Curriculum Vitae Name: Maria Teresa (Maite) Bezem Addres: Fagernes 19, N-5043 Bergen, Norway Telephone: +47 98 80 11 99 Email: Maite.Bezem@uib.no Birthday: May 16 1988 Marital status: Married to Yrjan Christopher Blente and mother of Sølve Elias Bezem Blente (born August 11 2013) Education: 20122010-2012: 2007-2010: 2005-2007: 2004-2005: Ph.D. candidate, University of Bergen, Norway Master degree in nanoscience, University of Bergen, Norway Grade A on master thesis in nanomedicine about the use of nanoparticles for stabilizing the enzyme tyrosine hydroxylase Bachelor degree in nanotechnology, University of Bergen, Norway A multidisciplinary undergraduate program focusing on the nano scale and addressing both research and industry, finished in two and a half year and was the first student to graduate from the nanotechnology program International Baccalaureate, Bergen Katedralskole (high school), Norway Mathematics, physics, Norwegian and English taken at high level and chemistry, economics and French taken at standard level Première Scientifique, Lycée George de la Tour, Nancy, France First year of high school as an exchange through Youth for Understanding Work experience: 20122012: 2011: 2009-2011: 2008-2011: 2007-2008: Research fellow as Ph.D. candidate with 75% research and 25% teaching at the Faculty of Medicine, University of Bergen, Norway Engineer, Helse Bergen (hospital health care), Norway 5 months 50% employment for laboratory work done for the neurological department at Haukeland University Hospital Scientific assistent in the laboratory course NANO200 “Nanoprocesses and nanomaterials” with responsibility for the exercises on nanoparticle synthesis, University of Bergen, Norway Teacher for a class at SommerViten, a summer camp arranging courses in Bergen, Norway about science and technology for children aged 9 to 15. Tutor at the department of mathematics in the courses MAT101 “Elementary Calculus I” and MAT112 “Calculus II” at University of Bergen, Norway with responsibility for small groups, large seminars and correction of handed-in assigments Holiday jobs at BERLE på Bryggen, a souvenirshop, Bergen, Norway. Honorary posts: 20152015-2016: 2015-2016: 2011-2012: 2009-2011: 2009: 2008-2009: 2005-2009: 2007-2008: Founder and first deputy board member of the cooperation “Biskopshavn Kirkes barnehage SA” – a nursery for children aged 0 – 6 years Member of the appointment committee working on behalf of the faculty board evaluating the appointments of temporary employees at the Faculty of Medicine, University of Bergen, Norway Board member at the faculty board as the representative of the temporary employees at the Faculty of Medicine, University of Bergen, Norway Board member in the Students Sailing Club of Bergen President of the Students Sailing Club of Bergen Vice-president of the Students Sailing Club of Bergen Founder and treasurer of Nanos, the association for nanotechnology students at the University of Bergen Recruitment responsible in the board for Youth for Understanding in the region Hordaland, Norway Student representative in the board for the nanotechnology and nanoscience programs Teaching and supervising experience: 2014-2015: 2015: 2015: 2015: 2012-15: Spring 2011: 2011: 2009-2011: 2008-2011: Assistant supervisor for Fredrik Gullaksen Johannessen during his 60 ECTS master thesis project called “Investigation of the efficiency of different nanoparticle preparations for the in vitro and in vivo stabilization of tyrosine hydroxylase” Two-hours lecture in the course BMED325 “Cellular Biochemistry and Nanobiochemistry” about nanoparticles’ synthesis and their applications in biomedical research, University of Bergen, Norway. Scientific assistent in the laboratory course MEDOD1 “First semester Medicine and Dentistry” with responsibility for the exercises on lipids and enzymes, University of Bergen, Norway Scientific assistent in the laboratory course FARM301 “Pharmaceutical research methods” with responsibility for DNA and protein purification and analysis, University of Bergen, Norway. Scientific assistent in the laboratory course BIOBAS “Basic biological sciences for medical students” supervising the exercises on amino acids, carbohydrates and DNA, University of Bergen, Norway. Supervisor for bachelor student Elisabeth Elje in NANO100 lab project (10 ECTS) called “Enzyme replacement therapy for Parkinson’s disease”. Scientific assistent in the laboratory course NANO200 “Nanoprocesses and nanomaterials” with responsibility for the exercises on nanoparticle synthesis, University of Bergen, Norway. Teacher for a class at SommerViten, a summer camp arranging courses in Bergen, Norway about science and technology for children aged 9 to 15. Tutor at the department of mathematics in the courses MAT101 “Elementary Calculus I” and MAT112 “Calculus II” at University of Bergen, Norway with responsibility for small groups, large seminars and correction of handed-in assigments. Courses: Spring 15: Summer 14: Autumn 13: Autumn 12: Autumn 10: 11th course in confocal microscopy at the Molecular Imaging Center, University of Bergen, Norway. Five-week Summer School for Silicon Nanotechnology by Prof. Michael J. Sailor at University of California, San Diego, United States. Atomic force microscopy by Anne Baumann from the National Graduate School BioStruct at University of Bergen, Norway. Protein expression and purification and analysis course by Gunther Stier from EMBL Heidelberg and Gilles Trave from University of Strasbourg, at University of Bergen, Norway. Safety course for radioactive material, Health and Safety department, University of Bergen, Norway. Awards, scholarships and other: March 15: Scholarship of NOK 55 000 by the Meltzer foundation for the project “Siliconbased nanoparticles for the treatment of Parkinson’s disease”, University of Bergen, Norway. Autumn 14: Scholarship from the National Graduate School BioStruct of NOK 84 000 for a six-months research stay as a visiting scholar while working on the project “Porous Silicon Particles for Sustained Drug Delivery” in the laboratory of Prof. Michael J. Sailor at University of California, San Diego, United States. March 13: Scholarship of NOK 44 000 by the Meltzer foundation for the project “The uptake of tyrosine hydroxylase in cells and crossing of blood-brain barrier by biologically degradable nanoparticles”, University of Bergen, Norway. Autumn 11: Part of the winning team at Sci – Preneurship contest with the best business idea during the innovation camp arranged by Young Achievement, Junior Enterprise, Brussels, Belgia. Spring 11: Scholarship of NOK 8 800 by Lina Asbjørnsen’s foundation for brilliant female science students at the faculty of mathematics and natural sciences, University of Bergen, Norway. Spring 10: Named the “National Student of the Year in Technology” in 2010 by Universum Awards and therefore given a scholarship of NOK 20 000 by FMC Technologies, Oslo, Norway. Spring 10: Scholarship of NOK 7 000 by Lina Asbjørnsen’s foundation for brilliant female science students at the faculty of mathematics and natural sciences, University of Bergen, Norway. 2008: Participation by selection in the TV-series ”The Future Detectives” – a documentary series produced by Bastard Film A/S in Denmark and subsidized by the EU to promote science for youth between 15 and 25 years old. Spring 2008: Norway’s representation in Intel International Science and Engineering Fair (ISEF) in Atlanta, USA with my project on Population Models. Autumn 2007: Norway’s representation in the 19th EU Contest for Young Scientists in Valencia, Spain with my project on Population Models. Summer 07: Participation by invitation in the European Space Camp at Andøya Rocket Range, Norway. Spring 07: Winner of the Norwegian Young Scientist Contest with my extended essay on Population Models – an evaluation of mathematical models by applying them to data of the cod stock in the Barents Sea, Oslo, Norway. Price money was NOK 10 000 and funding for participation at European Space Camp, EU Contest for Young Scientists and Intel ISEF. Publications: Articles Bezem, M.T., Baumann, A., Martinez, A., Flydal, M. I., (2014) Partially inhibited tyrosine hydroxylase is very stable. In preparation. Bezem, M.T., Johannessen, F. G., Ying, M., Herfindal, L., Betbeder, D. Jorge-Finnigan, A. and Martinez, A., (2014) Maltodextrin nanoparticles deliver tyrosine hydroxylase to brain cells. In preparation. Wang, J., Kumeria, T., Bezem, M. T., Sailor, M. J., (2016) Self-reporting porous silicon microparticles for drug delivery applications. In preparation. Bezem, M. T. (2008), The use of micro fluidics to study nanotube-mediated signaling between cells. Young Scientists Journal 1 (6), pp. 22-26. Invited speaker presentations Bezem, M. T., Johannessen, F. G., Ying, M., Jorge-Finnigan, A., Betbeder, D. and Martinez, A., Nanoparticles for protein delivery to the brain, the Dementia network meeting. Bergen, Norway, June 3 2015. Bezem, M. T., Researchers of the future, the Norwegian research council’s annual business seminars, Oslo, Norway, April 24 2013. Bezem, M. T., Why choosing nanomedical research, “På Vei” carreer seminar series at the faculty of mathematics and natural sciences, University of Bergen, Norway, October 19 2010. Oral communications Bezem, M. T., Baumann, A., Meyer, R., Martinez, A. and Flydal, M. I., Construct design and cobalt are crucial determinants for high-quality preparations of human tyrosine hydroxylase, 6th Annual BioStruct conference, Jægtvolden, Norway, August 30 2015. Bezem, M. T., Ying, M., Jorge-Finnigan, A., Betbeder, D. and Martinez, A., Nanoparticles for protein delivery to the brain, 4th Annual Meeting of KG Jebsen’s Centre for Research on Neuropsychiatric Disorders, Bergen, Norway, June 3 2014. Bezem, M. T., Ying, M., Jorge-Finnigan, A., Betbeder, D. and Martinez, A., Intracellular delivery of tyrosine hydroxylase by nanoparticles, the nano-medical symposium, Bergen, Norway, April 8 2014. Bezem, M.T., Jorge-Finnigan, A., Betbeder, D. and Martinez, A., Delivery of Nanoparticle-bound Tyrosine Hydroxylase to Cells, the International Conference on Tetrahydrobiopterin, Phenylketonuria, Monoamine Neurotransmitters and Nitric Oxide Synthase, St. Moritz - Champfèr, Switzerland, March 18 – 21 2013. Bezem, M.T., Jorge-Finnigan, A., Betbeder, D. and Martinez, A., Stabilization of tyrosine hydroxylase in nanoparticles for enzyme replacement therapy, 49th Winter Meeting of the Norwegian Biochemical Society, Lillehammer, Norway, January 31 – February 3 2013. Bezem, M. T. and Martinez, A., Functionalization of nanoparticles with tyrosine hydroxylase, Therapeutic Nanoparticles Seminar, Bergen, Norway, November 2 2012. Bezem, M.T., Betbeder, D. Jorge-Finnigan, A. and Martinez, A., Delivery of Nanoparticle-bound Tyrosine Hydroxylase to Cells, SCANDEM 2012 the Annual Conference of the Nordic Microscopy Society, Bergen, Norway, June 12 – 15 2012. Posters Bezem, M.T., Jorge-Finnigan, A., Johannessen, Ying, M., F. G., Betbeder, D. and Martinez, A., Maltodextrin nanoparticles as carriers of tyrosine hydroxylase, European Nanomedicine Meeting, Grenoble, France, December 7 – 9 2015. Bezem, M. T., Jorge-Finnigan, A., Betbeder, D. and Martinez, A., Stabilization of Tyrosine Hydroxylase in Nanoparticles for Enzyme Replacement Therapy, 6th annual BioStruct conference, Jægtvollen, Norway, August 28 - 31 2015. Price for the best poster. Bezem, M.T., Betbeder, D. Jorge-Finnigan, A. and Martinez, A., Stabilization of tyrosine hydroxylase in nanoparticles for enzyme replacement therapy, 49th Winter Meeting of the Norwegian Biochemical Society, Lillehammer, Norway, January 31 – February 3 2013. Bezem, M. T., Jorge-Finnigan, A., Betbeder, D. and Martinez, A., Stabilization of Tyrosine Hydroxylase in Nanoparticles for Enzyme Replacement Therapy, 3rd annual BioStruct conference, Jægtvollen, Norway, August 31 2012. Price for the best poster. Bezem, M. T., Rios-Mondragón, I. and Gerdes, H.-H., The use of micro fluidics to study nanotube-mediated signaling between cells, the Nano day, Bergen, Norway, June 6 2008. Price for the best poster. Bezem, M. T., Population Models, Intel International Science and Engineering Fair, Atlanta, USA, May 12 2008. Bezem, M. T., A matematical investigation of the cod stock in the Barents sea using population models, EU Contest for Young Scientists, Valencia, Spain, September 17 2007. Bezem, M. T., What will happen to our fish? Norwegian Young Scientist Contest, Oslo, Norway, April 15 2007.