Supplementary TABLE 1.
Summary of available information on the hypoxia-induced microRNAs (the
supplementary references are indicated).
Mir-7
Mir-15a
mir-21
mir-23a
Mir-23b
Mir-24
Mir-26a
Mir-26b
Mir-27a
Mir-30b
Mir-30d
Mir-93
Mir-103
Mir-106a
Mir-107
Mir-125b
Mir-148a
Mir-148b
Mir-155
Mir-181a
Mir-181b
Mir-181c
Mir-191
Mir-192
Mir-195
Mir-200a
Mir-210
Mir-213
Mir-214
Mir-373
Let-7-i
Upregulated in pancreatic and stomach cancer.1
Downregulated in Chronic Lymphocytic Leukemia and pituitary adenoma, induced in the
regenerating mouse pancreas.2,3,4
Upregulated in pancreas cancer, glioblastoma, breast cancer, colon cancer, lung cancer, prostate
cancer, stomach cancer, hepatocellular carcinoma, uterine leiomyomas, ovarian cancer,
cholangiocarcinoma, and cardiac hypertrophy.1,5-12
Upregulated in hepatocellular carcinoma, bladder cancer, breast cancer, pancreatic cancer, stomach
cancer, and in cardiac hypertrophy.1,5,7,12,13,14
Upregulated in hepatocellular carcinoma, bladder cancers, Human uterine leiomyomas, breast
cancer, pancreas cancer, and in cardiac hypertrophy. 1,5,7,9,12,13,14
Upregulated in hepatocellular carcinoma, breast cancer, lymphoma, colon cancer, pancreas cancer,
stomach cancer, down in prostate cancer, inhibits erythropoiesis; upregulated in cardiac
hypertrophy.1,7,12,13,15
Downregulated in human thyroid anaplastic carcinomas, modulates late osteoblasts differentiation,
up in pancreas cancer. 1,16,17
Upregulated in bladder cancers, up in pancreas cancer. 1,14
Upregulated in renal cell carcinoma, Human uterine leiomyomas, pancreas cancer, prostate
cancer.1,9,14
Upregulated in pancreas cancer1
Upregulated in pancreas cancer, prostate cancer, down in human thyroid anaplastic carcinomas,
chronic lymphocytic leukemia, lung cancer1,16,18
Upregulated in hepatocellular carcinoma, pancreas cancer, prostate cancer, down in cardiac
hypertrophy.1,12,13
Upregulated in bladder cancers, pancreatic cancer, stomach cancer. 1,5,14
Up in lung, gastric, colon, pancreas and prostate cancer, hepatocellular carcinoma, T-lymphoma, Tcell leukemia, neuroblastoma, down during megakaryocytopoiesis. 1, 13,19,20,21,22
Upregulated in colon cancer, pancreas cancer, stomach cancer 1,5
Up in pancreas cancer, stomach cancer, up in cardiac hypertrophy, down in human thyroid
anaplastic carcinomas, human ovarian cancer, breast cancer, prostate cancer. 1,5,710,12,16
Upregulated in lung cancer, prostate cancer, downregulated in pancreatic cancer. 1,5
Upregulated in lung cancer, prostate cancer, downregulated in pancreatic cancer.1,5
Upregulated in bad prognosis in Chronic lymphocytic leukemia and lung cancer; upregulated in
breast cancer, Hodgkin lymphoma, pediatric Burkitt lymphoma, colon cancer, lung cancer;
downregulated in pancreas cancer (1), upregulated in pancreas cancer (5); induced during the
macrophage inflammatory response.1,5,7,18,23,24
Upregulated in breast cancer, pancreas cancer, down in chronic lymphocytic leukemia,
glioblastoma; correlates with morphological sub-class of acute myeloid leukaemia; role in T cell
development.1,5,7,18,25,26,27,28
Upregulated in acute lymphoblastic leukemia, breast cancer, pancreas cancer, prostate cancer,
downregulated in glioblastoma, downregulated in cardiac hypertrophy. 1,5,7,12,,25,29
Upregulated in pancreas cancer, downregulated in glioblastoma.1,5,25
Upregulated in stomach cancer, colon cancer, lung cancer, pancreas cancer, prostate cancer. 1
Up in stomach cancer, pancreas cancer, upregulated in diabetic kidney glomeruli.1,30
Up in Chronic lymphocytic leukemia, up in cardiac hypertrophy, higher in the regenerating mouse
pancreas as compared to embryonic day, up in prostate cancer. 1,4,12,29
Upregulated in human ovarian cancer.10
Upregulated in breast cancer, lung cancer, pancreas cancer, upregulated in patients with
preeclampsia and small for gestational age (SGA), downregulated in ovarian cancer. 1,5,31,32
Upregulated in breast cancer, colon cancer, pancreas cancer. 1.5,7
Upregulated in pancreas cancer, prostate cancer, stomach cancer, up in cardiac hypertrophy;
modulates Hedgehog signaling to specify muscle cell fate.1,12,33
Upregulated in testicular germ-cell tumor cell lines.34
Upregulated in breast cancer.7
Supplementary Table 2.
Summary of available information on the hypoxia-repressed microRNAs (the supplementary
references are indicated).
.
4
Mir-15b
Mir-16
Mir-20a
Mir-20b
Mir-26b
Mir-29b
Mir-30b
Mir-101
Mir-122a
Mir-141
Mir-195
Mir-197
Mir-224
Let-7-a
Let-7-c
Let-7-d
Let-7-f
Let-7-g
Upregulated in the regenerating mouse pancreas.
Downregulated in Chronic Lymphocytic Leukemia, pituitary adenoma and breast cancer;
upregulated in lung cancer, prostate cancer, pancreas cancer; upregulated in the regenerating mouse
pancreas.1,2,3,4,7
Upregulated in hepatocellular carcinoma, colon cancer, pancreas cancer, prostate cancer,
downregulated during megakaryocytopoiesis.1,13,22
Upregulated in hepatocellular carcinoma, T cell leukemia, downregulated during
megakaryocytopoiesis. 13,20,22
Upregulated in bladder cancer, up in pancreas cancer. 1,14
Upregulated in breast cancer, colon cancer, pancreas cancer and prostate cancer, downregulated in
cholangiocarcinoma, human uterine leiomyomas; role in insulin resistance.1,7,9,11,35
Upregulated in pancreas cancer1
Upregulated in megakaryoblastic leukemic cell lines, up in prostate cancer. 1,22
Downregulated in hepatocellular carcinoma, upregulated in breast cancer. 7,13
Upregulated in human ovarian cancer, cholangiocarcinoma, lung cancer. 1,10,11
Up in Chronic lymphocytic leukemia, up in cardiac hypertrophy, higher in the regenerating mouse
pancreas as compared to embryonic day, up in prostate cancer. 1,4,12,29
Downregulated in human uterine leiomyomas.9
Downregulated in breast cancer, Upregulated in pancreas cancer. 1,7
Downregulated in lung cancer, chronic lymphocytic leukemia, breast cancer, prostate cancer.
Upregulated in hepatocellular carcinoma.1,7,13,18
Downregulated in prostate cancer, role in liver oncogenesis. 1,36
Downregulated in breast cancer, upregulated in prostate cancer.1,7
Upregulated in renal cell carcinoma, downregulated in breast cancer, promotes angiogenesis.7,14,37
Upregulated in lung cancer.1
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