Pinky S. Tiwari, M.D., P.A. Diplomate, American Board of Neurology Diplomate, American Board of Electrodiagnostic Medicine St. Luke’s Medical Tower 6624 Fannin, Suite 2190 Houston, TX 77030 Telephone: (713) 790 – 1775 www.texasneuro.com Fax: (713) 790 – 1605 ZOMIG ZOLMITRIPTAN - ORAL Pronunciation: (zol-meh-TRIP-tan) BRAND NAME(S): Zomig USAGE: This medication is a "triptan"-type drug used to treat migraine headache attacks. It does not prevent migraine headaches from occurring and should not be used for other types of headaches (e.g., cluster headaches). HOW TO USE Take this drug by mouth as directed. If relief occurs after one dose, but the headache returns, the dose may be repeated after 2 hours if so directed by your doctor. If you have no relief with the first dose, do not take a second dose without consulting your doctor. Do not take more than 10mg in a 24 hour period. Read the Patient Information Leaflet available from your pharmacist. If you have any questions, consult your doctor or pharmacist. If you have never taken this medication before and you have risk factors for heart disease (see Precautions), you may be advised to take the very first dose in your doctor's office in order to monitor for rare but serious heart problems (e.g., heart attack). SIDE EFFECTS: Nausea, dry mouth, sweating, weakness, dizziness, or drowsiness may occur. If these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: tingling or numbness of hands or feet, pain/pressure/tightness in any body part (e.g., chest, throat, jaw, neck). Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fast/slow/irregular heartbeat, severe stomach/abdominal pain, bloody diarrhea, vision changes, one-sided weakness, slurred speech, confusion. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. PRECAUTIONS: Before taking zolmitriptan, tell your doctor or pharmacist if you are allergic to it; or to other "triptan" migraine drugs; or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: chest pain (angina), history of heart attack, other heart or blood vessel disease (e.g., coronary artery disease with vasospasm or ischemia), uncontrolled high blood pressure, history of stroke, other types of headaches (hemiplegic or basilar migraines), certain blood circulation problems (e.g., peripheral vascular disease, ischemic bowel disease), severe liver disease. Before using this medication, tell your doctor or pharmacist if you have risk factors for heart disease including: high cholesterol, high blood pressure, diabetes, smoking history, family history of heart disease or stroke, obesity. Caution is also recommended in women after menopause or after removal of the ovaries, and men over 40 years old because of an increased risk for undiagnosed heart disease. Before using this medication, tell your doctor or pharmacist your medical history, especially of: other blood circulation disorders (e.g., Raynaud's syndrome). This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug is excreted into breast milk. Consult your doctor before breast-feeding. DRUG INTERACTIONS: Certain medications taken with this product could result in serious drug interactions. Do not take MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) for at least 2 weeks before or after taking this drug. Do not take other "triptan" migraine drugs (e.g., sumatriptan), or ergot-type drugs (e.g., dihydroergotamine, ergotamine, methysergide) within 24 hours of taking zolmitriptan. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: birth control pills, cimetidine, sibutramine, "serotonin type" medications (e.g., SSRI antidepressants such as fluoxetine, sertraline). Tell your doctor if you take drugs that cause drowsiness such as: medicine for sleep (e.g., sedatives), tranquilizers, antianxiety drugs (e.g., diazepam), narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), anti-seizure drugs (e.g., carbamazepine), muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products. Do not start or stop any medicine without doctor or pharmacist approval. OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include drowsiness. NOTES: Do not share this medication with others. Medical tests may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. MISSED DOSE: Not applicable.