1
HEP-05-1202
LIST OF PUBLICATIONS REVIEWED
S1. Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, et al. Derivation of hepatocytes
from bone marrow cells in mice after radiation-induced myoablation. Hepatology 2000; 31:235-240.
S2. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M., Osborne L, et al. Purified hematopoietic
stem cells can differentiate into hepatocytes in vivo. Nature Med 2000; 6:1229-1234.
S3. Gao Z, McAlister VC, Williams GM. Repopulation of liver endothelium by bone-marrow-derived cells.
Lancet 2001; 357:932-933.
S4. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, et al. Multi-organ, multilineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105:369-377.
S5. Mallet VO, Mitchell C, Mezy E, Fabre M , Guidotti J-E, Renia L, et al. Bone marrow transplantation in
mice leads to a minor population of hepatocytes that can be selectively amplified in vivo. Hepatology
2002; 35:799-804.
S6. Wang X, Montini E, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M. Kinetics of liver repopulation
after bone marrow transplantation. Am J Pathol 2002; 161:565-574.
S7. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of
adult hematopoietic stem cells. Science 2002; 297: 2256-2259.
S8. Fujii H, Hirose T, Oe S, Yasuchika K, Azuma H, Fujikawa M, et al. Contribution of bone marrow cells
to liver regeneration after partial hepatectomy in mice. J Hepatol 2002; 36:653-659.
S9. Wang X, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M. The origin and repopulating
capacity of murine oval cells. Proc Natl Acad Sci USA 2003; 100 (Suppl 1): 11881-11888.
S10. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, et al.
Pluripotency of mesenchymal stem cells derived from adult bone marrow. Nature 2002; 418:41-49.
S11. Kanazawa Y, Verma IM. Little evidence of bone marrow-derived hepatocytes in the replacement of
injured liver. Proc Natl Acad Sci USA 2003; 100 (Suppl 1):11850-11853.
2
S12. Wulf GG,Luo K, Jackson KA, Brenner MK, Goodell MA. Cells of the hepatic side population
contribute to liver regeneration and can be replenished by bone marrow stem cells. Haematologica 2003;
88:368-378.
S13. Abe S, Lauby G, Boyer L, Rennard SI, Sharp JG. Transplanted BM and BM side population cells
contribute progeny to the lung and liver in irradiated mice. Cytotherapy 2003; 5:523-533.
S14. Wang X, Willenberg H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, et al. Cell fusion is the
principal source of bone-marrow-derived hepatocytes. Nature 2003; 422:897-901.
S15. Vassilopoulos G, Wang P, Russell, DW. Transplanted bone marrow regenerates liver by cell fusion.
Nature 2003; 422:901-904.
S16. Alvarez-Dolado M, Pardai R, Garcia-Verdugo JM, Fike JR, Lee HO, Pfeffer K, et al. Fusion of bonemarrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003; 425:968-973.
S17. Camargo FD, Finegold M, Goodell MA. Hematopoietic myelomonocytic cells are the major source of
hepatocyte fusion partners. J Clin Invest 2004; 113:1266-1271.
S18. Jang Y, Collector MI, Baylin SB, Diehl AM, Sharkis, S. Hematopoietic stem cells convert into liver
cells within days without fusion. Nature Cell Biol 2004; 6:532-539.
S19. Willenbring H, Bailey AS, Foster M. Akkari Y, Dorrell C, Olson S, et al. Myelomonocytic cells are
sufficient for therapeutic cell fusion in liver. Nature Med 2004; 10:744-748.
S20. Ishikawa H, Nakao K, Matsumoto K, Nishimura D, Ichikawa T, Hamasaka K, et al. Bone marrow
engraftment in a rodent model of chemical carcinogenesis but no role in the histogenesis of hepatocellular
carcinoma. Gut 2004; 53:884-889.
S21. Abedi M, Greer DA, Colvin GA, Demers DA, Dooner MJ, Harpel JA, et al. Tissue injury in marrow
transdifferentiation. Blood Cells Mol Dis 2004; 32:42-46.
S22. Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Lack of a fusion
requirement for development of bone marrow-derived epithelia. Science 2004; 305:90-93.
S23. Stadtfeld M, Graf T. Assessing the role of hematopoietic plasticity for endothelial and hepatocyte
development by non-invasive lineage tracing. Development 2004; 132:203-212.
S24. Cantz T, Sharma AD, Jochheim-Richter A, Arseniev L, Klein C, Manns M, et al. Reevaluation of
bone marrow-derived cells as a source for hepatocyte regeneration. Cell Transplant 2004; 13:659-666.
3
S25. Allen KJ, Cheah DMY, Lee XL, Pettigrew-Buck NE, Vadolas J, Mercer JFB, et al. The potential of
bone marrow stem cells to correct liver dysfunction in a mouse model of Wilson’s disease. Cell Transplant
2004; 13:765-773.
S26. Terai S, Sakaida J, Yamamoto N, Omori K, Watanabe T, Ohata S, et al. An in vivo model for
monitoring trans-differentiation of bone marrow cells into functional hepatocytes. J Biochem 2003;
134:551-558.
S27. Yamamoto N, Terai S, Ohata S, Watanabe T, Omori K, Shinoda K, et al. A subpopulation of bone
marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver.
Biochem Biophys Res Commun 2004; 313:1110-1118.
S28. Sakaida I, Terai S, Yamamoto N, Aoyama K, Ishikawa T, Nishina H, et al. Transplantation of bone
marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 2004; 40:1304-1311.
S29. Fang B, Shi M, Liao L, Yang S, Liu Y, Zhao RC. Systemic infusion of FLK1+ mesenchymal stem
cells ameliorates carbon tetrachloride-induced liver fibrosis in mice. Transplantation 2004; 78:83-88.
S30.Yannaki E, Athanasiou E, Xagorari A, Constantinou V, Batsis I, Kaloyannidis P, et al. G-CSF-primed
hematopoietic stem cells or G-CSF per se acelerate recovery and improve survival after liver injury,
predominantly by promoting endogenous repair programs. Exp Hematol 2005; 35:108-119.
S31. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, et al. Bone marrow as a
potential source of hepatic oval cells. Science1999; 284:1168-1170.
S32. Avital I, Inderbitzen D, Aoki T, Tyan DB, Cohen AH, Ferraresso C, et al. Isolation, characterization,
and transplantation of bone marrow-derived hepatocyte stem cells. Biochem Biophys Res Commun 2001;
288:156-164.
S33. Avital I, Feraresso C, Aoki T, Hui T, Rozga J, Demetriou A, et al. Bone marrow-derived liver stem
cell and mature hepatocyte engraftment in liver undergoing rejection. Surgery 2002; 132:384-390.
S34. Sato Y, Igarashi Y, Hakamata Y, Murakami T, Kaneko T, Takahashi M, et al. Establishment pf AlbDsRed2 transgenic rat for liver regeneration research. Biochem Biophys Res Commun 2003; 311:478-481.
S35. Dahlke MH, Popp FC, Bahlmann FH, Aselmann H, Jäger MD, Neipp M, et al. Liver regeneration in a
retrorsine/CCl4-induced acute liver failure model: do bone marrow-derived cells contribute? J Hepatol
2003; 39:365-373.
4
S36. Arikura J, Inagaki M, Huilling X, Azaki A, Onodera K, Ogawa K, et al. Colonization of albuminproducing hepatocytes derived from transplanted F344 rat bone marrow cells in the liver of Nagase’s
analbuminemic rats. J Hepatol 2004; 41:215-221.
S37. Menthena A, Deb N, Oertel M, Grozdanov PN, Sandhu J, Shah S, et al. Bone marrow progenitors are
not the source of expanding oval cells in injured liver. Stem Cells 2004; 22:1049-1061.
S38. Huiling X, Inagaki M, Arikura J, Ozaki A, Onondera K, Ogawa K, et al. Hepatocytes derived from
peripheral blood stem cells of granulocyte-colony stimulating factor treated F344 rats in analbuminemic rat
livers. J Surg Res 2004; 122:75-82.
S39. Okumoto K, Saito T, Hattori E, Ito J, Suzuki A, Misawa K, et al. Expression of Notch signaling
markers in bone marrow cells that differentiate into a liver cell lineage in a rat transplant model.
Hepatology Res 2005; 31:7-12.
S40. Sato Y, Matsui K, Ajiki T, Igarashi Y, Takahashi M, Murakami T, et al. Can a bone marrow cell
contribute to organ regeneration? In vivo analysis using transgenic rats with reporter genes. Transplant Proc
2005; 37:273-275.
S41. Hua L, Aoki T, Jin Z, Nishino N, Yasuda D, Izumida Y, et al. Elevation of serum albumin levels in
Nagase analbuminemic rats by allogeneic bone marrow cell transplantation. Eur Surg Res 2005; 37:111114.
S42. Zhao D, Lei J, Chen R, Yu W, Zhang X, Li S, et al. Bone marrow-derived mesenchymal stem cells
protect against experimental liver fibrosis in rats. World J Gastroenterol 2005; 11:3431-3440.
S43. Danet GH, Luongo JL, Butler G, Lu MM, Tenner AJ, Simon MC, et al. C1qRp defines a new human
stem cell population with hematopoietic and hepatic potential. Proc Natl Acad Sci USA 2002; 99:1044110445.
S44.Beerheide W, von Mach MA, Ringel M, Fleckenstein C, Schumann S, Renzing N, et al.
Downregulation of β2-microglobulin in human cord blood somatic stem cells after transplantation into
livers of SCID-mice: an escape mechanism of stem cells? Biochem Biophys Res Commun 2002; 294:
1052-1063.
5
S45. Wang X, Ge S, McNamara G, Hao Q, Crooks GM. Albumin-expressing hepatocyte-like cells develop
in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic
stem cells. Blood 2003; 101:4201-4208.
S46. Newsome PN, Johannessen I, Boyle S, Dalakis E, McAulay KA, Samuel K, et al. Human cord bloodderived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion.
Gastroenterology 2003; 124:1891-1900.
S47. Kakinuma S, Tanaka Y, Chinzei R, Watanabe M, Shimizu-Sato K, Hara Y, et al. Human umbilical
cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 2003; 21:217-227.
S48. Ishikawa F, Drake CJ, Yang S, Fleming PA, Minamiguchi H, Visconti RP, et al. Transplanted human
cord blood cells give rise to hepatocytes in engrafted mice. Ann NY Acad Sci 2003; 996:174-185.
S49. Kollett O, Shivtiel S, Chen Y, Suriawinata J, Thung SN, Dabeva MD, et al. HGF, SDF-1, and MMP-9
are involved in stress-induced human CD 34+ stem cell recruitment to the liver. J Clin Invest 2003;
112:160-169.
S50. Fang B, Shi M, Liao L, Yang S, Liu Y, Zhao RC. Multiorgan engraftment and multilineage
differentiation of human fetal Flk+/CD 31-/CD 34- progenitors. J Hematotherapy Stem Cell Res 2003;
12:603-613.
S51.Tanabe Y, Tajima F, Nakamura Y, Shibasaki E, Wakejima M, Shimomura T, et al. Analyses to clarify
rich fractions in hepatic progenitor cells from human umbilical cord blood and cell fusion. Biochem
Biophys Res Commun 2004; 324:711-718.
S52. DiCampli C, Piscaglia AC, Pierelli L, Rutella S, Bonanno G, Alison MR, et al. A human umbilical
cord blood stem cell rescue therapy in a murine model of toxic liver injury. Digest Liver Dis 2004; 36:603613.
S53. Ruhnke M, Ungeforen H, Nussler A, Martin F, Brulport M, Schormann W, et al. Differentiation of
invitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells.
Gastroenterology 2005; 128:1774-1786.
S54. Sharma AD, Cantz T, Richter R, Eckert K, Henschler R, Wilkens L, et al. Human cord blood stem
cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver. Am J Pathol
2005; 167:555-564.
6
S55. Sato Y, Araki H, Kato J, Nakamura K, KawanoY, Kobune M, et al. Human mesenchymal stem cells
xenografted directly into rat liver differentiated into hepatocytes without fusion. Blood 2005; 106:756-763.
S56. Almeida-Porada G, Porada CD, Chamberlain J, Torabi A, Zanjani ED. Formation of human
hepatocytes by human hematopoietic cells in sheep. Blood 2004; 104:2582-2590.
S57. Noia G, Pierelli L, Bonanno G, Monego G, Perillo A, Rutella S, et al. The intracoelemic route: a new
approach for in utero human cord blood stem cell transplantation. Fetal Diagn Ther 2004; 19:13-22.
S58. Kögler G, Sensken S, Airey JA, Trapp T, Müschen M, Feldhahn N, et al. A new human somatic stem
cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 2004; 200:123135.
S59. Zeng F, Chen M, Katsumata M, Huang W, Gong Z, hu W, et al. Identification and characterization of
engrafted human cells in human/goat xenogeneic transplantation chimerism. DNA Cell Biol 2005; 24:403404.
S60. Turrini P, Monego G, Gonzalez J, Cicuzza S, Bonnano G, Zelano G, et al. Human hepatocytes in mice
receiving pre-immune injection with human cord blood cells. Biochem Biophys Res Commun 2005; 326:
66-73.
S61. Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, et al. Liver from bone
marrow in humans. Hepatology 2000; 32: 11-16.
S62. Alison MR, Poulson R, Jeffrey R, Dhillon AP, Quaglia A, Jacob J, et al. Hepatocytes from nonhepatic adult stem cells. Nature 2000; 406:257.
S63. Korbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, Albitar M, et al. Hepatocytes and epithelial
cells of donor origin in recipients of peripheral blood stem cells. N Engl J Med 2002; 346:738-746.
S64. Bittmann I, Hentrich M, Bise K, Kolb HJ, Löhrs U. Endothelial cells but not epithelial cells or
cardiomyocytes are partially replaced by donor cells after allogeneic bone marrow and stem cell
transplantation. J Hematotherap Stem Cell Res 2003; 12:359-366.
S65. Esch JS, Knoefel WT, Klein M, Ghodsizad A, Fuerst G, Poll LW, et al. Portal application of
autologous CD133+ bone marrow cells to the liver: A novel concept to support liver regeneration. Stem
Cells 2005; 23:463-470.
7
S66. Fogt F, Beyser KH, Poremba C, Zimmerman RL, Khettry U, Ruschoff J. Recipient-derived
hepatocytes in liver transplants: a rare event in sex-mismatched transplants. Hepatology 2002; 36:173-176.
S67. Hove WR, Hoek B, Bajema IM, Ringers J, Krieken JHJM, Lagaaij EL. Extensive chimerism in liver
transplants: vascular endothelium, bile duct epithelium, and hepatocytes. Liver Transpl 2003; 9:552-556.
S68. Ng IO, Chan K, Shek W, Lee JM, Fong DY, Lo C, et al. High frequency of chimerism in transplanted
livers. Hepatology 2003; 38:989-998.
S69. Wu T, Cieply K, Nalesnik MA, Randhawa PS, Snozogni A, Bellamy C, et al. Minimal evidence of
transdifferentiation from recipient bone marrow to parenchymal cells in regenerating and long-surviving
human allografts. Am J Transpl 2003; 3:1173-1181.
S70. Grassi A, Susca M, Ravaioli M, Grazi GL, D’Errico A, Bontandani A, et al. Detection of recipient’s
cells in liver graft using antibodies to mismatched HLA Class I antigens. Liver Transplant 2004; 10:14061414.
S71. Idilman R, Erden E, Kuzu I, Ersoz S, Karasu Z, Karayalcin K, et al. Recipient-derived hepatocytes in
sex-mismatched liver allografts after liver transplantation: early versus late transplant biopsies.
Transplantation 2004; 78:1647-1652.
S72. Kleeberger W, Rothämel T, Glöckner S, Flemming P, Lehmann U, Kreipke H. High frequency of
epithelial chimerism in liver transplants demonstrated by microdissection and STR-analysis. Hepatology
2002; 35:110-116.
S73. Niku M, Ilmonen L, Pessa-Morikawa T, Iivanainen A. Limited contribution of circulating cells to the
development and maintenance of nonhematopoietic bovine tissues. Stem Cells 2004; 22:12-20.
S74. Johnson KL, Samura O, Nelson JL, McDonnell WM, Bianchi DW. Correspondence. Significant fetal
cell microchimerism in a nontransfused woman with hepatitis C: evidence for long-term survival and
expansion. Hepatology 2002; 36:1295-1296.
S75. Khosrotehrani K, Johnson KL, Cha DH, Salomon RN, Bianchi DW. Transfer of fetal cells with
multilineage potential to maternal tissues. J Am Med Assoc 2004; 292:75-80.
S76. Stevens AM, McDonnell WM, Mullarkey ME, Pang JM, Leisenring W, Nelson JL. Liver biopsies
from human females contain male hepatocytes in the absence of transplantation. Lab Invest 2004; 84:16031609.
8
S77. Guettier C, Sebagh M, Buard J, Feneux D, Ortin-Serrano M, Gigou M, et al. Male cell
microchimerism in normal and diseased female livers from fetal life to adulthood. Hepatology 2005; 42:3543.