CURRICULUM VITAE
Carol P. Moreno Quinn, M.D., Ph.D.
Assistant Professor
Department Of Physiology
Human and Molecular Genetics Center
Medical College of Wisconsin
OFFICE ADDRESS: Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, Wisconsin 53226
Phone:
(414) 456-4475
Fax:
(414) 456-6595
E-mail:
quinn@mcw.edu
Web: http://hmgc.mcw.edu/
EDUCATION:
1995
M.D. Universidad de Murcia, Murcia, Spain
1999
Ph.D. Physiology/Pharmacology, Universidad de Murcia, Spain
2008
Faculty Leadership Development Program
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
2000–2002
Postdoctoral Fellow, Department of Physiology
Medical College of Wisconsin, Milwaukee, WI
(Richard J. Roman).
2002–2004
Postdoctoral Fellow, Human and Molecular Genetics
Center, Medical College of Wisconsin, Milwaukee, WI.
(Howard J. Jacob)
FACULTY APPOINTMENTS (INCLUDE SECONDARY AND ADJUNCT
APPOINTMENTS):
2004 – present
Assistant Professor, Department of Physiology, Medical
College of Wisconsin, Milwaukee, WI
RESEARCH ADMINISTRATIVE APPOINTMENTS:
1
2003–2009
2010- 2011
2009-2011
AWARDS AND HONORS:
1996–1999
Consultant, Physiogenix, Milwaukee, WI
Senior Study Director, Physiogenix, Milwaukee, WI
Chief Editor, Frontiers in Genomic Physiology
Predoctoral Fellowship Award, Spanish Ministry
of Education
1999
Short Visit Research Award, Spanish Ministry
of Education
1999
Short Visit Research Award, Merck-Spanish
Society of Hypertension
2001
Postdoctoral Fellowship Award, Fundacion
Seneca, Spain
2001–2003
Postdoctoral Fellowship Award, Spanish Ministry
of Education
2001
Caroline Tum Suden Professional Opportunity
Award, American Physiological Society
2002
Aventis Pharma New Investigator Travel Award,
American Heart Association
2003
APS Travel Award: Understanding Renal and
Cardiovascular Function through Physiological
Genomics
2005
IUPS Travel Award
2005
Fellow of the American Heart Association
2006
Star Reviewer 2005. APS and Physiological Genomics
2009
New Investigator Award. American Physiological Society
Water and Electrolyte Section.
2009
NIH Travel Award. Genetics of Urologic Malformations
2011
Star Reviewer 2010. APS and Physiological Genomics
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
American Physiological Society
2
Spanish Society of Hypertension
American Heart Association
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Chief Editor
2009-2011 Frontiers in Genomic Physiology
Editorial Board
2007-present
Journal Reviewer
2000-present
Editorial Board. Physiological Genomics
Reviewer. Physiological Genomics
Reviewer. Hypertension
Reviewer. Hypertension Research
Reviewer. AJP-Renal Physiology
Reviewer. Trends in Genetics
Reviewer. Nature Genetics
Reviewer. JASN
Reviewer. Pediatric Nephrology
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
Grant Reviewer:
2005
Canine Health Foundation
2007
Children Research Institute. Medical College of
Wisconsin
2009
National Heart Lung and Blood Institute Special
Emphasis Panel. National Institute of Health
Committes:
2009-2012
American Society of Physiology Physiological Genomics
Steering Committee.
2007
World Congress of Microcirculation Scientific
Committee.
2007
World Congress of Microcirculation Organizing
Committee.
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE
POSITIONS:
Grant Reviewer:
2005
Czech Science Foundation
2006
NEST. Sixth Framework Program. European
Commission
2007
FP7-KBBE-2007. Seventh Framework Program.
European Commission
3
2010
2011
Republic of Croatia Ministry of Science, Education and
Sport “Unity through knowledge fund”.
FP7-PEOPLE-2011-IRSES. European Commission
Committes:
2006
Croatian Symposium of Hypertension Scientific
Committee.
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Research Project Collaboration:
A. Active
Peer Review
Title:
Genetic and Physiological Basis of Salt-Induced Hypertension
Source:
NIH/NHLBI
Role:
Principal Investigator project 2 (20% effort), co-investigator project 3 (10%
effort) and Core B Co-Director (15% Effort)
Dates:
August 1, 2006 - July 30, 2011
Direct Funds:
$2,661,920
Title:
Source:
Role:
Dates:
Direct Funds:
Mechanistic Characterization of Genes for Hypertension & Renal Disease
NIH/NHLBI
Co-Investigator. 15% effort
September 30, 2009 - September 29, 2011
$5,308,060 (total for all years)
Title:
Source:
Role:
Dates:
Direct Funds:
Knock-out Rats for Physiological Genomics
NIH/NHLBI
Co-Investigator
September 30, 2009 - July 31, 2011
$7,673,396
Non-Peer Review
Title:
Source:
Role:
Dates:
Direct Funds:
B. Pending
Peer Review
Title:
Source:
Role:
Development funding
Department of Physiology and Human and Molecular Genetics Center
Startup Funds for personnel support and lab supplies
May 1, 2011 – June 30, 2013
$80,000/year
Renin and Angiogenesis in the SS Rat
NIH/NHLBI
Co- Investigator (10% Effort)
4
Dates:
Direct Funds:
October 1, 2011 – September 31, 2016
$ 3,671,112 (total for all years)
Title:
Genetic & Physiological Basis of Salt-induced Hypertension
Source:
NIH/NHLBI
Role:
Genomics and Transgenic Core Director. 50% effort.
Dates:
October 1, 2011 - September 31, 2016
Direct Funds:
$ 7,498,705 (total for all years).
Note: Received an overall score of 2 (within the funding range) in the Parental Committee
C. Completed
Peer Review
Title:
Source:
Role:
Dates:
Direct Funds:
Creation of a Rat Model of Barth Syndrome
Barth Syndrome Foundation
Principal Investigator
June 1, 2008 – February 28, 2010
$36,364
Title:
Source:
Role:
Dates:
Direct Funds:
P50. Integrative Biology of Childhood Kidney Disease
NIH/NIDDK
Principal Investigator of P&F Project
October 1, 2008 - May 31, 2009
$121,800
Title:
Source:
Role:
Dates:
Direct Funds:
Development of an animal model of ARPKD for therapy testing
Children’s Research Institute. Medical College of Wisconsin
Co-Investigator
February 1, 2006 - May 31, 2008
$58,246
Title:
Source:
Role:
Dates:
Direct Funds:
SCOR-Molecular Genetics of Hypertension: Cores B & C
NIH/NHLBI
Co-Investigator
February 1, 2001 - May 31, 2006
$6,568,050
Non-Peer Review
Title:
Source:
Role:
Dates:
Direct Funds:
Systems Biology Program in Cardiovascular Disease
Advancing Healthier Wisconsin
Co-Investigator. 25% effort
December 1, 2008 – February 28, 2011
$745,676
5
INVITED LECTURES/WORKSHOPS/PRESENTATIONS (must be invited to participate):
International
Oral communication: “Activity of tissular NO synthase in the response to acute and chronic increments
of Angiotensin II”. 4 ª National Meeting of SEH-LELHA. Sevilla, Spain. March 1999.
Invited talk: “Risk factors, prevention and treatment of type 2 diabetes”. Workshop in education for
Health. Ibermutuamur and Comunidad Autónoma de la Región de Murcia. Spain. October 1999.
Session Co-Chair: “Inflammation. Cellular Injury”. 9th National Meeting of SEH-LELHA. Murcia,
Spain. March 2004.
Poster Session Chair: 9th National Meeting of SEH-LELHA. Murcia, Spain. March 2004.
Invited talk: "Application of genomics to the study of salt-sensitive hypertension”. University of
Murcia, Spain. March 2005.
Oral communication: “Existence of Multiple Blood Pressure loci on Rat Chromosome 13 of the Dahl
S Hypertensive Rat”. European Meeting on Hypertension. Madrid, June 2006.
Invited talk: "Dissecting the genetic architecture of salt-sensitive hypertension". First International
Symposium on Hypertension: From Laboratory Bench to Clinical Settings, from 25.-28. Osijek,
Croatia August 2006.
Oral communication: “Characterization of blood pressure and protein excretion in
chromosome 18 congenic strains of Dahl S rats”. Rat Genome & Models Meeting. Melbourne.
Australia. December 2006.
Oral communication: “Modeling cardiovascular disease in rat by ENU mutagenesis”. 21st International
Mammalian Genome Conference. Kyoto, Japan. October 2007.
Oral communication: “Characterization of the renin knockout rat“. Rat Genomics and Models. Kyoto,
Japan, December 2010.
Invited talk: “Functional Gene Validation in the Rat”. EUCOMM meeting. Munich, Germany. January
2011.
National
Oral communication: “Gender differences in the genetic determinants of hypertension”. Council for
High Blood Pressure Research. Orlando, Florida. September 2002.
Invited talk: "Physiological Genomics in the Study of Hypertension”. Louisiana State University. New
Orleans, Louisiana. November 2005.
Oral communication: “Concordance of allele characterization project data with SNP distribution across
rat strains”. Rat Genomics and Models Symposium. Cold Spring Harbor. December 2005.
6
Invited talk: ” Rat Consomic Panels and ENU Mutagenesis”. Program of Genomics Application
Traveling Tutorial. Birmingham, Alabama, September 2006.
Oral communication: “Characterization of blood pressure and protein excretion in chromosome 18
congenic strains of Dahl S rats”. Council for High Blood Pressure Research. San Antonio, Texas.
September 2006.
Invited talk: “Translational Genomics in the Study of Complex Diseases”. Merck. New Jersey.
October 2006.
Oral communication: “Linking the Framingham Heart Study and the Program for Genomic
Applications at the Medical College of Wisconsin”. Clinical Cardiovascular Genomics. Cold Spring
Harbor, NY. September 2007.
Oral communication: “Pleiotropic effects of the renin loci”. Rat Genomics and Models. Cold Spring
Harbor, NY, December 2007.
Invited talk: ” The Genetics of Complex Disease”. Program of Genomics Application Traveling
Tutorial. Case Western University. Cleveland, Ohio. April 2008.
Invited talk: ” Translating animal models to the clinic setting”. Program of Genomics Application
Traveling Tutorial. Case Western University. Cleveland, Ohio. April 2008.
Invited talk: ” Genomic strategies for dissecting cardiovascular disease”. New Investigator Award talk
for the APS Water and Electrolyte section, Louisiana. April 2009.
Invited talk: ” Integrative Tools for Gene Discovery in Hypertension Research” Indianapolis. October
2009.
Invited talk: ” Genomic strategies for dissecting complex diseases”. Toledo, OH. November 2009.
Oral communication: “Narrowing the blood pressure loci around the renin gene. Rat Genomics and
Models. Cold Spring Harbor, NY. December 2009.
Session Co-Chair and organizer: “Featured Topic: ‘Molecular mechanisms and genetics of
hypertension’. Experimental Biology, Anaheim CA. April 2010.
Invited talk: Renal Hemodynamics: Mechanisms to Understand Disease FASEB Summer Research
Conference. Vermont. June 2010.
Invited talk: 5th International Scientific, Medical and Family Barth Syndrome Conference. Panama
City Beach, FL. July 2010.
Oral communication: “Characterization of the Renin Knockout Rat“. Council for High Blood Pressure
Research. Washington DC. October 2010.
7
Oral communication: “Characterization of Nap5 KO rat for blood pressure and associated
phenotypes“. Experimental Biology. Washington DC. April 2011.
Session Chair and organizer: “Featured Topic: ‘Trainee Highlights in Physiological Genomics”.
Experimental Biology, Washington DC. April 2011.
Invited talk: “Targeted Gene Disruption in Rats via Zinc Finger Nucleases”. Renal Hemodynamics:
Animal Models and Their Value in Predicting Efficacy and Toxicity Conference. New York.
September 2011.
Session Chair and organizer: “Featured Topic: ‘Hypertension:Mechanisms and Consequences”.
Experimental Biology, San Diego CA. April 2012.
Regional/Local
Departmental Seminar: "Regulation of intrarenal hemodynamics during increments in extracelular
volume". Medical College of Wisconsin, Milwaukee, Wisconsin. May 2000.
Invited talk: “Phenotyping for the analysis of genetic linkage”. Marquette University and
Bioinformatics Research Center, Medical College of Wisconsin. Milwaukee, Wisconsin. June 2002.
Departmental Seminar: "Salt-sensitive hypertension. Narrowing the distance to the genes". Medical
College of Wisconsin, Milwaukee, Wisconsin. May 2003.
Invited talk: “Integrative Tools for Gene Discovery”. General Clinical Research Center Genetic Series.
Medical College of Wisconsin, Milwaukee, Wisconsin. October 2006.
Invited talk: “Positional cloning for hypertension Genes”. Graduate School open house. Medical
College of Wisconsin, Milwaukee, Wisconsin. September 2009.
Invited talk: “Progress Report: Mapping modifier genes for ARPKD in the rat”. Research Center of
Excellence in Pediatric Nephrology. Medical College of Wisconsin, Milwaukee, Wisconsin. February
2010.
Invited talk: Children’s Research Institute Research Conference. Medical College of Wisconsin,
Milwaukee, Wisconsin. March 2010.
Departmental Seminar: " Tools for Dissecting the Genetic Determinants of Hypertension in the Rat".
Medical College of Wisconsin, Milwaukee, Wisconsin. February 2011.
Invited talk: “Progress Report: Mapping modifier genes for ARPKD in the rat”. Research Center of
Excellence in Pediatric Nephrology. Medical College of Wisconsin, Milwaukee, Wisconsin. March
2011.
Invited speaker: “Strategies for Success in Science: A Balancing Act”. Annual joint lunch with MCW
Women Faculty and Women Graduate Students. Medical College of Wisconsin, Milwaukee, Wisconsin.
May 2011.
8
COMMITTEE SERVICE
2005-2009
Faculty Career Development Committee. Medical College of Wisconsin.
2006-2007
Chair of Networking Subcommittee.
2007-2008
Chair of Faculty Career Development Committee.
2008-2010
Academic Skills Development subcommittee ad hoc member.
2008-2009
Faculty Affairs Self-Study Committee.
2009-2012
Academic Standing Committee. Medical College of Wisconsin.
2009-2012
IACUC Committee. Medical College of Wisconsin.
2009-2012
Physician Scientist Pathway Committee. Medical College of Wisconsin.
2009
Liaison with Industry Committee. Medical College of Wisconsin.
2010-2011
LCME Education Program Self-Study Subcommittee. Medical College of Wisconsin.
MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
2000–2001
Teaching Assistant, Department of Physiology,
Medical College of Wisconsin, Milwaukee, WI
(Renal Function Small Group Session)
2007–2009
Instructor, Cardiovascular pig lab, Department of Physiology,
Medical College of Wisconsin, Milwaukee, WI
2004-2009
Director of Seminar Course in Physiology
2009-2012
Lecturer. General Human Physiology-GI tract.
Graduate Student Education
1997–present
Tutor, Physiology, Pharmacology and Genetics
2003–2008
Physiological Genomics Course
EXTRAMURAL TEACHING (e.g. at Marquette, UWM, etc.):
1997-1999
Teaching Assistant, Department of Physiology,
Universidad de Murcia, Spain, (Cardiovascular and Gastrointestinal Physiology)
2005
Graduate Course. University of Murcia, Spain
MCW STUDENTS, FACULTY. RESIDENTS AND CLINICAL/RESEARCH FELLOWS
MENTORED:
9
Undergaduate Students
2003
Chris Janowak. SPUR
2004
Maggie Leverence. SPUR
2005
Michael Soule. SPUR
2011
Eleanor Christenson SPUR
Summer Student Mentor
Summer Student Mentor
Summer Student Mentor
Summer Student Mentor
Medical Students
2004
2007
2007
2009
MSRTP Student Mentor
MSRTP Student Mentor
Mentor. Research Thesis for Honors in Research.
MSRTP Student Mentor
Barbara Meinecke.
Erin Mathewson.
Barbara Meinecke.
Brennan Decker
Graduate Students
Ph.D./M.S. Committees
2007
Michael Harrison
2010
Mathew Durand
Dissertation Committee.
Dissertation Committee.
PROGRAMMATIC DEVELOPMENTS
Research Programs
2009 Development of Animal Management Database. Human and Molecular Genetics Center.
Medical College of Wisconsin.
Community Programs
2008 Development of Faculty Collaboration Database. Medical College of Wisconsin.
COMMUNITY SERVICE ACTIVITIES:
2004-2008
La Causa Amigos, Fund-Raising Comittee.
2004
United Way Fund-Raising Campaign Volunteer Representative, Department of
Physiology, Medical College of Wisconsin
2005
SPUR evaluation committee. Medical College of Wisconsin
2005-2007
World Congress of Microcirculation organizing committee.
2006
Croatian Symposium of Hypertension. Scientific Board.
2007
Guest Speaker. La Causa Charter School Career Fair.
2011
Judge. Milwaukee Schools Science Fair.
BIBLIOGRAPHY
Original Papers:
10
1.
E. Nava, A. López-Farré, C. Moreno, S. Casado, P. Moreau, F. Consentino and T.F. Luscher.
Alterations to the nitric oxide pathway in the spontaneously hypertensive rat. Journal of
Hypertension 16: 609-615, 1998.
2.
M.T. Llinás, J.D. González, C. Moreno and F.J. Salazar. Interacción entre óxido nítrico y
prostaglandinas en el control de la función renal. Hipertensión, 15:44-52, 1998.
3.
E. Nava, A.L. Farré, C. Moreno, S. Casado, P. Moreau, F. Consentino and T.F. Luscher.
Alteraciones de la vía del óxido nítrico en la rata espontáneamente hipertensa. Iberoamerican
Journal of Hypertension, 3: 385-391, 1998.
4.
S.Y. Chin, K.N. Pandey, S.J. Shi, H. Kobori, C. Moreno, and L. Gabriel Navar. Increased
activity and expression of calcium-dependent nitric oxide synthases in renal cortex of
angiotensin II-infused hypertensive rats. American Journal of Physiology 277:F797-F804, 1999.
5.
J.D. González, M.T. Llinás, C. Moreno, F. Rodríguez and F.J. Salazar. Renal effects of
prolonged cyclooxygenase inhibition when angiotensin II levels are elevated. Journal of
Cardiovascular Pharmacology, 36:236-41, 2000
6.
M.T. Llinas, F. Rodriguez, C. Moreno and F.J. Salazar. Role of cyclooxygenase-2 derived
metabolites and nitric oxide in regulating renal function. American Journal of Physiology,
279:R1641-R1646, 2000.
7.
E. Nava, F. Rodríguez, C. Moreno and F.J.Salazar. Release of nitric oxide following acute
pharmacological hypertension. Journal of Cardiovacular Pharmacology. 36(4):444-450, 2000.
8.
F. Rodríguez, M.T. Llinás, C. Moreno and F.J. Salazar. Role of cyclooxygenase-2 derived
metabolites and nitric oxide in the renal response to bradykinin. Hypertension, 37:129-134,
2001.
9.
C. Moreno, K. Maier, K. Hoagland, M. Yu and R.J. Roman. Abnormal Pressure-Natriuresis in
Hypertension: role of Cytochrome P450 metabolites of Arachidonic Acid. American Journal of
Hypertension. 14:90S-97S, 2001.
10.
B. Lopez, C. Moreno, M.G. Salom, R.J. Roman and F.J. Fenoy. Role of Guanylyl cyclase and
Cytochrome P450 on the renal response to nitric oxide. American Journal of Physiology Renal
Physiology 281: F420-427, 2001.
11.
K.M. Hoagland, K.G. Maier, C. Moreno, M.Yu, R.J. Roman. Cytochrome P450 metabolites of
arachidonic acid: novel regulators of renal function. Nephrol Dial Transplant. 16:2283-2285.
2001.
12.
C. Moreno, A. Lopez, M.T. Llinas, F. Rodríguez, A. Lopez-Farre, E. Nava, F.J. Salazar.
Changes in NOS activity and protein expresión during acute and prolonged ANG II
administration. American Journal of Physiology Regul Integr Comp Physiol 282:R31-R37, 2002.
11
13.
C. Moreno, M. Mistry and R.J. Roman. Renal effects of Glucagon-like peptide in rats. European
Journal of Pharmacology. 434:163-167, 2002.
14.
M. Szentivanyi Jr., A.P. Zou, D.L. Mattson, P. Soares, C. Moreno, R.J. Roman, A.W. Cowley
Jr. Renal medulary nitric oxide deficit of Dahl S rats enhances hypertensive actions of
angiotensin II. American Journal of Physiology Regul Integr Comp Physiol 286:R266-R272,
2002.
15.
F. Kehl, H. Shen, C. Moreno, N.E. Farber, R.J. Roman, J.P. Kampine, A.G. Hudetz. Isofluraneinduced cerebral hyperemia is partially mediated by nitric oxide and epoxyeicosatrienioc acids in
mice in vivo. Anesthesiology 97:1528-1533, 2002.
16.
M. Yu, C. Moreno, K.M. Hoagland, A. Dahly, K. Ditter, M. Mistry, R.J. Roman.
Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats. Journal of
Hypertension 21:1125-1135, 2003.
17.
C. Moreno, P. Dumas, M.L. Kaldunski, P.J. Tonellato, A.S. Greene, R.J. Roman, Q. Cheng, Z.
Wang, H.J. Jacob, A.W. Cowley Jr. Genomic map of cardiovascular phenotypes of hypertension
in female Dahl S rats. Physiological Genomics. Physiological Genomics 15(3):243-57, 2003.
18.
C. Moreno, D. Pollock. Understanding renal and cardiovascular function through physiological
genomics. Physiological Genomics 16: 178-179, 2004.
19.
A. Rangel-Filho, M. Sharma, Y.H. Datta, C. Moreno, R.J. Roman, Y. Iwamoto, A.P. Provoost,
J. Lazar, H.J. Jacob. Rf-2 Gene Modulates Proteinuria and Albuminuria Independently of
Changes in Glomerular Permeability in the Fawn-Hooded Hypertensive Rat. Journal of the
American Society of Nephrology 16: 852-856, 2005.
20
J. Lazar, C. Moreno, H.J. Jacob, A.E. Kwitek. Impact of Genomics on Research in the Rat.
Genome Research 15: 1717-1728, 2005.
21.
B. López, R.P. Ryan, C. Moreno, A. Sarkis, J. Lazar, A.P. Provoost, H. J. Jacob, R.J. Roman.
Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in Fawn HoodedHypertensive rats. American Journal of Renal Physiology 22, 2006.
22.
X. Wang, S. Jia, L. Meyer, B. Xiang, L.Y. Chen, N. Jiang, C. Moreno, H.J. Jacob, S. Ghosh and
M.J. Hessner. Comprehensive quality control utilizing the prehybridization third-dye image leads
to accurate gene expression measurements by cDNA microarrays. BMC Bioinformatics 14:
7:378, 2006.
24.
C. Moreno , M.L. Kaldunski, T. Wang, R.J. Roman , A.S. Greene, J. Lazar, H.J. Jacob, A.W.
Cowley Jr. Multiple Blood Pressure loci on rat Chromosome 13 attenuate the development of
hypertension in the Dahl S Hypertensive rat. Physiological Genomics. Oct 22;31(2):228-35,
2007.
12
25.
M.M. de Resende, S.L. Amaral, C. Moreno, A.S. Greene. Congenic strains reveal the effect of
the renin gene on skeletal muscle angiogenesis induced by electrical stimulation. Physiological
Genomics. Mar 14;33(1):33-40. 2008.
26.
C. Moreno, J. Lazar, H.J. Jacob, A.E. Kwitek. Comparative Genomics for Detecting Human
Disease Genes. Adv Genet.;60:655-97, 2008.
27.
T. Aitman, J. K. Critser, E. Cuppen, A. Dominiczak, X. M. Fernandez, J. Flint, D. Gauguier, A.
M. Geurts, M. Gould, P. C. Harris, R. Holmdahl, N. Hubner, Z. Izsvak, H. J. Jacob, T.
Kuramoto, A. E. Kwitek, A. Marrone, T. Mashimo, C. Moreno, J. Mullins, L. Mullins, T.
Olsson, L. Riley, K. Saar, T. Serikawa, J. D Shull, C. Szpirer, S. N. Twigger, B. Voigt, K.
Worley. Progress and prospects in rat genetics. Nature Genetics. May;40(5):516-22, 2008.
28.
J.M. Williams, A. Sarkis, K.M. Hoagland, K. Fredrich, R.P. Ryan, C. Moreno, B. Lopez, J.
Lazar, F.J. Fenoy, M. Sharma, M.R. Garrett, H.J. Jacob, R.J. Roman. Transfer of the CYP4A
region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. Am J Physiol Renal
Physiol. Dec;295(6):F1764-77, 2008.
29.
M. Bilusic, C. Moreno, N. E. Barreto, M.R. Tschannen, E.L. Harris, W.K. Porteous, C.M.
Thompson, M.R. Grigor, A. Weder, E. Boerwinkle, S.C. Hunt, J.D. Curb, H.J. Jacob, A.E.
Kwitek. Genetically Hypertensive Brown Norway congenic rat strains suggest intermediate traits
underlying genetic hypertension. Croat Med J. Oct;49(5):586-99, 2008.
30.
I. Drenjancevic-Peric, M. Durand, C. Moreno, JH. Lombard. Dilations of middle cerebral
arteries of salt-sensitive rats are restored by receiving portions of Brown Norway chromosome 13
containing the BN renin allele. Proceedings of the 25th European Society for Microcirculation
Meeting. 51-56. 2008.
31.
A. Stadnicka, S.J. Contney, C. Moreno, D. Weihrauch, Z.J. Bosnjak, R.J. Roman, T.A. Stekiel.
Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive (SS), Brown
Norway (BN) and chromosome 13 substituted consomic rat strains: role of large conductance
Ca2+ and voltage activated potassium (BK) channels. J Pharmacol Exp Ther. 2009.
32.
L.Lu, P. Li, C. Yang, T. Kurth, M. Misale, M. Skelton, C. Moreno, R.J. Roman, A.S. Greene,
H.J. Jacob, J. Lazar, M. Liang, A.W. Cowley, Jr. Dynamic convergence and divergence of renal
genomic and biological pathways in protection from Dahl salt-sensitive hypertension.
Physiological Genomics. 2010 Mar 3;41(1):63-70.
33.
H. Shao, D.S. Sinasac, L.C. Burrage, C.A. Hodges, P.J. Supelak, M.R. Palmert, C. Moreno,
A.W. Cowley Jr, H.J. Jacob. J.H. Nadeau. Analyzing complex traits with congenic strains.
Mammalian Genome. 2010 June; 21(5-6):276-86.
34.
A.M.Geurts, C.Moreno. Zinc-finger nucleases: new strategies to target the rat genome. Clin Sci
(Lond). 2010 Jul 6;119(8):303-11.
35.
T.Adamovic, D.McAllister, T.Wang, D.Adamovic, J.J.Rowe, C. Moreno, J.Lazar, H.J.Jacob,
S.L.Sugg. Identification of Novel Carcinogen-mediated Mammary Tumor Susceptibility Loci in
13
the Rat Using the Chromosome Substitution Technique. Genes, Chromosomes and Cancer. 2010.
2010 Nov;49(11):1035-45.
36.
H.J.Jacob, J.Lazar, M.R.Dwinell, C.Moreno, A.M.Geurts. Gene targeting in the rat: advances
and opportunities. Trends Genet. 2010 Dec;26(12):510-8.
37.
M.J.Durand, C.Moreno, A.S.Greene, J.H.Lombard. Impaired relaxation of cerebral arteries in
the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive
renin gene. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74.
38.
C.C.O'Meara, J.Lazar, M.Hoffman, C.Moreno, J.H.Jacob HJ. Refined Mapping of the Renal
Failure Rf-3 Quantitative Trait Locus. J Am Soc Nephrol. 2011. Mar;22(3):518-25..
39.
C.Moreno, M.Hoffman,T.J.Stodola, D.N.Didier, J.Lazar, A.M.Geurts, P.E.North, H.J.Jacob,
A.S.Greene. Creation and characterization of a renin knock out rat. Hypertension. 2011
Mar;57(3):614-9.
40.
C.Moreno , J.M.Williams, L.Lu, M. Liang, J.Lazar , H.J.Jacob, A.W.Cowley Jr, R.J.Roman.
Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN
congenic strains. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5.
41.
Q.Wang, J.Chow, J.Hong, A.F.Smith, C.Moreno, P.Seaby, P.Vrana, K.Miri, J.Tak, E.Chung,
G.Mastromonaco, I.Cannigia, S.Varmuza. Recent acquisition of imprinting at the rodent Sfmbt2
locus correlates with insertion of a large block of miRNAs. BMC Genomics. 2011 Apr
21;12(1):204.
42.
T.J.Stodola, M.M.de Resende, A.Sarkis, D.N.Didier, H.J.Jacob, N.Huebner, O.Hummel, K.Saar,
C.Moreno, A.S.Greene. Characterization of the genomic structure and function of regions
influencing renin and angiogenesis in the SS rat. Physiol Genomics. 2011 Apr 26. In press.
Book Chapters:
1.
E. Nava, C. Moreno, and F.J. Salazar. Increased constitutive nitric oxide synthase activity in the
aged heart. Effects of hypertension. In: The biology of nitric oxide. Part 7. Eds: S. Moncada, E.A.
Higgs, P.Wilkind and L. Gustansson. Portland Press, London. 2001.
2.
C. Moreno, K. Kennedy, J.W. Andrae, H.J. Jacob. Genome wide scanning with SSLPs in the
rat. In: Humana Press, Molecular Methods in Hypertension. J. Fennell and A.H. Baker (editors).
2004.
3.
C. Moreno, H.J. Jacob. Integrating Biology with Rat Genomic Tools. In: Academic Press. The
Laboratory rat. M. Suckow (editor). 2005.
4.
C. Moreno, H.J. Jacob, A.W. Cowley Jr. Attaching physiology to the genome. In: Handbook of
Hypertension, Genetics of Hypertension. Anna Dominikzac (editor). Elsevier. 2007.
14
5.
C. Moreno, J. Lazar, H.J. Jacob, A.E. Kwitek. Comparative Genomics for Detecting Human
Disease Genes. In: Genetic Dissection of Complex Traits. D.C. Rao (editor). Elsevier. Adv
Genet.;60:655-97. 2008.
ABSTRACTS
1.
C.Moreno, E.López, J.L.Tornel, M.G.Salóm, F.J.Fenoy. “Efectos de la Nw-nitro-L-arginina y Nacetil-L-cisteína sobre la reversión de la hipertensión 1-riñón, 1-clip.” 1ª Reunión Nacional.
Sociedad Española de Hipertensión, Liga Española para la lucha contra la Hipertensión Arterial.
Hipertensión, Volumen 13. 1996.
2.
M.T.Llinás, J.D. González, E.Nava, C.Moreno, F.J.Salazar. “Role of prostaglandins in the longterm renal effects of angiotensin II.” 1st International Joint Meeting of Physiology. 1997
3.
F.Rodríguez, E.Nava, C.Moreno, M.T.Llinás, F.J.Salazar. “Nitric oxide release during the
intrarrenal infusion of bradikinin.” International Joint Meeting of Physiology. 1997.
4.
E.Nava, F.J.Salazar, F.Rodríguez, J.D.González, C.Moreno. “Changes in nitric oxide release in
vivo in response to vasoactive substances.” International Joint Meeting of Physiology. 1997.
5.
M.T.Llinás, J.D.González, E.Nava, C.Moreno, F.J.Salazar. “Papel de la prostaglandinas en los
efectos renales a largo plazo de la angiotensina II.” 2ª Reunión nacional Sociedad Española de
Hipertensión, Liga Española para la lucha contra la Hipertensión Arterial. 1997.
6.
J.D.González, M.T.Llinás, F.Rodríguez, C.Moreno, F.J.Salazar. “Role of prostaglandins in the
regulation of the renal effects induced by prolonged increments of angiotensin II.” Experimental
Biology. 1998.
7.
J.D.González, M.T.Llinás, C.Moreno, T.Quesada, F.J.Salazar. “Efectos del trandolapril y
verapamil en los cambios de función renal inducidos por el descenso de NO y PG.” 3ª Reunión
Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión
Arterial. 1998.
8.
C.Moreno, F.Rodríguez, M.T.Llinás, J.D.González, F.J.Salazar. “Flujo sanguíneo medular renal
en la regulación del volumen extracelular. Importancia del NO y PG.” 3ª Reunión Nacional.
Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial.
1998.
9.
E.Nava, F.Rodríguez, C.Moreno, F.J.Salazar. “Producción de óxido nítrico en respuesta a
hipertensión farmacológica aguda.” 3ª Reunión Nacional. Sociedad Española de Hipertensión.
Liga Española para la lucha contra la Hipertensión Arterial. 1998.
10.
M.T.Llinás, F.Rodríguez, C.Moreno, E.Nava, F.J.Salazar. “Role of cyclooxygenase 2 and nitric
oxide in mediating the bradykinin renal effects.” Experimental Biology. 1999.
11.
F.J.Salazar, M.T.Llinás, J.D.González, F.Rodríguez, C.Moreno. “Chronic NOS inhibition and
renal function.” 2nd FEPS congress. 1999.
15
12.
C.Moreno, E.Nava, J.D.González, T.Quesada, F.J.Salazar. “Actividad tisular de la NO sintasa
en la respuesta a aumentos agudos y crónicos de angiotensina II.” 4 ª Reunión Nacional.
Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial.
1999.
13.
F.Rodríguez, M.T.Llinás, J.D.González, C.Moreno, F.J.Salazar. “Efectos renales de la
inhibición de la ciclooxigenasa 2 durante una ingesta de sodio normal o baja.” 4ª Reunión
Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión
Arterial. 1999.
14.
C.Moreno, E.Nava, M.T.Llinás, F.Rodríguez, A.López-Farré, F.J.Salazar. “Changes in nitric
oxide synthase activity during acute and prolonged increments in angiotensin II.” Experimental
Biology. 2000.
15.
M.T.Llinás, F.Rodríguez, C.Moreno, F.J.Salazar. “Cyclooxygenase-derived metabolites and
nitric oxide in regulating renal function.” Experimental Biology. 2000.
16.
B.López, C.Moreno, F.Valero, M.García Salom, F.J.Fenoy. “Acciones renales del óxido nítrico
independientes de la activación de la guanilato ciclasa.” 5ª Reunión Nacional. Sociedad Española
de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2000.
17.
M.T.Llinás, F.Rodríguez, C.Moreno, F.J.Salazar. “Importancia de los metabolitos de la COX-2
y del óxido nítrico en la regulación de la función renal.” 5ª Reunión Nacional. Sociedad Española
de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2000.
18.
K.G.Maier, M.R.Taheri, C.Moreno, R.J.Roman. “Regulation of CYP450A activity by Nitric
Oxide.” Experimental Biology 2001.
19.
C.Moreno, F.J.Fenoy, K.M.Hoagland, K.G.Maier, M.R.Garret, J.P.Rapp, R.J.Roman.
“Transferring the CYP4A region of chromosome 5 reduces glomerular capillary pressure and
glomerular injury in congenic Dahl Rats.” Experimental Biology 2001.
20.
C.Moreno, P.Dumas, M.Stoll, A.S.Greene, M.L.Kaldunski, R.J.Roman, P.J.Tonellato, Z.Wang,
H.J.Jacob, A.W.Cowley. “Gender differences in the genetic determinants of hypertension”.
Council for High Blood Pressure Reseach. September 2002.
21.
C.Moreno, R.P.Ryan, S.Jene, K.Kennedy, J.V.Eckert, H.J.Jacob, A.P.Provoost, R.J.Roman.
“Impaired autoregulation of renal blood flow is linked to the Rf-1 region in the Fawn-hooded
rat”. American Society of Nephrology. October 2002.
22.
C.Moreno, G.M.Tadisch, B.J.Meinecke, M.L.Kaldunski, H.J.Jacob, A.W.Cowley. “Genetics of
Salt-Sensitive Hypertension. Genetic linkage and Congenic Development from the Consomic
SS.BN.13 Rat”. APS Conference: Understanding Renal and Cardiovascular Function Through
Physiological Genomics. October 2003.
16
23.
C.Moreno, S.Khan, N.Jiang, J.Lazar, M.Tschannen, M.Jensen-Seaman, J. Tackes, S. Jene, M.
Hessner, HJ. Jacob “Microarray analysis of gene expression changes in the kidney of the Rf-1
congenic strain of the Fawn-Hooded rat”. Rat genetics Symposium. Cold Spring Harbor.
December 2003.
24.
B.Lopez, C.Moreno, R.Ryan, S. Jene, K.Kennedy, J.Eckert, H.J.Jacob, A.P.Provoost,
R.J.Roman. “La region Rf-1 del cromosoma 1 contribuye al desarrollo de la enfermedad
glomerular en las ratas Fawn-Hooded”. 9ª Reunión Nacional. Sociedad Española de
Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2004.
25.
C.Moreno, S.Khan, N.Jiang, M.Jensen-Seaman, J.Lazar, A.Provoost, M.J.Hessner, H.J.Jacob.
“Patron temporal de expresión genetica en el rinon de la rata congenica ACI.FHH.RF-1”. 9ª
Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la
Hipertensión Arterial. 2004.
26.
C.Moreno, M.L.Kaldunski, J.Lazar, R.J.Roman, A.S.Greene, H.J.Jacob, A.W.Cowley.
“Identificación de un locus de hipertensión sal-sensible mediante el uso de lincage genetico en
ratas consomicas”. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para
la lucha contra la Hipertensión Arterial. 2004.
27.
C.Moreno, P.Khampang, D.Schippers, J.Lazar, M.L.Kaldunski, A.S.Greene, R.J.Roman,
H.J.Jacob, A.W.Cowley. “Expresión renal y secuencia comparativa de la ciclooxigenasa-2 en
hipertensión sal-sensible”. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga
Española para la lucha contra la Hipertensión Arterial. 2004.
28.
B.López, A.Sarkis, N.Wenberg, E. Santos, C.Moreno and R.J.Roman.. “Efectos de los
inhibidores del citocromo P450 y de un antagonista del 20-HETE sobre la funcion renal en
ratas”. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha
contra la Hipertensión Arterial. 2004.
29.
C.Moreno, P.Khampang, D.Schippers, J.Lazar, M.L.Kaldunski, A.S.Greene, R.J.Roman,
A.E.Kwitek, H.J.Jacob, A.W.Cowley. “Renal expression and sequence comparison of
cyclooxygenase 2 in salt-sensitive hypertension”. Experimental Biology 2004.
30.
B.Lopez, R.P.Ryan, C.Moreno, J.Lazar, H.J.Jacob, A.P.Provoost and R.J.Roman. “Identification
of a QTL on region of chromosome 1 for impaired autoregulation of RBF in Fawn-Hooded
Hypertensive rats”. Council of High Blood Pressure Research. September 2004.
31.
X.Wang, S.Jia, N.Jiang, M.Chen, L.Meyer, C. Moreno, H.J.Jacob, S.Ghosh and M.J.Hessner.
“MCW microarray QC platform: a pathway to quantitative and sensitive gene expression
profiling”. 7th International Meeting of the Microarray Gene Expression Data Society. Toronto,
2004.
32.
B.Meinecke, H.J.Jacob, C.Moreno. “Role of Cyclooxygenase 2 in the development of saltsensitive hypertension”. MCW Medical Student Poster Session, 2004.
17
33.
C.Moreno, S.Khan, N.Jiang, J.Lazar, M.Tschannen, M.I.Jensen-Seaman, A.Provoost,
M.J.Hessner, H.J.Jacob. “Temporal patterns of gene expression in the kidney of the Rf-1
congenic rat strain”. American Society of Nephrology. October 2004.
34.
M.Sharma, J.Lazar, M.Lutz, N.Barreto, J.W.Andrae, C.Moreno, S.van Dijk, A.P.Provoost,
E.T.McCarthy, V.J.Savin, H.J.Jacob “In Vitro Glomerular Albumin Permeability (Palb) as an
Early Phenotypic Marker of Renal Injury”. American Society of Nephrology. October 2004.
35.
M.M.Lutz, J.W.Andrae, M.Sharma, J.Lazar, C.Moreno, A.P.Provoost, H.J.Jacob. “Focusing in
on Rf-4: The Use of Subcongenic Rat Strains To Narrow the Region of CHR. 14 Involved in
Hypertensive Renal Failure”. American Society of Nephrology. October 2004.
36.
K.P.Strohl, C.Moreno, J.Lazar, M.Tschannen, B.Erokwu, T.Feroah, H.J.Jacob. “A GenomeWide Scan for Respiratory Frequency in Male Rats”. American Thoracic Society, 2004.
37.
C.Moreno, M.Tschannen, M.Chen, J.Lazar,Jr., S.Khan, N.Jiang, M.J.Hessner, A. Provoost, J.
Lazar and H.J. Jacob. Early detection of markers of end-stage renal disease in the fawn-hooded
hypertensive rat. Experimental Biology. April 2005.
38.
M.M.Lutz, J.Lazar, M.Sharma, C.Moreno, J.Wendt Andrae, A.P.Provoost and H.J.Jacob.
Narrowing Rf-4, a locus on rat chromosome 14 linked to hypertension-induced renal failure.
Experimental Biology. April 2005.
39.
C.Moreno, M.L.Kaldunski, R.J.Roman, A.S.Greene, J.Lazar, A.W.Cowley,Jr and H.J. Jacob.
Overlapping Congenics for the dissection of the genetic determinants of blood pressure. The
Biology of the Genomes. Cold Spring Harbor. May 2005.
40.
A.Sarkis, B.Lopez, K.M.Hoagland, C.Moreno, F.J.Fenoy, J.Lazar, H.J.Jacob, A.E.Kwitek,
M.R.Garrett, J.P.Rapp and R.J.Roman. Transfer of the CYP4A region from Lewis rats into Dahl
S background reduces renal injury. Council of High Blood Pressure Research. October 2005.
41.
R.R.Majewski, J.Lazar, M.Hessner, C.Moreno, A.E.Kwitek, J.Jurinic, A.Lemke, J.WendtAndrae and H.J. Jacob. High-throughput production of rat knockout models for hypertension
using ENU mutagenesis and tilling assay. Rat Genomics and Models Symposium. Cold Spring
Harbor. December 2005.
42.
C.Moreno, J.W.Andrae, M.Lutz, K.Orlebeke, J.Lazar, A.S.Greene, S.N.Twigger and H.J. Jacob.
Concordance of allele characterization project data with SNP distribution across rat strains. Rat
Genomics and Models Symposium. Cold Spring Harbor. December 2005.
43.
K.P.Strohl, C.Moreno, J.Lazar, M.Tschannen, B.Erokwu and H.J.Jacob. A genome scan for
breathing frequency in Sprague Dawley and Brown Norway rats. Rat Genomics and Models
Symposium. Cold Spring Harbor. December 2005.
44.
M.MLutz, J.Lazar, M.Sharma, C.Moreno, J.W.Andrae, A.P.Provoost and H.J.Jacob. Sequence
and gene expression comparison in a narrowed region of RF-4 locus in ACI, FHH and double
congenic rats. Rat Genomics and Models Symposium. Cold Spring Harbor. December 2005.
18
45.
C.Moreno, M.L.Kaldunski, T.Wang, J.Lazar, R.J.Roman, A.S.Greene, H.J.Jacob and
A.W.Cowley Jr. Existence of Multiple Blood Pressure loci on Rat Chromosome 13 of the Dahl S
Hypertensive Rat. Experimental Biology. April 2006.
46.
C.Moreno, M.L.Kaldunski, T.Wang, R.J.Roman, A.S.Greene, J.Lazar, H.J.Jacob and
A.W.Cowley Jr. Existence of multiple blood pressure loci on rat chromosome 13 of the Dahl S
hypertensive rat. European Meeting on Hypertension. Madrid, June 2006.
47.
C.Moreno, R.Rogge, M.L.Kaldunski, B.Lopez, J.Lazar, A.W.Cowley Jr and H.J.Jacob.
Characterization of blood pressure and protein excretion in chromosome 18 congenic strains of
Dahl S rats. Council of High Blood Pressure Research. San Antonio, AZ. October 2006.
48.
C.Moreno. Dissecting the genetic architecture of salt-sensitive hypertension. First International
Symposium on Hypertension: From Laboratory Bench to Clinical Settings, from 25.-28. Osijek,
Croatia August 2006.
49.
C.Moreno, R.Rogge, J.Lazar, M.Tschannen, M.L.Kaldusnki, A.W.Cowley Jr and H.J.Jacob.
Characterization of blood pressure and protein excretion in chromosome 18 congenic strains of
Dahl S rats. Rat Genome & Models Meeting. Melbourne. Australia. December 2006.
50.
C.Moreno, M.Shimoyama, J.Chen, G.Kowalski, S.Laulederkind, D.Li, R.Nigam, A.Patzer,
V.Petri, J.Smith, S.Twigger, A.E.Kwitek, H.J.Jacob. The Rat Genome Database: Integrated Data
Platform. EURATools Annual Mtg. Prague, Czech Republic. February 2007.
51.
H.J.Jacob, J.Lazar, A.Rangel, M.Lutz, M.Sharma, S.J.Van Dijk, R.J.Roman, C.Moreno and
A.P.Provoost. Genetic complexity of hypertension associated renal failure. Forefronts
Symposium on Nephrogenetics. Danvers, MA. March 2007.
52.
C.Moreno, M.R.Dwinell, R.Majewski, A.E.Kwitek, M.J.Hessner, T.R.Feroah, H.V.Forster,
D.L.Mattson, J.H.Lombard, G.D.Mcquestion, R.J.Roman, A.S.Greene, A.W.Cowley and
H.J.Jacob. High-Throughput Production and Phenotyping of Rat Knockout Models for
Hypertension. Experimental Biology. Washington, April 2007.
53.
M.M. Resende, S.L. Amaral, C.Moreno and A.S.Greene. Congenic strains reveal the effect of
the renin gene on skeletal muscle angiogenesis induced by electrical stimulation. World Congress
of Microcirculation. Milwaukee, WI, August 2007.
54.
J.H.Lombard, M.Durand and C.Moreno Reduced Expression of CopperZinc Superoxide
Dismutase (Cu/Zn SOD) in Cerebral Resistance Arteries of Dahl Salt Sensitive Rats vs.
SS.13BN controls and congenic rats carrying the BN renin gene. 61st Annual High Blood
Pressure Research Conference. Tucson, AZ, September 2007.
55
T. R.Feroah, H.V.Forster, A.Merritt, M.Dwinell, C.Moreno, A.Greene, H.Jacob and A.Cowley
Jr. Significant differences in novel and adapted circadian movement behavior in three parental
and two ENU knockout inbred strains of rats. Clinical Cardiovascular Genomics. Cold Spring
Harbor, NY. September 2007.
19
56.
C.Moreno, M.R.Dwinell, R.R.Schilling, A.E.Kwitek, A.S.Greene, R.J.Roman, T.R.Feroah,
H.V.Forster, D.L.Mattson, J.H. Lombard, G.D. McQuestion, A.W.Cowley and H.J.Jacob.
Production and characterization of rat knockout models for studying cardiovascular disease.
Clinical Cardiovascular Genomics. Cold Spring Harbor, NY. September 2007.
57.
C.Moreno, M.R.Dwinell, R.R.Schilling, A.E.Kwitek, A.S.Greene, R.J.Roman, J.Lazar,
D.L.Mattson, Julian J.H. Lombard, G.D. McQuestion, A.W.Cowley and H.J.Jacob. Modeling
cardiovascular disease in rat by ENU mutagenesis. 21st International Mammalian Genome
Conference. Kyoto, Japan. October 2007.
58.
R.R.Schilling, J.Lazar, M.Hessner, C.Moreno, M.Dwinell, A.Lemke, J.Wendt-Andrae and
H.J.Jacob. High-throughput production of rat knockout models for hypertension using ENU
mutagenesis and tilling assay. Rat Genomics and Models. Cold Spring Harbor, NY, December
2007.
59.
J.Lazar, A.Stadnicka, C.Moreno, Z.Bosnjak M. and H.J.Jacob. Functional cardiac abnormalities
in animal models with Type 2 Diabetes Mellitus. Rat Genomics and Models. Cold Spring
Harbor, NY, December 2007.
60.
C.Moreno, M.Durand, M.M.Resende, M.L. Kaldunski, J.Lazar, J.Lombard, A.S.Greene,
A.W.Cowley Jr. and H.J.Jacob. Pleiotropic effects of the renin loci. Rat Genomics and Models.
Cold Spring Harbor, NY, December 2007.
61.
C.O’Meara, J.Lazar, C.Moreno, M.Tschannen, A.P.Provoost and H.J.Jacob. Investigating a
triple congenics rat model to determine genes contributing to renal failure. Cold Spring Harbor,
NY, December 2007.
62.
M.J.Durand, C.Moreno, J.J.Lombard. Restoration of Vascular Relaxation in Cerebral Arteries of
Congenic Dahl Rats Receiving the Brown Norway (BN) Renin Gene. The FASEB Journal.
2008;22:1142.5. Experimental Biology, San Diego, April 2008.
63.
A.Geurts, A.Lemke, C.Moreno, M.Dwinell and H.Jacob. PhysGen meets Sleeping Beauty – a
match made in rat heaven. International Society of Hypertension. Berlin, June 2008.
64.
PhysGen meets Sleeping Beauty – a match made in rat heaven. A. Geurts et al.. The Sixth
Annual International Conference on Transposition and Animal Biotechnology. Berlin, June 2008.
65.
C.Moreno, K.Brown, J.Kotchen, M.Eapen, G.Lamb, L.Meurer, T.Sander, J.Seagard,
T.Frederick, A.David and D.Simpson. Institutionalizing Faculty Career Development Through
the Faculty Governance Structure. AAMC Faculty Affairs Professional Development
Conference. Pittspurg, August 2008.
66.
R.J.Roman, C.Moreno, J.Lazar, A.W.Cowley Jr. and H.J.Jacob. Narrowing of a region on rat
chromosome 13 that protects against the development of hypertension using overlapping Dahl
SS.13BN congenic strains. Council of High Blood Pressure, Atlanta, September 2008.
20
67.
Mitchel et al. Chromosomal Substitution Strains Demonstrate that Patent Ductus Arteriosus is
Polygenic. American Heart Association. 2008.
68.
C.Moreno, W.E.Sweeney, J.Lazar, H.J.Jacob and E.D.Avner. Development of a rat model of
ARPKD to study genetic modifier loci. American Society of Nephrology. Philadelphia,
November 2008.
69.
M.Gros, J.Lazar, C.Moreno, H.J.Jacob and J.H.Lombard. Role of mitochondrial genome in
modulationg hypoxic dilation in cerebral arteries of animal models with type 2 diabetes mellitus.
Rat Genomics and Models. Hixton, UK. December 2008.
70.
C.Moreno, C.O’Meara, W.E.Sweeney, J.Lazar, E.D.Avner and H.J.Jacob. Towards mapping
modifier loci for ARPKD. Rat Genomics and Models. Hixton, UK. December 2008.
71.
C.O’Meara, J.Lazar, C.Moreno, A.P.Provoost and H.J.Jacob. The contribution of the Rf-3 QTL
in the development of renal failure. Rat Genomics and Models. Hixton, UK. December 2008.
72.
C.O’Meara, J.Lazar, C.Moreno, A.P.Provoost and H.J.Jacob. The Contribution of Genes on
Chromosome 3 to Renal Failure in the Fawn Hooded Hypertensive Rat. Experimental Biology,
New Orleans, April 2009.
73.
C. Moreno, R.Rogge, M.Tschannen, N.Barreto, J.Lazar, H.J.Jacob. Multiple Blood Pressure loci
on rat Chromosome 18 attenuate the development of hypertension in the Dahl S Hypertensive rat.
Experimental Biology, New Orleans, April 2009.
74.
L.Lu, P. Li, C.Yang, T.Kurth, M.Misale, M.Skelton, C.Moreno, A.S.Greene, H.J.Jacob,
R.J.Roman, J.Lazar, M.Liang, A.W.Cowley, Jr. Dynamic utilization of biological pathways in
protection against salt-sensitive hypertension. Council of High Blood Pressure, Chicago,
September 2009.
75.
C.Moreno, A.Geurts, J.Foeckler, S.Kalloway, R.Schilling, J.Klotz, A.S.Greene, H.Weiler,
H.J.Jacob. Development of a Rat Knockout for the Renin Gene. Council of High Blood Pressure,
Chicago, September 2009.
76.
J.Lazar, D.Rai, C.Moreno, W.Sweeney, H.J.Jacob. Differencia effect of a Western Diet on GK
and T2DN Rats. Rat Genomics & models. Cold Spring Harbor, NY. December 2009.
77.
H. J.Jacob, A.Rangel-Filho, R.Schilling, A.Lemke, S.Kalloway, J.Foeckler, J.Klotz, H.Weiler
J.Lazar, C.Moreno, A.M. Geurts. Validation of rab38 using transgenic rescue and gene ko. Rat
Genomics and Models. Cold Spring Harbor, NY. December 2009.
78.
C.O’Meara, J.Lazar, C.Moreno and H.J.Jacob. Physiological genomics of the renal failure 3 (Rf3) quantitative trait locus. Rat Genomics and Models. Cold Spring Harbor, NY. December 2009.
79.
A.M. Geurts, R.Schilling, A.Lemke, S.Kalloway, J.Foeckler, J.Klotz, H.Wiler, L.Worthey,
E.Ostertag, M.Dwinell, D.Mattson, J.Lombard, A.W.Cowley, C.Moreno, H.J.Jacob. The rat
21
knockout project: Unraveling complex human disease through advances in rat knockout
technology. Rat Genomics and Models. Cold Spring Harbor, NY. December 2009.
80.
K.P.Strohl, C. Moreno, J.Lazar, J.Dostal, M.Tschannen, B.Erokwu, H.J.Jacob. Linkage to posthypoxic ventilatory behavior in the rat. Rat Genomics and Models. Cold Spring Harbor, NY.
December 2009.
81.
C. Moreno, M.Hoffman, J.Lazar, J.H.Lombard, A.S.Greene, H.J.Jacob. Narrowing the blood
pressure loci around the renin gene. Rat Genomics and Models. Cold Spring Harbor, NY.
December 2009.
82.
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83.
A.Stadnicka, S.J.Contney, C.Moreno, R.J.Roman, T.A. Stekiel. Angiotensin II effects on BK
channel in mesenteric arterial smooth muscle cells of SS, BN and congenic renin+ and reninrats. Biophysical Society 54th annual meeting, San Francisco, CA, February 2010.
84. D.Feng, C.Yang, T.Kurth, M.Liang, C.Moreno, H.Jacob, A.W.Cowley, Jr. Renal Medullary
NAD(P)H-oxidase subunit p67ohox as a candidate gene in salt-sensitive hypertension.
Experimental Biology, Aneheim, April 2010.
85.
T.J.Stodola, M.Resende, C.Moreno, A.S.Greene. Restoration of angiogenesis phenotype in new
congenic lines based on Dahl Salt-Sensitive (SS/Mcwi) background. Experimental Biology,
Aneheim, April 2010.
86.
H. J.Jacob, A.M.Geurts, R.Schilling, A.Lemke, S.Kalloway, J.Foeckler, J.Klotz, H.Weiler,
J.Lazar, M.R.Dwinell, C.Moreno. From GWAS to function using sensitized strains, transgenic
rescue and gene KO. Genome Sequencing and Biology, Cold Spring Harbor, NY. May 2010.
87.
A.W.Cowley Jr., H.J.Jacob, C.Moreno, A.Greene, J.Lombard, D.Mattson, J.Lazar,
M.R.Dwinell, A.M.Geurts. Unraveling the genomic basis of hypertension: rat model systems.
International Congress of Pathophysiology, Montreal, Canada, September 2010.
88.
A.M.Geurts, R.Schilling, A.Lemke, M.Grzybowski, S.Kalloway, J.Foeckler, J.Klotz, H.Weiler,
J.Lazar, M.R.Dwinell, C.Moreno, H.J.Jacob. From genetics to function for human disease using
transgenic rescue and gene KO in sensitized rat strains. International Congress of
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J.Lazar, M.Dwinell, C.Moreno. GWAS to function for hypertension and renal disease using
transgenic rescue and gene KO. Council of High Blood Pressure, Washington, DC, October
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90.
C.Moreno, M.Hoffman, D.Didier, A.M.Geurts, J.Lazar, A.S.Greene, H.J.Jacob. Initial
characterization of the renin knockout rat. Council of High Blood Pressure, Washington, DC,
October 2010.
91.
T.A.Stekiel, J.B.McCallum, S.J.Contney, C.Moreno, A.G.Hudetz. Strain differences in
consciousness and EEG during induction and emergence using isoflurane. Anesthesiology 2010,
San Diego, CA, October 2010.
92.
J.Lazar, H.Xu, C.O’Meara, Z.Lazarova, C.Moreno, H.J.Jacob. Evaluation of SORCS1 as a
candidate gene for kidney failure. American Society of Nephrology, Denver, Co, November
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93.
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94.
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A.W.Cowley Jr., H.J.Jacob. Characterization of Nap5 KO rat for blood pressure and associated
phenotypes. Experimental Biology, Washington, April 2011.
95.
M.Hoffman, N.Barreto, P.Graff, J.Lazar, H.J.Jacob, C.Moreno. Narrowing of candidate region
on rat chromosome 18 responsible for attenuating the development of hypertension in the Dahl S
hypertensive rat. Experimental Biology, Washington, April 2011.
96.
T.Stodola, M.Hoffman, C.Moreno, A.S.Greene. Restoration of angiogenesis phenotype in new
congenic lines helps identify candidate genes for renin regulation in Dahl salt-sensitive
(SS/Mcwi) rats. Experimental Biology, Washington, April 2011.
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