry, immunocytochemistry, coimmunofluorescence (up to 6-color confocal microscopy), light and fluorescent microscopy,
cryosectioning, protein purification, animal reconstitutions adoptive transfers, immunotherapeutic
antibody administration, microarray analysis, analysis of neuron survival (in vivo).
Peer-Reviewed Scientific Manuscripts
1.
Wainwright DA, Xin J, Sanders VM, Jones KJ. 2008 Differential actions of pituitary
adenylyl cyclase activating polypeptide and interferon gamma on Th2- and Th1-associated
chemokine expression in cultured murine microglia. Journal of Neurodegeneration and
Regeneration. 1(1):31-38. PMID: 20448827
2.
Xin J, Wainwright DA, Serpe CJ, Sanders VM, Jones KJ. 2008 Phenotype of CD4+ T
cell subsets that develop following facial nerve axotomy. Brain Behavior and Immunity.
22(4):528-37. PMID: 18024079
3.
Wainwright DA, Xin J, Mesnard NA, Sanders VM, Jones KJ. 2009 Th2- and Th1associated chemokine expression facial motor nucleus after facial nerve transection in a
presymptomatic murine model of mSOD1. Journal of Neurodegeneration and Regeneration.
2(1):39-44. PMID: 20436785
4.
Wainwright DA, Xin J, Sanders VM, Jones KJ. 2009 Effects of facial nerve axotomy on
Th2- and Th1-associated chemokine expression in the facial motor nucleus of wild-type and presymptomatic mSOD1 mice. Journal of Neuroimmunology. 216(1-2):66-75. PMID: 19818514
5.
Wainwright DA, Xin J, Mesnard NA, Beahrs TR, Sanders VM, Jones KJ. 2009
Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice. ASN
Neuro. e00024. PMID: 19922414
6.
Wainwright DA, Xin J, Sanders VM, Jones KJ. 2010 Toll-like receptor 2 and facial
motoneuron survival after facial nerve axotomy. Neuroscience Letters. 471(1):10-14. PMID:
20056129
7.
Klarquist J, Denman CJ, Hernandez C, Wainwright DA, Strickland FM, Overbeck A,
Mehrotra S, Nishimura MI, Le Poole C. 2010 Reduced skin homing by functional Treg in
vitiligo. Pigment Cell Melanoma Res. 23:276-286. PMID: 20175879
8.
Ahmed AU, Rolle CE, Tyler MA, Han Y, Sengupta S, Wainwright DA, Balyasnikova
IV, Ulasov IV, Lesniak MS. 2010 Bone marrow mesenchymal stem cells loaded with an
oncolytic adenovirus suppress the anti-adenoviral immune response in the cotton rat model.
Molecular Therapy. 18(10): 1846-56. PMID: 20588259
9.
Sengupta S, Nandi S, Wainwright DA, Hindi ES, Han Y, Lesniak MS. 2010. shRNAmediated fibronectin knockdown delays tumor growth in a mouse glioma model. Neoplasia.
12(10):837-47. PMID: 20927322
10.
Xin J, Wainwright DA, Serpe CJ, Sanders VM, Jones KJ. 2010 IL-10 within the CNS is
necessary for CD4+ T cells to mediate neuroprotection. Brain, Behavior and Immunity. 25(5):
820-9. PMID: 20723599
11.
Wainwright DA, Sengupta S, Han Y, Lesniak MS. 2010 The presence of IL-17A and T
helper 17 cells in experimental mouse brain tumors and human glioma. PLoS One. 23(10):
e15390. PMID: 21060663
12.
Wainwright DA, Balyasnikova IV, Han Y, Lesniak MS. 2011. BST2 in experimental
mouse brain tumors and human glioma. Experimental and Molecular Pathology. 91(1): 440-6.
PMID: 21565182
13.
Thaci B, Ulasov IV, Wainwright DA, Lesniak MS. 2011. The Challenge for Gene
Therapy: The Innate Immune Response to Adenoviruses. Oncotarget. 2(3):113-21. PMID:
21399236
Home Address: 8140 West 26th Street, North Riverside, IL 60546;
Phone: (309)236-8525; Email:derekwainwright@hotmail.com
Work Address: 5801 South Ellis Avenue, Chicago, IL 60637;
Mobile: (309)236-8525; Email:dwainwr@surgery.bsd.uchicago.edu
4
Derek A. Wainwright, Ph.D.
14.
Wainwright DA, Sengupta S, Han Y, Lesniak MS. 2011. Thymus-derived rather than
tumor induced regulatory T cells predominate in brain tumors. Neuro-Oncology. 13(12):1308-23.
PMID: 21908444
15.
Xin J, Wainwright DA, Mesnard NA, Beahrs TR, Serpe CJ, Alexander T, Sanders VM,
Jones KJ. 2011. CD4+ T cell-mediated neuroprotection is independent of T cell-derived BDNF in
a mouse facial nerve axotomy model. Brain, Behavior and Immunity. In press. PMID: 22426430
16.
Wainwright DA, Nigam PN, Thaci B, Dey M, Lesniak MS. 2011. Recent developments
on immunotherapy for brain cancer. Expert Opinion on Emerging Drugs. 17(2):181-202. PMID:
22533851
17.
Balyasnikova IV, Wainwright DA, Solomaha E, Lee G, Han Y, Thaci B, Lesniak MS.
2012. Development, characterization and implications for a novel antibody that targets the tumor
specific antigen, IL-13R2, with high affinity. Journal of Biological Chemistry. Under Review.
18.
Wainwright DA, Balyasnikova IV, Chang AL, Ahmed AU, Moon K, Auffinger B, Han
Y, Lesniak MS. 2012. IDO expression in brain tumors increases the recruitment of regulatory T
cells and negatively impacts survival. Clinical Cancer Research. Under Review.
Oral Abstracts (selected from > 15)
1.
Investigation of chemokines responsible for CD4+ T cell-mediated neuroprotection in a
mSOD1 mouse model and facial nerve axotomy. 40th American Society for Neurochemistry,
Charleston, SC, USA. 2009
2.
The role of regulatory T cells in malignant glioma. 2nd Annual Brain, Behavior and
Immunity Conference, Chicago, IL, USA. 2009.
3.
Malignant glioma recruits multiple types of immune cells to the brain with non-classical
molecular phenotypes: relevance to treating neuroinflammation in CNS tumors. 3rd Annual
Brain, Behavior and Immunity Conference, Chicago, IL, USA, 2010.
4.
Regulating tumor immunity in the brain: IDO takes center stage. 4th Annual Brain,
Behavior and Immunity Conference, Chicago, IL, USA, 2011.
5.
Tumor-Derived IDO Affects the Lifespan in a mouse model of glioblastoma.
Experimental Biology, San Diego, CA, USA, 2012.
6.
Investigating the role of IDO in an experimental mouse brain tumor model. 18th Annual
Neuro-Tumor Club Dinner Meeting (Sponsored by the Society for Neuro-Oncology) during
the American Association for Cancer Research Annual Meeting, Chicago, IL, USA, 2012.
7.
IDO expression suppresses anti-tumor immunity through a T cell-dependent mechanism.
th
17 Annual Society for Neuro-Oncology Scientific Meeting. Washington D.C., USA, 2012.
Poster Abstracts (selected from > 20)
1.
Wainwright DA*, Han Y, Lesniak MS. The role of indoleamine 2,3 dioxygenase in a
mouse model of malignant glioma. Society for Neuroscience. Washington D.C., USA. 2011.
(*Poster Presenter)
2.
Vasilopoulos T, Kristjansdottir K, Bergerson R, Wainwright DA*. From Paper to
Practice: Using Survey Results to Improve the Postdoctoral Experience at the University of
Chicago. National Postdoctoral Association Annual Meeting. San Francisco, CA, USA. 2012.
(*Poster Presenter)
3.
Wainwright DA*, Balyasnikova IV, Ahmed A, et al. Upregulation of indoleamine 2,3
dioxygenase in brain tumors is associated with decreased survival through a T cell-dependent
mechanism. 19th Annual Psychoneuroimmunology Research Meeting. San Diego, CA, USA,
2012. (*Poster Presenter)
Home Address: 8140 West 26th Street, North Riverside, IL 60546;
Phone: (309)236-8525; Email:derekwainwright@hotmail.com
Work Address: 5801 South Ellis Avenue, Chicago, IL 60637;
Mobile: (309)236-8525; Email:dwainwr@surgery.bsd.uchicago.edu
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Derek A. Wainwright, Ph.D.
Research Support:
Ongoing Research Support
F32NS073366-01A1
Wainwright (PI)
2011 – 2014
NIH/NINDS
Title: The Role of IDO and Th17 in an experimental mouse model of glioma.
Role: PI
$152,766
Clinical Research Loan Repayment Program
2012 – 2013
PENDING
NIH/NCI
Title: The Role of IDO and Th17 cells in Human GBM and Mouse Models That Recapitulate
Brain Tumors.
Role: PI
Completed Research Support
Young Investigator Award
Wainwright (Co-PI)
2006 – 2009
$150,000
Les Turner ALS Foundation
Title: The Mechanism of Immune Cell Recruitment to the Central Nervous System Following
Peripheral Nerve Axotomy Using a Murine Model of ALS.
Role: Co-PI
Home Address: 8140 West 26th Street, North Riverside, IL 60546;
Phone: (309)236-8525; Email:derekwainwright@hotmail.com
Work Address: 5801 South Ellis Avenue, Chicago, IL 60637;
Mobile: (309)236-8525; Email:dwainwr@surgery.bsd.uchicago.edu
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