BIOGRAPHICAL SKETCH Provide the following information for all key personnel. Follow the sample format for each person found in Biosketch Sample. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Tibshirani, Robert J. Professor of Health Research and Policy EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE (if applicable) YEAR(s) University of Waterloo, Ontario, Canada B.Sc. 1979 University of Toronto, Toronto, Canada Stanford University, Stanford, CA, USA M.Sc. Ph.D. 1980 1984 INSTITUTION AND LOCATION FIELD OF STUDY Statistics & Computer Science Statistics Statistics A. Positions and Honors. Professional Experience 1985–1989 Assistant Professor, (NSERC University Research Fellow), Department of Preventive Medicine and Biostatistics and Department of Statistics, University of Toronto 1989–1994 Associate Professor (NSERC University Research Fellow) Department of Preventive Medicine and Biostatistics and Department of Statistics, University of Toronto 1994–1998 Professor, Department of Public Health Science, and Department of Statistics, University of Toronto 1998–Present Professor, Department of Health Research and Policy and Department of Statistics, Stanford University Selected Professional Duties and Committees 1995–1999 Associate Editor, Statistical Science 1995–1996 Chair, IMS Committee on Computerization 1995–1997 Associate Editor, Cancer Journal Statistics 1998–1999 Associate Editor, Annals of Statistics Selected Honors and Awards 1993 Fellow of the American Statistical Association 1994 J. Guggenheim Foundation Fellowship 1994 Fellow of the Institute of Mathematical Statistics 1996 COPSS (Committee of Presidents of Statistical Societies) (worldwide) Award for contributions to Statistics before age 40 1997 NSERC E.W.R. Steacie Fellow 2000 CRM-SSC (Statistical Society of Canada) Prize B. Selected peer-reviewed publications (in chronological order). 1. 2. 3. 4. 5. Witten D, Tibshirani R. (2008) Testing significance of features of lassoed principal components. Annals Applied Statistics 2:986-1012. Paul D, Bair E, Hastie T, Tibshirani R. (2008) “Preconditioning” for feature selection and regression in high-dimension problems. Annals Applied Statistics 36:1595-1618. Tibshirani R. (2008) Discussion of Treelets-An adaptive multi-scale basis for sparse unordered data. Annals Applied Statistics 2:482-483. Holger H, Tibshirani R. (2008) A study of pre-validation. Annals Applied Statistics 2:643-664. Efron B, Hastie T, Tibshirani R. (2007) Discussion: The Dantzig selector: statistical estimation when p is much larger than n. Annals Applied Statistics 6:2358-2364. Page ____ Biographical Sketch 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. Efron, B, TIbshirani R. (2007) On testing the significance of sets of genes. Annals Applied Statistics 1:107-129. Tibshirani R, Hastie T. (2007) Outlier sums for differential gene expression analysis. Biostatistics. 8(1):2-8. Guo Y, Hastie T, Tibshirani R. (2007) Regularized linear discriminant analysis and its application in microarrays. Biostatistics. 8:86-100. Park MY, Hastie T, Tibshirani R. (2007) Averaged gene expressions for regression. Biostatistics. 8:212-227. Zhao H, Ljungberg B, Grankvist K, Rasmuson T, Tibshirani R. Brooks JD. (2006) Gene expression profiling predicts survival in conventional renal cell carcinoma. PLoS Med. 3(1). Tibshirani, R. (2006) A simple method for assessing sample sizes in microarrary experiments. BMC Bioinformatics 7:106. Taylor, J. Tibshirani, R., Efron, B. (2005) The ``Miss rate'' for the analysis of gene expression data. Biostatistics 6:111-117. Lossos IS, Czerwinski DK, Alizadeh AA, Wechser MA, Tibshirani R, Botstein D, Levy R. (2004) Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. N. Engl. . Med. 29:350(18):1828-1837. Rieger KE, Hong WJ, Tusher VG, Tang J, Tibshirani R, Chu G. (2004) Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Proc. Natl. Acad. Sci. U S A. 27:101:6635-6640. Bair E, Tibshirani R. (2004) Semi-supervised methods to predict patient survival from gene expression data. PLoS Biol. 2(4):E108. Bullinger L, Dohner K, Bair E, Frohling S, Schlenk RF, Tibshirani R, Dohner H, Pollack JR. (2004) Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N. Engl. J. Med. 15:350:1605-1616. Storey JD, Tibshirani R. (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A. 5;100:9440-9445. Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lonning PE, Brown PO, Borresen-Dale AL, Botstein D. (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl. Acad. Sci. U S A. 8;100:8418-8423. Wang Y., Liu CL, Storey JD, Tibshirani R., Herschlag D., Brown P.O. (2002) Precision and functional specificity in mRNA decay. Proc. Natl. Acad. Sci. USA. 99:5860–5865. Tibshirani R., Efron, B. (2002) Pre-validation and inference in microarrays. Statistical Applications in Genetics and Molecular Biology. 1:1–20. Tibshirani R, Hastie T, Narasimhan B, Chu G. (2002) Diagnosis of Multiple Cancer Types by Shrunken Centroids of Gene Expression. Proc. Natl. Acad. Sci. USA. 99(10):6567-6572. Hastie T, Tibshirani R, Botstein D, Brown P. (2001) Supervised harvesting of expression trees. Genome Biol. 2(1): RESEARCH0032. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn, M., Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lonning E, Borresen-Dale, A-L. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA. 98:10869–10874. Tusher VG, Tibshirani R, Chu G. (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci .USA 98:5116–5121. Hastie T, Tibshirani R, Friedman J. (2001) The Elements of Statistical Learning: Data Mining, Inference and Prediction, Springer-Verlag, New York. Hastie T, Tibshirani R, Eisen M, Alizadeh A, Levy R, Staudt L, Chan Wing C, Botstein D, Brown P. (2000) Identifying distinct sets of genes with similar expression patterns via “Gene Shaving.” Genome Biol. 1:1–21. Page ____ Biographical Sketch C. Research Support. ACTIVE 8R01 EB001988 (Johnstone, Hastie) 9/14/07 – 6/30/11 1.8 calendar NIH $1,000,000 New Statistical Methods for Medical Signals and Images Goals: This methodological grant proposes to develop methods for analyzing microarray data and medical data that comes in the form of signals or images such as MRI and FMRI scans, and protein mass spec. DMS 0404594 (Tibshirani) 8/1/04 - 7/31/10 1.44 calendar NSF $78,460 Flexible and Adaptive Statistical Methods Goals: In this grant I propose to develop statistical methods for model selection and combination, and write a textbook on modern statistical learning methods. R01 CA112016 (Pollack) 4/19/06 – 2/28/11 0.6 calendar NIH $174,267 Gene Amplification and Deletion in Pancreatic Cancer Goals: The major goal of this project is to characterize gene amplifications and deletions in pancreatic cancer, to understand their role in tumor development and progression, and to investigate their utility as therapeutic targets. N01 HV 28183 (Nolan) 9/30/02 - 9/29/09 0.6 calendar NIH, NHLBI $1,320,750 Proteomic Analysis of Blood Components in Autoimmune Disease Goals: The major goal of this project is to develop proteomic approaches to studying autoimmune disease. The $1,350,763 is the total direct cost for our Proteomic Center. Subcontract (Levy) The Leukemia and Lymphoma Society Immunological Signals and the Control of Lymphoma Goals: Studies of cell signaling and lymphoma. 10/1/05 - 9/30/10 $1,042,000 0.24 calendar A140034 (Greenberg) The Rockefeller University Hepatitis C: Studies of Immunity and Pathogenesis Goals: Assisting in microarray analysis. 7/1/05 - 6/30/10 $169,892 0.72 calendar 8-PCA034233F (Levy) 7/17/06 - 3/31/11 2.4 calendar NIH $1,086,564 Clinical and Laboratory Studies of Malignant Lymphomas Goals: Study the biology of and treatment for diffuse large cell lymphoma and follicular lymphoma. U54 GM62119 (Davis) 9/31/08 - 8/31/09 0.6 calendar Massachusetts General Hospital $1,007,774 Inflammation and the Host Response to Injury Goals: Study the genomic and proteomic properties of inflammation and the host response to injury. PENDING Subcontract (Van de Rijn) 7/1/09 - 6/30/12 Palo Alto Institute for Research Education $396,916 Discovery of Gene Expression Signatures in Cancer Stroma Page ____ 0.84 calendar Biographical Sketch