University of Toronto
Cardiovascular Sciences Collaborative Program
ACTIVITY REPORT
1998 – 1999
FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2
Tel: 416/978-0746
Fax: 416/946-5713
E-mail: cv.program@utoronto.ca
Web site: www.library.utoronto.ca/www/cardiosci/index.html
CONTENTS
Collaborating Departments
Executive Committee
Courses Offered
Program Sponsored Activities
- Annual Cardiovascular Scientific Day
- Medtronic Travel Award
- Bigelow Book Prize
- Ontario Student Opportunity Trust Funds (OSOTF) Award
- Lecture Series
- 2nd Annual “Cardiovascular Disease Update”
- Summer Activities
Advertising Material
- World Wide Web
Program Faculty
Program Students
Convocated Students/Follow-up
Student Achievements
Director’s Comments
Publications
- Students
- Faculty
Acknowledgements
The Cardiovascular Sciences Collaborative Program has continued to look to the millennium to
develop student participation and through forged links strengthen the experience of all Program
participants for both faculty and students. By solidifying the Program’s financial base through
interest available from endowments, industry sponsorship, and individual departmental support,
the Program is in a more secure position. It is with excitement and anticipation we look to the
year 2000 as we are now better placed to provide an outstanding value added graduate training
experience to those who wish to specialize in cardiovascular sciences.
The Program office is now consolidated on campus in the FitzGerald Building as we recently
closed the satellite office. Day-to-day functions of the Program are handled by the Program
Director, Dr. C. Wittnich, and the Program Administrator, Victoria Simpson, with the guidance
of the Executive Committee.
Thanks to all of the faculty, students, and participants in our activities for another successful
year!
Dr. Carin Wittnich
COLLABORATING DEPARTMENTS
Faculty:
Medicine
Physical Education and Health
Clinical:
Department of Medicine
Department of Surgery
Department of Anaesthesia
Graduate:
Department of Clinical Biochemistry
Department of Community Health
Department of Exercise Sciences
Department of Pharmacology
Department of Physiology
Department of Rehabilitation Science
Institute of Medical Science
Laboratory Medicine and Pathobiology
Other:
The Centre for Cardiovascular Research
Institute of Biomedical Engineering
EXECUTIVE COMMITTEE
The Executive Committee consists of a representative from each collaborating department as
well as a student representative.
Dr. C. Wittnich (Director)
Dr. M. Plyley (Exercise Science)
Dr. M. Rabinovitch (Lab. Med. Pathobiology)
Dr. D.H. Osmond (Physiology)
Dr. R.D. Weisel (IMS)
Dr. C-C. Liew (CCR)
Dr. R.I. Ogilvie (Pharmacology)
Dr. M. Ojha (IBME)
Dr. D. Cheng (Anaesthesia)
Dr. S. Thomas (Rehabilitation Science)
Dr. Andrew Campbell (Student Representative)
COURSES OFFERED
EXS5508H
MSC3060H*
MSC3061H*
LMP1015H
PCL1006Y
PSL1029H
PSL1038H
PSL1060H
LMP1407H
LMP1503H
LMP1504H
BME1448H
JEB1365H
JTC1331H
Cardiovascular Disease and Exercise (Exercise Science)
Advanced Topics in Cardiovascular Sciences I (IMS)
Advanced Topics in Cardiovascular Sciences II (IMS)
Vascular Pathobiology (Lab. Med. Pathobiology)
Cardiovascular Pharmacology (Pharmacology)
Advanced Course in Cardiovascular Regulation (Physiology)
Volume, Electrolyte and Pressure Regulation in Body Fluid Compartments
(Physiology)
Developmental Cardiovascular Physiology (Physiology)
From Bench to Bedside: Design, Measurement, and Analysis for Clinical
Investigators (Lab. Med. Pathobiology)
Signal Transduction Pathways in Normal and Diseased Tissue (Lab. Med.
Pathobiology)
Biochemistry, Molecular Biology of Cardiovascular Diseases (Lab. Med.
Pathobiology)
Cardiovascular Fluid Mechanics (IBME)
Ultrasound: Theory and Applications in Biology and Medicine (IBME)
Biomaterials Science (IBME)
* Core Courses for PhD Trainees
PROGRAM SPONSORED ACTIVITIES
Annual Cardiovascular Scientific Day - May 20, 1999
The Annual Scientific Day, hosted by the Cardiovascular Sciences Collaborative Program,
University of Toronto and the Centre for Cardiovascular Research (CCR), is organized to bring
together faculty and students interested in cardiovascular sciences. The aim is to provide an
update in the frontiers of cardiovascular science and each symposium focuses on either clinical or
basic science research. Attendees are encouraged to actively participate, either in the form of a
poster presentation or oral discussion, promoting cross-fertilization of ideas and assisting
research direction within our own cardiovascular community.
The scientific day was held at the Granite Club where over 350 registrants enjoyed a pleasant day
of camaraderie, excellent science, and good food. This year the focus was on “Cardiovascular
Care at the Millennium”. A central featured symposium exploring the evaluation of this care
consisted of a number of speakers both local and invited. Dr. David Alter, Department of
Medicine, ICES and Cardiology, spoke on “Trends and Variations in Cardiovascular Disease in
Ontario-Highlights from the Cardiovascular Atlas”. Dr. Geoffrey Anderson, Associate
Professor, Health Administration, University of Toronto, discussed “Research on Public Report
Cards: Good Science or Good Politics?”. Dr. Jacques LeLorier, Professor, Depts of Medicine
and Pharmacology, University of Montreal was the Annual Isadore E. Smith Lecturer, hosted by
the CCR. He discussed “The Role of Patients and Healthcare Professionals in the Use and
Misuse of Cardiovascular Drugs”. This session was followed by a refreshment break and then
the focus shifted to therapeutic advances at the millennium. Topics covered included
presentations on “CPAP for Advanced Heart Failure” (Dr. T.D. Bradley), “Off-pump Bypass”
(Dr. Y. Leclerc), “Cell-based Research in Cardiac Xenotransplantation” (Dr. J.G. Coles) and
“Gene Therapy for Paediatric Congenital and Adult Cardiovascular Disease” (Dr. M.
Rabinovitch). After a very pleasant lunch, the afternoon began with Poster Presentations by our
graduate and postdoctoral trainees. This was followed by an afternoon session which covered the
“Approaches to Atherosclerosis at the Millennium”. This was highlighted by presentations on
“Genetic Dissection of Atherosclerosis” (Dr. R.A. Hegele-Annual Guest Speaker),
“Homocysteine and Atherosclerosis” (Dr. J.D. Spence-Annual Guest Speaker), “Inflammatory
Heart disease and Autoimmunity: Chlamydia and Atherosclerosis” (Dr. J. Penninger), and
“Anti-Atherosclerotic Properties of Wine” (Dr. D.M. Goldberg).
There were 33 abstracts submitted for the poster session. A panel of judges preselected six
poster finalists who were also asked to give a short oral presentation during a poster walkabout.
An additional hour of poster viewing was available during the breaks and over lunch. These
posters highlighted our cardiovascular trainees in their particular area of interest. Poster prizes,
in the form of textbooks, were again generously provided by Lippincott-Ravin Publishers.
1st Prize 2nd Prize (Tied)
2nd Prize (Tied)
A.I.M. Campbell ~~ Angiogenic therapy for pulmonary hypertension (Supervisor:
Dr. D.J. Stewart)
K.S. Bandali ~~ Neonatal hemodynamic & metabolic responses to hyperoxia
(Supervisor: Dr. C. Wittnich)
P.W.M. Fedak ~~ Predictors of risk for coronary bypass with severe LV
dysfunction (Supervisor: Dr. R.D. Weisel)
Continuing medical education credits were issued for this meeting; continuing the high quality of
scientific content (6.5 hours of category 1 credit toward the AMA Physicians Recognition Award
and 8.45 MOCOMP credits for the Royal College of Physicians and Surgeons of Canada).
My thanks are extended, once again, to industry for their continued financial support and
generousity which is so essential to the success of this meeting. Major sponsorship included
Hoechst Marion Roussel Canada, Key Pharmaceuticals, and Merck Frosst Canada Inc. Because
of their support, we were able, once again, to provide an open registration and complimentary
luncheon.
Students who completed the Cardiovascular Sciences Collaborative Program were recognized at
the Awards ceremony and included Newsha Azizi, MSc (Supervisor: Dr. U. Ackermann),
Warren Ball, MSc (Supervisor: Dr. R-K. Li, Andrea Burry, MSc (Supervisor: Dr. M.
Rabinovitch), Hani Najm, MSc (Supervisor: Dr. C. Wittnich), and Catherine Mason, PhD
(Supervisor: Dr. M. Rabinovitch).
The Annual Cardiovascular Scientific Day continues to be the highlight of our academic year!
Medtronic Travel Award
Two competitions were held (spring and fall) for the Medtronic Travel Award. This award,
established in 1995, helps to defray costs of travel for Program students presenting their research
work at recognized scientific meetings. Students supported by this award this academic year
were:
Fall 1998:
Rohan Shahani: Myocardial Dysfunction following Repair of Ruptured Abdominal Aortic
Aneurysms. 71st Scientific Sessions of the American Heart Association, November 1998
(Supervisor: Dr. Thomas Lindsay, IMS).
Shona Torrance: Ischemic Time in Immature Hearts: Duration Does Not Predict All Aspects of
Functional Recovery. Annual Meeting of the Canadian Cardiovascular Society, October 1998
(Supervisor: Dr. C. Wittnich, IMS).
Jack Wallen: Does Gender Affect Metabolic Potential in Hypertrophied Hearts? Annual Meeting
of the Canadian Cardiovascular Society, October 1998 (Supervisor: Dr. C. Wittnich, Physiology)
Note: No applications were received for the Spring 1999 competition.
Bigelow Book Prize
The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts”
and “Mysterious Heparin”. This prize was established in 1995 by the Cardiovascular Sciences
Collaborative Program to recognize and honour a pioneer clinician and scientist in the field of
cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow -curiosity, drive, and scientific integrity. The award is given in every year that a qualified student
is identified. Qualifications include sustained academic scientific excellence, innovative
experimental approaches, original discoveries and good scientific productivity. Some weight is
given to work that has recognizable clinical relevance, especially that which promises to improve
patient care.
1995 - Dr. John S. Ikonomidis
1996 - Ms. Shona M. Torrance
1997 - Dr. Vivek Rao
1998 - Dr. Bryce Cowan
1999 – Dr. Gideon Cohen
Ontario Student Opportunity Trust Funds (OSOTF) Award
The OSOTF award refers to a class of awards which have resulted from Ontario government’s
“matching” program. Under the program every dollar of donation received for student assistance
has been matched by the government as well as the university on a dollar-for-dollar basis. The
Cardiovascular Sciences Collaborative Program participates in this program. There are two
major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate
financial need. However, the Program has additional eligibility criteria, including excellence in
science and academic performance, that must be adhered to. One competition will be held per
academic year, except for the inaugural competition year where two competitions were held.
The applications are handled centrally through the Faculty of Medicine’s, Research Office.
Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee;
chaired by Dr. D. Cheng. Committee recommendations are then forwarded to the OSOTF
Awards Committee (Faculty of Medicine) where the final decision is made. Of this years eligible
submissions, all were deemed meritorious and the awards were allocated equitably to the winners
as follows:
Fall 1998 Competition
Karim Bandali, PhD, Dept. of Physiology
Jack Wallen, PhD, Dept. of Physiology
Spring 1999 Competition
Karim Bandali, PhD, Dept. of Physiology
Jack Wallen, PhD, Dept. of Physiology
Cathy Boscarino, MSc, Dept. of Physiology
Lecture Series
For this academic year the lecture series was focused in two main areas: Heart Function and
Vascular. A number of interesting speakers, once again, contributed their time and knowledge.
Both these areas were covered from the perspective of whole body and organ to the molecular
level including genetics, with a particular emphasis on bridging basic science and clinical
approaches to these areas.
2nd Annual “Cardiovascular Disease Update”
The 2nd Annual Cardiovascular Disease Update was successfully held on February 27, 1999 at
the Weston Prince Hotel, Toronto. This annual CME event was made possible by the generous
sponsorship of Bristol-Myers Squibb. The purpose of this half day event is to provide clinical
insight into the diagnosis and treatment of current cardiovascular disease from a bench-tobedside perspective. This year the focus was on issues relating to women and heart disease,
hypertension and drug therapies. Each session was accompanied by audience discussion which
continued informally during the buffet luncheon. The meeting was accredited for 4 Mainpro-MI
credits and 5.2 MOCOMP credits and was attended by 121 Family Physicians and Internists from
across Toronto. The speakers and topics were:
Dr. Beth Abramson, Lecturer, Dept. of Medicine, University of Toronto
Cardiologist and Director, Women’s Cardiovascular Health, St. Michael’s Hospital
“Diagnosis of Chest Pain in Women: Looks May Be Deceiving”
Dr. Paul Oh, Lecturer, Clinical Pharmacology, University of Toronto
Clinic Director, Cardiovascular Assessment & Rick Evaluation, Sunnybrook Health Science
Centre
“Caveats & Pearls – What the Family Practitioner Needs to Know When Following the Post-MI,
CHF, or Angina Patient”
Dr. David Mendelssohn, Associate Professor of Medicine, University of Toronto
Nephrologist and Director of Peritoneal Dialysis, St. Michael’s Hospital
“Diabetes and Hypertension: A Potpourri of New Information”
Dr. Jules Yt Lam, Associate Professor of Medicine, University of Montreal
Cardiologist, Montreal Heart Institute
“Differentiation of the Statins”
Summer Activities
The Collaborative Program, along with the Division of Cardiac Surgery, Department of Surgery,
ran another very successful summer program. Applicants included undergraduate and medical
school students from the University of Toronto as well as other universities. The Collaborative
Program provided a number of summer scholarships to help students who were unable to procure
funding. Over the course of the summer, seminars were presented by graduate students currently
enrolled in the Collaborative Program and covered a range of topics with both clinical and basic
science relevance. As well, the summer students were given the opportunity to present their
summer work. An “end-of-summer” luncheon is held for both faculty and students.
This highly successful program is enjoyed by all who participate.
ADVERTISING MATERIAL
World Wide Web
The Cardiovascular Sciences Collaborative Program continues to maintain its own web site
under the Faculty of Medicine. This web site is updated regularly and is continually undergoing
expansion. Please check out our site at www.library.utoronto.ca/www/cardiosci/index.html to
learn more about cardiovascular sciences. The site is updated at faculty renewal and whenever
relevant changes occur. Links continue to be built with other relevant cardiovascular sites.
Collaborating departments are encouraged to provide hypertext links to the Collaborative
Program on their web site.
Other material that continues to give the Program exposure includes the brochure, the Scientific
Day pamphlets and posters, various industry sponsored seminars, and the Lecture Series notices
posted on campus. Collaborating departments also display and distribute the Program brochure.
PROGRAM FACULTY
Faculty are divided into 3 categories (Full, Associate, and Affiliate) depending on their SGS
status.
FULL:
U. Ackermann, L. Adamson, P. Backx, C.E. Bayliss, D. Bradley, F. Coceani, J.
Coles, J. Edelson, C.R. Ethier, J.S. Floras, C. Forrest, S. Fremes, J.M. Goodman,
A.I. Gotlieb, K.W. Johnston, P.G. Kalman, F. Keeley, B.L. Langille, H. Lenskyj,
G.F. Lewis, C-C. Liew, P. Liu, P. McLaughlin, D.A.G. Mickle, L.
Mickleborough, R.I. Ogilvie, M. Ojha, D.H. Osmond, T. Parker, M.J. Plyley, M.
Rabinovitch, M. Sefton, I. Sherman, A.S. Slutsky, M.J. Sole, G. Steiner, D.E.
Stewart, D.J. Stewart, S.G. Thomas, P. Walker, R.D. Weisel, G. Wilson, C.
Wittnich, T-W. Wu, E.L. Yeo
ASSOCIATE: M. Bendeck, D. Brooks, E. Conway, P. Dorian, L.S. Goodman, J. Irvine, T.
Lindsay, M. Locke, J. Parker, N.A. Shaikh, R. Wald
AFFILIATE: R.J. Burns, J. Butany, D. Cheng, D. Courtman, C.M. Feindel, J. Fisher, R-K. Li,
R. McLean, P. Murphy, L. Schwartz
We would like to wish Dr. E. Conway all the best in his new position in Belgium. As well, best
wishes to Dr. F. Coceani whose base of operation is now in Italy but he has maintained his ties
with the University of Toronto.
Our thoughts and prayers go out to the family of Dr. Adelman whose life’s journey ended this
past May.
PROGRAM STUDENTS
Student
Karim Bandali
Michael Borger
Cathy Boscarino
Andrew Campbell
Gideon Cohen
Ian Copland
Kyle Cowan
Sonia Katyal
Negin Liaghati-Nasseri
Vaska Micevski
Stephen Milone
Stacy O’Blenes
Rohan Shahani
Shona Torrance
Dimitra Trambakoulos
Jack Wallen
Mohammed Warsi
Supervisor
C. Wittnich
R. Weisel
C. Wittnich
D. Stewart
R.D. Weisel
L. Adamson
M. Rabinovitch
S. Thomas
S. Fremes
D. Stewart
J. Parker
M. Rabinovitch
T. Lindsay
C. Wittnich
D. Osmond
C. Wittnich
P. Liu
Degree
PhD
PhD
MSc
PhD
PhD
MSc
PhD
MSc
MSc
PhD
MSc
MSc
MSc
PhD
MSc
PhD
MSc
Department
Physiology
IMS
Physiology
IMS
IMS
Physiology
Pathology
Rehab Med
IMS
IMS
Pharmacology
Pathology
IMS
IMS
Physiology
Physiology
IMS
CONVOCATED STUDENTS/FOLLOW-UP
Newsha Azizi, MSc, Dept. of Physiology (Supervisor, Dr. U. Ackermann) has continued with her
graduate training as a PhD student.
Warren Ball, MSc, Institute of Medical Science (Supervisor: Dr. R-K. Li) has been accepted into
medical school.
Andrea Burry, MSc, Laboratory Medicine and Pathobiology (Supervisor: Dr. M. Rabinovitch)
has been accepted into medical school.
Hani Najm, MSc, Institute of Medical Science (Supervisor: Dr. C. Wittnich) has accepted a
position of Associate Professor in Surgery at the King Saudi University.
Catherine Mason, PhD, Laboratory Medicine and Pathobiology (Supervisor: Dr. M. Rabinovitch)
has returned to medical school at the University of Toronto.
STUDENT ACHIEVEMENTS
Karim Bandali
Ontario Student Opportunity Trust Fund (OSOTF) Award
The Centre for Cardiovascular Research Scientific Day Featured
Poster/Winner
Michael Borger
Edward Christie Stevens Fellowship, University of Toronto
Graham Campbell Fellowship, University of Toronto
Merit Scholarship, Institute of Medical Science, University of Toronto
PSI Resident Research Award
J.C. Laidlaw Award of Excellence, Institute of Medical Science,
University of Toronto
First Prize, Terrence Donnelly Canadian Cardiac Surgery Resident
Research Day
Catherine Boscarino John Hepburn Award, Dept. of Physiology, University of Toronto
University of Toronto Fellowship, Dept. of Physiology
Pharmaceutical Manufacturers Assoc. of Canada/Medical Research
Council (MRC) Summer Scholarship
Gideon Cohen
Edward Christie Stevens Fellowship, University of Toronto
Harrison Teaching Award, Dept. of Surgery, Sunnybrook Health Science
Centre
Kyle Cowan
Tuition Scholarship, Hospital for Sick Children
Emmanuel Farber Award, Dept. of Laboratory Medicine and Pathobiology
Research Day
Research Traineeship, Heart and Stroke Foundation of Canada(declined)
Doctoral Research Award, Medical Research Council of Canada and K.M.
Hunter Awardee Distinction
Ontario Graduate Scholarship(declined)
Doctoral Fellowship, University of Toronto Open
Dutkevich Research Travel Award
Worthington Award for Travel
Bio-Rad Awardee
Robert Disenhouse Cardiac Science Award
Featured Poster, Cardiovascular Sciences Collaborative Program Research
Symposium
Park Davis Award
Negin LiaghatiUniversity of Toronto Open Scholarship
Nasseri
Vaska Micevski
Stacy O’Blenes
Rohan Shahani
Shona Torrance
Jack Wallen
Mohammed Warsi
Nursing Research Fellowship (PhD), Heart and Stroke Foundation of
Canada
North American Menopause Society/Wyeth-Ayerst Nurse Practitioner
The Terrence Donnelly Cardiac Resident Research Day Wilfred Bigelow
Prize
First Prize, Surgical Services Basic Science Research Competition,
Hospital for Sick Children
Second Prize, Resident/Graduate Student Oral Presentation Seminar,
University of Toronto Trauma Research Day
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
IMPRA/BARD Annual Research Award, Canadian Society of Vascular
Surgeons
Research Fellowship, Ontario Ministry of Health
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Teaching Award, Dept. of Physiology, University of Toronto
Ontario Student Opportunity Trust Funds (OSOTF) Award, University of
Toronto
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Natural Sciences and Engineering Research Council of Canada
Postgraduate Scholarship
Ontario Graduate Scholarship in Science and Technology
Pfizer Award, Eastern Student Research Forum, University of Miami
University of Toronto Open Scholarship
DIRECTOR’S COMMENTS:
In its’ seventh year, the Cardiovascular Sciences Collaborative Program (CSCP) continues to
grow and evolve. During this academic year we had our 7-Year OCGS review which went
resoundingly well, and resulted in a renewal mandate. The CSCP also continues to develop new
liaisons with departments expressing an interest in cardiovascular sciences. Specifically, the
Department of Rehabilitation Science was welcomed to the program.
The CSCP also came to a crossroads this year. On the one hand there was the successful OCGS
review endorsing our effort. On the other hand it became clear we had reached the maximum
capacity of what the Program could accomplish with existing financial and personnel resources.
For the Program to continue to grow, a fully committed administrative individual, focused on the
initiatives of the Program, is critical. To secure this, a stable financial infrastructure is needed to
fund this individual. All activities depend on this basic administrative need which could no
longer be met without a fully designated individual to handle the day-to-day administration.
After lengthy negotiations with a number of parties this issue was addressed.
The following graph represents the enrolment figures. It can be seen that during the current
academic year we had 13 Masters and 9 PhD trainees active in the program. There was a
significant number of our trainees who completed and convocated which, this year for the first
time, exceeded recruitments. With the Program’s resounding endorsement by the SGS and
OCGS, it is clear our focus needs to be student recruitment. To date, no targeted efforts have
been made but we have relied on word of mouth and student satisfaction. This approach, as can
be seen from previous years figures, has been quite successful – resulting over the years in a 4fold increase enrolment. However, the time has come to expand our base and share the potential
of this value added experience with all students through a more aggressive information and
recruiting campaign. Up until and including this year, this was not possible as the Program did
not have a fully committed administrative individual with the time to launch and maintain such
an effort. With this issue reaching a potential resolution, we are now in a position to initiate a
student recruitment drive.
24
20
16
MSc
12
PhD
8
Total
4
0
1992
1993
1994
1995
1996
1997
1998
I continue to meet with the students on an annual basis to ensure continued satisfaction with the
program. From these interviews it was decided to expand the student representation on the
Executive Committee to two (a junior student who has recently started their training and a senior
student). These students will also organize the various student activities for the Program. The
postgraduate follow-up illustrated that the graduates of this past year have gone on to pursue
either academic or research careers. (see Convocated section of Report). As part of the tradition,
bound copies of each graduating students' thesis is kept in the program office.
The CSCP awards programs helped support a number of our trainees. The Medtronic Travel
Award monies made it possible for a number of students to attend scientific meetings and present
their work. As well, the OSOTF bursary monies provided much needed financial relief to a
number of deserving students in the Collaborative Program. These funds will be available on an
annual basis to help those with demonstrated academic and research excellence that are in
financial need. Corporate sponsors such as Bristol-Myers-Squibb and Merck Frosst Canada
continue to be recognised for their outstanding annual support of graduate education in the
cardiovascular sciences area at the University of Toronto.
The Bigelow Book Prize is awarded in recognition of an outstanding graduate student in the
program and is the most prestigious student award given annually. Apart from the annual
luncheon, a plaque is now planned to commemorate this annual event.
Due to the popularity of course MSC 3060/3061, it has been redesigned into 4 modules. These
new modules will be submitted to the SGS for approval which will create new course
designations. Thus, once approved, there will be 4 courses on advanced topics in cardiovascular
sciences for our trainees to select from: MSC3060 - Cellular and Molecular Mechanisms,
MSC3061 - Hormones & the Cardiovascular System, MSC3062 - Heart Function, MSC3063 Vascular. Continued frequent review of these courses will occur to ensure that current
technologies and research foci, that are leading edge, are represented. This is critical if they are
to serve as our flagship courses for our trainees.
The second annual CV Update was again jointly run with the generous support of Bristol Myers
Squibb. This half-day event provided a clinical update and insights to interested trainees,
specialists and general practitioners in the cardiovascular field. Each year a different focus will
be highlighted (see appropriate section in report)
We look forward to working with the newly created Heart & Stroke/Richard Lewar Centre of
Excellence (HSRLCE) at the University of Toronto. The Heart & Stroke Foundation of Ontario
and the family of Richard Lewar jointly donated $13 million to establish this cardiovascular
Centre. The purpose of this Centre is to bring cutting edge cardiovascular research together at
the University and become an international leader of cardiovascular research. A search was
conducted and Dr. Peter Liu was established as Director. The Centre’s mandate includes
research in cardiovascular disease, focusing on the prevention and cure of atherosclerosis, heart
failure and congenital heart disease. There will also be a transgenic physiology core facility at
the FitzGerald Bldg. With the Collaborative Program’s role in education and the Centre’s role in
research, hopefully we can take advantage of these strengths by avoiding duplication and
providing an outstanding second-to-none cardiovascular initiative. This relationship will be
further explored in the upcoming year.
For the 1999-2000 academic year, we plan to continue our current activities and pursue the
following priorities:
1.
2.
3.
4.
5.
Firm up a 5-year plan for the program.
Actively recruit students to the program.
Create a Student Guidebook with course listings to help selection.
Hold the first Student Research Day, February 2000.
Target clinical residents doing 1-2 years of research for recruitment into formal graduate
program where appropriate.
6. Further develop CME programs.
7. Further secure infrastructure support via endowments.
PUBLICATIONS – STUDENTS
Borger MA, Buth KJ, Rao V, Bozinovski J, Liaghati-Nasseri N…Fremes SE: Multiple arterial
grafts: Radial versus right internal thoracic arteries. Circulation, 1998;98:II7-II14.
Borger MA, Peniston CM, Weisel RD, Ivanov J, Rao V, Cohen G, Feindel CM, David TE:
Decreasing incidence of stroke during valvular surgery. Circulation, 1998;98:II137-II143.
Borger MA, Weisel RD: Calcium channel blockers in myocardial and cerebral ischemia: A
clinician’s review from bench to bedside. Can J Cardiol, 1999;15:333-340.
Christakis GT…Fremes SE, Rao V, Cohen G, Borger MA, Panagiotopoulous KP, Weisel RD:
Inaccurate and misleading valve sizing: Proposed standards for valve size nomenclature. Ann
Thorac Surg, 1998;66:1198-1203.
Cohen G, Fremes SE, Feder-Elituv R, et al: A phase II randomized trial of adenosine
cardioplegia. Circulation, 1998;98:II225-II233.
Cohen G, Shirai T, Weisel RD, Rao V…Borger MA, Li R-K, Mickle DAG: Optimal
myocardial preconditioning in a human model of ischemia and reperfusion. Circulation,
1998;98:II184-II196.
Cowan KN, Jones PL, Rabinovitch M: Regression of hypertrophied rat pulmonary arteries in
organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and
smooth muscle cell apoptosis. Circ Res, 1999;84:1223-1233.
Mason C, Bigras J, O’Blenes SB… Rabinovitch M: Gene transfer in utero biologically
engineers a patent ductus arteriosus in lambs by arresting fibronectin-dependent neointimal
formation. Nature Med, 1999;5:176-182.
Micevski V: Myocarditis: The use of molecular technology for the detection of enteroviral
ribonucleic acid in myocarditis. J Cardiovasc Nurs, 1999;13(3):78-90.
O’Blenes SB, Ross DB, Nanton MA, Murphy DA: Atrioventricular septal defect with Tetralogy
of Fallot: Results of surgical correction. Ann Thorac Surg, 1998;66:2078-2084.
Rao V, Komeda M, Weisel RD, Cohen G, Borger MA, David TE: Should the pericardium be
closed routinely after heart surgery? Ann Thorac Surg, 1999;67:484-488.
Rao V, Merante F, Weisel RD, Shirai T, Ikonomidis JS, Cohen G, et al: Insulin stimulates
pyruvate dehydrogenase and protects human ventricular myocytes from simulated ischemia. J
Thorac Cardiovasc Surg, 1998;116:485-494.
Rao V…Fremes SE, Bhatnagar G, Cohen G, Borger MA, Abouzahr L, Goldman BS: A novel
comparison of stentless versus stented valves in the small aortic root. J Thorac Cardiovasc Surg,
1999;117:431-438.
PUBLICATIONS – FACULTY
Abramson BL, Ando S, Notarius CF, Rongen GA, Floras JS: Effect of atrial natriuretic peptide
on muscle sympathetic activity and its reflex control in human heart failure. Circulation
1999;99:1810-1815.
Anderson JL…and the AVID Investigators (P. Dorian-Investigator): Design and results of the
antiarrhythmics vs implantable defibrillators (AVID) registry. Circulation 1999;99:1692-1699.
Andrews TC, Parker JD, et al: Effects of therapy with nifedipine GITS or atenolol on mental
stress-induced ischemic left ventricular dysfunction. J Am Coll Card 1998;32:1680-1686.
Ariel AP, Furlott HG, Chapman KR, Slutsky AS, Webster P, Zamel N, Tarlo SM: Effect of high
dose inhaled acetic acid on airway responsiveness in Fisher rats. Can Resp J 1998;5(5):349-354.
Arthur HM, Garfinkel PE, Irvine J: Development and testing of a new hostility scale. Can J
Cardiol 1999;15:539-544.
Asokumar B, Cheng DCH, et al: Pharmacokinetics of doxacurium chloride during
normothermic and hypothermic cardiopulmonary bypass surgery. Can J Anaesth 1998;45:515520.
Azevedo ER, Newton GE, Parker JD: Cardiac and systemic sympathetic activity in response to
clonidine in human heart failure. J Am Coll Card 1999;33:186-191.
Azevedo ER, Parker JD: Parasympathetic control of cardiac sympathetic activity. Normal
ventricular function versus congestive heart failure. Circulation 1999;100:274-279.
Babensee JE, Cornelius RM, Brash JL, Sefton MV: Immunoblot analysis of proteins associated
with HEMA-MMA microcapsules: Human serum proteins in vitro and rat proteins following
implantation. Biomaterials 1998;19:839-849.
Baker B, O’Kelly B, Szala JP, Katic M, McKessock D, Ogilvie RI, Basinski A, Tobe SW:
Determinants of left ventricular mass in early hypertension. Am J Hyperten 1998;11:1248-1251.
Ball AMM, Sole MJ: Oxidative stress and the pathogenesis of heart failure. Cardiol Clinics
1998;16(4):665-675.
Ballyk PD, Walsh C, Butany J, Ojha M: Compliance mismatch may promote artery/graft
intimal hyperplasia by altering suture-line stresses. J Biomechanics 1998;31:229-237.
Bandali KS, Ackermann U: Are prostaglandins involved in ANP mechanisms of cardiovascular
control? Can J Physiol Pharmacol 1999;77:211-215.
Bayer IM, Adamson SL, Langille BL: Atrophic remodeling of the artery-cuffed artery.
Arteriosclerosis, Thrombosis and Vasc Biol 1999;19:1499-1505.
Bayliss CE, Ackermann U: Edith. Structure/Function, Case 1. Copyrighted, UofT Fac. Med. 41
pages, 1998.
Bayliss CE, Cormack DH, Baker RR: Week 11 Syllabus. Structure/Function. Copyrighted,
UofT Fac. Med. 107 pages, 1998.
Bayliss CE, Cormack DH, Baker RR: Week 12 Syllabus. Structure/Function. Copyrighted,
UofT Fac. Med. 83 pages, 1998.
Bayliss CE, Cormack DH, Baker RR: Week 13 Syllabus. Structure/Function. Copyrighted,
UofT Fac. Med. 84 pages, 1998.
Bayliss CE, Cormack DH, Baker RR: Week 14 Syllabus. Structure/Function. Copyrighted, 46
pages, 1998.
Bayliss CE, Goldlist BJ, Senn JS: Mrs. Lively. Structure/Function, Case 2. Copyrighted, UofT
Fac. Med. 50 pages, 1998.
Bayliss CE, Goode RC, Duffin J, Senn JS: Bart Giamatti. Structure/Function, Case 3.
Copyrighted, UofT Fac. Med. 42 pages, 1998.
Bhatnagar G, Fremes SE, Christakis GT, Goldman BS: Early results using an ePTFE membrane
for pericardial closure following coronary bypass grafting. J Card Surg 1998;13:190-193.
Borger MA, Cohen G, Buth KJ, Rao V, Bozinovski J, Liaghati-Nasseir N...Fremes SE: Multiple
arterial grafts: Radial versus right internal thoracic arteries. Circulation 1998;98:7-14.
Borger MA, Ivanov J, Weisel RD, Peniston CM, Rambaldini G, Cohen G, Rao V, Feindel C,
David TE: Decreased incidence of stroke during valvular surgery. Circ 1998;98(SuppII):137143.
Borger MA, Weisel RD: Calcium channel blockers in myocardial and cerebral ischemia: A
clinician’s review from bench to bedside. Can J Cardiol 1999;15:333-340.
Borges A, Tsushima RG, Backx PH: Antibodies against Tityus discrepens venom do not abolish
the effects of Tityus serrulatus venom on the rat sodium and potassium channels. Toxicon
1999;37(6):867-881.
Bourassa MG…Schwartz L, et al: Is a strategy of intended incomplete PTCA revascularization
acceptable in patients who are candidates for CABG? The Bypass Angioplasty Revascularization
Investigation (BARI). J Am Coll Cardiol 1999;33:1627-1636.
Boutitie F…Dorian P, Frangin G, and the EMIAT & CAMIAT Investigators: Amiodarone
interaction with -blockers: Analysis of the merged EMIAT (European Myocardial Infarct
Amiodarone Trial) and CAMIAT (Canadian Amiodarone Myocardial Infarction Trial) databases.
Circulation 1999;99:2268-2275.
Boylan JF, Katz J, Kavanagh BP, Klinck JR, Cheng DCH, DeMajo WC, Walker PM, Johnston
KW, Sandler AN: Epidural bupivacaine-morphine analgesia versus patient controlled analgesia
following abdominal aortic surgery. Anesthesiology 1998;89:585-593.
Bradley TD, Young T, Strohl KP: American Thoracic Society/American Sleep Disorders
Assocation Statement on Health Outcomes Research in Sleep Apnea. Am J Respir Crit Care Med
1998;157:335-341.
Brenner JKM, Thomas S, Shephard RJ: Autonomic regulation of the circulation during exercise
and heat exposure. Inferences from heart rate variability. Sports Med 1998;26(2):85-99.
Brooks D, Horner RL, Floras JS, et al: Baroreflex control of heart rate in a canine model of
obstructive sleep apnea. Am J Resp Crit Care Med 1999;159:1293-1297.
Byrick RJ, Mullen JB, Murphy PM, Kay CJ, Stewart TE, Edelist G: Inhaled nitric oxide does
not alter pulmonary or cardiac effects of fat embolism in dogs after cemented arthroplasty. Can J
Anaes 1999;46(6):605-612.
Caldarone CA, Najm H, Kadletz M, Smallhorn JF, Freedom RM, Williams WG, Coles JG:
Surgical management of total anomalous pulmonary venous drainage: Impact of coexisting
cardiac anomalies. Ann Thorac Surg 1998;66:1521-1526.
Caldarone CA, Najm HK, Kadletz M, Smallhorn JF, Fredom RM, Williams WG, Coles JG:
Relentless pulmonary vein stenosis after repair of total anomalous pulmonary venous drainage.
Ann Thorac Surg 1998;66:1514-1520.
Campioni E, Nobrega JN, Sefton MV: HEMA-MMA microcapsule implants in
hemiparkinsonian rat brain: Biocompatibility assessment using [3H]PK11195 as a marker for
gliosis. Biomaterials 1998;19:829-837.
Caramori PRA, Adelman AG, Azevedo ER, Newton GE, Parker AB, Parker JD: Therapy with
nitroglycerin increases coronary vasoconstriction in response to acetylcholine. J Am Coll Card
1998;32:1969-1974.
Case P, Lemieux S, Kennedy SH, Lewis GF: Elevated plasma lipids in patients with binge
eating disorder are found only in those who are anorexic. Int J Eating Disorders 1999;25(2):187193.
Cassivi SD, Liu M, Boehler A, Tanswell AK, Slutsky AS, Keshavjee S, Todd TRJ: Transgene
expression after adenovirus mediated retransfection of rat lungs is increased and prolonged by
transplant immunosuppression. J Thorac Cardiovasc Surg 1999;117(1):1-8.
Chan KK, Tsui SKW, Lee SM, Luk SC, Liew CC, Fung KP, Waye M, Lee CY: Molecular
cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in
human heart. Gene 1998;210:345-350.
Chan-Yeung M, McClean PA, Sandell PR, Slutsky AS, Zamel N: Sensitization to cat without
exposure to cats. Clin Exper Allergy 1999;29(6):762-765.
Chen X, Hassan MO, Jones JV, Sleight P, Floras JS: Baroreflex sensitivity and the blood
pressure response to -blockade. J Human Hypertension 1999;13:185-190.
Cheng DCH: Fast track cardiac surgery pathways; early extubation, process of care, and cost
containment. Anesthesiology 1998;88:1429-1433.
Cheng DCH: Impact of early tracheal extubation on hospital discharge. J Cardiothorac Vasc
Anesth 1998;12(Suppl.2):35-40.
Chiamvimonvat V, Newman D, Tang A, Green M, Mitchell J, Wulffhart Z, Dorian P: A
double-blind placebo-controlled evaluation of the human electrophysiologic effects of
zatebradine, a sinus node inhibitor. J Cardiovasc Pharmacol 1998;32(4):516-520.
Chiumello D, Pristine G, Slutsky AS: Mechanical ventilation affects local and systemic
cytokines in an animal model of ARDS. Am J Resp Crit Care Med 1999;160(1):109-116.
Chlorakos A, Langille BL, Adamson SL: Cardiovascular responses attenuate with repeated
nitric oxide synthesis inhibition in conscious fetal sheep. Am J Physiol 1998;274:H1472-H1480.
Chockalingham A, Bpharm MB, Campbell N, Cutler H, Drover A, Feldman R, Fodor G, Irvine
J, et al: Adherence to management of high blood pressure: Recommendations of the Canadian
Coalition for Blood Pressure Control. Can J Public Health, Special Insert 1998;89:I5-I7.
Christakis GT, Buth KJ, Goldman BS, Fremes SE, Rao V, Cohen G, Borger MA, Weisel RD:
Inaccurate and misleading valve sizing: A proposed standard for valve size nomenclature. Ann
Thorac Surg 1998;66:1198-1203.
Chukkapalli G, Karpik SR, Ethier CR: A scheme for generating unstructured grids on spheres
with application to parallel computation. J Computational Physics 1999;149:114-127.
Claudio JO, Liew CC, et al: Cloning and expression analysis of a novel WD repeat gene,
WDR3, mapping to 1p12-p13. Genomics 1999;59:85-89.
Claudio JO, Liew CC, et al: Identification of sequence-tagged transcripts differentially
expressed within the human hematopoietic hierarchy. Genomics 1998;50:44-52.
Cohen G, Feder-Elituv R, Iazetta J, Bunting P...Fremes SE: Phase 2 studies of adenosine
cardioplegia. Circulation 1998;98:225-233.
Cohen G, Shirai T, Weisel RD, Rao V, Merante F, Tumiati LC, Mohabeer MK, Borger MA, Li
R-K, Mickle DAG: Optimal myocardial preconditioning in a human model of ischemia and
reperfusion. Circ 1998;98(SuppII):184-196.
Cohen G, Shirai T, Weisel RD, Rao V, Merante F, Tumiati LC, Mohabeer MK, Borger MA, Li
RD, Mickle DAG: Optimal myocardial preconditioning in humans. Ann NY Acad Sci
1999;874:306-320.
Cole D, Peltekova VD, Rubin L, Hawker GA, Vieth R, Liew CC, Hwang DM, Evrovski J,
Hendy GN: A986S polymorphism of the calcium-sensing receptor and circulating calcium
concentrations. Lancet 1999;353:112-115.
Courtman DW, Cho A, Langille BL, Wilson GJ: Eliminating arterial pulsatile strain by
external banding induces medial but not neointimal atrophy and apoptosis in the rabbit. Am J
Path 1998;153(6):1723-1729.
Courtman DW, Schwartz SM, Hart CE: Sequential injury of the rabbit abdominal aorta induces
intramural coagulation and luminal narrowing independent of intimal mass: Extrinsic pathway
inhibition eliminates luminal narrowing. Circ Res 1998;82:996-1006.
Cowan KN, Jones PL, Rabinovitch M: Regression of hypertrophied rat pulmonary arteries in
organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C and
smooth muscle cell apoptosis. Circ Res 1999;84:1223-1233.
Cregg N, Cheng DCH, et al: Morbidity outcome in patients with hypertrophic obstructive
cardiomyopathy undergoing cardiac septal myectomy: Early extubation anesthesia versus high
dose narcotic anesthesia. J Cardiothorac Vasc Anesth 1999;13:47-52.
Cronenwett JL, Johnston KW: The united kingdom small aneurysm trial: Implications for
surgical treatment of abdominal aortic aneurysms. J Vasc Surg 1998;29:191-194.
Dai KS, Cuckerman E, Liew CC: Characterization of a novel gene encoding zinc finger
domains identified from expressed sequence tags (ESTs) of a human heart cDNA database. J
Mol Cell Cardiol 1998;30:2365-2375.
DeCampos KN, Keshavjee S, Liu M, Slutsky AS: Prevention of rapid reperfusion-induced lung
injury with PGE1 during the initial period of reperfusion. J Heart Lung Transplantation
1998;17(11):1121-1128.
Deliva RM, Ackermann U: Atrial natriuretic peptide and mechanisms of cardiovascular
control: Role of serotonergic receptors. Am J Physiol 1998;274:R711-R717.
Devlin GP…Butany J, Richards JA, Sole MJ, Schwartz L: Effect of a single bolus
intracoronary basic fibroblast growth factor on perfusion in an ischaemic procine model. Can J
Cardiol 1999;15(6):676-682.
Diaz RJ, Losito VA, Ford MA, Backx PH, Wilson GJ: The role of C1 channels in ischemic
preconditioning in rabbit heart. Circ Res 1999;84(7):763-775.
Diaz RJ, Losito VA, Ford MK, Mao GD, Backx PH, Wilson GJ: Chloride channel inhibition
blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular
myocardium. Circ Res 1999;84:763-775.
Dorian P, Newman D, Greene M: Implantable defibrillators and/or amiodarone: alternatives or
complementary therapies. Int J Clin Pract 1998;52(6):425-428.
Dorian P: Interactions between implantable devices and pharmacological agents. Cardiac
Electrophysiology Review 1998;2(2):151-153.
Dowd N, Cheng DCH, Karski J, Wong D, Carroll J, Sandler A: Intraoperative awareness in fast
track cardiac anesthesia. Anesthesiology 1998;89:1068-1073. (This article was featured in “This
Month in Anesthesiology”.) (Selected by the DanneMiller Memorial Educational Foundation to
be published in abstract form in Anesthesia File.) (Selected to be published as an abstract in 1999
year book of Anesthesiology and Pain Management.)
Dupuis J, Cernacek P, Tardif J, Stewart DJ, et al: Reduced pulmonary clearance of endothelin-1
in pulmonary hypertension. Am Heart J 1998;135(4):614-620.
Ethier CR, Coloma FM, Sit AJ, Johnson M: Two pore population in the inner wall endothelium
of Schlemm’s canal. Invest Ophthalmology and Visual Sci 1998;39:2041-2048.
Ethier CR, Coloma FM: Effects of ethacrynic acid on Schlemm’s canal inner wall and outflow
facility in human eyes. Invest Ophthalmology and Visual Science 1999;40:1599-1607.
Ethier CR, Croft MA, Coloma FM, Gangnon R, Ladd B, Kaufman PL: Study of ECA effects on
inner wall pores in living monkeys. Invest Ophthalmology and Visual Science 1999;40:13811391.
Ethier CR, Steinman D, Zhang X, Karpik SR, Ojha M: Flow waveform effects on end-to-side
anastomotic flow patterns. J Biomechanics 1998;31:609-617.
Fisher JA, Sommer LZ, Rucker J, et al: Isocapnic hyperpnea accerates carbon monoxide
elimination. Am J Resp Crit Care Med 1999;159(4):1289-1292.
Flalkov JA, Antonyshyn OM, Forrest CR, Farb R: Morphological and volumetric analysis of
post-traumatic enophthalmos using combined imaging modalities. IN: Craniofacial Surgery:
Proceedings of the VII International Congress of the International Society of Craniofacial
Surgery (L. Whitaker, ed). Monduzzi Editore, bologna, Italy, 1998;221-223.
Floras JS: Ambulatory blood pressure monitoring and the taxonomy of hypertension. J
Hypertension 1998;16:1719-1720.
Floras JS: Baroreflex sensitivity and heart-rate variability were associated with total cardiac
mortality following MI (Commentary). Evidence-Based Cardiovasc Med 1998;2:98-99.
Fodor G, Cutler H, Irvine J, Ramsden V, Tremblay G, Chockalingham A: Adherence to
nonpharmacologic therapy for hypertension: Problems and solutions. Can J Public Health,
Special Issue 1998;89:I12-I15.
Forrest CR, Pang CY: Discussion: Ischemic preconditioning improves the survival of skin and
myocutaneous flaps in a rat model by Kahir KS, Syed SA, Zink JR, Restifo RJ, Thomson JG.
Plast Reconstr Surg 1998;109:151-152.
Fried AG, Parker AB, Newton GE, Parker JD: Electrical and hemodynamic correlates of the
maximal rate of pressure rise in the human left ventricle. J Card Failure 1999;5:8-16.
Gloviczki P, North American Study Group: Mid-term results of endoscopic perforator vein
interruption for chronic venous insufficiency: Lessons learned from the North American
subfascial endoscopic perforator surgery registry. J Vasc Surg 1999;29:489-502.
Goodman LS, LeSage S: A tilt table simulation of the push-pull effect. DCIEM Technical
Report #1999-023, Defence Research and Development Board, Department of National Defence,
1999.
Gorbet MB, Yeo EL, Sefton MV: A flow cytometric study of in-vitro neutrophil activation by
biomaterials. J Biomed Mater Res 1999;44:289-297.
Gur E…Forrest CR: The vascularized pig fibula bone flap model: Effects of multiple segmental
osteotomies on growth and viability. Plast Reconstr Surg 1999;103:1436-1450.
Hall MJ, Ando S, Floras JS, Bradley TD: Magnitude and time course of hemodynamic
responses to Mueller maneuvers in patients with congestive heart failure. J Appl Physiol
1998;85:1476-1484.
Herridge MS, Slutsky AS, Colditz GA: Has high-frequency ventilation (HFV) been
inappropriately discarded in adult ARDS? Crit Care Med 1998;26(12):2073-2077.
Huang WY, Liew CC: Chromatin remodelling of the cardiac beta-myosin heavy chain gene.
Biochem J 1998;330:871-876.
Huang WY, Liew CC: Chromatin structure and cardiac gene expression. J Mol Cell Cardiol
1998;30:1673-1681.
Huntington K, Picard P, Moe G, Stewart DJ, Albernaz A, Monge JC: Increased cardiac and
pulmonary endothelin-1 mRNA expression in canine pacing-induced heart failure. J Cardiovasc
Pharm 1998;31(1):S424-S426.
Jhirad R, Kalman PG: Mycotic axillary artery aneurysm. J Vasc Surg 1998;28:708-709.
Johnston KW: Life expectancy after surgical repair of nonruptured abdominal aortic aneurysm.
IN: The Durability of Vascular and Endovascular Surgery. Ed. Greenhalgh RM. W.B. Saunders,
London England, 1999, pp135-147.
Jones PL, Jones FS, Zhou B, Rabinovitch M: Denatured type 1 collagen induction of vascular
smooth muscle cell tenascin-C gene expression is dependent upon a 3 integrin-mediated
mitogen-activated protein kinase pathway and a 122 bp promoter element. J Cell Sci
1999;112:435-445.
Kadokura M, Young DSF, Coles JG, et al: A novel assay for detecting human serum-induced
porcine endothelial cell apoptosis. Transplantation Proceeding 1998;30:2938-2940.
Kalman PG, Rappaport DC, Merchant N, Clarke K, Johnston KW: The value of late computed
tomographic scanning in identification of vascular abnormalities after abdominal aortic aneurysm
repair. J Vasc Surg 1999;29:442-450.
Kaprielian R, Wickenden AD, Kassiri Z, Parker TG, Liu P, Backx PH: Action potential and
[Ca2+]1 changes are related to reduction in Kv4.2 and Kv4.3 currents following myocardial
infarction in rat. J Physiol 1999;517:229-245.
Karski JM…Cheng DCH: The effect of three different doses of tranexamic acid on blood loss
after cardiac surgery with mild systemic hypothermia (32C). J Cardiothorac Vasc Anesth
1998;12:642-646.
Kashour T, Schwartz L: Coronary vasospasm as a cause of angina following interventional
recanalization. Can J Cardiol 1999;15:605-608.
Kasrai L, Forrest CR, Hearn TC, Szalai JP: A biomechanical analysis of the orbital-zygomatic
complex. IN: Craniofacial Surgery: Proceedings of the VII International Congress of the
International Society of Craniofacial Surgery (L. Whitaker, ed). Monduzzi Editore, Bologna,
Italy, 1998;25-26.
Kasrai L, Hearn T, Gur E, Forrest CR: A biomechanical analysis of the orbital-zygomatic
complex in human cadavers: Examination of load-sharing and failure patterns following fixation
with titanium and bioresorbable plating systems. J Craniofacial Surg 1999;10:237-243.
Keith M, Geranmayegan A, Sole MJ... Jeejeebhoy KN: Increased oxidative stress in patients
with congestive heart failure. J Am Coll Cardiol 1998;31:1352-1356.
Kerr CR, Boone J, Connolly SJ, Dorian P, et al: The Canadian Registry of Atrial Fibrillation: A
non-interventional follow-up of patients following the first diagnosis of atrial fibrillation. Am J
Cardiol 1998;82:82N-85N.
Khaykin Y, Dorian P, Tang D, Green M, Mitchell J, Wulffhart Z, Newman D: The effect of
sinus node depression on heart rate variability in humans using zatebradine, a selective
bradycardic agent. Can J Physiol Pharmacol 1998;76:806-810.
Kirkpatrick AW, Goodman LS, Gray GW, Smith T: Potential aerospace life support systems
applications in clinical medicine. DCIEM Technical Report #1999-026, Defence Research and
Development Board, Department of National Defence, 1999.
Kok LDS, Tsui SKW, Waye M, Liew CC, Lee CY, Fung KP: Cloning and characterization of a
cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart.
Biochem Biophys Commun 1999;225:717-721.
Lahootti S, Sefton MV: Methods for Microencapsulation with HEMA-MMA. IN: Methods in
Molecular Medicine, Vol XX: Tissue Engineering Methods and Protocols. JR Morgan, ML
Yamush (Eds). Humana Press Inc, Totowa, New Jersey, 1999;331-348.
Lamarche B, Carpentier A, Uffelman KD, Steiner G, Barrett PHR, Lewis GF: Triglyceride
enrichment of HDL enhances the in vivo metabolic clearance of HDL-associated apolipoprotein
A-1 in healthy human. J Clin Invest 1999;103:1191-1199.
Lamarche B, Lewis GF: Atherosclerosis prevention for the next decade. Risk assessment
beyond LDL cholesterol. Can J Cardiol 1998;14:841-851.
Law A, Wu J, Zeng LH, Wu TW: Aortic endothelia cells damaged by a nitric oxide donor and
protected by flavonoids. Life Sciences 1999;64(19):PL199-204.
Lee JK, Zaidi SHE, Liu P, Dawood F, Cheah AYL, Wen WH, Saiki Y, Rabinovitch M: A
serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function
following experimental murine myocarditis. Nature Med 1998;4:1383-1391.
Lee S, Tsui S, Chan K, Garcia-Barcelo M, Wayw M, Fung K, Liew CC, Lee C: Chromosomal
mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1
(FHL1). Gene 1998;216:163-170.
Lemieux S, Fontani R, Uffelman KD, Lewis GF, Steiner G: Apolipoprotein B48 and retinyl
palmitate are not equivalent markers of postprandial intestinal lipoproteins. J Lipid Res
1998;39:1964-1971.
Leveillee RJ, Pinchuk L, Wilson GJ, Block NL: A new self-expanding lined stent-graft in the
dog ureter: Radiological, gross, histopathological and scanning electron microscopic findings. J
Urology 1998;160(5):1877-1882.
Lewis GF, Carpentier A, Bilinski D, Giacca A, Vranic M: Counterregulatory response to
insulin-induced hypoglycemia differs according to the insulin delivery route. J Clin Endocrinol
Metab 1999;84:1037-1046.
Lewis GF, Carpentier A, Vranic M, Giacca A: Resistance to insulin’s acute direct hepatic effect
in suppressing steady state glucose production in individuals with Type 2 diabetes mellitus.
Diabetes 1999;48:570-576.
Lewis GF, Giacca A, Vranic M, Steiner G: Acute direct and indirect effects of insulin on
hepatic glucose and VLDL production. Curr Opinion in Endocrin Diabetes 1998;5:235-245.
Lewis GF, Vranic M, Giacca A: Role of free fatty acids and glucagon in the peripheral effect of
insulin on glucose production in humans. Am J Physiol 1998;275:E177-E186.
Li GM, Li R-K, Mickle DAG, Weisel RD, et al: Elevated insulin like growth factor-1 and
transforming growth factor B-1 and their receptors in patients with idiopathic hypertrophic
obstructive cardiomyopathy: A possible mechanism. Circ 1998;98(SuppII):144-150.
Li K, Stewart DJ, Ward HF: Technology evaluation: Gene therapy (FGF-5), Vical. Current
Opinion in Molecular Therapeutics 1999;1(2):260-265.
Li RA, Tsushima RG, Backx PH: Targeting local anesthetics to cardiac Na+ channels. Circ Res
1999;85(1):88-98.
Li R-K, Jia Z-Q, Weisel RD, Merante F, Mickle DAG: Smooth muscle cell transplantation into
myocardial scar tissue improves heart function. J Molecular Cell Cardiol 1999;31:513-522.
Liu M…Li R-K, Yan J: Bio-stretch, a computerized cell strain apparatus for three dimensional
organotypic cultures. In Vitro Cell Dev Biology 1999;35:87-93.
Lorenze-Filho G, Rankin F, Bies I, Bradley TD: Effects of inhaled CO2 and O2 on CheyneStokes respiration in patients with heart failure. Am J Respir Crit Care Med 1999;159:14901498.
Lorenzi-Filho G, Dajani HR, Leung RST, Floras JS, Bradley TD: Entrainment of blood
pressure and heart rate oscillations by periodic breathing. Am J Resp Crit Care Med
1999;159:1147-1154.
Losita VA, Tsushima G, Diaz RJ, Wilson GJ, Backx PH: Preferential regulation of rabbit
cardiac L-type Ca2+ current by glycolytic derived ATP via a direct allosteric pathway. J Physiol
1998;511(Pt.1):67-78.
Mason CAE...Rabinovitch M: Gene transfer in utero biologically engineers a patent ductus
arteriosus in lambs by arresting fibronectin-dependent neointimal formation. Nature Med
1999;5:176-188.
Mason TM... Lewis GF, Giacca A: A prolonged elevation of plama free fatty acids desensitises
the insulin secretary response to glucose in vivo in rats. Diabetes 1999;48:524-530.
Mehta S, Slutsky AS: Mechanical ventilation in acute respiratory distress syndrome: evolving
concepts. Monaldi Arch Chest Dis 1998;53(6):647-653.
Melo LG, Veress AT, Ackermann U, Pang SC, Flynn TG, Sonnenberg H: Chronic hypertension
in ANP knockout mice: Contribution of peripheral resistance. Reg Peptides 1999;79:109-115.
Melo LG, Veress AT, Ackermann U, Sonnenberg H: Chronic regulation of arterial blood
pressure by ANP: Role of endogenous vasoactive endothelial factors. Am J Physiol
1998;275:H1826-H1833.
Melo LG, Veress AT, Chong CK, Ackermann U, Sonnenberg H: Salt-sensitive hypertension in
ANP knockout mice is prevented by AT-1 receptor antagonist Losartan. Am J Physiol
1999;277:R624-R630.
Mentzer R…Weisel RD, Wellons HA, Barker ML, Lasley RD: Adenosine myocardial
protection: preliminary results of a phase II clinical trial. Ann Surg 1999;229:643-649.
Merante F, Mickle DAG, Weisel RD, Li R-K, Tumiati LC, Rao V, Williams WG, Robinson
BH: Myocardial aerobic metabolism is impaired in a cell culture model of cyanotic heart
disease. Am J Physiol 1998;275(Heart Circ Physiol):H1673-H1681.
Milone SD, Newton GE, Parker JD: Hemodynamic and biochemical effects of 100% oxygen
breathing in humans. Can J Physiol and Pharmacol 1999;77:124-130.
Milone SD, Pace-Asciak, Reynaud D, Azevedo ER, Newton GE, Parker JD: Biochemical,
hemodynamic and vascular evidence concerning the free radical hypothesis of nitrate tolerance. J
Cardiovasc Pharm 1999;33:685-690.
Moe G, Albernaz A, Naik GO, Kirchengast M, Stewart DJ: Beneficial effects of long-term
selective endothelin A receptor blockade in canine experimental heart failure. Cardiovasc Res
1998;39:571-579.
Moore JA, Steinman DA, Holdsworth DW, Ethier CR: Accuracy of computational
hemodynamics in complex arterial geometries reconstructed from MRI. Ann Biomed Engin
1999;27:32-41.
Moore JA, Steinman DA, Prakash S, Johnston KW, Ethier CR: A numerical study of blood
flow patterns in anatomically realistic and simplified end-to-side anastomoses. ASME J
Biomechanical Eng 1999;121:265-272.
Najm HK, Van Arsdell GS, Watzka S, Hornberger L, Coles JG, Williams WG: Primary repair is
superior to initial palliation in children with atrioventricular septal defect and tetralogy of fallot. J
Thorac Cardiovasc Surg 1998;116:905-913.
Najm HK, Williams WG, Chuaratanaphong S, Watzka S, Coles JG, Freedom RM: Primum
atrial septal defect in children: Early results, risk factors and freedom from reoperation. Ann
Thorac Surg 1998;66:829-835.
Naughton MT, Floras JS, Rahman MA, Jamal M, Bradley TD: Respiratory correlates of
muscle sympathetic nerve activity in heart failure. Clinical Science 1998;95:277-285.
Newton GE, Azevedo ER, Parker JD: Inotropic and sympathetic responses to the intracoronary
infusion of a _2-receptor magonist: A human in vivo study. Circulation 1999;99:2402-2407.
Nguyen QT, Cernacek P, Stewart DJ, Picard P, Rouleau JL: Endothelin-A receptor blockade
causes adverse left ventricular remodelling but improves pulmonary artery pressure
postinfarction in the rat. Circulation 1998;98:2323-2330.
Nishida O, Arellano R, Cheng DCH, DeMajo W, Kavanagh BP: Gas exchange and
hemodynamics in experimental pleural effusion. Crit Care Med, 27:583-587, 1999. (This article
was editorial by Dobyns EL: Pleural effusions and hypoxemia. Crit Care Med 1999;27:472.)
Notarius CF, Ando S, Rongen GA, Senn BL, Floras JS: Resting muscle sympathetic nerve
activity and peak oxygen uptake in heart failure and normal subjects. Eur Hear J 1999;20:880887.
Notarius CF, Butler GC, Ando S, Pollard MJ, Senn BL, Floras JS: Dissociation between
microneurographic and heart rate variability estimates of sympathetic tone in normal and heart
failure subjects. Clinical Science 1999;96:557-565.
Ogilvie RI, Zborowska-Sluis D: Captopril and angiotensin II (AT1) receptor antagonist therapy
in a pacing model of heart failure. Can J Cardiol 1998;14:1025-1033.
Ogilvie RI: Isolated systolic hypertension in the elderly – what’s next? Geriatric Nephrology
and Urology 1998;8:3-5.
Packer M, Cohn JN... Sole MJ: Consensus recommendations for the management of chronic
heart failure. Am J Cardiol 1999;83(2A):1-38A.
Pang CY, Zhang J, Xu H, Lipa J, Forrest CR, Neligan PC: Role and mechanism of endothelin
B (ET-B) receptors in mediating ET-1-induced vasoconstriction in pig skin. Am J Physiol
1998;275:R1066.
Park H, Moore J, Trass O, Ojha M: Photochromic grid analysis of vorticity and pressure fields
in a 2-D flow field. Experiments in Fluids 1999;26:55-62.
Parker JD, Parker JO: Organic nitrate therapy for stable angina pectoris. N Engl J Med
1998;338:520-531.
Parker JD, Thiessen JJ, et al: Human endothelin-1 clearance kinetics revealed by a radiotracer
technique. J Parmacol and Exp Ther 1999;289:261-265.
Picard P... Stewart DJ: Coordinated up-regulation of the cardiac endothelin system in a rat
model of heart failure. J Cardiovasc Pharm 1998;31(1):S294-S297.
Pierre AF…Slutsky AS, Keshavjee SH: Rapid reperfusion causes stress failure in ischemic rat
lungs. J Thorac Cardiovasc Surg 1998;116(6):932-942.
Pierre AF, Xavier AM, Liu M, Cassivi SD, Lindsay TF, Marsh HC, Slutsky AS, Keshavjee SH:
Effect of complement inhibition with soluble complement receptor 1 on pig allotransplant lung
function. Transplantation 1998;66(6):723-732.
Pitt B, Waters D, Brown WV, van Bowen AJ, Schwartz L, et al: Aggressive lipid-lowering
therapy compared with angioplasty in stable coronary artery disease. N Engl J Med 1999;341:7076.
Prasad N, Ali H, Schwartz L: Short and long term outcome of balloon angioplasty for
compromised side branches after intracoronary stent deployment. Cathet Cardiovasc Intervent
1999;46:21-24.
Prie S, Stewart DJ, Dupuis J: ETA receptor blockade improves nitric oxide-mediated
vasolilation in monocrotaline-induced pulmonary hypertension. Circulation, 1998;97(21):21692174.
Puybasset L, Cluzel P, Chao N, Slutsky AS, Coriat P, Rouby JJ: A CT scan assessment of
regional lung volume in acute lung injury. Am J Resp Crit Care Med 1998;158(5pt1):1644-1655.
Qi X, Newman D, Dorian P: Azimilide decreases defibrillation voltage requirements and
increases spatial organization during ventricular fibrillation. J Interventional Cardiac
Electrophysiology 1999;3:61-67.
Ranieri VM, Slutsky AS: ARDS: Physiological evaluation of the clinical trials. Monaldi Arch
Chest Dis 1998;53(6):644-646.
Rao V, Komeda M, Weisel RD, Cohen G, Borger M, David TE: Should the pericardium be
closed routinely after heart surgery? Ann Thorac Surg 1999;67:484-488.
Rao V, Merante F, Weisel RD…Li R-K, Mickle DAG, Robinson BH: Insulin stimulates
pyruvate dehydrogenase and protects human ventricular cardiomyocytes from simulated
ischemia. J Thor Cardiovasc Surg 1998;116(3):485-494.
Rongen GA, Brooks SC, Pollard MJ, Ando S, Dajani HR, Notarius CF, Floras JS: Effect of
adenosine on heart rate variability in humans. Clinical Science 1999;96:597-604.
Sah R, Tsushima R, Backx PH: Reconstitution of inactivation by local anaesthetics in Na+
channels containing the equine hyperkalemic periodic paralysis mutation. Am J Physiol (Cell)
1998;275:C389-C400.
Sandor P, Baker B, Irvine J, Dorian P, McKessock D, Mendlowitz S: Effect of fluoxetin and
doxepin in the treatment of meloncholia in depressed out patients. Depression and Anxiety
1998;7:69-72.
Schwartz L, Brister S, Bourassa M, Peniston C, Buchanan M: Interobserver reproducibility and
biological variability of the Surgicatt II bleeding time. J Thrombosis and Thrombolysis
1998;6:155-158.
Shapiro PA, Lespérance F, Frasure-Smith N, O’Connor CM, Baker B, Jiang JW, Dorian P,
Harrison W, Glassman AH: An open-label preliminary trial of sertraline for treatment of major
depression after acute myocardial infarction (The “SADHAT” Study). Am Heart J
1999;137:1100-1106.
Shoichet MS, Sefton MV: Immunoisolation. IN: Handbook of Biomaterials Evaluation, 2nd
Edition. A. van Recum (Ed), Taylor & Francis, Chapter 26, 1999;411-424.
Silkoff PE, McClean PA, Caramori M, Slutsky AS, Zamel N: A significant proportion of
exhaled nitric oxide in large airways in normal subjects. Respir Physiol 1998;113(1):33-38.
Silkoff PE, McClean PA, Slutsky AS, et al: Exhaled nitric oxide and bronchial hyperreactivity
after inhaled beclomethasone in mild asthma. Am J Resp Crit Care Med 1999;159(3):940-944.
Sloan EP, Natarajan M, Baker B, Dorian P, et al: Nocturnal and daytime panic attacks:
Comparison of sleep architecture, heart rate variability and response to sodium lactate infusion.
Biol Psychiatry 1999;45(10):1313-1320.
Slutsky AS: Genetics of asthma: From chicken soup to Napoleon to Toronto. J Clin Pharmacol
1999;39:36-41.
Smith PJW, Teichert-Kuliszewska K, Monge JC, Stewart DJ: Regulation of endothelin-B
receptor mRNA expression in human endothelial cells by cytokines and growth factors. J
Cardiovasc Pharm 1998;31(1):S158-S160.
Sommer L... Fisher JA: A simple breathing circuit minimizing changes in alveolar ventilation
during hyperpnoea. Eur Resp J 1998;12:698-701.
Stewart DJ: Impact of endothelin-1 on vascular structure and function. Am J Cardiol
1998;82(10A):14S-16S.
Stewart DJ: Update on endothelin. Can J Cardiol 1998;14(D):11-13.
Sun K, Adamson SL, Yang K, Challis JRG: Interconversion of cortisol and cortisone by 11betahydroxysteroid dehydrogenases type 1 and 2 in the perfused human placenta. Placenta
1999;20:13-19.
Taylor BV, Oudit GY, Kalman PG, Liu P: Clinical and pathophysiological effects of active and
passive smoking on the cardiovascular system. Can J Cardiol 1998;14:1129-1139.
The Diabetes Atherosclerosis Intervention Study (DAIS): Quantitative coronary angiographic
analysis of coronary artery artherosclerosis. Catheterization and Cardiovascular Diagnosis
1998;44:249-256.
Tkác I, Silver F, Lamarche B, Lewis GF, Steiner G: Serum creatinine level is an independent
risk factor for the angiographic severity of internal carotid artery stenosis in subjects with
previous transient ischemic attacks. J Cardiovasc Risk 1998;5:79-83.
Tkacova R, Rankin F, Fitzgerald FS, Floras JS, Bradley TD: Effects of continuous positive
airway pressure on obstructive sleep apnea and left ventricular afterload during sleep in heart
failure patients with obstructive sleep apnea. Circulation 1998;98:2269-2275.
Tremblay LN, Slutsky AS: Ventilator-induced injury: From barotrauma to biotrauma. Proc
Assoc Am Physicians 1998;110(6):482-488.
Tsushima RG, Borges A, Backx PH: Inactivated state dependence of -scorpion toxin
modulation of sodium channels. Pflugers Arch 1999;437:661-668.
Tsushima RG, Wickenden AD, Bouchard R, Liu P, Backx PH: Role of the L-type channel in rat
myocardial Fe2+ uptake and overload. Circ Res 1999;84(11):1302-1309.
Villar J, Petty TL, Slutsky AS: ARDS in its middle age: What have we learned? Applied
Cardiopulmonary Pathophysiology 1998;7:167-172.
Weisenthal SR…Lewis GF, Mari A, Giacca A: Free fatty acids impair hepatic insulin extraction
in vivo. Diabetes 1999;48:766-774.
Wickenden AD, Kaprielian R, Tegla TJ, Backx PH: Regional contributions of Kv1.4, Kv4.2
and Kv4.3 to the transient outward current in rat ventricle. Am J Physiol 1999;276(5Pt2):H1599H1607.
Wickenden AD, Tsushima RG, Losito V, Kaprielian R, Backx PH: Effects of Cd2+ and Kv4.2
and Kv1.4 in Xenopus oocytes and the transient outwart current in rat and rabbit ventricular
myocytes. Cell Physiol Biochem 1999;9(1):11-28.
Wickenden AD... Parker TG, Liu P, Backx PH: The relationship of K+ current expression and
[Ca2+]1 to heart disease progression. Cardiovasc Res 1998;37:312-323.
Wu J, Sugiyama H, Zeng LH, Mickle DAG, Wu TW: Evidence of Trolox and some gallates as
synergistic protectors of erythrocytes against peroxyl radicals. Biochem Cell Biol 1998;76:661664.
Yamamoto Y, Sefton MV: Surface grafting of poly(ethylene glycol) onto poly(acrylamide-covinyl amine) cross-linked films under mild conditions. J Biomater Sci Polymer Edn 1998;9:427437.
Yan DB, Flanagan JG, Farra T, Trope GE, Ethier CR: Study of regional deformation of the
optic nerve head using scanning laser tomography. Current Eye Research 1998;17:903-916.
Zaidi SHE, Hui C-C, Cheah AYL, You X-M, Husain M, Rabinovitch M: Targetedoverexpression of elafin protects mice against cardiac dysfunction and mortality following viral
myocarditis. J Clin Invest 1999;103:1211-1219.
Zhou B, Coulber C, Rabinovitch M: Tissue-specific and developmental regulation of
transforming growth factor- expression in fetal lamb ductus arteriosus endothelial cells. Pediatr
Res 1998;44:865-872.
Zhou B, Rabinovitch M: Microtubule involvement in translational regulation of fibronectin
expression by light chain 3 of microtubule-associated protein 1 in vascular smooth muscle cells.
Circ Res 1998;83:481-489.
ACKNOWLEDGEMENTS:
The Cardiovascular Sciences Collaborative Program would like to thank the following industry
sponsors for their generous support.
Bristol-Myers Squibb
Medtronic Canada
Merck Frosst Canada Inc.
Pfizer Canada