2nd School of Medicine Postgraduate Research Day Thursday 11th December 2008 Education Centre, Adelaide & Meath Hospital Dublin, Incorporating the National Children’s Hospital, Tallaght Programme 9.00am Registration, Foyer, Education Centre 9.30am Introduction & Welcome Dr. Thomas Connor, Director of Postgraduate Teaching & Learning 9.35am Research in the School of Medicine Dr. Aiden Corvin, Director of Research SESSION ONE Chair: Dr. Thomas Connor, Department of Physiology Dr. Aideen Long, Department of Clinical Medicine 9.45am Translational Research in Ireland Dr. Ruth Barrington, CEO, Molecular Medicine Ireland 10.15am The flaky tail phenotype (ft) is caused by a homozygous frameshift mutation in the murine filaggrin gene and lead to enhanced cutaneous allergen priming Sean Saunders, Department of Clinical Medicine 10.30am Nuclear receptor-mediated expression of CYP3A4 and CYP2B6 by antiretrovirals - implications for prediction of drug interaction potential and genetic variability in PXR, MDR-1, CYP3A4 and CYP2B6 in HIV infected Caucasian and Sub-Saharan African patients - benefits from a cohort approach Jenny Svard, Department of Pharmacology & Therapeutics 10.45am Hepatic inflammatory gene expression and the development of obesityinduced insulin resistance in IL-1R1 knock out mice Orla Finucane, Department of Clinical Medicine 11.00am COFFEE BREAK/POSTER DISPLAY SESSION TWO Chair: Professor Des O’Neill, Department of Medical Gerontology Professor Marina Lynch, Department of Physiology 11.30am The β2-adrenoceptor agonist clenbuterol activates astrocytes and reduces amyloid-β concentrations and RAGE expression in rat cortex and hippocampus Karen Ryan, Department of Physiology 11.45am Short-term environmental enrichment enhances object recognition memory and increases the concentration of nerve growth factor, but not brain derived neurotrophic factor, in the dentate gyrus of male Wistar rats Amy Birch, Department of Physiology 12.00pm An Investigation into the Effects of Ursodeoxycholic acid on the Golgi Apparatus Ruchika Sharma, Department of Clinical Medicine 12.15pm Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid Janis Noonan, Department of Physiology 12.30pm ABCD scoring by non-vascular neurologists for risk stratification following suspected TIA is frequently inappropriate and inaccurable Justin Kinsella, Department of Clinical Medicine 12.45pm IL-1 receptor type 1 knockout mice fed a high-fat diet are partially protected from an obesity-induced insulin resistance state Elizabeth Oliver, Department of Clinical Medicine 1.00pm LUNCH/POSTER DISPLAY SESSION THREE Chair: Dr. John Gormley, Department of Physiotherapy Dr. Aine Kelly, Department of Physiology 2.00pm Autonomic dysfunction: A biomarker of cognitive decline/dementia? Orla Collins, Department of Medical Gerontology 2.15pm Antimicrobial resistance mechanisms in clinical isolates of Pseudomonas Aeruginosa Sarah Molan, Department of Clinical Microbiology 2.30pm The use of novel fluorescent magnetic nanocomposites for biomedical applications Joseph Gallagher, Department of Physiology 2.45pm Molecular characterisation of antimicrobial resistant bacteraemic Escherichia coli isolates from an Irish hospital Niamh Cooke, Department of Clinical Microbiology 3.00pm Identifying Blood Pressure Response Subtypes Following Orthostatis Using Pattern Recognition Techniques Ciaran Finucane, Department of Medical Gerontology 3.15pm Polymorphisms in Oxytocin Receptor and CD38 genes and Autism: Association and Functional Studies Katherine Tansey, Department of Psychiatry 3.30pm COFFEE BREAK/POSTER DISPLAY SESSION FOUR Chair: Dr. Joe Barry, Department of Public Health & Primary Care Ms. Eilish McAuliffe, Health Policy & Management 4.00pm Effects of carbohydrate versus carbohydrate protein ingestion on subsequent resistance training performance in male rugby players Colin Coyle, Department of Physiology 4.15pm Changing illness beliefs in poorly controlled Type 2 Diabetes: RCT of a psychological, family-based intervention Karen Keogh, Department of Public Health & Primary Care 4.30pm Development of Neural Stem Cell Therapy for Parkinson’s Disease Dr. Maeve Caldwell, School of Medicine, University of Bristol 5.00pm WINE RECEPTION