CURRICULUM VITAE
David Clement Whitcomb, MD PhD
Giant Eagle Foundation Professor of Cancer Genetics
Professor of Medicine (with tenure), Cell Biology & Physiology, and Human Genetics
Chief, Division of Gastroenterology, Hepatology and Nutrition
University of Pittsburgh School of Medicine
Name:
David C. Whitcomb, MD, PhD
Birth Date:
December 7, 1955
Home Address:
9609 Park Edge Drive
Allison Park, PA 15101
Birth Place:
Warsaw, Indiana
Home Phone:
(412) 635-7707
Citizenship:
USA
Business Address:
Mezzanine Level, C-Wing, PUH
University of Pittsburgh
200 Lothrop Street
Pittsburgh, PA 15261
E-Mail Address: Whitcomb@pitt.edu
http://www.pancreas.org
http://www.pitt.edu/~whitcomb
Business Phone:
(412) 578-9515
Spouse:
Business Fax:
(412) 578-9537
Christine Allison Whitcomb
EDUCATION AND TRAINING
UNDERGRADUATE:
Dates Attended
Institution
Degree and year
9-74 to 6-77
Grace College
Winona Lake, Indiana
9-77 to 5-78
Manchester College
BS 1978
North Manchester, Indiana
Biology-Chemistry
Dates Attended
Institution
Degree and year
Major
9-78 to 12-79
Ohio State University
Columbus, Ohio
MS 1979
Margaret Nishikawara PhD
Physiology
12-79 to 4-83
Ohio State University
Columbus, Ohio
PhD 1983
Margaret Nishikawara PhD
Physiology
9-80 to 12-85
Ohio State University
Columbus, Ohio
MD 1985
Medicine
-
Major
-
GRADUATE:
POST GRADUATE:
Dates Attended
Institution
Program Director and Discipline
7-85 to 6-86
Duke University
Durham, NC
Dr. Ralph Corey
Internal Medicine (internship)
1
POST GRADUATE (cont.):
Dates Attended Institution
Program Director and Discipline
7-86 to 12-86
7-87 to 6-88
Duke University
Durham, NC
Dr. Ralph Corey
Internal Medicine (residency)
7-88 to 12-90
Duke University
Durham, NC
Dr. Ian Taylor
Gastroenterology (fellowship)
ACADEMIC:
Dates Inclusive
Institution
Title
1-91 to 6-91
Duke University
Durham, NC
Associate in Medicine
(Gastroenterology, Emergency Med.)
7/91 to present
University of Pittsburgh
Pittsburgh, PA
Assistant Professor of Medicine
(Gastroenterology and Hepatology)
1/92 to 1988
University of Pittsburgh
Pittsburgh, PA
Assistant Professor of Cell Biology
and Physiology
9-93 to 6-94
VA Pittsburgh Med Center
Director of Nutrition Support Service
6-94 to 11-97
VA Pittsburgh Medical Center
Chief, Section of Gastroenterology
5-95 to 5-99
University of Pittsburgh
College of Medicine
Director, Center for Genomic Sciences
(Now Genomic and Proteomic Core Lab)
11-96
American College of
Gastroenterology
Fellow, American College of
Gastroenterology (#7858)
7-97
University of Pittsburgh
Graduate Faculty Appointment
1998
University of Pittsburgh
Associate Professor of Medicine.
5-99 to 9-00
University of Pittsburgh
Interim Chief, Div. Gastroenterology and
Hepatology
10-99
University of Pittsburgh
Associate Professor of Medical Genetics
9-00
University of Pittsburgh
Chief, Div. Gastroenterology and Hepatology
10-01
University of Pittsburgh
Professor of Medicine
2006
University of Pittsburgh
Giant Eagle Foundation Professor of Cancer
Genetics (endowed Chair)
CERTIFICATION AND LICENSURE
SPECIALTY CERTIFICATION:
MEDICAL LICENSURE
Certifying Board
Year
American Board of Internal Medicine (#124200)
Gastroenterology (#124200)
1989
1991
Licensing Board
State
2
Board of Medical Examiners
State Board of Medicine
NC (#30517)
PA (MD044425L)
MEMBERSHIP IN PROFESSIONAL AND SCIENTIFIC SOCIETIES
Year
Organization
1982
Landacre Society (Treasurer, 1983-84, President, 1984-85) (Ohio State)
1983
Sigma Xi, The Scientific Research Society
1988
American College of Physicians
1989
American Federation of Clinical Research
1992
American Gastroenterological Association
1992
International Association of Pancreatology
1992
American Pancreatic Association
1992
Society for Neuroscience
1994
American Motility Society
1994
American Physiological Society
1996
American College of Gastroenterology
2000
American Society for Clinical Research
2000
Gastrohepatology Global Academic Faculty
2001
Association of Subspecialty Professors
2005
American Society of Clinical Oncology
2006
McGowan Institute for Regenerative Medicine, Member Faculty
2010
Collaborative Association for Pancreatic Education and Research (CAPER)
2010
Clinical Translational Research Institute (University of Pittsburgh)
---------------------------------------------------------------------------------------------------------HONORS
1981
1983
1985
1985
1985
1984
1989
1993
1995
1997
1997
1999
1998
1999
2000
2001
2001
2002
2002
2002
2003
2003
2003
2006
2006
Phi Kappa Phi Honor Society
ICSABER Graduate Student Research Award (Ohio State)
Upjohn Research Achievement Award
Ohio State Univ. Dept. of Surgery Medical Student Award
Ohio State Univ. Dept. of Medicine Research Award
AGA National Student Research Abstract Competition, Runner Up
Winner, Clinical Vignette Competition
American College of Physicians Annual Meeting
San Francisco CA April 14, 1989
Winner, First Annual Pittsburgh Gut Club Award
Elected member of the Nominating Committee, AGA Pancreatic Disorders Section
Elected Secretary, Midwest Gut Club
Member, AGA Committee on Gastroenterology Research
Elected Counselor, American Gastroenterology Association and Vice Chairman,
Pancreatic Disorders Section.
Elected Counselor (and Future President) American Pancreatic Association
Elected American Society for Clinical Research (ASCI “Young Turk”)
Counselor, International Association of Pancreatology
Chairman, Pancreatic Disorders Section, American Gastroenterology Association
Pancreatic Cancer Progress Review Group of the National Cancer Institute
Guest Editor, Pancreatology – Special Focus Issue on Inherited Diseases of the Pancreas
“Hilda Schwartz Visiting Professorship at Baylor College of Medicine Gastroenterology
Course, Houston, TX
Nominating Committee, American Gastroenterological Association
Edwin Englert Jr. Endowed Memorial Visiting Lectureship, February 20, 2003
Hinda R. Kopelman Memorial Award and Lecture, Canadian Digestive Disease Week,
Banff, Alberta, February 24, 2003
President, American Pancreatic Association
University of Pittsburgh 2006 Honors Convocation for Giant Eagle Foundation, Endowed
Chair
Inaugural Hans Fromm MD Memorial Lecture, Dartmouth University, NH
3
2006-2008
2008
2008
2009
2009-2010
2010
2010
2011
“Top Doctor” in Gastroenterology, Pittsburgh Magazine
"International Who's Who of Professionals" – 2008
National Pancreas Foundation Courage Award (Physician of the Year), June 22, 2009
Yale University, Kushlan Visiting Professor and Lectureship, March 3-5, 2009
Best Doctors in America 2009-2010 database (voted by peers)
Who’s Who in America (included in the 2011 Edition)
Top 75 Gastroenterologists in America, ASG Review, November, 2010
Fellow, American Gastroenterological Association
PUBLICATIONS
Peer Reviewed Manuscripts
1.
Whitcomb DC, O'Dorisio TM, Cataland S, Nishikawara MT. Theoretical basis for a new in vivo
radioreceptor assay. Am J Physiol 1985;249 (Endocrinol. Metab. 12):E555-E560. PMID:
4083340.
2.
Whitcomb DC, O'Dorisio TM, Cataland S, Shetzline MA, Nishikawara MT. Identification of tissue
insulin receptors: Use of a unique in vivo radioreceptor assay. Am J Physiol 1985;249
(Endocrinol. Metab. 12):E561-E567. PMID: 3909827.
3.
Whitcomb DC, Gilliam FR, Grant AO. Marked QRS complex abnormalities and sodium channel
blockade of propoxyphene reversed with lidocaine. J Clin Invest 1969;84:1629-1636. PMID:
2553778.
4.
Wall TC, Phillips III HR, Stack RS, Mantell S, Aronson L, Boswick J, Sigmon K, DiMeo M, Chaplin
D, Whitcomb DC, Pasi D, Zawodniak M, Hajisheik M, Hegde S, Barker W, Tenney R, Califf RM.
Results of high dose intravenous urokinase for acute myocardial infarction. Am. J. Cardiol.
1990;65:124-131. PMID: 2296881.
5.
Whitcomb DC, Taylor IL, Vigna SR. Characterization of saturable binding sites for circulating
pancreatic polypeptide in rat brain. Am. J. Physiol. 1990;259 (Gastrointest. Liver Physiol. 22):
G687-G691. PMID: 2221079
6.
Gettys TW, Garcia R, Savage K, Whitcomb DC, Kanayama S, Taylor IL. Insulin-sparing effects of
pancreatic polypeptide in congenitally obese rodents. Pancreas 1991;6(1):46-53. PMID: 1994379
7.
Mantyh PW, Stimson ER, Ghilardi JR, Allan CJ, Dahl CE, Whitcomb DC, Vigna SR, Winters HV,
Labenski ME, Maggio JE. Reversible in vitro growth of Alzheimer’s disease -amyloid plaques.
Bulletin of Clinical Neurosciences 1991;56:73-85. PMID: 1608956.
8.
Nguyen TD, Wolfe MS, Heintz GG, Whitcomb DC, Taylor IL. High affinity binding sites for
pancreatic polypeptide on rat liver membranes. J. Biol. Chem. 1992;267(13):9416-9421. PMID:
1577769.
9.
Maggio JE, Stimson ER, Ghilardi JR, Allen CJ, Dahl CE, Whitcomb DC, Vigna SR, Vinters HV,
Labenski ME, Mantyh PW. Reversible in vitro growth of Alzheimer’s disease beta-amyloid
plaques. Proc. Natl. Acad. Sci. 1992;89:5462-5466. PMID: 1608956.
10.
Whitcomb DC, Vigna SR, McVey DC, Taylor EL. Localization and characterization of pancreatic
polypeptide receptors in the rat adrenal gland. Am. J. Physiol. 1992;262 (Gastrointest. Liver
Physiol. 25):G532-G536. PMID: 1550240
11.
Whitcomb DC, Martin S, Trellis D, Evans B, Becich M. “Diaphragm-like” Stricture and Ulcer of
the Colon During Diclofenac Treatment. Arch. Intern. Med. 1992;152:2341-2343. PMID:
1444695.
4
12.
Hernandez EJ, Whitcomb DC, Vigna SR, Taylor IL. Saturable Binding of Circulating Peptide YY in
the Dorsal Vagal Complex of the Rat. Am. J. Physiol. 1994;266 (Gastrointest. Liver Physiol. 29)
G511-G516. PMID: 8166288.
13.
Whitcomb DC, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol
use. JAMA 1994;272 (23):1845-1850. PMID: 7990219.
14.
Whitcomb DC, Martin SP, Schoen RE, Jho HD. Chronic Abdominal Pain Caused Thoracic Disc
Herniation. Am. J. Gastro. 1995;90(5), 835-837. PMID: 7733103.
15.
Utter A, Gross F, Whitcomb DC, Brown M, Pusateri J, Kriska A, DaSilva S, Robertson R. The
effects of acute exercise on gallbladder function in an adult female population. Med. Sci. Sport
Exerc. 1996;28(3):280-284. PMID: 8776215.
16.
Huh YB, Rose S, Schoen RE, Hunt S, Whitcomb DC, Finkelstein S. Colonic Bacillary
Angiomatosis. Ann. Intern. Med. 1996;124(8):735-737. PMID: 8633833.
17.
Whitcomb DC, Preston RA, Aston CE, Sossenheimer MJ, Barua PS, Zhang Y, Wong-Chong A,
White GJ, Wood PG, Gates L, Ulrich C, Martin SP, Post JC, Ehrlich GD. A Gene for Hereditary
Pancreatitis Maps to a 19 cM Locus on Chromosome 7q35. Gastroenterology 1996;110:19751980. PMID: 8964426.
18.
Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates
LK, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD. Hereditary
pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nature Genetics
1996;14(2):141-145. PMID: 8841182.
19.
Whitcomb DC, Puccio AM, Vigna SR, Taylor IL, Hoffman GE. Distribution of pancreatic
polypeptide receptors in the rat brain. Brain Research 1997;760(1-2):137-149. PMID: 9237528.
20.
Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK, Perrault J, Whitcomb DC.
Hereditary pancreatitis and the risk of pancreatic cancer. J. Natl. Cancer Inst. 1997; 89 (6):442446. PMID: 9091646.
21.
Sossenheimer MJ, Aston C, Ehrlich GD, Gates L, Martin S, Ulrich C, Preston R, Whitcomb DC.
Clinical characteristics of hereditary pancreatitis in a large family based on high-risk haplotype.
Am. J. Gastro. 1997;92(7):1113-1116. PMID: 9219780.
22.
Gorry MC, Gabbaizedeh D, Furey W, Gates LK Jr, Preston RA, Aston CE, Zhang Y, Ulrich C,
Ehrlich GD, Whitcomb DC. Mutations in the cationic trypsinogen gene are associated with
recurrent acute and chronic pancreatitis. Gastroenterology 1997;113:1063-1068. PMID: 9322498.
23.
Seymour NE, Spector SA, Andersen DK, Elm MS, Whitcomb DC. Over expression of hepatic
pancreatic polypeptide receptors in chronic pancreatitis. Journal of Surgical Research
1998;76(1):47-52. PMID: 9695738.
24.
Rossi L, Whitcomb DC, Ehrlich GD, Gorry M, Parvin S, Sattar S, Ali L, Azad Kahn AK, Gyr. N
Lack of R117H mutation in the cationic trypsinogen gene in patients with tropical pancreatitis from
Bangladesh. Pancreas 1998;17:278-280. PMID: 9788542.
25.
Ulrich II D, Wood P, Hadac EM, Kopras E, Whitcomb DC, Miller LJ. Elucidation of the Cellular
distribution of secretin receptor expression in rat pancreas. Am. J. Physiol 1999;275:G1437G1444.
26.
Manocha AP, Sossenheimer MJ, Martin SP, Sherman KE, Whitcomb DC, Ulrich II CD.
Prevalence and predictors of severe acute pancreatitis in patients with acquired immune
deficiency syndrome (AIDS). Am J Gastroenterol 1999;94(3):784-789. PMID: 1086666.
27.
Bracher GA, Manocha AP, DeBanto J, Gates LK, Whitcomb DC, Bleau BL, Ulrich CD, Martin SP.
Endoscopic pancreatic duct stenting to treat pancreatic ascites. Gastrointest Endosc 1999
Jun;49(6):710-5. PMID: 10343214.
5
28.
Lerch MM, Ellis IH, Whitcomb DC, Keim V, Simon P, Howes N, Rutherford S, Domschke W, Imrie
CW, Neoplolemus JP. Maternal inheritance pattern of hereditary pancreatitis in patients with
pancreatic carcinoma. J Natl Cancer Inst 1999 Apr 21;91(8):723-4. PMID: 10218513.
29.
Ford M, Whitcomb DC. Analysis of hereditary pancreatitis-associated cationic trypsinogen gene
mutations in exon 2 and 3 by enzymatic mutation detection (EMD) from a single 2.2kb PCR
product. Molecular Diagnosis 1999;4(3);211-218. PMID: 10553021.
30.
Guarita DR, Deng X, Huh YB, Wood PG, Reeve JR, Whitcomb DC. PYY regulates pancreatic
exocrine secretion through multiple receptors in the awake rat. Dig. Dis. Sci. 2000;45(9):16961702. PMID: 11052307.
31.
Utter AC, Whitcomb DC, Nieman DC, Butterworth DE, Vermillion SS. Exercise training and
gallbladder function in an obese female population. Med.Sci. Sports Exerc. 2000;32(1):41-45.
32.
Darden DL, Hu FZ, Ehrlich MD, Gorry MC, Dressman D, Li HS, Whitcomb DC, Hebda PA, Dohar
JE, Ehrlich GD. RNA Differential Display of Scarless Wound Healing in Fetal Rabbit Indicates
Downregulation of a CCT Chaperonin Subunit and Upregulation of a Glycophorin-like gene
Transcript. Journal of Pediatric Surgery 2000;35(3):406-419. PMID: 10726679.
33.
Li H-S, Hebda PA, Kelly LA, Ehrlich GD, Whitcomb DC, Dohar JE. Up-regulation of
Prostaglandin EP4 receptor messenger RNA in fetal rabbit skin wound. Archives OtolaryngologyHead & Neck Surgery 2000;126(11):1337-1343. PMID: 11074830.
34.
Pfützer RH, Barmada MM, Brunskil APJ, Finch R, Hart PS, Neoptolemos J, Furey WF, Whitcomb
DC. SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic
pancreatitis. Gastroenterology 2000;119:615-623. PMID 10982753.
35.
Howes Rutherford S, O’Donnell M, Mountford R, Ellis I, Greenhalf W, Whitcomb DC, Imrie C,
Drumm B, Neoptolemos JP. A new polymorphism for the R122H mutation in hereditary
pancreatitis. Gut 2001;48(2):247-50. PMID: 11156648.
36.
Deng X, Guarita DR, Wood PG, Kreiss C, Whitcomb DC. PYY potently inhibits pancreatic
exocrine secretion mediated through CCK-secretin-stimulated pathways but not 2-DG stimulated
pathways in awake rats. Dig Dis & Sci 2001;46;1:156-165. PMID: 11270780.
37.
Amann ST, Gates Jr. LK, Preston RA, Aston CE, Pandya A, Whitcomb DC. Expression and
penetrance of the hereditary pancreatitis phenotype in monozygotic twins. Gut 2001;48:542-547.
PMID: 11247900.
38.
Li HS, Thompson BS, Zhang JY, Deng XY, Wood PG, Eagon PK, Whitcomb DC. Chronic ethanol
consumption induces gene expression of pancreatic monitor peptide, but not SPINK1/PSTI-56, in
rats. Pancreas 2001;23(2):117-124. PMID: 11484913.
39.
Deng X, Wood PG, Sved AF, Whitcomb DC. The area postrema lesions alter the inhibitory
effects of peripherally infused pancreatic polypeptide on pancreatic secretion. Brain Research
2001;202(1):18-29. PMID: 11376591.
40.
Deng X, Guarita D, Pedroso M, Kreiss C, Wood P, Sved A, Whitcomb DC. PYY inhibits CCK
stimulated pancreatic secretion through the area postrema in unanesthetized rats. American
Journal of Physiology 2001;281(2):R645-53. PMID: 1148870.
41.
Li HS, Zhang JY, Deng XY, Thompson BS, Wood PG, Stolz DB, Eagon PK, Whitcomb DC. Rat
mitochondrial ATP synthase ATP5G3: cloning and up-regulation in the pancreas after chronic
ethanol feeding. Physiol. Genomics 2001;6(2):91-98. PMID: 11459924.
42.
Applebaum SE, Peters JA, O’Connell JA, Aston CE, Whitcomb DC. Motivations and concerns of
patients with access to genetic testing for hereditary pancreatitis. Am J Gas 2001;96(5):16101617. PMID: 11374708.
6
43.
Rossi L, Pfützer RH, Parvin S, Ali L, Sattar S, Kahn AKA, Gyr N, Whitcomb DC. SPINK1/PSTI
Mutations are associated with tropical pancreatitis in Bangladesh, a preliminary report.
Pancreatology 2001;1:242-245. PMID: 12120202.
44.
Deng X, Guarita DR, Pedroso MRA, Wood PG, Kreiss C, Sved AF, Whitcomb DC. Area
Postrema Lesion Alters the effects of peptide YY on 2-DG-stimulated pancreatic exocrine
secretion. Digestive Diseases and Sciences 2001;46(11):2460-2469. PMID: 11713954.
45.
Etemad B, Whitcomb DC. Chronic Pancreatitis: Diagnosis, Classification and new genetic
developments. Gastroenterology 2001;120:682-707. PMID: 11179244.
46.
Lowenfels AB, Maisonneuve P, Whitcomb DC, Lerch MM, DiMagno EP. Evidence for geneenvironment interaction in pancreatic cancer. JAMA 2001;286,169.
47.
Applebaum-Shapiro SE, Finch R, Pfützer RH, Hepp LA, Gates L, Amann S, Martin S, Ulrich II CD,
Whitcomb DC. Hereditary pancreatitis in North America: The Pittsburgh-Midwest Multi-center
Pancreatic Study Group Study. Pancreatology 2001;1(5):439-443. PMID: 12120221.
48.
Ellis I, Lerch MM, Whitcomb DC. Genetic testing for hereditary pancreatitis: guidelines for
indications, counseling, consent and privacy issues. Pancreatology 2001;1:405-415. PMID:
12120217.
49.
Pfützer R, Whitcomb DC. SPINK1 Mutations are associated with multiple phenotypes.
Pancreatology 2001;1:457-460. PMID: 12120224.
50.
Threadgold J, Greenhalf W, Ellis I, Howes N, Lerch MM, Simon P, Ihse I, Jansen J, Charnley R,
Laugier R, Frulloni L, Olah A, Delhaye M, Schaffalitzky OB, de Muckadell, Andren-Sandberg A,
Imrie CW, Martinek J, Gress TM, Mountford R, Whitcomb DC, Neoptolemos JP. The N34S
mutation of PSTI (SPINK1) is associated with a familial pattern of Idiopathic Chronic Pancreatitis
but does not cause the disease. Gut 2001;162 50(5):675-681. PMID: 11950815.
51.
Pfützer R, Tadic SD, Li HS, Thompson BS, Zhang JY, Ford ME, Eagon PK, Whitcomb DC.
Pancreatic cholesterol esterase, ES-10 and FAEESIII gene expression are increased in pancreas
and liver but not brain or heart with long term ethanol feeding in rats. Pancreas 2002;25(1):101106. PMID: 12131779.
52.
Uhl W, Warshaw A, Imrie C, Bassi C, McKay CJ, Lankisch PG, Carter R, Di Magno E, Banks PA,
Whitcomb DC, Dervenis C, Ulrich CD, Satake K, Ghaneh P, Hartwig W, Werner J, McEntee G,
Neoptolemos JP, Buchler MW. IAP Guidelines for the Surgical Management of Acute
Pancreatitis. Pancreatology. 2002;2(6):565-573. PMID: 12435871.
53.
Pfützer RH, Myers E, Applebaum-Shapiro S, Finch R, Ellis I, Neoptolemos J, Kant JA, Whitcomb
DC. Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant
hereditary pancreatitis. Gut 2002;50:271-272. PMID: 11788572.
54.
Eberle MA, Pfutzer R, Pogue-Geile KL, Bronner MP, Crispin D, Kimmey MB, Duerr RH, Kruglyak
L, Whitcomb DC, Brentnall TA. A new susceptibility locus for autosomal dominant pancreatic
cancer maps to chromosome 4q32-34. American J of Human Genetics 2002;70(4):1044-8.
PMID: 11870593.
55.
Wang L, Rudert WA, Grishin A, Dombrosky-Ferlan P, Sullivan K, Deng X, Whitcomb DC, Corey
S. Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4
isoforms. Biochemical and Biophysical Research Communications 2002;293:1426-1430. PMID:
12054674.
56.
Hassan Z, Mohan V, Ali L, Allotey R, Barakat K, Faruque O, Deepa R, McDermott MF, Jackson
AE, Cassell P, Curtis D, Gelding SV, Vijayaravaghan S, Gyr N, Whitcomb DC, Azad Khan AK,
Hitman GA. SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects
from the Southern Indian sub-continent. Am J Hum Genet. 2002;Oct;71(4):964-8. PMID:
12187509.
7
57.
Tadic SD, Elm MS, Li H, Van Londen GJ, Subbotin VM, Whitcomb DC, Eagon PK Sex
differences in hepatic gene expression in a rat model of ethanol-induced liver injury. J Appl
Physiol 2002;93:1057-1068. PMID: 12183503.
58.
Orenstein SR, Shalaby TM, Finch R, Pfuetzer RH, DeVandry S, Chensny LJ, Bannada MM,
Whitcomb DC. Autosomal dominant infantile gastroesophageal reflux disease: exclusion of a
13q14 locus in five well characterized families. Am J Gastroenterol. 2002 Nov;97(11):2725-32.
PMID: 12425539.
59.
Schneider A, Suman A, Rossi L, Barmada MM, Beglinger C, Parvin S, Sattar S, Ali L, Khan AK,
Gyr N, Whitcomb DC. SPINK1/PSTI mutations are associated with tropical pancreatitis and type
II diabetes mellitus in Bangladesh. Gastroenterology 2002 Oct;123(4):1026-30. PMID: 12360464.
60.
DeBanto JR, Goday PS, Pedroso MR, Iftikhar R, Fazel A, Nayyar S, Conwell DL, Demeo MT,
Burton FR Whitcomb DC, Ulrich CD 2nd, Gates LK Jr. Acute pancreatitis in children. Am J
Gastroenterol 2002;97(7):1726-31. PMID: 12135026.
61.
Schneider A, Pogue-Geile K, Barmada MM, Myers-Fong E, Thompson BS, Whitcomb DC.
Hereditary, familial and idiopathic chronic pancreatitis are not associated with polymorphisms in
the tumor necrosis factor-alpha (TNF-alpha) promoter region or the TNF receptor 1 (TNFR1)
gene. Genet Med 2003;Mar-Apr;5(2):120-5. PMID: 12644782.
62.
Schneider A, Pfützer RH, Barmada MM, Slivka A, Martin J, Whitcomb DC. Limited contribution of
the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis – a preliminary
report from the United States. Dig Dis Sci 2003;48(6):1110-1115. PMID: 12822871.
63.
Schneider A, Barmada MM, Slivka A, Martin JA, Whitcomb DC. Analysis of tumor necrosis factoralpha, transforming growth factor-beta1, interleukin-10, and interferon-gamma polymorphisms in
patients with alcoholic chronic pancreatitis. Alcohol 2004; 32:19-24. PMID: 15066699.
64.
Schneider A, Tögel S, Barmada MM, Whitcomb DC. Genetic analysis of the glutathione stransferase genes MGST1, GSTM3, GSTT1 and GSTM1 in patients with hereditary pancreatitis.
J Gastroenterol 2004;39:783-7. PMID: 15338373.
65.
Schneider A, Barmada MM, Slivka A, Martin JA, Whitcomb DC. Clinical characteristics of patients
with idiopathic chronic pancreatitis and SPINK1 mutations. Scand J Gastroenterol 2004
Sep;39(9):903-4. PMID: 15513391.
66.
Gaisano HY, Sheu L, Whitcomb DC. Alcohol chronic pancreatitis involves displacement of
Munc18c from the pancreatic acinar basal surface. Pancreas 2004;28.395-400. PMID: 15097857.
67.
Whitcomb DC, Ermentrout GB. A mathematical model of the pancreatic duct cell generating high
bicarbonate concentrations in pancreatic juice. Pancreas 2004;2029:E30-E40. PMID: 15257112.
68.
Deng X, Wood PG, Eagon PK, Whitcomb DC. Chronic alcohol-induced alterations in the
pancreatic secretory control mechanisms. Dig Dis Sci 2004;49:805-819. PMID: 15259503.
69.
Howes N, Lerch MM, Greenhalf W, Stocken DD, Ellis I, Simon P, Truninger K, Ammann R,
Cavallini G, Charnley RM, Uomo G, Delhaye M, Spicak J, Drumm B, Jansen J, Mountford R,
Whitcomb DC, Neoptolemos JP. Clinical and Genetic Characteristics of Hereditary Pancreatitis in
Europe. J Clin Gastro 2004;2:252-261. PMID: 15017610.
70.
Tschop M, Castaneda TR, Joost HG, Thone-Reineke C, Ortmann S, Klaus S, et al. Physiology:
does gut hormone PYY3-36 decrease food intake in rodents? Nature 2004;430(6996). PMID:
15243972.
71.
Pogue-Geile K, Mackey J, George R, Wood P, Lee K, Moser A, Lyons-Weiler A, Whitcomb DC. A
New Microarray, Enriched in Pancreas and Pancreatic Cancer cDNAs to Identify Genes Relevant
to Pancreatic Cancer. Cancer Genomics and Proteomics 2004, 1:371-386.
8
72.
Oruc N, Whitcomb DC. The Functional Angiotensin Converting Enzyme Gene I/D Polymorphism
Does not Alter Susceptibility to Chronic Pancreatitis. JOP. 2004 Nov 10;5(6):457-63. PMID:
15536282.
73.
Rossi L, Parvin S, Hassan Z, Hildebrand P, Keller U, Ali L, Beglinger C, Azad Khan AK, Whitcomb
DC, Gyr N. Diabetes mellitus in Tropical Chronic Pancreatitis is not just a secondary type of
diabetes. Pancreatology 2004;4(5):461-7. PMID: 15258409.
74.
Schneider A, Barmada MM, Slivka A, Martin JA, Whitcomb DC. Transforming growth factorbeta1, interleukin-10 and interferon-gamma cytokine polymorphisms in patients with hereditary,
familial and sporadic chronic pancreatitis. Pancreatology 2004;4(6):490-494. PMID: 15316224.
75.
Khalid A, Pal R, Sasatomi E, Swalsky P, Slivka A, Whitcomb D, Finkelstein S. Use of
microsatellite markers loss of heterozygosity in accurate diagnosis of pancreaticobiliary
malignancy from brush cytology samples. Gut 2004 Dec; 53(12):1727-1729.
76.
Whitcomb DC. Mechanisms of Disease: advances in understanding the mechanisms leading to
chronic pancreatitis. Nature Clin Practice, Gastro Hepatol; November 2004;1(1):46-52. PMID:
16265044.
77.
Whitcomb DC. Value of Genetic Testing in the Management of Pancreatitis. Gut 2004
Nov;53(11):1710-1717. PMID: 15479696.
78.
Deng X, Wood PG, Eagon PK, Whitcomb DC. Rapid Adaptation of Pancreatic Exocrine Function
to Short Term Alcohol Feeding in Rats. Pancreatology 2005;5:183-195. PMID: 15855815.
79.
Whitcomb DC. Inflammation and Cancer V. Chronic pancreatitis and pancreatic cancer. Am J
Physiol Gastrointest Liver Physiol 2004;287(2):G315-9. PMID: 15246966.
80.
Deng X, Wang L, Elm MS, Gabbaizedeh D. Diorio GJ, Eagon PE, Whitcomb DC Chronic alcohol
consumption accelerates fibrosis in response to cerulein-induced pancreatitis in the rat. Am J
Pathol. 2005 Jan;166(1):93-106. PMID: 15632003.
81.
Papachristou GI, Sass DA, Avula H, Lamb J, Lokshin A, Barmada MM, Slivka A, Whitcomb DC.
Is the monocyte chemotactic protein-1-2518 G Allele a Risk Factor For Severe Acute
Pancreatitis? Clin Gastroenterol Hepatol 2005 May;3(5):475-81. PMID: 15880317.
82.
Schneider A, Lawrence EC, Barmada MM, Norris JM, Hamman RF, Marshall JA, Ferrell RE,
Whitcomb DC. The SPINK1 N34S Mutation Is Not Associated With Type 2 Diabetes Mellitus in a
Population of the United States.” Diabet Med 2005 Jun;22(6):744-8. PMID: 15910626.
83.
Orenstein SR, Whitcomb DC, Barmada MM. Challenges of Examining Complex Genetic
Disorders Like GERD. J Pediatr Gastroenterol Nutr 2005 Sep;41 Suppl 1:s17-9. PMID:
16131953.
84.
Aoun E, Papachristou GI, Whitcomb D, Ahmad I, Slivka A. Acute deterioration of a woman
following acute pancreatitis with pseudocysts. Nat Clin Pract Gastroenterol Hepatol 2005 Nov;
2(11):545-549. PMID: 16355160.
85.
Whitcomb DC, Aoun E, Vodovotz Y, Clermont G, Barmada MM. Evaluating disorders with a
complex genetics basis: the future roles of meta-analysis and systems biology. Dig Dis Sci 2005
Dec; 50(12):2195-2202. PMID: 16416160.
86.
Khalid A, Finkelstein S, Thompson B, Kelly L, Hanck C, Godfrey T, Whitcomb D. A 93 year old
man with the PRSS1 R122H mutation, low SPINK1 expression and without pancreatitis: insights
into phenotypic nonpenetrance. Gut 2006 May;55(5):728-31. Epub 2005 Dec 14. PMID:
16354799.
87.
Deng X, Wood PG, Eagon PK, Whitcomb DC. Rapid Adaptation of Pancreatic Exocrine Function
to Short-Term Alcohol Feeding in Rats. Pancreatology 2005;5(2-3):183-95. PMID: 15855815.
9
88.
Hauskrecht M, Pelikan R, Malehorn DE, Bigbee WL, Lotze MT, Zeh HJ, Whitcomb DC, LyonsWeiler J. Feature selection for classification of SELDI-TOF-MS proteomic profiles. Appl
Bioinformatics 2005;4(4):227-246. PMID: 16309341.
89.
Khalid A, McGrath KM, Zahid M, Wilson M, Brody D, Swalsky P, Moser AJ, Lee KK. Slivka A,
Whitcomb DC, Finkelstein S. The role of pancreatic cyst fluid molecular analysis in predicting cyst
pathology. Clin Gastroenterol Hepatol 2005 Oct;3(10):967-973. PMID: 16234041.
90.
Pogue-Geile KL, Lyons-Weiler J, Whitcomb DC. Molecular overlap of fly circadian rhythms and
human pancreatic cancer. Cancer Lett. 2006 (ePub Jan 29). PMID: 16451817.
91.
Fortunato F, Deng X, Gates LK, McClain CJ, Bimmler D, Graf R, Whitcomb DC. Pancreatic
response to endotoxin after chronic alcohol exposure: switch from apoptosis to necrosis? Am J
Physiol Gastrointest Liver Physiol 2006 Feb;290(2):G232-241. PMID: 15976389.
92.
Schneider A, Lamb J, Barmada MM, Cuneo A, Money ME, Whitcomb DC. Keratin 8 mutations
are not associated with familial, sporadic and alcoholic chronic pancreatitis from the United
States. Pancreatology 2005 Dec 1;6(1-2):103-108. PMID: 16327287.
93.
Sass DA, Papachristou GI, Lamb J, Barmada MM, Brand RE, Money ME, Hawes RH, Cotton PB,
Slivka A, Whitcomb DC. The MCP-1 2518 A/G polymorphism is not a susceptibility factor for
chronic pancreatitis. Pancreatology19; 6 (4): 297-300. 2006. PMID: 16636603.
94.
Papachristou GI, Papachristou DJ, Avula H, Slivka A, Whitcomb DC. Obesity increases the
severity of acute pancreatitis: Performance of APACHE-O score and correlation with the
inflammatory response. Pancreatology 1006; 6 (4): 279-285, 2006. PMID: 1663660.
95.
Whitcomb DC. Clinical practice. Acute pancreatitis. N Engl J Med 2006 18;354 (20): 2142-50.
PMID: 16707751.
96.
Papachristou GI, Papachristou DV, Morinville VD, Slivka A, Whitcomb DC. Chronic alcohol
consumption is a major risk factor for pancreatic necrosis in acute pancreatitis. Am J
Gastroenterol 2006 Nov 101(1):2605-10. PMID: 17029614.
97.
Greer JB, Whitcomb DC. The Role of BRCA1 and BRCA2 Mutations in Pancreatic Cancer. Gut
2007 May 56(5):601-5. PMID: 16973716.
98.
Pogue-Geile KL, Chen R, Bronner MP, Crnogorac-Jurcevic T, White Moyes K, Dowen S, Otey
CA, Crispin DA, George RD, Whitcomb DC and Brentnall TA. Palladin Mutation Causes Familial
Pancreatic Cancer and Suggests a New Cancer Mechanism. PLoS Medicine 2006 Dec (3) 12
2216-2228. PMID: 17194196.
99.
Papachristou GI, Malehorn DE, Lamb J, Slivka A, Bigbee WL, Whitcomb DC. Serum proteomic
patterns as a predictor of severity in acute pancreatitis. Pancreatology 2007 11;7(4):317-324,
2007. PMID: 17627096.
100.
Bhat YM, Papachristou GI, Park JS, Lamb J, Slivka A, Whitcomb DC. Functional polymorphisms
of the GSTT-1 gene do not predict the severity of acute pancreatitis in the United States.
Pancreatology 2007(2-3):180-186. PMID: 17592232.
101.
Aoun E, Slivka A, Papachristou DJ, Gleeson FC, Whitcomb DC, Papachristou GI. Rapid
evolution from the first episode of acute pancreatitis to chronic pancreatitis in human subjects.
JOP. 2007 Sep 7;8(5):573-8. PMID: 17873461.
102.
Raina A, Krasinskas AM, Greer JB, Lamb J, Fink E, Moser AJ, Zeh HJ, Slivka A, Whitcomb DC.
Serum immunoglobin G fraction 4 levels in pancreatic cancer: elevations not associated with
autoimmune pancreatitis. Arch Pathol Lab Med 2008 Jan 132(1):48-53. PMID: 18181673..
103.
Greer JB, Whitcomb DC, Brand RE. Genetic predisposition to pancreatic cancer: a brief
review. Am J Gastroenterol. 2007 Nov;102(11):2564-9. PMID: 17958761.
10
104.
Morinville VD, Lowe ME, Elinoff BD, Whitcomb DC. Hereditary pancreatitis amlodipine trial; a pilot
study of a calcium-channel blocker in hereditary pancreatitis. Pancreas 2007 Nov;35(4):308-12.
PMID: 18090235.
105.
Aoun E, Chang C-CH, Greer JB, Papachristou GI, Barmada MM, Whitcomb DC. Pathways to
injury in chronic pancreatitis; Decoding the role of the high-risk SPINK1 N34S haplotype using
meta-analysis. PLoS ONE. 2008;3(4):e2003. PMID: 18414673.
106.
Whitcomb DC, Yadav D, Slivka A. Multicenter approach to recurrent acute and chronic
pancreatitis in the United States: the North American Pancreatitis Study 2 (NAPS2).
Pancreatology 2008;8:520-31. PMID: 18765957.
107.
Grote T, Siwak DR, Fritsche HA, Joy C, Mills GB, Simeone D, Whitcomb DC, Logsdon CD.
Validation of reverse phase protein array for practical screening of potential biomarkers in serum
and plasma: accurate detection of CA19-9 levels in pancreatic cancer. Proteomics. 2008
Aug;8(15):3051-60. PMID: 18615426.
108.
Muddana V, Lamb J, Greer JB, Elinoff B, Hawes RH, Cotton PB, Anderson M, Brand RE, Slivka
A, Whitcomb DC. Association between calcium sensing receptor (CASR) gene polymorphisms
and chronic pancreatitis in a US population: Role of SPINK1 and alcohol. World Journal of
Gastroenterology 2008 July 28;14 ( 28): 4486-91. PMID: 18680227.
109.
Oruc N, Papachristou GI, Avula H, Slivka A, Lamb J, Whitcomb DC. Angiotensin converting
enzyme gene DD genotype neither increases susceptibility to acute pancreatitis or influences
disease severity. Journal of the International Hepato Pancreato Biliary Association 2009;11(1):
45-9. PMID: 19590623.
110.
Lazarev M, Lamb J, Barmada MM, Dai F, Anderson MA, Max MB, Whitcomb DC. Does the painprotective GTP cyclohydrolase haplotype significanty alter the pattern or severity of pain in
humans with chronic pancreatitis? Mol Pain 2008 Nov;17:4(1):58. PMID: 19014702.
111.
Oruc N, Lamb J, Whitcomb DC, Sass DA. The ACE gene I/D polymorphism does not affect the
susceptibility to or prognosis of PBC. Turk J Gastroenterol 2008 Dec;19(4):250-3. PMID:
19119484.
112.
Muddana V, Whitcomb DC, Khalid A, Slivka A, Papachristou GI. Elevated serum creatinine as a
marker of pancreatic necrosis in acute pancreatitis. Am J Gastroenterol 2009 Jan;104(1):164-70.
PMID: 19098865.
113.
Sharma A, Mudanna V, Lamb J, Greer JB, Papachristou GI, Whitcomb DC. Low Serum
Adiponectin Levels are Associated with Systemic Organ Failure in Acute Pancreatitis. Pancreas
2009 Nov;38(8):907-12. PMID: 19696691.
114.
Raina A, Yadav D, Kransinskas AM, McGrath K, Khalid A, Sanders SP, Whitcomb DC, Slivka A.
Evaluation and Management of Autoimmune Pancreatitis: Experience at a large US center. Am J
Gastroenterol. 2009 Sep;104(9):2295-306. PMID: 19532132..
115.
Papachristou GI, Mudanna V, Yadav D, O'Connell M, Sanders MK, Slivak A, Whitcomb DC.
Comparison of BISAP, Ranson’s, APACHE-II and CTSI scores in predicting organ failure,
complications and mortality in acute pancreatitis. Am J Gastroenterol. 2010 Feb;105(2):435-41.
PMID: 19861954.
116.
Aoun E, Muddana V, Papachristou GI, Whitcomb DC. SPINK1 N34S is strongly associated with
recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis even.
Am J Gastroenterol 2010 Feb 105(2):446-51. PMID: 19888199.
117.
Whitcomb DC, Greer J. Germ-line mutations, pancreatic inflammation, and pancreatic cancer.
Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S29-34.
11
118.
Papachristou GI, Muddana VN, Yadav D, Whitcomb DC. Epidermal growth factor serum levels
and the 61G/A polymorphism in patients with acute pancreatitis. Dig Dis Sci 2010 Feb 3. PMID:
20127414.
119.
Smith LM, Sharif, S, Brand R, Fink E, Lamb J, Whitcomb DC. MUTYH Exon 7 and 13 mutations
associated with colorectal cancer (MAP Syndrome) are not commonly associated with sporadic
pancreatic cancer. Pancreatology 2010 Jan 28;9(6):793-796. PMID: 20110747
120.
Chakraborty S, Kaur S, Muddana V, Sharma N, Wittel UA, Papachristou GI, Whitcomb D, Brand
RE, Batra SK. Elevated serum neutrophil gelatinase-associated lipocalin is an early predictor of
severity and outcome in acute pancreatitis. Am J Gastroenterol 2010 Feb 23. PMID: 20179686.
121.
Aoun E, Chen J, Reighard D, Gleeson FC, Whitcomb DC, Papachristou GI. Diagnostic accuracy
of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: A meta-analysis.
Pancreatology 2010 Jan 21;9(6):777-785. PMID: 20110745.
122.
Diergaarde b, Brand R, Lamb J, Cheong SY, Stello K, Barmada MM, Feingold E, Whitcomb DC.
Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1)
gene in pancreatic carcinogenesis. Pancreatology 2010 May 17;10(2-3):194-200. PMID:
20484958.
123.
Whitcomb DC, Lehman GA, Vasileva G, Malecka-Panas E, Gubergrits N, Shen Y, SanderStruckmeier S, Caras S. Pancrelipase delayed-release capsules (CREON) for exocrine
pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind
randomized trial. Am J Gastroenterol 2010 May 25 (in press). PMID: 20502447.
124.
Whitcomb DC, Muddana V, Langmead CJ, Houghton FD Jr, Guenther A, Eagon PK, Mayerle J,
Aghdassi AA, Weiss FU, Evans A, Lamb J, Clermont G, Lerch MM, Papchristou GI. Angiopoietin2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure
in patients with acute pancreatitis from the United States and Germany. Am J Gastroenterol 2010
Oct;105(10):2287-92. PMID: 20461065.
125.
Mullady DK, Yadav D, Amann ST, O’Connell M, Barmada MM, Elta GH, Scheiman JM,
Wamsteker EJ, Chey WD, Korneffel ML, Weinman BM, Slivka A, Sherman S, Hawes RH, Brand
RE, Burton FR, Lewis MD, Gardner TB, Gelrud A, DiSario J, Baillie J, Banks PA, Whitcomb DC,
Anderson MA; NAPS2 Consortium. Chronic pancreatitis characterized by constant pain
regardless of severity is associated with poorer quality of life, greater disability, and increased
resource utilization. Gut 2011 Jan;60(1):77-84. PMID: 21148579.
126.
Yadav D, Slivka A, Sherman S, Hawes RH, Anderson MA, Burton FR, Brand RE, Lewis MD,
Gardner TB, Gelrud A, DiSario J, Amann ST, Baillie J, Lawrence C, O’Connell M, Lowenfels AB,
Banks P, Whitcomb DC. Smoking is under recognized as a risk factor for chronic pancreatitis.
Pancreatology 2011 Jan 18;10(6):713-9. PMID: 21242712.
127.
Brand R, Nolen B, Zeh H, Allen P, Eloubeidi M, Goldberg M, Elton E, Arnoletti J, Christein J,
Vickers S, Landsittel D, Whitcomb DC, Grizzle W, Lokshin A. Serum biomarkers panels for the
detection of pancreatic cancer. Clinical Cancer Research 2011 Feb 15;17(4):805-16.
128.
Fasanella KE, Krasinskas a, Schoedel KE, Sasatomi E, Slivka a, Whitcomb DC, Sanders M, Nodit
L, Raab S, McGrath KM, Ohori NP, Khalid a. DNA mutational differences in cytological
specimens from pancreatic cancer and cholangiocarcinoma. Pancreatology 2010 Aug
19;10(4):429-433. PMID: 20720444.
129.
Mudanna V, Park J, Lamb J, Yadav D, Papachristou GI, Hawes RH, Brand R, Slivka A, Whitcomb
DC. Are genetic variants in the platelet-derived growth factor beta gene associated with chronic
pancreatitis? Pancreas 2010 Nov;39(8):1215-9 epub 2010 Aug 14. PMID: 20717068.
130.
Burton F, Alkaade S, Collins D, Muddana V, Slivka A, Brand RE, Gelrud A, Banks PA, Sherman
S, Anderson MA, Romagnuolo J, Lawrence C, Baillie J, Gardner TB, Lewis MD, Amann ST, Lieb
JG 2nd, O'Connell M, Kennard ED, Yadav D, Whitcomb DC, Forsmark CE; North American
12
Pancreatic Study Group. "Use and perceived effectiveness of non-analgesic medical therapies
for chronic pancreatitis in the United States" Alimentary Pharmacology & Therapeutics. Aliment
Pharmacol Ther 2010; Oct 29. PMID: 21083584
131.
Greer JB, Yazer MH, Raval JS, Barmada MM, Brand RE, Whitcomb DC. Significant association
between ABO blood group and pancreatic cancer. World J Gastroenterol 2010; Nov
28;16(44):5588-91. PMID: 21105191
132.
Schneider A, Larusch J, Sun X, Aloe A, Lamb J, Hawes R, Cotton P, Brande RE, Anderson MA,
Money ME, Banks PA, Lewis MD, Baillie J, Sherman S, Disario J, Burton FR, Gardner TB, Amann
ST, Gelrud A, George R, Rockacy MJ, Kassabian S, Martinson J, Slivka A, Yadav D, Oruc N,
Barmada MM, Frizzell R, Whitcomb DC. Combined bicarbonate conductance-impairing variants
in CFTR and SPINK1 are associated with chronic pancreatitis in patients without cystic fibrosis.
Gastroenterology 2011;33(1): 149-59. PMID: 20977904
133.
Cote GA, Yadav D, Slivka A, Hawes RH, Anderson MA, Burton FR, Brand RE, Banks PA, Lewis
MD, Disario JA, Gardner TB, Gelrud A, Amann ST, Baillie J, Money ME, O'Connell M, Whitcomb
DC, Sherman S; North American Pancreatitis Study Group. Alcohol and smoking as risk factors in
an epidemiology study of patients with chronic pancreatitis. Clin Gastroenterol Hepatol. 2010 Oct
25 (e-pub) PMID: 21029787
134.
Gubergrits N, Malecka-Panas E, Lehman GA, Vasileva G, Shen Y, Sander-Struckmeier S, Caras
S, Whitcomb DC. A 6-month, open-label clinical trial of pancrelipase delayed-release capsules
(CREON) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or
pancreatic surgery, Aliment Pharmacol Ther Aliment Pharmacol Ther. 2011 May;33(10):11521161. doi: 10.1111/j.1365-2036.2011.04631.x. Epub 2011 Mar 21. PMID: 21418260
135.
Wu BU, Bakker OJ, Papachristou GI, Besselink MG, Repas K, van Santvoort HC, Muddana V,
Singh VK, Whitcomb DC, Gooszen HG, Banks PA. Blood urea nitrogen in the early assessment
of acute pancreatitis: an international validation study. Arch Intern Med. 2011 Apr 11;171(7):66976. PMID: 21482842
136.
Sherman S, Shats O, Ketcham MA, Anderson MA, Whitcomb DC, Lynch HT, et al. PCCR:
Pancreatic Cancer Collaborative Registry. Cancer Inform. 2011;10:83-91. PMID 21552494
Books written and edited
1.
Inherited Diseases of the Pancreas. Ed. Whitcomb DC, Cohn JA and Ulrich II CD, series Medical
Clinics of North America, Volume 84, Number 3 (May, 2000). WB Saunders Company,
Philadelphia, PA. 248 pages.
2.
Pancreas. Section Editor, Whitcomb DC. Current Treatment Options in Gastroenterology,
Volume 4, Number 5 (October 2001). Current Science Inc., Philadelphia, PA 361-399.
3.
Inherited Diseases of the Pancreas. Ed. Whitcomb DC and Neoptolemos JP. Third International
Symposium on Inherited Diseases of the Pancreas, Pancreatology. Volume 1, No. 5 (2001).
Karger, New York, NY. 399-562.
4.
The Genetics Basis of Pancreatic Disorders, Edited by Durie P, Lerch MM, Lowenfels AB,
Maisonneuve P, Ulrich II CD, and Whitcomb DC, Published by Karger, Basil Switzerland, 2002
5.
Pancreatic Diseases: Novel Mechanisms and Management. Ed. Whitcomb DC, Brand R, and
Lerch M. Gastroenterology Clinics of North America, Volume 33, Number 4 (Dec, 2004). WB
Saunders Company, Philadelphia, PA.
6.
Molecular and Genetic Aspects of Gastrointestinal Disease, Guest Ed Whitcomb DC and
Sepulveda A. Clinics in Laboratory Medicine. Volume 25, Number 1. (March 2005) WB Saunders
Company, Philadelphia, PA. 230 pages.
13
7.
Molecular basis of inherited pancreatic disorders. Guest Ed. Lerch MM, Griesbacher T,
Whitcomb DC. Endocrinol Metab Clin North Am. Volume 35 Number (June 2006). WB Saunders
Company, Philadelphia, PA.
8.
Advances in the Diagnosis and Treatment of Pancreatic Diseases, Ed Whitcomb DC, Slivka A,
Lee KK. Gastroenterology Clinics of North America, Volume 36(2) (June 2007), W.B. Saunders
Company, Philadelphia, PA. 484 pages.
9.
The Pancreas – An Integrated Textbook of Basic Science, Medicine and Surgery. Ed Hans B,
Warshaw A, Buckler M, Kozarek R, Lerch M, Neoptolemos J, Shiratori K, Whitcomb D, Rau B.
Second Edition, Blackwell Publishing.
Chapters in major reference textbooks.
1.
Whitcomb DC, Cohn J. Pancreatic Dysfunction. In Textbook of Molecular Medicine, JL Jameson
Editor, Humana Press Inc, Totowa, NJ, 1998; pp 401-406.
2.
Whitcomb DC. “Neuroendocrine Control of the Exocrine Pancreas”, In Endocrinology of the
Gastrointestinal System, G Greeley Jr. Editor, Humana Press, Inc, 1998; pp 243-263.
3.
Whitcomb DC. Hereditary and Childhood Disorders of the Pancreas, Including Cystic Fibrosis.
Slessinger and Fortran, Chapter 47, Textbook of Gastroenterology, 2001.
4.
Whitcomb DC. Hereditary Diseases of the Pancreas. In: T Yamada, DH Albers, L Laine, N
Kaplowitz, C Owyang, DW Powell, editors. Textbook of Gastroenterology. Lippincott, Williams &
Wilkins, Philadelphia, PA. 2003; pp 2147-2165.
5.
Khalid A, Whitcomb DC. Hereditary Diseases of the Pancreas. In: T Yamada, DH Albers, L
Laine, N Kaplowitz, C Owyang, DW Powell, editors. Atlas of Gastroenterology (2003). Lippincott,
Williams & Wilkins, Philadelphia, PA. 2003; pp 545-552.
6.
Sharif S, Plevy S, Finn OJ, Whitcomb DC. “Hereditary Pancreatitis and its Link to Pancreatic
Cancer”, Chapter 8, In: Pancreatic Cancer, ed DD Van Hoff, DB Evans and RH Hruban, Jones
and Bartlett Publishers, Sadbury, MA. 2005; pp 119-132.
7.
Whitcomb DC, Lowe ME. Pancreatitis: Acute and Chronic. In: Walker WA, Goulet O, Kleinman
RE, Sherman PM, Shneider BL, Sanderson IR, editors. Pediatric Gastrointestinal Disease:
Pathophysiology, Diagnosis, Management. Hamilton (ON): BC: Decker; 2004; pp 1584-1597.
8.
Papachristou GI, Whitcomb DC. Etiopathogenesis of Chronic Pancreatititis: a Genetic Disease
With Some Precipitating Factors? In: Dόminguez-Muňoz JE. Clinical Pancreatology for
Practicing Gastroenterologists and Surgeons. Malden, MA: Blackwell Publishing, 2005; pp 192200.
9.
Whitcomb DC, LaSalle JM. Digestion and Absorption. In: Rose S, editor. Gastrointestinal and
Hepatobiliary Pathophysiology, Second Edition. Hayes Barton Press, 2005; pp 92-112.
10.
Whitcomb DC, Gabbaizadeh CM. Acute and Chronic Pancreatitis. In: Rose S, editor.
Gastrointestinal and Hepatobiliary Pathophysiology, Second Edition. Hayes Barton Press, 2005;
pp 249-277.
11.
Whitcomb DC, The Changing Paradigm of Chronic Pancreatitis. In: Balakarishnan V, Kumar H,
Sudhindran S, Unnikrishnan AG, editors. Chronic Pancreatitis and Pancreatic Diabetes in India.
Kochi, Kerala State, India. 2006; pp. 3-21.
12.
Deng X, Whitcomb DC, Pancreatic Polypeptide. In: Handbook of Biologically Active Peptides.
Abba J. Kastin, editor. 2006; pp. 1097-1107.
13.
Whitcomb DC. Chapter 138: Acute and Chronic Pancreatitis In: R.E. R, Bope ET, Kellerman RD,
eds. Conn's Current Therapy 2010. 62nd ed. Burlington, MA: Elsevier 2009
14
14.
Whitcomb DC, ME Lowe. Chapter 57, Hereditary, Familial and Genetic Disorders of the Pancreas
and Pancreatic Disorders in Childhood In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger
and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 9th
ed. Philadelphia, PA: Saunders - Elsevier 2009
15.
Papachristiou G, Singh V, Whitcomb DC. 2011. Acute Pancreatitis. In Textbook of Clinical
Gastroenterology and Hepatology Edited by Chris Hawkey, Wiley-Blackwell Inc, Oxford, England.
Reviews, invited published papers, proceedings of conferences and symposiums, monographs,
other book chapters and published letters.
1.
Whitcomb DC. Development and significance of an in vivo radioreceptor assay for polypeptide
hormones. PhD Dissertation, The Ohio State University, Columbus, Ohio. 1983.
2.
Whitcomb DC. Computer Assisted Instruction Programs. Ohio State University School of
Medicine. 1983. "Programs in Physiology, Membranes I: Biological Membranes and Body Fluids."
3.
Whitcomb DC. Computer Assisted Instruction Programs. Ohio State University School of
Medicine. 1983. "Programs in Physiology, Membranes II: Electrochemical Gradients and
Membrane Potentials."
4.
Whitcomb DC. Computer Assisted Instruction Programs. Ohio State University School of
Medicine. 1983. "Programs in Physiology, Membranes III: Action Potentials and their
Propagation".
5.
Whitcomb DC. Computer Assisted Instruction Programs. Ohio State University School of
Medicine. 1983. "Programs in Physiology, Nerve I: Synaptic Transmission of Nerve Impulses".
6.
Whitcomb DC. Bugs in the Blood: Acute staphylococcal septicemia and endocarditic is diagnosed
by staining the buffy coat. North Carolina Medical Journal 1986;17(6):293-295.
7.
Fox JC, Whitcomb DC. Alcohol deficiency, stress hormones and bad acidosis: aka AKA. North
Carolina Medical Journal. 1991;52(2):69-73
8.
Whitcomb DC, Vigna SR, Taylor IL. Pancreatic Polypeptide Receptors in Rat Brain. Methods in
Neuroscience 1993;11(19):317-333.
9.
Whitcomb DC, IL Taylor. A new twist in the brain-gut axis. Am. J. Med. Sci 1992;(5):334-338.
10.
Whitcomb DC. Pathophysiology of Nonsteroidal Anti-inflammatory Drug- induced intestinal
Strictures [letter]. Gastroenterology 1993;105(5):1590.
11.
Whitcomb DC. Acetaminophen poisoning and liver function. New England Journal of Medicine
[letter]. 1994;331:1311-1311.
12.
Whitcomb DC, Martin SP. Complicated acute pancreatitis. Gastroenterol. Endoscopy News
1994;Vol 45 (5):8-19.
13.
Whitcomb DC, Rakela J. Management of Acetaminophen Ingestion in the Outpatient Setting. J.
Clin. Outcome Manag. 1995;2(4):37-42.
14.
Whitcomb DC. The selling of acetaminophen - Reply. Gastroenterology 1995;109:2043-2045.
15.
Whitcomb DC, Block GD. Acetaminophen hepatotoxicity, Fasting, and Ethanol [letter]. JAMA
1995;274(4) 301-302
16.
Hench, PK, Weart CW, Whitcomb DC. Acetaminophen Toxicity: When to worry, what to do.
Patient Care. 1996;30(1):87-101.
15
17.
Whitcomb DC. Drug-Induced Hepatotoxicity [commentary]. Abstracts of Clinical Care Guidelines.
1996;Vol. 8(2):13-16
18.
Whitcomb DC. Hereditary Pancreatitis, Pancreatitis Forum 1997;1:12-15.
19.
Whitcomb DC, Jenne DE. Cloning the Peutz-Jeghers Gene and the Future of GI-Genomics.
(Selected Summary). Gastroenterology 1998;115:790.
20.
Whitcomb DC. Premature trypsin activation in hereditary pancreatitis - Reply (letter).
Gastroenterology 1998;115:796-799.
21.
Pfützer RH, Whitcomb DC. Trypsinogen mutations in chronic pancreatitis (letter).
Gastroenterology. 1999;117:1508-1509.
22.
Whitcomb DC Hereditary Pancreatitis: New insights into acute and chronic pancreatitis. Gut
1999;45:317-322.
23.
Whitcomb DC, Ulrich II CD. Hereditary Pancreatitis: New Insights, New Directions. Baillière’s
Clinical Gastroenterology 1999;13(2):253-263
24.
Whitcomb DC. Neurohormonal control of the pancreas. in Gastroenterology and Hepatology:
The Comprehensive Visual Reference. Volume 8 Pancreas, P Toskes, Volume Editor, M
Feldman, Series Editor. Current Medicine, Philadelphia PA, 1998; pp 1.1-1.18.
25.
Whitcomb DC, Gabbaizadeh D. Acute and Chronic Pancreatitis. In Gastrointestinal
Pathophysiology, S Rose Editor, Fence Creek Publishing , LLC, Madison, CT, 1998; pp 197-218.
26.
Whitcomb DC, LaSalle JM. Digestion and Absorption. In Gastrointestinal Pathophysiology, S
Rose Editor, Fence Creek Publishing , LLC, Madison, CT, 1998; pp 75-90.
27.
Whitcomb DC. Hereditary Pancreatitis. In Gastroenterology and Hepatology: The
Comprehensive Visual Reference. Volume 8 Pancreas, P Toskes, Volume Editor, M Feldman,
Series Editor. Current Medicine, Philadelphia PA, 1998; pp 10.1-10.17.
28.
Whitcomb DC, Schiot FV, Lee WM. Acetaminophen hepatotoxicity: The rest of the story.
(Selected Summaries). Gastroenterology 1998;114(5):1105-1106.
29.
Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK, Perrault J, Whitcomb DC.
Hereditary Pancreatitis (book chapter) In: CHRONIC PANCREATITIS. Proceedings of the 92nd
Course of the International School of Medical Sciences, Erice, Italy, October 14-15, 1996, Editors:
Eugene P. DiMagno, Alberto Maringhini. Series Editor A. Zichichi, World Scientific Publishing
Co., New Jersey, USA, 1999; pp 38-44.
30.
Whitcomb DC. The First International Symposium on Hereditary Pancreatitis. Pancreas
1999;18(1):1-12 (conference proceeding).
31.
Whitcomb DC. The Spectrum in Complications of Hereditary Pancreatitis: Is this a model for
future gene therapy? Gastroenterology Clinics of North America 1999;28(3):525-541. PMID:
10647527.
32.
Whitcomb DC, Applebaum S, Martin SP. Hereditary Pancreatitis and Pancreatic Cancer (book
chapter). Ann NY Acad Sci. Jun 30;1999;880:201-209.
33.
Whitcomb DC. Acute Pancreatitis - Mechanisms of Cell Injury - Genetics. In Pancreatic Disease:
State of the Art and Future Aspects of Research. E.P. DiMagno and P.G. Lankish (ed). Springer
Publishing Co. Heidelberg 1999;pp 3-13.
34.
Whitcomb DC. Early Trypsinogen Activation in Acute Pancreatitis. (Selected Summary)
Gastroenterology 1999;116(3):770-773.
16
35.
Whitcomb DC. Genes means pancreatitis: Cationic Trypsinogen R117H and N21I Mutations in
Japanese Hereditary Pancreatitis (Commentary). Gut 1999;44:150.
36.
Gates Jr LM, Ulrich II CD, Whitcomb DC. Hereditary Pancreatitis - Gene Defects and Their
Implications. (Book chapter) Surgical Clinics of North America. Volume 79(4); 711-722.
37.
Whitcomb DC, Pfützer RH, Slivka A. Alcoholic Chronic Pancreatitis. Current Treatment Opinions
in Gastroenterology 1999;2(4):273-282.
38.
Pfützer RH, Whitcomb DC. Hereditary Pancreatitis in Pancreas (Book Chapter), Published by the
Hellenic Society of Gastroenterology. University Studio Press, 1999;161-168.
39.
Whitcomb DC. Pancreatic bicarbonate secretion: role of CFTR and the sodium-bicarbonate
cotransporter. (Selected Summary) Gastroenterology. 1999 Jul;117(1):275-7.
40.
Whitcomb DC. Hereditary Pancreatitis: New insights into acute and chronic pancreatitis. (Leading
article) Gut 1999;45:317–322.
41.
Applebaum, SE, Kant JA, Whitcomb DC, Ellis IH. Genetic testing: counseling, laboratory and
regulatory issues and the EUROPAC protocol for ethical research in multi-center studies of
inherited pancreatic diseases. Medical Clin N Am. 2000;4(3):575-588.
42.
Pfützer, RH, Whitcomb DC. Wanted: A Consensus Nomenclature for Cationic Trypsinogen
Mutations- Reply, Gastroenterology. 2000;119 (1): 278-279
43.
Lowenfels AB, Maisonneuve P, Whitcomb DC. The Risk Factors for Cancer in Hereditary
Pancreatitis. Med Clin of N Am. 2000;84(3):565-574.
44.
Whitcomb DC. Trypsinogen mutations in hereditary pancreatitis: which nomenclature is
convenient?-Reply (letter). Gut 2000;46:873
45.
Whitcomb DC. Genetic Predispositions to Acute and Chronic Pancreatitis. Med Clin N Am.
2000;84(3):531-547.
46.
Pfützer R, Whitcomb DC. Acute Pancreatitis. (Invited Review) Current Opinion in
Gastroenterology 2000;16(5):410-413.
47.
Whitcomb DC, Pogue-Geile KL. A CF Modifier means meconium in mouse and man. (Selected
Summary) Gastroenterology 2000;119 (1), 268-269.
48.
Vargas HE, Whitcomb DC. Hepatitis C for Half a Century. (Selected Summary) Gastroenterology
Vol. 2000,119(5):1405-1407.
49.
Pfützer RH, Barmada MM, Whitcomb DC. SPINK1 Mutations in Chronic Pancreatitis- Reply
(letter), Gastroenterology. 2001;120:1060-1064
50.
Whitcomb DC. Genetic Alterations in Chronic Pancreatitis. Chronic Pancreatitis 2000: Novel
concepts in biology and therapy. Blackwell Science 2001.
51.
Whitcomb DC, Ulrich CD, Lerch MM, Durie P, Neoptolemos JP, Maisonneuve P, Lowenfels AB.
Third International Symposium on Inherited Diseases of the Pancreas. (conference report),
Pancreatology 2001;1:423-431.
52.
Whitcomb DC, Pogue-Geile K. Pancreatitis as a risk for pancreatic cancer. Management of
Premalignant Disorders of the Gastrointestinal Tract, JC Reynolds, Guest Ed., Gastroenterology
Clinics of North America 2002:647-661.
53.
Khalid A, Whitcomb DC. The importance of autoimmune pancreatitis. (Selected Summary)
Gastroenterology 2001;Vol.121,(6)1518-1519.
17
54.
Whitcomb DC. Hereditary Pancreatitis: A model for understanding the genetic basis of acute and
chronic pancreatitis. Pancreatology 2001;1:565-570.
55.
Schneider A, Whitcomb DC. Hereditary pancreatitis: a model for inflammatory diseases of the
pancreas. Best Pract Res Clin Gastroenterol 2002;16(3):347-363.
56.
Khalid A, Whitcomb DC. Conservative Treatment of Chronic Pancreatitis. Eur J Gastroenterol
Hepatol. 2002 Sep;14(9):943-949.
57.
Schneider A, Whitcomb DC, Singer MV. Animal models in alcoholic pancreatitis – what can we
learn? Pancreatology. 2002;2(3):189-203
58.
Orenstein SR, Shalaby TM, Barmada MM, Whitcomb DC. Genetics of Gastroesophageal Reflux
Disease. Pediatr Gastroenterol Nutr. 2002 May;34(5):506-510. Review.
59.
The Genetics Basis of Pancreatic Disorders, Edited by Durie P, Lerch MM, Lowenfels AB,
Maisonneuve P, Ulrich II CD, Whitcomb DC, Published by Karger, Basil Switzerland, 2002.
60.
Schneider A, Pfützer R, Whitcomb DC. Genetics and Pancreatic Disease in Pancreas Section of
Current Opinion in Gastroenterology 2002;Vol 18, (5):545-551.
61.
Whitcomb DC. Hereditary Pancreatitis. Encyclopedia of Gastroenterology. Editor John A.
Williams (in press).
62.
Whitcomb DC. The genetics of Shwachman-Diamond Syndrome. Gastroenterology 2003
Nov;125(5):1541-1543.
63.
Khalid A, Whitcomb DC. The premalignant lesions for pancreatic cancer: will Pan-in’s pan out?.
(Selected Summary) Gastroenterology 2002;123(2):645-647.
64.
Whitcomb DC. What is the starting mechanism in acute pancreatitis? Trypsin: Friend or Foe?
Controversies in Pancreatology. Editors: Johan Permert, Margery Herrington, Thomas E Adrian,
2003; 61-67.
65.
Whitcomb DC. Nature or Nurture: The View of the Geneticists. In Controversies in
Pancreatology. Editors: Johan Permert, Margery Herrington, Thomas E Adrian, 2003;16-24.
66.
Whitcomb DC. Motion: Genetic testing is useful in the diagnosis of non-hereditary pancreatic
conditions. Arguments for the Motion. Can J Gastroenterol 2003 Jan;17(1):47-52.
67.
Hanck C, Schneider A, Whitcomb DC. Genetic Polymorphisms in of Alcoholic Pancreatitis. Best
Pract Res Clin Gastroenterol 2003;17(4):613-23.
68.
Oruc N, Whitcomb DC. Theories, mechanisms, and models of alcoholic chronic pancreatitis.
Gastroenterol Clin North Am 2004 Dec;33(4):733-750.
69.
Hanck C, Whitcomb DC. Alcoholic pancreatitis. Gastroenterol Clin North Am 2004 Dec;
33(4):751-765.
70.
Whitcomb DC. The genetic revolution in pancreatic diseases. Can J Gastroenterol (in press)
71.
Whitcomb DC. Genetic Predisposition of Alcoholic Chronic Pancreatitis. Pancreas (in press)
72.
Whitcomb DC. The Genetics of Shwachman Diamond Syndrome (review article).
Gastroenterology 2002;1:881-904.
73.
Whitcomb DC. How to think about SPINK and Pancreatitis. (Editorial). The American Journal of
Gastroenterology. 2002;97(5):1085-8
18
74.
Whitcomb DC. Molecular and genetic mechanisms of acute and chronic pancreatitis. In: M.
Ogawa, T. Yamamoto, M. Hirota, editors. The Biological Response to Planned and Unplanned
Injuries: Cellular, Molecular and Genetic Aspects (2003). Elsevier, Amsterdam. 49-60.
75.
Papachristou GI, Whitcomb DC. “Etiopathogenesis of chronic pancreatitis: A genetic disease with
some precipitating factors?” In: Clinical Pancreatology, Ed J. Enrique Domìnguez-Muňoz,
Blackwell Publishing Ltd., Oxford, England. In Press.
76.
Turner MS, McKolanis JR, Ramanathan RK, Whitcomb DC, Finn OJ. Mucins in gastrointestinal
cancers. Cancer Chemotherapy and Biological Response Modifiers. 2003;21:259-274..
77.
Whitcomb DC. “Risk, Etiology and Pathophysiology of Chronic Pancreatitis”, In: Pancreatitis and
Its Complications, CE Forsmark, editor. (in press)
78.
Whitcomb DC, Somogyi L. Lessons for hereditary pancreatitis. Croatian Medical 2001;42(4):483486.
79.
Turner MS, McKolanis JR, Ramanathan RK, Whitcomb DC, Finn OJ. Mucins in gastrointestinal
cancers. Cancer Chemother Biol Response Modif. 2003; 21:259-274.
80.
Whitcomb DC. Acute Pancreatitis: Molecular Biology Update. J Gastrointest Surg.
2003;7(8):940-942.
81.
Whitcomb DC. Genetic predisposition to alcoholic chronic pancreatitis. Pancreas. 2003;
27(4):321-326.
82.
Miller LJ, Whitcomb DC, Smith JP, Reber HA, Saluja A, Forsmark C, Bell RH Jr, Go VL. Minutes
of the Governing Board of the American Pancreatic Association; Wednesday, November 5, 2003.
Pancreas. 2004 Nov;29(4):324-5.
83.
Papachristou GI, Whitcomb DC. Predictors of severity and necrosis in acute pancreatitis.
Gastroenterol. Clin. North Am. 2004 Dec;33(4):871-90.
84.
Oruc N, DC Whitcomb. Theories, mechanisms and models of alcoholic chronic pancreatitis.
Gastroenterol Clin N Am. 2004 Dec;33(4):733-50.
85.
Hanck C, DC Whitcomb. Alcoholic pancreatitis. Gastroenterol Clin N Am 2004 Dec;33(4):751-65
86.
Papachristou GI, Whitcomb DC. Inflammatory markers of disease severity in acute pancreatitis.
Clinics in Laboratory Medicine 2005;25(1):17-37.
87.
Whitcomb DC. APA Presidential Address: 2004. Pancreas 2005 Aug;31(2):105-107.
88.
Whitcomb DC. Gene mutations as a cause of chronic pancreatitis. In: Ammann RW, Buchler
MW, Adler G, DiMagno EP, Sarner M, editors. Pancreatitis: Advances in pathobiology, diagnosis
and treatment. Dordrecht, The Netherlands: Springer; 2005. p.139-152.
89.
Whitcomb DC. Genetic Testing for Pancreatitis. US Gastroenterology Review 2006. 56-58.
90.
Lerch MM, Griesbacher T, Whitcomb DC. 5th International Symposium on Inherited Diseases of
the Pancreas. Pancreatology 2005;5 Suppl 1:103-10.
91.
Whitcomb DC, Sepulveda AR. Molecular and genetic aspects of gastrointestinal and pancreatic
disease. Clin Lab Med 2005 Mar;25(1):xi-xii.
92.
Papachristou GI, Whitcomb DC. Inflammatory markers of disease severity in acute pancreatitis.
Clin Lab Med 2005 Mar; 25(1):17-37.
93.
Whitcomb DC. Conference Report: Pittsburgh Pancreasfest 2005. Pancreatology 2005 Dec 16;
6(1-2):138-140.
19
94.
Whitcomb DC, Khalid A, Slivka A, McGrath K, Moser AJ, Bell RH Jr. Conference report for APA
postgraduate course: clinical controversies in pancreatobiliary diseases. Pancreas 2005
Oct;31(3):218-220.
95.
Whitcomb DC. Genetic Polymorphisms in Alcoholic Pancreatitis. Dig. Diseases. 23: 247-254.
2005.
96.
Boggiano MM, Chandler PC, Oswald KD, Rodgers RJ, Blundell JE, Ishii Y, et al. PYY3-36 as an
anti-obesity drug target. Obes Rev 2005 Nov;6(4):307-22.
97.
Whitcomb DC. Polygenetic Traits in Pancreatic Disorders. Endo and Metabolism Clinics of N.
America 35 (2): 255-69, 2006 viii.
98.
Greer JB, Whitcomb DC. Does anticipation exist in familial pancreatic cancer? Nat Clin Pract
Gastroenterol Hepatol 2006;3(7):374-5.
99.
Kandula L, Whitcomb DC, Lowe ME. Genetic issues in pediatric pancreatitis. Curr Gastroenterol
Rep 2006;8(3):248-53
100.
Whitcomb DC, Lowe M. Human Pancreatic Digestive Enzymes. Dig Dis Sci (in press).
101.
Greer JB, Whitcomb DC, Brand RE. Genetic predisposition to pancreatic cancer: A brief review.
Am J Gastroenterol 2007;102:1-5.
102.
Whitcomb DC, Barmada MM. A systems biology approach to genetic studies of pancreatitis and
other complex diseases. Cell Mol Life Sci 2007 Jul;64(14):1763-77. PMID: 17415518
103.
Brand RE, Lerch MM, Rubinstein WS, Neoptolemos JP, Whitcomb DC, Hruban RH, Brentnall TA,
Lynch HT, Canto MI; Participants of the Fourth International Symposium of Inherited Diseases of
the Pancreas. Advances in counseling and surveillance of patients at risk for pancreatic cancer.
Gut. 2007 Oct;56(10):1460-9.
104.
Whitcomb DC. Chronic Pancreatitis is Caused by Gene-Environment Interactions. In:
Proceedings of the 5th Meeting of the Pancreas Club, Cluj Romania 2007.
105.
Raina A, Greer JB, Whitcomb DC. Serology in autoimmune pancreatitis. Minerva Gastroenterol
Dietol 2008 Dec: 54(4):375-87.
106.
Whitcomb DC, Cooper S, Raina A, Yadav D. Chronic pancreatitis: clinical and molecular update.
In: Carey MC, Dite P, Gabryelewicz A, Keim V, Mossner J, eds. Future Perspectives in
Gastroenterology: Falk Symposium 161. Dordrecht, The Netherlands: Springer, 2008:176-86
107.
Greer JB, Whitcomb DC. Inflammation and Pancreatic Cancer: an Evidence-Based Review.
Current Opin Pharmacol 2009;Jul 7:411-418.
108.
Whitcomb DC. Genetic Aspects of Pancreatitis. Annual Review of Medicine. 20010;61: 413-24.
109.
Barmada MM, Whitcomb DC. Chapter 10: Integrative Systems Biology: Implications for the
Understanding of Human Disease. Molecular Pathology: The Molecular Basis of Human Disease.
Philadelphia, PA: Elsevier 2009.
110.
Whitcomb DC. Acute and Chronic Pancreatitis. In: Rakel RE, Bope ET, Kellerman R, eds.
Conn’s Current Therapy 2010. Saunders (an imprint of Elsevier, Inc.), Philadelphia 2010.
111.
Muddana V, Whitcomb DC, Papachristou GI. Current management and novel insights in acute
pancreatitis. Expert Rev Gastroenterol Hepatol 2009 Aug;3(4):435-44.
112.
Whitcomb, DC. The National Pancreas Foundation Fellows Symposium Program 2006-2009,
Conference Report. Pancreas (in press).
20
113.
Yadav D, Whitcomb DC. The role of alcohol and smoking in pancreatitis. Nature Reviews
Gastroenterol and Hepatol 2010 Feb 2. PMID: 20125091.
114.
Papachristou GI, Muddana V, Yadav D, Whitcomb DC. Increased serum creatinine is associated
with pancreatic necrosis in acute pancreatitis. Am J Gastroenterol 2010 Jun;105(6):1451-2 (letter
to the editor).
115.
Evans AC, Papachristou GI, Whitcomb DC. Obesity and the risk of severe acute pancreatitis.
Minerva Gastroenterol Dietol 2010 Jun;56(2):169-79. PMID: 20485254.
116.
Gelrud A, Whitcomb DC. The National Pancreas Foundation fellows symposium program 2006 to
2009. Pancreas 2010 Apr;39(3):415-7. PMID: 20335780.
117.
Whitcomb DC. Genetics and Alcohol: A Lethal Combination in Pancreatic Disease? Alcohol Clin
Exp Res. 2011 Feb 8 PMID: 21303381 (Review article)
118.
Guenther A, Aghdassi A, Muddana V, Rau B, Schulz HU, Mayerle J, Kraft M, Whitcomb DC,
Lerch MM, Weiss FU. Toll-like receptor 4 polymorphisms in German and US patients are not
associated with occurrence or severity of acute pancreatitis. Gut. 2010 Jun 29;58(6):813-9 PMID:
20587548 (letter to the editor)
119.
LaRusch JA, Whitcomb DC. Genetics of Pancreatitis. Current Opinion Gastroenterol. (in press).
(invited review)
120.
Whitcomb DC. Going MAD: Development of a “Matrix Academic Division” to Facilitate Translating
Research to Personalized Medicine. Academic Medicine. (in press)
Published Abstracts (partial listing)
1.
Whitcomb DC, Nishikawara NT, O'Dorisio TM, Cataland S. A new sensitive in vivo polypeptide
hormone receptor assay. Federation Proceedings Vol. 41: 1086, 1982. (presented at the 66th
Annual Meeting of the Federation of American Societies for Experimental Biology, New Orleans,
LA. April 15-23, 1983)
2.
Whitcomb DC, Nishikawara MT, Shetzline MA, Cataland S, O'Dorisio TM. Identification of target
organs for gastric inhibitory polypeptide (GIP) using a new in vivo radioreceptor assay. Clinical Research. Vol 31:741A, 1983. (presented at the American Federation of Clinical Research Midwest
Region (Chicago). November 4, 1983).
3.
Whitcomb DC, Nishikawara MT, Shetzline MA, Cataland S, O'Dorisio TM. Identification of target
organs for gastric inhibitory polypeptide (GIP) using a new in vivo radioreceptor assay. Gastroenterology 86: 1357, 1984. (presented at the 84th Annual American Gastroenterology Association
Meeting (New Orleans) May 21, 1984).
4.
Whitcomb DC, Taylor IL, Vigna SR. Autoradiographic localization of bovine pancreatic polypeptide
(bPP) binding sites in the rat brain. Clinical Research 37(2): 540A, 1989. (presented at the
American Federation of Clinical Research, April 28-May 1, 1989).
5.
Whitcomb DC, Vigna SR, Taylor IL. In vivo binding of pancreatic polypeptide in rat brain: possible
site for feed-back inhibition of vagal-dependent pancreatic secretion.
Gastroenterology 98: 531A, 1990. (presented at the 90th Annual American Gastroenterological
Association Meeting (San Antonio), May 16, 1990).
6.
7.
Whitcomb DC, Vigna SR, Taylor IL. Pancreatic polypeptide receptor in rat brain, suprarenal
ganglia, and adrenals. Digestion 46(S1); 121, 1990. (presented at the 8th International Symposium
on Gastrointestinal Hormones (Timmerdorfer Strand, Baltic Sea, FRG), Sept 7, 1990).
8.
Shetzline MA, Zipf WB, Whitcomb DC, Nishikawara MT. Identification of target tissues for
pancreatic polypeptide using an in vivo radioreceptor assay. Federation Proceedings 1985;44:616.
21
9.
Whitcomb DC, Olson J, Hinkle G, Martin EW. Tissue Distribution of Carcinoembryonic Antigen
Antiserum in Nude Mice with CEA- Producing Tumors: Implications for External Gamma Imaging
and Intraoperative Probes. Surgical Forum 1985.
10.
Whitcomb DC, Nishikawara MT, O'Dorisio TM, Cataland S. Specific binding of insulin to male
reproductive organs in vivo. Program and Abstracts, 64th Annual Meeting of the Endocrine Society.
1982;p 334.
11.
Whitcomb DC, Taylor IL, Vigna SR. Autoradiographic localization and pharmacological
characterization of bovine pancreatic polypeptide (bPP) binding sites in the rat adrenal cortex.
Gastroenterology 1980;88:A543.
12.
EJ Hernandez, Whitcomb DC, Taylor IL. In vivo binding of intravenously infused peptide YY in rat
brain. Gastroenterology 1991;100:A827.
13.
Whitcomb DC, Hernandez EJ, Taylor IL. In vivo binding of circulating porcine peptide YY in rat
tissues. Gastroenterology 1991;100:A675.
14.
Mantyh PW, Labenski ME, Allen CJ, Ghilardi JR, Whitcomb DC, Vigna SR, Vinters HV, Stimson
ER, Dahl CE, Maggio JE. Distribution and characterization of amyloid ß protein deposition in
normal human and Alzheimer’s diseased cerebral cortex using 125-I-ßAP(1-40) as the radioligand.
Soc. Neurosci. Abstr 1991;17 (1):912.
15.
Whitcomb DC, Block GD. Low dose acetaminophen hepatotoxicity is more closely associated with
diminished food intake than chronic ethanol use. Gastroenterology 1992;102 (4):A909.
16.
Whitcomb DC, Curtis JT, Stricker EM, Sved AF. Peptide YY microinjected into the dorsal vagal
complex inhibits centrally stimulated pancreatic secretion. Soc. Neurosci. Abst. 1992;19(1):484A.
17.
Whitcomb DC, Martin SP, Puccio AM, Schraut WH, Lee KW. Identification of Peptide YY (PYY)
binding sites on human myenteric and submucosal ganglia by receptor autoradiography. Fourth
International Wexner Symposium abstracts.
18.
Whitcomb DC, Stricker EM. Capsaicin eliminates CCK-A but not Pancreatic polypeptide (PP) or
peptide YY (PYY) receptors in the dorsal vagal complex (DVC) of the rat. Pancreas 1992;7:762.
19.
Whitcomb DC, Martin SP, Puccio AM, Schraut WH, Lee KW. Identification of peptide YY (PYY)
binding sites on human myenteric and submucosal ganglia by receptor autoradiography.
Gastroenterology 1993;104(4):A600.
20.
Martin SP, Puccio A, Whitcomb DC. Identification of pancreastatin binding sites in the dorsal vagal
complex but not the pancreas of the rat. Gastroenterology 1993;140(4):A321.
21.
Whitcomb DC, Curtis JT, Puccio AM, Striker EM, Sved AF. Ligand-receptor binding and
physiological evidence for a new PYY receptor subtype in the dorsal vagal complex of the rat.
Gastroenterology 1993;104(4):A862.
22.
Whitcomb DC. Identification of PYY receptors in the rat brainstem but not intrapancreatic ganglia.
Pancreas 1993;8(6):A776.
23.
Martin SP, Puccio AM, Schraut WH, Lee KW, Reeve Jr JR, Whitcomb DC. Predominance of PYYY1 receptors on myenteric ganglia and PYY-Y2 receptors on enterocytes of human small intestine:
use of 125I-PYY(1-36) and 125I-PYY(3-36) in receptor autoradiography. Gastroenterology
1994;106(4):A536
24.
Whitcomb DC, Puccio AM, Leifer JM, Finley G, Ehrlich GD, Sved AF. Pancreatic Polypeptide (PP)
and Peptide YY (PYY) mRNA in the brainstem of rats detected by reverse-transcriptase PCR (RTPCR). Soc. Neurosci. Abst. 1994;Vol 20(2):1373
22
25.
Whitcomb DC, Martin SP, Schoen RE, Jho HD. Chronic pancreatitis pain-like syndrome caused by
thoracic disc herniation . Pancreas 1994;9(6):A806.
26.
Puccio AM, Hoffman GE, Whitcomb DC. Pancreatic polypeptide receptors in the rat brain localize to
autonomic control areas of the hypothalamus and brainstem, limbic nuclei and the olfactory system.
Gastroenterology 108(4):A999.
27.
Whitcomb DC, Curtis ET, Huh YB, Spannagel A, Sved AF. The effect of urethane anesthetic on
basal pancreatic secretion in the rat after acute and chronic pancreatic duct cannulation.
Gastroenterology 108(4):A401.
28.
Whitcomb DC, Yin M, Curtis JT, Puccio AM, Reeve J, Sved AF. Centrally mediated pancreatic
secretion is stimulated through the Y1 receptor and inhibited through the Y2 receptor.
Gastroenterology 108(4):A400.
29.
Whitcomb DC. Centrally injected PYY (3-36) inhibits pancreatic secretion and binds to Y2-type
receptors expressed in the NTS. Neurogastroenterology and Motility 1995;7(2):134.
30.
Whitcomb DC, Wong-Chong A, Gates L, Zhang Y, White GJ, Martin SP, Ulrich CD, Preston RA,
Ehrlich GD. Hereditary pancreatitis (HP): exclusion of an association with the
immunohistocompatability groups, immune system modulators, complement system and detoxifying
enzymes on chromosome 6 by genetic linkage analysis. Pancreas 1995;11(4):453.
31.
Huh YB, Guarita DM, Whitcomb DC. Urethane anesthetic predominately affects neurally mediated
pancreatic secretion in the cannulated, surgically recovered rat. Gastroenterology
1996;110(4):A400.
32.
Guarita DR, Huh YB, Wood PG, Whitcomb DC. The magnitude of inhibition of basal pancreatic
secretion by peptide YY (PYY) and PYY 3-36 in the conscious rat diminishes as the peripherally
infused dose increases. Gastroenterology 1996;110 (4):A 393.
33.
Rinaman L, Wood PG, Whitcomb DC. Intravenous pancreatic polypeptide (PP) dose-dependently
activates c-fos expression in vagal motor neurons in rat. Gastroenterology 1996;110 (4):A 1112.
34.
Sossenheimer MJ, Wood PG, Gates L, Martin SP, Ulrich CD, Ehrlich GD, Whitcomb DC. Hereditary
pancreatitis: Clinical characteristics of a large kindred. Gastroenterology 1996;110 (4):A432.
35.
Sugitani A, Reynolds JC, Bauer AJ, Whitcomb DC, Starzl TE, Todo S. Nitric oxide, neuropeptide
and enteroendocrine cell morphology and function are preserved following auto-small bowel
transplantation. Gastroenterology 1996;110 (4):A 765.
36.
Sossenheimer MJ, Aston C, Ehrlich GD, Gates L, Martin S, Ulrich C, Preston R, Whitcomb DC.
Accurate diagnosis of hereditary pancreatitis (HP)and exclusion of HP carriers require genetic
markers.
37.
Whitcomb DC, Hoffman G, Wood PG, Kraykovic RL, Spannagel AW, Guan D, Liddle RA, Reeve Jr
JR, Green GM. Luminal CCK Releasing Factor (LCRF) is a neuropeptide localized to nerves in the
gastrointestinal tract and pancreas. Pancreas 1996;13(4):460.
38.
Lowenfels AB, Maisonneuve P, DiMango EP, Elitsur Y, Gates Jr LK, Perrault J, Whitcomb DC.
Hereditary pancreatitis (HP) and the risk of pancreatic cancer (PCA). Pancreas 1996;13(4):448..
39.
Manocha AP, Martin S, Sherman K, Sossenheimer M, Gates LK, Ulrich C, Whitcomb DC. Ranson’s
criteria as a predictor of severity in patients with aids and acute pancreatitis. Gastroenterology
1997;112(4): A462.
40.
Li HS, Achkar JP, R Kim R, Wood PG, Lee RG, Ehrlich GD, Luketich JD, Whitcomb DC. Altered
gene expression in the metaplastic change to Barrett’s epithelium. Gastroenterology 1997;112(4):
A604.
23
41.
Achkar JP, Li HS, Whitcomb DC, Wood PG, Lee RG, Ehrlich GC, Luketich JD, Kim R. Identification
of differrentially expressed genes in the progression of Barrett’s epithelium to esophageal
adenocarcinoma. Gastroenterology 1997;112(4):A530.
42.
Li HS, Deng X, Wood PG, Guarrita DR, Ehrlich GD, Whitcomb DC. Alcohol ingestion leads to
changes in gene expressing in the pancreas and key secretory control sites in rats.
Gastroenterology 1997;112(4):A457.
43.
Gorry M, Whitcomb DC, Gates Jr LK, Ulrich II DR, Zang Y, Preston R, Ehrlich GD. Hereditary
pancreatitis is associated with multiple mutations in the cationic trypsinogen gene. .
Gastroenterology 1997;112(4):A445.
44.
Gabbaizadeh D, Gates L, Ulrich CD, Sossenheimer M, Gorry M, Zang Y, Preston R, Ehrlich GD,
Whitcomb DC. Clinical features of hereditary pancreatitis in a family with a new genotype. .
Gastroenterology 1997;112(4):A442.
45.
Deng X, Wood PG, Whitcomb DC. Acute administration of ethanol to conscious rats significantly
alters exocrine pancreas volume and protein and depends on the route of administration.
Gastroenterology 1997;112(4):A437.
46.
Bracher GA, Manocha A, Bleau B, Whitcomb DC, DeBanto J, Gates L, Ulrich C, Martin SP.
Pancreatic ascites managed successfully with transpapillary pancreatic stent placement. .
Gastroenterology 1997;112(4):A430.
47.
Ulrich CD, Bell Jr RH, Miller LJ, Whitcomb DC. Human pancreatic adenocarcinomas that
specifically bind [125I]VIP fail to bind ([125I]-Tyr10)rat secretin 27 under similar conditions. Pancreas
Club Abstracts, Washington DC, May 11, 1997.
48.
Seymour NE Spector SA, Andersen DK, Elm MS, Whitcomb DC. Hepatic pancreatic polypeptide
receptors are overexpressed in chronic pancreatitis. Proc 31st Ann Mtg Assn Acad Surg: 1997
49.
Lowenfels AB, Whitcomb DC. Estimating the number of hereditary pancreatitis (HP) cases in the
USA. Pancreas 1997;15 (4):444.
50.
Deng X, Wood PG, Eagon PK, Whitcomb DC. Chronic alcohol ingestion alters neurohormonal
control of the rat pancreas. Pancreas 1997;15 (4):432.
51.
Li HS, Rao J, Thompson BS, Deng XY, Wood PG, Eagon PK, Whitcomb DC. Effect of Ethanol on
Gene Expression of MP/PSTI in Rat Pancreas. Gastroenterology 1998;14(4): A479.
52.
Deng X, Wood PG, Pedroso MRA, Eagon PK, Whitcomb DC. Duodenal ethanol infusion in
conscious rats alters exocrine pancreatic response to neurohormonal stimuli. Gastroenterology
1998;114(4): A452.
53.
Li HS, Rao J, Thompson BS, Deng XY, Wood PG, Eagon PK, Whitcomb DC. Differential
expression of mitochondrial mRNA in pancreas & control sites of ETOH-fed rats. Gastroenterology
1998;114(4):A479.
54.
Whitcomb DC, Wood PG, Miller LJ, Ulrich C. Elucidation of the cellular distribution of secretin
receptors expression in rat pancreas via in situ receptor autoradiography. Gastroenterology
1998;114(4), A2076.
55.
Deng X, Wood PG, Pedroso MRA, Eagon P, Whitcomb DC. Early adaptive changes in
neurohormonal control of the rat exocrine pancreas with 7 days of chronic alcohol ingestion.
Gastroenterology 1998;114(4):A452.
56.
Rossi L, Whitcomb DC, Ehrlich GD, Parvin S, Azad AK, Gyr K. Lack of R117H mutation in the
cationic trypsinogen gene in patients with tropical pancreatitis (TP) from Bangladesh.
Gastroenterology 1998;114 (4);A493.
24
57.
Li HS, Hebda PA, Kelly LA, Whitcomb DC, Dohar JE. Differential gene expression of prostaglandin
receptor EP4 in fetal rabbit wounds of skin and airway.
58.
Whitcomb DC, Applebaum S, Bartness MA, Ford MA, Thompson B, Aston CE, and the Midwest
Multicenter Pancreatic Study Group (MMPSG). Mutations associated with pancreatitis in families in
the United States - The MMPSG Study. Pancreas 1998;17(4):459.
59.
Bartness MA, Duerr RH, Ford MA, Shang L, Barmada MM, Aston CE, Whitcomb DC. A new
hereditary pancreatitis gene may map to chromosome 12. Pancreas 1998;17(4):426.
60.
Gabbaizedah D, Kalff JC, Wood PG, Deng X, Bauer AJ, Whitcomb DC. Association between
pancreatic macrophages, serum amylase and pancreatic edema after the first and second episode
of acute pancreatitis in the rat. Gastroenterology 1999;116(4):A60.
61.
Li HS, Thompson BS, Deng X, Wood PG, Eagon PK, Stolz D, Whitcomb DC. Cloning of the
complete rat mitochondrial ATP synthase subunit 9 gene from the pancreas of alcohol-fed rats.
Gastroenterology 1999;116(4), A1145.
62.
Kopras E, Wo Y, Blumenthal K, Wood P, Lia W, Whitcomb DC, Ulrich C. Cloning, expression and
purification of functional wild-type and N21I human cationic trypsin: Validation of an assay system
that separates the kinetics of enzyme activation and autodigestion. Gastroenterology 1999;116(4),
A1171.
63.
Rosenblatt ML, Whitcomb DC. Development of chronic pancreatitis (CP) in Humans after the first
attack of acute pancreatitis (AP) Is Associated with the Severity of the First Attack of AP.
Gastroenterology 1999;116(4), A1160.
64.
Pedroso MRA, Oliva J, Venkatesan T , Ulrich C, Saul M, Schoen RE, Whitcomb DC. An admission
hematocrit of 40 or less predicts a low risk of pancreatic necrosis and may reduce the need for
diagnostic CT scans. Gastroenterology 1999;116(4), A1176.
65.
Deng X, Wood P, Sved A, Whitcomb DC. The effects peripherally infused pancreatic polypeptide
(PP) and peptide YY (PYY) on pancreatic exocrine function are altered by an area postrema (AP)
lesion. Gastroenterology 1999;116(4), A1117.
66.
DeBanto JR, Pedroso RA, Whitcomb DC, Goday PS, Ulrich CD, Gates LK. Epidemiology of
pediatric acute pancreatitis. Gastroenterology 1999;116(4), A1117.
67.
Whitcomb DC, Bartness M, Barmada MM, Dasouki MJ, Staiano A, Neoptolemos JP, Applebaum
S, Ford M, Zhang L, Duerr RH, Aston CE. A new hereditary pancreatitis gene maps to
chromosome 12p. Digestion 1999; 60:409
68.
Whitcomb DC. High pancreatic juice bicarbonate levels depend on pancreatic anatomy - A
theoretical model. Digestion 1999;60:408.
69.
Lowenfels AB, Maisonneuve P, Whitcomb DC, and the International Hereditary Pancreatitis Study
Group*. Smoking and the risk of pancreatic cancer in patients with hereditary pancreatitis (HP).
JAMA, July 11, 2001;Vol 286, No. 2.
70.
Ford ME, Applebaum SE, O’Connell JA, Whitcomb DC, and the Midwest Multicenter Pancreatic
Study Group (MMPSG). Identification of the Cationic Trypsinogen A8V mutation in the USA.
Pancreas 1999;19(4).
71.
Applebaum SE, Peters JA, Aston CE, Whitcomb DC. Factors influencing the decision to participate
in hereditary pancreatitis research studies and to share genetic tests results. Pancreas 1999;19(4).
72.
Pfüetzer RH, Li H-S, Thompson BS, Ford MA, Eagon PK, Whitcomb DC. Pancreatic cholesterol
esterase mRNA expression is upregulated in vivo during chronic ethanol feeding in rats. Pancreas
1999;19(4):435.
25
73.
Howes N, Keim V, Mossner J, Lerch M, Endres S, Delhaye M, Veerman G, Luccidi V, Charnley R,
Creighton J, Ihse I, Attila O, O’ Donnel M, Greenhalf W, Ellis I, Rutherford S, Mountford R,
Whitcomb DC, Neoptolemos JP. PRSS1 mutations in patients with hereditary pancreatitis in
Europe and their relationship to disease presentation and progress. Surgical Research Society in
London.
74.
Gates LK, Iftikhar R, Fazel A, Nayyar S, Burton FR, DeMeo MT, Conwell DL, DeBanto JR, Pedroso
MR, Goday PS, Whitcomb DC, Ulrich CD. Validation of a severity scoring system for acute
pancreatitis in children. Gastroenterology 2000;Vol. 118(4):A916.
75.
Farrell C, Sebastian SS, Applebaum SE, O’Connell JA, Whitcomb DC, O’Donnell LD. The R117H
Cationic trypsinogen gene mutation is identified in a large kindred with hereditary pancreatitis in the
west of Ireland. Gastroenterology 2000:Vol. 118(4);A5273.
76.
Khalid A, Thompson B, Finkelstein S, Godfrey A, Whitcomb DC. Relative allelic expression in
hereditary pancreatitis. Pancreas.
77.
Howes N, Lerch M, Mossner J, Endres S, Deviere J, Veereman G, Lucidi V, Charnley R, Imrie C,
Olah A, Ihse I, Steenbergan W, O’Donnell M, Greenhalf W, Ellis I, Rutherford S, Mountford R,
Whitcomb DC, Neoptolemos JP. High risk of surgical intervention in hereditary pancreatitis. British
Journal of Surgery 2001;88:475-478.
78.
Khalid A, Thompson BS, Whitcomb DC. Non-penetrance of the hereditary pancreatitis (HP)
phenotype in a patient with the R122H mutation: the role of pancreatic secretory trypsin inhibitor
(SPINK1/PSTI). Gastroenterology 2001.
79.
Li HS, Zhang J, Deng X, Thompson BS, Wood PG, Eagon PK, Whitcomb DC. Altered pancreatic
gene expression in alcohol fed rats using microarray analysis of stress and detoxification genes.
Gastroenterology 2001;120;5:168.
80.
Pfŭetzer RH, Myers ER, Shapiro SE, Finch R, Ellis I, Kant JA, Neoptolemos JP, Whitcomb DC.
Novel cationic trypsinogen (PRSS1) mutations N29T and R122C confer autosomal dominant
hereditary pancreatitis. Gastroenterology 2001;120;5:170.
81.
Pfŭetzer RH, Finch R, Shapiro SE, Barmada MM, Myers ES, Chensny LJ, Whitcomb DC. SPINK1
mutations modify phenotypic expression in hereditary pancreatitis (HP) caused by cationic
trypsinogen (PRSS1) mutations R122H and N291. Gastroenterology 2001;120;5:171.
82.
Orenstein SR, Shalaby TM, Pfŭetzer RH, Barmada MM, Finch R, Kosmack S, Chensny LJ,
Whitcomb DC. Autosomal dominant infant GERD: Exclusion of a 13q14 locus in 5 wellcharacterized families. Gastroenterology 2001;120;5:1109.
83.
Pfŭetzer RH, Tadic SD, Li HS, Thompson BS, Zhang JY, Eagon PK, Whitcomb DC. Cholesterol
esterase (CEL), pl 6.1 esterase (ES-10) and fatty acid ethyl ester synthase III (FAEES) gene
expression are increased in pancreas and liver, but not in brain or heart, of rats chronically fed
ethanol. Gastroenterology 2001;120;5:2738.
84.
Suman A, Schneider A, Rossi L, Barmada M, Parvin S, Ali L, Azad Khan AK, Gyr N, Whitcomb DC.
SPINK1 mutations in tropical pancreatitis and diabetes patients from Bangladesh. Pancreas 2001;
23;4:462.
85.
Threadgold J, Ellis I, Howes N, Lerch MM, Charnley R, Laugier R, Frulloni L, Attila GO, Delhaye M,
Ihse I, Havelund T, Andrén-Sandberg A, Imrie CW, Martinek J, Gress TM, Mountford R, Whitcomb
DC, Neoptolemos JP, Greenhalf W. The N34S mutation of PSTI (SPINK1) is associated with a
familial pattern of idiopathic chronic pancreatitis but does not cause the disease. Pancreatology
2001;1:552.
86.
Shapiro SE, Pfŭetzer RH, Finch R, Whitcomb DC. Family history alone cannot predict the likelihood
of detecting mutations in the cationic trypsinogen gene. Pancreatology 2001;1:554.
26
87.
Pfŭetzer RH, Rossi L, Parvin S, Ali L, Sattar S, Kahn A, Gyr N, Whitcomb DC. SPINK1/PSTI
mutations are associated with tropical pancreatitis in Bangladesh. Pancreatology 2001;1:555.
88.
Pogue-Geile K, Mackey J, Lee K, Moser AJ, Wood PG, Whitcomb DC. Development of a pancreas
gene enriched array – PittPEAR: Early progress and testing. Gastroenterology 2002.
89.
Deng, X, Zhang J, Diorio GJ, Elm MS, Eagon PK, Whitcomb DC. Effect of chronic alcohol
consumption on the inflammatory response to cerulean in rats. Gastroenterology 2002.
90.
Lopez-Talavera JC, Mearin F, Shakil O, Whitcomb DC. Gastric or duodenal distention may not be a
risk factor for bleeding or re-bleeding from variceal hemorrhage in portal hypertension.
Gastroenterology 2002.
91.
Khalid A, Demetris AJ, Whitcomb DC, Sasatomi E, Swalsky P, Finkelstein S. Genetic abnormalities
in an acinar cell tumor of the pancreas. The role of EUS guided FNA cytology and microdissection
based mutational genotyping. Gastroenterology 2002.
92.
Schneider A, Pogue-Geile K, Myers-Fong E, Thompson BS, Suman A, Whitcomb DC. Genetic
screening of the human tumor necrosis factor 1 (TNFR1) in patients with familial chronic
pancreatitis. Gastroenterology 2002.
93.
Schneider A, Barmada MM, Myers-Fong E, Thompson BS, Whitcomb DC. Genetic screening of the
glutathione S-Transferase M3 gene (GSTM3) and the microsomal glutathione S-transferase 1 gene
(MGST1) in patients with familial and alcoholic chronic pancreatitis. Gastroenterology 2002.
94.
Pfŭtzer RH, Eberle MA, Pogue-Geile KL, Bronner MP, Crispin D, Kimmey MB, Duerr RH, Kruglyak
L, Whitcomb DC. Gastroenterology 2002.
95.
Schneider A, Pfutzer RH, Barmada MM, Hepp L, Whitcomb DC. SPINK1PSTI gene mutations in
patients with alcoholic chronic pancreatitis from North America. Gastroenterology 2002.
96.
Khalid A, Sasatomi E, Swalsky P, Whitcomb DC, Finkelstein S. Accuracy of endoscopic brush
cytology of biliary strictures is improved by microdissection based genotyping. Gastroenterology
2003.
97.
Schneider A, Lawrence EC, Barmada MM, Norris JM, Hamman RF, Marshall JA, Ferrell RE,
Whitcomb DC. The SPINK1 N34S mutation is not associated with type 2 diabetes mellitus in the
United States. Gastroenterology 2003.
98.
Schneider A, Barmada MM, Whitcomb DC. SPINK1 mutations are associated with an earlier age at
onset in patients with idiopathic chronic pancreatitis. Gastroenterology 2003.
99.
Hanck CB, Whitcomb DC. Genetic analysis of the interferon-gamma receptor 1 gene in patients
with chronic pancreatitis. Gastroenterology 2003.
100. Deng X, Wang L, Elm MS, Otterbein LE, Choi AMK, Eagon PK, Whitcomb DC. Carbon monoxide
potentiates cerulein-induced pancreatitis in chronic alcohol-fed rats. Gastroenterology 2003.
101. Pogue-Geile K, George R, Crispin D, Brentnall T, Lyons-Weiler J, Whitcomb DC. Marker
Development for Early Detection of Pancreatic Cancer. Gastroenterology 2004.
102. Papachristou G, Malehorn DE, Avula H, Lamb J, Slivka A, Bigbee WL, Whitcomb DC. Serum
Proteomic Pattern as a Predictor of Severity in Acute Pancreatitis. Gastroenterology 2004; 126
(Suppl 2):A-29.
103. Schneider A, Slivka A, Brand R, Cotton P, Hawes R, George R, Lamb J, Barmada MM, Whitcomb
DC. Early Onset Idiopathic Chronic Pancreatitis is a CFTR X SPINK1 Mutations-Associated
Polygeic Disorder. Gastroenterology 2004.
104. Papachristou G, Oruc N, Charlton G, George R, Lamb J, Slivka A, Whitcomb DC. Association of
PAR-2 SNPS with Familial and Sporadic Pancreatitis. Gastroenterology 2004; 126 (Suppl 2):A-593.
27
105. Oruc N, Papachristou GI, Lamb J, Charlton G, Slivka A, Whitcomb DC. Protease Activated
Receptor-4 (PAR-4) Polymorphism in Familial and Sporadic Chronic Pancreatitis. Gastroenterology
2004; 126 (Suppl 2):A-593-4..
106. Whitcomb DC, Ermentrout B. Mathematical Modeling of Bicarbonate Conductance-Disrupting
CFTR Mutations in Pancreatic Duct Cells Predict Inhibition of Pancreatic Fluid Secretion.
Gastroenterology 2004.
107. Papachristou GI, Sass DA, Avula H, Lamb J, Cuneo T, Lokshin K, Barmada MM, Slivka A,
Whitcomb DC. The MCP-1 -2518 G Allele acts as a potent disease severity modifier in acute
pancreatitis. Pancreas 2004; 29:331.
108. Whitcomb, DC. Diagnosis and Classification of Chronic Pancreatitis and TIGAR-O.V2.
Pancreatology 2004; Vol 4(3-4):256.
109. Khalid A, Finkelstein S, Brody D, Swalsky P, Moser AJ, Lee KK, Slivka A, Whitcomb DC, Mcgrath K.
Comparison of EUS guided pancreatic cyst (PC) aspirate Cea, DNA quantity: Mutational acquisition
pattern in predicting malignancy. Gastrointestinal Endoscopy, 2005 61(5), AB287.
110. Papachristou GI, Papachristou DJ, Avula H, Slivka A, Whitcomb DC. “Obesity increases the
severity of acute pancreatitis: performance of APACHE-O score and correlation with the
inflammatory response” American Journal of Gastroenterology 2005; 100(9): S73.
111. Papachristou GI, Papachristou DJ, Morinville VD, Slivka A, Whitcomb DC. “Chronic alcohol
consumption is a risk factor for pancreatic necrosis in acute pancreatitis” Pancreas 2005; 31:462.
112. Bhat YM, Papachristou GI, Lamb J, Slivka A, Whitcomb DC. “Polymorphisms of the GSTT-1*A
gene do not predict severity of acute pancreatitis in the US population” Pancreas 2005; 31:433434.
113. Whitcomb, DC, Oruc N, Lamb J, Greer JB, Ding X, Barmada MM. Gene-environment facators that
contribute to alcoholic pancreatitis in humans. Digestive Disease Week, May 22, 2006.
114. Khalid A, Nodit L, Raab S, Ahmad J, Brody D, Bauer K, McGrath K, Whitcomb D, Slivka A,
Finkelstein S. Endoscopic biliary brush microsatellite loss analysis in primary sclerosing cholangitis
and associated cholangiocarcinoma. 2006, DDW, W1440.
115. Muddana V, Lamb J, Wlinoff B, Fink E, Brand R, Hawes RH, Cotton PB, Slivka A, Whitcomb DC.
Prevalence of the calcium sensing receptor gene (CSAR) 518T. Polymorphism in patients with
idiopathic pancreatitis in the United States. 2006, ACG, poster abstract 845.
116. Muddana V, Lamb J, Elinoff B, Fink E, Brand R, Hawes RH, Cotton PB, Slivka A, Whitcomb DC.
Prevalence of the calcium sensing receptor gene (CSAR) 518T>C polymorphism in patients with
idiopathic pancreatitis in the United States. 2006 Volume 101 (9), 180.
117. Raina A, Lamb J, Fink EN, Urda SJ, Moser AJ, Zeh H, Slivka A, Whitcomb DC. The utility of
screening for autoimmune pancreatitis using elevated levels of IgG4 in consecutive patients
diagnosed with pancreatitis or pancreatic cancer. 2006, ACG, poster abstract 452.
118. Sass DA, Papachristou GI, Cuneo T, Lamb J, Berk BS, Whitcomb DC. “The "A-2518G" Monocyte
Chemotactic Protein-1 Gene Polymorphism Is Not Associated with Primary Biliary Cirrhosis”
American Journal of Gastroenterology 2006; 101(9): AB358.
119. Aoun E, Lamb J, Papachristou GI, Oruc N, Barmada MM, Whitcomb DC. “Prevalence of the N34S
Mutation in Patients with Acute Pancreatitis” American Journal of Gastroenterology 2006; 101(9):
AB201.
28
120. Aoun E, Chang CC, Papachristou GI, Oruc N, Barmada MM, Whitcomb DC. “Variation in SPINK-1
N34S Effect Size Is Population-Dependant” American Journal of Gastroenterology 2006; 101(9):
AB209
121. Muddana V, Lamb J, Elinoff B, Fink E, Brand RE, Hawes RH, Cotton PB, Slivka A, Whitcomb DC.
Prevalence of the calcium sensing receptor gene (CaSR) 518T>C polymorphism in patients with
idiopathic pancreatitis in the United States. Poster presented at: American College of
Gastroenterology, 2006; Las Vegas, NV.
122. Lamb J; Krasinskas AM; Fink E; Moser AJ; Zeh H; Slivka A; Whitcomb DC Chronic Pancreatitis Serum IgG4 levels in acute recurrent pancreatitis, chronic pancreatitis and pancreatic cancer in the
USA, Poster presentation, Washington, DC, Digestive Disorders Week, 5/21/07
123. Sharma A; Lamb J; Corrado K; Kandula L; Lowe ME; Avula H; Slivka A; Barmada MM; Whitcomb
DC; Papachristou GI Clinical Acute Pancreatitis - TNF-α polymorphisms increase the risk of acute
pancreatitis. Poster presentation, Washington, DC, Digestive Disorders Week, 5/22/07.
124. Aoun E, Slivka A, Papachristou DJ, Gleeson FC, Whitcomb DC, Papachristou GI. “Rapid Evolution
from the first episode of Acute Pancreatitis to Chronic Pancreatitis in human subjects” American
Journal of Gastroenterology 2007; 102(9): AB209.
125. Muddana V, Barmada MM, Lamb J, Elinoff B, Hawes RH, Cotton, PB, Anderson M, Brand RE,
Slivka A, Whitcomb DC. Prevalence of the calcium sensing receptor (CaSR) gene polymorphisms in
patients with recurrent acute and chronic pancreatitis with or without SPINK1 N34S. Poster
presented at: American College of Gastroenterology, 2007; Philadelphia, PA.
126. Aoun E, Muddana V, Lamb J, Barmada MM, Papachristou GI, Whitcomb DC. “SPINK1 N34S is not
associated with the sentinel acute pancreatitis”episode but predisposes patients to recurrent
attacks” Gastroenterology 2008; 134 (Suppl 1): A-313.
127. Muddana V, Sharma A, Lamb J, Slivka A, Whitcomb DC, Papachristou GI. “The IL-6 -174 G/G
genotype increases susceptibility to acute pancreatitis (AP) in obese subjects” Gastroenterology
2008; 134 (Suppl 1): A-314.
128. Papachristou GI, Muddana V, Corrado K, O’Connell M, Slivka A, Whitcomb DC. “Epidermal Growth
Factor +61 G/A polymorphism and serum levels in patients with Acute Pancreatitis”
Gastroenterology 2008; 134 (Suppl 1): A-314.
129. Sharma A, Muddana V, Lamb J, Slivka A, Whitcomb DC, Papachristou GI. “Visfatin polymorphisms
and elevated BMI interact to increase the susceptibility to acute pancreatitis” Gastroenterology 2008;
134 (Suppl 1): A-314.
130. Chen JS, Aoun E, Gleeson FC, Whitcomb DC, Papachristou GI. “A Meta-analysis of Interleukin-6
and Interleukin-8 as Early Markers of Severe Acute Pancreatitis” Gastroenterology 2008; 134 (Suppl
1): A-371.
131. Muddana V, Whitcomb DC, Khalid A, Slivka A, Papachristou GI. “Elevated Serum Creatinine as a
Marker of Pancreatic Necrosis in Acute Pancreatitis” American Journal of Gastroenterology 2008;
103(S1): S74.
132. Sharma A, Muddana V, Lamb J, Whitcomb DC, Papachristou GI. “Adiponectin Polymorphisms and
Serum Adiponectin Levels in Severe Acute Pancreatitis” American Journal of Gastroenterology
2008; 103(S1): S73.
133. Whitcomb DC, Muddana V, Langmead CJ, Lamb J, Papachristou GI. “Angiopoietin-2, a regulator of
vascular permeability in inflammation is elevated in severe acute pancreatitis and is associated with
systemic organ failure” Pancreas 2008; 37(4): 500.
134. Yadav D, Whitcomb DC, Lowenfels AB, NAPS2 consortium, Slivka A, Hawes RH, Brand R,
Anderson MA, Money ME, Banks PA, bishop MD, Baillie J, Sherman S, DiSario JA. How does
29
patient’s self-reported alcohol use compare with physician’s assessment in chronic pancreatitis
(CP)? Poster Presentation, San Diego, CA, Digestive Disorders Week, 5/18/08.
135. Yadav D, Barmada MM, Bishop MD, O’Connell MR, Whitcomb DC, NAPS2 consortium, Slivka A,
Hawes RH, Brand R, Anderson MA, Banks PA, Baillie J, Sherman S, DiSario JA. Alcohol and
smoking are independent predictors for chronic pancreatitis. Poster Presentation, San Diego, CA,
Digestive Disorders Week, 5/18/8.
136. Yadav D, Banks PA, Slivka A, Whitcomb DC, NAPS2 consortium. Current profile of chronic
pancreatitis (CP) in the USA: Is it a multifactorial disease? Poster Presentation, San Diego, CA,
Digestive Disorders Week, 5/18/8.
137. Papachristou GI, Muddana V, Corrado K, O’Connell MR, Slivka A, Whitcomb DC. Epiderman
growth factor +61 G/A polymorphism and serum levels in patients with acute pancreatitis. Poster
Presentation, San Diego, CA, Digestive Disorders Week, 5/18/008.
138. Sharma A, Muddana V, Lamb J, Slivka A, Whitcomb DC, Papachristou GI. Visfatin polymorphisms
and elevated BMI interact to increase the susceptibility to acute pancreatitis. Poster Presentation,
San Diego, CA, Digestive Disorders Week, 5/18/8.
139. Muddana V, Sharma A, Lamb J, Slivka A, Whitcomb DC, Papachristou GI. The IL-6-174 G/G
genotype increases susceptibility to acure pancreatitis (AP) in obese subjects. Poster Presentation,
San Diego, CA, Digestive Disorders Week, 5/18/8.
140. Papachristou GI, Muddana V, Corrado K, O’Connell MR, Slivka A, and Whitcomb DC. Epidermal
growth factor +61 G/A polymorphism and serum levels in patients with acute pancreatitis. AGA
abstract, Am. J of Gastro, S2093;A-314, 2008.
141. Sharma A, Muddana V, Lamb J, Slivka A, Whitcomb DC and Papachristou GI. Visfatin
polymorphisms and elevated BMI interact to increase the susceptibility to acute pancreatitis. AGA
abstract, Am. J of Gastro;S2094, A-314, 2008.
142. Muddana V, Sharma A, Lamb J, Slivka A, Whitcomb DC, and Papachristou GI. The IL-6-I74 G/G
genotype increases susceptibility to acute pancreatitis (AP) in obese subjects. AGA abstract, Am. J
of Gastro; S2095, A-314, 2008.
143. Yadav R, Banks PA, Slivka A, Whitcomb DC and NAPS2 consortium. Current profile of chronic
pancreatitis (CP) in the USA: Is it a multifactorial disease? AGA abstract, Am. J of Gastro;S1331,
A-228, 2008.
144. Yadav D, Barmada MM, Bishop MD, O’Connell MR, Whitcomb DC, NAPS2 consortium, Slivka A,
Hawes RH, Brand R, Anderson MA, Banks PA, Baillie J, Sherman S, DiSario A, Gelrud A, Lo SK,
DeMeo m, Steinberg W, Kochman ML, Etemad B, and Forsmark C. Alcohol and smoking are
independent predictors for chronic pancreatitis. AGA abstract, Am. J of Gastro;S1324, A-226, 2008.
145. Yadav D, Whitcomb DC, Lowenfels AB, NAPS2 consortium, Slivka A, Hawes RH, Brand R,
Anderson MA, Money ME, Banks PA, Bishop MD, Ballie J, Sherman S, DiSario JA, Burton FR,
Gardner TB, Amann ST, Gelrud A, Lo SK, DeMeo MT, Steinberg W, Koshman ML, Etemad B,
Forsmark C. How does self-reported alcohol use compare with physician’s assessment in chronic
pancreatitis (CP)? AGA abstract, Am. J of Gastro;S1318, A-225, 2008.
146. Mullady DK, Whitcomb DC, Yadav D, Barmada MM, O’Connell MR, Korneffel ML, Weinman BM,
Amann ST, Anderson MA, Slivka A, Hawes RH, Brand R, Money ME, Banks PA, Gardner TB,
Gelrud A, Lo SK, DeMeo MT, Steinberg W, and Kochman ML. Chronic pancreatitis characterized
by constant pain regardless of severity is associated with poorer quality of life, lower functioning and
increased utilization of resources. AGA abstract, Am. J of Gastro, S1314, A-224, 2008.
147. Muddana V, Whitcomb DC, Khalid V, Slivka A, Papachristou GI. Elevated serum creatinine as a
marker of pancreatic necrosis in acute pancreatitis. Poster presentation at: American College of
Gastroenterology, 2008; Orlando, FL.
30
148. Muddana V, Sharma A, Lamb J, Slivka A, Whitcomb DC, Georgios I. Papachristou. The IL-6 -174
G/G genotype increases susceptibility to acute pancreatitis (AP) in obese subjects. Poster
presentation at: Digestive Diseases Week, 2008; San Diego, CA
149. Whitcomb DC, Muddana V, Langmead CJ, Lamb J, Papachristou GI. Angiopoietin-2, a regulator of
vascular permeability in inflammation is elevated in severe acute pancreatitis and is associated with
systemic organ failure. American Pancreas Association, 2008, Chicago, IL.
150. Sharma A, Muddana V, Lamb J, Whitcomb DC, Papachristou GI. Adiponectin polymorphisms and
their role in acute pancreatitis. Poster presentation at: American College of Gastroenterology, 2008;
Orlando, FL.
151. Sharma A, Muddana V, Lamb J, Whitcomb DC, Papachristou GI. Visfatin polymorphisms and
elevated BMI interact to increase the susceptibility to acute pancreatitis. Poster presentation at:
Digestive Diseases Week, 2008; San Diego, CA
152. Papachristou GI, Muddana V, Corrado K, O'Connell MR, Slivka A, Whitcomb DC. Epidermal Growth
Factor +61 G/A Polymorphism and serum levels in patients with acute pancreatitis. Poster
presentation at: Digestive Diseases Week, 2008; San Diego, CA
153. Aoun E, Muddana V, Lamb J, Barmada MM, Papachristou GI, Whitcomb DC. SPINK1 N34S is not
associated with the sentinel acute pancreatitis episode but predisposes patients to recurrent
attacks. Poster presentation at: Digestive Diseases Week, 2008; San Diego, CA
154. Muddana V, Chakraborty S, Whitcomb DC, Brand R, Papachristou GI, Batra SK. “Serum
Neutrophil-associated Gelatinase Lipocalcin (NGAL) levels as an early biomarker of severe acute
pancreatitis” Gastroenterology 2009; 136: A-543.
155. Papachristou GI, Muddana V, Langmead CJ, Clermont G, Whitcomb DC. “Multiplex Serum Marker
Panel Accurately Predicts Systemic Complications of Acute Pancreatitis” Gastroenterology 2009;
136: A-313.
156. Muddana V, Park J, Lamb J, Papachristou GI, Hawes RH, Brand R, Slivka A, Whitcomb DC
“Platelet Derived Growth Factor Functional Polymorphisms Are Not Associated with Chronic
Pancreatitis” Gastroenterology 2009; 136: A-275.
157. Muddana V, Papachristou GI, Yadav D, Sanders MK, Slivka A, Whitcomb DC “Comparison of
BISAP, Ranson’s, APACHE-II and CTSI scores in predicting severity, complications and mortality in
acute pancreatitis” American Journal of Gastroenterology 2009; 104(S3): S73.
158. Aoun E, Chen JS, Whitcomb DC, Papachristou GI. “The Diagnostic Accuracy of Interleukin-6 and 8
in Predicting Severe Acute Pancreatitis: A Meta-Analysis” American Journal of Gastroenterology
2009; 104(S3): S84.
159. Muddana V, Papachristou GI, O’Connell M, Whitcomb DC “Resistin, an Adipokine, is a Potential
Early Biomarker in Predicting Severe Acute Pancreatitis” American Journal of Gastroenterology
2009; 104(S3): S87.
160. Muddana V, Park J, Lamb J, Papachristou GI, Hawes RH, Brand R, Slivka A and Whitcomb DC.
Platelet derived growth factor functional polymorphisms are not associated with chronic
pancreatitis. Poster S1812, Digestive Disorders Week, 5/31/09.
161. Raina A, Yadav D, Krasinskas AM, McGrath K, Khalid A, Sanders MK, Whitcomb DC and Slikva A.
Evaluation and management of autoimmune pancreatitis: Experience at a large US Center. Poster
S1285, Digestive Disorders Week, 5/31/09.
162. Fasanella KE, Krasinskas AM, Schoedel K, Sasatomi E, Meier CB, Slivka A, Sanders MK,
Whitcomb DC, McGrath K, Nodit L, Ohori NP and Khalid A. Pre-operative distinction between
pancreatic cancer and cholangiocarcinoma based on DNA mutational differences in cytological
specimens. Poster M1412, Digestive Disorders Week, 6/1/09.
31
163. Muddana V, Papachristou GI, O’ Connell M, Whitcomb DC. Resistin, An Adipokine, is a potential
early biomarker in predicting severe acute pancreatitis. Oral presentation at: Digestive Disease
Week 2009; New Orleans, LO.
164. Whitcomb DC, Muddana V, Langmead CJ, Houghton FD, Guenther A, Eagon PK, Mayerle J,
Aghdassi A, Weiss FU, Lamb J, Clermont G, Lerch MM, Papachristou GI. Angiopoietin-2, a
Regulator of Vascular Permeability in Inflammation, Is Associated With Persistent Organ Failure in
Patients With Acute Pancreatitis From the United States and Germany. Poster presented at:
Digestive Disease Week 2009. New Orleans, LO.
165. Burton FR, Anderson MA, Muddana V, Alkaade S, Gardner TB, Amann ST, Lewis MD, DiSario JA,
Brand R, Sherman S, Baillie J, Banks PA, Gelrud A, Hawes RH, Kennard E, Slivka A, Yadav D,
Whitcomb DC . Use and Helpfulness of Mechanism-Targeted Medical Pain Therapies in Chronic
Pancreatitis. Poster presented at: Digestive Disease Week 2009. New Orleans, LO.
166. Bishehsari F, Papachristou GI, Muddana V, Sharma A, Whitcomb DC. TNF-α Polymorphisms at 1031 and -863 Are Associated With Multiple Organ Failure in Acute Pancreatitis. Poster presented
at: Digestive Disease Week 2009. New Orleans, LO.
167. Muddana V, Papachristou G, Yadav D, Sanders M, Slivka A, Whitcomb DC. Comparison of BISAP,
Ranson’s, APACHE-II and CTSI scores in predicting organ failure, complications and mortality in
acute pancreatitis. Poster presented at: American College of Gastroenterology 2009; San Diego,
CA.
168.
Muddana V, Park J, Lamb J, Papachristou GI, Hawes RH, Brand RE, Slivka A, Whitcomb DC.
Platelet derived growth factor functional polymorphisms are not associated with chronic pancreatitis.
Poster presented at: Digestive Disease Week 2009; Chicago, IL.
169. Muddana V, Papachristou GI, Chakrabarthy S, Kaur S, Sharma N, Whitcomb DC, Brand R, Batra S.
Serum Neutrophil-associated Gelatinase Lipocalcin (NGAL) levels as an early biomarker of severe
acute pancreatitis. Poster presented at: Digestive Disease Week 2009; Chicago, IL.
170. Greer JB, Yazer MH, Raval JS, Barmada MM, Brand RE, Whitcomb DC. Significant association
between ABO blood group and pancreatic cancer. IBST Conference 10 (International Society of
Blood Transfusion), Berlin, Germany. July 23-30, 2010.
171. Bishehsari F, Papachristou GI, Muddana V, Sharma A, Whitcomb DC “TNF-α Polymorphisms at
−1031 and −863 are Associated With Multiple Organ Failure in Acute Pancreatitis” Gastroenterology
2010; 138: S-435.
172. Muddana V, Evans AC, Langmead CJ, Clermont C, Barmada MM, Papachristou GI, Whitcomb DC
“Resistin, a Potent Adipokine, is Associated With Acute Pancreatitis: Assessment of Functional
Genetic Polymorphisms and Serum Levels” Gastroenterology 2010; 138: S-66.
173. Whitcomb DC, Muddana V, Langmead CJ, Houghton FD, Guenther A, Eagon PK, Mayerle J,
Aghdassi A, Weiss FU, Lamb J, Clermont G, Lerch MM, Papachristou GI
“Angiopoietin-2, a Regulator of Vascular Permeability in Inflammation, is Associated With Persistent
Organ Failure in Patients With Acute Pancreatitis From the United States and Germany”
Gastroenterology 2010; 138: S-238.
PROFESSIONAL ACTIVITIES
TEACHING:
1.
Teaching assistant- Ohio State University, Department of Physiology 1978-1983
2.
Programs in Physiology - Computer Assisted Instruction Programs, Ohio State University 19821983
32
3.
GI Lecture series - Course Coordinator, Duke University, Division of Gastroenterology, 1988-1991
4.
Diseases of the Pancreas, (2nd year medical school course) January 1992
5.
Gastroenterology laboratory (2nd year medical school course) , January 1992
6.
Pancreatic Physiology (2nd year medical school course) 1993, 1994, 1995, 1996, 1997, 1998
7.
Acute and Chronic Pancreatitis. (2nd year medical school course) 1993, 1994, 1995, 1996, 1997,
1998, 1999
8.
Digestion and Absorption (2nd year medical school course) 1995, 1996, 1997
9.
Problem-based learning sessions (multiple topics) (2nd year medical school course) 1994, 1995,
1996, 1997, 1998, 1999
7.
Physical Diagnosis (second year medical students), February-March 1993
8.
Pancreatic Physiology. Gastroenterology Section of the Doctor of Pharmacy Programs' Advanced
Pharmacotherapy course, School of Pharmacy. January 31, 1995
9.
Molecular and Human Genetics - Problem solving session on gene mapping and linkage analysis
(1st year medical school), 1997
10.
Pathology Graduate Course. The Exocrine Pancreas. Molecular mechanisms of tissue growth and
differentiation. February 25, 2000.
INVITED PRESENTATION, CME / Visiting Professor / Review Courses:
1.
"Receptor based approach to pancreatic polypeptide physiology," Department of Physiology,
University of Pittsburgh, Oct. 1991.
2.
"Receptor based approach to pancreatic polypeptide physiology," Department of Gastroenterology,
Children's Hospital, Pittsburgh, PA, Jan. 1992.
3.
"Where does peptide YY act to inhibit pancreatic secretion, " Division of Gastroenterology,
University of Pittsburgh, Jan. 1992.
4.
"Non-Cardiac Chest Pain," Armstrong County Memorial Hospital, Feb. 1992.
5.
"Capsaicin eliminates CCK-A but not pancreatic polypeptide or peptide YY receptors in the dorsal
vagal complex of the rat". HSA GI Research Conference, Plymouth Meeting, PA. June 18, 1992.
6.
"Chronic Pancreatitis" Hershey Medical Center Grand Rounds. Hershey, PA, June 24, 1992.
7.
"Treatment for Pancreatic Exocrine Insufficiency" McKeesport Hospital General Weekly Update,
McKeesport, PA July 15, 1992.
8.
"Pancreatitis", State-of-the-Art Lecture, Division of Gastroenterology and Hepatology, University of
Pittsburgh Medical Center, July 30, 1992.
9.
"Advancements in Therapy of Chronic Pancreatitis" Kanawha Valley Family Practice Center Grand
Rounds, So. Charleston, West Virginia, August 4, 1992.
10.
Advances in the Treatment of Chronic Pancreatitis. Medical Residents Noon Conference, Oakland
Veterans Administration Medical Center, Oakland, PA August 17, 1992.
11.
Update on Chronic Pancreatitis. Medical Residents Noon Conference, Montefiore Medical Center,
Pittsburgh, PA August 20, 1992.
33
12.
"Chronic Pancreatitis" Veterans Administration Medical Center, Fort Wayne, IN, August 21, 1992.
13.
"Pancreatic Exocrine Insufficiency" Medical Grand Rounds, Raritan Bay Medical Center, Perth
Amboy, NJ, September 29, 1992.
14.
"Chronic Pancreatitis". Veterans Administration Medical Center, Bath, NY, October 2, 1992.
15.
"Chronic Pancreatitis" Pancreatic Research Symposium, Hershey Medical Center, Hershey, PA
October 3, 1992.
16.
"Chronic Pancreatitis: A Clinical Update" Divine Providence Hospital Meeting, Pittsburgh PA.
October 13, 1992.
17.
"Diagnosis and Treatment of Chronic Pancreatitis". Update in the Treatment of Digestive
Disorders" University of Pittsburgh Medical Center, Pittsburgh, PA, October 17, 1992.
18.
"Advancements in Therapy of Chronic Pancreatitis" , Sharon General Hospital Staff Meeting,
Sharon, PA January 18, 1993.
19.
"Chronic Pancreatitis: A Clinical Update" Southern Tier Surgical Meeting, Olean, NY. March 27,
1993.
20.
"Chronic Pancreatitis" Ohio Valley Medical Center Grand Rounds, Wheeling WV. April 14, 1993.
21.
"Acetaminophen Hepatotoxicity", University of Pittsburgh Gastroenterology Grand Rounds, June 3,
1993.
22.
"Pancreatitis", Medical Grand Rounds, The Medical Center, Beaver, PA. July 9, 1993.
23.
"Acetaminophen Hepatotoxicity", University of Pittsburgh Medical Grand Rounds, June 10, 1994.
24.
"Chronic Pancreatitis", Willis-Knighton Medical Center, Medical Grand Rounds, Shreveport,
Louisiana, July 12, 1994.
25.
"A New Twist in the Brain-Gut Axis" Endocrine Grand Rounds, University of Pittsburgh Medical
Center, August 26, 1994.
26.
"Acetaminophen Hepatotoxicity" Pittsburgh Gut Club, Pittsburgh, PA, November 7, 1994.
27.
"Pancreatitis" Medical Grand Rounds, St. Francis Medical Center, Pittsburgh, PA Feb., 22, 1995.
28.
"Neural-hormonal control of the pancreas" Gastroenterology and Hepatology Research
Conference, University of Pittsburgh, Pittsburgh, PA . Feb. 23, 1995.
29.
"Dyspepsia". Medical Grand Rounds, Altoona VA Medical Center, Altoona, PA April 5, 1995.
30.
"Acute Pancreatitis - Recognition and Management" Gastroenterology Research Conference,
University of Pittsburgh Medical Center, August 17, 1995.
31.
"Anatomy and Physiology of the Pancreas" Comprehensive Board Review of Gastroenterology,
The George Washington University. October 10, 1995.
32.
“Pathophysiology of Pancreatitis” GI Grand Rounds (Visiting Professor), University of Texas
Southwestern, Dallas Texas, February 22, 1996.
33.
Epidemiology of Pancreatic and Biliary Cancers” in Frontiers I Gastrointestinal Malignancy: The
Present and the Future”. CME course by the University of Pittsburgh. March 30, 1996.
34.
“An Update in Pancreatic Physiology and Pathophysiology”. Richmond Gut Club, Richmond VA.
April 22, 1996.
34
35.
“Upper GI Motility and GERD” Medical Grand Rounds, Veterans Admin. Medical Center,
Huntington WV, April 24, 1996.
36.
“Chronic Pancreatitis” RMDNJ Gastroenterology Symposium, UMDNJ Robert Wood Johnson
Medical Center, New Brunswick, NJ. April 27, 1996.
37.
“Acute Pancreatitis” Medical Grand Rounds, St. Francis Medical Center, Pittsburgh PA, May 10,
1996.
38.
“Chronic Pancreatitis”, Medical Grand Rounds, Saint Elizabeth Hospital, Elizabeth, NJ. June 13,
1996.
39.
“Anatomy and Physiology of the Pancreas” AGA’s 1996 Fall Postgraduate Course. Chicago IL,
Sept 27, 1996.
40.
“Hereditary Pancreatitis”, Gastroenterology Research Conference, University of Pittsburgh, October
8, 1996.
41
“Advances in Pancreatitis”, Medicine Grand Rounds, Department of Medicine, University of
Pittsburgh Medical Center, November 15, 1996.
42.
“Clinical Features of a Hereditary Pancreatitis in a Family with a New Genotype” Midwest Gut Club,
/ Loyola University, Chicago IL, March 1, 1997.
43.
“Keynote Address” First international Symposium on Hereditary Pancreatitis, Pittsburgh PA April 5,
1997.
44.
Hereditary Pancreatitis. AGA Pancreatic Section Special Symposium, AGA 1997 National Meeting,
Washington DC, May 13, 1997.
45.
“Chronic Pancreatitis” Update in Gastroenterology, Albany Medical College, Sarasota Springs, NY
August 15, 1997.
46.
“Hereditary Pancreatitis” Joyce M Miller Visiting Lectureship, University of Iowa, Iowa City, Iowa.
September 18, 1997.
47.
“The Genetic Revolution in Pancreatic Diseases” Gastroenterology Grand Rounds, University of
Iowa, Iowa City, Iowa, September 18, 1997.
48.
“Management of Pancreatitis”, Fall 1997 Meeting of the Gastroenterology Network, Atlanta, GA
September 20, 1997.
49.
“Anatomy and Physiology of the Pancreas”. George Washington University Gastroenterology
Board Review Course, Washington DC, October 7, 1997.
50.
“Breakthroughs in Acute and Chronic Pancreatitis” The Pittsburgh Gut Club, Pittsburgh PA,
October 20, 1997.
51.
“Hereditary Pancreatitis”, Medicine Grand Rounds, Christ Hospital, Jersey City, New Jersey.
October 22, 1997.
52.
“Hereditary Pancreatitis” Symposium on the Advances in Genetics in Pediatric GI, North American
Society for Pediatric Gastroenterology and Nutrition 11th Annual Meeting, Toronto, Ontario,
Canada, November 1, 1997.
53.
“Neurohormonal Control of Pancreatic Function”, Grand Rounds, University of Cincinnati, Cincinnati
OH, December 3, 1997.
54.
“Hereditary Pancreatitis” , Louisville Gut Club, December 10, 1997.
35
55.
“Hereditary Pancreatitis”, GI Grand Rounds, Visiting Professor, Mayo Clinic, January 12-13, 1998.
56.
“The genetic Revolution in Pancreatic Diseases”, 5th International Conference on Pancreatic and
Biliary Endoscopy. Torrance Memorial Medical Center, Torrance CA, January 25, 1998.
57.
The Genetic Revolution in Pancreatic Diseases”, Medical Grand Rounds, Visiting Professor,
University of Florida at Gainesville, FL. February 13, 1997.
58.
“Hereditary Pancreatitis”, Medical Grand Rounds, Visiting Professor, St. Louis University, St. Louis
MO, February 20, 1998.
59.
“Hereditary Pancreatitis”, Medical Grand Rounds, Visiting Professor, Cleveland Clinic, Cleveland,
OH, March 5, 1998.
60.
“The Genetic Revolution in Pancreatic Diseases” GI Grand Rounds, St. Elizabeth - Tufts
University Medical Center, Boston, MA, May 27, 1998.
61.
“Hereditary Pancreatitis” Medicine Grand Rounds, St. Elizabeth Medical Center, Boston, MA. May
28, 1998.
62.
“Hereditary Pancreatitis and Pancreatic familial cancer”. State of the Art Lecture, British Society of
Gastroenterology, Harrogate International Center, Harrogate, England, 1998.
63.
“The Genetic Revolution in Pancreatic Diseases” GI Grand Rounds, University of Pennsylvania
Medical Center, Philadelphia, PA, 1998.
64.
“Hereditary Pancreatitis - Dramatic New insights into Early Molecular Events” - AGA Postgraduate
course. Digestive Disease Week, New Orleans, LA, May 16, 1998.
65.
“Hereditary Pancreatitis: New Insights” AGA State of the Art Lecture. Digestive Disease Week,
New Orleans, LA, May 19, 1998.
66.
“Chronic Pancreatitis”, GI Research Conference, St. Elizabeth Medical Center, Boston MA, May 27,
1998.
67.
“Hereditary Pancreatitis”, Medical Grand Rounds, St. Elizabeth Medical Center, Boston MA, May
28, 1998.
68.
“The Molecular Revolution in Pancreatic Diseases”, GPI Grand Rounds, Boston Medical Center,
Boston, MA, May 28, 1998.
69.
“Hereditary Pancreatitis”, GI Grand Rounds, Hershey Medical Center, Hershey PA, June 3, 1998.
70.
The Molecular Revolution in Pancreatic Diseases”, GI Grand Rounds, University of Washington,
Seattle WA, June 5, 1998.
71.
“Hereditary Pancreatitis”, State of the Art Lecture, The XXX Meeting of the European Pancreatic
Club, Thessaloniki, Greece, June 11, 1998.
72.
“Familial Pancreatic Cancer”, ESPAC Satellite Symposium, EPC Annual Meeting, Thessaloniki
Greece, June 12, 1998.
73.
“The Molecular Revolution in Pancreatic Diseases”, GI Grand Rounds, University of California at
Los Angeles, June 18, 1998.
74.
“Neurohormonal Control of Pancreatic Secretion”, GI Fellows Research Conference, University of
California at Los Angeles, June 19, 1998.
75.
“The Genetic Revolution in Pancreatic Diseases”, Gastroenterology Grand Rounds, University of
Washington, Seattle, WA, ****
36
76.
“Chronic Pancreatitis Update and New IBD Research”, The Allegheny Club. Pittsburgh PA, Sept. 6,
1998.
77.
“Hereditary Pancreatitis and Pancreatic Carcinoma”, Baltic Pancreatic Meeting on Pancreatic
Carcinoma from Bench to Bedside. University of Rostock, Rostock Germany September 18, 1998.
78.
“Acute Pancreatitis - Mechanism of Cell Injury, Genetics”, Pancreatic Disease- State of the Art and
Future Aspects. Munich Germany, September 18, 1998.
79.
“Pancreatic Anatomy and Physiology”, GWU - Gastroenterology Board Review Course. William
Steinberg Director, Washington DC. October 6, 1998.
80.
“An update on new concepts in the development of pancreatitis”, The 21 annual Gastroenterology
Teaching Day, Wilson Regional Medical Center, Johnson City, NY, October 1998.
81.
“Hereditary Pancreatitis”, Oklahoma City Gut Club, (Sponsored by the Oklahoma Digestive Disease
Foundation), Oklahoma City, OK October, 22, 1998.
82.
“Pancreatitis”, Medicine Grand Rounds, University of Pittsburgh Medical Center, October 23, 1998.
83.
“The genetic revolution in pancreatic diseases”, GI Grand Rounds. Medical College of Virginia,
Richmond VA, Oct. 29, 1998.
84.
“An Update on Chronic Pancreatitis”, GI Grand Rounds, McGuire VA Hospital, Richmond VA.
October 30, 1998.
85.
“Alcoholic Pancreatitis”, Southeastern United States VA Teleconference Program, McGuire VA
Hospital, Richmond, VA. October 30, 1998.
86.
“The genetic revolution in pancreatic diseases”, 15th Annual Post Update in Gastroenterology,
Hepatology and Nutrition, SUNY, Binghamton, NY, October 1998.
87
“Hereditary Pancreatitis and Pancreatic Cancer, Premalignant Lesions of the GI tract Section
Symposium, Fort Lauderdale Marina Marriott - Sponsored by the AGA EGD and Oncology
Sections, February 13, 1999.
88
“Advances in Molecular Gastroenterology”, Medical Grand Rounds, University of Pittsburgh,
February 26, 1999.
89
“An admission hematocrit of 40 or less predicts a low risk of pancreatic necrosis and may reduce
the need for diagnostic CT scans”, Midwest Gut Club, Oklahoma City, OK March 6, 1999.
90
“Cloning of the complete rat mitochondrial ATP synthase subunit 9 gene from the pancreas of
alcohol-fed rats”, Midwest Gut Club, Oklahoma City, OK March 6, 1999.
91
“Molecular insights into the Pathophysiology of Pancreatitis”, Second International Symposium on
inherited Diseases of the Pancreas, Cincinnati, Ohio March 20, 1999.
92
“The genetic revolution in pancreatic diseases”, Medicine Grand Rounds, Medical University of
South Carolina, Charleston, SC. March 23, 1999.
93
“Alcoholic Pancreatitis”, Medicine Research Conference, Medical University of South Carolina,
Charleston, SC. March 23, 1999.
94
“Chronic Alcoholic Pancreatitis - A New Pathophysiologic Paradigm”, Gastroenterology Research
Conference, University of Pittsburgh Division of Gastroenterology and Hepatology, March 30, 1999
95.
“Familial Pancreatitis and Pancreatic Cancer”, Innovations in GI Cancer Control and Management:
Genetics and Pancreatic Cancer. University of Pittsburgh and UPMC Health Care System, May 3,
1999.
37
96.
“Where do we go from here: Molecular Biology? International Congress on Cooperative Clinical
Research with Developing Countries, Basal, Switzerland, August 19-21, 1999.
97.
Pancreatic Physiology - board review course, Washington DC, October 5, 1999.
98.
“Normal Pancreatic Physiology”, invited lecture at the American College of Gastroenterology (ACG)
postgraduate course. Phoenix Arizona, October 17, 1999.
99.
“The genetic revolution in pancreatic diseases”, invited lecture at the American College of
Gastroenterology (ACG) postgraduate course, Phoenix Arizona, October 17, 1999.
100. “Advances in Enzyme Based SNP Discovery and Detection”, Satellite symposium of the 1999
Annual Meeting of the American Society for Human Genetics (ASHG), San Francisco Marriott, San
Francisco California, Oct 21, 1999.
101. “Hereditary Pancreatitis”, Invited lecture in the special symposium “Recent Advances in the
Molecular Genetics of Gastrointestinal and Hepatobiliary Disorders”. 1999 Annual Meeting of the
American Society for Human Genetics (ASHG), Moscone Center, San Francisco California, Oct 21,
1999.
102. “mRNA Expression and Protein Synthesis”, Invited lecture at the “Workshop: Alcohol and the
Pancreas” combined program sponsored by the APA, AGA, ADHF and NIH (NIDDK and NIAAA),
November 6, 1999.
103. “The Molecular Genomics of Pancreatic Diseases”, Visiting Professor, University of Michigan, Ann
Arbor, MI Dec 6, 1999.
104. “The Genetic Revolution Pancreatic Diseases”, Memphis Gut Club, Memphis TN, December 7,
1999.
105. “The Molecular Genomics of Pancreatic Diseases”, Visiting Professor, University of Tennessee,
Memphis TN, December 8, 1999.
106. “The Genetic Revolution in Pancreatic Diseases”, Guest Faculty, Columbia-Presbyterian Medical
Center, 15th Annual Postgraduate Medicine Course, New York, NY, December 11-12, 1999.
107. “The Pancreas of the 1990’s: A decade discovering that what we Know, ain’t so”, Physiology
research – Seminar, University of Texas, San Antonio, January 10, 2000.
108. “The Genomics of Pancreatitis”, Human Genetics Seminar Series, University of Pittsburgh, PA, April
7, 2000.
109. “Genetic Testing of Idiopathic and Hereditary Pancreatitis”, AGA Postgraduate Course, Digestive
Disease Week, San Diego, CA, May 20-21, 2000.
110. “Chronic Pancreatitis: Sorting out the Options”, AGA State of the Art Lecture, Digestive Disease
Week, San Diego, CA, May 23, 2000.
111. “Chronic Pancreatitis and Enzyme Therapy”, Rochester, NY, June 7, 2000.
112. “Genetic Alterations in Chronic Pancreatitis”, Chronic Pancreatitis 2000: Novel Concepts in Biology
and Therapy, Bern, Switzerland, August 31 – September 2, 2000.
113. “Pancreatic Cancer”, NOAT 5th Congress Nutritional Oncology: An Integrated Paradigm for the new
Millennium, “Pancreatic Cancer”, Philadelphia, PA, September 9, 2000.
114. “New Insights into Acute and Chronic Pancreatitis”, Medicine Grand Rounds, Rush University,
Chicago, IL, October 11, 2000.
115. “GI Molecular Genetics of Pancreatic Diseases”, The Chicago Society for Gastroenterology, Oak
Park, IL, October 11, 2000.
38
116. “General Revolution in Pancreatic Diseases”, Medical College of Georgia, Augusta, GA, November
7, 2000.
117. “Molecular Insights into Alcoholic Pancreatitis”, 8th United European Gastroenterology Week,
Brussels, November 25-30, 2000.
118. “The Human Genome Project”, Molecular and Human Genetics Course at University of Pittsburgh,
December 11, 2000.
119. “The Genetic Revolution in Pancreatic Diseases”, Department of Anesthesiology/Critical Care
Medicine Grand Rounds, University of Pittsburgh, Pittsburgh, PA, December 13, 2000.
120. “Hereditary Pancreatitis”, The Hospital for Sick Children, Toronto, Canada, January 9-10, 2001.
121. “Pancreatitis: Application of the Genomic Sciences to Human Diseases”, University School of
Pharmacy, January 11, 2001.
122. “Update: Hereditary Pancreatitis”, Grand Rounds, Rhode Island Hospital, Providence, RI, January
18, 2001.
123. “Chronic Pancreatitis – when is heredity important”? St. Luke’s-Roosevelt Hospital, New York, NY,
February 5-6, 2001.
124. "Center for Genomic Sciences - Case Presentations", Medical Grand Rounds, University of
Pittsburgh, Pittsburgh, PA, May 27, 2001.
125. “Molecular Genetics of Pancreatitis”, International Symposium in conjunction with the 32nd Annual
Meeting of the Japan Pancreas Society, Kitakyushu, Japan, and Tohoku University in Sendai, Japan
July 13-14, 2001
126. “Etiology and Pathogenesis of Pancreatitis”, Department of Gastroenterology Annual Post Graduate
CME Course, Lahey Clinic, Brewster, MA July 27-27, 2001.
127. “Advances in Pancreatic Diseases”, Grand Rounds, University of California, San Diego, September
11, 2001.
128. “Acute and Chronic Pancreatitis: State-of-the-Art”, The Third Annual Gastroenterology and
Hepatology Update, Philadelphia, PA, September 20-22, 2001.
129. “Anatomy and Physiology of the Pancreas”, Board Review in Gastroenterology, McLean, VA,
September 29-October 3, 2001.
130. “The role of genetics in pancreatitis and pancreatic cancer”, Epidemiology seminar, Graduate
School of Public Health, Pittsburgh, PA, October 9, 2001.
131. “The Genetic Revolution in Pancreatic Diseases”, Grand Rounds at Children’s Hospital of
Pittsburgh, Pittsburgh, PA, October 11, 2001.
132. “The Mechanism of Pancreatitis”, DDW – Japan 2001, Kyoto, Japan, October 17-20.
133. “Molecular Genetics of Diseases of the Pancreas”, Arthritis Institute Research Conference,
Pittsburgh, PA, January 11, 2002.
134. “The Genetic Revolution in Pancreatic Disease”, Department of Medicine Grand Rounds and
“Chronic Pancreatitis: When is hereditary Important?” GI Research Forum, “Hilda Schwartz Visiting
Professorship", Baylor College of Medicine Gastroenterology Course, Baylor College of Medicine,
February 14-16, 2002.
135. “Chronic Pancreatitis: Diagnosis, Mechanisms and Management”, Frank Brooks Memorial
Symposium, MCP Hahnemann University, Philadelphia, PA, March 7, 2002.
39
136. “Exocrine Pancreas”, Department of Pathology, University of Pittsburgh Medical Center, MSCMP
2730: Molecular mechanisms of tissue growth and differentiation, March 11, 2002.
137. “Genetic Testing is useful in the diagnosis of non hereditary pancreatic conditions”, Controversies in
Gastroenterology, Toronto, April 8-10, 2002
138. “Idiopathic recurrent pancreatitis”, AGA Postgraduate Course, San Francisco, California, May 18-19,
2002.
139. “Hereditary pancreatitis and pancreatic cancer”, 26th International Congress of Internal Medicine,
Kyoto, Japan, May 26-30, 2002.
140. “Chronic Pancreatitis: Genetics and Management”, 2002 AGA-SSG Postgraduate Course
San Sebastian, Spain, June 9, 2002.
141. “Genetic Factors: Facts and Fantasies”, European Pancreatic Club, Heidelberg, Germany, June 19,
2002.
142. “Pancreatitis: What to Do?”, AGA Spring Postgraduate Course, Digestive Diseases Week, Orlando,
FL. May 17-18, 2003.
143. “Acute Pancreatitis: Molecular Biology Update”, Pancreas Club Meeting, Orlando, FL. May 18,
2003.
144. “Genes and Environment in Pancreatic Diseases”, (w/ Dr. Pandol), DDW Meet the Investigator,
Digestive Diseases Week, Orlando, FL. May 18, 2003.
145. “How Genetics Can Help Target Screening”, AGA Clinical Symposium, Digestive Diseases Week,
Orlando, FL. May 20, 2003.
146. “Pancreas and Biliary Disease”, Post-DDW CME Course, Pittsburgh, PA, June 6-7, 2003.
147. “Biology and Management of Pancreatic Cancer”, Lustgarten Foundation for Pancreatic Research
2003 Conference. June 16-17, 2003.
148. “What Can Genetics Tell Us About the Pathophysiology of Chronic Pancreatitis?”, State-of-the-Art
Lecture, European Pancreatic Club XXXV Meeting, Liverpool, UK. June 18-21, 2003.
149. “Genetic Revolution in Pancreatic Diseases”, Mayo Clinic Jacksonville Gut Club, Jacksonville, FL.
September 4, 2003.
150. “Genetic Predispositions in Chronic Pancreatitis”, Brown University, Providence, RI. September 11,
2003.
151. “Anatomy and Physiology of the Pancreas”, William M. Steinberg’s GI Board Review, McLean, VA.
September 24, 2003.
152. “Hereditary Pancreatitis”, North American Society for Pediatric Gastroenterology, Hepatology and
Nutrition, Montréal, Québec, Canada. October 2, 2003.
153. “Pancreatitis: Is it in the Genes?”, American College of Gastoenterology, Boston, Massachusetts.
October 12, 2003.
154. “Genetic Aspects of Pancreatitis”, Mayo Clinic Scottsdale, Scottsdale, Arizona. November 13-15,
2003.
155. “Pancreatitis and the Environment”, Cornell University, New York, New York. November 25, 2003.
156. “Acute Pancreatitis”, Gut Club of Central Louisiana, Alexandria, Louisiana. December 4-5, 2003.
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157. “Genetic Screening in Pancreatic Cancer: Are We There Yet?”, Mayo Clinic Jacksonville,
Jacksonville, Florida. March 5-7, 2004.
158. “An Internist Approach to Pancreatitis”, UPMC Shadyside, Pittsburgh, Pennsylvania. March 15,
2004.
159. “Genetic Determinants in Acute and Chronic Pancreatitis,” David M. Bull Lecture, Wayne State
University, Detroit, Michigan. April 14, 2004.
160. “Hereditary Pancreatitis and Risk for Pancreatic Cancer.“ Symposium on the Genetics and
Development of the Liver and Pancreas, University of California at San Francisco. April 23-25,
2004.
161. “Chronic Pancreatitis: Diagnosis and Therapeutic Procedures,” World Congress of Pediatric
Gastroenterology, Paris, France. July 5-7, 2004.
162. “Diagnosis of chronic pancreatitis and TIGAR-O Classification (version 2.0),” IAP/JPS Joint Meeting,
Sendai International Center, Sendai, Japan. July 11-14, 2004.
163. “Early Diagnosis Using Loss of Heterozygosity,” International Workshop on Biliary Tract Cancer,
Shanghai, China. July 15-17, 2004.
164. “Genetics of CFTR in Pancreatic Physiology and Disease,” University of Texas Health Science
Center, San Antonio, Texas. August 30, 2004
165. Keynote Speaker: “Acute and Chronic Pancreatitis, Pancreatic Cancer.” Advances in the
Multidisciplinary Management of Pancreatic Disease, Ohio State University Medical Center,
Columbus, Ohio. September 10, 2004.
166. Lecturer, Pancreatic Cancer Early Detection Biomarkers Workshop, National Cancer Institute Early
Detection Research Network, Norfolk, Virginia. September 12-13, 2004.
167. “Advances in Recurrent Acute and Chronic Pancreatitis” and “Chronic Pancreatitis as a Complex
Genetic Disease.” Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire. September 2324, 2004.
168. Lecturer, GI Board Review, Baltimore, Maryland. September 29-30, 2004.
169. Speaker, Falk Symposium Gastroenterology Week in Freiburg, Germany. October 12-17, 2004.
170. Speaker, Pancreatic Cancer in Mice and Man: The Penn Workshop 2004, Philadelphia, PA.
December 2-3, 2004.
171. 9th Ibrahim Memorial Oration of the 10th Diabetes and Endocrine Conference of the Diabetic
Association of Bangladesh. December 11, 2004, Dhaka, Bangladesh.
172. Pleniary Address, National Workshop on Tropical Pancreatitis, December 19, 2004, Kochi, India.
173. Lecturer, Mayo Clinic Scottsdale, AZ. March 2-4, 2005.
174. Frank Brooks Memorial Lecturer, “Understanding the Genetics of Pancreatitis.” Thomas Jefferson
University, Philadelphia, PA. April 21-22, 2005.
175. 28th European Cystic Fibrosis Conference, Heraklion, Crete, Greece. June 22-25, 2005.
176. 5th International Symposium for Inherited Diseases of the Pancreas, “Polygenic Traits in Pancreatic
Disorders.” Graz University Campus, Graz, Austria. July 8-12, 2005.
177. Fifth Annual Dartmouth Conference on Liver, Pancreas and Biliary Disease, “Pathophysiology of
Acute and Chronic Pancreatitis,” Lebanon, NH. Sept. 22-24, 2005.
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178. 13th European Gastroenterology Week, “Monogenic and Complex Trait Causes of Pancreatitis.”
Copenhagen, Denmark. October 15-20, 2005.
179. USC Visiting Professor and Grand Rounds, “Present at GI Grand Rounds.” Los Angeles, CA
December 8-9, 2005.
180. Mayo Clinic’s Winter Gastroenterology Meeting, “ New Insights in Chronic Pancreatitis.” Scottsdale,
AZ. March 1, 2006
181. New York Gastroenterology Society, “Advances in Pancreatic Disease.” New York, NY. March 16,
2006.
182. International Symposium on ALPD, Los Angeles, “Genetics in Alcoholic Pancreatitis.” Los Angeles,
CA, May 2006
183. DDW International Meeting/ Meet the Professor and Meet the Investigator. “ Genetic Basic of
Pancreatic Diseases,” Los Angeles, CA, May 2006
184. Visiting Speaker: University of North Carolina at Chapel Hill. “Cancer Screening and Hereditary
Pancreatitis.” Chapel Hill, North Carolina, June 2006.
185. Grand Round Speaker, University of Indiana School of Medicine. “Mechanisms of Pancreatitis.”
Indianapolis, IN, July 2006.
186. Grand Round Speaker, Sixth Annual Dartmouth Conference on Liver, Pancreas and Biliary
Diseases. Medical Grand Rounds: Hans Fromm, MD Memorial Lecture. ” Pathophysiology and
Management of Acute Pancreatitis.” September 15, 2006.
187. Third Annual Symposium on Interventional Endoscopy. “Chronic Pancreatitis: Clinical/Molecular
Paradigms.” University of California, Irvine, September 30, 2006.
188. Third Annual Symposium on Interventional Endoscopy. “Genetic Basis for Chronic Pancreatitis and
its Complications.” University of California, Irvine, September 30, 2006.
189. GI Grand Rounds for Virginia Commonwealth University Medical Center. “Mechanisms of Acute
Pancreatitis.” Richmond, VA, October 12, 2006.
190. ACG 71st Annual Scientific Meeting and Postgraduate Course (CME Activity). “ Idiopathic
Pancreatitis.”. Las Vegas, NV. October 21, 2006.
191. GI and Hepatology Research Seminar Series, Grand Rounds,(CME Activity) ” Why did Mr. Jones
get Chronic Pancreatitis but not Mrs. Smith.” University of Virginia Medical College, Charlottesville,
VA, January 2007.
192. SUCAMPO New Vistas Program, Bethesda, MD, April 6, 2007.
193. Critical Care Medicine Conference, “Pancreatitis: Medical and Surgical Management.” Montefiore
Medical Center, Bronx, NY, April 19, 2007.
194. 21st Annual Comprehensive Update and Board Review. “Prevention of Gastrointestinal Bleeding in
the ICU Critical Care Medicine 2007.” McClean, VA, April 20, 2007.
195. Spanish Digestive Disease Week, Post Graduate Course ( AGA) “ The etiology and complications
of chronic pancreatitis-diminishing role of alcohol.” Madrid, Spain. June 15, 2007.
196. The Scientific Program Meeting, 5th Meeting of the Pancreas Club Cluj, Romania. “Diagnosis in
Pancreatic Diseases.” Cluj, Romania, October 8, 2007.
197. Falk Symposium 161, Future Perspectives in Gastroenterology. “Chronic Pancreatitis.”
International Congress Center, Dresden, Germany, October 12, 2007.
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198. University of Greifswald, invited speaker. “Low prevalence of true alcoholism in Americans with
pancreatitis; results of a 20 center study.” Greifswald, Germany, October 15, 2007.
199. 2nd International Symposium on Alcoholic Liver and Pancreatic Diseases. Poster presentation,
“Pathogenesis of Alcoholic Liver Disease.” Okasa, Japan, October 18, 2007.
200. Australasian Pancreatic Club, Pancreas in Paradise. “Hereditary Pancreatitis.” Sydney, Australia,
October 21, 2007.
201. Seminar, National Gastroenterology. “Course: Bridging Basic and Clinical Sciences Genomics on
Pancreatic Diseases: Challenges and Opportunities,” Leon, Mexico, November 20, 2007.
202. Southern California Research Center for ALPD and Cirrhosis. “Does alcohol predispose to acute or
chronic pancreatitis?” Keck School of Medicine of the University of Southern California, December
7, 2007.
203. Novartis Institutes for BioMedical Research Scientific Seminar Series 2008. “The Pathway from
Pancreatitis to Personalized Medicine” Novartis Pharma AG, Forum 1, Novartis Campus, Basel,
Switzerland, February 8, 2008.
204. 2008 McGowan Institute Scientific Retreat. “Chronic Pancreatitis: Systems approach to a complex,
gene-environment based chronic inflammatory disorder.” Nemacolin Woodlands Resort,
Farmington, PA, March 10-12, 2008.
205. National Pancreas Foundation Fellows Symposium 2008. Joint Group Discussion Moderator, Hilton
Chicago/Indian Lakes Resort, Bloomingdale, IL, April 11-13, 2008.
206. A Day in the GUT XVII: Issues and Controversies in Gastroenterology. “ Causes of Pancreatitis Not
Often Considered” Montefiore Medical Center, Albert Einstein College of Medicine of Yeshiva
University, Bronx, NY. April 18, 2008.
207. Gastroenterology and Hepatology 2008: Challenges and Controversies, AGA Institute Spring
Postgraduate Course, “Pancreatic Cancer: Targeted Chemotherapeutic Options,” San Diego, CA,
May 17-28, 2008.
208. “Pancreatic Cancer: Targeted Chemotherapeutic Options.” Postgraduate Course, Omni San Diego
Hotel, San Diego, CA, Digestive Disease Week, May 18, 2008.
209.
Chronic pancreatitis characterized by constant pain regardless of severity is associated with poorer
quality of life, lower functioning and increased utilization of resource. Poster Presentation, Omni
San Diego Hotel, San Diego, CA, Digestive Disease Week, May 18, 2008.
210. How does patient’s self-reported alcohol use compare with physician’s assessment in Chronic
Pancreatitis (CP)? Poster Presentation, Omni San Diego Hotel, San Diego, CA, Digestive Disease
Week, May 18, 2008.
211. Alcohol and Smoking are independent predictors for Chronic Pancreatitis. Poster Presentation,
Omni San Diego Hotel, San Diego, CA, Digestive Disease Week, May 18, 2008.
212. Current Profile of Chronic Pancreatitis (CP in the USA: Is it a Multifactorial Disease? Poster
Presentation, Omni San Diego Hotel, San Diego, CA, Digestive Disease Week, May 18, 2008.
213. SPINK1 N34S is not associated with the sentinel acute pancreatitis episode but predisposes
patients to recurrent attacks. Poster Presentation, Omni San Diego Hotel, San Diego, CA, Digestive
Disease Week, May 18, 2008.
214. Does the Pain-protective GPT Cyclohydrolase Haplotype Significantly Alter the Severity of Pain in
Humans with Chronic Pancreatitis. Poster Presentation, Omni San Diego Hotel, San Diego, CA,
Digestive Disease Week, May 18, 2008.
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215. Epidermal Growth Factor +61 G/A Polymorphism and Serum Levels in Patients with Acute
Pancreatitis. Poster Presentation, Omni San Diego Hotel, San Diego, CA, Digestive Disease Week,
May 18, 2008.
216. Visfatin polymorphisms and elevated BMI interact to increase the susceptibility to acute pancreatitis.
Poster Presentation, Omni San Diego Hotel, San Diego, CA, Digestive Disease Week, May 18,
2008.
217. The IL-6 – 174 G/G genotype increase susceptibility to acute pancreatitis (AP) in obese subjects.
Poster Presentation, Omni San Diego Hotel, San Diego, CA, Digestive Disease Week, May 18,
2008.
218. A Meta-analysis of Interleukin-6 and Interleukin-8 as Early Markers of Severe Acute Pancreatitis.
Poster Presentation, Omni San Diego Hotel, San Diego, CA, Digestive Disease Week, May 19,
2008.
219. Early Jejunal Feeding Initiation and Optimization of Feeding Goals Improve Clinical Outcomes in
Patients with Severe Acute Pancreatitis. Topic Forum, Omni San Diego Hotel, San Diego, CA,
Digestive Disease Week, May 20, 2008.
220. Dose-dependent Effects of Alcohol and Tobacco on Age of Presentation in Pancreatic Cancer (PC):
A Multicenter, International Study. Poster Presentation, Omni San Diego Hotel, San Diego, CA,
Digestive Disease Week, May 21, 2008.
221. “Pancreatic Cancer: Risk stratification for screening and prevention”. UPCI Annual Retreat,
Greensburgh campus, PA, June 2008.
222. Poster session: Dr. Whitcomb to Chair “Clinical V. Chronic Pancreatitis/Others.” IAP Council
Meeting and also presented “Genetic studies of the pancreas.” Lodz, Poland, June 26, 2008
223. “The genes and environmental factors that cause acute and chronic pancreatitis”. Visiting Professor,
University Medical Center, Hamburg-Eppendorf , Germany, June 30, 2008.
224. William M. Steinberg’s 2008 Board Review in Gastroenterology, “Anatomy and Physiology of the
Pancreas.” Renaissance Harborplace Hotel, Baltimore, MD, September 19-23, 2008.
225. “Early Diagnosis of Pancreatic Cancer.” 7th Annual Symposium on Gastrointestinal Cancers:
Integrating Recent Advances Into Clinical Practice, St. Louis, MO, September 20, 2008.
226. “Personalized Medicine, Use of reverse engineering and mathematical modeling to invent a
revolutionary discipline”. Center for Computational Thinking Seminar Series, Carnegie Mellon
University, October 14, 2008.
227. “What Genetics Taught Us About GI Diseases”, Update in Internal Medicine, Pittsburgh, PA,
October 30, 2008.
228. “Genetic Basis of Digestive Diseases”, Human Genetics 2040, 719 Crabtree Hall, Graduate
School Public Health. November 20, 2008
229. “Pathologphysiology and Management of Acute Pancreatitis”, Critical Care Medicine Grand Rounds,
University of Pittsburgh, Pittsburgh PA, November 19, 2008
230. “Pancreatitis and Personalized Medicine”, Visiting Professor, University of Miami Miller School of
Medicine Grand Rounds, Miami Fla, January 8, 2009
231. The University of Toledo Medical Center, Division of Gastroenterology, Grand Rounds Speaker,
“Acute and Chronic Pancreatitis: Major Breakthroughs in Understanding Complex Diseases.”
Toledo, OH, January 22, 2009.
232. Yale University, 2009 Samuel D. Kushlan Visiting Professor and Speaker, Gastroenterology and
Hepatology Research Grand Rounds, “Chronic pancreatitis: the perfect model for personalized
medicine”, March
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233. Yale University Department of Medicine, 2009 Samuel D. Kushlan Visiting Professor and Speaker at
Medical Grand Rounds, “Acute Pancreatitis: Life-saving Insights.” New Haven, CT, February 26,
2009.
234. Hadassah Greater Pittsburgh Chapter and Hillman Cancer Center joint meeting” The BRCA Genetic
Connection”, lecture “BRCA2 and the risk of Cancer”, Thursday, April 30, 2009.
235. Inflammation and Carcinogenesis of the Pancreas: Genetic Background”, 5th Joint Meeting of the
Japanese Society of Gastroenterology and the American Gastroenterological Association, May 7,
2009
236. Genetic aspects of acute and chronic pancreatitis. Medical Grand Rounds, Tohoku University,
Sendai, Japan, May 10, 2009.
237. Acute Pancreatitis. Mercy Medical Center, Baltimore Medical Center, Baltimore, Maryland, March 4,
2010.
238. Genetics: Lesson 2. British Society of Gastroenterology 22nd Annual Meeting, Liverpool, UK, March
25, 2010.
239. National Commission on Digestive Disease: Research Challenges and Opportunities in Pancreatic
Disease speaker. NPF 5th Annual Fellow Symposium, Bloomingdale, IL April 16-18, 2010.
240. Roundtable Discussion – Developing Cooperative Study Groups speaker. NPF 5th Annual Fellow
Symposium, Bloomingdale, IL April 16-18, 2010
241. Acute Pancreatitis and Chronic Pancreatitis. Poster Presentation, Digestive Disease Week, New
Orleans, LA, May 1-5, 2010.
242. Acute Pancreatitis. European Pancreas Center, Stockholm, Sweden, June 17, 2010.
243. Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society
2010, Invited Speaker, Fukuoka, Japan, July 11-13, 2010.
Conference Director
1997 First International Symposium on Hereditary Pancreatitis, Sheraton Hotel at Station Square,
Pittsburgh PA, April 5-6, 1997
2000 Second International Symposium on Inherited Diseases of the Pancreas, Hyatt Regency Hotel,
Cincinnati, OH. March 19th - 21st, 1999
2001 Third International Symposium on Inherited Diseases of the Pancreas, Milan, Italy, April 5-7, 2001.
2001 Update in GI and Hepatology What’s New and What To Do, Sheraton Hotel Station Square,
Pittsburgh, PA, October 13, 2001.
2002 Cutting Edge in Gastroenterology and Hepatology, University Select Holliday Inn, Pittsburgh PA,
Dec 7, 2002
2003 Fourth International Symposium on Inherited Diseases of the Pancreas. Chicago, Ill Nov 7-9, 2003
2005 Pancreatic Thought Leader Conferences. Pittsburgh, PA. July 25-29, 2005.
2006
2007
2008
Director, National Pancreas Foundation, Fellow’s Symposium, Indian Lake Hilton, Chicago, Il,
April 11-2, 2008.
Co-Director, PancreasFest 2008, July 24-25, 2008 Pittsburgh, PA
Co-Director, GI Division annual CME program, “What’s New and What to Do”, November 13-14,
2008
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Co-Director, Update in Internal Medicine, October 30, 2008
Course Director, What’s New in GI and Hepatology? November 13-14, 2008.
2009
Co-Director, National Pancreas Foundation, Fellow’s Symposium, Indian Lake Hilton, Chicago, Il,
April 17-19, 2009
Course Director, What’s New in GI and Hepatology? November 12, 2009.
2010
Director, PancreasFest, University Club, Pittsburgh, July 29-30, 2010
Co-Director, Sixth International Symposium on Inherited Diseases of the Pancreas. July 29, 2010
Postgraduate Course: Multidisciplinary Strategies for Complex Digestive Diseases, University
Club, Pittsburgh, PA. Thursday & Friday – October 21 & 22, 2010
2011
Course Director, AGA Annual Postgraduate Course, Digestive Disease Week, Chicago Il, May 78, 2011
Director, PancreasFest, University Club, Pittsburgh, July 28-30, 2011
Co-Director, Gastroenterology & Primary Care Collaborations: What’s New in Common GI
Problems, Rivers Club, Pittsburgh PA, September 22-23, 2011
Grants:
Principal Investigator:
Active
NIDDK – 1 T32 DK063922-08, “Digestive Disease Training Program.” $319,983 (7/1/03 – 6/30/13)
NIDDK – 2 R01 DK061451-08. “NAPS 2 Continuation: Genome Wide Association Study of
Pancreatitis.” $455,560 (8/20/08 - 4/30/12)
NIDDK – 5 U01 DK075803-03. “Feeding and Pancreatic Rest in Acute Pancreatitis.” $828,759
(9/1/07 – 12/31/12)
NIDDK – 3 U01 DK075803-03. “Feeding and Pancreatic Rest in Acute Pancreatitis –
Supplement.” $99,232 (9/1/09 – 3/31/12)
NIDDK – 1 R01 DK077906-01A2. “NAPS2-AS: Race-Dependent Risk for Pancreatitis.” $418,199
(5/15/10 – 3/31/14)
Previous
NIH-NIDDK R29 DK45781-01A1 "Regulation of the pancreatic vagus by PP and PYY". Period of
award 5 years, Total cost, $512,066, Direct cost, $349,021 (12/93 through 11/98).
NIH - 1R03DK51954-01 "Genetic Linkage in Patients with Hereditary Pancreatitis”.
2 years. Total cost 150,756, indirect cost $100,000. (9/1/96 through 8/31/98).
Merit Review . "Altered neuroendocrine control of the pancreas in alcoholism". Period of award 4
years. Total cost $362,400 (4/95 through 3/00).
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NIH-AAA 1R01DK50236-01/AA10885-01 "Alcohol and altered regulation of pancreatic secretion".
Period of award 5 years. Total cost $1,150,000 (7/95 through 6/00).
Lustgarten Foundation for Pancreatic Cancer Research, “Development of pancreas gene
enriched microarrays”. Period of award – 1 year (renewable), Total cost - $125,000. (January 1,
2001-December 31, 2001).
NIH - 1 R01 - DK54709-01, “Molecular Genetics of Hereditary Pancreatitis”. 4 years. Total cost
– $911,487 (12/1/98 through 11/30/02).
National Pancreas Foundation “Genetic Linkage Study for Familial Pancreatic Cancer”, 2 year,
$30,000 (9/1/00 through 8/31/02).
Merit Review “Development of Chronic Pancreatitis in Alcoholism” – Period of award 3 years,
Total cost - $338,600 (Spring 2000 – Spring 2003).
Cystic Fibrosis Foundation. CFTR Genotypes Targeting Respiratory or Pancreatic Epithelial
Function. Period of award – 2 years, Total cost - $80,000 (8/1/01 through 7/31/03).
NIDDK – 5 R01 DK61451-02, “North American Pancreatitis Study 2 (NAPS 2),” $405,298. (7/1/02
– 6/30/07).
NIH – 5 R01DK054709-06, “Molecular Genetics of Hereditary Pancreatitis”. 4 years. Total cost –
$911,487 (11/30/02 through 11/30/08).
Solvay Pharmaceutcials. A Study to Investigate the Effect of pancrelipase delayed release
capsules on Maldigestion in Patients with Exocrine Pancreatic Insufficiency Due to Chronic
Pancreatitis and Pancreatectomy. (8/07 - 10/09) $128,552 Total costs ($102,842 Direct Costs)
Co-investigator :
SLaptamer-Based Array Technology for Discovery of Pancreatic Cancer Plasma Biomarkers
Specimen Collection for the National Tissue and Serum Bank: Patients at Risk for Colo-rectal
Carcinoma. NCI
PCI #93-03. Prostate, Lung, Colon and Ovarian Cancer Screening Trial. Period of award, 10
years (as part of a National Cancer Institute multicenter trial).
Mechanism of PDT-Induced Esophageal Stricture. James D. Luketich, M.D., Principal
Investigator.
Epidemiological and Molecular Genetic Characterization of persons and families with
gastroesophageal reflux disease – blood drawing. Susan R. Orenstein, M.D., Principal
Investigator.
Committees:
1)
Nutrition Support Committee - Chairman
Oakland VA Medical Center
2)
Research and Development Committee
Oakland VA Medical Center
3)
MD/PhD Supervisory Committee
University of Pittsburgh
4)
UPP Policy Committee (1999 – 2001)
47
5)
Curriculum Committee for Genetics (2000)
6)
Curriculum Committee Task Force
7)
General Clinical Research Committee
8)
Study Section Boundary Team
Center for Scientific Review at the NIH
9)
Committee X: Research
LCME Accreditation Self-Study
10)
Chair of NIH/NIAAA study section (2003)
11)
Advisor for Solvay Pharmaceuticals, Pancreatic Advisory Board (2003)
12)
Advisor for Solvay Pharmaceuticals, Pancreatic Advisory Board (2004)
13)
Advisor for Novartis International Advisory Board Meeting (2005)
14)
NIH Review Group for NIAAA–ZAA1 JJ (14) Fellowships (2007)
15)
AGA Institute, Research Award Panel (January 1, 2010 – present)
Other academic activities:
Associate Editor - Digestive Diseases and Sciences
Associate Editor – Pancreas
Editorial Board – Pancreas
Selected Summaries contributor - GASTROENTEROLOGY
National Cancer Institute Planning Review Group for Pancreatic Cancer (2001)
Section Editor - Current Treatment Options in Gastroenterology
Associate Editor - Pancreatology
Editorial Board - Pancreatology
Associate Member - Center for Pharmacogenetics (2001)
Editorial Board – Clinical Gastroenterology and Hepatology (2002)
Editorial Board – American Journal Physiology: Gastrointestinal & Liver Physiology
Editorial Board - Journal of the Pancreas
Peer Reviewer (partial listing)
Alimentary Pharmacology and Therapeutics
American Journal of Gastroenterology
American Journal of Pathology
American Journal of Physiology - Gastroenterology
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Digestive Diseases and Sciences
FASEB Journal
Gastroenterology
Gut
Journal of the American Medical Association (JAMA)
Lancet
Nature
Nature Clinical Practice
New England Journal of Medicine
Pancreas
Pancreatology
48
European Journal of Pediatrics
International Journal of Pancreatology
International Journal of Cancer
Grant Review Committees - National
National Institutes of Health - NIDDK, Spring 1995
Department of Veterans Affairs - Merit Review Board for Gastroenterology, Fall 1995, Spring 1996.
National Institutes of Health - GMA 2, October 1998
Department of Defense Congressional Interest Research on Health-Related Topics – American
Institute of Biological Sciences, FY 99
External Advisory Board for SPORE Grant for University of Nebraska Medical Center/Eppley
Clinical Cancer Center
National Heart, Lung, and Blood Institute Special Emphasis Panel for RFA HL-04-008, June 2004.
Cancer Genetics, February 2006.
Grant Review for NIH, “Support of NIDDK Program Project Grants” (2011/05 ZDK1 GRB-9 (M2),
March 11, 2011 – Chairperson.
AGA Research Scholar Award and Vertex Research Scholar Award Review Panel, American
Gastroenterological Association, March 2011
AGA-Horizon Pharma Fellow Abstract Prize Review. April 2011
Services:
University and Medical School
Director, Center for Genomic Sciences
MD/PhD Advisor Committee
Associate Chief, Division of Gastroenterology and Hepatology
Search Committee, Chairman, Human Genetics
Medicine Grand Rounds Committee
Curriculum Committee for Genetics
Board of Scientific Counselors for the Pittsburgh Development Center
Search Committee, Division Chief for Genetics in the Department of Pediatrics
Molecular Medicine Institute
Curriculum Vision Task Force
Search Committee, Rheumatology
Institutional Review Board (2002-2005)
Community Activities
Chief, Gastroenterology and Hepatology Section, VA Medical Center (through 7/98)
Attending Physician, UPMC Presbyterian
Staff Physician, VA Pittsburgh Health Care System
Staff Physician, Shadyside Hospital
Staff Physician, Passavant Hospital
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