Chapter 5: Circulatory System Conditions Introduction General Function: the Circulatory System Delivers nutrients, fuel, Delivers oxygen Removes wastes Maintains temperature Clotting Protection from pathogens Chemical balance Massage can support or impair this function Structure and Function: the Heart Septum divide L/R Right side pumps to pulmonary circuit Left side pumps to systemic circuit AV valves divide into top and bottom halves Atria, ventricles “lub-dup” is closing of AV and semilunar valves Ventricles work harder than atria Implications for seriousness of heart attacks (Fig. 5.1) Structure and Function: Blood Vessels Aorta → arteries → arterioles → capillaries → venules → veins → vena cava → heart Closed system: platelets and RBCs should not be able to leave 60,000 miles of vessels 3-ply construction of veins and arteries: Tunica intima (endothelium) Tunica media (smooth muscle) Tunica externa/ adventitia (connective tissue) Capillaries are simple squamous epithelium: excellent for permeability Structure and Function: the Blood Red blood cells (erythrocytes) Born in bone marrow Production stimulated by EPO from kidneys 98% of all blood cells Lifespan = 4 months Dead RBCs removed by spleen Turnover: 2 million/second No nuclei, lots of hemoglobin (iron-based) Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 1 5 million per mm3 Biconcave discs: all identical, smooth and flexible White blood cells (leukocytes) Translucent Different types for different functions Neutrophils, basophils, eosinophils, monocytes, lymphocytes (Fig. 5.2) Platelets (thrombocytes) Fragments of larger cells (megakaryocytes) Smooth until stimulated, then spiky, sticky Release chemicals that weave fibrin Make thrombi, crusts Blood Disorders Anemia Embolism, thrombus Hemophilia Leukemia Myeloma Sickle cell disease Thrombophlebitis, deep vein thrombosis Vascular Disorders Aneurysm Atherosclerosis Hypertension Raynaud syndrome Varicose veins Heart Conditions Heart attack Heart failure Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 2 Anemia Definition Insufficient 02 carrying capacity Often a symptom or complication rather than freestanding problem Etiology Either a shortage of RBCs or a shortage of hemoglobin Leads to low O2 carrying capacity Process depends on type of anemia Types of Anemia Idiopathic a.: May be due to poor nutritional uptake due to stress or other factors Nutritional a.: Something vital is missing from the diet: iron folic acid vitamin B12 Can lead to pernicious anemia, brain damage Copper, protein, some others… (Fig. 5.3) Hemorrhagic a.: From blood loss Trauma (acute) Slow leak (chronic) Ulcers, kidney disease, heavy menstruation Hemolytic a.: Premature destruction of RBCs Splenomegaly, jaundice may also be present Reticulocytes (immature RBCs) increase Aplastic a.: Bone marrow is not functioning All blood cells are affected Can be autoimmune, renal failure, folic acid deficiency, viral, exposure to radiation… Myelodysplastic anemia: bone marrow makes non-functioning cells: risk of leukemia, myeloma Secondary a.: Due to underlying cause: Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 3 Ulcers Kidney disease Hepatitis Acute infection Blood cancer Signs and Symptoms Fatigue Pallor Dyspnea, rapid breathing Rapid heartbeat Intolerance to cold Heart problems Treatment Depends on underlying cause Medication Transfusion, stem cell implants, other strategies Medications Oral, injected nutritional supplements Steroidal anti-inflammatories for autoimmune disease Synthetic EPO to boost RBC production Massage Risks: Anemia can be part of other diseases that contraindicate massage. Anything that compromises sensation (pernicious anemia) or that is related to infection or cancer requires special adaptation for bodywork. Benefits: Massage may help with fatigue, but probably makes no changes in blood cell production or nutrition. A client who manages anemia and can adapt to the changes that massage brings about is a good candidate for bodywork. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 4 Embolism, thrombus Definition Embolism: traveling clot Thrombus: lodged clot (Fig. 5.4) Etiology Platelets flow through circulatory system; activated by any rough spot or inflammatory chemicals Clots form at sites of damage, areas of slow, irregular blood flow Clots are constantly forming and melting Sometime pro-clotting mechanism is stronger than anti-clotting Clots may stay in place (thrombi) or fragment and travel (emboli) Emboli travel until vessel is too small to pass through Types of Embolism, Thrombus Venous thrombosis: see thrombophlebitis, deep vein thrombosis Pulmonary embolism: From a clot that forms on venous side of systemic circuit: fragments and travels to lungs Often related to deep vein thrombosis, complications of trauma, orthopedic surgery Risk factors: Other cardiovascular disease Pregnancy Overweight Smoking Hormone supplements (Fig. 5.5) Arterial thrombus: Complication of atherosclerosis Made worse with chronic inflammation, stress Clots can grow on site to occlude the artery or they can fragment and travel (= embolism) Arterial embolism: Complication of atherosclerosis, atrial fibrillation, rheumatic heart disease Often made of clotted blood, can be other debris Brain, coronary arteries, kidneys, legs are most common sites; damaged tissue is infarction Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 5 (Fig. 5.6) Signs and Symptoms May be silent Pulmonary embolism Dyspnea, hemoptysis, lightheadedness, chest pain, sweating Arterial embolism: Sharp, tingling pain, tissue damage and death Treatment Medications Surgery Supplement O2 if necessary Compression stockings Medications Antiplatelet drugs Anticoagulants Thrombolytics Massage Risks: A client with a tendency to form clots may not be able to adapt to mechanical types of bodywork; whether the risk is local or systemic depends on the type of bodywork. Benefits: Non-mechanical forms of bodywork may be soothing and supportive for clients at risk for embolism or thrombus. Clients with a history of problems but no lingering problems can enjoy massage with no cautions. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 6 Hemophilia Definition Genetic disorder: Usually x-linked Absence of various clotting factors Etiology 12 distinct clotting factors help form clots Person with hemophilia has difficulty forming solid, long-lasting clots because of clotting factor insufficiency Don’t bleed faster, do bleed longer than others Rated as mild, moderate, severe Severe hemophilia = 60% of diagnoses; <1% normal clotting factors Usually an x-linked genetic mutation Carried by mothers, passed on to sons Complications Leading COD in children with hemophilia is intracranial bleeding Bleeding into joint capsules with inflammation and extensive damage: Hemophiliac arthritis Muscle and nerve damage Compartment syndrome, contracture Infected blood products Types of Hemophilia Type A: Most common form, about 80% of all cases Deficiency of clotting factor VIII Type B: AKA Christmas disease Insufficient Factor IX About 15% of cases Von Willebrand disease: Dysfunction of von Willebrand factor Helps Factor VIII Genetic mutation, ranges in severity Not x-linked; men and women affected equally Signs and Symptoms Signs at birth: umbilical cord bleeds excessively Early childhood: infant/toddler accidents Bruising, hematomas, nosebleeds, hematuria, joint pain from bleeds into capsule Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 7 Can be from trauma or spontaneous Treatment Supplement clotting factors Can be done at home now, prophylactically or after injury Careful exercise, weight control Medications Concentrated clotting factors Recombinant clotting factors Desmopressing to promote clotting factor production Antifibrinolytics to slow clot breakdown Massage Risks: Severe hemophilia contraindicates rigorous bodywork or anything that might cause bruising. Consult with client and health care team for other cautions. Benefits: Gentle or energetic massage can help with pain and stress. For milder cases massage that fits within the limitations of the tissues to avoid bruising is appropriate Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 8 Leukemia Definition “White blood”: Cancer of bone marrow Overlap between leukemia and lymphoma 38,000 diagnoses in US/year 200,000 survivors alive today Etiology Myeloid or lymphoid cells make most WBCs in bone marrow Leukemia happens when mutation leads to production of non-functioning WBCs Can be acute (aggressive) or chronic (slow-growing) Usually acquired (not inherited) genetic mutations Exposure to toxins, radiation Untreated disease leads to death from excessive bleeding, infection Types of Leukemia Acute myelogenous leukemia (AML): Aggressive cancer of meyloid cells Mostly in people 65+ Linked to exposure to… Radiation Chemo for other cancers Benzene Can form tumors outside marrow Chronic myelogenous leukemia (CML): Slowly progressive Affects myeloid cells Traced to specific chromosome Not usually very aggressive Can change to behave like AML Acute lymphocytic leukema (ALL): Aggressive cancer of all lymphocytes Most common among children All other marrow activity is suppressed Mutated cells can gather in nodes, CNS Chronic lymphocytic leukemia (CLL): Slowly progressive Affects lymphocytes Mostly B-cells Can be stable and non-progressive for long periods Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 9 Signs and Symptoms Bone marrow dysfunction Suppressed production of normal blood cells Fatigue, anemia Easy bruising, bleeding Chronic infections Others: fever, headache, weight loss, abdominal pain, enlarged lymph nodes Treatment Depends on what cells have been affected Chemotherapy Radiation therapy if nonresponsive to chemo Bone marrow transplant Biologic (targeted) therapies Treatments can exacerbate symptoms Medications Chemotherapy Biologic (targeted) therapy, e.g., interferon, monoclonal antibodies Drugs to mitigate side effects of chemotherapy Massage Risks: Patients have a high risk of bruising, bleeding and infection. It is best to consult with the patient and health care team about timing massage with treatment options for the best outcomes. Benefits: Bodywork has many benefits to offer cancer patients, as long as appropriate precautions are taken. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 10 Myeloma Definition “Mye”= marrow; “oma”= tumor Cancer of bone marrow, specifically maturing B-cells Mostly in people 50 years + Twice as common among African Americans compared to general population Etiology Normally, only a few B-cells stay in bone marrow instead of migrating to lymph tissue B-cells may experience a DNA mutation Proliferate into tumors Secrete cytokines that block osteoblast activity, stimulate osteoclasts Bone thinning, holes, fractures Produce faulty antibodies Tumors can interfere with bone marrow function Faulty antibodies are shed in urine (causing kidney damage) Types of Myeloma Multiple myeloma: Tumors grow simultaneously at multiple sites Most common form, 90% of all diagnoses Solitary myeloma: A single tumor in bone marrow Extramedullary plastocytoma: Growth of tumors outside of bone tissue Skin, muscle, lung, elsewhere Signs and Symptoms Silent early; proteins may be tracked by urinalysis Bone pain, fractures Anemia, infections, bleeding Kidney problems Amyloidosis (inflammatory proteins congregate in heart, lungs, other organs) Treatment “Watchful waiting” Chemotherapy, bone marrow stem cell transplantation Medications Chemotherapy Drugs to slow angiogenesis Corticosteroids, esp. for amyloidosis Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 11 Bisphosphonates to promote bone density Synthetic EPO for RBC production Massage Risks: Myeloma patients have a high risk for fractures. Other complications may be related to the cancer or its treatment; consult with the patient and health care team for best results. Benefits: Gentle work can be helpful for pain, anxiety, sleep and other benefits. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 12 Sickle cell disease (SCD) Definition Autosomal recessive genetic condition Production of abnormal hemoglobin Most common in blacks, Hispanics, Mediterraneans, from Middle East 2 million in US have SC trait 30,000 in US have SCD Etiology Having 1 gene: sickle cell trait Having 2 genes: sickle cell disease Hemoglobin production is abnormal RBCs have sickle shape RBCs get caught at capillaries RBC lifespan is shortened (Fig. 5.7) Complications Sickle-cell crises: infarctions Hand-foot syndrome Organ damage Esp. spleen, liver, kidneys, brain Infections (lost spleen function) Gallstones Vision loss Acute chest syndrome (looks like pneumonia) Others: Delayed growth, chronic skin ulcers at lower legs, priapsim (Fig. 5.8) Signs and Symptoms Inadequate O2 carrying capacity Fatigue Shortness of breath Pallor Jaundice, splenomegaly Other complications Treatment Work to limit severity, frequency of SC crises OTC pain meds, hot pack Heavier painkillers Prophylaxis for pneumonia Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 13 Medications Analgesics Prophylactic antibiotics Chemotherapeutic agents for adults Supplement folate Massage Risks: Clients with SCD have compromised circulatory function; any bodywork must be adapted to respect this serious limitation. Benefits: Massage for pain and anxiety relief, without intrusive mechanical intent can be an important part of an SCD patient’s quality of life. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 14 Thrombophlebitis, Deep Vein Thrombosis Definition Veins have become obstructed with clots Usually calves, thighs, pelvis Thrombophlebitis = lesser, greater saphenous veins DVT= popliteal, femoral, iliac veins Etiology Thrombi= stationary clots; they can fragment and travel Usually to lung → pulmonary embolism Virchow triad: Injury to endothelium Hypercoagulability Venous stasis Possible triggers: Physical trauma Varicose veins Local infection Physical restriction Immobility Pregnancy and childbirth Certain types of cancer Surgery Hormone supplements Other factors: cigarette smoking, hypertension, paralysis, and some genetic conditions Signs and Symptoms May be obvious with signs of inflammation Itchy, hard cord Sometimes distal edema Chronic problem → skin rashes, ulcers With infection: fever, malaise DVT is more dangerous, higher risk of serious damage May show pitting edema (Fig. 5.9) Treatment Thrombolytics to break clots; anticoagulants to prevent future ones Risk of bruising, bleeding Pneumatic compression, support hose for DVT Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 15 Superficial thrombophlebitis: hot packs, analgesics, gentle exercise Vena cava filter Medications Aspirin Anticoagulants Heparin, warfarin Thrombolytics Massage Risks: A client with a diagnosed blood clot is not a good candidate for rigorous massage until the situation is stable. Clients who use anticoagulants are at risk for bleeding and bruising. Benefits: A client who has successfully treated a clot is a good candidate for massage. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 16 Aneurysm Definition Bulge in blood vessel wall or heart Usually at aorta or in brain Etiology If walls of high-pressure arteries lose elasticity, they can bulge As aneurysm grows, walls get thinner Usually happens at thoracic or abdominal aorta, or base of brain Identified when diameter is 150% of normal Can happen at multiple sites Sometimes the whole ventricle of heart can bulge Factors: Compromised smooth muscle Smoking Congenitally weak arterial wall muscle Inflammation Untreated syphilis Trauma Rupture is almost always fatal Types of Aneurysm Saccular a.: Usually at thoracic or abdominal aorta Wall bulges like a rounded sack Throbbing and pressure on other structures Fusiform a.: Common version Bulge is tubular for a few inches Berry a.: Small bulges in the brain Dissecting a.: AKA “false aneurysm” Least common, most painful The aorta wall splits between the tunica intima and tunica media Aorta may dissect without an aneurysm (Figs. 5.10 and 5.11) Signs and Symptoms Sometimes silent May press on other structures: Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 17 Dysphagia, chest pain, hoarseness, coughing (thoracic aorta) Throbbing lump near umbilicus back pain (abdominal aorta) Headache, numbness, weakness (brain) Treatment Endovascular or open surgery Replacement graft, Dacron substitute, stent Small bulges may not need immediate repair Medications Antihypertensives Analgesics Massage Risks: Research suggests that massage can have a variable affect on blood pressure. A client with an aneurysm may have a limited capacity to adapt to these challenges. Benefits: A client with a stable aneurysm can receive massage that doesn’t challenge his/her capacity for cardiovascular adaptation. Options: Bodywork focused on dropping blood pressure without adding cardiovascular challenge is probably safe for aneurysm patients. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 18 Atherosclerosis Definition Subtype of arteriosclerosis Hardening of large, medium-sized arteries due to plaque Damage causes spasm, blood clots Diameter is occluded (Fig. 5.12) Etiology Multifactoral process Basic progression: 1. Endothelial damage: Occurs most readily at branches or sharp curves 2. Monocytes move in, become macrophages 3. Macrophages take up LDL: Become “foam cells”: beginning of plaque 4. Foam cells infiltrate and damage smooth muscle tissue. 5. Platelets arrive: Secrete growth factors Form clots Cause vascular spasm See animation at thePoint.lww./Werner5e Complications Hypertension (circular relationship) Aneurysm Arrhythmia Thrombus, embolism Angina pectoris Stable Unstable Heart attack Risk Factors Non-modifiable risk factors: Heredity, genetics Gender Age Kidney disorders Modifiable risk factors: Smoking: High cholesterol levels High blood pressure Sedentary lifestyle Diabetes Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 19 Other risk factors: C-reactive protein Homocysteine Others: BMI, fibrinogen, lipoproteins, Types of Atherosclerosis Carotid artery disease: Plaques form in carotid arteries Set-up for TIA, ischemic stroke (Fig. 5.13) Coronary artery disease: Atherosclerosis at coronary arteries surrounding the heart Occlusion can lead to heart damage– heart attack See animation at thePoint.lww.com/Werner5e (Fig. 5.14) Peripheral artery disease: Atherosclerosis away from the neck, heart Abdomen, legs are frequent sites Intermittent claudication Erectile dysfunction Stasis dermatitis Gangrene Skin ulcers (Fig. 5.15) Signs and Symptoms None early: 50% occlusion before dysfunction (angiogenesis, adaptability) Later: poor stamina, shortness of breath, complications Treatment Diet and exercise Drugs Surgery: Bypass, angioplasty, endarterectomy Medications Cholesterol management drugs Antihypertensives Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 20 Anticoagulants, anti-platelet drugs Anti-angina drugs Massage Risks: It is safe to assume that most adults have some level of atherosclerosis in the US. If this has led to other forms of heart disease or has compromised function, then bodywork must be appropriately adjusted. Benefits: A person with atherosclerosis who is active and engaged in his or her health can enjoy many benefits from massage that is geared to fit within adaptive capacity. Options: Because no major blood vessels are accessible on the back, it is possible to give a satisfying massage without putting potentially compromised arteries at risk. Be careful at the anterior trapezius, because of the carotid arteries. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 21 Hypertension Definition High blood pressure Persistently above 140/90 About 1/3 of all US adults Men > women till age 65 Men = women after age 65 African-Americans more vulnerable than other races Etiology Internal and external pressure on arteries See animation at thePoint.lww.com/Werner5e Damage begins to accrue at 155+ over 75+ Damage is progressive and silent, leading to many complications Complications Edema Atherosclerosis Stroke Enlarged heart, heart failure Aneurysm Kidney disease Retinopathy Types of Hypertension Essential h.: Not dependent on underlying factor About 95% of all diagnoses Secondary h.: A temporary complication of another disorder Pregnancy, kidney disease, adrenal tumor, etc. Malignant h.: Can be essential or secondary Diastolic rises very quickly (over weeks or months) High risk for stroke Can be fatal Signs and Symptoms “Silent Killer” Shortness of breath; headache/dizziness; swelling of ankles; sweating, anxiety Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 22 Treatment About 1/3 of people with hypertension who treat it at all, treat it successfully DASH diet Exercise Medication Medications Diuretics Vasodilators to reduce cardiac load Beta blockers, alpha blockers Massage Risks: Clients with advanced or poorly managed hypertension may have serious complications that alter the forms of bodywork that are most appropriate. Also be aware that antihypertensive medications can make people feel fatigued and dizzy: these clients may need extra transition time at the end of a session. Benefits: A client who is encouraged to exercise is generally a good candidate for massage. If activity is limited due to hypertension or heart disease, accommodations can be made to maximize the stress-reduction aspects of massage and minimize any adaptive requirements. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 23 Raynaud syndrome Definition Vasoconstriction of arterioles, usually in hands Can be feet, nose, ears, lips Can be primary (R. disease) Can be secondary (R. phenomenon) Etiology Arterioles in hands, feet: constrict, then dilate Temporary episodes, can become permanent (esp. with R. phenomenon) Types of Raynaud Syndrome Raynaud disease: Primary, freestanding form Triggers include… Stress Cold Mechanical irritation (vibrating machinery) Raynaud phenomenon: Secondary reaction to underlying condition Faster onset, higher risk of complications Causes include… Occlusive arterial diseases Autoimmune connective tissue diseases Drug sensitivities Signs and Symptoms Usually bilateral Cycle of colors: White/ ashy gray Blue Red Episodes last < 1minute-several hours Secondary can be extreme and long-lasting: atrophy, ulcerations, skin and nail damage (Fig. 5.16) Treatment Depends on cause Quit smoking, avoid vasoconstrictors, soak in warm water, dress for weather, protect hands when working in cold, etc. Deal with stress: biofeedback, exercise, massage Medication to dilate blood vessels, counteract norepinephrine Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 24 Surgery: sympathectomy Medications Calcium channel blockers, ACE inhibitors for vasodilation Selective serotonin reuptake inhibitors for peripheral vasodilation Massage Risks: Raynaud syndrome can be a symptom of a serious underlying disorder that requires some adaptation of bodywork. Clients may use vasodilating drugs that also require some changes in bodywork strategies. Benefits: Primary Raynaud disease indicates massage as long as the skin is intact and any medications are accommodated. Options: Many Raynaud syndrome patients enjoy warm hydrotherapy or paraffin baths on the affected areas. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 25 Varicose veins Definition Varix”= “twisted” Valves in superficial veins weaken; vein is stretched, distorted Usually in legs, can be elsewhere Women > men (Fig. 5.17) Etiology In the leg: Small veins pick up blood from internal muscle capillaries Run on superficial aspect, feed into larger veins that perforate leg muscles Muscle contraction/ relaxation moves blood from superficial to deep, and up legs Damage to valves in superficial veins: Wear and tear Standing all day Mechanical obstruction Knee socks, brace, pregnancy Vein becomes enlarged, distorted Complications Varicose ulcers, dermatitis Leg cramps Blood clots (melt easily) Risk of DVT, especially with sudden onset or change in size Types of Varicose Veins Esophageal varices: Large veins at distal end of esophagus Most common with liver disease or bulimia Risk of rupture, internal bleeding Hemorrhoids: Clusters of vascular tissue around the anus Veins, capillaries, small arterioles Can develop inside rectum or externally Associated with constipation, straining during bowel movements Telangiectasias: “Spider veins” Ankles, legs, face Usually harmless; can indicate underlying circulatory problem Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 26 Varicoceles: Dilated venous structures that supply spermatic cord Can be painless Can interfere with fertility, testosterone production Signs and Symptoms Lumpy, bluish wandering lines Protrude from skin Back, medial aspect of calf and thigh Itching, throbbing pain (Fig. 5.18) Treatment Support hose, elastic bandages Avoid long periods on feet, rest with feet elevated Avoid constricting clothes Surgery: Vein stripping Ambulatory phlebectomy Other: Sclerosing injections Laser Radiofrequency Massage Risks: Very extreme veins with skin damage at least locally contraindicate anything but the lightest massage. Be aware that superficial veins have some connectors to deeper veins, which could lead to DVT. Benefits: Massage is unlikely to change v. veins, but flat, gliding pressure toward the heart is safe for this condition as long as the skin is intact and the risk of blood clots is minimal. Options: Mild v. veins can respond to hydrotherapy: alternating hot and cold. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 27 Heart attack Definition Damage to cardiac muscle from ischemia CAD Muscle tissue doesn’t repair; replaced by scar tissue Damaged area = “infarct” Heart attack = myocardial infarction 1.5 million heart attacks in US/year 500,000 deaths #1 COD for men and women (Fig. 5.19) Etiology A portion of myocardium dies due to lack of O2 Usually a blockage in coronary artery Could be clot, debris, that travels from elsewhere Prolonged coronary spasm (drug overdose) New plaques more likely to break off, rupture than old ones Cardiac cells die from ischemia Can’t contract with coordination Related conditions: Atrial, ventricular fibrillations (can be very dangerous) Arrhythmia Embolism Aneurysm Heart failure Shock Signs and Symptoms Angina pectoris Stable Unstable Spreading pain Shortness of breath without chest pain Stomach, abdominal pain It is important to pay attention to early symptoms: heart attacks progressively destroy tissue; early intervention is life-saving. Treatment Identify location of blockage, break it up ASAP Thrombolytics Percutaneous transluminal coronary angioplasty Oxygen, pain management Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 28 Later care: anticoagulants, nitroglycerin, observation, evaluation Surgery if necessary Lifestyle changes Medications Emergency care: Aspirin (anti-platelet) Analgesics Nitroglycerin Thrombolytics, anticoagulants After-care Nitroglycerin Anticoagulants, anti-platelet drugs Cholesterol management drugs Anti-hypertensives Massage Risks: The safety of bodywork in this context depends largely on the adaptive capacity of the client. If activity is limited due to pain or the risk of a repeat event, massage must likewise be limited in its demands on the body. Benefits: Gentle massage for pain and anxiety is helpful even for clients with a recent heart attack. A client with a history of heart problems but who is physically active can probably adapt to any changes that massage might bring about. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 29 Heart failure Definition Progressive loss of heart function Not cardiac arrest 5 million patients in the US 300,000 deaths/year Prevalence doubles with each decade Etiology Heart pumps 2,000 gallons/day If resistance develops, heart compensates Heart grows (cardiomegaly) Ventricles become stiff, inelastic Stress-related hormones boost short-term function, damages in long-term Heart muscle may fibrillate → circulatory system collapse Heart failure usually related to other CV disease Can be related to congenital weakness with heart muscle or valves Types of Heart Failure Left-sided heart failure: Left ventricle pushes against resistance in the aorta (atherosclerosis) Fluid backs up into lungs Causes shortness of breath, coughing, pneumonia risk (Fig. 5.20) Right-sided heart failure: AKA cor pulmonale Resistance on the right side (lungs: could be a complication of leftsided heart failure) Right ventricle is weakened; back-up of fluid accumulates in legs (if ambulatory), abdomen (if bed-ridden) (Fig. 5.21) Biventricular heart failure: Left and right sided failure simultaneously Tends not to respond to medication Patient may be a candidate for transplant surgery See animation and video at thePoint.lww.com/Werner5e Signs and Symptoms Depends on which side of heart is dysfunctional Shortness of breath, low stamina, edema, chest pain, indigestion, arrhythmia, distended vessels in neck, cold sweaty skin… Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 30 Usually slow onset Treatment Depends on location, severity Rest, change in diet, modify physical activity Medications Surgery: repair damaged valves, mesh bag, transplant Medications Anticoagulants Beta blockers, ACE inhibitors Digitalis Diuretics Statins for cholesterol management Massage Risks: Most people with heart failure have a history of other cardiovascular disease, and limitations on physical activities. Massage must likewise be adjusted to fit within those limitations. Be aware the medications to manage heart failure have side effects that must be accommodated for. Benefits: Gentle bodywork that invites (rather than imposes) change may help to reduce blood pressure, decrease stress. Werner, A Massage Therapist’s Guide to Pathology, 5th ed.: Lecture Notes, Ch 5 Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Page 31