Curriculum Vitae
Jan Rijn Zeevaart
798 Fauna Road.
NECSA (Building 1600)
Florauna
PO Box 582
0182
Pretoria
South Africa
0001
+27 (0)84 754 7834
+ 27 (0)12 305 5786
Educational qualifications
School
:
Matriculated from Hoërskool Noord-Oosrand
University
:
University of Pretoria
Year
:
1991-1994
Degrees obtained
:
BSc (with distinction), 1993
:
BSc(Honours) in Chemistry with distinction, 1994
(Part time while employed at NECSA)
University
University
:
University of Cape Town
:
MSc in Chemistry, 1997
:
Delft University of Technology (The Netherlands)
:
PhD, 2001
EANM Postgraduate Diploma for Radiopharmaceutical Chemistry / Radiopharmacy:

Module III: CEA/INSTN, Saclay, France, 2009
Prizes received
Departmental Chemistry prize
:
Various prizes as best undergraduate Chemistry
student
The SACI James Moir Medal
:
Best performance in Chemistry at honours level if
graduated with distinction. 1994
Young Investigator Travel Award to :
attend the12th International Congress
of Radiation Research
Award to travel to the conference for investigators
within in 5 years of reward of last degree
August 17 – 22, 2003 Brisbane, Australia
The SACI Raikes Medal 2007
:
Chemical researcher in South Africa under the age of
35
whose
original
chemical
research
shows
outstanding promise
NRF Rating
:
C3 (2008-2014)
:
1995 –
:
Head of Radiochemistry
:
Development of new radiopharmaceutials used in the
Employment
NECSA
South African Nuclear Energy
Corporation (previously AEC of SA)
Current position
Scope of work:
Institutional
treatment of secondary bone metastasis
Commercial
:
Development of isotope production methods to exploit the
use of the SAFARI-I research reactor for commercial ends
North West University (CARST)
:
Extraordinary Associate Professor (2006-2010)
North West University
:
Extraordinary Associate Professor (2011-2013)
(Drug Research and Development)
Publications (33), books (1) and chapters in books (3)
Total impact factor: 59,694
Total number of citation: 193
J.R. Zeevaart, N.V. Jarvis, I. Cukrowski and G.E. Jackson. Blood plasma modelling of the in vivo
behaviour of bisphosphonate-metal-ion complexes as radiopharmaceuticals. S. Afr. J. Chem., 1997, 50,
189-194.
Citations: 18
Impact factor: 0.567
I. Cukrowski, J.R. Zeevaart and N.V. Jarvis. A potentiometric and differential pulse polarographic
study of CdII with 1-hydroxyethylenediphosphonic acid. Anal. Chim. Acta, 1999, 379, 217-226.
Citations: 21
Impact factor: 4.114
J.R. Zeevaart, N.V. Jarvis, W.K.A. Louw, G.E. Jackson and R Mouton. Metal-ion speciation in blood
plasma incorporating the biphosphonate, 1-hydroxy-4-aminopropilydenediphosphonate (APD), in
therapeutic radiopharmaceuticals. J. Inorg. Biochem., 1999, 73, 265-272.
Cited by KH Thompson & C Orvig in Boon and Bane of Metal ions in Medicine, Science 2003, 300 ,
936-939 (IR Zeevaart and not JR Zeevaart)
Citations: 26
Impact factor: 3.495
J.R. Zeevaart, W.K.A. Louw, N.V. Jarvis, J.M. Wagener, I.C. Dormehl and R.J. Milner. Comparison
between blood plasma models (ECCLES) for 153Sm and 166Ho complexed to diphosphonate ligands
(possible radiotherapeutic bone agents) and their in vivo behaviour as studied in non-human primates.
Isotope Production and Applications in the 21st Century, N.R. Stevenson, World Scientific, 2000, 403406, ISBN:981-02-4200-x.
Citations: 0
J.R. Zeevaart, N.V. Jarvis, W.K.A. Louw and G.E. Jackson. Metal-ion speciation in blood plasma
incorporating the tetraphosphonate, N, N,-dimethylenephosphonate-1-hydroxy-4-aminopropilydenediphosphonate (APDDMP), in therapeutic radiopharmaceuticals. J. Inorg. Biochem., 2001, 83, 5765.
Citations: 27
Impact factor: 3.495
J.R. Zeevaart, W.K.A. Louw, N.V. Jarvis and J.M. Wagener. Comparison of the predicted behaviour of
153
Sm, 166Ho and 117mSn containing bone agents, employing blood plasma models (ECCLES), with in
vivo results as studied in animals. J. Lab. Comp. Radiopharm., 2001, 44, suppl 1, S799-S801.
Citations: 1
Impact factor: 0.913
J.R. Zeevaart, Metal-ion speciation in blood plasma as a tool in predicting the in vivo behaviour of
potential bone-seeking radiopharmaceuticals. PhD Thesis, Delft University Press, 2001, ISBN 90-4072242-0. Nr of pages 163
Citations: 4
N.V. Jarvis, J.R. Zeevaart, J.M. Wagener, W.K.A. Louw, I.C. Dormehl, R.J. Milner and E. Killian.
Metal-ion speciation in blood plasma incorporating the water-soluble polymer, polyethyleneimine
functionalised with methylene-phosphonate groups, in therapeutic radiopharmaceuticals. Radiochimica
Acta, 2002, 12, 237-246.
Citations: 5
Impact factor: 1.459
J.R. Zeevaart, W.K.A. Louw, N.V. Jarvis, J.M. Wagener, Z.I. Kolar and R.A.M.J. Claessens.
Speciation studies of SnII in blood plasma incorporating proposed bone-seeking ligands as potential
therapeutic radiopharmaceuticals. Journal of Radioanalytical and Nuclear Chemistry, 2003, 257, 8391.
Citations: 11
Impact factor: 1.52
J.R. Zeevaart, W.K.A. Louw, Z.I. Kolar, E. Kilian, F.E. Jansen van Rensburg, I.C. Dormehl.
Biodistribution and pharmacokinetics of variously molecular sized 117mSn(II)-polyethyleneiminomethyl
phosphonate (PEI-MP) complexes in the normal primate model as a potential selective therapeutic bone
agent. Arzneimittel-Forschung/Drug Research, 2004, 54, 340-347.
Citations: 12
Impact factor: 0.632
T.E. Nomkoko, G.E. Jackson, B.S. Nakani, W. K. A. Louw, J.R. Zeevaart. Thermodynamic and
biodistribution studies of Zn(II), Ca(II),Gd(III) and Cu(II) complexes of 3,3,9,9-tetramethyl-4,8diazaundecane-2,10-dione dioxime. J. Chem. Soc. Dalton, 2004, 741-749.
Citations: 3
Impact factor: 3.838
J.R. Zeevaart, D.R. Jansen, M.F. Botelho, A. Abrunhosa, C. Gomes, L. Metello, Z.I. Kolar, G.C.
Krijger, W.K.A. Louw, I.C. Dormehl. Comparison of the predicted in vivo behaviour of the Sn(II)APDDMP complex and the results as studied in a rodent model. J. Inorg. Biochem. 2004, 98, 15231530.
Citations: 6
Impact factor: 3.495
I. Cukrowski, D.M. Mogano, J.R. Zeevaart. Voltametry as a virtual potentiometric sensor in modelling
of a metal-ligand system and refinement of stability constants. Part 4. An electrochemical study of NiII
complexes with methylene disphosphonic acid. J. Inorg. Biochem. 2005, 99, 2308-2321.
Citations: 6
Impact factor: 3.495
J.R. Zeevaart, S.A. Shady, A. Goede, M.M. Phetoe, Determination of adsorption characteristics for
different Cs selective resins, Proceedings of the 5th International Conference on Isotopes, Editors; H.
Bonet, B.J. Allen, C. Chemaly, Medimond, ISBN 88-7587-186-8, 227-230.
Citations: 0
J.R. Zeevaart, S. Olsen. Recent trends in the concept of specific activity: Impact on radiochemical and
radiopharmaceutical producers. Applied Radiation and Isotopes, 2006, 64, 812-814.
Citations: 6
Impact factor: 1.202
M.F. Botelho, F. Caramelo, C. Gomes, J.R. Zeevaart , W.K.A. Louw , I.C. Dormehl, Z.I. Kolar , G.C.
Krijger , R.J. Milner. 117mSn-APDDMP for Osteosarcoma Treatment. Biodistribution and Dosimetric
Considerations. Radioprotecção (Radioprotection - The official journal of the Portuguese Health
Physics Society), 2006, vol 2, nr. 8&9 ISSN-0874-7016
Citations: 0
J. van Rooyen, Z. Szucs, J.R. Zeevaart. A possible in vivo generator 103Pd/103mRh - Recoil
considerations. Applied Radiation and Isotopes, October 2008, 66(10), 1346-1349.
Citations: 6
Impact factor: 1.202
D. R. Jansen, J. R. Zeevaart, Z. I. Kolar, K. Djanashvili, J.A. Peters, G. C. Krijger. P-31 NMR study of
the valence stability of Tin in its 1-hydroxyethylene-diphosponate (HEDP) and N,N’,N’trimethylenephosphonate-polyethyleneimine (PEI-MP) complexes. Polyhedron, 2008, 27, 1779–1786.
Citations: 6
Impact factor: 2.118
J.M. Wagener, M. K. Dithebe, M.D. Mogano, I. Cukrowski, J.R. Zeevaart. Modelling of the blood
plasma species of biguanide derivates exhibiting potential as diagnostic radiopharmaceuticals. South
African Journal of Chemistry, 2008, 61, 82-92.
Citations: 1
Impact factor: 0.567
Z. Szucs , D. Steyn, E. Vermeulen, I.J. Van der Walt, K. Moodley, S. Verryn. J.R. Zeevaart. Separation
of 103Pd from metal Rh by thermal diffusion impossible. 7th International Conference on Nuclear and
Radiochemistry. NRC 7. Budapest, Hungary, 24-29 Aug., 2008. Proceedings. CD-ROM 0 (2008)1-1./
0.000
Citations: 2
D. Jansen, J.R. Zeevaart, A. Denkova, Z. Kolar, G Krijger. The Hydroxyapatite Chemisorption of
N,N',N'-trimethylenephosphonate-polyethyleneimine (PEI-MP) Combined with Sn2+ or Sn4+.
Langmuir 2009, 25, 2790 – 2796.
Citations: 3
Impact factor: 4.186
M.J. Nell, J.M. Wagener, J.R. Zeevaart, E. Kilian, M.A. Mamo, M. Layh, M. Coyanis, C.E.J. van
Rensburg. The anti-tumour properties and biodistribution (as determined by the radiolablled equivalent)
of Au-compounds intended as potential chemotherapeutics Applied Radiation and Isotopes. 2009, 67,
1370–1376.
Citations: 3
Impact factor: 1.202
Z. Szucs, J. Van Rooyen, J.R. Zeevaart. Recoil effects on ß-decaying in vivo generators, interpreted for
103
Pd/103Rh. Applied Radiation and Isotopes. 2009, 67, 1401-1404.
Citations: 6
Impact factor: 1.202
J.R. Zeevaart, J.M. Wagener, M. Neves, M.C. Costa, C. Rodrigues, M. Dithebe, E. Kilian, I.
Cukrowski. 99mTc-labelled biguanide derivatives: chemical speciation modelling thereof and evaluation
in vervets; J Radioanal Nucl Chem. 283, 2010, 123-131.
Citations: 2
Impact factor: 1.52
D.R. Jansen, G.C. Krijger, J. Wagener, R.M. Senwedi, K. Gabanamotse, M. Kgadiete, Z.I. Kolar, J.R.
Zeevaart.
Blood plasma model predictions for the proposed bone-seeking radiopharmaceutical
[117Sn]Sn(IV)-N,N,N’-trimethylenephosphonate-poly(ethyleneimine);
Biochemistry, 2009, 103,1265-1272.
Citations: 1
Impact factor: 3.495
Journal
of
Inorganic
Janine Suthiram, Kanyisa Mhlaba, Jan Rijn Zeevaart, Hendrik G Visser and Andreas Roodt,
Tetrathylammonium tricarbonly-chlorido(pyrazine-2-carboxylato-N1, O) – rhenate (I) Acta Cryst E,
2009, E 65, m1395
Citations: 1
Impact factor: 0.35
Zoltan Szucs, Danie Moolman, Sabine Verryn, Jan Rijn Zeevaart, The metal Rhodium does not have
allotropes, Journal of Radioanalytical and Nuclear Chemistry, 284 (1), 2010, 239-243.
Citations: 1
Impact factor: 1.52
Zoltan Szucs, Mike Sathekge, Biljana Marjanovic-Painter, Judith Wagener, Thato Sello, Carl Wagener,
Jan Rijn Zeevaart. Synthesis of I-131 Labelled 4-Iodo-Phenyl-Acetic acid Journal of Labelled
Compounds and Radiopharmaceuticals, 2010, 54, 54-58. Published online – 12 Jan 2010
Citations: 1
Impact factor: 0.913
Janine Suthiram, Jan Rijn Zeevaart, Hendrik G Visser and Andreas Roodt, Tetrathylammonium
tricarbonly-chlorido(quinoxaline-2-carboxylato-N1, O) – rhenate (I) Acta Cryst E, 2010, E 66. m1042m1043.
Citations: 0
Impact factor: 0.35
MF Botelho, AM Abrantes, JR Zeevaart , DR Jansen, A Turtoi , ZI Kolar, M Neves, FHA
Schneeweiss, GC Krijger, IC Dormehl. Comparison of the Therapeutic Potential of the
Polyphosphonate Pei-Mp Labeled with 99mtc, 117msn, 186re and 188re. Acta Médica Portuguesa, II
Série, 2010, 23, 313.
Citations: 0
Impact factor: 0.256
David R Jansen, Gerard C. Krijger, Zvonimir. I. Kolar, Bernard A. Zonneberg, Jan Rijn Zeevaart Bone
targeting in the radiotherapeutic treatment of bone malignancies. Current Drug Discovery Technologies
2010; 7(4): 233-246.
Citations: 11
Impact factor: 4.90
Jan Rijn Zeevaart, Zoltan Szucs, Sandor Takacs, Neil V. Jarvis, David. R. Jansen. Recoil and
conversion electron considerations of the 166Dyl166Ho in vivo generator. Radiochimica Acta. 2012,
100, 109-113.
Citations: 1
Impact factor: 1.459
O.D. Maslov, G. Ya. Starodub, G.K. Vostokin, M.V. Gustova, S.N. Dmitriev, V.N. Shvetsov, S.
Takacs, Z. Szucs, D. Jansen, J.R. Zeevaart. The production of 117mSn with high specific activity by
cyclotron. Applied Radiation and Isotopes, 2011, 69 (7), 917-1102.
Citations: 2
Impact factor: 1.202
Sepini, L., Jarvis, N.V., Jansen, D.R., Zeevaart, J.R. Thermodynamic evaluation of the stability of the
bone-seeking radiopharmaceutical [117Lu]Lu(III)-DOTP under simulated blood plasma conditions.
Analitica Chimica Acta. 730 (2012) 66– 70 http://dx.doi.org/10.1016/j.aca.2011.10.068
Citations: 0
Impact factor: 4.114
Jan Rijn Zeevaart, Zoltan Szucs, Sandor Takacs, Johann van Rooyen, David Jansen. Recoil and
conversion electron implications to be taken into account in the design of therapeutic
radiopharmaceuticals utilising in vivo generators. Journal of Labelled Compounds and
Radiopharmaceuticals, 2012, 55, 115-119
Citations: 0
Impact factor: 0.913
Jan Rijn Zeevaart, Zoltan Szucs, Tamsyn Pulker, Thato Sello, Jacqueline Bracher, Mike Sathekge.
Biodistribution and pharmacokinetics of I-131 labelled 4-Iodophenulacetic acid. Accepted for
publication by Current Radiopharmaceuticals. doi: 10.2174/1874212222801184710
Venter, L., Jansen, D., Wagener, J., Fourie, P.B., Zeevaart, J.R. Characterization of radiolabelled dry
powder leucine, a constituent of inhalable capreomycin. Accepted for publication by; Drug delivery
letters.
Conference Papers (70), including invited lecture (4) and invited plenary lecture (2)
J.R. Zeevaart and N.V. Jarvis, Complexation of trivalent lanthanides by three diphosphonate ligands in
blood plasma
33rd Convention of the South African Chemical Institute, Cape Town, South Africa 1995.
J.R. Zeevaart, N.V. Jarvis, G.E. Jackson and I. Cukrowski. Investigation into the use of 166Ho
complexed to diphosphonate ligands as possible radiopharmaceuticals for bone cancer patients.
4th International Symposium on Applied Bio-inorganic Chemistry (4th ISABC), Cape Town, South
Africa, 1997.
N.V. Jarvis, J.R. Zeevaart, , J.M. Wagener, G.E. Jackson and I. Cukrowski. Blood plasma models
(ECCLES) for 153Sm and 166Ho complexed to diphosphonate ligands.
34th Convention of the South African Chemical Institute, Durban, South Africa 1998.
J.R. Zeevaart, W.K.A. Louw, N.V. Jarvis, J.M. Wagener, I.C. Dormehl and R.J. Milner. Comparison
between blood plasma models (ECCLES) for 153Sm and 166Ho complexed to diphosphonate ligands
(possible radiotherapeutic bone agents) and their in vivo behaviour as studied in non-human primates.
3rd International Conference on Isotopes (3ICI), Vancouver, Canada 1999.
J.R. Zeevaart, N.V. Jarvis, W.K.A. Louw, J.M. Wagener, I.C. Dormehl and R.J. Milner. Comparison
between blood plasma models (ECCLES) for 153Sm and 166Ho complexed to diphosphonate ligands
(possible radiotherapeutic bone agents) and their in vivo behaviour as studied in non-human primates.
35th Convention of the South African Chemical Institute (SACI-2000), Potchefstroom, South Africa
2000.
J.R. Zeevaart, W.K.A. Louw, N.V. Jarvis and J.M. Wagener. Comparison of the predicted behaviour of
153
Sm, 166Ho and 117mSn containing bone agents, employing blood plasma models (ECCLES), with in
vivo results as studied in animals.
12th International Symposium on Radiopharmaceutical Chemistry (12thISRC), Interlaken, Switzerland,
2001.
Published in J. Lab. Comp. Radiopharm. 44, suppl. 1, S799-S801, 2001.
J.R. Zeevaart, N.V. Jarvis, W.K.A. Louw, J.M. Wagener, Z.I. Kolar, R.A.M.J. Claessens. A
thermodynamic approach towards the evaluation and design of bone-seeking radiopharmaceuticals as
illustrated for 117mSn(II)-PEI-MP.
4th International Conference on Isotopes (4ICI), Cape Town, South Africa 2002.
J.R. Zeevaart, N.V. Jarvis, W.K.A. Louw, J.M. Wagener, Z.I. Kolar, R.A.M.J. Claessens A
thermodynamic approach towards the evaluation and design of bone-seeking radiopharmaceuticals as
illustrated for 117mSn(II)-PEI-MP.
SACI 2002, Port Elizabeth, South Africa, 2002.
W.K.A. Louw, J.R. Zeevaart, Z.I. Kolar, I.C Dormehl, J.M. Wagener, R. Milner, E. Kilian, F.H.A.
Schneeweiss 117mSn and 186Re radiolabelling of polyethyleneiminomethyl phosphonic acid (PEI-MP),
apotential selective therapeutic bone tumour seeker.
South African Society of Nuclear Medicine, Stellenbosch, South Africa, 4-7 Dec. 2002.
Published in Nucl. Med. Comm. , 23, p.1223-1224, 2002.
J.R. Zeevaart, W.K.A. Louw, D.R. Jansen, J.M. Wagener, M.F. Botelho, C. Gomes, L. Metello, A.
Abrunhosa, Z.I.Kolar, I.C. Dormehl. Comparison of the predicted behaviour of 117mSn-APDDMP and
the in vivo results as studied in rats.
SACI Inorganic ’03 conference, Roodevallei, Pretoria, Sout Africa, June 2003.
D.R. Jansen, J.R. Zeevaart, W.K.A. Louw, J.M. Wagener Formation constants for the complexation of
APDDMP with Sn(II).
SACI Inorganic ’03 conference, Roodevallei, Pretoria, Sout Africa, June 2003.
F. Botelho, I. Dormehl, W. Louw, J.R. Zeevaart, C. Gomes, Z. Kolar, A. Abrunhosa, L. Metello, R.
Milner, J. de Lima, F. Schneeweiss, Polyethyleneiminomethyl phosphonate (PEI-MP) for selectively
targeting bone malignancies,
European Association of Nuclear Medicine, Amsterdam, the Netherlands, 13 – 27 Aug. 2003.
Published in Eur. J. Nucl. Med. Mol Imaging 30, suppl. 2, S338, 2003.
J.R. Zeevaart, W. Louw, J.M. Wagener, F. Botelho, C. Gomes, A. Abrunhosa, L. Metello, Z. Kolar, I.
Dormehl, Selective tumour localisation of the bone-seeking radiopharmaceutical 117mSn(II)-PEI-MP as
studied in osteosarcoma containing mice,
15th International Symposium on Radiopharmaceutical Chemistry, Sydney, Australia, 10-14 Aug. 2003.
Published in J. Lab. Comp. Radiopharm. 46, suppl. 1, S100, 2003
J.R. Zeevaart, W. Louw, J.M. Wagener, I. Dormehl, E. Killian. Selective carriers for the conversion
electron radionuclides, 117mSn and 195mPt as potential therapeutic bone agents,
12th International Congress on Radiation Research, Brisbane, Australia, 17-21 Aug. 2003.
Z.I. Kolar, R.A.M.J. Claessen, J.R. Zeevaart and G.C. Krijger, Interfacial chemistry in aqueous tinbisphosphonate / hydroxyapatite systems,
17th Conference of the European Colloid & Interface Science Society, Firenze, Italy, 21 -26 Sept. 2003.
F.H.A. Schneeweiss, I.C Dormehl, W.K.A. Louw, J.R. Zeevaart, Z.I. Kolar, F. Botelho, J Wagener, R.
Milner, A Abrunhosa, C. Gomes, L. Metello, L de Lima, Radioiaktive Markierung von
Polyethyleniminomethyl-phosphonsäure (PEI-MP) mit 117mSn und dessen Reaktion mit auf
Nacktmäusen transplantierten Osteosarcoma,
7. Jahrestagung der Gesellschaft fur Biologische Strahlenforschung, 31 March – 2 April 2004,
Darmstadt, Germany.
Published in Proceedings the of the above, ISBN 3-00-013476-X
L. Metello , J.R Zeevaart, W.K.A. Louw, D.R. Jansen, J.M. Wagener, M.F. Botelho, C. Gomes, A.
Abrunhosa, Z.I. Kolar, I.C. Dormehl. In vivo and in vitro biodistribution studies of 117mSn-APDDMP
in Wistar rats
12th European Symposium on Radiopharmacy and Radiopharmaceuticals, Sept 9 - 12, 2004 Gdansk,
Poland.
Zeevaart JR, Louw WKA, Jansen DR, Botelho MF, Gomes C, Metello L, Abrunhosa A, Kolar ZI,
Krijger GC, Dormehl IC. Comparison of tumour uptake in different types of osteosarcoma mice as
studied with the potential bone-seeking radiopharmaceutical, 117mSn(II)-PEI-MP
INTERNATIONAL CONGRESS OF RADIOPHARMACY & RADIOPHARMACEUTICAL
CHEMISTRY, Sept 25-29, 2004 Istanbul, Turkey, Published in World J. Nucl. Med. 3, 237 (2004)
J.R. Zeevaart, S.A. Shady, A. Goede, M.M. Phetoe, Determination of adsorption characteristics for
different Cs selective resins
J.M. Wagener, O. Perera, J.R. Zeevaart; Production of I125-progesterone tracer. (5th International
conference on Isotopes. April 25-29, 2005, Brussels,Belguim)
J.M. Wagener, J.R. Zeevaart, M. Neves, M.C. Costa, C. Rodrigues, M.K. Dithebe, O. Knoesen and
99m
W.K. Louw.
TC LABELED BIGUANIDE DERIVATIVES: CHEMICAL SPECIATION
MODELLING OF AND EVALUATION IN VERVETS.
16th Int. Sym. on Radiopharmaceutical Chem. in Iowa City, USA, June 24-28, 2005.
Published in J. Lab. Comp. Radiopharm. 48, suppl. 1, S260, 2005.
M. F. Botelho, F. Caramelo, C. Gomes, J. R. Zeevaart , W.K.A. Louw , I.C. Dormehl, Z.I. Kolar , G.C.
Krijger , R.J. Milner. Biodistribution and Dosimetric Calculations for 117mSn-APDDMP, a Potential
Osteosarcoma Treatment Agent.
Primeiras Jornadas Luso Brasileiras de Protecção Contra Radiações e Décimas Primeiras Jornadas
Portuguesas de Protecção Contra Radiações (1st Luso-Brasilian Meeting of Protection against
Radiation and XI Portuguese Meeting of Protection against Radiation), Lisbon 25 November, 2005.
I. Dormehl, W. Louw , J.R. Zeevaart, Z. Kolar, F. Botelho, J. Wagener, R. Milner, A. Abrunhosa, C.
Gomes, L. Metello, F. Schneeweiss, J. de Lima. 117mSn and 186Re radiolabelling of
Polyethyleneiminomethyl phosphonate (PEI-MP), followed by in vivo targeting of induced
osteosarcoma in nude mice.
Radioactive isotopes in clinical medicine and research - 27th Int symposium, Bad Gastein, Austria, 1114 January 2006.
L. Metello, M.F. Botelho, J.R. Zeevaart , I.C. Dormehl, W.K.A. Louw , F. Caramelo, C. Gomes, M.
Neves, Z.I. Kolar , G.C. Krijger, R.J. Milner, Comparison of the polyphosphonate; PEI-MP labeled
with 117mSn and 186Re as potential therapeutic bone agents,
European Symposium on Radiopharmacy and Radiopharmaceuticals, Lucca, Italy, 30 March- 2 April
2006.
Published in Q. J. Nucl. Med. 50 suppl. 1 p 49, 2006
F. Botelho, J.R. Zeevaart, .I Dormehl, W. Louw, F. Caramelo, L. Metello, C. Gomes, M. Neves, C.
Sena, A.N. Abrantes, Z. Kolar, G. Krijger, Dosimetric evaluations of the polyphosphonate; PEI-MP
labeled with Sn-117m, Re-186 and Tc-99m as potential diagnosis/therapeutic bone agents. European
Association of Nuclear Medicine, Athens, Greece, the Netherlands, 1-3 October 2006.
Published in Eur. J. Nucl. Med. Mol Imaging 33, suppl. 2, S309, 2006.
J.R. Zeevaart, J.M. Wagener, M.J. Nell, E. Kilian, M.A. Mamo, M. Layh, M. Coyanis, C.E.J. van
Rensburg; Determination of the biodistribution of Au-compounds (intended as potential
chemotherapeutics) by the use of radiolabelled tracers.
2nd CONFERENCE on Imaging in Pre-clinical & Clinical Drug Development , Boston, USA, March
16th and 17th 2007.
J.R. Zeevaart,, D.R. Jansen , Z.I. Kolar, J.A. Peters, G.C. Krijger Towards a Radiopharmaceutical for
Palliative Treatment of Metastatic Bone Pain: a Novel 117mSn(SnII or SnIV)-Polymer Complex. 17th
International Symposium on Radiopharmaceutical Sciences, Aachen, Germany from 30 April – 4 May
2007.
Published in J. Lab. Comp. Radiopharm. 50, suppl. 1, S452, 2007.
J.R. Zeevaart , D.R. Jansen, Z.I. Kolar, J.A. Peters , G.C. Krijger , Progress made with potential 117m
Sn [Sn (II)] Radiopharmaceuticals aimed at treating secondary bone metastasis: Clarifying their in vivo
oxidation state. INORG 007 conference of the South African Chemical Institute, Club Mykonos, West
Coast 8-12 July 2007.
Invited lecture
F. Botelho, J.R. Zeevaart, D.R. Jansen, A. Turtio, A.M. Abrantes, Z.I. Kolar, M.A. Neves, F.H.A.
Scheneeweiss, G.C. Krijger, I.C. Dormehl. Comparison of the sizes of the potential therapeutic bone
agents, the polyphosphonate PEI-MP labeled with 117mSn and 186Re Dosimetric evaluations of the
polyphosphonate. European Association of Nuclear Medicine, Copenhagen, Denmark, 13-17 October
2007.
Published in Eur. J. Nucl. Med. Mol Imaging 34, suppl. 2, P354, 2007.
J.R.Zeevaart , J.M.Wagener , M. Neves , M.C. Costa , C. Rodrigues ,O. Knoesen , M.K. Dithebe , E.
Kilian , I. Cukrowski 99m Tc labeled biguanide derivatives: chemical speciation modeling thereof and
evaluation in vervets.
RheManTec International conference 19-24 November 2007 Bloemfontein.
D.R. Jansen, J.R. Zeevaart, Z.I. Kolar, K. Djanashvilik, J. A. Peters, G.C. Krijger, Towards
understanding the in vivo behaviour of potential (117m sn)sn-based radiopharmaceuticals aimed at
treating secondary bone metastasis.
South African Young Nuclear Professional Society: 6 November 2007: Alpha Conference Centre.
J.R. Zeevaart, D.R. Jansen, Z.I. Kolar, G.C. Krijger
Sn-117m PEI-MP (N,N’,N’trimethylenephosphonate-polyethyleneimine) as potential bone metastasis agent; Adsorption behavior
on hydroxyapatite.
6th International conference on Isotopes, 12-16 May 2008, Seoul, S. Korea.
C.C.P. Wagener, J.R. Zeevaart. The labeling of fluoroquinolones with F-18.
6th International conference on Isotopes, 12-16 May 2008, Seoul, S. Korea.
Z. Szucs, J. van Rooyen, J.R. Zeevaart. A possible in vivo generator 103Pd/103mRh - Recoil
considerations.
6th International conference on Isotopes, 12-16 May 2008, Seoul, S. Korea.
J.M. Wagener, J.R. Zeevaart, M.J. Nell, E. Kilian, M.A. Mamo, M. Layh, M. Coyanis, C.E.J. van
Rensburg.
Determination of the biodistribution of Au-compounds (intended as potential
chemotherapeutics) by the use of radiolabelled tracers.
6th International conference on Isotopes, 12-16 May 2008, Seoul, S. Korea.
S.M Rubow, F. De Klerk, E. Kilian, O. Knoesen, J.M. Wagener, J. Naidoo, J.R. Zeevaart.
EVALUATION OF BIODISTRIBUTION OF Tc-99m IgG FOR INFECTION IMAGING.
SA Society for Nucl. Med. 21-26 August 2008, Society of Nuclear Medicine, Windhoek, Namibia.
J. R. Zeevaart, D. R. Jansen, Z. I. Kolar, G. C. Krijger.Sn-117m PEI-MP (N,N’,N’trimethylenephosphonate-polyethyleneimine) as potential bone metastasis agent; Adsorption behaviour
on hydroxyapatite,; South African Society of Nuclear Medicine, 21-26 August 2008, Windhoek,
Namibia.
Z. Szucs , D. Steyn,E. Vermeulen, I.J. Van der Walt, K. Moodley, S. Verryn. J.R. Zeevaart. Separation
of 103Pd from metal Rh by thermal diffusion impossible. 4 NRC7 - SEVENTH INTERNATIONAL
CONFERENCE ON NUCLEAR AND RADIOCHEMISTRY Budapest, Hungary 24-29 August 2008
JR Zeevaart, JM Wagener, J Naidoo, O Knoesen, E Kilian, J Perils, SM Rubow,Technetium in the third
world setting.R&D in South Africa.
Int Symposium on Tc and Re, 7-10 Oct 2008, Port Elizabeth, South Africa
Invited Plenary lecture
J. Topkin, P. Mitchel, Z. Szucs, J.R. Zeevaart, New method for preparing 35S in the form as a sulfite to
be used as tracer in medical and physiological research Tracer 5, 2-6 November 2008, Tiradentes-MG,
Brazil.
W.G. Augustyn, J.B. Wagener, J.T. Nel, W. Meyer, J.R. Zeevaart, Z. Szucs, A. Goede. Nano@Necsa;
Nano Afica 2009 International Conference, 1-4 February 2009, CSIR conference centre, Pretoria, South
Africa.
D.R. Jansen, J.R. Zeevaart, O.D. Maslov, Z.I. Kolar, G.C. Krijger. More with less: Possible methods of
producing 117mSn with high specific activity, 18th International Symposium on Radiopharmaceutical
Sciences, 12-17 July 2009,Edmonton, Canada.
Published in J. Lab. Comp. Radiopharm. 52, suppl. 1, S452, 2009.
N.L. Dlamini, X.Y Mbianda, Z. Szucs, J.R.Zeevaart. Synthesis and characterization of bisphosphonate
conjugated carbon nanomaterials as a potential system for the treatment of secondary bone cancer.
Biomaterials-Africa 2009 Conference, 20-22 September 2009, Pretoria, South Africa.
D.R. Jansen, J.R. Zeevaart, O.D. Maslov, Z.I. Kolar, G.C. Krijger, More with less: Possible methods of
producing 117mSn with high specific activity, 18th International symposium on radiopharmaceutical
sciences conference in Edmonton, Canada, 12 – 17 July 2009.
J.R. Zeevaart, D.R. Jansen, K Gabanamotse, Z.I. Kolar, G.C. Krijger, An in vitro instead of in vivo
approach to develop 117mSn based bone-seeking radiopharmaceuticals as studied for Sn(II) and Sn(IV)
complexes of the polymer polyethyleniminomethyl phosphonic acid(PEI-MP); IAEA Technical
Meeting on Therapeutic Radiopharmaceuticals IAEA HQ, Vienna, Austria 16 to 20 November 2009.
N.L. Dlamini, X.Y. Mbianda, J.R. Zeevaart, Z. Szucs. Synthesis and characterisation of
bisphosphonates conjugated carbon nanotubes conjugates as a potential treatment for secondary bone
cancer. “ICS-UNIDO conference on Advanced diagnostics and drug-delivery at the nanoscale: state of
the art and possible applications to orphan diseases” 13-15 October 2009. Trieste, Italy.
Published in European Cells and Materials Vol. 19. Suppl. 1, 2010 (page 21) ISSN 1473-2262.
J.R. Zeevaart, Z. Szucs, S. Takacs, K Gabanamotse, N.V. Jarvis. In vivo generators – recoil and
conversion electrons considerations. RadChem 2010, Marianske Lazne, Czech republic,18-23 April
2010.
Invited lecture
J Suthiram, Kanyisa Mhlaba, Jan Rijn Zeevaart, Hendrik G Visser and Andreas Roodt.
International symposium on Technetium and other radiometals in chemistry and medicine, Brixen
Bressanone, Italy September 8 – 11, 2010.
Z Szucs, M Sathekge, B Marjanovic-Painter, JM Wagener, T Sellot, CCP Wagener, JR Zeevaart.
Synthesis and biodistribution of I-131 labelled 4-iodophenyl acetic acid. 10 th Congress of WNFMB,
Cape Town South Africa, 18 – 23 September 2010.
Published in World Journal of Nuclear Medicine – Volume 9, September 2010, S169
D.R. Jansen, J.R. Zeevaart, O.D. Maslov, Z.I. Kolar, G.C. Krijger More with less: Possible methods of
producing 117mSn with high specific activity
10 th Congress of WNFMB, Cape Town South Africa, 18 – 23 September 2010
Published in World Journal of Nuclear Medicine – Volume 9, September 2010, S41
J.R. Zeevaart, Z. Szucs, S. Takacs, DR Jansen, N.V. Jarvis. Recoil and conversion electrons
considerations of the 166Dy/166Ho in vivo generator. 2nd International Conference on the Application of
Radiotracers in Chemical, Environmental and Biological Sciences (ARCEBS 10) Kolkata, India, 8-13
November 2010.
Invited Plenary lecture
T Ebenhan, Z Szucs, K. Cimpeanu, D Dudu J.R. Zeevaart. Production of 68Ge from natural Zink by
cyclotron 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy (PRRNT)
THERANOSTICS – on the Way to Personalized Medicine, Zentralklinik Bad Berka, Germany – June
23-26, 2011.
Published in World Journal of Nuclear Medicine – Volume 10, June 2011, 73
T Ebenhan, N. Chadwick, T. Govender, H.G. Kruger, M. Sathekge, J.R. Zeevaart. Gallium-68 labelling
of NOTA-peptide conjugates for imaging infection – especially tuberculosis. 1st World Congress on
Gallium-68 and Peptide Receptor Radionuclide Therapy (PRRNT) THERANOSTICS – on the Way to
Personalized Medicine, Zentralklinik Bad Berka, Germany – June 23-26, 2011.
Published in World Journal of Nuclear Medicine – Volume 10, June 2011, 86
David R Jansen, Jan Rijn Zeevaart, Zvonimir I Kolar, Gerard C Krijger. An in vitro approach to
evaluate and develop potential 117m Sn based bone-seeking radiopharmaceuticals. 2nd Annual SA
Young Scientists Conference, 26 – 27 September 2011, Pretoria, South Africa
J Suthiram, HG Visser, JR Zeevaart, A Roodt. Crystallographic and kinetic studies of Re(I)-tricarbonyl
complexes with nN,O)-donar bidentate ligands. 2nd Annual SA Young Scientists Conference, 26 – 27
September 2011, Pretoria, South Africa
LC Sepini, DR Jansen, NV Jarvis JR Zeevaart. Towards establishing a blood plasma model for Lu(III).
2nd Annual SA Young Scientists Conference, 26 – 27 September 2011, Pretoria, South Africa
DR Jansen, LC Sepini, NV Jarvis, JR Zeevaart. Towards establishing a blood plasma model for Lu(III).
7th International Conference on Isotopes, Russia 4-8 September 2011.
C Driver, MI Parker, R Hunter, JR Zeevaart, The Development of a Gluco-Albumin Macromolecule as
a Specific Targeting Agent for Tumors SANHARP 2nd Annual postgraduate conference Cape Town
12-14 October 2011
S.M. Ferreira, A.M. Abrantes, L.F. Metello, J.R. Zeevaart, W.K.A. Louw, I.C. Dormehl, M.F.
Botelho. 188Re-PEI-MP as a potential agent for metabolic radiotherapy. European Association of
Nuclear Medicine, Birmingham, UK, 15-19 October 2011.
Published in Eur. J. Nucl. Med. Mol Imaging 38, suppl. 2, S213, 2011
B Kweto, DR Groot, J Suthiram, L Stassen, JR Zeevaart. The use of ammonium carbonate as lixiviant
in uranium leaching. ALTA 2012 conference on nickel/cobalt/copper, uranium & gold. 26 May- 2 June
2012, Perth, Australia
Published in Proceeding of Uranium sessions at ALTA 2012, ISBN: 978-0-9871262-4-5, p.139-149
T. Ebenhan T. Govender, G.H. Kruger, T. Pulker, V.Naidoo, J.R. Zeevaart and M. Sathekge. Synthesis
of 68Ga-NOTA-UBI30-41 and in vivo Biodistribution in vervet Monkeys towards potential PET/CT
Imaging of Infection. SNM 2012 annual meeting. 9-13 June 2012, SNM annual meeting 2012, Miami
beach, Florida, USA. Published in J. Nucl. Med. 2012 vol 53, suppl 1, P1520,
JR Zeevaart, ‘Radiospoorders – 'n visualiseringstegniek behulpsaam om medisyne(middels) vinniger te
ontwikkel’ Simposium 2012 of the ‘Suid Afrikaanse Akademie vir Wetenskap en Kuns’
21-22 June 2012, Pretoria, SA
Wagener J.M., Zinn C., Marjanovic-Painter B., Soni N., Perkins G., Sathekge M.M., Smith S.V,
Zeevaart J.R., Production of high specific activity 195mPt-Cisplatinum at Necsa for Phase 0 clinical trial
in healthy individuals subjects. 11th International Symposium on the Synthesis and Applications of
Isotopes and Isotopically Labelled Compounds (IIS XI), Heidelberg, Germany (9-13 September 2012)
Zeevaart J.R, Szucs Z. Takacs S., van Rooyen J. , Jansen D., Recoil and conversion electron
implications to be taken into account in the design of therapeutic radiopharmaceuticals utilising in vivo
generators. NRC-8, 16-20 September 2012, Como, Italy
Invited lecture
Ferreira S., Lranjo M., Abrantes A.M., Brito A.F., Metello L., Zeevaart J.R., Louw W., Dormehl I.,
Botelho M.F. A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and
188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma. 5th Annual meeting of the World
Molecular Imaging Congress, Dublin Ireland, 5-8 September 2012
Ebenhan T., Zeevaart J.R., Govender T., Kruger H.G., Pulker T., Sathekge M.M, Preparation of a
promising infection PET/CT imaging biomarker: 68Ga-labeled UBI30-41-1,4,7-triazacyclononane1,4,7-triacetic acid and feasibility study in a vervet monkey model. South African Society of Nuclear
Medicine, Parys, South Africa, 21-24 September 2012
Wagener J., ZinnC., Marjanovic-PainterB., Soni N., Perkins G. , Sathekge M. , Smith S.V. , Zeevaart
J.R., Production of high specific activity 195mPt-Cisplatin at NECSA for Phase 0 clinical trial in healthy
individuals subjects. South African Society of Nuclear Medicine, Parys, South Africa, 21-24
September 2012.
vd Westhuizen D., Wagener C.P., van Otterlo A.L., Sello T. The construction and configuration of a
“homemade” remote synthesis unit for the synthesis of radiolabelled [F-18] Fallypride tracer. South
African Society of Nuclear Medicine,Parys, South Africa, 21-24 September 2012.
J.R. Zeevaart, Two sides of the radiochemistry coin: Radiopharmaceuticals and Biological
Radiotracers. SACI Centenary Lectures, UP, Pretoria, SA, 28 September 2012
Invited lecture
Papers Refereed
7
Theses Refereed
5 MSc & 1 PhD
Editorship
Guest Editor, Journal of Radioanalytical and Nuclear Chemistry, 257, No.1, July 2003
Scientific committee
Chair and Member of 4ICI (4th International Conference on Isotopes) scientific advisory committee,
Cape Town, March 2002
Member of 5ICI (5th International Conference on Isotopes) scientific advisory committee, Brussels,
April 2005
Member of 6ICI (6th International Conference on Isotopes) scientific advisory committee, Seoul, May
2008