PUBLICATIONS 1. Borghi A., Giusti G., Boninsegni R., Fusi S., Fiorelli G., Calabresi E., Brandi M.L., Forti G. Studio ormonale di un paziente affetto da carcinoma corticosurrenale femminilizzante. J Endocrinol Invest. 4: 283, 1981. 2. Zonefrati R., Brandi M.L., Rotella C.M., Toccafondi R., Selli C. Parathyroid hormone bioassay using human kidney cortical cells in primary culture. Acta Endocrinol. 100: 398-405, 1982. 3. Toccafondi R.S., Brandi M.L., Rotella C.M., Zonefrati R. Studies of catecholamine effect on cyclic AMP in human cultured thyroid cells: their interaction with thyrotropin receptor. Acta Endocrinol. 102: 62-67, 1983. 4. Valente W.A., Vitti P., Kohn L.D., Brandi M.L., Rotella C.M., Toccafondi R., Tramontano D., Aloj S.M., Ambesi-Impiombato F.S. The relationship of growth and adenylate cyclase activity in cultured thyroid cells: separate bioeffects of thyrotropin. Endocrinology. 112: 71-79, 1983. 5. Gennari C., Toccafondi R., Rotella C.M., Francini G., Brandi M.L., Maioli E. Salmon calcitonin and cGMP production by human kidney: studies in vivo and in vitro. Calcif Tissue Int. 35: 273-278, 1983. 6. Brandi M.L., Rotella C.M., Tanini A., Toccafondi R.S. Evidence for alpha-adrenergic receptors acting through the guanylate cyclase system in human cultured thyroid cells. Acta Endocrinol. 104: 64-68, 1983. 7. Rotella C.M., Brandi M.L., Toccafondi R. Effect of prostaglandin E2 on adenylate cyclase system in human kidney cell cultures: interaction with parathormone and arginine-vasopressin. J Endocrinol Invest. 6: 369-374, 1983. 8. Toccafondi R.S., Brandi M.L., Melander A. Vasoactive intestinal peptide stimulation of human thyroid cell function. J Clin Endocrinol Metab. 58: 157-160, 1984. 9. Brandi M.L., Rotella C.M., Lopponi A., Kohn L.D., Aloj S.M., Toccafondi R. Forskolin perturbs cGMP as well as cAMP levels in human thyroid cells. Acta Endocrinol. 107: 225-229, 1984. 10. Rotella C.M., Brandi M.L., Toccafondi R.S. Human calcitonin increases both cyclic AMP and cyclic GMP accumulation in human kidney cells. Eur J Pharmacol. 107: 347-352, 1985. 11. Balboni G.C., Brandi M.L., Zonefrati R., Repice F. Effects of laser irradiation on collagen production by fibroblasts in vitro. Bull Assoc Anat. 69: 15-18, 1985. 12. Brandi M.L., Toccafondi R. Neuropeptidergic control of cyclic AMP accumulation in human thyroid cell. Peptides. 6: 641-644, 1985. 13. Brandi M.L., Zonefrati R., Rotella C.M., Toccafondi R. Catecholamine, vasoactive intestinal peptide and thyrotrophin-dependent cAMP levels display a different sensitivity to iodothyronines in both normal and pathological human thyroid cells in culture. Clin Endocrinol. 23: 503-509, 1985. 14. Brandi M.L., Rotella C.M., Zonefrati R., Toccafondi R., Aloj S.M. Loss of adrenergic regulation of cAMP production in the FRTL-5 cell line. Acta Endocrinol. 111: 54-61, 1986. 15. Brandi M.L., Fitzpatrick L.A., Fedak S., Aurbach G.D., Coon H.G. Differentiated bovine parathyroid cells cultured for more than 140 population doublings show both parathyroid hormone synthesis and growth regulation by calcium ion concentration. Prog Clin Biol Res. 226: 265-275, 1986. 16. Brandi M.L., Fitzpatrick L.A., Coon H.G., Aurbach G.D. Bovine parathyroid cells: cultures maintained for more than l40 population doublings. Proc Natl Acad Sci USA 83: 1709-1713, 1986. 17. Fitzpatrick L.A., Brandi M.L., Aurbach G.D. Prostaglandin F2 alpha and alpha-adrenergic agonists regulate parathyroid cell function via the inhibitory guanine nucleotide regulatory protein. Endocrinology. 118: 2115-2119, 1986. 18. Brandi M.L., Aurbach G.D., Fitzpatrick L.A., Quarto R., Spiegel A.M., Bliziotes M.M., Norton J.A., Doppman J.L., Marx S.J. Parathyroid mitogenic activity in plasma from patients with multiple endocrine neoplasia type I. N Engl J Med. 314: 1287-1293, 1986. 19. Brandi M.L., Rotella C.M., Kohn L.D., Toccafondi R. Unusual antagonistic actions of mixtures of vasoactive intestinal peptide, thyroid-stimulating antibodies, and cholera toxin on adenosine 3',5'-monophosphate accumulation in normal human thyroid cell cultures. J Clin Endocrinol Metab. 62: 1199-1205, 1986. 20. Balboni G.C., Brandi M.L., Zonefrati R., Repice F. Effects of He-Ne/I. R. laser irradiation on two lines of normal human fibroblasts in vitro. Arch Ital Anat Embriol. 91: 179-188, 1986. 21. Fitzpatrick L.A., Brandi M.L., Aurbach G.D. Control of PTH secretion is mediated through calcium channels and is blocked by pertussis toxin treatment of parathyroid cells. Biochem Biophys Res Commun. 138: 960-965, 1986. 22. De Leonardis V., Brandi M.L., De Scalzi M., Cinelli P. Effect of orthostatic stress on patients with borderline hypertension. IRCS Med. Sci. 14: 980, 1986. 23. Tanini A., Brandi M.L., Modigliani U., Rotella C.M., Toccafondi R. Transient lack of response to TSH of human cultured thyroid cells obtained from hyperfunctioning tissue. Acta Endocrinol. 113: 346-354, l986. 24. Brandi M.L., Aurbach G.D., Fattorossi A., Quarto R., Marx S.J., Fitzpatrick L.A. Antibodies cytotoxic to bovine parathyroid cells in autoimmune hypoparathyroidism. Proc Natl Acad Sci USA. 83: 8366-8369, 1986. 25. Fitzpatrick L.A., Brandi M.L., Aurbach G.D. Calcium-controlled secretion is effected through a guanine nucleotide regulatory protein in parathyroid cells. Endocrinology. 119: 2700-2703, 1986. 26. Sakaguchi K., Santora A., Zimering M., Curcio F., Aurbach G.D., Brandi M.L. Functional epithelial cell line cloned from rat parathyroid glands. Proc Natl Acad Sci USA. 84: 3269-3273, 1987. 27. Brandi M.L., Tanini A., Toccafondi R. Interaction of VIPergic and cholinergic receptors in human thyroid cell. Peptides 8: 893-897, 1987. 28. Brandi M.L., Rotella C.M., Tanini A., Toccafondi R., Aloj S.M. Cholinergic control of cyclic nucleotide metabolism in human thyroid cells. J Endocrinol Invest. 10: 451458, 1987. 29. Brandi M.L., Rotella C.M., Mavilia C., Franceschelli F., Tanini A., Toccafondi R. Insulin stimulates cell growth of a new strain of differentiated rat thyroid cells. Mol Cell Endocrinol. 54: 91-103, 1987. 30. Brandi M.L., Marx S.J., Aurbach G.D., Fitzpatrick L.A. Familial multiple endocrine neoplasia type 1: a new look at pathophysiology. Endocr Rev. 8: 391-405, 1987. 31. Bliziotes M., Yergey A.L., Nanes M.S., Muezner J., Begley M.G., Vieira N.E., Kher K.K., Brandi M.L., Marx S.J. Absent intestinal response to calciferols in hereditary resistance to 1,25dihydroxyvitamin D: documentation and effective therapy with high dose intravenous calcium infusions. J Clin Endocrinol Metab. 66: 294-300, 1988. 32. Fattorossi A., Aurbach G.D., Sakaguchi K., Cama A., Marx S.J., Streeten E.A., Fitzpatrick L.A., Brandi M.L. Anti-endothelial cell antibodies: detection and characterization in sera from patients with autoimmune hypoparathyroidism. Proc Nat Acad Sci USA. 85: 4015-4019, 1988. 33. Marx S.J., Sakaguchi K, Green J. 3rd, Aurbach G.D., Brandi M.L. Mitogenic activity on parathyroid cells in plasma from members of a large kindred with multiple endocrine neoplasia type I. J Clin Endocrinol Metab. 67: 149-153, 1988. 34. Aurbach G.D., Marx S.J., Sakaguchi K. Zimering M., Brandi M.L. Familial multiple endocrine neoplasia type I. Nippon Naibunpi Gakkai Zasshi. 64: 1209-1213, 1988. 35. Streeten E.A., Ornberg R., Curcio F., Sakaguchi K., Marx S.J., Aurbach G.D., Brandi M.L. Cloned endothelial cells from fetal bovine bone. Proc Natl Acad Sci USA. 86: 916-920, 1989. 36. Coon H.G., Curcio F., Sakaguchi K., Brandi M.L., Swerdlow R.D. Cell cultures of neuroblasts from rat olfactory epithelium that show odorant responses. Proc Natl Acad Sci USA. 86: 17031707, 1989. 37. Bale S.J., Bale A.E., Stewart K., Dachowski L., McBride O.W., Glaser T., Green J.E. 3rd, Mulvihill J.J, Brandi M.L., Sakaguchi K., Aurbach G.D., et al. Linkage analysis of multiple endocrine neoplasia type I with INT2 and other markers on chromosome 11. Genomics. 4: 320322, 1989. 38. Ikeda K., Weir E.C, Sakaguchi K., Burtis W.J., Zimering M., Mangin M., Dreyer B.E., Brandi M.L., Aurbach G.D., Broadus A. Clonal rat parathyroid cell line expresses a parathyroid hormone-related peptide but not parathyroid hormone itself. Biochem Biophys Res Commun. 162: 108-115, 1989. 39. Friedman E., Sakaguchi K., Bale A.E., Falchetti A., Streeten E., Zimering M.B., Weinstein L.S., McBride W.O., Nakamura Y., Brandi M.L., Norton J.A., Aurbach G.D., Spiegel A.M., Marx S.J. Clonality of parathyroid tumors in familial multiple endocrine neoplasia type I. N Engl J Med. 321: 213-218, 1989. 40. Yanagishita M., Brandi M.L., Sakaguchi K. Characterization of proteoglycans synthesized by a rat parathyroid cell line. J Biol Chem. 26: 15714-15720, 1989. 41. Tarquini B., Benvenuti M., Brandi M.L., Cecchettin M., Ianes A. Short-term effects of heparin on urine hydroxyproline in the elderly. Curr. Ther. Res. 46: 755, 1989. 42. Zimering M.B., Brandi M.L., deGrange D.A., Marx S.J., Streeten E., Katsumata N., Murphy P.R., Sato Y., Friesen H.G., Aurbach G.D. Circulating fibroblast growth factor-like substance in familial multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 70: 149-154, 1990. 43. Brandi M.L. A novel endothelial cell growth factor circulates in familial multiple endocrine neoplasia type 1. Int J Rad Appl Instrum B. 17: 639-643, 1990. 44. Orlando C., Brandi M.L., Peri A., Giannini S., Fantoni G., Calabresi E., Serio M., Maggi M. Neurohypophyseal hormone regulation of endothelin secretion from rabbit endometrial cells in primary culture. Endocrinology. 126: 1780-1782, 1990. 45. Sakaguchi K., Ikeda K., Curcio F., Aurbach G., Brandi M.L. Subclones of a rat parathyroid cell line (PT-r): regulation of growth and production of parathyroid hormone-related peptide (PTHRP). J Bone Miner Res. 8: 863-869, 1990. 46. Streeten E.A., Brandi M.L. Biology of bone endothelial cells. Bone Miner. 10: 85-94, 1990. 47. Brandi M.L., Ornberg R.L., Sakaguchi K., Curcio F., Fattorossi A., Lelkes P.I., Matsui T., Zimering M., Aurbach G.D. Establishment and characterization of a clonal line of parathyroid endothelial cells. FASEB J. 4: 3152-3158, 1990. 48. Maggi M., Fantoni G., Peri A., Giannini S., Brandi M.L., Orlando C., Serio M. Steroid modulation of oxytocin/vasopressin receptors in the uterus. J Steroid Biochem Mol Biol. 40: 481-491, 1991. 49. Brandi M.L. Multiple endocrine neoplasia type I: general features and new insights into etiology. J Endocrinol Invest. 14: 61-72, 1991. 50. Maggi M., Vannelli G.B., Peri A., Brandi M.L., Fantoni G., Giannini S., Torrisi C., Guardabasso V., Barni T., Toscano V., Massi G., Serio M. Immunolocalization, binding, and biological activity of endothelin in rabbit uterus: effect of ovarian steroids. Am J Physiol. 260: E292-305, 1991. 51. Bale A.E., Norton J.A., Wong E.L., Fryburg J.S., Maton P.N., Oldfield E.H., Streeten E., Aurbach G.D., Brandi M.L., Friedman E., Spiegel A.M., Taggart R.T., Marx S.J. Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1. Cancer Res. 51: 1154-1157, 1991. 52. Fujii Y., Moreira J.E., Orlando C., Maggi M., Aurbach G.D., Brandi M.L., Sakaguchi K. Endothelin as an autocrine factor in the regulation of parathyroid cells. Proc Natl Acad Sci USA 88: 4235-4239, 1991. 53. Benvenuti S., Tanini A., Frediani U., Bianchi S., Masi L., Casano R., Bufalino L., Serio M., Brandi M.L. Effects of ipriflavone and its metabolites on a clonal osteoblastic cell line. J Bone Miner Res. 6: 987-996, 1991. 54. Amorosi A., Tanini A., Cicchi P., Bandini S., Brandi M.L. parathyroid tumors. J. Min. Electrol Metab. 5: 1, 1991. 55. De Feo M.L., Bartolini O., Orlando C., Maggi M., Serio M., Pines M., Hurwitz S., Fujii Y., Sakaguchi K., Aurbach G.D., Brandi M.L. Natriuretic peptide receptors regulate endothelin synthesis and release from parathyroid cells. Proc. Natl. Acad. Sci. USA 88: 6496-6500, 1991. Clonal analysis of human 56. Scherubl H., Brandi M.L., Hescheler J. Extracellular Ca2+ sensing in C-cells and parathyroid cells. Henry Ford Hosp Med J. 40: 303-306, 1992. 57. Brandi M.L. Genetic models for parathyroid tumorigenesis. J Endocrinol Invest. 15: 113-119, 1992. 58. Gattei V., Bernabei P.A., Pinto A., Bezzini R., Ringressi A., Formigli L., Tanini A., Attadia V., Brandi M.L. Phorbol ester induced osteoclast-like differentiation of a novel human leukemic cell line (FLG 29.1). J Cell Biol. 116: 437-447, 1992. 59. Brandi M.L. Parathyroid tumor biology in familial multiple endocrine neoplasia type 1: a model for cancer development. Henry Ford Hosp Med J. 40: 181-185, 1992. 60. Robinson M.F., Furst E.J., Nunziata V., Brandi M.L., Ferrer J.P., Martins Bugalho M.J., di Giovanni G., Smith R.J., Donovan D.T., Alford B.R., Hejtmancik J.F., Colantuoni V., Quadro L., Limbert E., Halperin I., Vilardell E., Gagel R.F. Characterization of the clinical features of five families with hereditary primary cutaneous lichen amyloidosis and multiple endocrine neoplasia type 2. Henry Ford Hosp Med J. 40: 249-252, 1992. 61. Brandi M.L. Bone endothelial cells: a tool for analyzing cell to cell interactions in the skeleton tissue. EXS. 61: 250-254, 1992. 62. Failli P., Ruocco C., Tanini A., Brandi M.L., Benvenuti S., Franceschelli F., Giotti A. Endothelin-1 increases intracellular calcium content in bovine parathyroid endothelial cells. Pharmacol Res. 25: 23-24, 1992. 63. Brandi M.L. Multiple endocrine neoplasms. Recenti Prog Med. 83: 155-159, 1992. 64. Bigazzi M., Brandi M.L., Bani G., Sacchi T.B. Relaxin influences the growth of MCF-7 breast cancer cells. Mitogenic and antimitogenic action depends on peptide concentration. Cancer 70: 639-643, 1992. 65. Streeten E.A., Weinstein L.S., Norton J.A., Mulvihill J.J., White B.J., Friedman E., Jaffe G., Brandi M.L., Stewart K., Zimering M.B., Spiegel A.M., Aurbach G.D., Marx S.J. Studies in a kindred with parathyroid carcinoma. J Clin Endocrinol Metab. 75: 362-366, 1992. 66. Scappaticci S., Brandi M.L., Capra E., Cortinovis M., Maraschio P., Fraccaro M. Cytogenetics of multiple endocrine neoplasia syndrome. II. Chromosome abnormalities in an insulinoma and glucagonoma from two subjects with MEN 1. Cancer Genet Cytogenet. 63: 17-21, 1992. 67. Bonucci E., Silvestrini G., Ballanti P., Masi L., Franchi A., Bufalino L., Brandi M.L. Cytological and ultrastructural investigation on osteoblastic and preosteoclastic cells grown in vitro in the presence of ipriflavone: preliminary results. Bone Miner. 19: S15-25, 1992. 68. Brandi M.L. Flavonoids: biochemical effects and therapeutic applications. Bone Miner. 19: S3-14, 1992. 69. Masi L., Franchi A., Santucci M., Danielli D., Arganini L., Giannone V., Formigli L., Benvenuti S., Tanini A., Beghè F., Mian M., Brandi M.L. Adhesion, growth and matrix production by osteoblasts on collagen substrata. Calcif Tissue Int. 51: 202-212, 1992. 70. Giori P., Franceschelli F., Frediani U., Masi L., Giannone V., Gallini C., Modigliani U., Tanini A., Brandi M.L. Biological effects of heparin on various bone cell types. Diab. Nutr. Metab. 5: 225-230, 1992. 71. Bani D., Brandi M.L., Axiotis C.A., Bani-Sacchi T. Detection of P-glycoprotein on endothelial and endocrine cells of the human pancreatic islets by C 494 monoclonal antibody. Histochemistry 98: 207209, 1992. 72. Formigli L., Zecchi S., Benvenuti S., Brandi M.L. Cell-to-cell interactions in bone tissue. Ann N Y Acad Sci. 673: 120-125, 1992. 73. Calmettes C., Ponder B.A.J., Fischer J.A., Raue F., Body J.J., Brandi M.L., Garcia-Ameijeiras, Hansen H.S., Koutras D.A., Lenoir G.M., Limbert E., Moller P., Telenius-Berg M., Vasen H.F.A. Early diagnosis of the multiple endocrine neoplasia type 2 syndrome: consensus statement. Eur. J. Clin. Invest. 22: 755, 1992. 74. Falchetti A., Bale A.E., Amorosi A., Bordi C., Cicchi P., Bandini S., Marx S.J., Brandi M.L. Progression of uremic hyperparathyroidism involves allelic loss on chromosome 11. J Clin Endocrinol Metab. 76: 139-144, 1993. 75. Brandi M.L. Ipriflavone influences the osteoblastic phenotype in vitro. Osteoporos Int. 1: S226-229, 1993. 76. Rotella C.M., Galli G., Casini S., Bianchi S., Mannucci E., Cresci B., Schuppan D., Conti A., Brandi M.L. Release of extracellular matrix components by bovine bone endothelial cells in continuous culture. Biochem Biophys Res Commun. 190: 502-508, 1993. 77. Brandi M.L., Gennai C. Ipriflavone: new insights into its mechanisms of action on bone remodeling. Calcif Tissue Int. 52: 151-152, 1993. 78. Brandi M.L. Cellular models for the analysis of paracrine communications in parathyroid tissue. J Endocrinol Invest. 16: 303-314, 1993. 79. Fincato G., Bartucci F., Rigoldi M., Abbiati G., Colombo M., Bartolini O., Brandi M.L., De Leonardis V. Urinary excretion of pyridinoline and deoxypyridinoline: circadian rhythm in healthy premenopausal women. J Interdiscipl Cycle Res. 24: 72, 1993. 80. Papi L., Baldassarri G., Montali E., Bigozzi U., Ammannati F., Brandi M.L. Cytogenetics studies in sporadic and multiple endocrine neoplasia type I-associated pituitary adenomas. Genes Chromosomes Cancer. 7: 63-65, 1993. 81. Zimering M.B., Katsumata N., Sato Y., Brandi M.L., Aurbach G.D., Marx S.J., Friesen H.G. Increased basic fibroblast growth factor in plasma from multiple endocrine neoplasia type 1: relation to pituitary tumor. J Clin Endocrinol Metab. 76: 1182-1187, 1993. 82. Tanini A., Failli P., Maggi M., Franceschelli F., Frediani U., Becherini L., Giotti A., Ruocco C., Brandi M.L. Effects of endothelin-1 on bovine parathyroid cells. Biochem Biophys Res Commun. 193: 59-66, 1993. 83. Yang Y.W., Pioli P., Fiorelli G., Brandi M.L., Rechler M.M. Cyclic adenosine monophosphate stimulates insulin-like growth factor binding protein-4 and its messenger ribonucleic acid in a clonal endothelial cell line. Endocrinology. 133: 343351, 1993. 84. D'Adda T., Amorosi A., Bussolati G., Brandi M.L., Bordi C. Proliferation of endothelial component of parathyroid gland in multiple endocrine neoplasia type 1. Potential relationship with a mitogenic factor. Am J Pathol. 143: 612-617, 1993. 85. Maraschio P., Pezzolo A., Brandi M.L., Cortinovis M., Dainotti E., Scappaticci S., Fraccaro M. Cytogenetics of multiple endocrine neoplasia syndromes. III. Analysis of an insulinoma from a subject with MEN 1 by chromosome painting. Cancer Genet Cytogenet. 70: 68-70, 1993. 86. De Feo M.L., Franceschelli F., Frediani U., Tosti-Guerra C., Crescioli C., Tanini A., Bartolini O., Becorpi A., Serio M., Brandi M.L. Natriuretic hormone receptors and actions on bone endothelial cells. Endocrinology. 133: 1759-1766, 1993. 87. Brandi M.L., Crescioli C., Tanini A., Frediani U., Agnusdei D., Gennari C. Bone endothelial cells as estrogen targets. Calcif Tissue Int. 53: 312-317, 1993. 88. Brandi M.L. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med. 95: 69S-74S, 1993. 89. Brandi M.L., Weber G., Svensson A., Falchetti A., Tonelli F., Castello R., Furlani L., Scappaticci S., Fraccaro M., Larsson C. Homozygotes for the autosomal dominant neoplasia syndrome (MEN 1). Am J Hum Genet. 53: 1167-1172, 1993. 90. Zecchi-Orlandini S., Formigli L., Brandi M.L. Relationship between endothelium and bone cells. Ital J Mineral Electrolyte Metab. 7: 147, 1993. 91. Bordi C., Falchetti A., Buffa R., Azzoni C., D'Adda T., Caruana P., Rindi G., Brandi M.L. Production of basic fibroblast growth factor by gastric carcinoid tumors and their putative cells of origin. Hum Pathol. 25: 175-180, 1994. 92. Calabresi E., Lasagni L., Franceschelli F., Bartolini L., Serio M., Brandi M.L. Use of an internal standard to measure pyridinoline and deoxypyridinoline in urine. Clin Chem. 40: 336337, 1994. 93. Pollak M.R., Chou Y.H., Marx S.J., Steinmann B., Cole D.E., Brandi M.L., Papapoulos S.E., Menko F.H., Hendy G.N., Brown E.M., Seidman C.E., Seidman J.G. Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism: Effects of mutant gene dosage on phenotype. J Clin Invest. 93: 1108-1112, 1994. 94. Fiorelli G., Orlando C., Benvenuti S., Franceschelli F., Bianchi S., Pioli P., Tanini A., Serio M., Bartucci F., Brandi M.L. Characterization, regulation, and function of specific cell membrane receptor for insulin-like growth factor I on bone endothelial cells. J Bone Miner Res. 9: 329-337, 1994. 95. Sacchi T.B., Bani D., Brandi M.L., Falchetti A., Bigazzi M. Relaxin influences growth, differentiation and cell-cell adhesion of human breast-cancer cells in culture. Int J Cancer. 57: 129-134, 1994. 96. Tonelli F., Valanzano R., Brandi M.L. Pharmacologic treatment of desmoid tumors in familial adenomatous polyposis: results of an in vitro study. Surgery. 115: 473-479, 1994. 97. Benvenuti S., Petilli M., Frediani U., Tanini A., Fiorelli G., Bianchi S., Bernabei P.A., Albanese C., Brandi M.L. Binding and bioeffects of ipriflavone on a human preosteoclastic cell line. Biochem Biophys Res Commun. 201: 1084-1089, 1994. 98. Quadro L., Panariello L., Salvatore D., Carlomagno F., Del Prete M., Nunziata V., Colantuoni V., Di Giovanni G., Brandi M.L., Mannelli M., Gheri R., Verga U., Libroia A., Berger N., Fusco A., Grieco M., Santoro M. Frequent RET protoncogene mutations in Multiple Endocrine Neoplasia Type 2A. J Clin Endocrinol Metab. 79: 590-594, 1994. 99. Calabresi E., Lasagni L., Franceschelli F., de Leonardis V., Becorpi A., Serio M., Brandi M.L. Comparison of immuno-and HPLC-assay for the measurement of urinary collagen cross-links. J Endocrinol Invest. 17: 625629, 1994. 100. Galli G., Casini A., Cresci B., Mannucci E., Manuelli C., Schuppan D., Surrenti C., Conti A., Brandi M.L., Rotella C.M. Effects of insulin and glucose on the growth and the release of extracellular matrix components by bovine bone endothelial cells. Endocr. J. 2: 559, 1994. 101. Brandi M.L., Bianchi M.L., Eisman J.A., Glorieux F., Adami S., Fiore C. E., Nuti R., Ortolani S. Genetics of Osteoporosis. Calcif Tissue Int. 55: 161-163, 1994. 102. Fiorelli G., Ballock R.T., Wakefield L.M., Sporn M.B., Gori F., Masi L., Frediani U., Tanini A., Bernabei P.A., Brandi M.L. Role for autocrine TGF-ß1 in regulating differentiation of a human leukemic cell line toward osteoclast-like cells. J Cell Physiol. 160: 482-490, 1994. 103. Ida R., Lee A., Huang J., Brandi M.L., Yamaguchi D.T. Prostaglandin-stimulated second messenger signaling in bone-derived endothelial cells is dependent on confluency in culture. J Cell Physiol. 160: 585-595, 1994. 104. Bianchi S., Fabiani S., Muratori M., Arnold A., Sakaguchi K., Miki T., Brandi M.L. Calcium modulates the cyclin D1 expression in a rat parathyroid cell line. Biochem Biophys Res Commun. 204: 691-700, 1994. 105. Zimering M.B., Riley D.J., Thakker-Varia S., Walker A.M., Lakshminaryan, Shah R., Brandi M.L., Ezzat S., Katsumata, Friesen H.G., Marx S.J., Eng J. Circulating fibroblast growth factorlike autoantibodies in two patients with multiple endocrine neoplasia type 1 and prolactinoma. J Clin Endocrinol Metab. 79: 1546-1552, 1994. 106. Amorosi A., Nesi G., Spini S., Tonelli F., Falchetti A., Brandi M.L. Histologic features of parathyroid hyperplasia in multiple endocrine neoplasia type 1 (MEN 1). Diagnostic and surgical implications. Acta Chir Austriaca, Suppl. 112: 13, 1994. 107. Tonelli F., Spini S., Gabbrielli, Falchetti A., Tommasi M.S., Castello R., Furlan L., Brandi M.L. The surgical treatment of hyperparathyroidism in multiple endocrine neoplasia type 1 (MEN 1) syndrome. Acta Chir Austriaca 112: 26, 1994. 108. Franchi A., Masi L., Simoni G., Sozzi C., Arganini L., Baroni G., Sporn M.B., Brandi M.L. Expression of extracellular matrix components and transforming growth factor ß1 in cultured human fetal long bones. Cell Vision 1: 296, 1994. 109. Bordi C., Falchetti A., Azzoni C., D’Adda T., Morelli A., Peracchia A., Brandi M.L. Lack of allelic loss at the multiple endocrine neoplasia type 1 (MEN-1) gene locus in a pancreatic ductal (non-endocrine) adenocarcinoma of a patient with the MEN-1 syndrome. Virchows Arch. 426: 203-208, 1995. 110. Formigli L., Orlandini S.Z., Benvenuti S., Masi L., Pinto A., Gattei V., Bernabei P.A., Robey P.G., Collin-Osdoby P., Brandi M.L. In vitro structural and functional relationship between preosteoclastic and bone endothelial cells: a juxtacrine model for migration and adhesion of osteoclast precursors. J Cell Physiol. 162: 199-212, 1995. 111. Petilli M., Fiorelli G., Benvenuti S., Frediani U., Gori F., Brandi M.L. Interactions between ipriflavone and the estrogen receptor. Calcif Tissue Int. 56: 160-165, 1995. 112. Axiotis C.A., Bani D., Bianchi S., Pioli P., Tanini A., Brandi M.L. P-glycoprotein is expressed in parathyroid epithelium and is regulated by calcium. Calcif Tissue Int. 56: 170-174, 1995. 113. Masi L., Brandi M.L., Robey P.G., Crescioli C., Calvo J.C., Bernabei P., Kerr J.M., Yanagishita M. Biosynthesis of bone sialoprotein by a human osteoclast-like cell line (FLG 29.1). J Bone Miner Res. 10: 187-196, 1995. 114. Morelli A., Falchetti A., Weinstein L., Fabiani S., Tomassetti P., Enzi G., Carraro R., Bordi C., Tonelli F., Brandi M.L. RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis and multiple endocrine neoplasia type 1-associated lipomas. Biochem Biophys Res Commun. 207: 363-368, 1995. 115. Brandi M.L., Hukkanen M., Umeda T., Moradi-Bihendi N., Bianchi S., Gross S.S., Polak J.M., MacIntyre I. Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Proc Natl Acad Sci USA. 92: 2954-2958, 1995. 116. Fiorelli G., Gori F., Petilli M., Tanini A., Benvenuti S., Serio M., Bernabei P., Brandi M.L. Functional estrogen receptors in a human preosteoclastic cell line. Proc Natl Acad Sci USA. 92: 2672-2676, 1995. 117. Morelli A., Falchetti A., Castello R., Furlani L., Tomassetti P., Tonelli F., Frilling A., Serio M., Brandi M.L. Genetic screening to identify the gene carrier in Italian and German kindreds affected by multiple endocrine neoplasia type 1 (MEN 1) syndrome. J Endocrinol Invest. 18: 329-335, 1995. 118. Formigli L., Orlandini S.Z., Tonelli P., Giannelli M., Martini M., Brandi M.L., Bergamini M., Orlandini G.E. Osteolytic processes in human radicular cysts: morphological and biochemical results. J Oral Pathol. Med. 24: 216-220, 1995. 119. Fujii Y., Tomic M., Stojilkovic S.S., Iida T., Brandi M.L., Ogino Y., Sakaguchi K. Effects of endothelin-1 on Ca2+ signaling and secretion in parathyroid cells. J Bone Miner Res. 10: 716725, 1995. 120. Chou Y.H., Pollak M.R., Brandi M.L., Toss G., Arnquist H., Atkinson A.B., Papapoulos S.E., Marx S.J., Brown E.M., Seidman J.G., Seidman C.E. Mutations in the human calcium-sensing receptor gene that cause familial hypocalciuric hypercalcemia. 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Novel mutations and inactivation of both alleles of the APC gene in desmoid tumors. Hum Mol Genet. 4: 1979-1981, 1995. 125. Masi L., Franchi A., Valenti C., Santucci M., Comin C.E., Danielli D., Beghè F., Brandi M.L. Human articular chondrocytes cultured with collagen type I express a differentiatedproliferating phenotype. Cell Vision 2: 111, 1995 (attualmente Applied Immunohistochemistry and Molecular Morphology). 126. Gheri R.G., Brandi M.L. The Italian register of MEN syndromes: Results of the work of the Italian Group of Study. J. Endocrinol. Invest. 18 : 116, 1995. 127. Manuelli C., Galli G., Biondi P., Perri P., Melani P., Zonefrati R., Casini A., Vannelli G., Gloria L., Surrenti C., Shuppan D., Conti A., Brandi M.L., Rotella C.M. Characterization and cloning of bovine retinal endothelial cells (BREC) in long-term culture. Diab. Nutr. Metab. 8: 281, 1995. 128. Brandi M.L., Masi L. Experimental models of bone tissue: their application in study of osteoporosis. 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Frediani U., Benvenuti S., Masi L., Tanini A., Brandi M.L. Histamine receptors and bioeffects on clonal parathyroid endothelial cells. J Endocrinol Invest. 19: 298-303, 1996. 135. Zecchi-Orlandini S., Formigli L., Giannelli M., Martini M., Tonelli P., Brandi M.L. Radicular cysts are involved in the recruitment of osteoclast precursors. J Oral Pathol Med. 25: 325-330, 1996. 136. Brandi M.L., Falchetti A., Tonelli F., Bordi C. Are allelic losses at 11q13 universal in MEN1 tumors? J Clin Endocrinol Metab. 81: 3162-3163, 1996. 137. Fiorelli G., Gori F., Frediani U., Franceschelli F., Tanini A., Tosti-Guerra C., Benvenuti S., Gennari L., Becherini L., Brandi M.L. Membrane binding sites and non-genomic effects of estrogen in cultured human preosteoclastic cells. J Steroid Biochem Mol. Biol. 59: 233-240, 1996. 138. Morelli A., Falchetti A., Tonelli F., Bearzi I., Ranaldi R., Tomassetti P., Brandi M.L. Clonal analysis by chromosome 11 microsatellite-PCR of microdissected parathyroid tumors from MEN 1 patients. Biochem Biophys Res Commun. 227: 736-742, 1996. 139. Bjarnason N.H., Brandi M.L., Cosman F., Greenspan S.L., Harper K.D., Heegaard A.M., Jolly E.E., Nelson D.A., Semler J., Stern P.H., Caballero M.A., Dawson A., Dere W.H., Draper M.W., Glusman J., Termine J.D., Wright T.J. Health issues in the peri- and postmenopausal woman: a multinational perspective of women and their doctors. J Women’s Health 5: 373, 1996. 140. Giovannini M., Strippoli P., Serra M., Sironi M., Fincato G., Colotta F., Bonafé M., Biunno I., Mantovani A., Zecchi-Orlandini S., Brandi M.L., Pastano R., Bagnara G.P. Production of interleukin-6 by human osteoclast-like cells from giant cell tumor of bone. Int J Oncol 8: 296, 1996. 141. Benvenuti S., Masi L., Falchetti A., Mancini L., Formigli L., Zecchi S., Amorosi A., Tonelli F., Brandi M.L. HPE cells: a clonal endothelial cell line established from human parathyroid tissue (human parathyroid cell line). Endothelium 5: 37-49, 1997. 142. Brandi M.L. Molecular mechanisms of parathyroid hyperplasia and neoplasia. Horm Res. 47: 194-198, 1997. 143. Brandi M.L. Natural and synthetic isoflavones in the prevention and treatment of chronic diseases. Calcif Tissue Int. 61: S5-S8, 1997. 144. Mancini L., Becherini L., Benvenuti S., Brandi M.L. Bioeffects of a nitric oxide donor in a human preosteoclastic cell line. Int J Clin Pharmacol. Res. 17: 93-96, 1997. 145. Khalkhali-Ellis Z., Collin-Osdoby P., Li L., Brandi M.L., Osdoby P. A human homolog of the 150 kD avian osteoclast membrane antigen related to superoxide dismutase and essential for bone resorption is induced by developmental agents and opposed by estrogen in FLG 29.1 cells. Calcif. Tissue Int. 60: 187-193, 1997. 146. Formigli L., Fiorelli G., Benvenuti S., Tani A., Orlandini G.E., Brandi M.L., Zecchi-Orlandini S. Insulin-like growth factor-I stimulates in vitro migration of preosteoclasts across bone endothelial cells. Cell Tissue Res. 288: 101-110, 1997. 147. Picariello L., Fiorelli G., Benvenuti S., Brandi M.L., Galli G., Malentacchi C., Montali E., Bigozzi U., Ficari F., Tonelli F. In vitro bioeffects of the antiestrogen LY117018 on desmoid tumor and colon cancer cells. Anticancer Res. 17: 2099-2104, 1997. 148. Bruni V., Bigozzi L., Dei M., Brandi M.L. Bone mineral metabolism in diet-induced amenorrea. Ann N Y Acad Sci. 816: 250-262, 1997. 149. Falchetti A., Morelli A., Amorosi A., Tonelli F., Fabiani S., Martineti V., Castello R., Furlani L., Brandi M.L. Allelic Loss in parathyroid tumors from individuals homozygous for multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 82: 2278-2282, 1997. 150. Locchi F., Tommasi M., Brandi M.L., Tonelli F., Meldolesi U. A controversial problem: is there a relationship between parathyroid hormone level and parathyroid size in primary hyperparathyroidism? Int J Biol Markers 12: 106-111, 1997. 151. Bordi C., Falchetti A., Azzoni C., D’Adda T., Canavese G., Guariglia A., Santini D., Tomassetti P., Brandi M.L. Aggressive forms of gastric neuroendocrine tumors in multiple endocrine neoplasia type I. Am J Surg Pathol. 21: 1075-1082, 1997. 152. Fiorelli G., Martineti V., Gori F., Benvenuti S., Frediani U., Formigli L., Zecchi S., Brandi M.L. Heterogeneity of binding sites and bioeffects of raloxifene on the human leukemic cell line FLG 29.1. Biochem Biophys Res Commun. 240: 573-579, 1997. 153. Gennari L., Becherini L., Masi L., Gonnelli S., Cepollaro C., Martini S., Mansani R., Brandi M.L. Vitamin D receptor genotypes and intestinal calcium absorption in postmenopausal women. Calcif Tissue Int. 6: 460-463, 1997. 154. Becherini L., Frediani U., Gennari F., Gori F., Fiorelli A., Tanini A., Brandi M.L. Role of estrogenic and antiestrogenic molecules in osteoclastogenesis. It J Min Electrol Metab.11: 1-8, 1997. 155. Mancini L., Moradi-Bidhendi N., Brandi M.L., MacIntyre I. Nitric oxide superoxide and peroxynitrite modulate osteoclast activity. Biochem Biophys Res Commun. 243: 785-790, 1998. 156. Gennari L., Becherini L., Masi L., Mansani R., Gonnelli S., Cepollaro C., Martini S., Montagnani A., Lentini G., Becorpi A.M., Brandi M.L. Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women: evidence of multiple gene contribution on bone mineral density. J Clin Endocrinol Metab. 83: 939-944, 1998. 157. Masi L., Becherini L., Gennari L., Colli E., Mansani R., Falchetti A., Cepollaro C., Gonnelli S., Tanini A., Brandi M.L. Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women. Biochem Biophys Res Commun. 245: 622-626, 1998. 158. Bordi C., Brandi M.L. Ductal adenocarcinoma of the pancreas in MEN-1-patients. Virchows Arch. 432: 385-386, 1998. 159. Masi L., Becherini L., Colli E., Gennari L., Mansani R., Falchetti A., Becorpi A.M., Cepollaro C., Gonnelli S., Tanini A., Brandi M.L. Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women. Biochem Biophys Res Commun 248: 190-195, 1998. 160. Fiorelli G., Frediani U., Martineti V., Franchi A., Gori F., Franceschelli F., Tanini A., Serio M., Brandi M.L. Aromatase expression and activity in the human leukaemic cell line FLG 29.1. J Steroid Biochem Mol Biol. 66: 105-112, 1998. 161. Martini M., Formigli L., Tonelli P., Giannelli M., Amunni F., Naldi D., Brandi M.L., Zecchi Orlandini S., Orlandini G.E. Effects of ipriflavone on perialveolar bone formation. Calcif Tissue Int. 63: 312-319, 1998. 162. Franchi A., Arganini L., Baroni G., Calzolari A., Capanna R., Campanacci D., Caldora P., Masi L., Brandi M.L., Zampi G. Expression of transforming growth factor isoforms in osteosarcoma variants: association of TGF1 with high-grade osteosarcomas. J Pathol. 185: 284-289, 1998. 163. Hofmann M., Schilling T., Heilmann P., Haisken O., Wuster C., Brandi M.L., Ziegler R., Nawroth P.P. Multiple endocrine neoplasia associated with multiple lipomas. Med Klin 93: 546-549, 1998. 164. Carlinfante G., Lampugnani R., Azzoni C., Aprile M.R., Brandi M.L., Bordi C. Expression of the - and - subunits of human chorionic gonadotropin by subsets of parathyroid cells in states of hyperparathyroidism. J Pathol. 185: 389-393, 1998. 165. Jeschke M., Brandi M.L., Susa M. Expression of Src family kinases and their putative substrates in the human preosteoclastic cell line FLG 29.1. J Bone Miner Res. 13: 1880-1889, 1998. 166. Picariello L., Brandi M.L., Formigli L., Orlandini S.Z., Dolara P., Caderni G., Raimondi L., Tonelli F. Apoptosis induced by sulindac sulfide in epithelial and mesenchymal cells from human abdominal neoplasms. Eur J Pharmacol. 360: 105-112, 1998. 167. Falchetti.A., Brandi.M.L. Genetic testing for multiple endocrine neoplasias. Related Cancer 5: 37-44, 1998. 168. Mutation analysis group: teh B.T., Kytölä S., Farnebo F., Bergman L., Wong F.K., Hayward N., Larsson C. Clinical diagnosis group: Skogseid B., Beckers A., Phelan C., Edwards M., Epstein M., Alford F., Hurley D., Grimmond S., Silins G., Walters M., Stewart C., Cardinal J., Khodaei S., Parente F., Tranebjærg L., Jorde R., Menon J., Khir A., Tan T.T., Chan S.P., Zaini A., Khalid B.A.K., Sandelin K., Thompson N., Brandi M.L., Warth M., Stock J., Leisti J., Cameron D., Shepherd J.J., Öberg K., Nordenskjöld M., Salmela P. Mutation analysis of the MEN 1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism. J. Clin. Endocrinol. Metab. 83: 2621-2626, 1998. 169. Bordi C., D'Adda T., Azzoni C., Canavese G., Brandi M.L. Gastrointestinal endocrine tumors: recent developments. Endocr. Pathol 9: 99-115, 1998. 170. Zecchi-Orlandini S., Formigli L., Tani A., Benvenuti S., Fiorelli G., Papucci L., Capaccioli S., Orlandini G.E., Brandi M.L. 17 -estradiol induces apoptosis in the preosteoclastic FLG 29.1 cell line. Biochem Biophys Res Commun. 255: 680-685, 1999. 171. Fiorelli G., Picariello L., Martineti V., Tonelli F., Brandi M.L. Functional estrogen receptor in colon cancer cells. Biochem Biophys Res Commun. 261: 521-527, 1999. 172. Gennari L., Becherini L., Mansani R., Masi L., Falchetti A., Morelli A., Colli E., Gonnelli S., Cepollaro C., Brandi M.L. FOK I Polymorphism at translation initiation site of the vitamin D receptor gene predicts bone mineral density and vertebral fractures in postmenopausal Italian women. J Bone Miner Res. 14: 1379-1386, 1999. 173. Fiorelli G., Brandi M.L. Skeletal effects of estrogens. J Endocrinol Invest. 22: 589-593, 1999. 174. Falchetti A., Becherini L., Martineti V., Morelli A., Benvenuti S., Picariello L., Gennari L., Lampugnani R., Bordi, Brandi M.L. Telomerase repeat amplification protocol (TRAP): A new molecular marker for parathyroid carcinoma. Biochem Biophys Res Commun. 265: 252-255, 1999. 175. Brandi M.L., Becherini L., Gennari L., Racchi M., Bianchetti A., Nacmias B., Sorbi S., Mecocci P., Senin U., Govoni S. Association of the estrogen receptor gene polymorphisms with sporadic Alzheimer's disease. Biochem Biophys Res Commun. 265: 335-338, 1999. Endocrine- 176. 177. Sakai K., Mohtai M., Shida J., Harimaya K., Benvenuti S., Brandi M.L., Kukita T., Iwamoto Y. Fluid shear stress increases interleukin-11 expression in human osteoblast-like cells: its role in osteocalst induction. J Bone Miner Res. 14: 2089-2097, 1999. Brandi M.L. Phytoestrogens and menopause. Environ Tox Pharm 7: 213-216, 1999. 178. Fiorelli G., Picariello L., Martineti V., Tonelli F., Brandi M.L. Estrogen synthesis in human colon cancer epithelial cells. J Steroid Biochem Mol Biol. 71: 223-230, 1999. 179. Morelli A., Falchetti A., Martineti V., Becherini L., Mark M., Friedman E., Brandi M.L. MEN 1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1. Eur J Endocrinol. 142: 131-137, 2000. 180. Reginster J.Y., Minne H.W., Sorensen O.H., Hooper M., Roux C. Brandi M.L., Lund B., Ethgen D., Pack S., Roumagnac I., Eastell R., on behalf of the VERT Study Group. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. Osteoporos Int. 11: 83-91, 2000. 181. De Feo L., Colagrande S., Biagini C., Tonarelli A., Bisi G., Vaggelli L., Borrelli D., Cicchi P., Tonelli F., Amorosi A., Serio M., Brandi M.L. Parathyroid glands: combination of 99mTc MIBI scintigraphy and US for demonstration of parathyroid glands and nodules. Radiology. 214: 393-402, 2000. 182. Brown S.B., Brierley T.T., Palanisamy N., Salusky I., Goodman W., Brandi M.L., Drüeke T.B., Sarfati E., Ureña P., Chaganti R.S.K., Wesley Pike J. Arnold A. Vitamin D receptor as a candidate tumor-suppressor gene in severe hyperparathyroidism of uremia. J Clin Endocrinol Metab. 85: 868-872, 2000. 183. Masi L., Malentacchi C., Benvenuti S., Amedei A., Bigozzi U., Montali E., Brandi M.L. In vitro expression of pro1(I) collagen mRNA by human pre-osteoclastic cells. J Endocrinol Invest. 23: 1-4, 2000. 184. Giavaresi G., De Terlizzi F., Gnudi S., Cadossi R., Nicoli Aldini N., Fini M., Rocca M., Ripamonti C., Brandi M.L., Giardino R. Discriminant capacity of quantitative ultrasound versus dual X-ray absorptiometry to determine cancellous bone loss in ovariectomized rats. Bone. 26: 297-303, 2000. 185. Tonelli F, Spini S., Tommasi M., Gabbrielli G., Amorosi A., Brocchi A., Brandi M.L. Intraoperative parathormone measurement in patients with multiple endocrine neoplasia type I syndrome and hyperparathyroidism. World J Surg. 24: 556-563, 2000. 186. Barletta G., De Feo M.L., Del Bene R., Lazzeri C., Vecchiarino S., La Villa G., Brandi M.L., Franchi F. Cardiovascular effects of parathyroid hormone: a study in healthy subjects and normotensive patients with mild primary hyperparathyroidism. J Clin Endocrinol Metab. 85: 1815-1821, 2000. 187. Brandi M.L. Raloxifene reduces vertebral fracture risk in osteoporosis. Clin Exp Rheumatol. 18: 309-310, 2000. 188. Falcini F., Bindi G., Ermini M., Galluzzi F., Poggi G., Rossi S., Masi L., Cimaz R., Brandi M.L. Comparison of quantitative calcaneal ultrasound and dual energy X-ray absorptiometry in postmenopausal women with the evaluation of osteoporotic risk in children with chronic rheumatic diseases. Calcif Tissue Int. 67: 19-23, 2000. 189. Semprini S., Mango R., Brancati F., Dallapiccola B., Becherini L., Novelli G., De Lorenzo A., Brandi M.L., Gennari L. Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women. Calcif Tissue Int. 67: 93-94, 2000. 190. Becherini L., Gennari L., Masi L., Mansani R., Massart F., Morelli A., Falchetti A., Gonnelli S., Fiorelli G., Tanini A., Brandi M.L. Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women. Hum Mol Genet. 9: 2043-2050, 2000. 191. Benvenuti S., Brandi M.L. Corticosteroid-induced osteoporosis: Pathogenesis and prevention. Clin Exp Rheumatol. 18: S64-S66, 2000. 192. Reginster J.Y., Bruyere O., Audran M., Avouac B., Body J.J., Bouvenot G., Brandi M.L., Gennari C., Kaufman J.M., Lemmel E.M., Vanhaelst L., Weryha G., Devogelaer J.P. Do estrogens effectively prevent osteoporosis-related fractures? Calcif Tissue Int. 67: 191-194, 2000. 193. Bianchi M.L., Cimaz R., Bardare M., Zulian F., Lepore L., Boncompagni A., Galbiati E., Corona F., Luisetto G., Giuntini D., Picco P., Brandi M.L., Falcini F. Efficacy and safety of alendronate for the treatment of osteoporosis in diffuse connective tissue diseases in children: a prospective multicenter study. Arthritis Rheum. 43: 1960-1966, 2000. 194. Mancini L., Moradi-Bidhendi N., Brandi M.L., Perretti M., MacIntyre I. Modulation of the effects of osteoprotegerin (OPG) ligand in a human leukemic cell line. Biochem Biophys Res Commun. 279: 391-397, 2000. 195. Gheri R.G., Colli E., Mansani R., Brandi M.L. Subclinical hyperthyroidsm and hypothyroidsm. Recenti Prog Med. 91: 588-593, 2000. 196. Brandi M.L. New perspectives in the prevention and treatment of glucocorticoid-induced osteoporosis. Clin Exp Rheumatology 18: S74-S78, 2000. 197. Picariello L., Benvenuti S., Recenti R., Formigli L., Falchetti A., Morelli A., Masi L., Tonelli F., Cicchi P., Brandi M.L. Microencapsulation of human parathyroid cells: an “in vitro” study. J Surg Res. 96: 81-89, 2001. 198. Massart F., Becherini L., Gennari L., Facchini V., Genazzani A.R., Brandi M.L. Genotype distribution of estrogen receptor-α gene polymorphisms in Italian women with surgical uterine leiomyomas. Fertil Steril 75: 567-570, 2001. 199. Locchi F., Tommasi M., Brandi M.L., Borrelli D., Cicchi P., Tonelli F., Meldolesi U. The importance of the unsuppressed glands in the study of intact parathyroid hormone disappearance after parathyroid adenomectomy. Eur J Endocrinol 144: 353-362, 2001. 200. Masi L. Becherini L., Gennari L., Amedei A., Colli E., Falchetti A., Farci M., Silvestri S., Gonnelli S., Brandi M.L. Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk. 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Reid I.R., Brown J.P., Burckhardt P., Horowitz Z., Richardson P., Trechsel U., Widmer A., Devogelaer J-P., Kaufman J-M., Jaeger P., Body J-J., Meunier P.J., Brandi M.L., Broell J., Di Micco R., Genazzani A.R., Happ J., Hooper M.J., Ittner J., Leb G., Mallmin H., Murray T., Ortolani S., Rubinacci A., Sääf M., Samsioe G., Verbruggen L. Intravenuous zoledronic acid in postmenopausal women with low bone mineral density. N Engl J Med. 346: 653-661, 2002. 212. Gennari C., Gonnelli S., Bruni D., Gennari L., Brandi M.L. PTH in the pathogenesis and treatment of glucocorticoid-induced osteoporosis. Front Horm Res 30: 184-197, 2002. 213. Meunier P.J., Slosman D.O., Delmas P.D., Sebert J.L., Brandi M.L., Albanese C., Lorenc R., Pors-Nielsen S., De Vernejoul M.C., Roces A., Reginster J.Y. Strontium ranelate: dosedependent effects in established postmenopausal vertebral osteoporosis: the STRATOS 2-year randomized placebo controlled trial. J Clin Endocrinol. Metab 87: 2060-2066, 2002. 214. Imanishi Y., Tahara H., Palanisamy N., Spitalny S., Salusky I.B., Goodman W., Brandi M.L., Drüeke T.B., Sarfati E., Ureña P., Chaganti R.S., Arnold A. Clonal chromosomal defects in the molecular pathogenesis of refractory hyperparathyroidism of uremia. J Am Soc Nephrol 13: 1490-1498, 2002. 215. Gennari L., Becherini L., Falchetti A., Masi L., Massart F., Brandi M.L. Genetics of osteoporosis: role of steroid hormone receptor gene polymorphisms. J Steroid Biochem Mol Biol 81: 1-24, 2002. 216. Fiorelli G., Picariello L., Martineti V., Tognarini I., Tonelli F., Brandi M.L. Estrogen metabolism in human colorectal cancer cells. J Steroid Biochem Mol Biol 81: 281-289, 2002. 217. Corsi A.M., Ferrucci L., Gozzini A., Tanini A., Brandi M.L. Myostatin polymorphisms and age-related sarcopenia in the Italian population. J Am Geriatric Soc 50: 1463, 2002. 218. Vezzoli G., Tanini A., Ferrucci L., Soldati L., Bianchin C., Franceschelli F., Malentacchi C., Porfirio B., Adamo D., Terranegra A., Falchetti A., Cusi D., Bianchi G., Brandi M.L. Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. J Am Soc Nephrol 13: 2517-2523, 2002. 219. Masi L., Cimaz R., Simonini G., Bindi G., Stagi S., Gozzini A., Malentacchi C., Brandi M.L., Falcini F. Association of low bone mass with vitamin D receptor gene and calcitonin receptor gene polymorphisms in juvenile idiopathic arthritis. J Rheumatol 29: 2225-2231, 2002. 220. Ioannidis J.P., Stavrou I., Trikalinos T.A., Zois C., Brandi M.L., Gennari L., Albagha O., Ralston S.H., Tsatsoulis A., ER-alpha Genetics Meta-Analysis Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a metaanalysis. J Bone Miner Res 17: 2048-2060, 2002. 221. Ghinoi V., Brandi M.L. Clodronate: mechanisms of action on bone remodelling and clinical use in osteometabolic disorders. Expert Opin Pharmacother 3: 1643-1656, 2002. 222. Massart F., Paolini S., Piscitelli E., Brandi M.L., Solaini G. Dose-dependent inhibition of mitochondrial ATP synthase by 17ß-estradiol. Gynecol Endocrinol 16: 373-377, 2002. 223. Gennari L., Becherini L., Falchetti A., Bandini S., Salvadori M., Carabellese S., Borgatti P., Lusenti T., Surian M., Dozio B., Brancaccio D., Carpani P., Vallino F., Corghi E., Tanini A., Gozzini A., Franceschelli F., Brandi M.L. Genetic polymorphisms in uremic secondary hyperparathyroidism. Ital J Min Electrol Metab 15: 1-7, 2002. 224. Brandi M.L. Risk of fractures and their complications. Medicographia 24: 297-302, 2002. 225. Brandi M.L. Management of post-menopausal osteoporosis: something new on the horizon? J Endocrinol Invest 26: 170-173, 2003. 226. Francesco C., Brandi M.L., Tonelli F., Zuckermann M., Cariati A. carcinoma. Am J Surg Pathol 27: 1176-1177, 2003. 227. Picariello L., Fiorelli G., Martineti V., Tognarini I., Pampaloni B., Tonelli F., Brandi M.L. Growth response of colon cancer cell lines to selective estrogen modulators. Anticancer Res 23: 2419-2424, 2003. 228. Cioppi F., Falchetti A., Masi L., Brandi M.L. Dynamic investigation for evaluation of calcium metabolism and parathyroid function. J Endocrinol Invest 26: 83-91, 2003. 229. Tonelli F., Ficari F., Valanzano R., Brandi M.L. Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis with raloxifene. Tumori 89: 391-396, 2003. Papillary thyroid 230. Massart F., Becherini L., Marini F., Noci I., Piciocchi L., Del Monte F., Masi L., Falchetti A., Tanini A., Scarselli G., Brandi M.L. Analysis of estrogen receptor (ERα and ERβ) and progesterone receptor (PR) polymorphisms in uterine leiomyomas. Med. Sci. Monit 9: BR25-30, 2003. 231. Tanzi M.C., Farè S., Petrini P., Tanini A., Piascitelli E., Zecchi-Orlandini S., Brandi M.L. Cytocompatibility of polyurethane foams as biointegrable matrices for the preparation of scaffolds for bone reconstruction. J Appl Biomat Biomech 1: 58-66, 2003. 232. Cetta F., Brandi M.L., Tonelli F., Zuckermann M., Cariati A. Papillary Thyroid Carcinoma. Am J Surg Pathol 27: 1176-1179, 2003. 233. Harrington J.T., Ste-Marie L.G., Brandi M.L., Civitelli R., Fardellone P., Grauer A., Barton I., Boonen S. Risedronate rapidly reduces the risk for nonvertebral fractures in women with postmenopausal osteoporosis. Calcif Tissue Int 74: 129-135, 2004. 234. Khosla S., Riggs B.L., Atkinson E.J., Oberg A.L., Mavilia C., Del Monte F., Melton L.J. 3rd, Brandi M.L. Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men. J Clin Endocrinol Metab 89: 1808-1816, 2004. 235. Masi L., Simonini G., Piscitelli E., Del Monte F., Giani T., Cimaz R., Vierucci S., Brandi M.L., Falcini F. Osteoprotegerin (OPG)/RANK-L system in juvenile idiopathic arthritis: is there a potential modulating role for OPG/RANK-L in bone injury? J Rheumatol 31: 986-991, 2004. 236. Falchetti A., Di Stefano M., Marini F., Del Monte F., Mavilia C., Strigoli D., De Feo M.L., Isaia G., Masi L., Amedei A., Cioppi F., Ghinoi V., Maddali Bongi S., Di Fede G., Sferrazza C., Rini G.B., Melchiorre D., Matucci-Cerinin M., Brandi M.L. Two novel mutation at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget’s disease of bone (PDB). J Bone Miner Res 19: 1013-1017, 2004. 237. Brandi M.L., Falchetti A. Genetics of primary hyperparathyroidism. Urol Int 72: 11-16, 2004. 238. Gennari L., Masi L., Merlotti D., Picariello L., Falchetti A., Tanini A., Mavilia C., Del Monte F., Gonnelli S., Lucani B., Gennari C., Brandi M.L. A polymorphic CYP19 TTTA repeat influences aromatase activity and estrogen levels in elderly men: effects on bone metabolism. J Clin Endocrinol Metab 89: 2803-2810, 2004. 239. Bacciottini L., Brandi M.L. Foods and new foods – The role of nutrition in skeletal health. J Clin Gastroenterol 38: S115-117, 2004. 240. Avnet S., Cenni E., Granchi D., Perut F., Amato I., Battistelli L., Giunti A., Baldini N., Brandi M.L. Isolation and characterization of a new cell line from a renal carcinoma bone metastatis. Anticancer Res 24: 1705-1711, 2004. 241. Granchi D., Amato I., Battistelli L., Avnet S., Capaccioli S., Papucci L., Donnini M., Pellacani A., Brandi M.L., Giunti A., Baldini N. In vitro blockade of receptor activator of nuclear factorkappaB ligand prevents osteoclastogenesis induced by neuroblastoma cells. Int J Cancer 111: 829-838, 2004. 242. Bacciottini L., Tanini A., Falchetti A., Masi L., Franceschelli F., Pampaloni B., Giorgi G., Brandi M.L. Calcium bioavailability from a calcium-rich mineral water, with some observations on method. J Clin Gastroenterol 38: 761-766, 2004. 243. Brandi M.L. Calcaneal quantitative ultrasound as a reliable tool in assessing osteoporosis and its risk factors in a large cohort of the Italian population. Clin Exp Rheumatol 22: 553, 2004. 244. Picariello L., Tonelli F., Brandi M.L. Selective oestrogen receptor modulators in desmoid tumours. Expert Opin Investig Drugs 13: 1457-1468, 2004. 245. Ioannidis J.P., Ralston S.H., Bennet S.T., Brandi M.L., Grinberg D., Karassa F.B., Langdahl B., van Meurs J.B., Mosekilde L., Scollen S., Albagha O.M., Bustamante M., Carey A.H., Dunning A.M., Enjuanes A., van Leeuwen J.P.T:M., Mavilia C., Masi L., McGuigan F.E., Nogues X., Pols H.A., Reid D.M., Schuit S.C., Sherlock R.E., Uitterlinden A.G., GENOMOS Study Differential genetic effect of ESR1 gene polymorphism on osteoporosis outcomes. JAMA 292: 2105-2114, 2004. 246. Croppi E., Vitale C., Bevilacqua M., Borghi L., Caudarella R., Falchetti A., Gambaro G., Marangella M., Trinchieri A., Vezzoli G., Brandi M.L. Consensus statement on diagnosis of primary hypercalciuria. Clin Cases Min Bone Metab 1: 73-75, 2004. 247. Masi L., Winer K.K., Potts J.T., Brandi M.L. Management of hypoparathyroidism. Clin Cases Min Bone Metab 1: 127-128, 2004. 248. De Feo M.L., Serio M., Ladu C., Falchetti A., Masi L., Gozzini A., Marini F., Tanini A., Brandi M.L. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy sindrome (APECED): report on three cases from Southern Italy. Clin Cases Min Bone Metab 1: 147-149, 2004. 249. Masi L., Brandi M.L. The Italian Register of primary hypoparathyroidism. Clin Cases Min Bone Metab 1: 157-161, 2004. 250. Jork A., Glöckner H., Thürmer F., Ulrich F., Brandi M.L. hypoparathyroidism. Clin Cases Min Bone Metab 1: 163-166, 2004. 251. Massart F., Marini F., Menegato A., Del Monte F., Nuti M., Butitta F., Ferrari M., Balbarini A., Brandi M.L. Allelic genes involved in artery compliance and susceptibility to sporadic abdominal aortic aneurysm. J Steroid Biochem Mol Biol 92: 413-418, 2004. 252. Falchetti A., Marini F., Masi L., Brandi M.L. Genetic aspects of Paget’s disease of bone. Clin Cases Min Bone Metab 1: 197-201, 2004. 253. Ulivieri F.M., Falchetti A., Marini F., Brandi M.L., Piodi L.P., Crespi A., Verdoia C., Gerundini P. A familial case of Paget’s disease of bone with mutation at exon 8 of the sequestosome 1 (SQSTM1/p62) gene. Clin Cases Min Bone Metab 1: 231-233, 2004. 254. Bilezikian J.P., Brandi M.L., Rubin M., Silverberg S.J. Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features. J Intern Med 257: 6-17, 2005. 255. Tonelli F., Fratini G., Falchetti A., Nesi G., Brandi M.L. Surgery for gastroenteropancreatic tumours in multiple endocrine neoplasia type 1: review and personal experience. J Intern Med 257: 38-49, 2005. 256. Ferolla P., Falchetti A., Filosso P., Tomassetti P., Tamburrano G., Avenia N., Daddi G., Puma F., Ribacchi R., Santeusiano F., Angeletti G., Brandi M.L. Thymic neuroendocrine carcinoma Cell therapies in (carcinoid) in multiple endocrine neoplasia type 1 syndrome: the Italian series. Endocrinol Metab 90: 2603-2609, 2005. J Clin 257. Falchetti A., Marini F., Del Monte F., Masi L., Carbonell Sala S., Ghinoi V., Franceschelli F., Tanini A., Tonelli F., Brandi M.L. Results of a national survey on multiple endocrine neoplasia syndrome type1 in Italy: a macroaggregate analysis. Clin Cases Min Bone Metab 2: 29-35, 2005. 258. Gennari L., Falchetti A., Bandini S., Carabellese S., Borgatti P., Lusenti T., Surian M.,Dozio B., Brancaccio D., Carpani P., Vallino F., Corghi E., Tanini A., Gozzini A., Franceschelli F., Brandi M.L. Genetic polymorphisms of vitamin D receptor and calcium sensing receptor gene in uremic secondary hyperparathyroidism: a multicentric italian study. Clin Cases Min Bone Metab 2: 37-41, 2005. 259. Falchetti A., Franchi A., Bordi C., Mavilia C., Masi L., Cioppi F., Recenti R., Picariello L., Marini F., Del Monte F., Ghinoi V., Martineti V., Tanini A,. Brandi M.L. Azidothymidine induces apoptosis and inhibits cell growth and telomerase activity of human parathyroid cancer cell in culture. J Bone Miner Res 20: 410-418, 2005. 260. Pampaloni B., Tanini A., Ginanneschi M., Bacciottini L., Bartolini E., Brandi M.L. Quercentin and trans-resveratrol phytoestrogens in Morellino di Scansano wine samples. Clin Cases Min Bone Metab 2: 43-45, 2005. 261. Cenni E., Perut F., Zuntini M., Granchi D., Amato I., Avnet S., Brandi M.L., Giunti A., Baldini N. Inhibition of angiogenic activity of renal carcinoma by an antisense oligonucleotide targeting fibroblast growth factor-2. Anticancer Res 25: 1109-1113, 2005. 262. Zonefrati R., Tanini A., Bartaloni J., Tognarini I., Galli G., Carossino A., Brandi M.L. The use of mouse ribs in organ culture improves the in vitro bone resorption assay. Clin Cases Min Bone Metab 2: 47-51, 2005. 263. Martineti V., Picariello L., Tognarini I., Carbonell Sala S., Gozzini A., Azzari C., Mavilia C., Tanini A., Falchetti A., Fiorelli G., Tonelli F., Brandi M.L. Erß is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components. Endocr Relat Cancer 12: 455-469, 2005. 264. Falchetti A., Gozzini A., Masi L., Martineti V., Bandini S., Brandi M.L. Allelic loss at the vitamin D receptor (VDR) locus in parathyroid tissue from one patient affected by refractory uremic hyperparathyroidism. Clin Cases Min Bone Metab 2: 53-55, 2005. 265. Delmas P.D., Khaltaev N., Arriagada M., Brandi M.L., Cannata J., Lau E., Lederman R., Lorenc R., Minne H., Morales-Torres J., Morii H., Sambrook P., Torralba T., Zanchetta J., Reginster J.Y. The Management of Postmenopausal Osteoporosis: A Position Paper of the World Health Origination Collaborating Center on Public Health Aspects of Rheumatic Diseases. J Musculoskelet Neuronal Interact 5: 105-109, 2005. 266. Falchetti A., Marini F., Tonelli F., Brandi M.L. Lessons from genes mutated in multiple endocrine neoplasia (MEN) syndromes. Ann Endocrinol 66: 195-205, 2005. 267. De Feo M.L., Colagrande S., Biagini C., Vaggelli L., Serio M., Brandi M.L. Diagnosis of primary hyperparathyroidism: bias of imaging evaluation in the absence of accurate clinical evaluation. Clin Cases Min Bone Metab 2: 61-63, 2005. 268. Simonini G., Masi L., Giani T., Piscitelli E., Cimaz R., Vierucci S., Brandi M.L. Falcini F. Osteoprotegerin serum levels in Kawasaki disease: an additional potential marker in predicting children with coronary artery involvement. J Rheumatol 32: 2233-2238, 2005. 269. Falchetti A., Di Stefano M., Marini F., Del Monte F., Gozzini A., Masi L., Tanini A., Amedei A., Carossino A., Isaia G., Brandi M.L. Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget’s disease of bone in an Italian family. Arthritis Res Ther 7: R1289-1295, 2005. 270. Masi L., Brandi M.L. Molecular, biochemical and cellular biology of PTH anabolic action. J Endocrinol Invest 28: 37-40, 2005. 271. Dennison E., Syddall H., Fall C., Brandi M.L., Cooper C., Hertfordshire Cohort Study Group. Evidence of Sexual Dimorphism in Relationships between estrogen receptor polymorphisms and bone mass: the Hertfordshire study. J Reumatol 32: 2400-2404, 2005. 272. Falchetti A., Marini F., Brandi M.L. Multiple Endocrine Neoplasia Type 1. Gene Rev. at Gene Tests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2005. 273. Carbonell Sala S., Masi L., Marini F., Del Monte F., Falchetti A., Franceschelli F., Brandi M.L. Genetics and pharmacogenetics of osteoporosis. J Endocrinol Invest 28: 2-7, 2005. 274. Martineti V., Carbonell Sala S., Masi L., Falchetti A., Brandi M.L. The vitamin D receptor: biological and molecular properties. Clin Cases Min Bone Metab 3: 11-22, 2006. 275. Nuti R., Bianchi G., Brandi M.L., Caudarella R., D’Erasmo E., Fiore C., Isaia G.C., Luisetto G., Muratore M., Oriente P., Ortolani S. Superiority of alfacalcidol compared to vitamin D plus calcium in lumbar bone mineral density in postmenopausal osteoporosis. Rheumatol Int 26: 445-453, 2006. 276. Brandi M.L., Collin-Osdoby P. Vascular biology and the skeleton. J Bone Miner Res 21:183192, 2006. 277. Reginster J.Y., Abadie E., Delmas P., Rizzoli R., Dere W., der Auwera P., Avouac B., Brandi M.L., Daifotis A., Diez-Perez A., Calvo G., Johnell O., Kaufman J.M., Kreutz G., Laslop A., Lekkerkerker F., Mitlak B., Nilsson P., Orloff J., Smillie M., Taylor A., Tsouderos Y., Ethgen D., Flamion B. Recommendations for an update of the current (2001) regulatory requirements for registration of drugs to be used in the treatment of osteoporosis in postmenopausal women and in men. Osteoporos Int 17: 1-7, 2006. 278. Lussana F., Faioni E.M., Mavilia C., Bucciarelli P., Brandi M.L., Cattaneo M. Association of estrogen receptor-alpha genepolymorphisms with venous thrombosis. Haematologica 91: 279280, 2006. 279. Reid D.M., Hosking D., Kendler D., Brandi M.L., Wark J.D., Weryha G., Marques-Neto J.F., Gaines K.A., Verbruggen N., Melton M. Alendronic Acid produces Greater Effects than Risedronic Acid on Bone Density and Turnover in Postmenopausal Women with Osteoporosis: Results of FACTS-International (fosamax actonel comparison trials). Clinical Drug Investigation 26: 63-74, 2006. 280. Ralston S.H., Uitterlinden A.G., Brandi M.L., Balcells S., Langdahl B.L., Lips P., Lorenc R., Obermayer-Pietsch B., Scollen S., Bustamante M., Husted L.B., Carey A.H., Diez-Perez A., Dunning A.M., Falchetti A., Karczmarewicz E., Kruk M., van Leeuwen J.P., van Meurs J.B., Mangion J., McGuigan F.E., Mellibovsky L., Del Monte F.D., Pols H.A., Reeve J., Reid D.M., Renner W., Rivadeneira F., van Schoor N.M., Sherlock R.E., Ioannidis J.P., GENOMOS Investigators Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study. PloS Med 3: e90, 2006. 281. Luisi S., Galleri L., Marini F., Ambrosini G., Brandi M.L., Petraglia F. Estrogen receptor gene polymorphisms are associated with recurrence of endometriosis. Fertil Steril 85: 764-766, 2006. 282. Galli G., Zonefrati R., Gozzini A., Mavilia C., Martineti V., Tognarini I., Nesi G., Marcucci T., Tonelli F., Tommasi M., Casini Raggi C., Pinzani P., Brandi M.L. Characterization of the functional and growth properties of long-term cell cultures established from a human somatostatinoma. Endocr Relat Cancer 13: 79-93, 2006. 283. Picariello L., Sala S.C., Martineti V., Gozzini A., Aragona P., Tognarini I., Paglierani M., Nesi G., Brandi M.L., Tonelli F. A comparison of methods for the analysis of low abundance proteins in desmoid tumor cells. Anal Biochem May 3, 2006. 284. Silvestri S., Bloch Thomsen A., Gozzini A., Bagger Y., Christiansen C., Brandi M.L. Estrogen receptor alpha and beta polymorphisms: is there an association with bone mineral density, plasma lipids, and response to postmenopausal hormone therapy? Menopause 13: 451-461, 2006. 285. Nuzzo V., Tauchmanova L., Falchetti A., Faggiano A., Marini F., Piantadosi S., Brandi M.L., Leopardi L., Colao A. MEN 1 family with a novel frameshift mutation. J Endocrinol Invest. 29: 450-456, 2006. 286. Tonelli F., Fratini G., Nesi G., Tommasi MS., Batignani G., Falchetti A., Brandi M.L. Pancreatectomy in Multiple Endocrine Neoplasia Type 1-Related Gastrinomas and Pancreatic Endocrine Neoplasias. Ann Surg 244: 61-70, 2006. 287. Avnet S., Cenni E., Gancitano G., Perut F., Brandi M.L., Giunti A., Baldini N., In vitro effects of interferon-alpha on different cellular elements existing in a bone metastatis of renal cell carcinoma. EORS 16th Annual Meeting Transaction Vol. 16, 2006. 288.