Preparation, characterization and atomic absorption spectroscopic
determination of some metal complexes of glipizide
Gamal A. Saleha, Samiha A. Husseina, Hassan R. H. Alia, Ahmed I.
Hassanb
a
b
Department of Pharmaceutical Analytical Chemistry, Faculty of
Pharmacy, Assiut University, Assiut 71526, Egypt.
Department of Pharmaceutical Analytical Chemistry, Faculty of
Pharmacy, Al-azhar University (Assiut Branch), Assiut 71524, Egypt.
Abstract
Glipizide is a commonly used sulfonylurea oral hypoglycemic drug. The
present work reports the preparation and characterization of its metal
complexes with cadmium, mercuric, ferric, zinc, cobalt, nickel and
calcium. The existence of these complexes has been confirmed by FTIR
spectroscopy, which revealed that formation of these complexes was in
2:1 stoichiometry of glipizide and each studied metal, respectively. Close
FTIR inspection confirmed the co-ordination of nitrogen and carbonyl
oxygen atom of –SO2NHCONH- moiety of glipizide with the studied
metals. Further, the formed complexes have been analyzed using atomic
absorption spectroscopy. The method was successfully applied for the
indirect determination of glipizide in its dosage form for the first time.