CURRICULUM VITAE
The Johns Hopkins University School of Medicine
ANIRBAN MAITRA, M.B.B.S.
October 21, 2010
Date
DEMOGRAPHIC INFORMATION
Current Appointments:
University:
Professor of Pathology (11/2010)
Professor of Oncology (secondary) (11/2010)
Affiliate, McKusick-Nathans Institute of Genetic Medicine
Hospital:
Pathologist, The Johns Hopkins Hospital
Personal Data:
Business Address:
CRB-2 Room 345
1550 Orleans Street
Baltimore, MD 21231
Phone
410 502 8191
Fax
410 614 0671
Email
amaitra1@jhmi.edu
Education and Training:
1990-1996
Bachelor of Medicine, Bachelor of Surgery (MBBS), All Indian Institute of Medical Sciences,
New Delhi, India - Medicine
1996-1998
Residency, University of Texas Southwestern Medical Center, Dallas - Anatomic Pathology
1998-1999
Research Fellow, University of Texas Southwestern Medical Center, Dallas - Molecular
Pathology
1999-2000
Clinical Fellow, University of Texas Southwestern Medical Center, Dallas - Pediatric Pathology
2000-2001
Residency, University of Texas Southwestern Medical Center, Dallas - Anatomic Pathology
2001-2002
Clinical/Research Fellow, Johns Hopkins University School of Medicine, Baltimore Gastrointestinal/Liver Pathology.
Professional Experience:
07/2002-06/2003 Instructor, Gastrointestinal Pathology, Johns Hopkins University School of Med, Baltimore.
07/2002-present Affiliate, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins Univ., Baltimore
06/2003-12/2005 Assistant Prof, Pathology, Johns Hopkins University School of Medicine, Baltimore.
06/2003-12/2005 Assistant Prof, Oncology, Johns Hopkins University School of Medicine, Baltimore.
07/2005-present Graduate Faculty, Pathobiology Program, Johns Hopkins University School of Med, Baltimore
01/2006-11/2010 Associate Professor, Pathology, Johns Hopkins Univ School of Medicine, Baltimore.
01/2006-11/2010 Associate Professor, Oncology, Johns Hopkins University School of Medicine Baltimore.
11/2010 Professor of Pathology, Johns Hopkins Univ School of Medicine, Baltimore.
11/2010Professor of Oncology, Johns Hopkins Univ School of Medicine, Baltimore.
Maitra, Anirban
RESEARCH ACTIVITIES
Peer Reviewed Original Research Publications
1.
Maitra A, Hirany SV, Jialal, I. Comparison of two assays for measuring LDL cholesterol. Clin Chem. 1997;
43:1040-7.
2.
Yashima K, Maitra A, Rogers BB, Timmons CF, Rathi A, Pinar H, Wright WE, Gazdar AF. Expression of
the RNA component of telomerase during human development and differentiation. Cell Growth Diff. 1998;
9:805-13.
3.
Yashima K, Maitra A, Timmons CF, Rogers BB, Pinar H, Shay JW, Gazdar A. Expression of the RNA
component of telomerase in Wilms tumor and nephrogenic rest recapitulates renal embryogenesis. Hum
Pathol. 1998; 29:536-42.
4.
Yashima K, Milchgrub S, Gollahon LS, Maitra A, Saboorian MH, Shay JW, Gazdar A. Telomerase enzyme
activity and RNA expression during the multistage pathogenesis of breast carcinoma. Clin Cancer Res. 1998;
4:229-34.
5.
Maitra A, Yashima K, Timmons CF, Rogers BB, Rathi A, Shay JW, Gazdar AF. The RNA component of
telomerase as a marker of biologic potential and clinical outcome in childhood neuroblastic tumors. Cancer.
1999; 85:741-9.
6.
Maitra A, Amirkhan R, Saboorian MH, Frawley W, Ashfaq R. Survival in small cell lung carcinoma is
independent of Bcl-2 expression. Hum Pathol. 1999; 30:712-7.
7.
Maitra A, Wistuba II, Virmani AK, Sakaguchi M, Park I, Stuckey A, Milchgrub S, Gibbons SD, Minna JD,
Gazdar AF. Enrichment of epithelial cells for molecular studies. Nature Med. 1999; 5:459-63.
8.
Maitra A, Salahuddin S, Timmons CF, Gazdar AF. Allelotyping nephrogenic rests: the putative precursor
lesions of Wilms tumors. Ped Develop Pathol. 1999; 2:488-9.
9.
Maitra A, Wistuba II, Gibbons DG, Gazdar AF, Albores-Saavedra J. Allelic losses at chromosome 3p are
seen in human papilloma virus 16 associated transitional cell carcinoma of the cervix. Gynecol Oncol. 1999;
74:361-8.
10.
Maitra A, Tavassoli FA, Albores-Saaverdra J, Behrens C, Wistuba II, Weinberg AG, Bryant D, Rogers B,
Saboorian M, Gazdar A. Molecular abnormalities associated with secretory carcinomas of the breast. Human
Pathol. 1999; 30:1435-40.
11.
Lindberg G, Maitra A, Saboorian MH, Gokaslan ST, Albores-Saavedra J. Low grade fibromyxoid sarcoma:
fine-needle aspiration cytology with histologic, cytogenetic, immunohistochemical, and ultrastructural
correlation. Cancer Cytopathol. 1999; 87:75-82.
12.
Euhus DM, Maitra A, Wistuba II, Alberts A, Albores-Saavedra J, Gazdar AF. Loss of heterozygosity at 3p
in benign lesions preceding invasive breast cancer. J Surg. Res. 1999; 83:13-18.
13.
Shivapurkar N, Sood S, Wistuba II, Virmani AK, Maitra A, Milchgrub S, Minna JD, Gazdar AF. Multiple
regions of chromosome 4 demonstrating allelic losses in breast carcinomas. Cancer Res. 1999; 59:3576-80.
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Maitra, Anirban
14.
Park I, Wistuba II, Maitra A, Milchgrub S, Virmani AK, Gazdar AF. Multiple clonal abnormalities in the
bronchial epithelium of patients with lung cancer. J Natl Cancer Inst. 1999; 91:1863-8.
15.
Euhus DM, Maitra A, Wistuba II, Ashfaq R, Alberts A, Gibbons D, Gazdar A. Use of archival fine needle
aspirates for the allelotyping of tumors. Cancer Cytopathol. 1999; 87:372-9.
16.
Maitra A, Molberg KH, Albores-Saavedra J, Lindberg GM. Loss of Dpc4 expression in colonic
adenocarcinomas correlates with the presence of metastatic disease. Am J Pathol. 2000; 157:1105-11.
17.
Maitra A, Ashfaq R, Saboorian MH, Gokaslan ST. The role of fine-needle aspiration biopsy in the primary
diagnosis of mesenchymal lesions: a community hospital-based experience. Cancer Cytopathol. 2000;
90:178-85.
18.
Maitra A, Krueger JE, Tascilar M, Klimstra DS, Hruban RH, Angeles-Angeles A, Albores-Saavedra J.
Carcinoid tumors of the extrahepatic bile ducts: a study of seven cases. Am J Surg Pathol. 2000; 24:1501-10.
19.
Lin WM, Ashfaq R, Michalopulos EA, Maitra A, Gazdar AF, Muller CY. Molecular Papanicolaou tests in
the 21st century: Molecular analyses with fluid-based Papanicolaou technology. Am J Obstet Gynecol. 2000;
183:39-45.
20.
Behrens C, Travis LB, Wistuba II, Davis S, Maitra A, Clarke EA, Lynch CF, Glimelius B, Wiklund T,
Tarone R, Gazdar A. Molecular changes in second primary lung and breast cancers after therapy for
Hodgkin's disease. Cancer Epidemiol Biomarkers Preven. 2000; 9:1027-35.
21.
Wistuba II, Berry J, Behrens C, Maitra A, Shivapurkar N, Milchgrub S, Mackay B, Minna JD, Gazdar AF.
Molecular changes in the bronchial epithelium of patients with small cell lung cancer. Clin Cancer Res.
2000; 6:2604-10.
22.
Krueger JE, Maitra A, Albores-Saavedra J. Inherited medullary microcarcinoma of the thyroid: a study of 11
cases. Am J Surg Pathol. 2000; 24:853-8.
23.
Virmani AK, Rathi A, Zochbauer-Muller S Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM,
Thunnisen F, Minna JD, Gazdar AF. Promoter methylation and silencing of the retinoic acid receptor-beta
gene in lung carcinomas. J Natl Cancer Inst. 2000; 92:1303-7.
24.
Maitra A, Roberts H, Weinberg AG, Geradts J. Loss of p16(INK4a) expression correlates with decreased
survival in pediatric osteosarcomas. Int J Cancer (Predictive Oncology). 2001; 95:34-8.
25.
Maitra A, Wistuba II, Washington C, Virmani AK, Ashfaq R, Milchgrub S, Gazdar A, Minna JD. Highresolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss
of heterozygosity and a discontinuous pattern of allele loss. Am J Pathol. 2001; 159:119-30.
26.
Maitra A, Wanzer D, Weinberg AG, Ashfaq R. Amplification of the HER-2/neu Oncogene is Uncommon in
Pediatric Osteosarcomas. Cancer. 2001; 92:677-83.
27.
Maitra A, Roberts H, Weinberg AG, Geradts J. Aberrant expression of tumor suppressor proteins in the
Ewing family of tumors. Archives Pathol Lab Med. 2001; 12:1207-12.
28.
Maitra A, Rathi A, Ashfaq R, Sagalowsky A, Gazdar AF. Expression of the RNA component of human
telemorase (hTR) in ThinPrep preparations from bladder washings. Cancer Cytopathol. 2001; 93:73-9.
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Maitra, Anirban
29.
Maitra A, Murakata L, Albores-Saavedra J. Immunoreactivity for hepatocyte paraffin 1 antibody in hepatoid
adenocarcinomas of the gastrointestinal tract. Am J Clin Pathol. 2001; 115:689-94.
30.
Maitra A, Hruban RH, Offerhaus GJ, Tescilar M, Albores-Saavedra J. Small cell carcinoma of the
gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases. Am J
Surg Pathol. 2001; 25:595-601.
31.
Maitra A, McKenna RW, Weinberg AG, Schneider NR, Kroft SH. Precursor B-cell lymphoblastic
lymphoma. A study of nine cases lacking blood and bone marrow involvement and review of the literature.
Am J Clin Pathol. 2001; 115:868-75.
32.
Shivapurkar N, Maitra A, Milchgrub S, Wistuba II, Gazdar AF. Deletions of chromosome 4 occur early
during the pathogenesis of colorectal carcinoma. Hum Pathol. 2001; 32:169-77.
33.
Zöchbauer-Müller S, Fong KM, Maitra A, Lam S, Geradts J, Ashfaq R, Virmani AK, Milchgrub S, Gazdar
AF, Minna JD. 5’ CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung
and breast cancer. Cancer Res (Advances in Brief). 2001; 61:3581-5.
34.
Wistuba II, Tang M, Maitra A, Alvarez H, Troncoso P, Pimentel F, Gazdar AF. Genome-wide allelotyping
analysis reveals multiple sites of allelic loss in gallbladder carcinoma. Cancer Res. 2001; 61:3795-800.
35.
Xu XL, Wu LC, Du F, Davis A, Peyton M, Tomizawa Y, Maitra A, Tomlinson G, Gazdar AF, Weissman
BE, Bowcock AM, Baer R, Minna JD. Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor
suppressor region, in breast and lung cancers. Cancer Res. 2001; 61:7943-9.
36.
Maitra A, Gazdar AF, Moore TO, Moore AY. Loss of heterozygosity analysis of cutaneous melanoma and
benign melanocytic nevi: laser capture microdissection demonstrates clonal genetic changes in acquired
nevocellular nevi. Hum Pathol. 2002; 33:191-7.
37.
Maitra A, Domiati-Saad R, Yost N, Cunningham G, Rogers BB, Bennett MJ. Absence of the G1528C
(E474Q) mutation in the alpha-subunit of the mitochondrial trifunctional protein in women with acute fatty
liver of pregnancy. Pediatr Res. 2002; 51:658-61.
38.
Maitra A, Iacobuzio-Donahue C, Sohn TA, Argani P, Meyer R, Yeo CJ, Ayman R, Cameron JL, Goggins M,
Kern SE, Ahsfaq R, Hruban RH, Wilentz RE. Immunohistochemical validation of a novel epithelial and a
novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: Sea
urchin fascin homolog and heat shock protein 47. Am J Clin Pathol. 2002; 118:52-9.
39.
Maitra A, Ashfaq R, Hruban RH, Wilentz RE. Cyclooxygenase 2 expression in pancreatic adenocarcinoma
and pancreatic intraepithelial neoplasia: an immunohistochemical analysis with automated cellular imaging.
Am J Clin Pathol. 2002; 118:194-201.
40.
VanHeek NT, Meeker A, Kern SE, Yeo CJ, Lillemore KD, Cameron JL, Offerhaus JA, Hicks JL, Wilentz
RE, Goggins MG, DeMarzo AM, Hruban RH, Maitra A. Telomere shortening is nearly universal in
Pancreatic Intraepithelial Neoplasia. Am J Pathol. 2002; 161:1541-7.
41.
Iacobuzio-Donahue CA, Maitra A, Sheng-Ong GL, van Heek T, Ashfaq R, Meyer R, Walter K, Berg K,
Hollingsworth MA, Cameron JL, Yeo CY, Kern SE, Goggins M, Hruban RH. Discovery of novel tumor
markers of pancreatic cancer using global gene expression technology. Am J Pathol. 2002; 160:1239-49.
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Maitra, Anirban
42.
Wistuba II, Ashfaq R, Maitra A, Pimentel F, Troncoso P, Alvarez H. Fragile histidine triad gene
abnormalities in the pathogenesis of gallbladder carcinoma. Am J Pathol. 2002; 160:2073-9.
43.
Wistuba II, Maitra A, Carrasco R, Tang M, Troncoso P, Minna JD, Gazdar AF. High resolution chromosome
3p, 8p, 9q and 22q allelotyping analysis in the pathogenesis of gallbladder carcinoma. Br J Cancer. 2002;
87:432-40.
44.
Harada K, Toyooka S, Maitra A, Mastrangelo D, Timmons CF, Tomlinson GE, Gazdar AF. Aberrant
promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines. Oncogene.
2002; 21:4345-9.
45.
Toyooka KO, Toyooka S, Maitra A, Feng Q, Kiviat NC, Smith A, Minna JD, Ashfaq R, Gazdar AF.
Establishment and validation of real-time polymerase chain reaction method for CDH1 promoter methylation.
Am J Pathol. 2002; 161:629-34.
46.
Torbenson MS, Wang J, Choti M, Ashfaq R, Maitra A, Wilentz RE, Boitnott J. Hepatocellular carcinomas
show abnormal expression of fibronectin protein. Mod Pathol. 2002; 15:826-30.
47.
Torbenson MS, Marinopoulos S, Dang DT, Chota M, Ashfaq R, Maitra A, Boitnott J, Wilentz R. Smad4
overexpression in hepatocellular carcinoma is strongly associated with transforming growth factor beta II
receptor immunolabeling. Hum Pathol. 2002; 33:871-6.
48.
Harada K, Toyooka S, Shivapurkar N, Maitra A, Reddy J, Matta H, Miyajima K, Timmons CF, Tomlinson
GE, Mastrangelo D, Hay RJ, Chaudhary PM, Gazdar AF. Deregulation of caspase 8 and 10 expression in
pediatric tumors and cell lines. Cancer Res. 2002; 62:5897-901.
49.
Iacobuzio-Donahue CA*, Maitra A*, Olsen M, Lowe AW, Van Heek NT, Rosty C, Walter K, Sato N,
Parker A, Ashfaq R, Jaffee E, Ryu B, Jones J, Eshleman JR, Yeo CY, Cameron J, Kern SE, Hruban RH,
Brown PO, Goggins M. Exploration of global gene expression patterns in pancreatic adenocarcinoma using
cDNA microarrays. Am J Pathol. 2003; 162:1151-62 (*Equal contribution)
50.
Hansel DE, Rahman A, Hidalgo M, Lillemoe K, Schulick R, Ku J-L, Park J-G, Miyazaki K, Ashfaq R,
Wistuba II, Geradts J, Argani P, Maitra A. Identification of Novel Cellular Targets in Biliary Tract Cancers
using Global Gene Expression Technology Am J Pathol. 2003; 163:217-29.
51.
Hansel DE, Rahman A, Hermans J, de Krijger R, Ashfaq R, Yeo C, Cameron J, Hruban RH, Maitra A. Liver
metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C
expression. Mod Pathol. 2003; 16:652-9.
52.
Maitra A, Adsay V, Argani P, Iacobuzio-Donahue C, DeMarzo A, Yeo CJ, Cameron J, Hruban RH.
Multicomponent analysis of the pancreatic adenocarcinoma progression model using a Pancreatic
Intraepithelial Neoplasia tissue microarray. Mod Pathol. 2003; 16:902-12.
53.
Berman DM*, Karhadkar S*, Maitra A*, Parker A, Eshelman JR, Shimada Y, Beachy PA. Widespread
requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003; 425:846-51
(* Equal contribution).
54.
Hansel DE, Rahman A, Wehner S, Herzog V, Yeo CJ, Maitra A. Increased expression and processing of the
Alzheimer Amyloid Precursor Protein in pancreatic cancer may influence cellular proliferation. Cancer Res.
2003; 63:7032-7.
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Maitra, Anirban
55.
House MG, Wistuba II, Argani P, Guo M, Schulick RD, Hruban RH, Herman JG, Maitra A. Progression of
gene hypermethylation in gallstone disease leading to gallbladder cancer. Ann Surg Oncol. 2003; 10:882-9.
56.
Maitra A, Hansel DE, Argani P, Ashfaq R, Rahman A, Naji A, Deng S, Geradts J, Hawthorne LA, House
MG, Yeo CJ. Global expression analysis of well-differentiated pancreatic endocrine neoplasms using
oligonucleotide microarrays. Clin Cancer Res. 2003; 9:5988-95.
57.
Hansel DE, Ashfaq R, Rahman A, Yeo CJ, Maitra A. MAGE1 is expressed by a subset of pancreatic
endocrine neoplasms, and associated lymph node and liver metastases. Int J Gastrointestinal Cancer. 2003;
33:141-7.
58.
Hempen PM, Zhang L, Bansal RK, Iacobuzio-Donahue C, Murphy K, Maitra A, Vogelstein B, Whitehead
RH, Markowitz SD, Willson JKV, Yeo CY, Hruban RH, Kern SE. Evidence of selection for clones having
genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancer. Cancer Res.
2003; 63:994-9.
59.
Sato N, Maitra A, van Heek NT, Fukushima N, Matsubayashi H, Iacobuzio-Donahue C, Rosty C, Goggins
M. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer
Res. 2003; 63:4158-66.
60.
Ye D, Maitra A, Timmons CF, Leavey P, Ashfaq R, Ilaria, Jr. RL. The epidermal growth factor receptor
HER2 is not a major therapeutic target in Ewing’s sarcoma. J Ped Hem Oncol. 2003; 25:459-66.
61.
Sato N, Fukushima N, Maitra A, Matsubayashi H, Yeo C, Cameron J, Hruban RH, Goggins M. Discovery of
novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer
Res 2003; 63:3735-42.
62.
Sahin F, Maitra A, Argani P, Sato N, Maehara N, Montgomery E, Goggins M, Hruban R, Su GH. Loss of
Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol. 2003; 16:686-91.
63.
Rathi A, Virmani AK, Harada K, Timmons CF, Miajima K, Hay R, Mastraneglo D, Maitra A, Tomlinson
GE, Gazdar AF. Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric
neoplasms. Clin Cancer Res. 2003; 9:3674-8.
64.
Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue C, Sriuranpong V, Iso T,
Meszoely I, Wolfe M. Notch mediates TGF alpha-induced changes in epithelial differentiation during
pancreatic tumorigenesis. Cancer Cell. 2003; 3:565-76.
65.
McCarthy DM, Maitra A, Argani P, Rader AE, Faigel DO, Van Heek NT, Hruban RH, Wilentz RE. Novel
markers of pancreatic adenocarcinoma in fine-needle aspiration: mesothelin and prostate stem cell antigen
labeling increases accuracy in cytologically borderline cases. Appl Immunohistochem Mol Morphol. 2003;
11:238-43.
66.
Torbenson MS, Wang J, Abraham S, Maitra A, Boitnott JB. Bile ducts and ductules are positive for CD56
(N-CAM) in most cases of extrahepatic biliary atresia. Am J Surg Pathol. 2003; 27:1454-7.
67.
Rahman A, Maitra A, Yeo CJ, Cameron JL, Hruban RH, Ashfaq R, Hansel DE. Loss of p27 nuclear
expression in a prognostically favorable subset of well-differentiated pancreatic endocrine neoplasms. Am J
Clin Pathol. 2003; 120:685-90.
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Maitra, Anirban
68.
House MG, Guo MZ, Herman JG, Schulick RD, Cameron JL, Hruban RH, Maitra A, Yeo CJ. Aberrant
hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. Ann Surg. 2003; 238:42331.
69.
House MG, Guo MZ, Hooker CM, Herman JG, Schulick RD, Cameron JL, Hruban RH, Maitra A, Yeo CJ.
Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms.
Surgery. 2003; 134:902-8.
70.
Hingorani SR, Petricoin EF, Maitra A, King C, Jacobetz MA, Yoshiya K, Crawford HC, Putt ME, Jacks T,
Wright CV, Hruban RH, Lowy AM, Tuveson DA. Preinvasive and invasive ductal pancreatic cancer and its
early detection in the mouse. Cancer Cell. 2003; 4:437-50.
71.
Iacobuzio-Donahue C, Ashfaq R, Maitra A, Adsay V, Shen-Ong GL, Berg K, Hollingsworth M, Cameron J,
Yeo CJ, Kern SE, Goggins MG, Hruban RH. Highly expressed genes in pancreatic ductal adenocarcinomas:
a comprehensive characterization and comparison of the transcription profiles obtained from three major
technologies. Cancer Res. 2003; 63:8614-22.
72.
Hansel DE, Yeo CJ, Cameron J, Schulick RD, Montgomery EA, Wilentz RE, Maitra A. Expression of
neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tract. Am
J Surg Pathol. 2004; 28:347-56.
73.
Maitra A, Cohen Y, Gillespie SE, Mambo E, Fukushima N, Hoque MO, Shah N, Goggins M, Califano J,
Sidransky D, Chakaravarti A. The Human MitoChip: a high-throughput sequencing microarray for
mitochondrial mutation detection. Genome Res. 2004; 14:812-9.
74.
Goldenberg D, Rosenbaum E, Argani P, Wistuba II, Thuluvath PJ, Hidalgo M, Califano J, Maitra A. The
V599E BRAF mutation is uncommon in biliary tract cancers. Mod Pathol. 2004; 17:1386-91.
75.
Koopmann J, Thuluvath PJ, Zahurak M, Kristiansen TZ, Pandey A, Schulick RD, Argani P, Iacobelli S,
Goggins MG, Maitra A. Mac-2 binding protein is a diagnostic marker for biliary tract carcinoma. Cancer.
2004; 101:1609-15.
76.
Hansel DE, Rahman A, House MG, Ashfaq R, Berg K, Yeo CJ, Maitra A. Met proto-oncogene and insulinlike growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated
pancreatic endocrine neoplasms. Clin Cancer Res. 2004; 10:6152-8.
77.
Yeh C-N, Maitra A, Lee K-F, Jan Y-Y, Chen M-F. Thioacetamide-induced intestinal-type
cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human
cholangiocarcinoma. Carcinogenesis. 2004; 25:631-6.
78.
Koopmann J, Fedarko N, Jain A, Maitra A, Iacobuzio-Donahue CA, Yeo CJ, Hruban RH, Goggins MG.
Evaluation of osteopontin as a biomarker for pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers
Prev. 2004; 13:487-91.
79.
Sato N, Fukushima N, Maitra A, Iacobuzio-Donahue C, Matsubayashi H, Yeo C, Cameron J, Hruban RH,
Goggins M. Gene expression profiling identifies genes associated with invasive intraductal papillary
mucinous neoplasms of the pancreas. Am J Pathol. 2004; 164:903-14.
80.
Swierczynski SL, Maitra A, Abraham SC, Iacobuzio-Donahue CA, Ashfaq R, Cameron JL, Schulick RD,
Yeo CJ, Rahman A, Hinkle DA, Hruban RH, Argani P. Analysis of novel tumor markers in pancreatic and
biliary carcinomas using tissue microarrays. Hum Pathol. 2004; 35:357-66.
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Maitra, Anirban
81.
Parker AR, Leonard CP, Hua L, Francis R, Dhara S, Maitra A, Eshleman JR. A subgroup of microsatellite
stable colorectal cancers has elevated mutation rates and different responses to alkylating and oxidizing
agents. Br J Cancer. 2004; 90:1666-71.
82.
van Heek NT, Maitra A, Koopmann J, Fedarko N, Jain A, Rahman A, Iacobuzio-Donahue CA, Adsay V,
Ashfaq R, Yeo CJ, Cameron J, Offerhaus J, Hruban RH, Berg K, Goggins MG. Gene expression profiling
identifies markers of ampullary adenocarcinoma. Cancer Biol Ther. 2004; 3:651-6.
83.
Kristiansen TZ, Bunkenborg J, Gronborg M, Molina H, Thuluvath PJ, Argani P, Goggins MG, Maitra A,
Pandey A. A proteomic analysis of human bile. Mol Cell Proteomics. 2004; 3:715-28.
84.
Hruban RH, Takaori K, Klimstra D, Adsay NV, Albores-Saavdera J, Biankin A, Biankin S, Compton C,
Fukushima N, Furukawa T, Goggins M, Kato Y, Kloppel G, Longnecker D, Luttges J, Maitra A, Offerhaus
J, Shimuzu M, Yonezawa S. An illustrated consensus on the classification of Pancreatic Intraepithelial
Neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2004; 28:977-87.
85.
Gronborg M, Bunkenborg J, Kristiansen TZ, Jensen ON, Yeo CJ, Hruban RH, Maitra A, Goggins MG,
Pandey A. Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res. 2004; 3:1042-55.
86.
Amador M, Oppenheimer D, Perea S, Maitra A, Cusati G, Iacobuzio-Donahue C, Baker S, Ashfaq R,
Takimoto C, Forastiere A, Hidalgo M. An epidermal growth factor receptor intron 1 polymorphism mediates
response to epidermal growth factor receptor inhibitors. Cancer Res. 2004; 64:9139-43.
87.
Karhadkar S, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, Beachy PA.
Hedgehog signaling in prostate regeneration, neoplasia, and metastasis. Nature. 2004; 431:707-12.
88.
Cao D, Hustinx SR, Sui G, Bala P, Sato N, Martin S, Maitra A, Murphy KM, Cameron JL, Yeo CJ, Kern
SE, Goggins MG, Pandey A, Hruban RH. Identification of novel highly expressed genes in pancreatic ductal
adenocarcinomas through a bioinformatics analysis of expressed sequence tags. Cancer Biol Therapy. 2004;
3:1081-9.
89.
Hustinx SR, Cao D, Maitra A, Sato N, Martin ST, Sudhir D, Iacobuzio-Donahue C, Cameron JL, Yeo CJ,
Kern SE, Goggins MG, Mollenhauer J, Pandey A, Hruban RH. Differentially expressed genes in pancreatic
ductal adenocarcinomas identified through serial analysis of gene expression. Cancer Biol Ther. 2004;
3:1254-61.
90.
Henke RT, Haddad BR, Kim SE, Rone JD, Mani A, Jessup JM, Wellstein A, Maitra A, Riegel AT.
Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic
adenocarcinoma. Clin Cancer Res. 2004; 10:6134-42.
91.
Hansel DE, Rahman A, Wilentz RE, Shih I, McMaster MT, Yeo CJ, Maitra A. HLA-G upregulation in premalignant and malignant lesions of the gastrointestinal tract. Int J Gastrointestinal Cancer. 2005; 35:15-23.
92.
Hansel DE, Ashfaq A, Rahman A, Wanzer D, Yeo CJ, Wilentz RE, Maitra A. A subset of pancreatic
adenocarcinomas demonstrates co-amplification of topoisomerase II and Her-2/neu: Use of immunolabeling
and multi-color FISH for potential patient screening and treatment. Am J Clin Pathol. 2005; 123:28-35.
93.
Hustinx SR, Hruban RH, Leoni LM, Iacobuzio-Donahue C, Cameron JL, Yeo CJ, Brown PN, Argani P,
Ashfaq R, Fukushima N, Goggins MG, Kern SE, Maitra A. Homozygous deletion of the MTAP gene in
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invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy.
Cancer Biol Ther. 2005; 4:83-6.
94.
Hustinx SR, Leoni LM, Yeo CJ, Brown PN, Goggins MG, Kern SE, Hruban RH, Maitra A. Concordant loss
of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous
deletion in a non-invasive precursor lesion. Mod Pathol. 2005; 18:959-63.
95.
Nowak NJ, Gaile D, Conroy J, McQuaid D, Cowell J, Carter R, Goggins MG, Hruban RH, Maitra A.
Genome wide aberrations in pancreatic adenocarcinoma. Cancer Genet Cytogenet. 2005; 161:36-50.
96.
Cao D, Wilentz RE, Abbruzzese JL, Ho L, Maitra A. Aberrant expression of maspin in idiopathic
inflammatory bowel disease is associated with disease activity and neoplastic transformation. Int J
Gastrointest Cancer. 2005; 36:39-46.
97.
Maitra A, Arking DE, Shivapurkar N, Ikeda M, Statsny V, Kassaeui K, Sui G, Cutler D, Liu Y, Brimble S,
Noaksson K, Hyllner J, Schulz TC, Zeng X, Freed W, Crook J, Abraham S, Colman A, Sartipy P, Matsui S,
Carpenter M, Gazadar AF, Rao M, Chakravarti A. Genomic alterations in cultured human embryonic stem
cells. Nat Genet. 2005; 37:1099-103.
98.
Karikari C, Mullendore ME, Eshleman JR, Argani P, Leoni L, Chattopadhay S, Hidalgo M, Maitra A.
Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. Mol Cancer
Therap. 2005; 4:1860-6.
99.
Hansel DE, Maitra A, Lin J, Goggins MG, Argani P, Yeo CJ, Piantadosi S, Leach SD, Biankin AV.
Expression of caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the
ampulla of Vater. J Clin Oncol. 2005; 23:1811-8.
100. Jimeno A, Rubio B, Amador ML, Oppenheimer D, Bouraoud N, Kulesza P, Sebastini V, Maitra A, Hidalgo
M. Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor
targeted agents. Cancer Res. 2005; 65:3003-10.
101. Bashyam MD, Bair R, Kim YH, Wang P, Hernandez-Boussard T, Karikari CA, Tibshirani R, Maitra A,
Pollack JR. Array-based comparative genomic hybridization identifies localized DNA amplifications and
homozygous deletions in pancreatic cancer. Neoplasia. 2005; 7:556-62.
102. Hansel DE, Dhara S, Huang RC, Ashfaq R, Diesel M, Shimada Y, Bernstein H, Harmon J, Brock M,
Forastiere A, Washington MK, Maitra A, Montgomery E. CDC2/CDK1 expression in esophageal
adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential
novel drug target. Am J Surg Pathol. 2005; 29:390-9.
103. Cao D, Maitra A, Saavedra JA, Klimstra D, Adsay NV, Hruban RH. Expression of novel markers of
pancreatic ductal adenocarcinoma in pancreatic non-ductal neoplasms: additional evidence of different
genetic pathways. Mod Pathol. 2005; 18:752-61.
104. Prasad N, Biankin AV, Fukushima N, Maitra A, Dhara S, Elkahloun AG, Hruban RH, Goggins MG, Leach
SD. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling
on pancreatic ductal epithelial cells. Cancer Res. 2005; 65:1619-26.
105. Cunningham SC, Kamnagar F, Kim M, Hammoud S, Haque R, Maitra A, Montgomery EA, Heitmiller R,
Choti M, Lillemoe K, Cameron JL, Yeo CJ, Schulick RD. Survival after gastric adenocarcinoma resection:
eighteen-year experience at a single institution. J Gastrointest Surg. 2005; 9:718-25.
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106. Powell EL, Leoni LM, Canto MI, Forastiere AA, Iacobuzio-Donahue CA, Wang JS, Maitra A, Montgomery
E. Concordant Loss of MTAP and p16/CDKN2A Expression in Gastroesophageal Carcinogenesis: Evidence
of Homozygous Deletion in Esophageal Noninvasive Precursor Lesions and Therapeutic Implications. Am J
Surg Pathol. 2005; 29:1497-1504.
107. Hustinx SR, Fukushima N, Zahurak ML, Riall TS, Maitra A, Brosens L, Cameron JL, Yeo CJ, Offerhaus
GJ, Hruban RH, Goggins M. Expression and Prognostic Significance of 14-3-3sigma and ERM Family
Protein Expression in Periampullary Neoplasms. Cancer Biol Ther. 2005; 4:596-601.
108. Chen YC, Davidson B, Cheng CC, Maitra A, Giuntoli RL 2nd, Hruban RH, Wang TL, Shih IM.
Identification and characterization of membralin, a novel tumor associated gene, in ovarian carcinoma.
Biochim Biophys Acta. 2005; 1730:96-102.
109. Duxbury MS, Matros E, Clancy T, Bailey G, Doff M, Zinder MJ, Ashley SW, Maitra A, Redston M, Whang
EE. CEACAM6 is a novel biomarker in pancreatic adenocarcinoma and PanIN lesions. Ann Surg. 2005;
241:491-6.
110. Jakupciak JP, Wang W, Markowitz ME, Ally D, Coble M, Srivastava S, Maitra A, Barker PE, Sidransky D,
O’Connell CD. Mitochondrial DNA as a cancer biomarker. J Mol Diagn. 2005; 7:258-67.
111. Martin ST, Sato N, Dhara S, Chang R, Hustinx S, Abe T, Maitra A, Goggins. MG. Aberrant methylation of
the human hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. Cancer Biol Ther. 2005;
4:728-33.
112. Zhou S, Kassauei K, Cutler DJ, Kennedy G, Sidransky D, Maitra A*, Califano J*. An oligonucleotide
microarray for high-throughput sequencing of the mitochondrial genome. J Mol Diagn. 2006; 8:476-82
(*corresponding authors)
113. Sui G, Zhou S, Cutler DJ, Wang J, Canto M, Lee EE, Montgomery EA, Sidransky D, Califano J, Maitra A.
Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early
detection of cancer. Mol Cancer. 2006; 5:73.
114. Kassauei K, Habbe N, Mullendore ME, Karikari CA, Maitra A*, Feldmann G*. Mitochondrial DNA
mutations in pancreatic cancer. Int J Gastrointest Cancer. 2006; 37:57-64 (Joint corresponding authors)
115. Gronborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH,
Goggins MG, Maitra A, Pandey A. Biomarker discovery from pancreatic cancer secretome using a
differential proteomic approach. Mol Cell Proteomics. 2006; 5:157-71.
116. Plaia TW, Josephson R, Liu Y, Zeng X, Ording C, Toumadje A, Brimble SN, Sherrer ES, Uhl EW, Freed
WJ, Schultz TC, Maitra A, Rao MS, Auerbach JM. Characterization of a new NIH registered variant human
embryonic stem cell line BG01V: A tool for human embryonic stem cell research. Stem Cells. 2006; 24:53146.
117. House MG, Cameron JL, Lillemoe KD, Sculick RD, Choti MA, Hansel DE, Hruban RH, Maitra A, Yeo CJ.
Differences in survival for patients with resectable versus unresectable metastases from pancreatic islet cell
cancer. J Gastrointest Surg. 2006; 10:138-45.
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118. Tassi E, Henke RT, Bowden ET, Swift MR, Kodack DP, Maitra A, Wellstein A. Expression of a fibroblast
growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon. Cancer
Res. 2006; 66:1191-8.
119. Hruban RH, Adsay NV, Albores-Saavedra J, Anver MR, Biankin AV, Boivin GP, Furth EE, Furukawa T,
Klein A, Klimstra DS, Kloppel G, Lauwers GY, Longnecker DS, Luttges J, Maitra A, Offerhaus GJ, PerezGallego L, Redston M, Tuveson DA. Pathology of genetically engineered mouse models of pancreatic
exocrine cancer: consensus report and recommendations. Cancer Res. 2006; 66:95-106.
120. Montgomery E, Mamelak A, Gibson M, Maitra A, Sheikh S, Amr SS, Yang S, Brock M, Forastiere A,
Zhang S, Murphy KM, Berg KD. Overexpression of claudin proteins in esophageal adenocarcinoma and its
precursor lesions. Appl Immunohistochem Mol Morphol. 2006; 14:24-30.
121. Cunningham SC, Kamnagar F, Kim MP, Hammoud S, Haque R, Iacobuzio-Donahue C, Ashfaq R, Kern SE,
Maitra A, Yeo CJ, Schulick RD, Montgomery E. Claudin-4, mitogen-activated protein kinase kinase 4, and
stratifin are markers of gastric adenocarcinoma precursor lesions. Cancer Epidemiol Biomarkers Prev. 2006;
15:281-7.
122. Sui G, Bonde P, Dhara S, Broor A, Wang J, Marti G, Ferguson M, Duncan M, Montgomery E, Maitra A,
Harmon J. Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal
cancer cells from rat reflux model. J Surg Res. 2006; 134:1-9.
123. Rakheja D, Maitra A, Kapur P, Weinberg AG. Extrahepatic biliary atresia demonstrates abnormal
persistence of HES1 protein in neonatal biliary epithelium: an immunohistochemical study. Pediatr Dev
Pathol. 2006; 9:98-102.
124. Moff SL, Clark DP, Maitra A, Pandey A, Thuluvath PJ. Utility of bile duct brushings for the early detection
of cholangiocarcinoma in patients with primary sclerosing cholangitis. J Clin Gastroenterology. 2006;
40:336-41.
125. Hidalgo M., Amador ML., Jimeno A., Mezzadra H., Patel P., Chan A., Nielsen ME., Maitra A. Altiok S.
Assessment of Gefitinib and CI-1040-mediated changes in epidermal growth factor receptor signaling in
HuCCT-1 human cholangiocarcinoma by serial fine needle aspiration. Mol Cancer Ther. 2006; 5:1895-903.
126. Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, Karikari C, Shi C, Danenberg K,
Danenberg PV, Kuramochi H, Tanaka K, Singh S, Salimi-Moosavi H, Bouraoud N, Amador ML, Altiok S,
Kulesza P, Yeo CJ, Messrsmith W, Eshleman JR, Hruban RH, Maitra A, Hidalgo M. An in vivo platform for
translational drug development in pancreatic cancer. Clin Cancer Res. 2006; 12:4652-61.
127. Hansel DE, Meeker AK, Hicks J, De Marzo A, Lillemoe KD, Schulick R, Hruban RH, Maitra A, Argani P.
Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma. Mod Pathol. 2006; 19:772-9.
128. Tsuji K, Yang M, Jiang P, Maitra A, Kaushal S, Yamauchi K, Katz M, Moossa AR, Hoffman RM, Bouvet
M. Common bile duct injection as a novel method for establishing red fluorescent protein (RFP)-expressing
human pancreatic cancer in nude mice. JOP. 2006; 7:193-9.
129. Jiang P, Yamauchi K, Yang M, Tsuji K, Xu M, Maitra A, Bouvet M, Hoffman RM. Tumor cells genetically
labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle. 2006;
5:1198-201.
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130. Cao D, Antonescu C, Wong G, Winter J, Maitra A, Adsay V, Klimstra DS, Hruban RH. Positive
immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated
with KIT/PDGFRA mutations. Mod Pathol. 2006; 19:1157-63.
131. Bibikova M, Chudin E, Wu B, Zhou L, Wickham GE, Liu Y, Shin S, Plaia T, Auerbach J, Arking DE,
Gonzalez R, Crook J, Davidson B, Schulz T, Robins A, Khanna A, Sartipy P, Hyllner J, Vanguri P, SavantBhonsale S, Smith AK, Chakravarti A, Maitra A, Rao M, Barker DL, Loring JF, Fan JB. Human embryonic
stem cells have a unique epigenetic signature. Genome Res. 2006; 16:1075-83.
132. Calhoun E, Hucl T, Gallmeier E, West KM, Arking DE, Maitra A, Iacobuzio-Donahue C, Chakravarti A,
Hruban RH, Kern SE. Identifying allelic loss and homozygous deletions in pancreatic cancer without
matched normals using high-density single nucleotide polymorphism arrays. Cancer Res. 2006; 66:7920-8.
133. Josephson R, Sykes G, Liu Y, Ording C, Xu W, Zeng X, Shin S, Loring J, Maitra A, Rao MS, Auerbach J. A
molecular scheme for improved characterization of human embryonic stem cell lines. BMC Biol. 2006; 4:28.
134. Brune K, Abe T, Canto M, O’Malley L, Klein A, Maitra A, Adsay NV, Fishman E, Cameron JL, Yeo CJ,
Kern SE, Goggins MG, Hruban RH. Multifocal neoplastic precursor lesions associated with lobular atrophy
of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol. 2006;
30:1067-76.
135. Amoh Y, Nagakura C, Maitra A, Moossa AR, Katsuoka K, Hoffman R, Bouvet M. Dual-color imaging of
nascent angiogenesis and its inhibition in liver metastases of pancreatic cancer. Anticancer Res. 2006;
26:3237-42.
136. Cunningham SC, Kamnagar F, Kim MP, Hammoud S, Haque R, Iacobuzio-Donahue C, Ashfaq R, Kern R,
Maitra A, Heitmiller R, Choti M, Lillemoe KD, Cameron JL, Yeo CJ, Montgomery E, Schulick RD. MKK4
status predicts survival after resection of gastric adenocarcinoma. Arch Surg. 2006; 141:1095-9.
137. Jimeno A, Amador ML, Kulesza P, Wang X, Rubio-Viquera B, Zhang X, Chan A, Wheelhouse J, Kuramochi
H, Tanaka K, Danenberg K, Messersmith WA, Almuete V, Hruban RH, Maitra A, Yeo CJ, Hidalgo M.
Assessment of celecoxib pharmacodynamics in pancreatic cancer. Mol Cancer Ther. 2006; 5:3240-7.
138. Lam-Himlin DM, Daniels JA, Gayyed MF, Dong J, Maitra A, Pan D, Montgomery EA, Anders RA. The
hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway. Int J
Gastrointest Cancer. 2006; 37:103-9.
139. Karikari CA, Roy I, Tryggestad E, Feldmann G, Pinilla C, Reed J, Armour EP, Wong J, Herman J, Rakheja
D, Maitra A. Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of
the X-linked inhibitor of apoptosis protein. Mol Cancer Ther. 2007; 6:957-66.
140. Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty RM, Mullendore M, Karikari CA, Alvarez H, IacobuzioDonahue C, Jimeno A, Gabrielson KM, Matsui W, Maitra A. Blockade of Hedgehog signaling inhibits
pancreatic cancer invasion and metastasis – a new paradigm for combination therapy in solid cancers. Cancer
Res. 2007; 67:2187-96.
141. Bisht S, Feldmann G, Soni S, Ravi R, Karikari C, Maitra A, Maitra A. Polymeric nanoparticle encapsulated
curcumin (“nanocurcumin”): a novel strategy for human cancer therapy. J Nanobiotechnol. 2007; 5:3 (Highly
accessed article)
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142. Rubio-Viqueira B, Mezzadra H, Nielsen ME, Jimeno A, Zhang X, Iacobuzio-Donahue C, Maitra A, Hidalgo
M, Altiok S. Optimizing the development of targeted agents in pancreatic cancer: tumor fine-needle
aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays. Mol Cancer Ther. 2007;
6:515-23.
143. Bonde P, Sui G, Dhara S, Broor A, Kim IF, Wiley JE, Wang J, Marti G, Ferguson M, Duncan M, Jaffee EM,
Montgomery EA, Maitra A, Harmon JW. Cytogenetic characterization and gene expression profiling in the
rat reflux induced esophageal tumor model. J Thorac Cardiovasc Surg. 2007; 133:763-9.
144. Jimeno A, Rubio-Viquera B, Amador ML, Grunwald V, Maitra A, Iacobuzio-Donahue C, Hidalgo M. Dual
mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic
cancer. Mol Cancer Ther. 2007; 6:1079-88.
145. Cao D, Zhang Q, Wu LS, Salaria S, Winter J, Hruban RH, Goggins M, Abbruzzese JL, Maitra A, Ho L.
Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223
surgically resected cases. Mod Pathol. 2007; 20:570-8.
146. Salaria S, Illei P, Sharma R, Walter KM, Klein AP, Eshleman JR, Maitra A, Schulick R, Winter J, Ouellette
M, Goggins M, Hruban RH. Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal
adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells. Cancer Bio Ther.
2007; 6:324-8.
147. Zhou S, Kachhap S, Sun W, Wu G, Chuang A, Poeta L, Grumbine L, Mithani SK, Chatterjee A, Koch W,
Westra WH, Maitra A, Glazer C, Carducci M, Sidransky D, McFate T, Verma A, Califano J. Frequency and
phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and
neck. Proc Natl Acad Sci. 2007; 104; 7540-5.
148. Yong KT, Qian J, Roy I, Lee HH, Bergey EJ, Tramposch KM, He S, Swihart M, Maitra A, Prasad PN.
Quantum rod bio-conjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer
cells. Nano Lett. 2007; 7:761-5.
149. Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M,
Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT. Transactivation of miR-34a by p53
broadly influences gene expression and promotes apoptosis. Mol Cell. 2007; 26:745-52.
150. Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan D.
Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell. 2007; 130:1120-33.
151. Wu F, Dassopoulos T, Cope L, Maitra A, Brant SR, Harris ML, Bayless T, Parmiagani G, Chakravarti S.
Genome wide gene expression differences in Crohn’s and ulcerative colitis from endoscopic pinch biopsies:
insights into distinctive pathogenesis. Inflamm Bowel Dis. 2007; 13:807-21.
152. Foss CA, Fox JJ, Feldman G, Maitra A, Iacobuzio-Donahue C, Kern SE, Hruban RH, Pomper MG.
Radiolabeled anti-claudin 4 and anti-prostate stem cell antigen: initial imaging in experimental models of
pancreatic cancer. Mol Imaging. 2007; 6:131-9.
153. Mithani SK, Smith IM, Zhou S, Gray A, Koch WM, Maitra A, Califano JA. Mitochondrial resequencing
arrays detect tumor-specific mutations in salivary rinses of patients with head and neck cancer. Clin Cancer
Res. 2007; 13:7335-40.
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154. Daniels JA, Lederman HM, Maitra A, Montgomery EA. Gastrointestinal tract pathology in patients with
common variable immunodeficiency (CVID): a clinicopathologic study and review. Am J Surg Pathol. 2007;
31:1800-12.
155. Fendrich V, Waldmann J, Esni F, Ramaswamy A, Mullendore M, Buchholz M, Maitra A, Feldmann G.
Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum. Endocr Relat Cancer. 2007;
14:865-74.
156. Lucito R, Suresh S, Walter K, Pandey A, Lakshmi B, Krasnitz A, Sebat J, Wigler M, Klein AP, Brune K,
Palmisano E, Maitra A, Goggins M, Hruban RH. Copy-Number Variants in Patients with a Strong Family
History of Pancreatic Cancer. Cancer Biol Ther. 2007; 6:1592-9.
157. Lee KM, Cao D, Itami A, Pour PM, Hruban RH, Maitra A, Ouellette MM. Class III beta-tubulin, a marker of
resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia.
Histopathology. 2007; 51:539-46.
158. Qian J, Yong KT, Roy I, Ohulchanskyy TY, Bergey EJ, Lee HH, Tramposch KM, He S, Maitra A, Prasad
PN. Imaging pancreatic cancer using surface-functionalized quantum dots. J Phys Chem B. 2007; 111:696972.
159. Tan AC, Fan JB, Karikari C, Bibikova M, Garcia EW., Zhou L, Barker D, Serre D, Feldmann G, Hruban RH,
Klein AP, Goggins M, Couch FJ, Hudson TJ, Winslow RL, Maitra A*, Chakravarti A*. Allele-specific
expression in the germline of patients with familial pancreatic cancer: An unbiased approach to cancer gene
discovery. Cancer Biol Ther. 2008; 7:135-44 (Joint corresponding authors)
160. Feldmann G, Habbe N, Dhara S, Bisht S, Alvarez H, Fendrich V, Beaty R, Mullendore M, Karikari C,
Bardeesy N, Oullette MM, Yu W, Maitra A. Hedgehog inhibition prolongs survival in a genetically
engineered mouse model of pancreatic cancer. Gut. 2008; 57:1420-30.
161. Alvarez H, Corvalan A, Roa JC, Argani P, Murillo F, Edwards J, Beaty R, Feldmann G, Hong S-M,
Mullendore M, Roa I, Ibañez L, Pimente F, Diaz A, Riggins GJ, Maitra A. Serial analysis of gene expression
(SAGE) identifies connective tissue growth factor (CTGF) expression as a prognostic biomarker in
gallbladder cancer. Clin Cancer Res. 2008; 14:2631-8.
162. Fendrich V, Esni F, Garay MV, Feldmann G, Habbe N, Jensen JN, Dor Y, Stoffers D, Jensen J, Leach SD,
Maitra A. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology.
2008; 135:621-31.
163. Alvarez H, Leal Rojas P, Yong K-T, Ding H, Xu G, Prasad PN, Wang J, Canto M, Eshleman JR,
Montgomery EA, Maitra A. Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated
adenocarcinoma progression model: Translational implications for diagnosis and therapy. Nanomedicine.
2008; 4:295-301.
164. Zou G-M, Maitra A. Small molecule inhibitor of the APE1/REF-1 E3330 inhibits pancreatic cancer cell
growth and migration. Mol Cancer Ther. 2008; 7:2012-21.
165. Feldmann G, Fendrich V, McGovern K, Bedja D, Bisht S, Alvarez H, Koorstra JB, Habbe N, Karikari C,
Mullendore M, Gabrielson K, Sharma R, Matsui W, Maitra A. An orally bioavailable small molecule
inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer
Ther. 2008; 7:2725-35.
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166. Alvarez H, Koorstra JB, Hong SM, Boonstra JJ, Dinjens WN, Wu TT, Montgomery E, Eshleman JR, Maitra
A. Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line.
Cancer Biol Ther. 2008; 7:1753-55.
167. Cheung W, Darfler MM, Alvarez H, Hood BL, Conrads TP, Habbe N, Krizman DB, Mollenhauer J,
Feldmann G, Maitra A. Application of a global proteomic approach to archival precursor lesions: Deleted in
Malignant Brain Tumors 1 (DMBT1) and Tissue Transglutaminase-2 (TGM2) are upregulated in pancreatic
cancer precursors. Pancreatology. 2008; 6:608-16.
168. Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach
SD, Maitra A. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell
targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A. 2008; 105:18913-8.
169. Bisht S, Feldmann G, Koorstra JB, Mullendore M, Alvarez H, Karikari C, Rudek MA, Lee CK, Maitra Sr. A,
Maitra A. In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery
capabilities. Mol Cancer Ther. 2008; 7:3878-88.
170. Zou GM, Karikari C, Kabe Y, Handa H, Anders RA, Maitra A. The Ape-1/Ref-1 redox antagonist E3330
inhibits the growth of tumor endothelium and endothelial progenitor cells: Therapeutic implications in tumor
angiogenesis. J Cell Physiol. 2008; 219:209-218.
171. Karanjawala ZE, Illei PB, Ashfaq R, Infante JR, Murphy K, Pandey A, Schulick R, Winter J, Sharma R,
Maitra A, Goggins M, Hruban RH. New markers of pancreatic cancer identified through differential gene
expression analyses: claudin 18 and annexin A8. Am J Surg Pathol. 2008; 32:188-196.
172. Kumar R, Roy I, Ohulchanskyy TY, Goswami LN, Bonoiu AC, Bergey EJ, Tramposch KM, Maitra A,
Prasad PN. Covalently dye-linked, surface-controlled, and bioconjugated organically modified silica
nanoparticles as targeted probes for optical imaging. ACS Nano. 2008; 2:449-56.
173. Kumar SK, Roy I, Anchoori RK, Fazli S, Maitra A, Beachy PA, Khan SR. Targeted inhibition of hedgehog
signaling by cyclopamine prodrugs for advanced prostate cancer. Bioorg Med Chem. 2008; 16:2764-8.
174. Kwei KA, Bashyam MD, Kao J, Ratheesh R, Reddy EC, Kim YH, Montgomery K, Giacomini CP, Choi Y-L,
Chatterjee S, Karikari CA, Salari K, Wang P, Hernandez-Boussard T, Swarnalata G, van de Rijn M, Maitra
A, Pollack JR. Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary
cancer. PLoS Genetics. 2008; 4:e1000081.
175. Jimeno A, Tan AC, Coffa J, Rajeshkumar NV, Kulesza P, Rubio-Viqueira B, Wheelhouse J, Diosdado B,
Messersmith WA, Iacobuzio-Donahue C, Maitra A, Varella-Garcia M, Hirsch FR, Meijer GA, Hidalgo M.
Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor
receptor inhibitor sensitivity in pancreatic cancer. Cancer Res. 2008; 68:2841-9.
176. An W, Han JS, Schrum CM, Maitra. A, Koentgen F, Boeke JD. Conditional activation of a single-copy L1
transgene in mice by Cre. Genesis. 2008; 46:373-383.
177. Park SW, Davison JM, Rhee J, Hruban RH, Maitra A, Leach SD. (Cover Article) Oncogenic KRAS induces
progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology.
2008; 134:2080-90.
178. Steinhardt AA, Gayyed MF, Klein AP, Dong J, Maitra A, Pan D, Montgomery EA, Anders RA. Expression
of Yes-associated protein in common solid tumors. Hum Pathol. 2008; 3:1582-9.
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179. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno
A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J,
Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C,
Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu
VE, Kinzler KW. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Science. 2008; 321:1801-6.
180. Harsha HC, Jimeno A, Molina H, Mihalas AB, Goggins MG, Hruban RH, Schulick RD, Kamath U, Maitra
A, Hidalgo M, Pandey A. Activated Epidermal Growth Factor Receptor as a Novel Target in Pancreatic
Cancer Therapy. J Proteome Res. 2008; 7:4651–8.
181. Jakupciak JP, Maragh S, Markowitz ME, Greenberg AK, Hoque MO, Maitra A, Barker PE, Wagner PD,
Rom WN, Srivastava S, Sidransky D, O'Connell CD. Performance of mitochondrial DNA mutations
detecting early stage cancer. BMC Cancer. 2008; 8:285.
182. Chen S, Auletta T, Dovirak O, Hutter C, Kuntz K, El-Ftesi S, Kendall J, Han H, Von Hoff DD, Ashfaq R,
Maitra A, Iacobuzio-Donahue CA, Hruban RH, Lucito R. Copy number alterations in pancreatic cancer
identify recurrent PAK4 amplification. Cancer Biol Ther. 2008; 7:1793-1802.
183. Kristiansen TZ, Harsha HC, Grønborg M, Maitra A, Pandey A. Differential Membrane Proteomics Using
(18O-Labeling To Identify Biomarkers for Cholangiocarcinoma. J Proteome Res. 2008; 7:4670–7.
184. Habbe N, Koorstra JBM, Mendell JT, Offerhaus GJ, Ryu JK, Feldmann G, Mullendore ME, Goggins MG,
Hong S-M, Maitra A. MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. Cancer Biol Ther.
2009; 8:340-6.
185. Mullendore ME, Koorstra JB, Li Y-M, Offerhaus GJ, Fan X, Henderson CM, Matsui W, Eberhart CG,
Maitra A, Feldmann G. Ligand-dependent Notch signaling is involved in tumor initiation and tumor
maintenance in pancreatic cancer. Clin Cancer Res. 2009; 15:2291-301.
186. Koorstra JB, Collins CA, Feldmann G, Bisht S, Leal Rojas P, Offerhaus GJA, Alvarez H, Maitra A. The Axl
tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic
target. Cancer Biol Ther. 2009; 8:618-26.
187. Hristov AC, Cope L, Reyes MD, Singh M, Iacobuzio-Donahue C, Maitra A, Resar LM. HMGA2 protein
expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal
adenocarcinoma. Mod Pathol. 2009; 22:43–9.
188. Jimeno A, Feldmann G, Suárez-Gauthier A, Rasheed Z, Solomon A, Zou GM, Rubio-Viqueira B, GarcíaGarcía E, López-Ríos F, Matsui W, Maitra A, Hidalgo M. A direct pancreatic cancer xenograft model as a
platform for cancer stem cell therapeutic development. Mol Cancer Ther. 2009; 8:310-4.
189. Yong KT, Ding H, Roy I, Law WC, Bergey EJ, Maitra A, Prasad PN. Imaging Pancreatic Cancer Using
Bioconjugated InP Quantum Dots. ACS Nano. 2009; 3:502–10.
190. Blackford A, Parmigiani G, Kensler T, Wolfgang C, Jones S, Zhang X, Parsons D, Lin J, Leary R, Eshleman
J, Goggins M, Jaffee E, Iacobuzio-Donahue C, Maitra A, Klein A, Cameron J, Olino K, Schulick R, Winter
J, Vogelstein B, Velculescu V, Kinzler K. Genetic Mutations Associated With Cigarette Smoking in
Pancreatic Cancer. Cancer Res. 2009; 69:3681-8.
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191. Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, Lin JC-H, Palmisano E, Brune K,
Jaffee E, Iacobuzio-Donahue CA, Maitra A, Parmigiani G, Kern SE, Velculescu VE, Kinzler KW,
Vogelstein B, Eshleman JR, Goggins M, Klein AP. Exomic Sequencing Identifies PALB2 as a Pancreatic
Cancer Susceptibility Gene. Science. 2009; 324:217.
192. Lee KH, Lotterman C, Karikari C, Omura N, Feldmann G, Habbe N, Goggins MG, Mendell JT, Maitra A.
Epigenetic Silencing of MicroRNA miR-107 Regulates Cyclin-dependent Kinase 6 (CDK6) Expression in
Pancreatic Cancer. Pancreatology. 2009; 9:293-301.
193. Yong K-T; Hu R; Roy I; Ding H; Vathy L; Bergey E; Mizuma M; Maitra A; Prasad P. Tumor Targeting and
Imaging in Live Animals with Functionalized Semiconductor Quantum Rods. ACS Applied Mater Interfaces.
2009; 1:710-19.
194. Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ,
Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R,
Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, Kinzler KW, Velculescu VE, Hruban RH. SMAD4
gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res 2009; 15:4674-9
195. Wu JM, Alvarez H, García P, Rojas PL, Wong G, Maitra A, Antonescu C, Montgomery EA. Melanoma
Hyperpigmentation Is Strongly Associated With KIT Alterations. Am J Dermatopathol. 2009; 31:619-25.
196. Shi C, Chandrasekaran A, Thuluvath PJ, Karikari C, Argani P, Goggins M, Maitra A, Eshleman JR.
Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma
using LigAmp technology. J Mol Diagn. 2009; 11:583-9.
197. Fendrich V, Chen NM, Neef M, Waldmann J, Bucholz M, Feldmann G, Slater EP, Maitra A, Bartsch DK.
The Angiotensin-I-converting Enzyme Inhibitor Enalapril and Aspirin delay progression of Pancreatic
Intraepithelial Neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.
Gut 2010 May; 59(5):630-7. (doi: 10.1136/gut.2009.188961).
198. Kent OA, Mullendore ME, Wentzel EA, López-Romero P, Tan AC, Alvarez H, West K, Ochs MF, Hidalgo
M, Arking DE, Maitra A, Mendell JT. A resource for analysis of microRNA expression and function in
pancreatic ductal adenocarcinoma cells. Cancer Biol Ther. 2009; 8:2013-24.
199. Koorstra JB, Hong SM, Shi C, Meeker AK, Ryu JK, Offerhaus GJ, Goggins MG, Hruban RH, Maitra A.
Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod
Pathol 2009; 22:1439-45.
200. Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, Schulick R, Palmisano E, Hruban RH. Increased
Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin Cancer Res. 2009; 15:7737-43.
201. Hristov AC, Cope L, Di Cello F, Reyes MD, Singh M, Hillion JA, Belton A, Joseph B, Schuldenfrei A,
Iacobuzio-Donahue CA, Maitra A, Resar LM. HMGA1 correlates with advanced tumor grade and decreased
survival in pancreatic ductal adenocarcinoma. Mod Pathol. 2010; 23:98-104
202. Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL,
Dang CV. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.
Proc Natl Acad Sci U S A. 2010; 107:2037-42.
203. Rasheed ZA, Yang J, Wang Q, Kowalski J, Freed I, Murter C, Hong SM, Koorstra JB, Rajeshkumar NV, He
X, Goggins M, Iacobuzio-Donahue C, Berman DM, Laheru D, Jimeno A, Hidalgo M, Maitra A, Matsui W.
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Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. J Natl
Cancer Inst. 2010; 102(5):340-51
204. Ryu JK, Hong S-M, Karikari CA, Hruban RH, Goggins MG, Maitra A. Aberrant MicroRNA-155 Expression
Is an Early Event in the Multistep Progression of Pancreatic Adenocarcinoma. Pancreatology. 2010; 10:6673.
205. Kamiyama H, Kamiyama M, Hong SM, Karikari CA, Lin MT, Borges MW, Griffith M, Young A,
Norris-Kirby A, Lubek C, Mizuma M, Feldmann G, Shi C, Liang H, Goggins MG, Maitra A,
Hruban RH, Eshleman JR. In vivo and in vitro propagation of intraductal papillary mucinous
neoplasms. Lab Invest. 2010 May; 90(5):665-73 [doi: 10.1038/labinvest.2010.51].
206. Feldmann G, Mishra A, Hong S-M, Bisht S, Strock CJ, Ball DW, Goggins G, Maitra A*, Nelkin
BD* (*joint corresponding authors). Inhibiting the cyclin-dependent kinase CDK5 blocks
pancreatic cancer formation and progression via suppression of Ras-Ral signaling. Cancer Res.
2010 Jun 1; 70(11):4460-9. (Cover article).
207. Bisht S, Mizuma M, Feldmann G, Ottenhof N, Hong S-M, Pramanik D, Chenna V, Karikari C,
Sharma R, Goggins MG, Rudek MA, Ravi R, Maitra A, Maitra A. Systemic administration of
polymeric nanoparticle-encapsulated curcumin (NanoCureTM) blocks tumor growth and metastases
in preclinical models of pancreatic cancer. Mol Cancer Ther. 2010 Aug; 9(8):2255-64.
208. Shi C, Siegelman SS, Kawamoto S, Wolfgang CL, Schulick RD, Maitra A, Hruban RH. Pancreatic
Duct Stenosis Secondary to Small Endocrine Neoplasms: A Manifestation of Serotonin
Production? Radiology. 2010 Oct; 257(1):107-14. (doi: 10.1148/radiol.10100046).
209. Ishizawa K, Rasheed ZA, Karisch R, Wang Q, Kowalski J, Susky E, Pereira K, Karamboulas C,
Moghal N, Rajeshkumar NV, Hidalgo M, Tsao M, Ailles L, Waddell TK, Maitra A, Neel BG,
Matsui W. Tumor-Initiating Cells Are Rare in Many Human Tumors. Cell Stem Cell. 2010;
7(3):279-82.
210. Alvarez H, Montgomery EA, Karikari C, Canto M, Dunbar KB, Wang JS, Feldmann G, Hong SM,
Haffner MC, Meeker AK, Holland SJ, Yu J, Heckrodt TJ, Zhang J, Ding P, Goff D, Singh R, Roa
JC, Marimuthu A, Riggins GJ, Eshleman JR, Nelkin BD, Pandey A, Maitra A. The Axl receptor
tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal
adenocarcinoma. Cancer Biol Ther. 2010 Nov 4;10(10). [Epub ahead of print].
211. Ray B, Bisht S, Maitra A, Maitra A, Lahiri, DK. Neuroprotective and Neurorescue Effects of a
Novel Polymeric Nanoparticle Formulation of Curcumin (NanoCurc™) in the Neuronal Cell
Culture and Animal Model: Implications for Alzheimer’s disease. J Alzheimers Disease. 2010, In
press.
212. Cai J, Zhang N, Zheng Y, de Wilde R, Maitra A, Pan D. The Hippo signaling pathway restricts the
oncogenic potential of an intestinal regeneration program. Genes Dev 2010 Nov 1; 24(21):2383-8.
213. Liby KT, Royce DB, Risingsong R, Williams CR, Maitra A, Hruban RH, Sporn MB. Synthetic
Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer. Cancer Prev
Res. 2010 Nov;3(11):1427-34.
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214. Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD,
Maitra A, Mendell JT. Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumorpromoting feed-forward pathway. Genes Dev. 2010 Dec 15; 24(24):2754-9.
215. Park JY, Hong S-M, Klimstra DS, Goggins MG, Maitra A, Hruban RH. Pdx1 Expression in
Pancreatic Precursor Lesions and Neoplasms. Applied Immunohistochemistry & Molecular
Morphology, 2011. In Press.
216. Alvarez H, Opalinska J, Zhou L, Sohal D, Fazzari MJ, Yu Y, Montagna C, Montgomery EA, Canto
M, Dunbar KB, Wang J, Roa JC, Mo Y, Bhagat T, Ramesh KH, Cannizzaro L, Mollenhauer J,
Thompson RF, Suzuki M, Meltzer S, Melnick A, Greally JM, Maitra A, Verma A (Joint
corresponding author). Widespread hypomethylation occurs early and synergizes with gene
amplification during esophageal carcinogenesis. Plos Genetics 2010 In Press.
217. Lim KJ, Bisht S, Bar EE, Maitra A, Eberhart CG. A polymeric nanoparticle formulation of
curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer
Biol Ther. 2011 11(5). [Epub ahead of print].
218. Villarroel MC, Kumar NV R, Garrido-Laguna I, De Jesus-Acosta A, Jones S, Maitra A, Hruban
RH, Eshleman JR, Klein AP, Laheru D, Donehower RC, Hidalgo M. Personalizing cancer
treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA
damaging agents in pancreatic cancer Mol Cancer Ther Epub 2010 Dec 6; doi:10.1158/15357163.MCT-10-0893.
Invited Reviews
1.
Wistuba II, Maitra A, Albores-Saavedra J, Gazdar AF. Molecular changes in cervical endocrine tumors.
Contemp Obstet Gynecol. 2000; 45:25-36.
2.
Maitra A, Wistuba II, Gazdar AF. Microdissection and the study of cancer pathways. Current Molecular
Medicine. 2001; 1:153-62.
3.
Takaori K, Hruban RH, Maitra A, Tanigawa N. Pancreatic Intraepithelial Neoplasia. Pancreas. 2004;
28:257-62.
4.
Henke R, Maitra A, Paik S, Wellstein A. Gene expression analysis in sections and tissue microarrays of
archival tissues by mRNA in situ hybridization. Histol Histopathol. 2005; 20:225-37.
5.
Hruban RH, Wilentz RE, Maitra A. Identification and analysis of precursors to invasive pancreatic cancer.
Methods Mol Med. 2005; 103:1-13.
6.
Hansel DE, Maitra A, Argani P. Pathology of the gallbladder: a concise review. Current Diag Pathol. 2005.
7.
Maitra A, Fukushima N, Takaori K, Hruban RH. Precursors to invasive pancreatic cancer. Adv Anat Pathol.
2005; 12:81-91.
8.
Henke RT, Kim SE, Maitra A, Park S, Wellstein A. Expression analysis of mRNA in formalin-fixed,
paraffin-embedded archival tissues by mRNA in situ hybdridization. Methods. 2006; 38:253-62.
9.
Takaori K, Hruban RH, Maitra A, Tanigawa N. Current topics on precursors to pancreatic cancer. Adv Med
Sci. 2006; 51:23-30.
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Maitra, Anirban
10.
Winter JM, Maitra A, Yeo CJ. Genetics and pathology of pancreatic cancer. HPB (Oxford). 2006; 8(5):32436.
11.
Singh M, Maitra A. Precursor lesions of pancreatic cancer: molecular pathology and clinical implications.
Pancreatology. 2007; 7:9-19.
12.
Feldmann G, Beaty RM, Hruban RH, Maitra A. Molecular genetics of pancreatic intraepithelial neoplasia. J
Hepatobiliary Pancreat Surg. 2007; 14:224-32.
13.
Beaty RM, Gronborg M, Pollack JR, Maitra A. Target discovery and validation in pancreatic cancer.
Methods Mol Biol. 2007; 360:57-89.
14.
Maitra A, Hruban RH. Pancreatic Cancer. Annu Rev Pathol Mech Dis. 2008; 3:157-88.
15.
Feldmann G, Maitra A. Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for
translational efforts. J Mol Diagn. 2008; 10(2):111-22 (Cover article)
16.
Koorstra JB, Feldmann G, Habbe N, Maitra A. Morphogenesis of pancreatic cancer: role of pancreatic
intraepithelial neoplasia (PanINs). Langenbecks Arch Surg. 2008; 393:561-70.
17.
Koorstra JB, Hustinx SR, Offerhaus GJ, Maitra A. Pancreatic Carcinogenesis. Pancreatology. 2008; 8:11025.
18.
Anders RA, Montgomery E, Maitra A. Johns Hopkins course: 8th annual Current Topics in Gastrointestinal
and Liver Pathology. Expert Rev Gastroenterol Hepatol. 2009; 3: 33-7.
19.
Ottenhof NA, Milne AN, Morsink FH, Drillenburg P, TenKate FJ, Maitra A, Offerhaus GJ. Pancreatic
intraepithelial neoplasia and pancreatic tumorigenesis: of mice and men. Arch Pathol Lab Med. 2009;
133:375-81
20.
Bisht S, Maitra A. Systemic delivery of curcumin: 21st cebtury solutions for an ancient
conundrum. Curr Drug Discov Technol. 2009; 6:192-9.
217. Bisht S, Brossart P, Maitra A, Feldmann G. Agents targeting the Hedgehog pathway for pancreatic cancer
treatment. Curr Opin Investig Drugs 2010 Dec;11(12):1387-98.
Invited Editorials
1.
Maitra A, Thuluvath PJ. GP73: A (Golgi) Complex Phenomenon. Am J Gastroenterol. 2004; 99:1096-8.
2.
Maitra A, Hruban RH. A new mouse model of pancreatic cancer: PTEN gets its Akt together. Cancer Cell.
2005; 8:171-2.
3.
Turner JR, Maitra A, Natkunam Y, Rubin BP, Rubin MA, Teitell MA. Bringing pathobiology into focus.
Lab Invest. 2006; 86:632.
4.
Hidalgo M, Maitra A. The Hedgehog pathway and pancreatic cancer. New Engl J Med. 2009; 361:2094-6.
5.
Maitra A. Tracking down the hedgehog's lair in the pancreas. Gastroenterology. 2010; 138:823-5.
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Maitra, Anirban
Scientific Abstracts
1.
Maitra A, Yashima K, Timmons CF, Shay JW, Gazdar AF. Expression of the RNA component of human
telomerase in neuroblastic tumors in children (Texas Society of Pathologists Residents' Seminar, Corpus
Christi, 1997)
2.
Maitra A, Hirany S, Jialal I. Comparison of two methods for measuring LDL cholesterol (Texas Society of
Pathologists Residents' Seminar, Corpus Christi, 1997)
3.
Timmons CF, Yashima K, Maitra A, Shay JW, Gazdar AF. Expression of the RNA component of telomerase
in Wilms tumors and nephrogenic rests (Society for Pediatric Pathology, 1997)
4.
Yashima K, Milchgrub S, Ashfaq R, Maitra A, Shay JW, Gazdar AF. High expression of human telomerase
RNA during multistage carcinogenesis may predict for imminent invasion (88 th American Association of
Cancer Research Annual Meeting, San Diego, 1997)
5.
Maitra A, Yashima K, Timmons CF, Shay JW, Gazdar AF. Expression of the RNA component of telomerase
in neuroblastic and non-Wilms' renal tumors in children (Society for Pediatric Pathology Meeting,
Minneapolis, 1997)
6.
Salahuddin S, Maitra A, Timmons CF, Gazdar AF. Allelotyping nephrogenic rests, the putative precursor
lesions of Wilms tumors (Society for Pediatric Pathology Meeting, Toronto, 1998)
7.
Maitra A, Ashfaq R, Saboorian MH, Gokaslan ST. Cytohistologic correlation in the primary diagnosis of
mesenchymal lesions - the role of FNAB in guiding management (46th American Society of Cytopathology
Annual Meeting, Nashville, 1998)
8.
Maitra A, Saboorian MH, Gokaslan ST, Lindberg G, Ashfaq R. Cytohistologic correlation of fine needle
aspiration biopsy of salivary gland lesions: a five year experience (88 th United States and Canadian Academy
of Pathology Meeting, San Francisco, 1999)
9.
Maitra A, Wistuba II, Virmani AK, Sakaguchi M, Park I, Minna JD, Gazdar AF. Enrichment of epithelial
cells for molecular studies (90th American Association of Cancer Research, Philadelphia, 1999).
10.
Park I, Wistuba II, Maitra A, Milchgrub S, Virmani AK, Gazdar AF. Multiple clonal abnormalities in
bronchial epithelium of lung cancer patients (90th American Association of Cancer Research, Philadelphia,
1999).
11.
Shivapurkar N, Sood S, Wistuba II, Virmani AK, Maitra A, Milchgrub S, Minna JD, Gazdar AF. Multiple
regions of chromosome 4 affected by loss of heterozygosity in breast carcinomas (90 th American Association
of Cancer Research Meeting, Philadelphia, 1999)
12.
Maitra A, Rathi A, Sagalowsky A, Gazdar AF, Ashfaq R. Expression of the RNA Component of Human
Telomerase (hTR) in Cytospin Preparations from Bladder Washings : A Correlative Study with Histology
(47th American Society of Cytopathology Annual Meeting, Sacramento, 1999)
13.
Lin WM, Ashfaq R, Michalopoulos E, Maitra A, Gazdar AF, Muller C. The utility of residual fluid based
cervical cytology for comprehensive molecular analyses (AACR Special Symposium on Biology and
Genetics of Early Detection and Chemoprevention of Cancer, Bar Harbour, 1999)
21
Maitra, Anirban
14.
Shivapurkar N, Maitra A, Milchgrub S, Gazdar AF. Deletions of chromosome 4 occur early during the
pathogenesis of colon cancer (91st American Association of Cancer Research Meeting, San Francisco, 2000).
15.
Maitra A, Gazdar AF, Wistuba II, Ashfaq R. Correlation of FHIT protein expression with loss of
heterozygosity in breast cancer cell lines (89th United States and Canadian Academy of Pathology Meeting,
New Orleans, 2000)
16.
Washington C, Wistuba I, Stuckey A, Maitra A, Mele G, Gazdar AF, Minna JD. Microdissected breast
cancers demonstrate a high frequency of 3p allele loss identifying at least 5 different putative tumor
suppresor gene sites (91st American Association of Cancer Research Meeting, San Francisco, 2000).
17.
Xu XL, Wu L, Maitra A, Tomlinson GE, Gazdar AF, Bowcock AM, Baer R, Minna JD. BE2, a BRCA1interacting protein located at the tumor suppressor locus 11p15.5-p15.4 undergoes epigenetic inactivation in
breast and lung cancer (Cold Spring Harbor Symposium, 2000).
18.
Maitra A, Wanzer D, Weinberg AG, Ashfaq R. Amplification of the Her-2/neu oncogene is uncommon in
pediatric osteosarcomas (Society for Pediatric Pathology Meeting Atlanta, 2001)
19.
Maitra A, Roberts H, Weinberg AG, Geradts J. Aberrant expression of cell cycle proteins in the Ewing
family of tumors (Society for Pediatric Pathology Meeting Atlanta, 2001)
20.
Maitra A, Roberts H, Weinberg AG, Geradts J. Aberrant expression of cell cycle proteins in the pediatric
osteosarcomas (Society for Pediatric Pathology Meeting Atlanta, 2001)
21.
Maitra A, Weinberg AG. Cell cycle abnormalities in juvenile polyps (Society for Pediatric Pathology
Meeting Atlanta, 2001)
22.
Maitra A, Chen TT, Savla J, Timmons CF, Wyatt-Ashmead J, Tomlinson GE. Mutations of the hSNF5/INI1
gene in choroid plexus carcinomas (Society for Pediatric Pathology Meeting Atlanta, 2001)
23.
Wistuba II, Ashfaq R, Maitra A, Pimentel F, Troncoso P, Alvarez H, Gazdar A, Minna JD. Chromosome 3p
and fhit gene abnormalities in the pathogenesis of gallbladder carcinoma (90th United States and Canadian
Academy of Pathology Meeting, Atlanta, 2001)
24.
Maitra A, Tascilar M, Hruban RH, Offerhaus GJ, Albores-Saavedra J. Small cell carcinoma of the
gallbladder: a clinicopathologic, immunohistochemical and molecular pathology study of twelve cases (90 th
United States and Canadian Academy of Pathology Meeting, Atlanta, 2001)
25.
Maitra A, Winick N, Schneider NR, Kroft SH, McKenna RW. Acute lymphoblastic leukemia t(1;19)
revisited. (90th United States and Canadian Academy of Pathology Meeting, Atlanta, 2001)
26.
ChenTT-L, Maitra A, Savla J, Wyatt-Ashmead J, Tomlinson GE. Mutational analysis of the hSNF5/INI1
gene in choroid plexus carcinomas and rhabdoid tumors (92nd American Association of Cancer Research
Meeting, New Orleans, 2001)
27.
Wistuba II, Tang M, Maitra A, Alvarez H, Troncoso P, Pimentel F, Minna J, Gazdar AF. Genome-Wide
Allelotyping Analysis Reveals Multiple Sites of Allelic Loss in Gallbladder Carcinoma (92 nd American
Association of Cancer Research Meeting, New Orleans, 2001)
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Maitra, Anirban
28.
Wistuba I, Maitra A, Carrasco R, Tang M, Troncoso T, Alvarez H, Gazdar A, Minna J. Chromosome 3p, 8p,
9q and 22q deletions in the sequential pathogenesis of gallbladder carcinoma (91st United States and
Canadian Academy of Pathology Meeting, Chicago, 2002)
29.
Harada K, Maitra A, Toyooka S, Mastrangelo D, Timmons CF, Tomlinson GE, Gazdar AF. Promoter
methylation of caspase-8 and rassf1a is a common event in solid tumors of childhood. (Society for Pediatric
Pathology Meeting, Chicago, 2002)
30.
Maitra A, Wistuba II, Miquel JF, Hruban RH, Argani P, Ashfaq R. Immunohistochemical analysis of
cyclooxygenase enzymes in the sequential pathogenesis of gallbladder carcinoma. (91st United States and
Canadian Academy of Pathology Meeting, Chicago, 2002)
31.
Iacobuzio-Donahue CA, Maitra A, Shen G, Berg K, Walters K, Kern SE, Goggins M, Hruban RH.
Discovery of novel tumor markers of pancreatic cancer using global gene expression technology (91st United
States and Canadian Academy of Pathology Meeting, Chicago, 2002)
32.
Wilentz RE, Ashfaq R, Maitra A, Dassopoulos T, Bayless TM, Talamini MA, et al. Immunohistochemical
expression of adenomatous polyposis coli (apc), beta-catenin, and E-cadherin in colitis-associated
adenocarcinomas and dysplasias (91st United States and Canadian Academy of Pathology Meeting, Chicago,
2002)
33.
Maitra A, Iacobuzio-Donahue CA, Agrani P, Wilentz RE, Cameron JL, Yeo CJ, et al. Expression of
mesothelin and prostate stem cell antigen – two novel markers identified by serial analysis of gene expression
– in mucinous cystic neoplasms and intraductal papillary mucinous neoplasms of the pancreas. (91st United
States and Canadian Academy of Pathology Meeting, Chicago, 2002)
34.
Iacobuzio-Donahue CA, Brown PO, Olsen M, Maitra A, Walters K, Jaffe E, et al. Exploration of global gene
expression of pancreatic cancer by cDNA microarray analysis (91st United States and Canadian Academy of
Pathology Meeting, Chicago, 2002)
35.
Maitra A, Ashfaq R, Hruban RH, Wilentz RE. Cyclooxygenase-2 expression in pancreatic adenocarcinomas
and pancreatic intraepithelial neoplasia (PanIN) (91st United States and Canadian Academy of Pathology
Meeting, Chicago, 2002)
36.
Maitra A, Timmons CF, Ilaria R, Wanzer D, Ashfaq R. Amplification of the Her-2/neu oncogene is
uncommon in Ewing fmily of tumors (Society for Pediatric Pathology Meeting, Chicago, 2002)
37.
Torbenson M, Choti M, Ashfaq R, Maitra A, Boitnott J B, Wilentz R. DPC4 over-expression in
hepatocellular carcinoma is strongly associated with TGF-Beta-Receptor II Immunolabeling (91st United
States and Canadian Academy of Pathology Meeting, Chicago, 2002)
38.
McCarthy DM, Maitra A, Rader AE, Faigel DO, Hruban RH, Wilentz RE. Utility of Novel Markers of
Pancreatic Duct Adenocarcinoma in Fine-Needle Aspiration: Mesothelin and Prostate Stem Cell Antigen
Increase Specificity. (91st United States and Canadian Academy of Pathology Meeting, Chicago, 2002)
39.
House MG, Guo MZ, Schulick RD, Cameron JL, Yeo CJ, Hruban RH, Groth J, Herman JG, Maitra A,
Geradts J. Abnormal Expression of Cell Cycle Control Genes in Pancreatic Endocrine Neoplasms. (92nd
United States and Canadian Academy of Pathology Meeting, Washington, DC, 2003)
40.
Hansel DE, Rahman A, Hruban RH, Shulick R, Thuluvath P, Ku J-L, Park J-G, Geradts J, Miyazaki K,
Ashfaq R, Hidalgo M, Argani P, Maitra A. Identification of Novel Targets in Biliary Tract Cancers Using
23
Maitra, Anirban
Global Gene Expression Technology (92nd United States and Canadian Academy of Pathology Meeting,
Washington, DC, 2003)
41.
Hansel DE, Meeker AK, Lillemoe KD, Shulick R, Hruban RH, Maitra A, Argani P. Telomere Length
Variation in Biliary Tract Metaplasia, Dysplasia and Carcinoma (92nd United States and Canadian Academy
of Pathology Meeting, Washington, DC, 2003)
42.
Iacobuzio-Donahue CA, Meeker AK, Maitra A, Wilentz RE, Kern SE, Montgomery EA, De Marzo A. Loss
of Telomere Maintainence Is an Early Event in Inflammatory Bowel Disease Related Neoplasia (92nd United
States and Canadian Academy of Pathology Meeting, Washington, DC, 2003)
43.
Maitra A, Van Heek T, Adsay V, Iacobuzio-Donahue C, Rahman A, Goggins MG, Wilentz RE, Argani P,
Hruban RH, Berg KD. Global Expression Analysis of Pancreatic and Colorectal Cancers Reveals CancerType Specific Tumor Markers (92nd United States and Canadian Academy of Pathology Meeting,
Washington, DC, 2003)
44.
Zhang H, Maitra A, Tabaczka P, Wilentz RE, Hruban RH, Adsay NV. Differential MUC1, MUC2 and
MUC5AC Expression in Colorectal, Ampullary and Pancreatobiliary Carcinomas: Potential Biologic and
Diagnostic Implications (92nd United States and Canadian Academy of Pathology Meeting, Washington, DC,
2003)
45.
Cheng C-C, Chen Y-C, Maitra A, Hruban RH, Gabrielson E, Kurman RJ, Shih I-M. Apolipoprotein E
Expression in Ovarian Serous Carcinoma and Other Types of Cancer (92nd United States and Canadian
Academy of Pathology Meeting, Washington, DC, 2003)
46.
Hansel DE, Rahman A, Hermans J, de Krijger R, Ashfaq R, Yeo C, Cameron J, Hruban RH, Maitra A.
Microvascular Density in Pancreatic Endocrine Neoplasms Is Associated with VEGF-C and VEGFR-2
Expression (92nd United States and Canadian Academy of Pathology Meeting, Washington, DC, 2003)
47.
Iacobuzio-Donahue CA, Swierczynski S, Maitra A, Hruban RH. Progressive Loss of Mesothelin Protein
Expression with Advanced Metastatic Disease in Patients with Pancreatic Ductal Adenocarcinoma (92nd
United States and Canadian Academy of Pathology Meeting, Washington, DC, 2003)
48.
Iacobuzio-Donahue CA, Maitra A, Berg K, Hollingsworth MA, Kern SE, Goggins MG, Hruban RH.
Exploration of Highly Expressed Genes in Pancreatic Duct Adenocarcinomas Using U133 Oligonucleotide
Arrays with Comparisons to Other Global Gene Expression Platforms (92nd United States and Canadian
Academy of Pathology Meeting, Washington, DC, 2003)
49.
Maitra A, Hansel DE, Rahman A, Geradts J, Yeo CJ, House MG, Argani P, Hruban RH. Global Expression
Analysis of Pancreatic Endocrine Neoplasms Using Oligonucleotide Microarrays (92nd United States and
Canadian Academy of Pathology Meeting, Washington, DC, 2003)
50.
Rahman A, Houlihan PS, Iacobuzio-Donahue CA, Klimstra DS, Zee S, Maitra A, Torbenson M, Hruban RH,
Abraham SC, Wu TT, Wilentz RE. Microsatellite Instability Occurs in a Subset of Pancreatic Intraductal
Papillary Mucinous Neoplasms (92nd United States and Canadian Academy of Pathology Meeting,
Washington, DC, 2003)
51.
Rahman A, Maitra A, Yeo CJ, Cameron JL, Hruban RH, Ashfaq R, Hansel DE. p27Kip1 Expression in
Metastatic and Non-Metastatic Pancreatic Endocrine Neoplasms (92nd United States and Canadian Academy
of Pathology Meeting, Washington, DC, 2003)
24
Maitra, Anirban
52.
Swierczynski SL, Argani P, Iacobuzio-Donahue CA, Ashfaq R, Cameron JL, Yeo CJ, Rahman A, Hruban
RH, Maitra A. Development and Validation of Tissue Microarrays in Pancreatic Cancer (92nd United States
and Canadian Academy of Pathology Meeting, Washington, DC, 2003)
53.
Swierczynski SL, Maitra A, Abraham SC, Iacobuzio-Donahue CA, Ashfaq R, Schulick RD, Rahman A, Yeo
CJ, Hruban RH, Argani P. Identification of Novel Tumor Markers in Biliary Carcinomas Using Tissue
Microarrays (92nd United States and Canadian Academy of Pathology Meeting, Washington, DC, 2003)
54.
van Heek NT, Meeker AK, Kern SE, Goggins MG, Offerhaus GJ, Demarzo AM, Hruban RH, Maitra A.
Telomere Shortening Is Nearly Universal in Pancreatic Intraepithelial Neoplasia (92nd United States and
Canadian Academy of Pathology Meeting, Washington, DC, 2003)
55.
Meeker AK, Hicks JL, Argani P, Maitra A, Iacobuzio-Donahue CA, Montgomery EA, Westra WH, De
Marzo AM. Direct Evidence of Telomere Shortening in a Wide Range of Human Epithelial Pre-Cancerous
Lesions (92nd United States and Canadian Academy of Pathology Meeting, Washington, DC, 2003)
56.
Koopmann J, Fedarko N, Jain A, Maitra A, Iacobuzio-Donahue CA, Yeo CJ, Hruban RH, Goggins MG.
Evaluation of Osteopontin as Biomarker for Pancreatic Adenocarcinoma (Digestive Diseases Week, Orlando,
2003)
57.
van Heek NT, Maitra A, Koopmann J, Fedarko N, Jain A, Rahman A, Iacobuzio-Donahue CA, Adsay V,
Ashfaq R, Yeo CJ, Cameron J, Offerhaus J, Hruban RH, Berg K, Goggins MG. Identification of Osteopontin
as a serum marker of ampullary carcinoma by gene expression profiling (Digestive Diseases Week, Orlando,
2003)
58.
Henke RT, Maitra A, Gvozdjan D, Tassi E, McDonnell K, Wellstein A. Expression of newly discovered
metastasis genes in tissue microarrays of gastrointestinal cancers is predictive of metastasis status (94 th
American Association of Cancer Research Meeting, Washington, DC, 2003)
59.
Rathi A, Virmani A, Harada K, Miyajima K, Maitra A, Timmons CF, Gazdar AF. Aberrant methylation of
the HIC1 promoter is a frequent event in specific pediatric neoplasms (94 th American Association of Cancer
Research Meeting, Washington, DC, 2003)
60.
House MG, Wistuba II, Argani P, Guo M, Schulick RD, Hruban RH, Herman JG, Maitra A.
Hypermethylation of tumor suppressor genes in gallbladder cancer (Society of Surgical Oncology Annual
Meeting, Los Angeles, 2003)
61.
House MG, Guo MZ, Herman JG, Schulick RD, Cameron JL, Hruban RH, Maitra A, Yeo CJ. Aberrant
hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms (American Surgical
Association Annual Meeting, Washington, DC, 2003)
62.
House MG, Guo MZ, Hooker CM, Herman JG, Schulick RD, Cameron JL, Hruban RH, Maitra A, Yeo CJ.
Prognostic value of hMLH1 hypermethylation and microsatellite instability in surgically resected endocrine
tumors of the pancreas (American Association of Endocrine Surgeons Annual Meeting, San Diego, 2003).
63.
Amador ML, Maitra A, Gruenwald V, Peralba JM, Hidalgo M. Determinants of resistance to OSI-774 in
billiary tract carcinoma cell lines. (American Society of Clinical Oncology Annual Meeting, Chicago, IL
2003)
25
Maitra, Anirban
64.
Amador ML, Oppenheimer D, Maitra A, Embuscado E, Iacobuzio-Donahue C, Hidalgo M. Genetic-based
rational combination of Zd1839 and Ci-1040 in billiary tract carcinoma (Gastrointestinal Cancer Symposium,
American Society of Clinical Oncology, 2004)
65.
Montgomery E, Zhang S, Mamelak A, Maitra A, Sheikh S, Amr S, Yang S, Brock M, Forastiere A, Berg K.
Claudin gene overexpression in esophageal adenocarcinoma and its precursors. (93rd United States and
Canadian Academy of Pathology Meeting, Vancouver, British Columbia, 2004)
66.
Hansel DE, Wilentz RE, Yeo CJ, Schulick RD, Montgomery E, Maitra A. Expression of neuropilin-1 in high
grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tract. (93rd United States and
Canadian Academy of Pathology Meeting, Vancouver, British Columbia, 2004)
67.
Maitra A, Cao D, Albores-Saavedra J, Klimstra D, Hruban RH. Expression of epithelial markers in
nonductal neoplasms of the pancreas. (93rd United States and Canadian Academy of Pathology Meeting,
Vancouver, British Columbia, 2004)
68.
Hansel DE, Maitra A, Lin J, Yeo CJ, Leach SD, Biankin AV. Expression of CDX 1 and 2 distinguishes
periampullary lesions by site of origin, tumor stage, metastatic potential, and patient outcome. (93rd United
States and Canadian Academy of Pathology Meeting, Vancouver, British Columbia, 2004)
69.
Cao D, Sato N, Maitra A, Hruban RH, Goggins M. Expression of two novel epithelial markers fascin and
cystatin c- in intraductal pancreatic mucinous neoplasms (IPMNs) of the pancreas. (93rd United States and
Canadian Academy of Pathology Meeting, Vancouver, British Columbia, 2004)
70.
Klimstra DS, Takaori K, Hruban RH, Adsay NV, Albores-Saavedra J, Biankin AV, Biankin SA, Compton
CC, Fukushima N, Furukawa T, Goggins M, Kato Y, Kloeppel G, Longnecker D, Luettges J, Maitra A,
Offerhaus GJ, Shimizu M, Yonezawa S. Consensus Criteria for the Classification of Pancreatic
Intraepithelial Neoplasia (PanIN) and Intraductal Papillary Mucinous Neoplasms (IPMNs). (93rd United
States and Canadian Academy of Pathology Meeting, Vancouver, British Columbia, 2004)
71.
Prasad N, Biankin AV, Fukushima N, Maitra A, Elkahloun A, Goggins MG, Hruban RH, Leach SD.
Pancreatic intraepithelial neoplasia demonstrates features of gastric metaplasia. (Digestive Disease Week,
New Orleans, 2004)
72.
Kumar SK, Roy I, Denmeade SR, Isaacs JT, Maitra A, Khan SR. Nanoparticles as novel vectors for targeted
drug delivery to prostate cancer. (95th American Association of Cancer Research Meeting, Orlando, FL,
2004)
73.
Hansel DE, Dhara S, Maitra A, Montgomery E. CDC2/p34 upregulation and expression in a progression
model of esophageal adenocarcinomas. (95th American Association of Cancer Research Meeting, Orlando,
FL, 2004)
74.
Bashyam MD, Kim YK, Maitra A, Pollack JR. Localization of novel pancreatic cancer genes by CGH on
cDNA microarrays. (95th American Association of Cancer Research Meeting, Orlando, FL, 2004)
75.
Oppenheimer D, Amador ML, Maitra A, Rahman A, Perea S, Cusatis GA, Iacobuzio-Donahue C,
Embuscado E, Baker SD, Forastiere A, Hidalgo M. Polymorphisms of intron 1 of the epidermal growth factor
receptor (EGFR) affects the response to the EGFR tyrosine kinase inhibitor OSI-774. (95th American
Association of Cancer Research Meeting, Orlando, FL, 2004)
26
Maitra, Anirban
76.
Hingorani SR, Petricoin EF, Maitra A, King C, Jacobetz MA, Yoshiya K, Crawford HC, Putt ME, Jacks T,
Konieczny SF, Wright CV, Hruban RH, Lowy A, Tuveson DA. Endogenous KRASG12D expression induces
pancreatic intraepithelial neoplasia (PanIN) in mice with a definable proteomic signature. (95 th American
Association of Cancer Research Meeting, Orlando, FL, 2004)
77.
Hansel D, Dhara S, Huang R, Deasel M, Ashfaq R, Shimada Y, Bernstein H, Harmon J, Brock M, Forestiere
A, Washington K, Maitra A, Montgomery E. CDC2/CDK1 Expression in Esophageal Adenocarcinoma and
Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target
(94th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, Texas, March
2005)
78.
Montgomery E, Cunningham S, Schulick R, Yeo C, Haque R, Hammoud S, Hustinx S, Kim M, IacobuzioDonahue C, Ashfaq R, Kamangar F, Maitra A. Identification of Novel Cellular Targets in the Progression
Model of Gastric Adenocarcinoma (94th Annual Meeting of the United States and Canadian Academy of
Pathology, San Antonio, Texas, March 2005)
79.
Yang G-Y, Dilworth HP, Ashfaq R, Hruban RH, Maitra A. Tissue Transglutaminase II: A Biomarker of
Pancreatic Ductal Adenocarcinoma (94th Annual Meeting of the United States and Canadian Academy of
Pathology, San Antonio, Texas, March 2005)
80.
Chandrasekharan A, Shi C, Thuluvath PJ, Wistuba II, Karikari CA, Argani P, Goggins MG, Eshleman JR,
Maitra A. Ultrasensitive Detection of KRAS Mutations in Bile and Serum from Patients with Biliary Cancer
Using LigAmp Technology (94th Annual Meeting of the United States and Canadian Academy of Pathology,
San Antonio, Texas, March 2005)
81.
Hustinx SR, Hruban RH, Leoni LM, Argani P, Ashfaq R, Goggins MG, Kern S, Maitra A. Homozygous
Deletion of the MTAP Gene in Invasive Adenocarcinoma of the Pancreas and in Periampullary Cancer: A
Potential New Target for Therapy (94th Annual Meeting of the United States and Canadian Academy of
Pathology, San Antonio, Texas, March 2005)
82.
Hustinx SR, Maitra A, Leoni LM, Ashfaq R, Goggins MG, Iacobuzio-Donahue C, Kern S, Hruban RH.
Concordant Loss MTAP and p16/CDKN2A Expression in Pancreatic Intraepithelial Neoplasia: Evidence of
Homozygous Deletion in a Non-Invasive Precursor Lesion (94th Annual Meeting of the United States and
Canadian Academy of Pathology, San Antonio, Texas, March 2005)
83.
Hustinx SR, Cao D, Hruban RH, Sato N, Martin S, Sudhir D, Iacobuzio-Donahue C, Kern S, Goggins MG,
Pandey A, Maitra A. Differentially Expressed Genes in Pancreatic Ductal Adenocarcinomas Identified
through Serial Analysis of Gene Expression: An Update (94th Annual Meeting of the United States and
Canadian Academy of Pathology, San Antonio, Texas, March 2005)
84.
Maitra A, Cao D, Lee K, Itami A, Hruban RH, Ouellette M. The Tubulin Beta-4 Polypeptide (TUBB4), a
Marker of Resistance to Taxanes, Is Overexpressed in Pancreatic Intraepithelial Neoplasia and Pancreatic
Ductal Adenocarcinoma (94th Annual Meeting of the United States and Canadian Academy of Pathology, San
Antonio, Texas, March 2005)
85.
Zhang H, Basturk O, Othman M, Cheng JD, Khayyata SH, Maitra A, Hruban RH, Adsay NV. Expression of
MUC1, MUC2, MUC5AC and CDX2 in Carcinomas of the Gallbladder and Extrahepatic Bile Duct (94 th
Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, Texas, March
2005)
27
Maitra, Anirban
86.
Cao D, Kassaui K, Argani P, Neumann C, Ho L, Abbruzzese J, Ouellette M, Maitra A. Expression of Two
Novel Tumor Markers, Maspin and Tubulin beta Polypeptide (TUBB), in Biliary Cancers (94 th Annual
Meeting of the United States and Canadian Academy of Pathology, San Antonio, Texas, March 2005)
87.
Henke RT, Kim SE, Fang WJ, Maitra A, Wellstein A. Outcome in Patients with Colorectal Adenocarcinoma
in Relation to the Expression of the Growth Factor Pleiotrophin and Its Receptor Anaplastic Lymphoma
Kinase (Poster presentation at the 94th Annual Meeting of the United States and Canadian Academy of
Pathology, San Antonio, Texas, March 2005)
88.
Powell EL, Montgomery E, Leoni L, Maitra A. Concordant Loss of MTAP and p16/CDKN2A Expression in
Barrett Esophagus and Adenocarcinoma: Evidence of Homozygous Deletion in Non-Invasive Precursor
Lesions (94th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, Texas,
March 2005)
89.
Maitra A, Cao D, Neumann C, Abbruzzese J, Ho L. Aberrant Expression of Maspin in Idiopathic
Inflammatory Bowel Disease Is Associated with Disease Activity and Neoplastic Transformation (94 th
Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, Texas, March
2005)
90.
Salaria S, Cronin M, Kim E, Zhang Q, Maitra A, Neumann C, Hruban RH, Goggins MG, Abbruzzese J, Ho
L. Maspin Is Overexpressed in the Majority of Pancreatic Ductal Adenocarcinomas and Pancreatic
Intraepithelial Neoplasia (PanIN) Lesions: A Potential Biomarker for Early Detection (94 th Annual Meeting
of the United States and Canadian Academy of Pathology, San Antonio, Texas, March 2005)
91.
Hansel DE, Maitra A, House MG, Yeo CJ, Ali SZ. Differential Expression of Neuroendocrine Markers in
Liver Metastases of Cancers of Unknown Primary (94th Annual Meeting of the United States and Canadian
Academy of Pathology, San Antonio, Texas, March 2005)
92.
Rubio-Viqueira B, Jimeno A, Iacobuzio-Donahue C, Maitra A, Bouraoud N, Yeo C, Altiok S, Hidalgo M.
Novel in vivo model for drug development in pancreas cancer (96th Annual Meeting of the American
Association for Cancer Research, Anaheim, CA, April 2005)
93.
Hansel DE, Wehner S, Herzog V, Maitra A. Alterations in Gene Expression in Pancreatic Cancer Cell Lines
Induced by the N-terminal Fragment of APP (sAPP) (96th Annual Meeting of the American Association for
Cancer Research, Anaheim, CA, April 2005)
94.
Shi C, Chandrashekharan A, Thuluvath PJ, Wistuba II, Karikari C, Argani P, Goggins MG, Maitra A,
Eshleman JR. Ultrasensitive Detection of KRAS2 Mutations in Bile and Serum from Patients with Biliary
Cancer using LigAmp Technology (96th Annual Meeting of the American Association for Cancer Research,
Anaheim, CA, April 2005)
95.
Mullendore ME, Fan X, Eberhart C, Matsubayashi H, Ouellette M, Li Y, Maitra A. Notch signaling in
pancreas cancer (Late-breaking abstract at the 96th Annual Meeting of the American Association for Cancer
Research, Anaheim, CA, April 2005)
96.
Kumar S, Roy I, Maitra A, Beachy P, Khan SR. Targeted inhibition of hedgehog signaling by cyclopamine
prodrug for advance prostate cancer (Late-breaking abstract at the 96th Annual Meeting of the American
Association for Cancer Research, Anaheim, CA, April 2005)
28
Maitra, Anirban
97.
Rakheja D, Leos N, Mullendore M, Maitra A, Margraf L. Mutation of Mitotic Spindle Checkpoint Gene
BUB1B in Mosaic Variegated Aneuploidy (Joint Meeting of the Society for Pediatric Pathology/Pediatric
Pathology Society, Tours, France, September 2005)
98.
Brune KA, Abe T, Canto MI, O'Malley L, Klein AP, Maitra A, Adsay NV, Fishman E, Cameron JL, Yeo CJ,
Kern SE, Goggins MG, Hruban RH. Multifocal Neoplastic Precursor Lesions Associated with Lobular
Atrophy of the Pancreas in Patients Having a Strong Family History of Pancreatic Cancer (Poster
presentation at the 95th Annual Meeting of the United States and Canadian Academy of Pathology, Atlanta,
Georgia, February, 2006)
99.
Cao D, Adsay NV, Maitra A, Antonescu C, Klimstra D, Hruban RH. Expression of c-kit in Solid
Pseudopapillary Tumor of the Pancreas (Poster presentation at the 95 th Annual Meeting of the United States
and Canadian Academy of Pathology, Atlanta, Georgia, February, 2006)
100. Zhou S, Kassauei K, Poeta ML, Cutler DJ, Koch W, Sidransky D, Maitra A, Califano J. Detection of
mitochondrial DNA mutations in head and neck cancers (Poster presentation at the 97 th Annual Meeting of
the American Association for Cancer Research, Washington, DC, April 2006)
101. Kristiansen T, Gronborg M, Harsha HC, Goggins MG, Maitra A, Pandey A. Quantitative proteomics for
identification of membrane proteins as biomarkers for pancreatic cancer (Poster presentation at the 97th
Annual Meeting of the American Association for Cancer Research, Washington, DC, April 2006)
102. Weekes CD, Rubi-Viquera B, Zhang X, Jimeno A, Maitra A, Hidalgo M. Stromal derived factor 1 alpha
mediates resistance to mTOR inhibition by the preservation of hypoxia inducible factor 1 alpha expression
(Platform presentation at the 97th Annual Meeting of the American Association for Cancer Research,
Washington, DC, April 2006)
103. Jimeno A, Rubio-Viquera B, Peralba J, Zhang X, Bouraoud N, Cusatis G, Chan A, Singh S, Hirsch F, Mills
G, Kulescza P, Altiok S, Iacobuzio-Donahue C, Maitra A, Hruban R, Hidalgo M. Combined targeted therapy
shows increased efficacy in a novel in vivo pancreas cancer model (Poster presentation at the 97th Annual
Meeting of the American Association for Cancer Research, Washington, DC, April 2006)
104. Jagadeeswaran R, Ahmed S, Janamanchi V, Surawska H, Karikari C, Maitra A, Salgia R. c-met Receptor
tyrosine kinase: a novel molecular therapeutic target for the treatment of pancreatic cancer (Poster
presentation at the 97th Annual Meeting of the American Association for Cancer Research, Washington, DC,
April 2006)
105. Hidalgo M, Rubio-Viqueira B, Weekes C, Song D, Shah P, Messersmith W, Messersmith W, Altiok S,
Kulesza P, Maitra A, Jimeno A. (Platform presentation at the 2006 ASCO Annual Meeting)
106. Rubio-Viqueira B, Mezzadra H, Iacobuzio-Donahue C, Jimeno A, Zhang X, Maitra A, Altiok S, Hidalgo M.
Optimizing targeted agents development in pancreatic cancer: A fine-needle aspirate biopsy (FNAB) based
ex vivo and in vivo assay (Platform presentation at the 2006 ASCO Annual Meeting)
107. Alvarez H, Riggins G, Roa JC, Diaz A, Pimentel F, Ibanez L, Maitra A, Corvalan AH. Serial analysis of
gene expression identifies novel candidate markers for gallbladder cancer (Poster presentation at the 2007
ASCO Gastrointestinal Cancers Symposium)
108. Krizman D, Darfler M, Maitra A, Hood B, Conrads T. Proteomic identification of biomarkers of precursor
lesions of pancreatic cancer (Poster presentation at the 98th Annual Meeting of the American Association for
Cancer Research, Los Angeles, CA, April 2007)
29
Maitra, Anirban
109. Alvarez HA, Corvalan A, Argani P, Roa JC, Diaz A, Pimentel F, Ibañez L, Riggins G, Maitra A.
Transcriptomic profiling in a multiethnic gallbladder cancer study identifies novel candidate genes for
targeted therapy (Poster presentation at the 98th Annual Meeting of the American Association for Cancer
Research, Los Angeles, CA, April 2007)
110. Tsuji K, Yang M, Jiang P, Maitra A, Kausha S, Yamauchi K, Katz MH, Moossa AR, Hoffman RM, Bouvet
M. Common bile duct injection as a novel method for establishing RFP-expressing human pancreatic cancer
in nude mice (Poster presentation at the 98th Annual Meeting of the American Association for Cancer
Research, Los Angeles, CA, April 2007)
111. Kwei KA, Bashyam M, Maitra A, Van de Rijn M, Montgomery K, Pollack JR. Role of SMURF1
amplification in pancreatic oncogenesis (Poster presentation at the 98th Annual Meeting of the American
Association for Cancer Research, Los Angeles, CA, April 2007)
112. Karanjawala ZE, Illei PB, Ashfaq R, Infante J, Murphy K, Maitra A, Goggins M, Hruban RH. New Markers
of Pancreatic Cancer Identified through Differential Gene Expression (Poster presentation at the 96th Annual
Meeting of the United States and Canadian Academy of Pathology, San Diego, CA, March 2007)
113. Cheung WL, Krizman DB, Alvarez H, Hood BL, Darfler MM, Veenstra TD, Mollenhauer J, Habbe N,
Feldman G, Maitra A. Application of a Global Proteomic Approach to Archival Precursor Lesions:
Upregulation of DMBT-1 and TG2 in Pancreatic Cancer Precursors (Poster presentation at the 97th Annual
Meeting of the United States and Canadian Academy of Pathology, Denver, CO, March 2008)
114. Hristov AC, Di Cello F, Delos Reyes M, Singh M, Smail S, Karikari CA, Maitra A, Resar LMS. Expression
of High Mobility Group A (HMGA1) Proteins in Pancreatic Ductal Adenocarcinoma (PDA) (Poster
presentation at the 97th Annual Meeting of the United States and Canadian Academy of Pathology, Denver,
CO, March 2008
115. Kamiyama H, Lin MT, Kamiyama M, Hua L, Karikari C, Fu B, Klein AP, Goggins MG, Hruban RH, Maitra
A, Iacobuzio-Donahue CA, Eshleman JR. Ten new familial pancreatic cancer cell lines. Poster presentation
at 100th Annual Meeting American Association for Cancer Research, Denver, CO April 2009
116. Rasheed Z, Yang J, Wang Q, Freed I, Koorstra J-B, Hong S-M, He X, Berman D, Laheru D, Hidalgo M,
Jimeno A, Maitra A, Matsui W. The functional stem cell marker aldehyde dehydrogenase enhances
pancreatic cancer stem cell isolation and correlates with clinical prognosis. Platform presentation at 99th
Annual Meeting of the American Association for Cancer Research, San Diego, CA April 2008
117. Shields D, Niessen S, Barnes L, Maitra A, Bouvet M, Cravatt B, Cheresh D. Identification of a novel
regulator of pancreatic tumorigenesis by multidimensional activity-based proteomic analysis. Proffered
poster presentation at 99th Annual Meeting of the American Association for Cancer Research, San Diego,
CA April 2008
118. Kamiyama H, Hua L, Luo M, Kamiyama M, Klein A, Hruban R, Iacobuzio-Donahue C, Maitra A, Goggins
M, Eshleman J. Gene identification for familial pancreatic cancer through nonsense-mediated mRNA decay
inhibition. Poster presentation at 99th Annual Meeting of the American Association for Cancer Research,
San Diego, CA April 2008
119. Mishra1 A, Feldmann G, Garrido-Laguna1 I, Dadon T, Strock CJ, Bannerji R, Hidalgo M, Maitra A, Nelkin
BD. SCH727965, a novel potent cyclin dependent kinase inhibitor, inhibits pancreatic tumor growth and Ras-
30
Maitra, Anirban
mediated tumorigenic signaling. Poster presentation at the AACR-NCI-EORTC Molecular Targets and
Cancer Therapeutics meeting, Boston, MA, November 2009
120. Rajeshkumar NV, De Oliveira E, Ottenhof NA, Garrido-Laguna1 I, Villarroel MC, Watters J, Demuth T,
Brooks D, Mizuarai S, Hirai H, Maitra A, Hidalgo M. MK-1775, a potentWee1 inhibitor, synergizes with
gemcitabine to achieve tumor regressions in pancreatic tumor xenografts. Poster presentation at the AACRNCI-EORTC Molecular Targets and Cancer Therapeutics meeting, Boston, MA, November 2009
121. Maitra A, Rajeshkumar NV, Rudek M, Garrido-Laguna I, Laheru D, Iglesias J, Desai N, Von Hoff DD,
Hidalgo M. nab®-paclitaxel targets tumor stroma and results, combined with gemcitabine, in high efficacy
against pancreatic cancer models. Poster presentation at the AACR-NCI-EORTC Molecular Targets and
Cancer Therapeutics meeting, Boston, MA, November 2009 (Featured in NCI Bulletin).
122. Jockovic K, Schultz L, Sharma R, Maitra A, Illei PB, Hruban RH, Netto GJ. PSMA Expression in Pancreatic
Endocrine Neoplasms: A Potential Diagnostic Pitfall. Poster presentation at the 99th Annual Meeting of the
United States and Canadian Academy of Pathology, Washington DC March 2010
123. Jockovic K, Hruban RH, Schultz L, Sharma R, Maitra A, Illei PB, Netto GJ. PAX8 Expression in Pancreatic
Endocrine Neoplasms: Diagnostic Pitfall and Potential Prognostic Role. Poster presentation at the 99th
Annual Meeting of the United States and Canadian Academy of Pathology, Washington DC March 2010
124. Lin M, Scrimieri F, Nguyen T, Wolfgang CL, Iacobuzio-Donahue C, Maitra A, Goggins M, Eshleman J,
Olino K, Kern SE, Hruban RH. Loss of BRG1/SMARCA4 Expression in Pancreatic Ductal Adenocarcinoma.
Poster presentation at the 99th Annual Meeting of the United States and Canadian Academy of Pathology,
Washington DC March 2010
125. Park JY, Hong SM, Goggins M, Maitra A, Hruban RH. Pdx1 Expression in Precursor Lesions and
Neoplasms of the Pancreas. Poster presentation at the 99th Annual Meeting of the United States and Canadian
Academy of Pathology, Washington DC March 2010
126. Shi C, Siegelman SS, Kawamoto S, Wolfgang CL, Schulick RD, Maitra A, Hruban RH. Dramatic Pancreatic
Duct Strictures Secondary to Small Endocrine Neoplasms: A Manifestation of Serotonin Production? Poster
presentation at the 99th Annual Meeting of the United States and Canadian Academy of Pathology,
Washington DC March 2010
127. Khan M, Bisht S, Maitra A, Anders RA. Nanocurcumin Formulation Increases Bioavailability of Curcumin
and Prevents Experimentally Induced Liver Fibrosis. Poster presentation at the 99th Annual Meeting of the
United States and Canadian Academy of Pathology, Washington DC March 2010
128. Lim KJ, Maitra A, Bisht S, Eberhart C, Bar E. Using nanocurcumin to treat medulloblastoma and
glioblastoma. Poster Presentation at the 101st Annual Meeting of the American Association for Cancer
Research, Washington DC, April 2010
129. Hillion J, Di Cello F, Smail S, Griffin M, Cope L, Maitra A, Huso D, Resar L. The HMGA1-COX-2 axis: A
molecular pathway leading to tumor progression in human pancreatic adenocarcinoma? Poster Presentation at
the 101st Annual Meeting of the American Association for Cancer Research, Washington DC, April 2010
130. Le A, Cooper CR, Gouw A, Maitra A, Dinavahi R, Deck L, Royer R, Vander Jagt D, Semenza G, Dang CV.
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Poster
Presentation at the 101st Annual Meeting of the American Association for Cancer Research, Washington DC,
April 2010
31
Maitra, Anirban
131. Maeda Y, Xiao W, Liu R, Uriyama S, Maitra A, Lam K, Kumaresan PR. Development of pancreatic cancer
specific targeting agents as imaging agents. Poster Presentation at the 101st Annual Meeting of the American
Association for Cancer Research, Washington DC, April 2010
132. Kamiyama H, Kamiyama M, Hong SM, Karikari C, Lin MT, Griffith M, Young A, Kirby A, Borges M,
Lubek C, Mizuma M, Feldman G, Shi C, Liang H, Goggins M, Maitra A, Hruban R, Eshleman J. In vivo and
in vitro propagation of Intraductal Papillary Mucinous Neoplasms. Poster Presentation at the 101st Annual
Meeting of the American Association for Cancer Research, Washington DC, April 2010
133. Tsiatis AC, Hafez MJ, Jedlicka AE, Maitra A, Murphy KM, Eshleman JR. Use of SNP arrays to assess loss
of heterozygosity in gliomas. Poster Presentation at the 101st Annual Meeting of the American Association
for Cancer Research, Washington DC, April 2010
134. Liby KT, Royce D, Risingsong R, Williams C, Maitra A, Sporn MB. The synthetic triterpenoid CDDOmethyl ester and the rexinoid LG100268 extend survival in the KPC transgenic mouse model of pancreatic
cancer. Platform Presentation at the 101st Annual Meeting of the American Association for Cancer Research,
Washington DC, April 2010
Inventions, Patents, Copyrights
1. Pancreatic cancer diagnosis and therapies (US 2003/0180747 A1)
2. Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differential gene expression (US
2005/0084883 A1)
3. Cancer treatment with gamma-secretase inhibitors (US 2008/0058316 A1)
4. Water-dispersible oral, parenteral and topical formulations for poorly water-soluble drugs using smart polymeric
nanoparticles (US 2008/0107749 A1)
5. Elevated Hedgehog Pathway Activity In Digestive System Tumors, And Methods Of Treating Digestive Sytem
Tumors Having Elevated Hedgehog Pathway Activity (US 2008/0118493 A1)
Extramural Funding
ACTIVE
Grants:
03/01/10-02/28/15; Developmental Signaling Pathways in Pancreatic Cancer
R01 CA113669 (Competing Continuation)
NIH/NCI
$964,415 TDC
P.I.: Maitra
Role: P.I., 15% effort
Notes: The goal of this project is to target the Hedgehog (Hh) and Notch signaling pathways in pancreatic cancer.
09/01/05-08/31/10; Multifunctional nanoparticles in diagnosis and therapy of pancreatic cancer
R01 CA119397
32
Maitra, Anirban
NIH/ NCI
$1,060,010 TDC
P.I.: Prasad, SUNY at Buffalo
Role: P.I. Subcontract; 1% effort
Notes: The objective of this project is to develop hybrid ceramic-polymeric nanoparticles that can be utilized for
targeted imaging and drug delivery in pancreas cancer.
07/01/07-06/30/12; SPORE in Gastrointestinal Cancer (Maitra Project 3C)
2P50 CA062924
NIH
$7,946,234 TDC
P.I.: Kern
Role: P.I. Project C, 16% effort
Notes: The goal of this project is to identify the genetics of precursor lesions of pancreatic cancer and develop
biomarkers for biological classification and risk stratification in these lesions.
07/01/08-05/31/13; Targeting CDK5 in Pancreatic Cancer: Mechanistic and Preclinical Development
R01 CA134767
NIH
$1,250,000 TDC
P.I.: Nelkin/Maitra (Multi-PI)
Role: P.I. (Multi-P.I.); 15% effort
Notes: The goal of this project is to develop CDK5 as a potential therapeutic target for the control of pancreatic
cancer.
09/01/08-07/31/12; Novel Human Cancer Cell Isolation System
R01 CA130938
NIH/NCI
$747,000 TDC
P.I.: Eshleman
Role: co-P.I., 2% effort
Notes: The goal of this project is to make biochemically defective mice that support human cancer growth, but
when these cancers are transferred to tissue culture, the mouse cells can be easily eliminated. We plan to
demonstrate that the new mice are superior in producing cell lines and recovery of metastases.
12/01/08-06/30/11; Inhibition of Hedgehog Signaling by Cyclopamine Prodrug for Prostate Cancer
FAMRI 062563_CIA
Flight Attendant Medical Research Institute
$200,000 TDC
P.I.: Maitra
Role: P.I., 10% effort
Notes: The objective is to synthesize PSMA-cleavable cyclopamine prodrugs.
04/15/09-03/31/14; Functional Annotation of the Pancreatic Cancer Genome
P01 CA134292-A1
NIH/NCI
$5,650,000 TDC
P.I.: Leach
Role: P.I. Project 3, 16% effort
Notes: Dr. Maitra is the Project Leader of Project 3 in this P01. The goal of Project 3 is to functionally
characterize the Hippo signaling pathway in pancreatic cancer using zebrafish and mammalian models.
33
Maitra, Anirban
09/30/09-08/31/11; Predicting Pancreatic Cancer Responses for a PARP Inhibitor-Based Clinical Trial
RC2 CA148346
NIH/NCI
$962,168 TDC
P.I.: Goggins
Role: co-P.I., 10% effort
Notes: The aim of this project if to treat patients with advanced pancreatic cancer with an orally bioavailable PARP
inhibitor and correlate responses with the underlying mutational status of the tumor.
07/01/09-06/30/12; Stand Up to Cancer
No Identification Number
AACR
$6,756,104 TDC
P.I.: Dang
Role: P.I. Project A, co-P.I. Project B, 6% effort
Notes: The aim of the SU2C umbrella project is to develop new therapies for lethal pancreatic cancer. Project A
will target cancer metabolism using a number of small molecule inhibitors, and Project B will develop
individualized therapies for pancreatic cancer using an in vivo xenograft model.
03/01/10-02/28/11; Multi-Center CEBE Trial
ISC-1000
Pentax Medical Corp.
$388,100 TDC
P.I.: Canto
Role: co-P.I., 5% effort
Notes: The goal of this project is to demonstrate that EM is an accurate endoscopic technology that will increase
the diagnostic yield of mucosal biopsy for diagnosis of IEN in BE patients evaluated with high resolution white
light endoscopy (HRE) due to more selective tissue acquisition.
Contracts: None.
Other: None.
PENDING
Grants:
07/01/10-06/30/15; Cancer Nanotechnology Excellence at Johns Hopkins
R25 CA153952 (Received a priority score of 21)
NIH
$1,943,800 TDC
P.I.: Wirtz and Maitra
Role: co-P.I., 8% effort
Notes: The objective of this project is to train fellows at the interface between nanotechnology and cancer medicine
to develop novel nanoscale therapeutic and diagnostic tools for the detection, treatment and cure of human cancer.
34
Maitra, Anirban
09/01/10-08/31/15; Center of Cancer Nanotechnology Excellence at Johns Hopkins
U54 CA151838 (Received a priority score of 28)
NIH
$9,819,713 TDC
P.I.: Searson
Role: co-P.I., 10% effort
Notes: The objective of the Center is to integrate nanotechnology-based diagnostic and therapeutic tools for
comprehensive cancer care. Through the fou inter-related projects described in this proposal we envision a set of
integrated nanotechnology-based solutions for diagnosis, therapy, and post-therapy monitoring. Advances in
cancer nanomedicine provide tremendous potential to improve to improve clinical practice.
09/01/10-08/31/15; Preclinical application of targeted “theranostic” nanoparticles in pancreatic cancer
U01 CA151801
NIH
$374,410 TDC
P.I. Prasad, SUNY at Buffalo
Role: P.I. Subcontract, 5% effort
Notes: The goal of this project is to develop a preclinical treatment protocol for PLGA-Dox in orthotopic xenograft
models of pancreatic cancer and in transgenic model of pancreatic cancer.
12/01/10-11/30/12; Analysis of Notch Pathway Inhibitors in Pancreas Cancer
R21 CA155259
NIH
$109,128 TDC
P.I.: Laheru (University of Colorado)
Role: co-P.I., 5% effort
Notes: The main goal is to test an inhibitor to an over-expressed pancreatic cancer pathway known as NOTCH
signaling in patients with gemcitabine refractory pancreatic cancer.
Contracts:
07/01/10-06/30/13; Targeted Therapeutics for Pancreatic Cancer
Contract
Sanofi-Aventis
$407,562 TDC
P.I.: Maitra
Role: P.I. Contract, 5% effort
Notes: The goal of this project is to develop targeted synthetic lethal therapies against pancreatic cancers with
known genetic mutations.
PREVIOUS
Grants:
01/01/02 –12/31/03; Genetic basis of familial pancreatic cancer: a novel approach using whole genome conversion
and oligonucleotide microarrays
LF01-009
Lustgarten Foundation for Pancreatic Cancer Research
$90,919 TDC
P.I.: Maitra
Role: P.I., 20% effort
Notes: The objective of this study was to examine somatic cell hybrids from patients with familial pancreatic
cancer to detect germline mutations in the mono-chromosomal milieu, using HuSNP gene chips.
35
Maitra, Anirban
04/01/02-06/30/03; Development of a human mitochondrial genome sequencing microarray (MITOChip) as a
universal tool for cancer detection
P50 CA62924 Pilot Project, SPORE in Gastrointestinal Cancer
NIH/NCI
$40,000 TDC
P.I.: Maitra
Role: P.I., 10% effort
Notes: The objective of this study was to develop a sequencing microarray for detection of mitochondrial mutations
in cancers and in clinical samples from cancer patients.
04/01/02-03/31/03; The Familial Pancreatic Cancer Gene Chip: Designing a high-throughput sequencing
microarray for risk assessment in familial pancreatic cancer
No Identification Number
National Pancreas Foundation
$60,000 TDC (no salary support)
P.I.: Maitra
Role: P.I., 10% effort
Notes: The objective of this study was to develop a sequencing microarray for germline mutation detection in
familial pancreatic cancer kindred.
01/01/03 –12/31/04; Locating novel pancreatic cancer genes with cDNA microarrays
LF03-33
Lustgarten Foundation for Pancreatic Research
$24,345 TDC
P.I.: Pollack, Stanford University
Role: P.I. Subcontract, 2% effort
Notes: The objective of this project was to perform comparative genomic hybridization on cDNA microarrays
using genomic DNA from pancreatic cancer cell lines and xenografts in order to detect deletions and
amplifications.
01/01/03 - 01/31/05; Serum-based biomarkers in biliary tract cancers
No Identification Number
Cancer Research and Prevention Foundation
$80,000 TDC
P.I.: Maitra
Role: P.I., 5% effort
Notes: The objective of this project was to develop serum ELISA for biomarkers identified using microarray-based
gene expression analysis of biliary cancers
07/01/03-06/30/04; Oncogenic pathways in biliary cancers
Johns Hopkins Clinician Scientist Award
Johns Hopkins School of Medicine
$24,809 TDC
P.I.: Maitra
Role: P.I., 22% effort
Notes: The objective of this study is to identify and target oncogenic signaling pathways in biliary cancers, for
potential mechanism based therapies.
01/01/04–12/31/05; Comprehensive array-based analysis of somatic mitochondrial mutations in smoking-related
gastrointestinal tract cancers
36
Maitra, Anirban
No Identification Number
Maryland Cigarette Restitution Fund
$75,000 TDC
P.I.: Maitra
Role: P.I.
Notes: The objective of this study is to determine the frequency of somatic mitochondrial mutations in smokingassociated gastro-esophageal and colorectal cancers arising in African American patients.
04/01/04-11/30/05; A sequencing microarray for mitochondrial mutations
R21/R33 CA107858
NIH/NCI
$249,937 TDC
P.I.: Maitra
Role: P.I., 5% effort
Notes: The objective of the study is to determine the feasibility of using mitochondrial mutations in pancreatic
juice as a biomarker for pancreas cancer.
07/01/04 - 05/31/05; Hedgehog Inhibitors in Pancreas Cancer
RFA04-040
Lustgarten Foundation for Pancreatic Research
$90,000 TDC
P.I.: Maitra
Role: P.I., 20% effort
Notes: This grant was rescinded due to overlap with R01CA113669-01
07/01/04-06/30/06; Notch Signaling in Pancreatic Cancer.
Career Development Award
AACR-PanCAN
$100,000 TDC (no salary support)
P.I.: Maitra
Role: P.I., 5% effort
Notes: The goals are 1) To characterize the in vitro effects of individual Notch receptors (Notch 1-3) on growth of
neoplastic and non-neoplastic pancreatic epithelial cell lines; 2) To characterize the in vitro effects of individual
Notch ligands (Jagged and the Delta-like ligand DLL1) on growth of neoplastic and non-neoplastic pancreatic
epithelial cell lines; 3) To determine the in vivo effects of pharmacological or genetic manipulation of the Notch
pathway in pancreatic cancer cells
01/01/05-12/31/06; Pharmacogenomics of Erlotinib
R21 CA109283
NIH/NCI
$250,000 TDC
P.I.: Hidalgo
Role: co-P.I., 5% effort
Notes: The goal is to develop pharmacogenomic determinants of Erlotinib activity.
04/01/05-03/31/10; Hedgehog Inhibitors in Pancreas cancer
R01 CA113669
NIH/NCI
$987,500 TDC
P.I.: Maitra
Role: P.I., 25% effort
37
Maitra, Anirban
Notes: The Specific Aims of the RO1 are as follows: (1) Determine the effects of Hh pathway blockade in
orthotopic xenografts derived from human pancreatic cancer using cyclopamine; (2) Study the role of Hh pathway
in a syngeneic mouse model of pancreatic adenocarcinoma; (3) Determine predictive biomarkers of resistance and
sensitivity to Hh inhibitors in pancreatic cancers.
08/01/05-07/31/07; Hedgehog signaling in pancreatic neoplasia
R21 DK072532
NIH/NIDDK
$250,000 TDC
P.I.: Maitra
Role: P.I., 10% effort
Notes: The goal is to determine the role of Hedgehog signaling in exocrine pancreatic injury/repair and neoplasia
using a novel transgenic mouse model of ectopic Hedgehog overexpression.
01/01/06-12/31/06; The role of microRNA’s in the pathogenesis of pancreatic cancer.
No Identification Number
Lustgarten Foundation for Pancreatic Research
$90,919 TDC
P.I.: Mendell
Role: co-P.I., 5% effort
Notes: The goal is to identify abnormally expressed microRNAs in human pancreatic cancers, and their functional
consequences.
04/01/06-03/31/11; Gene Amplification and Deletion in Pancreatic Cancer
R01 CA112016
NIH
$264,280 TDC
P.I.: Pollack, Stanford University
Role: P.I. Subcontract, 2%
Notes: The goals are to identify and map at high resolution gene amplifications and deletions in pancreatic cancer
and to identify the “driver” oncogene/TSG(s) within localized regions of CAN.
01/01/07-12/31/07; Synergistic targeting of the apoptotic machinery in pancreatic cancer
No Identification Number
Lustgarten Foundation for Pancreatic Research
$90,919 TDC
P.I.: Maitra
Role: P.I., 20% effort
Notes: The goal is to utilize small molecule inhibitors of X-linked IAP protein in combination with death receptor
agonist antibodies as a novel experimental therapy for pancreatic cancer.
01/01/07-12/31/07; Pancreatic Cancer Tumor Suppressor Gene Discovery Using Rnai
No Identification Number
Lustgarten Foundation for Pancreatic Research
$90,919 TDC
P.I.: Eshleman
Role: co-P.I., 1% effort
Notes: The goal is to discover new tumor suppressor genes for pancreatic cancer using a RNAi library-based
approach.
09/01/07-08/31/09; Novel tumor suppressor gene discovery in pancreatic cancer
38
Maitra, Anirban
R21 CA122265
NIH/NCI
$200,000 – No cost extension
P.I.: Eshleman
Role: co-P.I.; 0% effort
Notes: The goal of this project is to functionally identify tumor suppressor genes using whole genome shRNA
libraries.
01/01/08-12/31/08; Targeting the Herpes Virus Entry Mediator (HVEM) as a novel therapeutic strategy in
pancreatic cancer
No Identification Number
Lustgarten Foundation for Pancreatic Research
$90,919 TDC
P.I.: Maitra
Role: P.I., 20% effort
Notes: The goal is to test the approach that HVEM is a valid therapeutic target in pancreatic cancer, and that
blockage of the HVEM-BTLA interaction will result in the restitution of cytotoxic T cell activation in the tumoral
milieu and result in tumor growth inhibition, using conditional models of HVEM activation in vivo.
01/01/09-12/31/09; Ras-regulated microRNAs in pancreatic cancer
RFP09-150
The Lustgarten Foundation for Pancreatic Cancer Research
$100,000 TDC
P.I.: Mendell
Role: co-P.I., 1% effort
Notes: The goal of this project is to use cellular and animal models to investigate the contribution of microRNAs to
oncogenic Kras signaling.
Contracts:
12/01/06-11/30/08; Notch inhibitors in Human Pancreatic Cancer
Contract
Merck
$368,544 TDC
P.I.: Maitra
Role: P.I. Contract, 7% effort
The goal is to determine the therapeutic efficacy of small molecule Notch inhibitors in preclinical xenograft models
of pancreatic cancer.
09/18/07-09/17/08; Preclinical Evaluation of Nanocurcumin in Pancreatic Cancer
Contract
Sign Path Pharma, Inc.
$100,000 TDC
P.I.: Maitra
Role: P.I. Contract, 10% effort
Notes: The goal is to evaluate the therapeutic effects of polymeric nanoparticle encapsulated curcumin
(nanocurcumin) in xenograft models of pancreatic cancer
07/01/08-06/30/09; Evaluation of single agent and combination LDE225 in preclinical models of pancreatic cancer.
Contract
Novartis, Corp.
$31,861 TDC
39
Maitra, Anirban
P.I.: Maitra
Role: P.I. Contract, 2% effort
EDUCATIONAL ACTIVITIES
Educational Publications
Book Chapters
1. Gazdar AF, Maitra A. Tissue Microdissection and Processing In Cancer Treatment and Research: Cancer
Chemoprevention; Kluwer Academic Publishers, Norwell, MA, 2001.
2. Gazdar AF, Maitra A. Molecular Genetics of Human Adenocarcinomas In Encyclopedia of Genetics; Academic
Press, London, UK, 2001
3. Maitra A, Kumar V. The Respiratory System In Basic Pathology 7th Edition; Saunders Publications,
Philadelphia. PA, 2003
4. Maitra A, Kumar V. The Endocrine System In Basic Pathology 7th Edition; Saunders Publications, Philadelphia.
PA, 2003
5. Maitra A, Kumar V. Genetic and Pediatric Disorders In Basic Pathology 7th Edition; Saunders Publications,
Philadelphia. PA, 2003
6. Maitra A, Abbas A. The Endocrine System In Kumar, Abbas, Fausto (eds) Robbins’ Pathologic Basis of
Disease 7th Edition; Elsevier Health Sciences, Philadelphia, PA, 2004.
7. Maitra A, Kumar V. Diseases of Infancy and Childhood In Kumar, Abbas, Fausto (eds) Robbins’ Pathologic
Basis of Disease 7th Edition; Elsevier Health Sciences, Philadelphia, PA, 2004
8. Iacobuzio-Donahue C, Maitra A. Gene Expression Profiling In Current Problems in Cancer: Pancreatic Cancer;
Mosby, Inc., St. Louis, MO, 2002.
9. Hruban RH, Wilentz R, Maitra A. Identification and Analysis of Precursors to Invasive Pancreatic Cancer In
Pancreatic Cancer: Methods and Protocols, Humana Press, Totowa, NJ, 2004
10. Meeker AK, Gage WR, DeMarzo A, Maitra A. Direct in situ assessment of telomere length variation in human
cancers and preneoplastic lesions In Hayat (ed) Handbook of Immunohistochemistry and In Situ Hybridization of
Human Carcinomas, volume 2; Kluwer Academic Publishers, Norwell, MA, 2004.
11. Yeo CJ, Yeo TP, Hruban RH, Kern SE, Iacobuzio-Donahue C, Maitra A, Goggins MG, Canto MI,
Messersmith W, Abrahms R, Laheru D, Hidalgo M, Jaffee EM. Cancer of the Pancreas In DeVita, Hellman,
Rosenber (eds) CANCER: Principles and Practice of Oncology, Lippincott, Williams, and Wilkins, Philadelphia,
PA, 2004
12. Maitra A, Kumar V. Diseases of Infancy and Childhood In Kumar, Mitchell (eds) Pocket Companion to
Robbins’ Pathologic Basis of Disease 7th Edition; Elsevier Health Sciences, Philadelphia, PA, 2005
13. Maitra A, Abbas A. The Endocrine System In Kumar, Mitchell (eds) Pocket Companion to Robbins’
Pathologic Basis of Disease 7th Edition; Elsevier Health Sciences, Philadelphia, PA, 2005
40
Maitra, Anirban
14. Hruban RH, Maitra A, Kern SE. Precursors to invasive cancer of the pancreas In Nasir (ed) Cancer Growth
and Progression
15. Gronborg M, Maitra A, Pandey A. Proteomics of Human Pancreatic Juice In Thongboonkerd, V. (ed)
Proteomics of Human Body Fluids, Humana Press, Totowa, NJ, 2006, In press.
16. Kristiansen TZ, Maitra A, Pandey A. Proteomics of Human Bile In Thongboonkerd, V. (ed) Proteomics of
Human Body Fluids, Humana Press, Totowa, NJ, 2006, In press.
17. Maitra A, Yeo CJ. Genetics and Molecular Biology of Pancreatic and Biliary Cancers In Blumgart, L.H. (ed)
Surgery of the Liver, Biliary Tract, and Pancreas, 4th Ed, Elsevier Health Sciences, Philadelphia, PA, 2006
18. Fukushima N, Maitra A, Huban RH. Pathology of Pancreatic Cancer In Cameron, J.L, Berger, H.G, Matsuno,
S. (eds) Current Surgical Therapy, 9th Ed, Mosby Press, St. Louis, MO, 2006
19. Maitra A, Kern SE, Hruban RH. Molecular Pathogenesis of Pancreatic Cancer In Ghaneh, P, Neoptolemos,
J.P. (ed) Best Practice and Research Clinical Gastroenterology: Pancreatic Cancer, Elsevier Health Sciences
20:211-26; 2006
20. Beaty RM, Gronborg M, Pollack JR, Maitra A. Target Discovery and Validation in Pancreatic Cancer In
Methods in Molecular Biology: Target Discovery and Validation, Humana Press, Totowa, NJ, 360:57-89; 2007
21. Maitra A, Kumar V. The Endocrine System In Basic Pathology 8th Edition; Elsevier Health Sciences,
Philadelphia, PA, 2007
22. Maitra A, Kumar V. The Respiratory System In Basic Pathology 8th Edition; Elsevier Health Sciences,
Philadelphia, PA, 2007
23. Hruban RH, Brune K, Fukushima N, Maitra A. Pancreatic Intraepithelial Neoplasia In Pancreatic Cancer
(A.M. Lowy et al, eds.) Springer Science and Media, pg. 41-51, 2008.
24. Feldmann G, Maitra A. Molecular Pathology of Precursor Lesions of Pancreatic Cancer: Pancreatic
Intraepithelial Neoplasia (PanIN), Intraductal Papillary Mucinous Neoplasm (IPMN), and Mucinous Cystic
Neoplasm (MCN). In Handbook of Pancreatic Cancer: (Eds) Abbruzzese, Buchler, Neoptolemos, Urrutia.
Springer, New York, NY (2009).
25. Maitra A. The Endocrine System In Kumar, Abbas, Aster and Fausto (eds) Robbins’ Pathologic Basis of
Disease 8th Edition; Elsevier Health Sciences, Philadelphia, PA, 2009.
26. Maitra A. Diseases of Infancy and Childhood In Kumar, Abbas, Aster and Fausto (eds) Robbins’ Pathologic
Basis of Disease 8th Edition; Elsevier Health Sciences, Philadelphia, PA, 2009.
27. Feldmann G, Rauenzahn S, Maitra A. In vitro models of pancreatic cancer for translational oncology research.
Expert Opin Drug Discov. 2009 Apr 1; 4(4):429-443.
28. Hruban RH, Boffetta P, Hiraoka N, Iacobuzio-Donahue C, Kato Y, Kern SE, Klimstra DS, Kloppel G, Maitra
A, Offerhaus GA, Pitman MB. Ductal adenocarcinoma of the pancreas In WHO Classification of Tumours of the
Digestive System (Eds: Bosman, Hruban, Carneiro, Theise) 4th Edition, 2010 IARC Press, Lyons France.
41
Maitra, Anirban
29. Kloppel G, Hruban RH, Maitra A, Morohoshi T, Notohara K, Shimizu M, Terris B, Klimstra D. Solid
pseudopapillary neoplasm of the exocrine pancreas In WHO Classification of Tumours of the Digestive System
(Eds: Bosman, Hruban, Carneiro, Theise) 4th Edition, 2010 IARC Press, Lyons France.
30. Feldmann G, Maitra A. Methylation detection and epigenomics in pancreatic cancer In Drug Discovery in
Pancreatic Cancer (Eds Han and Grippo) Springer-Verlag, New York, NY 2010.
31. Matthaei H, Maitra A. Precursor lesions of pancreatic cancer In Advances in Understanding the Basic
Pathogenesis and Clinical Management of Pre-Invasive Disease (Eds Fitzgerald and Ponder) Springer-Verlag, New
York, NY 2010.
Case Studies
1. Maitra A, Weinberg AG. Inclusions in lymphoblasts. Ped Develop Pathol. 1998; 1:573.
2. Maitra A, Ward PJ, Jamal S, Kroft SH, Levinson BJ, Fishleder A, Sendelbach KM, McKenna RW. Cytoplasmic
inclusions in leukocytes: An unusual manifestation of cryoglobulinemia. Am J Clin Pathol. 2000; 113:107-12.
3. Maitra A, Ramnani DM, Margraf L, Gazdar AF. Synchronous Wilms tumor and fibrolamellar hepatocellular
carcinoma: report of a case. Ped Develop Pathol. 2000; 3:492-6.
4. Maitra A, Schneider NR, Weinberg AG, Patterson K. Detection of t(11;22)(q24;q12) translocation and EWSFLI-1 fusion transcript in a case of solid pseudopapillary tumor of the pancreas. Pediatr Develop Pathol. 2000;
3:603-5.
5. Maitra A, Timmons CF, Siddiqui M, Saboorian MH. Fine-needle aspiration biopsy features in a case of giant
cell fibroblastoma of the chest wall. Arch Pathol Lab Med. 2001; 125:1091.
6. Maitra A, Baskin L, Lee EL. Malignancies arising in oncocytic schneiderian papillomas: a report of 2 cases and
review of literature. Archives Pathol Lab Med. 2001; 125:1365.
7. Hoang M, Maitra A, Gazdar AF, Albores-Saavedra J. Primary mammary small-cell carcinoma: a molecular
analysis of 2 cases. Hum Pathol. 2001; 32:753-7.
8. Koorstra JB, Maitra A, Morsink FH, Drillenburg P, Ten Kate FJ, Hruban RH, Offerhaus JA. Undifferentiated
Carcinoma With Osteoclastic Giant Cells (UCOCGC) of the Pancreas Associated With the Familial Atypical
Multiple Mole Melanoma Syndrome (FAMMM). Am J Surg Pathol. 2008; 32:1905-9.
Teaching
Classroom Instruction
Medical School (Sophomore Year Pathology Course)
2001-Present
Pathology small group sessions (Cellular Injury and Inflammation, GI Tract)
Lab Instructor Johns Hopkins University
School of Medicine (~20 hours)
2003-2008
Impact of Genomics in Medicine
Lecturer
42
Johns Hopkins University
Maitra, Anirban
(Introductory lecture to Pathology lecture series)
2005-2009
Cellular Injury and Adaptation
Schoolof Medicine (1 hour)
Lecturer
Johns Hopkins University
School of Medicine (2 hours)
Medical School (1st Year "Genes to Society" Integrated Curriculum - replaces the 2nd Year Pathology Course)
2009-
Cellular Injury and Adaptation
Lecturer
Johns Hopkins University
School of Medicine (2 hours)
Residency and Fellowship Teaching Rounds
2003-Present
Endocrine Neoplasms of the GI Tract
Lecturer
Johns Hopkins University
School of Medicine (1 hour)
2003-Present
Pediatric Disorders of the GI tract
Lecturer
Johns Hopkins University
School of Medicine (1 hour)
Graduate Program in Pathobiology
2006-Present
Diseases of the endocrine system
Lecturer
Johns Hopkins University
School of Medicine (2 hours)
2006-Present
Introduction to genomics and genetic diseases
Lecturer
Johns Hopkins University
School of Medicine (2 hours)
Fundamentals of Clinical Oncology for Public Health Professionals (School of Public Health)
2005
Controversies in Pancreatic Cancer
Lecturer
Johns Hopkins University
School of Public Health (1 hour)
Attending
Johns Hopkins University
School of Medicine (~150 hours)
Clinical Instruction
Pathology Residency and Fellowship Training
2002-present
GI/Liver Pathology (on-scope training)
CME Instruction
2001
1st Annual Current Topics in GI Pathology
Lecturer
Johns Hopkins University
School of Medicine (1 hour)
2002
2nd Annual Current Topics in GI Pathology
Lecturer
Johns Hopkins University
School of Medicine (1 hour)
2003
3rd Annual Current Topics in GI Pathology
Lecturer
Johns Hopkins University
School of Medicine (1 hour)
2004
4th Annual Current Topics in GI Pathology
Lecturer
Johns Hopkins University
43
Maitra, Anirban
School of Medicine (1 hour)
2005
5h Annual Current Topics in GI Pathology
Lecturer
Johns Hopkins University
School of Medicine (1 hour)
2006
6h Annual Current Topics in GI Pathology
Lecturer
Johns Hopkins University
School of Medicine (1 hour)
2007
7h Annual Current Topics in GI Pathology
Lecturer
Johns Hopkins University
School of Medicine (1 hour)
2008
8th Annual Current Topics in GI Pathology
Lecturer
Johns Hopkins University
School of Medicine (1 hour)
Mentoring
Dates
2002-2003
Name
Hansel, Donna
Degree
M.D.,
Ph.D.
2003-2005
Dhara, Surajit
Ph.D.
2003-2005
Roy, Indrajit
Ph.D.
Present Position
Assistant Professor of
Pathology and Urology,
Cleveland Clinic Lerner
College of Medicine,
Cleveland, Ohio
Faculty Scientist, National
Institute of Biomedical
Genomics, Kolkata, India
Deputy Director,
Biophotonics Division,
Institute for Laser,
Photonics and
Biophotonics, State
University of New York,
Buffalo
Grants/Awards/Degrees
Received
F. Steven Vogel Award,
United States and Canadian
Academy of Pathology for
an outstanding paper by a
resident or fellow
published in an Academy
journal (2006; co-mentored
by Dr. Maitra)
Excellence in Basic
Research, Pathology
Young Investigator's Day,
Johns Hopkins University
(2003)
N/A
N/A
2003-2005
Sui, Guo-Ping
M.D.
Associate at McKinsey &
Company, China
Fellowship Award from the
International Collaborative
Genetics Research Training
Program (ICGRTP), NIH
D43 TW06176
2004
Powell, Eric
M.D.
Research Scientist, Eli
Lilly & Co., IA
N/A
44
Maitra, Anirban
2004-2006
Beaty, Robert
Ph.D.
2004-2006
Fendrich, Volker
M.D.
2005-2009
Alvarez, Hector
M.D.,
Ph.D
2005-2009
Feldmann, Georg
M.D.
2006-2008
Lee, Kwang Hyuck
M.D.,
Ms.C.
2006-2008
Zou, Gang-Ming
M.D.,
Ph.D.
2006-2009
Bisht, Savita
Ph.D.
2007-2008
Habbe, Nils
M.D.
2007-2009
Ryu, Ji Kon
M.D.
Research Associate, Tumor
Biology. Johns Hopkins
University
Faculty in Visceral,
Thoracic and Vascular
Surgery, University
Hospital, Marburg,
Germany
Preparing for clinical
residency (USMLE)
Resident in Oncology,
University of Bonn,
Germany
Assistant Professor of
Internal Medicine,
Samsung Medical Center,
Seoul, Korea
Chief for Section of Stem
Cell Biology, Shanghai
Cancer Institute, Shanghai,
China
Relocated to Bonn,
Germany in 2009
Resident in Visceral,
Thoracic and Vascular
Surgery, University
Hospital Marburg,
Germany
Associate Professor of
Gastroenetrology, Seoul
National University, Seoul,
Korea
N/A
N/A
Ph.D., Catholic University,
Santiago, Chile (2008) –
experimental thesis work
entirely performed in the
Maitra laboratory
Fellowship Award from the
German Academic
Exchange Service (DAAD)
N/A
N/A
N/A
American Pancreatic
Association Annual
Meeting Travel Award
(2008)
N/A
2008
Koorstra, Jan-Bart
PreM.D.
MD/PhD Student at
Utrecht Medical Center,
The Netherlands
Winner of the 2009
Hippocrates Award for
outstanding research by a
medical sudent in the
Netherlands (based on
work performed in the
Maitra laboratory)
2008-2009
Leal Royas, Pamela
Ph.D.
Postdoctoral fellow,
Catholic University of
Chile
N/A
45
Maitra, Anirban
2008-2010
Mizuma, Masamichi
M.D.,
Ph.D.
2008-Present
Gupta, Sonal
Ph.D.
2009-Present
Chenna, Venogopal
Ph.D.
2009-Present
Matthaei, Hanno
M.D.
2009
Ottenhof, Niki
PreM.D.
2009-Present
Pramanik, Dipankar
Ph.D.
2009-2010
Waghray, Meghna
Ph.D.
2009-Present
Hu, Chaoxin
Ph.D.
2010-Present
Dal Molin, Marco
M.D.
2010-present
Roeland de Wilde
PreM.D.
2010-present
Mirte Streppel
PreM.D.
Assistant Professor of
Surgery, Tohoku
University Graduate School
of Medicine, Japan
Postdoctoral fellow, Johns
Hopkins University
Postdoctoral fellow, Johns
Hopkins University
Postdoctoral Fellow, Johns
Hopkins University
MD/PhD Student at
Utrecht Medical Center,
The Netherlands
Postdoctoral Fellow, Johns
Hopkins University
Postdoctoral Fellow, Johns
Hopkins University
Postdoctoral Fellow, Johns
Hopkins University
Postdoctoral Fellow, Johns
Hopkins University
MD/PhD Student at
Utrecht Medical Center,
The Netherlands
MD/PhD Student at
Rotterdam Medical Center,
The Netherlands
N/A
N/A
N/A
Fellowship Award from the
Mildred-Scheel-Stiftung,
Deutsche Krebshilfe,
Germany
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Thesis Committees:
Intramural:
2008
Commitee Member
Joon-Tae Park (Graduate Program in Pathobiology; Thesis Advisors: IeMing Shih & Tian-Li Wang)
Title: Notch signaling in ovarian cancer
2009
Committee Member
David Wang (Graduate Program in Cellular and Molecular Medicine;
Thesis Advisors: Steven Baylin & Neal Watkins)
Title: Hedgehog signaling in esophageal cancer
2010
Committee Member
Sherri-Gae Scott (Graduate Program in Cellular and Molecular Medicine;
Thesis Advisor: Steven Leach)
2010
Committee Member
Kimberly Walter (Graduate Program in Pathobiology; Thesis Advisor:
Michael Goggins)
46
Maitra, Anirban
-
Committee member
Extramural:
2010
Commitee Member
Yolanda Hillocks (Graduate Program in Human Genetics; Thesis Advisor:
Sara Sukumar)
Joseph LaConti (Georgetown University Medical Center; Thesis Advisor:
Anton Wellstein)
Training Grant Participation:
2005-Present
NIH/NCI T32CA067751 Training Program in Pathobiology of Cancer (PI: Gabrielson)
2008- Present
NIH/NCI T32CA130840 Postdoctoral Training Program in Nanotechnology for Cancer Medicine
(PI Wirtz)
2009-Present
NIH/NIDDK R24DK064388 Hopkins Digestive Disease Basic Research Development Core Center
(PI: Donowitz)
Educational Program Building/Leadership
2008-Present
Department of Pathology Residency Research Commitee (This commitee provides individual
mentorship to clinical residents during their training at Johns Hopkins)
CLINICAL ACTIVITIES
Certification:
Fellow, American Board of Pathology (2001)
Licensure
Maryland Board of Physicians
D0057031
Expires 09/2011
Clinical Service Responsibilities:
2002- Present Gastrointestinal Mucosal Biopsy service, Department of Pathology
Attending Physician
Clinical Program Building/Leadership
2008-present Department of Pathology Residency Selection Committee
ORGANIZATIONAL ACTIVITIES
Institutional Administrative Appointments:
10/06
11/07
11/08
11/09
4/10
Co-Director, 6th Annual Current Topics in Gastrointestinal Pathology, Johns Hopkins University
Co-Director, 7th Annual Current Topics in Gastrointestinal Pathology, Johns Hopkins University
Co-Director, 8th Annual Current Topics in Gastrointestinal Pathology, Johns Hopkins University
Co-Director, 9th Annual Current Topics in Gastrointestinal Pathology, Johns Hopkins University
Co-Director, Pathology Young Investigators Day, Johns Hopkins University
47
Maitra, Anirban
Editorial Board Appointments:
2000-2006
2006-2008
2006-Present
2007-Present
2009-Present
Associate Editor, Current Molecular Medicine
Section Editor, Laboratory Investigation
Editor-in-Chief, Current Molecular Medicine
Editorial Board, Pancreatology
Associate Editor, Laboratory Investigation
Journal Peer Review Activities:
2002- Present
Ad hoc reviewer for American Journal of Pathology, American Journal of Surgical Pathology,
British Journal of Cancer, Cancer Cell, Cancer Research, Clinical Cancer Research,
Gastroenterology, Gut, Journal of Clinical Investigation, Nature Medicine, Oncogene,
Proceedings of the National Academy of Sciences, Science Translational Medicine.
Advisory Committees, Review Groups/Study Sections:
1. National Institutes of Health Study Sections:
2005
2006
2006
2007
2007
2008
2008
2008
2009-2012
National Cancer Institute; Special Emphasis Panel on Centers for Cancer\ Nanotechnology
Excellence ZCA1 GRB-S (CCNE), Ad Hoc Reviewer
National Cancer Institute; Oncology Fellowship ZRG1 F09S, Ad Hoc Reviewer
National Cancer Institute; Drug Discovery and Molecular Pharmacology (DMP) study section, Ad
Hoc Reviewer
National Cancer Institute; Basic Mechanisms of Cancer Therapy (BMCT) study section, Ad Hoc
Reviewer
National Cancer Institute; Special Emphasis Panel ZRG1 ONCS 02, Ad Hoc Reviewer
National Cancer Institute; Special Emphasis Panel Cancer Biology and Therapy ZRG1 ONC-U
(92), Ad Hoc Reviewer
National Cancer Institute; Special Emphasis Panel Molecular Tumorigenesis ZRG1 ONC-K (03),
Ad Hoc Reviewer
National Cancer Institute; Special Emphasis Panel ZRG1 ONC-S (03) M, Ad Hoc Reviewer
National Cancer Institute; Tumor Progression and Metastases IRG, Chartered Member
2. Non-federal Granting Agencies
2004-2005
Italian Association for Cancer Research (AIRC), Ad Hoc Reviewer
2005
Irish Research Council for Science, Engineering and Technology (IRCSET) EMBARK Initiative,
Ad Hoc Reviewer
2007-present
Michael Rolfe Foundation for Pancreatic Cancer Research, Scientific Advisory Board Member
2008
AACR-Pancreatic Cancer Action Network (PanCAN); Pilot Grant Awards Review Committee, Ad
Hoc Reviewer
2008-2010
United States and Canadian Academy of Pathology, Member of Gastrointestinal and Liver
Pathology Abstract Review Committee
2009
Italian Association for Cancer Research (AIRC), Ad Hoc Reviewer
2010
External SAB member, P01CA109552 Targets to Therapeutics in Pancreatic Cancer (PI:
Daniel Von Hoff, TGEN)
Professional Societies:
48
Maitra, Anirban
1997-Present
1998-2004
2002-03
2002-Present
2003-Present
Member
Member
Member
Member
Member
United States and Canadian Academy of Pathology
Society for Pediatric Pathology
American Gastroenterological Association
American Society for Investigative Pathology
American Association for Cancer Research
Conference Organizer, Session Chair
2008
2009
Pancreatic cancer symposium, Australian Health and Medical Research Congress, Brisbane,
Australia
Session Chair
Cancer stem cells, American Society for Clinical Oncology Annual Meeting Orlando, FL
Session Chair
Consultantships
2008-Present
Member, Scientific Advisory Board, SignPath Pharma, Inc., Quakerstown, PA
RECOGNITION
Awards and Honors:
1997
Texas Society of Pathologists
John D Rainey Memorial Award
(Awarded for meritorious presentation by a pathologist-in-training at the TSP annual meeting)
1997
Society for Pediatric Pathology
Gordon F. Vawter Award
(Awarded for best presentation by a pathologist-in-training at the SPP annual meeting)
1999
American Society of Cytopathology
Warren R Lang Award
(Awarded for best presentation by a pathologist-in-training at the ASC annual meeting)
2000
Society for Pediatric Pathology
Lotte Strauss Award
(Awarded for best original research publication in the previous year on a topic germane to pediatric
pathology by an individual less than 40 years of age)
2001
Society for Pediatric Pathology
Harry B. Neustein Award
(Awarded for application of new or novel technology to the study of pediatric pathology)
2001
UT Southwestern Medical Center Department of Pathology Best Small Group Teaching Award
2004
United States and Canadian Academy of Pathology Benjamin Castleman Award
(Awarded by the Academy for an outstanding original research paper published in the field of
human pathology in the preceding year)
2006
Maryland Academy of Sciences Maryland Outstanding Young Scientist Award (Allan C. Davis
Medal) (Awarded in recognition of extraordinary contributions to science by a Maryland resident
under 35 years of age)
2008
United States and Canadian Academy of Pathology Ramzi Cotran Young Investigator Award
(Awarded by the Academy to an individual under the age of 45 years who has significantly
contributed to a body of work related to the diagnosis and understanding of human disease)
49
Maitra, Anirban
Invited Lectures:
10/02
Molecular mechanisms involved in PanIN progression towards invasive pancreatic
adenocarcinoma. Annual Meeting of the Japanese Forum for Carcinoma in Situ of the Pancreas,
Nagoya, Japan.
11/02
Molecular genetics of pancreatic intraepithelial neoplasia, Arizona Cancer Center, Tucson,
Arizona.
04/03
Sequencing the human mitochondrion using CustomSeq resequencing microarray, European
Society of Human Genetics Symposium Affymetrix Users Group Meeting, Birmingham, UK.
10/03
Sequencing the human mitochondrion using CustomSeq resequencing microarrays, American
Society of Human Genetics Symposium Affymetrix Users Group Meeting, Los Angeles, California
06/04
Emerging concepts: Pancreatic cancer pathogenesis at “Meet the Professor” Session, American
Society of Clinical Oncology Annual meeting, New Orleans, Louisiana.
07/04
Biliary tract cancer: molecular pathogenesis and cellular targets, International Workshop in
Biliary Tract Cancer, Shanghai, China.
09/04
Pancreatic Intraepithelial Neoplasia, Sidney Kimmel Comprehensive Cancer Center
Translational Research Conference, Johns Hopkins University, Baltimore, Maryland.
03/05
Pancreatic Cancer 2005: Advances and Challenges, 94th Annual Meeting of the United States
Canadian Academy of Pathology Advanced Molecular Pathology Course, San Antonio, Texas
03/05
Pancreatic Intraepithelial Neoplasia, Department of Pathology Grand Rounds, Yale University
School of Medicine, New Haven, Connecticut.
04/05
Towards Effective Management of Pancreatic Cancer: New Concepts in Organ Site
Research, 96th Annual Meeting of the American Association for Cancer Research, Anaheim,
California.
05/05
Molecular Correlates of Pancreatic Intraepithelial Neoplasia, American Gastroenterology
Association’s Digestive Diseases Week, Chicago, Illinois.
06/05
Familial Pancreatic Cancer, Annual Meeting of the Lustgarten Foundation for Pancreatic Cancer
Research, Memorial Sloan Kettering Cancer Center, New York.
08/05
Pathogenesis of Biliary Tract Cancer, Yonsei University, Seoul, South Korea.
08/05
Anatomic Pathology Visiting Professor Lecture Series, The University of Texas Southwestern
Medical Center, Dallas, Texa.
10//05
Monitoring Genomic stability in human embryonic stem cells (Affymetrix Webinar).
01/06
Pancreatic Cancer 2006, Department of Pathology, Northwestern University School of Medicine,
Chicago, Illinois.
50
Maitra, Anirban
03/06
Pancreatic Cancer: Advances and Challenges, Uniformed Services University of the Health
Sciences/United States Military Cancer Institute Joint Symposium, Bethesda
06/06
Novel Molecular Approaches for Early Detection of Pancreatic Cancer, Annual Meeting of the
Lustgarten Foundation for Pancreatic Cancer Research, University of North Carolina, Chapel Hill
09/06
Morphogenesis of Pancreatic Cancer – the role of PanIN lesions, International Meeting of
Cancer of the Pancreas, Ulm, Germany.
11/06
Pancreatic cancer: strategies for early detection and prevention, 2006 AACR Frontiers in
Cancer Prevention and Research Conference, Washington, DC.
02/07
Developmental Signaling Pathways in Pancreatic cancer, Cardinal Bernadin Cancer Center,
Loyola University School of Medicine.
03/07
Developmental Signaling Pathways in Pancreatic cancer, University of California San
Francisco, San Francisco.
05/07
Molecular Pathogenesis of Pancreatic cancer, Digestive Disease Week, Washington DC.
11/07
A functional assay for pancreatic cancer stem cells, American Pancreatic AssociationLustgarten Foundation for Pancreatic Cancer Research Special Symposium on Pancreatic Cancer
Stem Cells, Chicago.
03/08
Pancreatic Cancer 101, Pancreatic Cancer Action Annual Advocacy Day, Washington, DC.
03/08
Pancreatic Cancer 2008, Department of Pathology Grand Rounds at Georgetown University
Medical Center, Washington DC.
04/08
New therapeutic targets for Pancreatic Cancer, Han-Mo Koo Memorial Seminar Series at Van
Andel Research Institute, Grand Rapids, Michigan.
05/08
New Therapeutic Targets for Pancreatic Cancer, Lombardi Cancer Center Visiting Professor
Series, Georgetown University Medical Center, Washington DC.
05/08
New Therapeutic Targets for Pancreatic Cancer at the Pancreatic Cancer Research Team
Annual Meeting, American Society of Clinical Oncology, Chicago IL.
07/08
Pancreatic Cancer 2008: Advances and Challenges, University of Minnesota Masonic Cancer
Center, Minneapolis, MN.
09/08
Cystic Precursor Lesions of Pancreatic Cancer: Primum non nocere, 17th Steering Committee
Meeting of the National Cancer Institute Early Detection Research Network (EDRN), Seattle, WA.
11/08
Pancreatic Cancer Stem Cells, Australian Health and Medical Research Congress, Brisbane,
Australia.
02/09
Nanotechnology applications for pancreatic cancer diagnosis and therapy, Indo-US Science
and Technology Forum on Cancer Nanotechnology, New Delhi, India.
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Maitra, Anirban
04/09
Hedgehog signaling pathway in pancreatic cancer (Basic Science-Clinical Interface Session),
100th Annual Meeting American Association for Cancer Research, Denver, CO.
10/09
Pancreatic Cancer; Comfort Family Visiting Professor Lectureship, Division of Gastroenterology
and Hepatology, Mayo Clinic.
11/09
Pancreatic cancer in the post-genomics era: are we ready to take the road less traveled?
Frank Brooks State of the Art Lecture at the American Pancreatic Association – Japanese
Pancreatic Society 40th Anniversary Meeting, Honolulu, Hawaii.
05/10
Pancreatic Cancer: Advances and Challenges. University of Arkansas at Little Rock Winthrop
Rockefeller Cancer Research Institute Cancer Forum Series, LittleRock, AR
05/10
Emerging therapeutic targets in pancreatic cancer at the 11th Annual Symposium on Biology of
Pancreatic Development, Regeneration and Malignancy, University of Pennsylvania School of
Medicine, Philadelphia, PA
05/10
Cystic precursor lesions of pancreatic cancer at the 22nd Annual Meeting of the Japanese Society
of Hepato-Biliary-Pancreatic Surgery, Sendai, Japan
10/10
Pancreatic Cancer at the Division of Cellular and Gene Therapies, Center for Biologics
Evaluation and Research, United States Food and Drug Administration
52