October 2010
CURRICULUM VITAE
Kevin Erreger
Research Instructor, Vanderbilt University
Department of Molecular Physiology & Biophysics
7124 Medical Research Building III
465 21st Ave S.
Nashville TN 37232
phone: 615 936 3890
email: kevin.erreger@vanderbilt.edu
Education
2004
Emory University
Ph.D. (Neuroscience)
1998
State University of New York at Buffalo
B.S. (Biophysics)
Employment Experience
2009-present Research Instructor
Vanderbilt University Department of Molecular Physiology & Biophysics
2005-2009
Research Fellow
Vanderbilt University Department of Molecular Physiology & Biophysics
Honors / Awards
2010
NIDA Frontiers in Addiction Research Early Career Investigator Travel Award
2005
Society for Neuroscience Chapters Postdoctoral Trainee Travel Award
1998-2003
George W. Woodruff Fellowship, Emory University
1998-2003
Predoctoral Fellowship, Howard Hughes Medical Institute
1998
summa cum laude
1994-1998
Dean’s list
1996
Grace W. Capen award
1995
Phi Eta Sigma honor society
1994
University Honors Scholarship
1
Research Support
Ongoing Research Support
9/2009-8/2011 K99 (NIDA) DA025716
“D2 Receptor and Food Restriction Regulation of Dopamine Release by Amphetamine”
01/2010-12/2011 Young Investigator Award (NARSAD)
“D2 Regulation of Syntaxin1A / Dopamine Transporter Association Modulates Non-Vesicular
Dopamine Release”
Previous Research Support
4/2006-3/2009 F32 (NIDA) DA020306
“Amphetamine Regulation of the Norepinephrine Transporter”
Teaching experience
2000 Teaching assistant, Systems Neuroscience, Emory University
2005 Lecturer, IGP Flex Time graduate student class, Vanderbilt University
2007 Lecturer, IGP Flex Time graduate student class, Vanderbilt University
2009-2010
Co-Director advanced graduate student class “Electrophysiology for
Biologists”, Vanderbilt University
Student trainees
1. Sabrina Doughty, graduate student Vanderbilt University.
2. Erica Bowton, graduate student Vanderbilt University.
3. Kari Myers, graduate rotation student Vanderbilt University.
4. Gregory Pask, graduate rotation student Vanderbilt University.
5. Olga Dadalko, graduate rotation student Vanderbilt University.
6. Erin Watt, graduate student Vanderbilt University.
7. Peter Hamilton, graduate student Vanderbilt University.
Editorial
Referee: Molecular Pharmacology, Journal of Neurochemistry, Neuropharmacology, Journal of
Neuroscience Methods.
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Invited Lectures
Johns Hopkins University. Baltimore, MD. Host: Dr. David Yue 2004.
Vanderbilt University. Nashville, TN. Host: Dr. Randy Blakely 2004.
NIEHS. Research Triangle Park, NC. Host: Dr. Jerry Yakel 2006.
Vanderbilt Univeristy. Nashville, TN. Molecular Physiology & Biophysics Seminar 2006.
NIAAA. Bethesda, MD. Host: Dr. David Lovinger 2007.
The Tennessee Physiological Society Annual Meeting. Nashville, TN 2009.
University of Alabama Birmingham. Host: Dr. Mary-Ann Bjornsti 2010.
State University of NY at Buffalo. Host: Dr. Margarita Dubocovich 2010.
Publications and Manuscripts
1) Zheng F., Erreger K., Low C-M, Banke T., Lee C.J., Conn P.J., & Traynelis S.F. (2001)
Allosteric interaction between the amino terminal domain and the ligand binding domain of
NR2A. Nature Neurosci 4: 894-901.
2) Mott D.D., Erreger K., Banke T.G., Traynelis S.F. (2001) Open Probability of homomeric
Murine 5-HT3A Serotonin Receptors Depends on Subunit Occupancy. J Physiol 535: 427443.
3) Erreger K., Banke T.G., Dravid S.M., Wyllie D.J.A., Traynelis S.F. (2005) Subunit-specific
gating controls recombinant rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and
temporal signaling properties. J Physiol 563:345-58.
4) Yuan H., Erreger K., Dravid S.M., Traynelis S.F. (2005) Conserved Structural and
Functional Control of NMDA Receptor Gating by Transmembrane Domain M3. J Biol Chem
280(33):29708-16.
5) Erreger K., Geballe M.T., Dravid S.M., Wyllie D.J.A., Snyder J.P., Traynelis S.F. (2005)
Mechanism of partial agonism at NMDA receptors for a conformationally restricted
glutamate analog. J Neurosci 25(34): 7858-66.
6) Erreger K., & Traynelis S.F. (2005) Allosteric interaction between zinc and glutamate
binding domains on NR2A causes desensitization of NMDA receptors. J Physiol 569(2):381393.
7) Dravid S.M., Erreger K., Yuan H., Nicholson K., Le P., Lyuboslavsky P.N., Almonte A.,
Murray E., Mosely C., Barber J., French A. Balster R., Murray T., & Traynelis S.F. (2007)
Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. J
Physiol 581(2):107-28.
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8) Erreger K., Geballe M.T., Kristensen A.S., Chen P.E., Hansen K.B., Lee C.J., Le P.,
Lyuboslavsky P.N, Wyllie D.J.A, Synder J.P, Traynelis S.F. (2007) Subunit-specific agonist
activity for glutamate analogs at NR2A, NR2B, NR2C, and NR2D N-methyl-D-aspartate
glutamate receptors. Mol Pharm 72(4):907-20.
9) Chen P.E., Geballe M.T., Katz E., Erreger K., Livesey M., O’Toole K.K., Le P., Lee C.J.,
Snyder J.P., Traynelis S.F., Wyllie D.J.A. (2007) Allosteric modulation of glycine potency in
rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in
Xenopus laevis oocytes. J Physiol 586(1):227-245.
10) Erreger K. & Traynelis S.F. (2008) Zinc inhibition of NR1/NR2A NMDA channels. J
Physiol 586(3):763-78.
11) Erreger K., Grewer C., Javitch J.A., Galli A. (2008) Currents in response to rapid
concentration jumps of amphetamine uncover novel aspects of human dopamine transporter
function. J Neurosci 28(4):976-89.
12) Binda F., Dipace C., Bowton E., Robertson S.D., Lute B.J., Fog J.U., Zhang M., Sen N.,
Gnegy M.E., Gether U., Javitch J.A., Erreger K., Galli A. (2008) Syntaxin 1A interaction
with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol Pharm
74(4):1101-8.
13) Bowton E., Saunders C., Erreger K., Sakrikar D.J., Matthies H.J., Sen N., Jessen T.,
Colbran R.J., Caron M.G., Javitch J.A., Blakely R.D., Galli A. (2010) Dysregulation of
dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux
associated with attention-deficit hyperactivity disorder. J Neurosci 30(17):6048-57.
14) Erreger K., Davis A.R., Robertson S.D., Matthies H.J., Watt E.E., Saunders C., Vaughan R.A.,
West A.R., Greig N.H., Niswender K.D., Galli A. (2010) Glucagon-like peptide-1 (GLP-1) inhibits
neuronal nitric oxide synthase and increases dopamine transporter surface levels in the striatum. (in
preparation)
Reviews
1) Erreger K., Chen P.E., Wyllie D.J.A., Traynelis S.F. (2004) Glutamate receptor gating. Crit
Rev Neurobiol 16(3):187-224.
Book Chapters
1) Erreger K., Matthies H.J., Galli, A., Saunders C. (2010) Neurotransmitter Transporters.
Encyclopedia of Biological Chemistry 2nd Edition (in preparation).
Abstracts
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1) Erreger K. & Jaeger D. (1999) The response of neurons of the deep cerebellar nuclei to lip
stimulation in the anesthetized rat. Soc. Neuroci. Abstr.
2) Erreger K., Zheng F., Traynelis S.F. (2001) An allosteric interaction between the glutamate
and zinc binding sites causes fast desensitization of NR1/NR2A NMDA receptors. Soc.
Neurosci. Abstr.
3) Erreger K., Zheng F., Traynelis S.F. (2002) An allosteric interaction between the glutamate
and zinc binding sites causes fast desensitization of NR1/NR2A NMDA receptors. Southeast
Nerve Net, Atlanta GA.
4) Erreger K. & Traynelis S.F. (2002) Zinc and protons similarly modulate single-channel
kinetics of NMDA receptors. Soc. Neurosci Abstr.
5) Erreger K. & Traynelis S.F. (2003) Zinc inhibition of NR1/NR2A NMDA receptors. Zinc
Signals 2003, Cayman Islands.
6) Erreger K., Wyllie D.J.A., Banke T.G., Lee C.J., Traynelis S.F. (2003) Activation of
NR1/NR2A and NR1/NR2B NMDA receptors. Soc. Neurosci. Abstr.
7) Erreger K., Chen P.E., Lee C.J., Wyllie D.J.A., Traynelis S.F. (2004) The S1 region of NR2
controls the subunit-specific activation of NMDA receptors by SYM2081. Soc. Neurosci.
Abstr.
8) Yuan H., Erreger K., Chen P.E., Le P., Traynelis S.F. (2004) Covalent modification of an
engineered cysteine in M3 locks open NMDA channels. Soc. Neurosci. Abstr.
9) Traynelis S.F., Dravid S.M., Erreger K., Banke T.G, Wyllie D.J.A. (2004) Open probability
and kinetic properties of individual NR1/NR2A NMDA receptors activated by synaptic-like
glutamate concentration jumps. Soc. Neurosci. Abstr.
10) Lyuboslavsky P.N., Kristensen A.S., Dravid S.M., Erreger K., Traynelis S.F. (2005) Mutational
analysis of the NR2A subunit: identification of structural determinants for allosteric coupling
between zinc, protons, and glutamate. Soc. Neurosci. Abstr.
11) Yuan H., Erreger K., Dravid S.M., Traynelis S.F. (2005) Single channel properties and differential
effect of channel blockers after MTSEA-Modification of A7C mutant NMDA receptors. Soc.
Neurosci. Abstr.
12) Wyllie D.J.A., Erreger K., Geballe M.T., Dravid S.M., Snyder J.P., Traynelis S.F. (2005)
Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate
analog. Soc. Neurosci. Abstr.
13) Traynelis S.F., Erreger K., Lee C.J., Chen P.E., Le P., Lyuboslavsky P.N., Wyllie D.J.A. (2005)
Subunit-specific agonist activity for glutamate analogs at NR2A, NR2B, NR2C, and NR2D NMDA
subunits. Soc. Neurosci. Abstr.
14) Erreger K., Javitch J.A., Galli A. (2005) Amphetamine induces a rapidly desensitizing inward
current through the human dopamine transporter. Soc. Neurosci. Abstr.
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15) Chen P.E., Erreger K., Livesey M., Traynelis S.F., Wyllie D.J.A. (2006) Glycine potency among
recombinant N-methyl-D-aspartate receptor subtypes is influenced by the S2 glutamate binding
region of the NR2 subunit. Forum of European Neuroscience.
16) Geballe M.T., Erreger K., Lee C.J., Traynelis S.F., Snyder J.P. (2006). Understanding agonism in
the NMDA receptor: comparing NR2A and NR2D using MD. American Chemical Society Meeting.
17) Erreger K., Javitch J.A., Galli A. (2006) Substrate-induced currents through the human dopamine
transporter. Soc. Neurosci. Abstr.
18) Traynelis S.F. & Erreger K.(2006) Zinc inhibition of NR1/NR2A N-Methyl-D-Aspartate receptor
channels. Soc. Neurosci. Abstr.
19) Chen P.E., Erreger K., Livesey M., O’Leary T., O’Toole K.K., Traynelis S.F., Wyllie D.J.A. (2006)
The role of functional domains of NMDA NR2A and NR2D receptor subunits in influencing glycine
potency in recombinant NMDA receptors. Soc. Neurosci. Abstr.
20) Geballe M.T., Kristensen A.S., Erreger K., Chen P.E., Lyuboslavsky P., Le P., Wyllie D.J.A.,
Snyder J.P., Traynelis S.F. (2006) Agonist binding to NR2A and NR2D NMDA receptor subunits.
Soc. Neurosci. Abstr.
21) Erreger K., Javitch J.A., Galli A. (2006) Substrate-induced currents through the human dopamine
transporter. Gordon Research Conference on Membrane Transport
22) Geballe M.T., Hansen K.B., Erreger K., Lee C.J., Kristensen A.S., Chen P.E., Wyllie D.J.A.,
Snyder J.P., Traynelis S.F. (2007) Subunit-specific binding and agonist activity of glutamate and
SYM2081 at NR2A and NR2D containing N-methyl-D-aspartate glutamate receptors. Soc. Neurosci.
Abstr.
23) Erreger K., Grewer C., Javitch J.A., Galli A. (2007) Currents in response to rapid concentration
jumps of amphetamine uncover novel aspects of human dopamine transporter function. Soc.
Neurosci. Abstr.
24) Dipace C., Binda F., Bowton E., Lute B.J., Gnegy M.E., Gether U., Javitch J.A., Erreger K., Galli
A. (2008) Syntaxin1A promotes amphetamine-induced dopamine efflux through the dopamine
transporter. Soc. Neurosci. Abstr.
25) Bowton E., Saunders C., Erreger K., Sakrikar D.J., Sen N., Jessen T., Colbran R.J., Blakely R.D.,
Galli A. (2008) The dopamine transporter variant A559V mediates anomalous dopamine efflux
through increased N-terminal phosphorylation. Soc. Neurosci. Abstr.
26) Bowton E., Saunders C., Erreger K., Sakrikar D.J., Sen N., Jessen T., Colbran R.J., Caron M.G.,
Javitch J.A., Blakely R.D., Galli A. (2009) Dysregulation of dopamine transporters via dopamine D2
autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity
disorder. Soc. Neurosci. Abstr.
27) Erreger K., Davis A.R., Robertson S.D., Matthies H.J., Watt E.E., Saunders C., Vaughan R.A.,
West A.R., Greig N.H., Niswender K.D., Galli A. (2010) Regulation of dopamine transporter in the
striatum by the glucagon-like peptide-1 (GLP-1) receptor Soc. Neurosci. Abstr.
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