Academia Sinica E-news No. 28 B. Division of Life Sciences:(5 approved applications) Project No. AS-97-TP-B01 AS-97-TP-B02 Title of Applications Program Directors Institutes Coral Holobiont Biodiversity: Pattern and Functional Approaches to the Coral-associated Microbial Diversity Allen Chen Research Centre for Biodiversity, AS 1-1. Spatial and Temporal Dynamics of Symbiont Communities, Photophysiological Differences, and Variability of Holobiont Biomarkers in Scleractinian corals Allen Chen Research Centre for Biodiversity, AS 1-2. Nutrient Interactions between Symbiodinium and Cnidarian Hosts and Their Roles on the Process and Mechanism of Forming Successful Symbiosis Jih-Terng Wang Institute Biotechnology, Ta-Jen Univ. of Science and Technology 1-3. Comparative Biodiversity of Microbes Associated with Scleactinian Corals from Taiwan: Spatial, Temporal and Symbiont Variations Sen-Lin Tang Research Centre for Biodiversity, AS 1-4. Spatial and Temporal Dynamics and Diversity of the Coral-associated Microbes Based on Laboratory Cultivation Approaches Wen-Ming Chen Department Seafood Science, Kaohsiung Marine Univ. Novel Pathological Pathways for Improved Yijuang Chern Diagnosis and Treatments of Huntington's Disease – from Basic to Clinical Approaches Institute of Biomedical Sciences, AS 2-0. PPG-Center Project Yijuang Chern Institute of Biomedical sciences, AS 2-1. Development of Neuroprotective Strategies Targeting on Specific Bioenergetic Defects for Huntington’s Disease-II Yijuang Chern Institute of Biomedical sciences, AS 2-2(與分支計畫2-1合併) Pang-hsien Tu Identification of Novel Therapeutic Drugs and Targets for Huntington’s Disease Based on Inhibition of GAPDH Nuclear Translocation Institute of Biomedical sciences, AS 2-3(與分支計畫2-1合併) Mechanistic Study on the Regulation of Translation and Trafficking Yu-May Lee Institute of Biological Chemistry, AS 2-4. The Application of Stem Cells as Both Biomarker and Treatment for Huntington’s Disease Hung Li Institute of Molecular Biology, AS 2-5. Discover Novel Biomarkers in Chiung-Mai Cerebrospinal Fluid and Peripheral Blood of Chen Both Huntington’s Disease (HD) Patients Department of Neurology, Chang Gung Memorial Academia Sinica E-news No. 28 and Mice and Test the Therapeutic Effects of Anti-oxidants AS-97-TP-B03 AS-97-TP-B05 AS-97-TP-B06 Function and Mechanism Studies of Ubiquitin/Proteasome-Mediated Proteolytic Regulation in Arabidopsis Hospital Hongyong Fu Institute Plant and Microbial Biology, AS 3-1. Biochemical Properties and Functional Hongyong Fu Differentiation of the Major Ubiquitin Receptors in Arabidopsis Institute Plant and Microbial Biology, AS 3-2. Proteomics and Genetics Analysis of Long-Chi Wang Phytohormone Functions Regulated by 26S Proteasome in Arabidopsis Thaliana Institute Plant and Microbial Biology, AS 3-3. Fine-tuning the Light-responsive Transcriptional Regulators in Arabidopsis: Mechanistic Studies of Selective Protein Degradation Institute Plant and Microbial Biology, AS Shu-Hsing Wu Utilization of a Rice T-DNA Insertion Mutant Su-May Yu Library: Discovery and Functional Analysis of Genes Essential for Rice Growth and Stress Tolerance Institute of Molecular Biology, AS 5-1. Functional Analysis of Rice Genes Involved in Sugar Signaling Su-May Yu Institute of Molecular Biology, AS 5-2. Functional Analysis of Rice Genes Involved in Hormone Signaling Tuan-Hua Ho Institute of Plant and Microbial Biology, AS Functional Studies of Molecular Mechanism Jen-Leih Wu of Growth Factor Signaling Pathways Involved in Hepatocellular Carcinoma Formation and Liver Development of Zebrafish Institute of Cellular and Organismic Biology, AS 6-1. Deregulation of Insulin-like Growth Jen-Leih Wu Factor Signaling to Study the Mechanism of Hepatocellular Carcinoma (HCC) and Liver Development in Zebrafish Institute of Cellular and Organismic Biology, AS 6-2. Functional Analyses of KLF6 and KLF8 Sheng-Ping L. on Liver Development and the Evaluation of Hwang Their Potential Roles in the Development of Hepatocellular Carcinoma Institute of Cellular and Organismic Biology, AS 6-3. The Study of Functional Role of Wnt/beta-catenin Signaling Regulators in the Development of Zebrafish Hepatocellular Carcinoma Institute of Bioscience and Biotechnology, NTOU Guor Mour Her