Drug Information Sheet("Kusuri-no-Shiori")
Internal
Published: 12/2012
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval
details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is
important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients
should understand their medication and cooperate with the treatment.
Brand name:MINIRINMELT OD Tablet 120mcg [medication for nocturnal
enuresis]
Active ingredient:Desmopressin acetate hydrate
Dosage form:white tablet, diameter: 12 mm, thickness: 3 mm
Print on wrapping:120, ミニリンメルト OD 錠 120μg
Effects of this medicine
This medicine has actions similar to "vasopressin", an antidiuretic hormone to control urine volume, secreted from
the pituitary gland in the brain. It is a tablet which promotes reabsorption of water in renal tubules of the kidney to
concentrate urine and consequently prevents nocturnal enuresis (bed-wetting) associated with secretion defect of
vasopressin during the night.
It is usually used in the treatment of nocturnal enuresis caused by decreased urine osmolarity or decreased specific
gravity of urine.
Before using this medicine, be sure to tell your doctor and pharmacist
・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have: hyponatremia, habitual or psychogenic polydipsia, a history of cardiac failure, syndrome of
inappropriate secretion of antidiuretic hormone or renal disorder.
・If you are pregnant or breastfeeding.
・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal
effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
・Your dosing schedule prescribed by your doctor is<<
to be written by a healthcare professional>>
・In general, take 1 tablet (120 mcg of desmopressin) at a time, once daily, before going to bed. If the effect is
insufficient, the dose will be increased to 2 tablets (240 mcg) at a time. Strictly follow the instructions.
・Take this medicine without water since it melts quickly under the tongue.
・Diet may affect the absorption of this medicine. Consult with your doctor or pharmacist regarding the timing of meal
and drug administration.
・Urinate before going to bed, then, take this medicine.
・If you miss a dose, take a dose before going to bed on the next day. You should never take two doses at one time.
・If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
・Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
・Follow the lifestyle guidance instructed by your doctor.
・From after supper until the next morning, follow the instructions of your doctor and try not to drink water as much
as possible. Do not take this medicine if you drank water more than the amount instructed.
Possible adverse effects of this medicine
The most commonly reported adverse reactions include abdominal pain, malaise, headache, dry mouth, abnormality
of hepatic function, loss of appetite, nausea, facial edema, vomiting, fever, insomnia and dizziness. If any of these
symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in
brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
・general malaise, headache, nausea [water intoxication]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your
doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
・Take out the tablet from the package sheet immediately before taking it since it is susceptible to water and light.
・In taking out the tablet from the package sheet, peel off the back sheet and slowly push out the tablet with your
finger pad. If the tablet is cracked or split, take a whole tablet including the fragments.
・Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
・Discard the remainder. Do not store them. Ask the pharmacist or healthcare facility how to discard them.
For healthcare professional use only
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For further information, talk to your doctor or pharmacist.