Research Projects Funded or Part Funded by SCaRF Applicant Dr Chris Popham Mr Robert Warr Dr David Etherington D Henshaw Project 5 Projects Statistical analysis Frenchay Production of monoclonal antibodies to melanoma PCR method of detecting tumour cells in the blood of patients with melanoma An Ecological Study of Cancer Incidence and Radon Levels in South West England A case-control study of Malignant Melanoma in south West England, including measurement of Radon exposure Dr John ICRC Research Laboratory Frenchay Kempshead Supervision of work by Dr Zhu and Mr Warr Dr Ningwen SCaRF Research Fellow - Published papers include:Zhu Cutaneous Melanoma – Pathology and Surgical Management. Sub-lethal effects of exposing the human melanoma cell line SKmel-23 to 532nm laser light. Cutaneous malignant melanoma in the young Prognostic significance of allelic losses in primary melanoma Changes in the levels of intergrin and focal adhesion kinase (FAK) in human melanoma cells following 532nm laser treatment Dr Chris What is the relationship between personal phenotype Bower characteristics and prognostic histological parameters in patients with malignant melanoma in the south west of England. Prof Jean A study of the prevalence and aetiology of benign Golding melanocytic naevi in childhood as a key to the identification of precursors of malignant melanoma Prof S MacNeil Investigation of the protective effect of α-MSH on Dr N Zhu inflammation induced melanoma invasion Dr Julia An epidemiological study of late relapsing melanoma Newton Bishop Dr Tim Eisen Characterisation of melanocortin receptors on melanoma cell lines in clinical melanoma samples Dr Colin Brn-2 expression controls melanoma proliferation and is Goding directly regulated by β-catenin Dr Jacqui Travel expenses to present paper at British Association of Shields Dermatologists meeting – Presentation of the Shields Index Mr Rowan Role of a novel anti-antiogenic iso form of VEGF in skin Pritchard Jones cancer 15 February 2016 Date 1988-1993 SCaRF Funding £11,416 £400 £64,788 1995-1996 £8,000 1993-1996 £11,109 1997-1999 28,750 1994-2000 £132,566 1998-2000 £12,000 1999-2001 £38,162 2002 £18,140 2001-2003 £34,158 2002-2003 £7,520 2001-2003 £5,700 1981-1987 2003 2003-2005 £295 £31,056 Dr Dave Bates Employment of SCaRF Fellow Mr Darryl Dunn at MicroVascular Laboratories University of Bristol Dr Victoria Top up funding to allow the completion of project Giblin “Development of a Diagnostic tool for cutaneous melanoma” Dr Dave Bates Refurbishment of laboratory facilities to enable the culture of human melanoma cell lines” Dr Dave Bates “Isolation, identification and characterisation of human melanoma cell lines” *Funding for this project obtained from a separate charitable Trust but administered and monitored by SCaRF Professor Julia Leading on from findings of her previous research this award Newton Bishop was made to “ Investigate the possibility that Vitamin A supplements may have an effect on survival from melanoma”. Professor “Cell senescence and the biology of melanoma development” Dorothy This application was withdrawn before any payment was actually made Bennett 2005 - 2009 2006 £20,000 per year £2,000 2006 £13,500 2006 2006 £5,000 per year for 3 years £8,991 2007 £62,002 2007 £50,000 2008-2011 £54,337 2009- 2011 £43,081 2009-2010 £8,000 2009-2011 £25,846 2010-2013 £37,000 2011-2012 £30,610 2011-2012 £32,920 2013- 2014 £56.982 Oct 2013 £4,900 after the applicant succeeded in obtaining funding from another source Dr Jeanette Woolard Katharine Parker BSc Dr Jeanette Woolard Dr M P Carty “Dynamic measurement of melanoma using Bioluminescence Imaging” purchase of a bioluminescence imaging camera The molecular basis of chemosensitivity of malignant melanoma to tricyclic anti depressants” “Impact of small molecular inhibitors in metastatic melanoma” The response of human keratinocytes and melanocytes to DNA damage by long wavelength irradiation” purchase of a UVA irradiation chamber. Dr R Morgan “The HOX/PBX interaction as a therapeutic target in melanoma” Prof J Newton The establishment of a new research consortium Bishop BioGenoMEL Prof D Bates Impact of splice factor kinase knockdown in metastatic melanoma Mr R Angiogenesis and metastatic melanoma via the lymphatics. Pritchard-Jones Resolving the paradox Dr M Cross Validation of anti-angiogenesis and anti-lymphangiogenesis as Mr R Pritchard a potential modality for vemurafenib resistant melanoma Jones Dr M Emmett Dr M Cross Purchase of cell culture Hood to enable increase in production Mr R Pritchard of melanoma cell lines Jones Mr M Emmett 15 February 2016