THE MINISTRY OF
PUBLIC HEALTH AND
SOCIAL DEVELOPMENT
OF THE RUSSIAN
FEDERATION
P
reventive and clinical medicine
(HERALD OF THE MECHNIKOV
SAINT-PETERSBURG STATE MEDICAL
ACADEMY)
№ 2 (35) 2010
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Preventive and clinical medicine
(Herald of the Mechnikov SaintPetersburg state medical
academy).
2010 № 1 (34), 201 pp.
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42363полугод, 42364-год
Editor-in-chief
Academician of RAMS, Honoured scientist of RF, M.D., Professor
A.V.Shabrov
EDITORIAL BOARD
Academician of RAMS, Honoured Scientist of RF, M.D., Professor
V.G.ARTAMONOVA (Saint-Petersburg), M.D., Professor A.M.BOLSHAKOV
(Moscow), A.A.BORISOV (Saint-Petersburg), Honoured Scientist of RF, M.D.,
Professor V.A.DOTSENKO (Saint-Petersburg), M.D., Professor L.P.ZUEVA
(Saint-Petersburg), M.D., Professor S.I.IVANOV (Moscow), M.D., Professor
A.V.ISTOMIN (Moscow), M.D., Professor V.R.KUCHMA (Moscow), M.D.,
Professor B.V.LIMIN (Vologda), Honoured Scientist of RF, M.D., Professor
V.S.LUCHKEVICH (Saint-Petersburg), Honoured Scientist of RF, M.D.,
Professor
V.G.MAIMULOV
(vice-editor-in-chief,
Saint-Petersburg),
Academician of RAMS, Honoured Scientist of RF, M.D., Professor
G.G.ONISCHENKO (Moscow), Academician of RAMS, Honoured Scientist of
RF, M.D., Professor Yu.Р.PIVOVAROV (Moscow), Academician of RAMS,
Honoured Scientist of RF, M.D., Professor S.N.PUZIN (Moscow),
Academician of RAMS, Honoured Scientist of RF, M.D., Professor,
Yu.A. RAKHMANIN (Moscow), M.D., Professor P.G.ROMASHOV (SaintPetersburg), Academician of RAMS, Honoured Scientist of RF, M.D., Professor
P.I.SIDOROV (Arkhangelsk), Academician of RAMS, Honoured Scientist of
RF, M.D., Professor G.A.SOFRONOV (Saint-Petersburg), Academician of
RAMS, Honoured Scientist of RF, M.D., Professor V.I.STARODUBOV
(Moscow),
M.D.,
Professor
E.I.TKACHENKO
(Saint-Petersburg),
Academician of RAMS, Honoured Scientist of RF, Professor
V.A.TUTELIYAN (Moscow), Honoured Scientist of RF, M.D., Professor
V.P.CHASCHIN (Saint-Petersburg), M.D., Professor T.S.CHERNYAKINA
(executive secretary, Saint-Petersburg)
EDITORIAL COUNCIL
Corresponding member of RAMS, M.D., Professor N.M.ANICHKOV (SaintPetersburg), Candidate of Medicine A.I.VERESCHAGIN (Moscow), M.D.,
Professor L.I.GLUSHKOVA (Syktyvkar), M.D., Professor S.A.GORBANEV
(Saint-Petersburg), M.D., Professor V.A.DADALI (Saint-Petersburg), M.D.,
Professor G.I.DIYACHUK (Saint-Petersburg), Corresponding member of
RAMS, M.D., Professor N.V.Zaitseva (Perm), M.D., Professor A.L.ZELDIN
(Saint-Petersburg), Doctor of Biology, Professor A.L.KOVALENKO (SaintPetersburg),
Corresponding
member
of
RAMS,
Professor
B.A.KURLYANDSKY (Moscow), M.D., Professor S.A.LINNIK (SaintPetersburg), M.D., Professor A.V.MELTSER (Saint-Petersburg), M.D.,
Professor
S.V.NAGORNY
(Saint-Petersburg),
M.D.,
Professor
V.I.NIKOLAEV (Saint-Petersburg), M.D., Professor V.M.PETRENKO (SaintPetersburg), M.D., Professor L.G.PODUNOVA (Moscow), Honoured Scientist
of RF, M.D., Professor I.V.POLYAKOV (Saint-Petersburg), Candidate of
Medicine
I.A.RAKITIN
(Saint-Petersburg),
M.D.,
Professor
V.G.RADCHENKO (Saint-Petersburg), M.D., Professor A.V.Skalny
(Moskow), M.D., Professor E.G.TOPUZOV (Saint-Petersburg), M.D.,
Professor S.A.KHOTIMCHENKO (Moscow), M.D., Professor A.G. SHIMAN
(Saint-Petersburg), Corresponding Member of RAMS, M.D., Professor
A.P.SCHERBO (Saint-Petersburg), M.D., Professor I.Sh.YAKUBOVA (SaintPetersburg)
1
SAINT-PETERSBURG – 2010
CONTENTS
PUBLIC HEALTH AND PUBLIC HEALTH SERVICES
Eremin G.B., Yakubova I.Sh., Maimulov V.G., Chernyakina T.S., Suvorova
A.V., Blinova L.T., Petrashevich V.A. Problems of quality support in medical aid
organization for children and adolescents in educational establishments
Orel V.I., Keshishev I.A. Structural bases of
disabled children complex
rehabilitation
Shestakov V.P., Svintsov A.A., Chernyakina T.S., Ovcharenko S.A., Chepik K.V.
Analysis of dynamics of primary disability of the population of the Russian
Federation due to craniocerebral injury
Paskar N.A., Karuzin S.V., Polyakov I.V., Alborov A.H.,
Arbuzova Y.M.,
Kulikov V.D. The characteristic of morbidity and mortality rate of adult population of
Saint-Petersburg because of illnesses of blood circulation system
MOTHER AND CHILDHOOD PROTECTION
Degtyaryova Е.А., Romantsov M.G., Zhdanova O.I., Mikheeva А.А., Avakyan
А.А. Cytoflavin as a means for the correction of posthypoxic myocardial lesions in
newborn infants
Abdurakhimova K.Sh. Integral evaluation of enterobiasis risk factors
importance and risk group formation in preschool children
HYGIENE OF THE SURROUNDING AND INDUSTRIAL ENVIRONMENT
Kovtunova M.E., Pozdeev N.M., Kashin K.P., Kunof V.K. Seasonal influence
on the parameters of protein metabolism in donors of plasma for fractionation
Nekhoroshev A.S., Danilova N.B., Morozova E.I. Methodological aspects of the
use of training programs on hygiene of oral cavity physician-stomatologists
practitioners
2
Navruzov E.B. Reproductive system hormones content in rats at the hossipole
intoxication
Usmanova Sh.F. Microenvironmental problems of medical nurses in clinical
subdivisions
NEW TECHNOLOGIES, METHODS OF DIAGNOSTICS, TREATMENT
AND PREVENTION IN PUBLIC HEALTH SERVICES
Gontar I.P., Nenasheva N.V., Matasova N.A., Avetisova E.R., Kochneva L.I.,
Zborovskaya I.A. Clinical-diagnostic value of determination of antibodies to elastin
and elastase in patients with rheumatic arthritis, systemic lupus erythematosus,
systemic scleroderma
Orlov A.Yu., Kokin G. S., Daminov R. G., Komkov D.Yu., Berishvili K.Sh.
Methods of examination of patients with peripheral nerve tumors
Grenkova Yu.M., Safronova M.M. Modern approaches to diagnostics of uterine
cervix diseases in post menopause
Ibragimov Sh.I., Abdullaev T.U. HLA-antigen association with climacteric
keratoderma
Nilova L.Yu., Orishak E.A., Boitsov A.G. Regarding the problem of probiotics
usage for intestinal disbacteriosis therapy
CLINICAL AND EXPERIMENTAL STUDIES
Belkov A.V., Russin A.S., Sadique M. I., Kolesnichenko M.G., Burbello A.T.
Clinical prognostic value of metabolic treatment in patients with myocardial
infarction
Gorbacheva I.A., Sycheva Yu.A., Slepneva L.V., Alekseeva N.N., Malozemova
V. A, Popov D.A. Antihypoxic therapy resources in ischemic heart treatment
Livanov
G.A,
Amagyrov
V.P.,
Batotsyrenov
B.V.,
Lodyagin
A.N.,
Batotsyrenova H.V. Metabolic distress correction in complicated forms of myocardial
infarction
3
Frolova N.L.1 Features of autonomic regulation of heart rate in cardiac patients
with psychosomatic profile
Kozyrev A.G., Surkova E.A., Gichkin A.Yu., Perley V. E. Endotelin-1content in
patients with bronchial asthma with concomitant hypertensive disease
Goldzon M.A., Dolgikh V.T., Girsh A.O. Contractile rat myocardial function
disorders at thermal trauma and ways of their correction
Belova S.V. Simulation of experimental arthritis
Tarasov A.N. Pancreas graft formation depending on conditions of its blood
supply
Komyakov B. K., Guliev B. G., Shibliev R. G., Alekseev M. Yu. Complications
of percutaneous nephrolithotripsy
Alexandrova L.A., Zhloba A.A., Blashko E.L., Chefu S.G. Kuzmenko N.V.,
Tsirlin V.A. Methabolism of aminothiols and antioxidant status in rats under
experimental renal ischemia
Belokrylov Н.М. Choice of optimum tactics for treatment of Legga-KalvePertes disease
Arsenev A.A., Dmitriev B. V., Makarov V. K. Immunoreactivity features in
patients with benign prostate hyperplasia and prostate adenocarcinoma
Seliverstov P.V., Teterina L.A., Radchenko V.G., Sitkin S.I., Suvorov A.N.,
Alekhina G.G. Aged changes in the gastrointestinal tract in patients with disbiosis of
the large intestine on the background of liver chronic diseases
Abdulaev M.A., Plotnikov Yu.V., Mukhanna A.M. Еarly results of treatment of
patients with perforated gastroduodenal ulcers
Chuprov I.N., Klyucharyova S.V. Romanova V.L
Parenchymal basal
membrane in various types of the skin basal cell carcinoma
Slepnev M.V., Frolova N.Yu. Study of pharmacological activity of ointments,
obtained on the basis of the gel – Arespol
Komleva N.E, Spirin V.F, Grishina T.V, Novikova T.A, Medentsov V.A,
Mikhailova N.A, Skvortsov V.O Influence dorsopatiya of agricultural workers on
quality of life
4
EPIDEMIOLOGY, MICROBIOLOGY, INFECTIOUS AND PARASITIC
DISEASES
Kargaltseva N.M.,Burbello A.T., Kocherovets V.I., Fedorenko A.S. Clinical and
microbiological features of blood flow infections
Aleksandrova E.A., Lepilin A.V., Kazimirova N.E., Shuldyakov A.A. Cycloferon
liniment efficiency study in the complex therapy of oral cavity inflammatory diseases
in tuberculous patients
Khalikova Sh.A., Daminova M.N. Amino acid spectrum and nitrogen oxide
state in blood serum of children with chronic virus hepatitis C
RESTORATIVE MEDICINE
Burmistrov D.A., Demin G.S., Khardikov O.I.
Strong
training by STEN
method as a way to restore flexibility and reduce pain syndrome in patients with
lumbosacral osteochondrosis in different ages
Gzogyan M.N., Tarasov N.I., Isakov L.K., Krivonosov D.S., Kuznetsova T.V.,
Yarkovskaya A.P., Teplyakov A.T. The effectiveness of rehabilitation measures with
long-standing physical training in outpatient recovery in patients after myocardial
infarction
MEDICAL PSYCHOLOGY, PSYCHIATRY, PSYCHOTHERAPY
Belov V.G., Parfenov Yu.A., Dergunov A.A., Orlovsky M.S. Art therapy in
treatment of non-psychotic affective distresses
Vlasova O.L. Clinico-psychological features of patients with a various clinical
versions of current of a metabolic syndrome
SCIENTIFIC REVIEWS
Romantsov M. G., Goryacheva L.G., Kovalenko A.L. Pharmaco-therapeutic
cycloferon efficacy in pediatric practice
Petrova N.N. Medical products for pharmacological correction of sensorineural
hearing loss
5
Sologub T.V., Romantsov M. G, Semenyako N.A., Kovalenko S.N., Kovalenko
A.L., Sukhanov D.S. Modern approaches to HCV-infection treatment
TO AUTHORS ATTENTION
PUBLIC HEALTH AND PUBLIC HEALTH SERVICES
1256 Еремин+
UDC 613.955/.956:614.39
© G.B. Еremin, I.Sh. Yakubova, A.V. Suvorova, V.G. Maimulov,
T.S. Chernyakina, L.T. Blinova, V.A. Petrashevich, 2010
Eremin
G.B.1,
Yakubova
I.Sh.1,
A.V.1,
Suvorova
Maimulov
V.G.1,
Chernyakina T.S.1, Blinova L.T.1, Petrashevich V.A.2 Problems of quality support in
medical aid organization for children and adolescents in educational establishments //
Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
1
State Educational Establishment of Higher Professional Training «Mechnikov
Sankt-Petersburg State Medical Academy of the Federal Agency for Public Health
and Social Development of the Russian Federation». Russia, 195067, SaintPetersburg, K-67, Piskarevsky pr., 47. Tel.: 8(812)543-96-09, fax: 8(812)740-15-24,
e-mail: mechnik@westcall.net; www.mechnik.spb.ru
2
Municipal policlinic N 88, Russia, 198261, Saint-Petersburg, General
Simonyak str., 6, tel.: 8(812)750-80-11, fax: 8(812)750-9246.
S u m m a r y : The article deals with the problems of quality in medical help
organization to children and adolescents in educational establishments. Components
of medical aid are specified. Problems of development of medical standards aid to
children and adolescents in educational establishments are set.
Key
words:
children,
adolescents,
medical
aid,
educational
establishments
Information about the authors:
6
Eremin Gennady Borisovich – Candidate of Medical Sciences, head of the
branch of the FSI «Consultation-methodical center for licensing» of the Federal
service on Public health and social development in Saint-Petersburg and Leningrad
region», Russia, 191311, Saint-Petersburg, Smolny str. 3, let. А. Tel.: 8(812)576-7990. E-mail: yeremin45@rambler.ru
Yakubova Irek Shavkatovna - Doctor of Medicine, Professor of the department
of Preventive Medicine and Health Protection of the Mechnikov Saint-Petersburg
State Medical Academy, work tel./fax: 8(812)543-17-47, mobile phone: 8(921)96504-89. E-mail: yakubova-work@yandex.ru
Suvorova Anna Vasilievna - Candidate of Medical Sciences, AssistantProfessor of the department of Preventive Medicine and Health Protection of the
Mechnikov Saint-Petersburg State Medical Academy, work tel./fax: 8(812)543-1747, mobile phone: 8(911)755-7910. E-mail: suvorova-work@mail.ru
Maimulov Valery Georgievich – Honoured scientist, M.D., Professor, head of
the department of Preventive Medicine and Health Protection of the faculty for
Advanced Training of the state educational establishment for higher professional
training “I.I.Mechnikov Saint-Petersburg State Medical Academy» of the Federal
agency for Public Health and Social Development of the Russian Federation”, Russia,
195067, Saint-Petersburg, К-67, Piskarevsky prospect, 47 Tel. 8(812)543-96-09, fax:
8(812)140-15-24, e-mail: mechnik@gmail.com
Chernyakina Tatiyana Sergeevna – M.D., Professor of the department of
Preventive Medicine and Health Protection of the Faculty for Advanced Training of
the SEE HPT «SPSMA named after I.I.Mechnikov of Roszdrav», tel.: (812)543-4941, fax: (812)543-93-18. E-mail: mаimulov@gmail.com
Blinova Lyubov Timofeevna - Candidate of Medical Sciences, AssistantProfessor of the department of Preventive Medicine and Health Protection of the
Mechnikov Saint-Petersburg State Medical Academy, work tel./fax: 8(812)543-1747, mobile phone: 8(911)119-90-71. E-mail: ozdpprormed@mail.ru
7
Petrashevich Vladimir Alekseevich – Candidate of Medical Sciences, chief
physician of the municipal polyclinic № 88, Russia, 198261, Saint-Petersburg,
General Simonyan str., 6. Yel.: 8(812)750-80-11, fax: 8(812)750-92-46.
M a t e r i a l R e c e i v e d 28.11.2009 г.
8
1334 Орел+
UDC 34:616-036.868
© V.I. Orel, I.A. Keshishev, 2010
Orel V.I.¹, Keshishev I.A.² Structural bases of
disabled children complex
rehabilitation // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
¹Saint-Petersburg State Pediatric Medical Academy, Russia, Saint-Petersburg,
194100, Litovskaya str., 2. Phone: 295-06-46, 542-39-83, fax: 295-40-85. E-mail:
spb@gpma.ru
²Children Rehabilitation Center, Russia, Saint-Petersburg Federal State
Institution the «Saint-Petersburg Scientific-Practical Center for Disabled Medical and
Social Examination, Prosthetics and Rehabilitation named after G.A.Albrekht of the
Federal Agency for Public Health and Public Health Services»: Russia, SaintPetersburg, 195067, Bestuzhevskaya str., 50. Phone: 8(812)544-22-66, 544-13-26. Email: reabin@nkl.ru, Web-address: http: //reabin.sp.ru
S u m m a r y : The article contains practical bases in complex rehabilitation
of disabled children, including medical, professional, psychological-and-pedagogical,
social rehabilitation.
K e y w o r d s : disabled children; complex rehabilitation measures.
Information about the authors:
Orel V.I. – head of the department of «Social Pediatrics and Public Health
Organization» of FAT and RT of the Saint-Petersburg State Pediatric Academy,
Saint-Petersburg.
Keshishev I.A. – doctor in children rehabilitation-restoration center of FSI
«A.A. Albrekht Saint-Petersburg Scientific-Practical Center of Medical-Social
Examination, Prosthetics and Rehabilitation of Disabled of the Federal MedicalBiological Agency of the Russian Federation». Tel.: 8(812)544-22-66, 544-13-26, Email: reabin@nkl.ru.
M a t e r i a l R e c e i v e d 10.06.2010 г.
9
1253 Шестаков+
UDC 614.1-056.266/.267:616.714-001:616.831-001
© V.P. Shestakov, A.A. Svintsov, T.S. Chernyakina, S.A. Ovcharenko, K.V. Chepik,
2010
Shestakov V. P, Svintsov A.A., Chernyakina T.S., Ovcharenko S.A., Chepik К.V.
Analysis of primary physical inability dynamic parameters due to craniocerebral
trauma // Preventive and Clinical Medicine. – 2010. - № 2 (35). – P.
Federal state institution «G.A. Albrekht St.-Petersburg Scientific-Practical
Centre for Medical-Social Examination, Prosthetics and Rehabilitation of Invalids of
the
Medical
Bestuzhevskayay
and
str.,
Biologic
50.
Agency»:
Tel.:
+7(812)
Russia,
195067,
544-22-66,
St.-Petersburg,
544-13-26.
E-mail:
reabin@nkl.ru.
S u m m a r y : Рurpose of the study – to define and estimate the dynamics of
prevalence of primary physical inability of citizens due to craniocerebral trauma
depending on a place of residence, age and physical inability group. Material: Results
of the primary examination of citizens (Russian Federation) at the age of 18 and over
because of consequences of head injuries (Class MKB-10 Т90) for the period of
2005-2008. Methods: Statistical analysis of primary physical inability parameters.
Results: Figures for primary physical inability as a consequence of craniocerebral
trauma were higher in countryside, than in urban settlements and than on the average
across the Russian Federation. The maximum level was registered among middle
aged persons, and minimum – in persons of advanced age. The highest figures were
registered in II and III groups of physical inability. In Siberian and Far East Federal
districts (FD) the parameter of primary physical inability of I group was above the
mean parameter across the Russian Federation in all the analyzed years, II group - in
Southern and Siberian FD, III group - only in Southern FD. The figures for primary
physical inability of II and III groups considerably exceeding those across the
Russian Federation were in the Chechen republic. For 4 years the level of primary
physical inability both across the Russian Federation, and also in urban settlements
and countryside, as well as in all federal districts, age groups and physical inability
groups decreased. The obtained statistical data on physical inability of various groups
10
of the population due to craniocerebral trauma can serve a basis for the development
of regional and nation-wide programs of rehabilitation, for planning of regularlypersonnel structure and equipment of the establishments realizing individual
programs of invalids rehabilitation.
K e y w o r d s : craniocerebral trauma; primary physical inability dynamic
prevalence; distribution due to a place of residence; age and physical inability groups.
References
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Information about the authors:
Shestakov Vladimir Petruvich – Doctor of Medical Sciences, Deputy-director
of the Federal State Institution the «Saint-Petersburg Scientific-Practical Center for
Disabled Medical and Social Examination, Prosthetics and Rehabilitation named
after G.A.Albrekht of Roszdrav». FSI the “Saint-Petersburg Scientific-Practical
Center for Medical-and-Social Examination, Prosthetics and Rehabilitation of
Disabled named after G.A.Albrekht of Roszdrav. Рhone: +7 (812) 544-22-66, 54413-26. E-mail: reabin@nkl.ru.
12
Svintsov Alexander Anatolievich – Candidate of Medical Sciences, head of the
department of the Federal State Institution the «Saint-Petersburg Scientific-Practical
Center for Disabled Medical and Social Examination, Prosthetics and Rehabilitation
named after G.A.Albrekht of Roszdrav». Tel.: +7 (812) 544-22-66, 544-13-26. Email: reabin@nkl.ru.
Chernyakina Tatiyana Sergeevna – Doctor of Medicine, Professor of the
department of Preventive Medicine and Health Protection of the Faculty for
Advanced Training of the SEE HPT «Mechnikov Saint-Petersburg State Medical
Academy of Roszdrav», tel./fax: (812)543-49-41, tel. home: 8(812) 525-59-47, tel.
mob.: 8-950-028-61-93. E-mail: mаimulov@gmail.com
Ovcharenko Svetlana Alekseevna – Doctor of Medicine, Professor, head of the
department «Theory and Practice of Social Work» Saint-Petersburg State University
of service and economic. Tel. work.: 8(812) 252-18-97, tel. home: 8(813) 702-45-04,
tel. mob.: 8-921-974-00-98. E-mail: Kafedra_TiPSR@list.ru
Chepic Kirill Vladimirovich – senior researcher of the Federal State Institution
“Albrekht
Saint-Petersburg
Scientific-Practical
Center
of
Medical-Social
Examination, Prosthetics and Rehabilitation of the disabled of the Federal Madicaland-Biological
Agency”
Теl.:
+7
(812)
544-22-66,
544-13-26.
E-mail:
reabin@nkl.ru.
M a t e r i a l R e c e i v e d 24.11.2009 г.
1336 Паскарь +
UDC 614.1:616.1 (470.23)
© N.A. Paskar, S.V. Karuzin, I.V. Polyakov, A.H. Alborov, Y.M. Arbuzova,
V.D. Kulikov, 2010
Paskar N.A.1, Karuzin S.V.1,2 Polyakov I.V.2, Alborov A.H.3, Arbuzova Y.M.3,
Kulikov V.D.3 The characteristic of morbidity and mortality rate of adult population
of Saint-Petersburg because of illnesses of blood circulation system // Preventive and
clinical medicine. – 2010. - № 2 (35). – Р.
1
Federal State Establishment «Federal Centre of Heart, Blood and
Endocrinology of V.A. Almazov, Rosmedtehnology». Russia, 197341, Saint13
Petersburg, Accuratova str., 2. Tel/fax: 8(812)702-37-00. E-mail: director@hbecentre.ru; www.almazovcentre.ru
2
State Educational Establishment of Higher Professional Training «Mechnikov
Sankt-Petersburg State Medical Academy of the Federal Agency for Public Health
and Social Development of the Russian Federation». Russia, 195067, SaintPetersburg, K-67, Piskarevsky pr., 47. Tel.: 8(812)543-96-09, fax: 8(812)740-15-24,
e-mail: mechnik@westcall.net; www.mechnik.spb.ru
3
Saint-Petersburg
State
Medical
Establishment
«Medical
information-
analytical centre». Russia, 198095, St.-Petersburg, Shkapina str., 30. Tel.: 8(812)57622-22, fax: 8(812)576-22-23 E-mail: mail@miac.zdrav.spb.ru
S u m m a r y : From the beginning of 1990th years illnesses of blood
circulation system continue remain leaders in morbidity and mortality structure. The
basic damage put cerebrovascular diseases, diseases characterised by the raised blood
pressure and an ischemic heart trouble to health of the Russian population.
K e y w o r d s : illnesses of blood circulation system; morbidity; mortality;
quality of a life.
References
1. Демографический ежегодник России. - М., 2008. - С. 306-312.
2. Регионы России. Социально-экономические показатели. - М., 2008. - С.
60-62, 316-317.
3.
Регионы
Северо-Западного
Федерального
округа.
Социально-
экономические показатели, 2007 год. Статистический сборник. – Сыктывкар:
Комистат, 2007. - 182 с.
4. Российский статистический ежегодник. - М., 2008. - С. 112-116.
5. Социально-значимые заболевания населения России в 2006 году.
Статистические материалы. - М., 2007. - 67 с.
Information about the authors:
Paskar Nadezhda Andreevna - candidate of medical sciences, head of
Department of rendering hi-tech medical aid with group of an estimation quality of
14
hi-tec medical aid Federal State Establishment «Federal Centre of Heart, Blood and
Endocrinology of V.A. Almazov, Rosmedtehnology». Work tel.: 8(812)702-55-82.
Karuzin Sergey Vyacheslavovich - the internal post-graduate student of the
Course of Management and Economy of Public Health Services of Department
Socially-Humanities Science, Economy and Low of Saint-Petersburg State Medical
Academy named after I.I. Mechnikov. The initial scientific employee of Department
of rendering hi-tech medical aid with group of an estimation quality of hi-tec medical
aid Federal State Establishment «Federal Centre of Heart, Blood and Endocrinology
of V.A. Almazov, Rosmedtehnology». Work tel.: 8(812)543-02-64.
Polyakov Igor Vasilevich - doctor of medicine, professor, head of the Course
of Management and Economy of Public Health Services of Department SociallyHumanities Science, Economy and Low of Saint-Petersburg State Medical Academy
named after I.I. Mechnikov. Work tel.: 8(812)543-02-64.
Alborov Alan Hsarbegovich – director of St.-Petersburg State Medical
Establishment «Medical information-analytical centre». Ph. 8(812)576-22-22, a fax:
8(812)576-22-23.
Arbuzova Yulia Mikhaylovna – engineer of department of analysis and
forecasting of St.-Petersburg State Medical Establishment «Medical informationanalytical centre». Ph. 8(812)576-22-37, a fax: 8(812)576-22-23.
Kulikov Valery Dmitrievich – candidate of medical sciences, manager of
department of analysis and forecasting of St.-Petersburg State Medical Establishment
«Medical information-analytical centre». Ph. 8(812)576-22-75, a fax: 8(812)576-2223.
M a t e r i a l R e c e i v e d 23.06.2010 г.
MOTHER AND CHILDHOOD PROTECTION
1327 Дегтярева+
UDC 616.12-053.31:615.27
© Е.А. Degtyaryova, M.G. Romantsov, O.I. Zhdanova, А.А. Mikheeva,
А.А. Avakyan, 2010
15
Degtyaryova Е.А.1, Romantsov M.G.2, Zhdanova O.I.1, Mikheeva А.А.3,
Avakyan А.А.3 Cytoflavin as a means for the correction of posthypoxic myocardial
lesions in newborn infants // Preventive and clinical medicine. – 2010. - № 2 (35). – P
1
Russian University of People Friendship (RUDN), Russia, 117198, Moscow,
Miklukho-Maklay str. 6.
2
Scientific-Technological Pharmaceutical Firm «POLYSAN», Russia, 191119,
Saint-Petersburg, Ligovsky prospect, 112, tel.: 8(812)110-82-25,112-13-79, е-mail:
sales@polysan.ru, STPF “POLYSAN” www.polysan.ru
3
State educational institution of the higher professional training Roszdrav
Russian State Medical University (SEE RSMU ), Russia, 117997, Moscow,
Ostrovetyanova str., tel.: 8 (495) 434-03-29, e-mail: rsmu@rsmu.ru
S u m m a r y : A multicenter trial of 30 infants with post-hypoxic myocardial
lesions associated with I-II degree cerebral ischemia has revealed that the inclusion of
Cytoflavin infusions into the complex standard treatment leads, besides the
improvement of general clinical status, to significantly more rapid, as compared to
the control group, positive dynamics of pump and contractile myocardial functions,
elimination of hyperfermentemia, hypoxia and electrical instability of the
myocardium, energetic deficit, repolarization changes within the first 5 days of inhospital therapy as well as during the follow-up from 1 to 6 months of life.
K e y w o r d s : cytoflavin; ischemia-hypoxia; newborn infants; myocardium.
References
1. Афанасьев В.В. Цитофлавин в интенсивной терапии / В.В. Афанасьев //
Пособие для врачей. – СПб., 2005. – 36 с.
2. Визир В.А. Метаболические кардиомиопротекторы: фармакологические
свойства и применение в клинической практике / В.А. Визир, И.Н. Волошина,
Н.А. Волошин // Методические рекомендации. – Запорожье, 2006. – 34 с.
3. Ланкин В.З. Свободнорадикальные процессы в норме и при
патологических состояниях / В.З. Ланкин, А.К. Тихазе, Ю.Н. Беленков //
Пособие для врачей. Издание второе, исправленное и дополненное. М.:
Медицина, 2001. – 78 с.
16
4. Прахов А.В. Функциональное состояние сердца у новорожденных детей
с различными вариантами сочетанной перинатальной патологии / А.В. Прахов,
Ж.В. Альбицкая, Ю.Д. Гиршович // Детские болезни сердца и сосудов. – 2004. № 3. – С. 60-63.
5. Симонова Л.В. Постгипоксический синдром дезадаптации сердечнососудистой
системы
у
новорожденных
и
детей
раннего
возраста
/
Л.В. Симонова, Н.П. Котлукова, М.Е. Ерофеева // Педиатрия. – 2000. - № 3. С. 17-21.
6. Таболин В.А. Актуальные проблемы перинатальной кардиологии /
В.А. Таболин, Н.П. Котлукова, Л.П. Симонова // Педиатрия. - 2000. - № 5. С. 13-22.
7. Costa S. Serum troponin T usefull of myocacardial damage in newborn
infants with perinatal asphexia / S. Costa, E. Zecca //Acta Paediatrica. – 2007. –
Vol. 96. – Р. 181-185.
8. Clark S.G. Concentration of cardiac troponin T in neonates with and without
respiratory distress / S.G. Clark, Р. Newland, C.W. Yoxall // Arch Dis Child Fetal
Neonatal Ed. – 2004. - Vol. 89. – Р. 348-352.
9. Eques J. Myocardial infarction in relation to perinatal hypoxia // J. Eques,
V. Flores, M. Mendivil // AN Esp. Pediatr. – 1983. – Vol. 19, №4. – P. 263-267.
10. Muller J.C. Value of myocardial hypoxia markers (CK and its MB-fraction,
troponin T, Q-T interval) and serum creatinine for the retrospective diagnosis of
perinatal asphyxia / J.C. Muller, В. Thielsen // Biology neonate. – 1998. - Vol. 73. –
Р. 367-374.
11. Rowe R.D. Transient myocardial ischemia of the newborn infant-form of
severe cardiorespiratory distress in full term infants / R.D. Rowe, T. Hoffman // J.
Pediatr. – 1972. - Vol. 81. – Р. 234-250.
12. Sharma R. The role of inflammatory mediators in chronic heart failure:
cytokines, nitric oxide, and endothelin-1 / R. Sharma, A.J. Coats, S.D. Anker // Int. J.
Cardiology. – 2000. – Vol. 72, № 2. – P. 175-186.
17
13. Tiernan C.F. The role of tumor necrosis factor alpha in the
pathophysiology of congestive heart failure / C.F. Tiernan, A.M. Feldman // Curr.
Cardiol. Rep. – 2000. – Vol. 2, № 3. – P. 189-197.
Information about the authors:
Degtyareva E.A. - Doctor of Medicine, Professor of the department of Children
Diseases of RUDN, chief physician of children infectious clinical hospital №6,
Moscow, Vice-President of the Association of Children Cardiologists of Russia.
Romantsov Mikhail Grigorievich – Doctor of Medicine, Professor of the
department of Infectious Diseases of SEEHPT «Saint-Petersburg State Medical
Academy named after I.I.Mechnikov of Roszdrav», chief adviser for scientific work
of the Open Company NTFF «POLYSAN». Тel.: 8-812-710-82-25. E-mail:
RomantsovGCP@polysan.ru
Zhdanova Olga Ivanovna - Candidate of Medical Sciences, Assistant of the
department of Children Diseases of RUDN.
Mikheeva Anna Anatolievna - Candidate of Medical Sciences, Assistant of the
department of children diseases №3 of RSMU, deputy-head physician for medical
work CICH №6. Tel.: 8(495) 456-34-71.
Avakyan Alexander Armenovich – Assistant of the department of children
Disease of the Medical faculty of RSMU, deputy-head physician for medical work
CICH №6. Tel.: 8(495) 456-34-71.
M a t e r i a l R e c e i v e d 01.06.2010 г.
1308 Абдурахимова+
UDC 616.995.1:616-02-053.4
© K.Sh. Abdurakhimova, 2010
Abdurakhimova K.Sh. Integral evaluation of enterobiasis risk factors
importance and risk group formation in preschool children // Preventive and clinical
medicine. – 2010. - № 2 (35). – Р.
Tаshkent Medical Aсademy, Ministry of Health of the Republic of Uzbekistan,
100109, Uzbekistan, Tаshkent, Faroby str., 2, Tel: +998 (71) 1507825, 2148311; Fax:
+998 (71) 2185948, E-mail: info@tma.uz; tta2005@mail.ru
18
S u m m a r y : It has been calculated prognostic risk tables that can be used in
practical purposes to determine the chance of enterobiasis occurrence at the age of 3
until 7 years old. Proposed tables can be used in realization of preventive and sanitary
measures to eliminate and reduce the effect of revealed unfavourable factors.
K e y w o r d s : children with enterobiasis; risk factor; risk group.
References
1. Маркин А.В. Формирование групп риска среди детей дошкольного
возраста при энтеробиозе / А.В. Маркин // Гиг.и сан. - 1991. -№ 2. – С. 64-67.
2. Пономарева Л.А. Прогнозирование показателей здоровья населения на
основе интегрированной оценки значимости факторов среды обитания человека
(методические
рекомендации)
/
Л.А. Пономарева,
Б.М. Маматкулов,
Ю.Ю. Ассесорова // Ташкент, 2009. - 16 с.
3. Шиган Е.Н. Методы прогнозирования и модемирования в социальногигиенических исследованиях / Е.Н. Шиган. – М.: Медицина, 1986. – 207 с.
Information about the author:
Abdurakhimova Kamola Shahobutdinovna - рost-graduate at the department of
children, teenagers and nutrition hygiene in the Tаshkent Medical Aсademy. Tel.:
+998 (71) 214-84-11.
M a t e r i a l R e c e i v e d 31.03.2010 г.
HYGIENE OF THE SURROUNDING AND INDUSTRIAL
ENVIRONMENT
1306 Ковтунова+
UDC 615.38:611.018.54:612.015.348-07«32»
© M.E. Kovtunova, N.M. Pozdeev, K.P. Kashin, V.K. Kunof, 2010
Kovtunova M. E., Pozdeev N.M., Kashin K.P., Kunof V.K. Seasonal influence on
the parameters of protein metabolism in donors of plasma for fractionation //
Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
19
Federal State Institution «Kirov Research Institute of Hematology and Blood
Transfusion of the Federal Medical Biological Agency of Russia». Russia, 610027,
Kirov, Krasnoarmeyskaya str., 72. Теl.: 8(8332) 54-97-31, Fax: 8(8332) 54-97-31. Email: mkovtunova@yandex.ru
S u m m a r y : To estimate the influence of a seasonal factor on the content of
the total protein and protein fractions in plasma donors for fractioning we analyzed
their dynamics among 341 persons (male and female) aged from 18 to 65. Based on
the results of one-factor disperse analysis we established seasonal changes of the
following figures of protein metabolism: albumin, the sum of globulins, β1-globulins
and β2-globulins – among male and female, as well as γ-globulins among female.
The influence of a seasonal factor was mostly observed in globulin-components,
especially among female donors.
Key
w o r d s : seasonality indices of protein metabolism; donation of
plasma for fractionation.
A serious shortage of medical preparations is seen at the present time in Russia.
The lag of blood service production complexes behind the international experience,
on the one hand, the lack of sufficient resources for medical prophylactic
establishments, on the other hand, are responsible for that (1,2). In new category of
donors designed for fractionation has been introduced according to the Russian
ministry of Health and Social development order in № 175n of 16.07.2008. It is a
specialized donation of plasma intended exclusively for production purposes.
Blood plasma plays an important part in the maintenance of homeostasis in the
human organism, it ensures a constant volume of liquid in the blood vessels,
transportation of different substances arriving in the blood, neutralization and
removing of metabolites. The protein composition of the plasma for manufacturing
preparations must correspond to the appropriate requirements. Production of
preparation out of donor blood and its components is a major problem facing modern
transfusiology. Blood preparations are most important for treating patient with severe
diseases accompanied by loss of protein.
20
It is well known that a person consumes more meat foods in the winter and early
spring and more vegetables and fruit in the summer and early autumn/ Investigation
of indices for protein metabolism in the donors of plasma for transaction and
depending on the season was of scientific and practical interest.
The purpose of investigation was evaluation of the general protein level and its
fractions during different seasons.
M a t e r i a l s a n d m e t h o d s o f t h e i n v e s t i g a t i o n . 341 donors of
plasma for fractionation, i.e. 199 males and 142 females aged 18 through 65 years
were examined. Laboratory studies were carried out in accordance with the Russian
ministry of Public Health Order № 364 “On ratification of procedure for medical
examination of donors of blood and its components” in the wording of the Russian
ministry of Public Health and Social Development Order from 16.04.2008, the
number 175n. The studies included determination of the general protein levels and its
fractions: albumin, aggregate globulins, 1- globulins, 1- globulins, 2- globulins
and – globulin. Statistical processing of the results was performed using regressive
and single-factor dispersion analysis.
R e s u l t s o f t h e i n v e s t i g a t i o n a n d d i s c u s s i o n . Statistical analysis of
indicates for the four seasons (winter, spring, summer, autumn) was made in separate
male and female groups. The registered levels of albumin, aggregate globulins, 1globulins, 1- globulins, 2- globulins and – globulins were in all donors within the
range of normal indices. A comparative avaluation of the seasonal factor effect on the
protein composition of the plasma in males and females revealed certain regularities.
The following table shows the results obtained in the investigation of the protein
metabolism in the donors of plasma for fractionation depending on the season.
Table
Indices for protein metabolism in the donors of plasma for fractionation
Males
Season
n
M
m
Females
s
V
n
M
21
69,1
m
s
V
1,89
8,66
12,5%
General proteins
Winter
22
65,93
1,26
6,91
10,5%
21
Spring
45
66,98
0,87
5,85
8,7%
40
67,65
1,19
7,53
11,1%
Summer
60
67,45
0,81
6,25
9,3%
31
69,42
1,14
6,37
9,2%
Autumn
72
68,97
0,82
6,99
10,1%
56
69,45
0,99
7,44
10,7%
Albumin
Winter
22
59,61
0,41
2,22
3,7%
21
57,3
1,4
6,4
11,2%
Spring
45
60,41
0,26
1,76
2,9%
40
58,69
0,44
2,77
4,7%
Summer
60
58,95
0,34
2,67
4,5%
31
56,33
0,57
3,17
5,6%
Autumn
72
59,25
0,31
2,59
4,4%
56
58,26
0,41
3,05
5,2%
Aggregate globulins
Winter
22
40,39
0,41
2,22
5,5%
21
42,66
1,02
4,66
10,9%
Spring
45
39,61
0,26
1,74
4,4%
40
41,02
0,39
2,5
6,1%
Summer
60
41,05
0,34
2,67
6,5%
31
43,67
0,57
3,17
7,3%
Autumn
72
40,68
0,31
2,58
6,3%
56
41,71
0,4
2,97
7,1%
α1- globulins
Winter
22
3,6
0,08
0,44
12,2%
21
3,58
0,13
0,57
15,9%
Spring
45
3,6
0,06
0,4
11,1%
40
3,61
0,06
0,39
10,8%
Summer
60
3,67
0,07
0,5
13,6%
31
3,62
0,11
0,62
17,1%
Autumn
72
3,6
0,07
0,6
16,7%
56
3,69
0,05
0,39
10,6%
α2- globulins
Winter
22
9,03
0,26
1,42
15,7%
21
9,29
0,25
1,16
12,5%
Spring
45
9,01
0,17
1,11
12,3%
40
8,91
0,14
0,9
10,1%
Summer
60
8,97
0,19
1,44
16,1%
31
8,61
0,18
1,01
11,7%
Autumn
72
8,79
0,14
1,16
13,2%
56
8,96
0,15
1,11
10,6%
12,5% 21
5,77
0,14
0,65
11,3%
β1- globulins
Winter
22
5,61
0,13
0,7
Spring
45
5,76
0,09
0,59
10,2%
40
5,88
0,09
0,54
9,2%
Summer
60
5,54
0,07
0,53
9,6%
31
6,18
0,15
0,84
13,6%
Autumn
72
5,96
0,08
0,72
12,1%
56
6,26
0,07
0,54
8,6%
β2- globulins
Winter
22
9,27
0,22
1,18
12,7%
21
9,59
0,34
1,57
16,4%
Spring
45
8,9
0,17
1,15
12,9%
40
9,09
0,18
1,15
12,7%
22
Summer
60
9,91
0,12
0,96
9,7%
31
10,1
0,22
1,24
12,3%
Autumn
72
9,77
0,16
1,34
13,7%
56
9,71
0,14
1,05
10,8%
γ - globulins
Winter
22
12,88
0,38
2,06
16,0%
21
14,43
0,65
2,98
20,7%
Spring
45
12,36
0,21
1,38
11,2%
40
13,68
0,33
2,09
15,3%
Summer
60
12,95
0,27
2,09
16,1%
31
15,16
0,36
1,98
13,1%
Autumn
72
12,64
0,25
2,15
17,0%
56
13,12
0,24
1,83
13,9%
Note. Variation coefficient of V < 33% for all indices.
The coefficient of variation in the statistical analysis was less than 33% for all
investigation indices depending on the season which is testimony to homogeneity of
the data totality. Single – factor dispersion analysis of the seasonal influence on the
protein indices for donors of plasma for fractionation showed their variability
according to the following criteria: albumin, aggregate globulins, 1- globulins and
2- globulins in males and females, as well as – globulins in females. But the degree
of this influence was not considerably significant as a whole. The greatest degree of
this influence depending on the seasonal factor was established for 2- globulins and
– globulins in females: = 0,58 and = 0,12, accordingly.
Expressed in percentage, the index for the degree of the seasonal factor
influence on 2- globulins was 58%, on – globulins 12%, on 1- globulins 9% in
females. The greatest degree of the seasonal factor influence was 10% for 2globulins and 7% for 1- globulins in males.
The data tabulated in the table show that the content of general protein in
females was lowest in the spring, highest in the summer and autumn. The level of
albumin both in females and males was highest in spring and lower in summer.
A pronounced seasonal effect was seen in the total values for globulins: the
concentration was high in summer and low in spring. It should be marked in this case
that the seasonal redistribution of the globulin fractions is somewhat different: high
values of 1- globulins, substantiated by a dispersion analysis, were registered in the
donors of both sexes in the autumn, 2- globulins in the summer and autumn and low
23
values were in winter, – globulins in the winter, in the summer and in the spring
accordingly.
C o n c l u s i o n . Consequently, the results of the single-factor dispersion
analysis of the seasonal influence on the protein composition of the blood plasma
from the donors of this component designed for the subsequent making out of them
medical preparations revealed certain regularities. So, the content of general proteins
and its fractions was within the range of normal values. Seasonal changes were
demonstrated in following indices for the protein metabolism:
albumin, total
albumins, 1- globulins and 2- globulins both in males and females, as well as –
globulins in females. The influence of seasonal factor was greater on globulin
components, especially in female donors. The reason for a change of the indices for
proteins may be connected with peculiarities of nourishment in different seasons as
well as with the fact that women are more prone to using diet.
References
1. Russanov V.M., Levin I. Medical blood preparations.-M.: ID Medpractica,
2004-P.284.
2. Levin I, Russanov V.M. Blood service. (International analytical revue).-M.:
Medpractica, M. 2007-P.316.
3. Russian ministry of Public Health Order in № 364 of 14.09.2001 «On
ratification of procedure for medical examination of donors of blood and its
components » in the wording of the Russian ministry of Public Health and Social
Development Order from 16.04.2008, the number 175n.
Information about the authors:
Kovtunova Marina Evgenievna - candidate of medical science, scientific
secretary of the FSI «Kirov Research Institute of Hematology and Blood Transfusion
of
the
FMBA
of
Russia»,
work
tel.:
8(8332)
54-96-76.
E-mail:
mkovtunova@yandex.ru
Pozdeev Nikolai Markovich - doctor of medicine, Deputy Director of the FSI
«Kirov Research Institute of Hematology and Blood Transfusion of the FMBA of
Russia», work tel.: 8(8332) 37-68-95. E-mail: np@vit.ru
24
Kashin Konstantin Pavlovich - part-time postgraduate FSI «Kirov Research
Institute of Hematology and Blood Transfusion of the FMBA of Russia»,
transfusiologists, phone: 8(961)568-17-61. E-mail: para_celsus@mail.ru
Kunof Viktor Konstantinovich - medical director of blood transfusion centre,
work tel.: 8(833) 54-25-27.
M a t e r i a l R e c e i v e d 22.03.2010 г.
1285 Нехорошев+
UDC 613.6:616.31
© A.S. Nekhoroshev, N.B. Danilova, E.I. Morozova, 2010
Nekhoroshev A.S.1, Danilova, N.B.2, Morozova E.I.2 Methodological aspects of
the use of training programs on hygiene of oral cavity physician-stomatologists
practitioners // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
1
Saint-Petersburg state medical academy named after I.I. Mechnicov, Russia,
195067, Saint-Petersburg, Piskariovskiy av., 47. Tel.: 8(812)545-13-39, fax:
8(812)545-13-39. E-mail: mechnik@gmail.com
2
State Educational Establishment for Additional Professional Training «Saint-
Petersburg Medical Academy for Post-Diploma Training of the Federal Agency for
Public Health and Social Development of the Russian Federation», Russia, 191015,
Kirochnaya str., 41, tel.:8(812) 272-52-06, fax: 8(812)273-00-39, e-mail:
admin@maps.spb.ru
S u m m a r y : Improvement of a condition of stomatologic health of children
and adults is impossible without medical education, training and development of
skills and the manipulations connected with personal hygiene of an oral cavity. It
once again underlines importance of introduction of programs of training to hygiene
of an oral cavity in various treatment-and-prophylactic establishments of a
stomatologic profile of our country for all age groups of the population.
Key
w o r d s : doctor the stomatologist; oral cavity; training programs;
medical education.
25
References
1. Багдасарова О.А. Выбор рациональной системы профилактики кариеса
зубов у детей школьного возраста / О.А. Багдасарова // Автореф…дис. канд.
мед. наук. – Самара, 2009. – 22 с.
2. Киселева Е.Г. Взаимоотношения врачей и пациентов на детском
стоматологическом приеме и пути их улучшения / Е.Г. Киселева, Д.А.
Кузьмина. – СПб.: ООО «МЕДИ издательство», 2006. – 48 с.
3. Кобиясова И.В. Практика и теория грамотного общения с пациентом /
И.В. Кобиясова, М.А. Соболева // Профилактика сегодня. – 2009.- № 9. – С. 1420.
4. Приказ Министерства здравоохранения и социального развития РФ от
14 апреля 2006 г. № 289 «О мерах по дальнейшему совершенствованию
стоматологической помощи детям в Российской Федерации». Приложение №8
«Рекомендуемые штатные нормативы медицинского и другого персонала
детской стоматологической поликлиники».
5. СанПиН 1.2.676-97 «Гигиенические требования к производству,
качеству и безопасности средств гигиены полости рта». Утвержденные
Постановлением
(с
изм.,
внесенными
постановлениями
Главного
государственного врача РФ от 20.10.1997 №24) (с изм. от 10.12.2002) (вместе с
«Руководством по косметической продукции, утвержденной ЕЭС» (инструкция
76/768/ЕЭС)).
6. Улитовский С.Б. Практическая гигиена полости рта / С.Б. Улитовский.
– М., 2002. – С. 328.
Information about the authors:
Nekhoroshev A.S. - doctor of medicine, professor, department of preventive
medicine Saint-Petersburg state medical academy named after I.I. Mechnicov. Tel.:
8(812)545-13-39, fax: 8(812)545-13-39, e-mail: nekhoroshev@list.ru
Danilova Natalia Borisovna the candidate of medical sciences, first category
physician the doctor of the first category, the assistant to chair of therapeutic
stomatology of. Saint-Petersburg Medical Academy for Post-Diploma Training of the
26
Federal Agency for Public Health and Social Development of the Russian Federation.
Russia, 191015, St.-Petersburg, Kirochnaya str., 41. Тel.: 8(812)532-08-80. E-mail:
admin@maps.spb.ru
Morozova Elena Ivanovna - the doctor of the first category physician, assistant
professor of therapeutic stomatology department of Sankt. The Petersburg medical
academy for Post-Diploma Training of the Federal Agency for Public Health and
Social Development of the Russian Federation. Russia, 191015, St.-Petersburg,
Kirochnaya str., 41. Тel.: 8(812)532-08-80. E-mail: admin@maps.spb.ru
M a t e r i a l R e c e i v e d 09.02.2010 г.
1324 Наврузов+
UDC 591.1+612.669+631.17+614.7
© E.B. Navruzov, 2010
Navruzov E.B. Reproductive system hormones content in rats at the hossipole
intoxication // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
Tаshkent Medical Aсademy, Ministry of Health of the Republic of Uzbekistan,
100109, Uzbekistan, Tаshkent, Faroby str., 2, Tel: +998 (71) 1507825, 2148311; Fax:
+998 (71) 2185948, E-mail: info@tma.uz; tta2005@mail.ru
S u m m a r y : The variability of honadotrope and sex hormones under the
influence of acute intoxication by hossipole revealed the presence of dose-effect
dependence in the experimental groups of male and female white vats. The
disturbances of honadotrope hormons secretion appear secondary in the response to
sharp change of hormonal function, which allows to consider the affection of honads
leading on the hossipole intoxication.
K e y w o r d s : hossipole; reproductive function; steroidic and honadotropic
hormones.
References
1. Байкулов
А.А.
Токсикологичская
оценка
хлопкового
масла
/
А.А. Байкулов, А.С. Худайберганов // Токсикологический вестник. – 2001. № 2. - С. 21-23.
27
2. Байкулов А.А. Медико-биологическое обоснование гигиенических
критериев пищевой, биологической ценности и безопасности хлопкового масла,
получаемого при различных технологических режимах / А.А. Байкулов //
Автореф…дис. канд. мед. наук. – Ташкент, 2003. – 20 с.
3. Вильям М.Кэттайл Патфизиология эндокринной системы / М.Кэттайл
Вильям, А.Арки. Рональд. - СПб., 2001. – 336 с.
4. Гистология, цитология, эмбриология. Атлас: Учебное пособие /
О.В. Волкова [и др.] – М.: Медицина, 1996. – С. 398-453.
5. Душкин В.А. Лабораторное животноводство / В.А. Душкин. – М., 1980.
– 48 с.
6. Карпенко
Н.А.
Влияние
тестостерона
и
его
метаболита
дегидротестстерона на уровень некоторых гормонов у гипотиреоидных крыс /
Н.А. Карпенко // Проблемы эндокринологии. - 1991.- Т. 31., № 6. - С. 40-43.
7. Меньшикова В.В. Лабораторные методы исследования в клинике.
Справочник / В.В. Меньшикова.- М.: Медицина, 1987. – 368 с.
8. Майкл Т. Мак Дермотт. Секреты эндокринологии / Мак Дермотт
Майкл Т. пер. с англ. - М.- СПб.: Издательство Бином – невский диалект., 2001.
- С. 309-379.
9. Серов
В.П.
Практическое
руководство
по
гинекологической
эндокринологии / В.П. Серов, В.Н. Прилепская, Т.Я. Пшеничникова. - М., 1995.
– 286 с.
10. Соатов Т.С. Изменения в содержании гормонов и липидных
комплексов в крови у мужчин с нарушениями половой и тиереидной функций /
Т.С. Соатов,
М.К. Мансурова,
Д. Алиева
//
Журнал
теоретической
и
клинической медицины. - 1999. - № 1. - С. 89-91.
Information about the author:
Navruzov Ernazar Botirovich – jr. scientific assistant of the scientific research
sector of Tashkent Medical Academy, work phone: 8(833)150-78-24.
M a t e r i a l R e c e i v e d 21.05.2010 г.
28
1325 Усманова+
UDC 614.2.07:614.211:616.31-022:616.327.2-022:616.5-022
© Sh.F. Usmanova, 2010
Usmanova Sh.F. Microenvironmental problems of medical nurses in clinical
subdivisions // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
Тashkent Medical Academy, Ministry of Health of the Republic of Uzbekistan,
Republic of Uzbekistan, Tashkent, 100109, Faroby str., 2, Tеl.: +998(71)150-78-25,
214-83-11, 150-78-01 Fax: +998(71)150-78-28. Web: www. tma.uz E-mail: info@
tma.uz; tta2005@mail.ru; tma_2005@mail.ru
S u m m a r y : An expressed dysbiosis of microflora which characteristic
feature is reduction of anaerobic group and growth of facultative flora was
established on skin, nasopharynx, oral cavity of medical nurses in the aging groups
from 29 to 39 engaging in different clinical subdivisions. Microflora dysbiosis
requires correction.
Key
w o r d s : Medical nurses; microflora of skin, nasopharynx, oral
cavity; microflora dysbiosis.
References
1. Венцел Р.П. Внутрибольничные инфекции / Р.П. Венцел. - М.:
«Медицина», 1990. – 656 с.
2. Грачева Н.М. Дисбактериозы кишечника: причины возникновения,
диагностика,
применение
бактериальных
биологических
препаратов
/
Н.М. Грачева, Н.Д. Ющук, Р.П. Чупрынина. - М., 1999. – 41 с.
3. Смолянская А.З. Современные аспекты дисбактериоза кишечника и его
бактериологическая диагностика / А.З. Смолянская, Г.И. Гончарова, Н.Н. Лизко
// Лабораторное дело. – 1994. - № 3. - С. 167-170.
Information about the author:
Usmanova Shahnoza Faruhtdinovna – aspirant of department of Social Health
& Organization and Management of Health Science of the Tashkent Medical
Academy; office phone: +998(71)150-78-04; E-mail: valentinа-kim@mail.ru
M a t e r i a l R e c e i v e d 24.05.2010 г.
29
NEW TECHNOLOGIES, METHODS OF DIAGNOSTICS,
TREATMENT AND PREVENTION IN PUBLIC HEALTH
SERVICES
1213 Гонтарь+
UDC 616.72-002.77-08+616.5-004.1-08+616.5-002.252.2-08
© I.P. Gontar, N.V. Nenasheva, N.A. Matasova, E.R. Avetisova, L.I. Kochneva,
I.A. Zborovskaya, 2010
Gontar I.P., Nenasheva N.V., Matasova N.A., Avetisova E.R., Kochneva L.I.,
Zborovskaya I.A. Clinical-diagnostic value of determination of antibodies to elastin
and elastase in patients with rheumatic arthritis, systemic lupus erythematosus,
systemic scleroderma // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
State
Institution
Research
Institute
for
Clinical
and
Experimental
Rheumatology of the Russian Academy of Medical Sciences, 400138, Volgograd,
Zemlyachki str., 76, tel.: 8-8442-35-56-48, fax: 8-8442-93-42-11, e-mail:
rheuma@link.ru
S u m m a r y : Article describes the building of anti-elastin and anti-elastase
antibodies by patients with connective tissue diseases, demonstrates a correlation
between their level and development of illness.
Key
words:
rheumatoid arthritis, systemic lupus erythematosus,
scleroderma, elastin and elastase antibodies, diagnostic importance.
References
1. Гонтарь И.П. Иммобилизированные гранулированные антигенные
препараты с магнитными свойствами в диагностике и лечении ревматоидного
артрита, системной красной волчанки и системной склеродермии (клиникоэкспериментальное исследование) // Автореф. дисс….док.м.н. – Волгоград. –
2006. – 34 с.
2. Colburn K.K. Serum anti-tropo:anti-elastin antibody ratio assessing elastin
tumover in scleroderma / K.K. Colburn, G.T. Kelly, M.C. Malto // Clin Rheumatol. –
1992. - Vol. 11. - № 2. – Р. 206-210.
30
3. Colburn K.K. Abnormalities of serum antielastin antibodies in connective
tissue diseases / K.K. Colburn, E. Langga-Shariffi, G.T. Kelly // J Investig Med. –
2003. - Vol. 51. - № 2. – Р. 104-109.
4. Dunphy J. Antineutrophil cytoplasmic antibodies and HLA class II alleles in
minocycline-induced lupus-like syndrome / J. Dunphy, M. Oliver, A.L. Rands // Br.
J. Dermatol. – 2000. - Vol. 142. - № 3. – Р. 461-467.
5. Gminski J. Anti-elastin antibodies in systemic lupus erythematosus /
J. Gminski, W. Poborski, A. Kasprzak // Pol Tyg Lek. – 1990. - Vol. 45. - № 25-26. –
Р. 513-515.
Information about the authors:
M a t e r i a l R e c e i v e d 12.10.2009 г.
1311 Орлов+
UDC 616.833-006-07
© A.Yu. Orlov, G.S. Kokin, R.G. Daminov, D.Yu. Komkov,
K.Sh. Berishvili, 2010
Orlov A.Yu., Kokin G. S., Daminov R. G., Komkov D.Yu., Berishvili K.Sh.
Methods of examination of patients with peripheral nerve tumors // Preventive and
clinical medicine. – 2010. - № 2 (35). – Р.
Russian Polenov Neurosurgial Institute. Russia, 191014, St-Petersburg,
Mayakovsky str., 12, tel./fax: 8 (812) 275-56-03, e-mail: iakovenko@rambler.ru
S u m m a r y : This work was made in Russian Polenov Neurosurgial
Institute. It’s based on inspection and treatment of 284 patients with tumours of
peripheral nervous system. During this work, the complex of research of that pations
has been developed. It included clinical inspection? Electrophysiological, ultrasonic,
MRT. There were shown positire and negative sides and expediency of carryng out
of these researches at pations with tumours of peripheral nervous system before the
operative treatment.
K e y w o r d s : tumor of a peripheral nerve; nerve; inspection of patients.
31
According to the literature, only 50% patients with tumors of peripheral nerve
trunks of extremities had correct preoperative diagnosis. In this connection correct
and full diagnostics of this pathology is very important for clinical physicians. In the
literature, despite of variety of diagnostics methods, the complex of examination for
patients with peripheral nerve tumors (PNT) of extremities is not so clear.
Research
o b j e c t i v e : to analyze advantages and disadvantages of
various methods used for examination of patients with peripheral nerve tumors and to
offer an optimum complex of examination of patients with this pathology.
M a t e r i a l s a n d m e t h o d s : The complex of examination of patients
with this pathology offered by RNHI named after professor A.L.Polenov, is based on
comprehensive examination and treatment of 284 patients with PNT of extremities
and includes: clinical-neurological, electrophysiological examination (electric
diagnostics, electromyography), ultrasonic examination (USE), magnetic resonant
imaging (MRI).
R e s e a r c h r e s u l t s a n d d i s c u s s i o n : The clinical-neurologic
examination included careful history taking, paying attention to the fact of
occurrence of pain symptoms, moment of origin of the space-occupying process
feeling (palpation), difference which occurred between these two facts. Visual
examination and palpation of patients in order to identify this localized pain, sense of
new growth, its mobility, displaceability to the poles and palpatory determination of
the limits of the tumor and its consistence, Tinel’s sign [2,3,7].
In order to determine a degree of disorder of conductivity of nerve trunks
affected by the tumor, we have used: classic electric diagnostics, study of "intensityduration" curve, electromyography, stimulation electromyography, diaphoresis
assessment, in order to determine the local blood flow, wee have determined skin
temperature, tachooscilography and reactive hyperemia.
Nowadays the following methods - diaphoresis assessment, local blood flow
assessment, determination of skin temperature, tachooscilography, reactive
hyperemia are not in use at the branch due to significant labor input, out-of-date
equipment, insufficient informativity and ambiguous interpretation of the results.
32
The methods of classical electric diagnostics used before an advent of
electromyography and radiodiagnostics methods, was aimed at identification of
changes of nerve conductivity threshold – both quantitative changes or (partial, full)
reaction of muscles regeneration. Determination of muscles denervation is based on
determination of axon excitability, i.e. the minimal degree of muscle activation at
impulse current supply. The control of minimal muscle activation was carried out
visually, the current was supplied to the motor point of the muscle. The minimum
current intensity at maximum duration (300 msec). Now an estimation of "current
intensity -duration" is carried out less often for some reasons [1,2,9]:
1.
The method is based on subjective criterion of muscle activation (visual);
2.
Significant labor input of the research;
3.
Ambiguous interpretation of the results, because at partial preservation of not
affected nervous fibers in the nerve the "current intense-duration" curve will be a
sum of excitability of affected and not-affected fibers;
4.
Sufficient persistence of changes of the curve at an estimation of reinnervation in
comparison with needle EMG;
5.
There are no modern devices for carrying out of the examination. Previously
used device UEI-1 is thoroughly off-market and obsolescent, the process of its
manufacturing was stopped more than 15 years ago;
6.
Classical electric diagnostics helps to estimate an excitability of only lowthreshold, low-myelinated fibers. In view of the fact, that axons of the highly
myelinated fibers are affected at loss of connection with neuron body earlier than
axons of non-myelinated (low-threshold) fibers [3], we can say, that the method
of estimation of M-response parameters is more sensitive, than classical electric
diagnostics.
Electroneuromyography (ENMG) is a method of registration and examination of
bioelectric activity of a muscle at rest and at self-produced tension. In the broad sense
of the word, the term electromyography includes all kinds of myography techniques
(global ENMG, needle ENMG and stimulation techniques).
ENMG together with clinical data helps to solve many diagnostic problems:
33
1. Detection of the defect
2. Determination of degree of affection of the disturbed functions (full or partial
conductivity trouble)
3. Determination of stages and nature of pathological process (denervation,
reinnervation)
Superficial (global, epicutaneous or total EMG) is a method of registration and
study of biopotentials of muscles at rest and at self-produced tension by detection of
bioelectric activity with the help of superficial electrodes from skin surface above the
motor point. This method is non-invasive and painless, it helps to estimate electric
activity of muscles globally, i.e. totally.
Needle (or local EMG) is a method of registration and studying of bioelectric
activity of motor fibers and motor muscle units by needle electrodes at rest and at selfproduced tension. This method is invasive and painful, but it helps to identify the
mechanisms of work of the nervous and muscular system, which can be not identified
correctly by superficial EMG.
EMG stimulation is a method of registration and studying of bioelectric activity of
the muscles caused by activation of a nerve at any place or by activation of the
receptors of neurons by electric or mechanical stimulus. Registration of evoked (by
stimulation) activity of the muscle is carried out either by epicutaneous or needle
electrodes depending on the research problem, muscle depth and on the necessities to
exclude an activity of induction from adjacent muscles [5].
An important disadvantage of the electrophysiological diagnostics methods
(electric diagnostics and ENMG) - there is no opportunity to characterize and visualize
relative positions of space occupying lesion, nerve trunk and surrounding tissues that is
important for making a decision about surgical treatment.
Using ultrasonic examination (USE) and magnetic resonance imaging (MRI) we
can visualize the tumor, and to establish relative positions with nerve trunk and
surrounding tissues.
Ultrasonic examination is widespread method of diagnostics, it helps to visualize
a space occupying lesion and to study the topographic anatomy relations of the tumor
34
and surrounding tissues.
Use of modern ultrasonic scanners with high-frequency sensors with frequency 717 MHz helps to get an image of nerve trunks and tumors quickly without any invasion.
During the scanning process it is necessary to estimate an anatomic integrity of the
nerve trunk, its structure, clearness of the contours of the tumor, nerve and condition of
surrounding tissues [4,12].
An ultrasonic image of nerve trunk tumor is typically anechoic mass with not
always homogeneous echogenicity. Taking into account the features of tumor anatomy
and its location inside of the nerve trunk, the tumor will have round or oval shape with
even contours and clear borders. Sometimes it is possible to see spindle shape with
distribution of the along the nerve trunk. Use of color duplex mapping mode helps to
identify the presence of own tumor vessels and to determine relative positions of the
affected nerve with adjacent main vessels. If echoscopy results show unclear borders of
the tumor, an invasive relative position to surrounding tissues and vessels, we can say
that it is malignant tumor [4,12].
Except for simplicity of use, cheapness and availability the ultrasonic method
of diagnostics has one more very important advantage - an opportunity of its use during
the operation. So, in case of rather small dimensions of the tumor and rather poor
differentiation along the nerve we can carry out contact ultrasonic examination. As a
result, the surgeon can identify the borders of the tumor along the nerve more precisely.
We have used the intraoperation ultrasonic navigation method many times.
Disadvantages of the method are: visualization of not affected nerve trunks is
complicated, i.e. it is hard to identify the nerve in the muscular tissues of the healthy
extremity. For its more precise visualization it is necessary to use sensors with higher
frequency of radiation. However, proceeding from the physics of the method, the higher
is the radiation frequency, the lower is the penetrating ability of the ultrasonic beam
into the tissues.
Thus, the high-quality image can be obtained only for superficial objects or for quite
large objects.
35
Magnetic resonance imaging (MRI) has many advantages compared to other
examination methods, such as an opportunity of multiplane research, absence of
ionizing radiation, absence of artifacts from bone structures. With the help of modern
MRI devices and special software it is possible to get information not only about the
tissues surrounding the tumor, but also about nerve structures.
MRI [6] helps to estimate anatomic and topographic ratios of nerve trunks, large
vessels and surrounding tissues, to solve the problems of differential diagnostics,
including, detection of space occupying lesion and to offer histological structure of
the tumor.
Using MRI we can determine a location of the mass, its influence on a nerve
trunk, its extent, to compare the pathologically changed sites with opposite intact
sites. In practice it is very convenient to use software with fat signal suppression in
order to improve the quality of visualization [8,10,11].
MRI of peripheral nerves alongside with the results of clinical-neurological and
electrophysiological methods of examination helps to make the diagnosis more
specific, to find indications and contra-indications for surgical treatment, to select the
optimum access and volume of surgical intervention.
Conclusion:
In order to make a right diagnosis and define the
indications, treatment tactics in patients with peripheral nerve tumors at preoperation
stage, it is necessary to carry out the flowing actions:
1. Clinical and neurological examination.
2. Electroneuromyography
3. Ultrasonic examination.
4. Magnetic resonance tomography.
References
1. Bersnev V.P. Classic electric diagnostics and determination of "intensity duration" curve at nerve injuries // Guidelines. - L., 1974. - 23 pages.
2. Grigorovich K. A. About diagnostics and surgical treatment of spinal nerves
neurinomas // Surgery theory and practice. - Proceedings of LSGMI. - Т. 57. - L.,
I960. Pages 308-319.
36
3. Grigorovich К.А. Surgical nerve injuries. - L., "Medicine". - 1981. – 302
pages.
4. Eskin N.A., Golubev V.G., Bogdashevskij D.R. et al. Echography of nerves,
tendons and ligaments // SonoAce International. 2005. Issue 13. Pages 82-94.
5. Komantsev V.N., Zabolotnykh V.A. Methodical bases of clinical
electroneuromyography – doctor’s manual / Komantsev V.N., Zabolotnykh V.A.Saint Petersburg, 2001. _ 349 pages.
6. Konovalov A.N. Magnetic resonance tomography in neurosurgery /
A.N.Konovalov, V.N, Kornienko, I.N. Pronin. - M.: Vidar, 1997. - 472 pages.
7. Popeljanskij J. J. Diseases of peripheral nervous system. / J.J. Popeljanskij. M.: Medicine, 1989.-275 pages.
8. Abernathy CD, Onofrio BM, Scheithauer BW, Pairolero PC, Shives TC.
Surgical management of giant sacral schwannomas. J Neurosurg 1986; 65:286-95.
9. Altenburger К. Electrodiagnostik // Bumke О., Foerster О. Handbuch der
neurologie. 1937.-747.
10. Elston DM, Bergfeld WF, Biscotti CV, McMahon JT.Schwannoma with
sweat duct differentiation. J Cutan Pathol 1993; 20:254-8.
11. Peer S., Bodner G. High-Resolution Sonography of the Peripheral Nervous
System // 2003. Springer. 140 p.
Information about the authors:
Orlov A.J. - candidat of medical sciences Russian Polenov Neurosurgial
Institute, tel.: 8(921)910-40-06, e-mail: orloff-andrei@mail.ru
Kokin G.S. - candidat of medical sciences, post-graduate student Russian
Polenov Neurosurgial Institute, tel.: 8(812)272-26-03.
Daminov R.G- physician-neurologist, post-graduate student Russian Polenov
Neurosurgial Institute. tel.: 8(812)272-26-03.
Komkov D.J. - candidat of medical sciences, post-graduate student Russian
Polenov Neurosurgial Institute, tel.: 272-26-03.
Berishvili K.S. - physician-neurologist, post-graduate student Russian Polenov
Neurosurgial Institute. tel.: 8(812)272-26-03.
37
M a t e r i a l R e c e i v e d 13.04.2010 г.
1278 Гренкова+
UDC 618.146/.17-07
© Yu.M. Grenkova, M.M. Safronova, 2010
Grenkova Yu.M., Safronova M.M. Modern approaches to diagnostics of uterine
cervix diseases in post menopause // Preventive and clinical medicine. – 2010. - № 2
(35). – Р.
State Educational Establishment for Additional Professional Training «SaintPetersburg Medical Academy for Post-Diploma Training of the Federal Agency for
Public Health and Social Development of the Russian Federation», Russia, 191015,
Kirochnaya
str.,41,
tel.:8(812)
272-52-06,
fax:
8(812)273-00-39,
e-mail:
admin@maps.spb.ru
S u m m a r y : This study was dew to ultrasonic examination cervix uteri in
postmenopausal women. Our data indicated different types of ultrasonic images of
cervix due to duration of post menopause. The study involved 91 postmenopausal
women, among them 59,3% of cases diagnosed endocervicitis. Were identified
ultrasound signs endocervicitis in postmenopausal women.
Key
words:
endocervicitis;
postmenopausal;
ultrasonography;
ultrasound examination.
In recent years in Russia, a steady increase in number of infectiousinflammatory diseases of the vagina and the cervix of the uterus has occurred, 73,2 %
of them involving endocervicitis [1]. Within 10 years following cessation of
menstruations, the “postmenopause atrophic vaginitis” occurs in 75% of the women
[2]. In the postmenopause, no tendency towards any decrease in the cervix of the
uterus (CU) inflammatory diseases can be observed in spite of reduction in the sex
activity which might be due to presence of inflammatory diseases in the past, to the
process becoming chronic, to errors in the diagnostics and therapy [3].
The clinical picture of inflammatory diseases of the genitals lower segments in
the postmenopause women reveals a number of specific features due to age-specific
38
changes in the genitals’ mucous membrane. In association with the ovaries function
fall-out, the blood supply becomes rather worse, elasticity of the sex organs’ mucous
membrane becomes reduced, the rhythm of epithelium desquamation disappears,
production of mucus sharply drops due to metaplasia and changes in the cylindrical
epithelium structure, the vaginal microbiocenosis becomes disturbed, and the
physiological protection of the vaginal epithelium and endocervix becomes much
lower. These factors provide for appearance of favourable conditions for exogenous
opportunistic pathogenic bacteria and for activation of the endogenous those. The
reduction of the protection factors in the postmenopause prompts the persistence of
infection.
Diagnostics of the cervix of the uterus chronic inflammatory diseases,
particularly of the cervical canal, is quite complicated. In fact, the existing
endocervicitis is due to penetration of microorganisms to the intercellular space of the
mucous membrane crypts against the background of occurring metaplasia which
makes the infectious factor less accessible for diagnostics and sanitation [3].
The main techniques of assessment of the cervix of the uterus condition
involve visual examination with the aid of gynaecological mirror and colposcope, as
well as microbiological and oncocytological study of the material obtained from ectoand endocervix. Also assessment of junction of different types of the epithelium,
revealing of the background pathological condition (inflammation, dyskeratosis), and
diagnostics of cervical intraepithelial dysplasia are important. A screening technique
for revealing CU cancer involves oncocytological study. To verify the pathogenic
agent in inflammation, bacterioscopic, bacteriological and molecular-biological
techniques are used.
The cervical canal relates to the so called “mute” zone of diagnostics because
of practical inaccessibility for its study in its upper 2/3. The assessment of the
cervical canal condition is made more difficult by obliterating processes associated
with some past inflammation, or diathermic-surgical methods of treatment, or agespecific changes. Diagnostic curettage of the cervical canal relates to invasive method
often quite difficult to perform and insufficiently informative by many positions. A
39
highly informative and non-invasive method involves ultrasonic study of the small
pelvis organs that is included in the algorithm of gynaecological examination of the
patients. In this connection, the improvement of the radial diagnostics of the uterus is
quite promising for revealing pathological conditions of the CU and, particularly, the
endocervix.
Objective
of
the
w o r k . More precise definition of diagnostic
capacities of the echography for assessing the condition of the cervix of the uterus in
patients with cervicitis in postmenopause.
M a t e r i a l s a n d m e t h o d s o f t h e s t u d y . 91 women aged
45 to 79 were studied, the women having had the menopause for the last 1 to 25
years. The patients presented complaints of discomfort in the genitals area: itching,
burning, pain in the vagina, unpleasant sensations in urination, smearing sanguinolent
discharges from the reproductive tracts, dyspareunia.
We related the patients to the endocervicitis verification risk group if their
examination with the aid of gynaecological mirror and colposcope revealed signs as
follows: hyperaemia around the external orifice of the cervix of the uterus, contact
haemophilic manifestations from the cervix of the uterus, mucin-purulent discharges
from the cervical canal, the picture of “diffuse” and/or “focal” colpitis in colposcopy.
In bacteriological study, the amount of polymorphous-nuclear leucocytes over 10 was
taken into consideration at magnification х 1000 and examining of at least 5 fields of
vision, as well as finding of trichomonades, gonococcus. In bacteriological study –
discharge of pathogenic microorganisms; opportunistic pathogenic microorganisms in
amount of the titre >10х4CFU/ml. In molecular-biological techniques – revealing of
absolute pathogenic microorganisms (Mycoplasma genitalium, C. trachomatis,
T.vaginalis, N.gonorrhoeae) [4]. In cytological study of the smears taken from the
cervix of the uterus in endocervicitis, “mixed” or “atrophic” type of the smear can be
seen (often in the postmenopause duration over 5 years) against the background of
large number of leucocytes [5].
In the course of the laboratory studies, in 54 (59,34%) of the 91 patients,
clinical-laboratory manifestations of endocervicitis were found. Past history of
40
82,14% women revealed past inflammatory diseases of the genitals lower segments
which suggested chronic proceeding of the infection due to low-quality diagnostics
and therapy in the past (p<0,01). In the past, the trichomonade infection was mostly
diagnosed: 35,29% (p<0,01), which is indirectly corroborated by persistent
complaints of dysuria (19,61%) and repeated treatment of the so called “cystitis” in
previous years.
All the patients were subjected to a complex gynaecological examination with
the aid of common techniques at the base of the State Healthcare Institution “The
Municipal Outpatient Clinic № 83”, at the base of the L.O.Ott Research Institute of
Obstetrics and Gynaecology of the Russian Acad. Med. Sci. The echography was
performed with the apparatus of the expert class ALOKA-5500 (Japan). Transvaginal
ultrasonic study of the cervix of the uterus was used in its standard technique and
then complemented with the EDC.
R e s u l t s o f t h e s t u d y a n d t h e i r d i s c u s s i o n . Specific
features of the genitals lower segment’s mucous membrane in postmenopause include
gradually thinning multilayer pavement epithelium the surface of which becomes
smooth, bright and vulnerable (in traumatisation, small haemorrhages may occur). In
endocervicitis in postmenopause, the discharges in all the patients are scarce serouspurulent those. In 54,9% of cases, contact bleeding due to obvious vulnerability of
the epithelium occurred against the background of infection (p<0,01). In 70,59%,
signs of light “diffuse” and/or “focal” colpitis were observed against the background
of the epithelium age-specific changes of various grades. In study of microbiocenosis,
in 82,35% of cases a considerable increase in the number of neutrophile granulocytes
occurred against the background of absence of the lactobacilli and a large amount of
cocco-bacillary flora. In bacteriological study, in 33,33% of cases an ample growth
of E.coli was found in the titre amount over 10х4CFU/ml. In cytological study, in the
smears, the cells of the “lower” intermediate and parabasal rows with no atypia
prevailed; in 64,7% of cases, an “inflammatory” type of the smear had been found
that was often accompanied by reactive changes of the parabasal cells which
41
demanded application of differential diagnostics with a dysplastic process with the
aid of the “proliferative test” with ovestine.
Use of the transvaginal US study enabled one to investigate into
the endocervix condition, its thickness, echo-structure, surrounding stroma of the
cervical canal, and to visualize contours of the CU vaginal segment in its whole
extent. The cervix of the uterus with no pathological changes during the US study in
the postmenopause patients has the shape of cylinder, even external contours, the
same thickness of anterior and posterior walls, homogeneous structure comparable by
its echogenicity with the echogenicity of the uterus body myometrium. The CU Mecho occupies central position and is an imaging of the cervical canal and
surrounding subepithelial segments of the cervix of the uterus that are isoechogenic
to the surrounding stroma. In the EDC of the tissues adjacent to the endocervix,
singular loci of blood flow may be observed.
We have determined various types of the endocervix visualization depending
on the postmenopause duration under normal conditions. In 73,7% of the patients
with the postmenopause duration under five years, the CU M-echo was visualized in
the form of a hyperechogenic strip of thickness up to 1-2 mm, with homogeneous
structure that was a reflection of the anterior and posterior walls of the cervical canal
mucous membrane. In the patients with the postmenopause duration over five years,
in 66% of cases, the CU structure was homogeneous, the imaging of the M-echo was
absent.
In endocervicitis, irrespective of the postmenopause duration, the echography
in 100% revealed extension of the M-echo width for over 4.5 mm on account of
enlargement of the cervical canal for over 2 mm with accumulation of liquid content
in it, as well as inflammatory infiltration of the cervical canal epithelium and the
adjacent structures (р<0,01). In 47,1% of cases in endocervicitis, thickening of the
cervical canal wall was visualized in the form of a hyperechogenic strip of a 2-3-mm
width around the enlarged cervical canal of inhomogeneous structure that can be
traced in fragment. In 32,4% of cases, the hypoechogenic area of 3 to 10 mm width
around the cervical canal enlarged on account of inflammatory infiltration around the
42
unevenly thickened wall of the cervical canal, was visualised. When assessing the
data obtained, the ultrasonic study capacity in diagnostics of endocervicitis amounted
up to 82,4%, its specifics amounting up to 87%.
C o n c l u s i o n . Complex diagnostics of the cervix of the uterus condition
including modern capacities of the echography improves the diagnostics on account
of assessment of the endocervix structure thus revealing the changes specific for an
inflammatory process in the postmenopause women.
References
1. Балан В.Е. Принципы заместительной гормонотерапии урогенитальных
расстройств / В.Е. Балан // Гинекология. – 2000. - № 2(5). – С. 140-142.
2. Прилепская В.Н. Заболевания шейки матки, влагалища и вульвы /
В.Н. Прилепская. - М.: МЕДпресс, 1999 .- С. 201-213.
3. Сметник
В.П.
Руководство
по
климактерию
/
В.П. Сметник,
В.И. Кулаков. - М.: МИА, 2001. - С. 40-52.
4. Современные технологии в лечении больных с хроническими
цервицитами / Т.А. Федорова [и др.] // Российский Конгресс «Генитальные
инфекции и патология шейки матки»: тезисы. – М., 2004. – 83 с.
5. Хмельницкий О.К. Цитологическая и гистологическая диагностика
заболеваний шейки матки и тела матки / О.К. Хмельницкий. – СПб.: Сотис,
2000. - 332 с.
Information about the authors:
Grenkova Yulia Michaylovna– post graduated student of Department of
Women's Reproductive Health, SPB MAPS, work tel.: 8(812)272-21-07, e-mail:
GrenkovaJulia@yandex.ru
Safronova Margarita Michaylovna – doctor of medicine, professor, Head of the
Department of Women's Reproductive Health, SPB MAPS, work tel.: 8(812)272-2107.
M a t e r i a l R e c e i v e d 22.12.2009 г.
1276 Ибрагимов+
43
UDC 616.5+616.97
© Sh.I. Ibragimov, T.U. Abdullaev, 2010
Ibragimov Sh.I., Abdullaev T.U. HLA-antigen association with climacteric
keratoderma // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
Scientific Research Institute of Dermatology and Venerology of Health
Ministry of the Republic of Uzbekistan. Tashkent, Uzbekistan, Faroby str., 3, tel.:
8(371) 150-71-05, fax: 8(371) 214-50-68. E-mail: www. niidiv.uz
S u m m a r y : Last years great interest is marked to problem of keratoderma,
particularly to climacteric keratoderma (CK) as one more often occuring in women of
climacteric period. The aim of our study was research of antigens HLA his to
compatibility in patients with climacteric keratoderma. The results of taken
researches have shown, that be genotyping of alleles HLA-В17 in women with CK,
revealed markers of predisposition and resistance to CK.
K e y w o r d s : climacteric keratoderma; HLA; genotype.
References
1. Каламкарян А.А. Синдром Хакстхаузена климактерическая ладонноподошвенная кератодермия / А.А. Каламкарян, Е.Г.Федорова, Е.В. Бухарина //
Вестн. Дерматол. и венерологии. - 1984. - № 9. - С. 4-6.
2. Рахимова Д.А. Распределение HLA-антигенов в узбекской популяции
Ташкентской области / Д.А. Рахимова, А.Т. Исхаков, Р.М. Рузыбакиев //
Актуальные вопросы иммунологии и аллергологии. – Ташкент, 1996. - Т.8. С.149-155.
3. Хаитов Р.М. Иммуногенетика и иммунология: резистентность к
инфекциям / Р.М. Хаитов, В.М. Манько, Л.П. Алексеев. – Ташкент: Ибн-Сино,
1991. - 454 с.
4. Luca Gavalli-Sforza L. The history and geography of human genes / L. Luca
Gavalli-Sforza, P. Menozzi, A. Piazza. - USA. - 1996. – 356 р.
Information about the authors:
Ibragimov Sharof Ismailovitch - doctor of medicine, head of the Scientific
Research Institute of Dermatology and Venerology of Health Ministry of the
44
Republic of Uzbekistan. Оffice phone: 8(371) 150-71-05, mob.ph: (+99890) 370-9508, E-mail: www. niidiv.uz
Abdullaev Temurbek Ulugbekovitch – post graduate of Scientific Research
Institute of Dermatology and Venerology of Health Ministry of the Republic of
Uzbekistan. Оffice phone: 8(371) 150-71-05, mob.ph: (+9897) 101-88-77.
M a t e r i a l R e c e i v e d 16.12.2009 г.
1341 Нилова+
UDC 616.34-008.87-07:579.864
© L.Yu. Nilova, E.A. Orishak, A.G. Boitsov, 2010
Nilova L.Yu., Orishak E.A., Boitsov A.G. Regarding the problem of probiotics
usage for intestinal disbacteriosis therapy // Preventive and clinical medicine. – 2010.
- № 2 (35). – Р.
State Educational Establishment of Higher Professional Training «Mechnikov
Sankt-Petersburg State Medical Academy of the Federal Agency for Public Health
and Social Development of the Russian Federation». Russia, 195067, SaintPetersburg, K-67, Piskarevsky pr., 47. Tel.: 8(812)543-96-09, fax: 8(812)740-15-24,
tel./fax: 8(812)543-01-26. Е-mail: mechnik@gmail.com
S u m m a r y : The purpose of the research is to develop the procedure of the
individual choice of different trademarks probiotics containing lactobacteria for
therapy in intestinal disbacteriosis. The tasks of the research are to examine
adhesiveness of probiotics lactobacteria, to compare their adhesive activity to the
different epithelia type.
Samples and methods. Cells of intestinal and buccal epithelium are taken for
the adhesion. The results are registered in average quantity of bacteria number
attached to one epithelia cell. The intensity of the adhesive activity is measured in the
scale 1-5.
The results of the research state the possibility to use probiotics lactobacteria
rate of adhesion to buccal epithelial cells for understanding their rate of adhesion to
intestinal epithelium of a certain patient. The adhesion intensity depends on receptor
complementarity of lactobacteria and patient’s epithelial cells, i.e. patient-specific
45
choice of different trademarks preparations for therapy in intestinal disbacteriosis is
founded.
Key
words:
disbacteriosis; probiotics; adhesion; adhesiveness of
probiotics strains; Lactobacillus.
References
1. Адгезия лактобактерий к клеткам вагинального и буккального эпителия
/ А.Г. Бойцов, С.В. Рищук, Ю.Ю. Ильясов, Т.А. Гречанинова // Вестник
СПбГМА им. И.И. Мечникова. - 2004. - № 4(5). - С. 191-193.
2. Адгезивные
В.И. Брилис,
и
гемагглютинирующие
Т.А. Брилене,
Х.П. Ленцнер,
свойства
лактобацилл
А.А. Ленцнер
//
/
Журнал
микробиологии, эпидемиологии и иммунологии. - 1982. - № 9. - С. 75-78.
3. Стандартизация
реакции
прямой
гемагглютинации,
вызываемой
бактериями рода Lactobacillus / Е.Д. Бершадская, Н.Г. Фиш, П.П. Шевьев,
В.И. Огарков / Журнал микробиологии, эпидемиологии и иммунологии. - 1986.
- № 8. - С. 69-71.
4. Киселев С.А. Пробиотики: новый подход к механизму терапевтического
действия при лечении дисбактериоза кишечника / С.А. Киселев, Д.С. Чичерин //
Клиническое питание. - 2007. - № 1-2. С. 44.
5. Микроэкология кишечника у детей и её нарушения / П.Л. Щербаков [и
др.] // Фарматека. - 2007. - № 14 (148). - С. 28-34.
6. Savage D.C. Microorganisms associated with epithelial surfaces and stability
of the indigenous gastrointestinal microflora / D.C. Savage // Nahrung. – 1987. –
Vol. 31, № 5-6. – P. 383-95.
7. Schillinger U. In vitro adherence and other properties of lactobacilli used in
probiotic yoghurt-like products / U. Schillinge, C. Guigas, W.H. Heinrich //
International Dairy Journal. – 2005. – Vol. 15, № 12. – P. 1289-1297.
Information about the authors:
Nilova Ludmila Yurievna – Candidate of Medical Sciences, ass. professor of
the department of microbiology, virology and immunology of the SPbGMA named
after I.I. Mechnikov, tel./fax: 8(812)543-01-95, e-mail: spbgma33@online.ru
46
Orishak Elena Alexandrovna - Candidate of Medical Sciences, docent of the
department of microbiology, virology and immunology of the SPbGMA named after
I.I. Mechnikov, tel./fax: 8(812)543-01-95, e-mail: spbgma33@online.ru
Boitsov Alexey Gennadievich - doctor of medicine, professor, head of the
department of microbiology, virology and immunology of the SPbGMA named after
I.I. Mechnikov, tel./fax: 8(812)543-01-95, e-mail: spbgma33@online.ru
M a t e r i a l R e c e i v e d 29.06.2010 г.
CLINICAL AND EXPERIMENTAL STUDIES
1343 Бельков+
UDC 616.12-005.8:615.27
© A.V. Belkov, A.S. Russin, M.I. Sadique, M.G. Kolesnichenko, A.T. Burbello,
2010
Belkov A.V., Russin A.S., Sadique M.I., Kolesnichenko M.G., Burbello A.T.
Clinical prognostic value of metabolic treatment in patients with myocardial
infarction // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
State Educational Institution of Higher Professional Training «Saint-Petersburg
State Medical Academy named after I.I. Mechnicov» under Roszdrav, Russia,
195067, St. Petersburg, Piskarevsky pr., 47, tel./fax: 8(812)543-01-26, e-mail:
mechnik@gmail.com
S u m m a r y : 62 patients have been observed aged till 70 years which have
recieved an acute myocardial infarction, receiving in addition to the basic therapy of
polyene and trimetazidine , in comparison with control group, the positive value of
metabolic therapy on balance of vegetative nervous system and electric activity of a
myocardium has been revealed.
Key
w o r d s : a myocardial infarction; trimetazidine; polyene; sudden
death.
References
47
1. Мазур Н.А. Внезапная смерть // В кн. Болезни сердца и сосудов. Под
ред. Е.И.Чазова. - М.: Медицина, 1992, - С. 133-146.
2. Camm A.J. Mortality in patients after a recent myocardial infarction: a
randomized, placebo-controlled trial of azimilide using heart rate variability for risk
stratification / A.J. Camm, C.M. Pratt, P.J. Schwartz // Circulation. - 2004. Vol. 109. - P. 990-996.
3. Casolo G.C. Heart rate variability during the acute phase of myocardial
infarction / G.C. Casolo, P. Stroder, C. Signorini // Circulation. - 1992. - Vol. 85. P. 2073-2079.
4. Farrell T.G. Risk stratification for arrhythmic events in postinfarction
patients based on heart rhythm variability, ambulatory electrocardiographic variables
and the signal-averaged electrocardiogram / T.G. Farrell, Y. Bashir, T. Cripps // J.
Am. Coll. Cardiol. – 1991. – Vol. 18. - № 5. – P. 687–697.
5. Podrid P.J. Epidemiology and Stratification of Risk for Sudden Cardiac
Death / P.J. Podrid, R.J. Myerburg // Clin. Cardiol. - 2005. - Vol. 28 (Suppl. I). - P. 311.
6. Turitto G. Sudden cardiac death prediction: the signal averaged
electrocardiogram / G. Turitto, N. El-Sherif // Europace. – 2002. - Vol. (A). - P.137.
Information about the authors:
Burbello Alexandra Timofeevna – Doctor of medicine, professor, head of the
department of hospital therapy with course of clinical pharmacology. SaintPetersburg State Medical Academy, named after I.I.Mechnikov, phone: 8(812)54394-34.
Belkov Alexey Viktorovich – Fellowship at the department of Hospital therapy
Saint-Petersburg State Medical Academy, named after I.I.Mechnikov, mobile phone
8(921)945-77-21, е-mail:avbelkov@mail.ru
Russin Alexander Sergeevich – Fellowship at the department of faculty therapy
Saint-Petersburg State Medical Academy, named after I.I.Mechnikov, ph. 8(812)54317-17.
48
Kolesnichenko M G - Fellowship at the department of faculty therapy SaintPetersburg State Medical Academy, named after I.I.Mechnikov, ph. 8(812)543-1572.
Sadique Mohammad Imran- Fellowship at the department of faculty therapy
Saint-Petersburg State Medical Academy, named after I.I.Mechnikov, ph. 8(812)54315-72.
M a t e r i a l R e c e i v e d 29.06.2010 г.
1298 Горбачева+
UDC 616.12-005.4:615.27
© I.A.Gorbacheva, Yu.A.Sycheva, L.V.Slepneva, N.N.Alekseeva,
V.A. Malozemova, D.A. Popov, 2010
Gorbacheva
I.A.1, Sycheva Yu.A.1, Slepneva
Malozemova V.A. 1, Popov D.A.
1
L.V.2,
Alexeeva
N.N.2,
Antihypoxic therapy resources in ischemic heart
treatment // Preventive and clinical medicine. - 2010. - № 2 (35). – Р.
1
State educational institution of higher professional education «Saint-
Petersburg Pavlov State Medical University of the Federal Agency for Health Care
and Social Development of the Russian Federation ». Russia, 197022, St.-Petersburg,
L. Tolstoy str., 6/8. Tel.: 8(812)238-71-53, fax: 8(812)234-01-25. Е-mail:
feedback@spbmedu.ru
2
Federal State Institution «Russian Research Institute of Hematology and
Transfusiology of the Federal Agency for Advanced Technology Medical Aid».
Russia, 191024, St.-Petersburg, 2-th Sovetskaya str., 16. Tel.: 8(812)274-56-50, fax:
8(812)717-25-50.
Summary:
Noticeable interest in usage of antihypoxants with
cytoprotective and antioxidative effects for augmentation of oxygen utilization by
myocardial tissue is seen in the last time. A new medicinal form of an antioxidant
natrium fumarate, medication «Confumine», is perspective. This study medication
has demonstrated antiarrythmic effect and positive inotropic effect in the experiment
with post hemorrhagic ischemia and coronary heart infarction. All this determines
49
necessity of Confumine usage investigation in the patients with chronic forms of
ischemic heart disease.
Key
w o r d s : antihypoxants; medication Confumine; chronic forms of
ischemic heart disease.
Information about the authors:
Gorbacheva I. A. - doctor of medicine, head of the stomatologycal department
of internal diseases Saint-Petersburg Pavlov State Medical University, tel. 8(911)33438-99.
Sycheva Yu. A. - candidate of medical science, assistant at the stomatologycal
department of internal diseases Saint-Petersburg Pavlov State Medical University, tel.
8(921)647-62-16.
Slepneva L V. - candidate of medical science, the leading scientific employee,
Russian Research Institute of Hematology and Transfusiology, tel. 8(812)717-10-80.
Alekseeva N N. - candidate of biological science, the leading scientific
employee, Russian Research Institute of Hematology and Transfusiology, tel.
8(812)717-10-80.
Malozemova V.A. - assistant at the stomatologycal department of internal
diseases Saint-Petersburg Pavlov State Medical University, tel. 8(911)220-24-95.
Popov D.A. - the clinical intern of the stomatologycal department of internal
diseases Saint-Petersburg Pavlov State Medical University, tel. 8(950)014-24-54.
M a t e r i a l R e c e i v e d 15.03.2010 г.
1299 Ливанов+
UDC 616.12-005.8:616-008.9
© G.A. Livanov, V.P. Amagyrov, B.V. Batotsyrenov, A.N. Lodyagin,
H.V. Batotsyrenova., 2010
Livanov
G.A.,
Amagyrov
V.P.,
Batotsyrenov
B.V.,
Lodyagin
A.N.,
Batotsyrenova H.V. Metabolic distress correction in complicated forms of myocardial
infarction // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
1
I.I. Dzanilidze First Aid Research Institute, Russia, 192242, St.-Petersburg,
Budapeshtskaya str., 3.
50
2
Municipal health care institution «The State clinical first medical aid hospital
named after Agapov V.V.», Russia, 670042, Republic of Buryatiya, Ulan-Ude,
Stroiteley prospect, 1.
S u m m a r y : It has been resulted the evaluation of clinical finding in 36
patients with acute myocardial infarction, complicated by acute heart failure (AHF)
II-IV difficulty classes by Killip Т., Kimball J. (1967). Cytoflavin and perftoran
promoted a decrease of patient’s critical situation length, patient’s day number and
lethality. It was established that using of these drugs decreased tissues hypoxia depth,
lipid peroxidation and restored antioxidant system activity and oxygen utilization.
K e y w o r d s : acute myocardial infarction; acute heart failure; perftoran;
cytoflavin; antioxidant system; oxygen utilization.
References
1. Бойцов С.А. Клиническое изучение противоишемического препарата
Мексикор у больных с неосложненными формами инфаркта миокарда с зубцом
Q / С.А. Бойцов, А.А. Фролов, В.Ю. Полумисков // Клин. исследования
лекарственных средств в России. - 2004. – № 2. – С. 28-32.
2. Метаболическая десинхронизация при критических состояниях /
Г.А. Ливанов [и др.] // Общая реаниматология. - 2006. – № 1. – С. 42-46.
3. Руда М.Я. О системе лечения больных с острым коронарным
синдромом / М.Я. Руда // Кардиологический вестник. - 2006. – Т. 1, № 2. – С. 36.
4. Рябов Г.А. Гипоксия критических состояний / Г.А. Рябов. – М.:
Медицина, 1988. – 287 с.
5. Семиголовский Н.Ю. Применение антигипоксантов в остром периоде
инфаркта миокарда / Н.Ю. Семиголовский // Анестезиология и реаниматология.
- 1998. – № 2. - С. 56-59.
6. Сравнительная динамика маркеров воспаления и NT-proBNP при
различных вариантах лечения больных с острым коронарным синдромом /
Шрейдер Е.В. [и др.] // Кардиология. - 2008. - № 8. – С. 20-27.
51
7. Abbate A. C-reactive protein and other inflammatory biomarkers as
predictors of outcome following acute coronary syndromes / A. Abbate, G.G. BiondiZoccai, S. Brugaletta // Semin Vasc Med. – 2003. - № 3. – Р. 375-384.
8. Antman E.M. ACC/AHA guidelines for the management of patients with STelevation
myocardial
infarction:
a
report
of
the
American
College
of
Cardiology/American Heart Association Task Force on Practice Guidelines
(Committee to Revise the 1999 Guidelines for the Management of Patients With
Acute
Myocardial
Infarction)
/
E.M. Antman
//
2004
–
www.acc.org/
clinical/guidelines/stemi/index.
9. Biasucci L.M. Inflammation, atherosclerosis and acute coronary syndromes /
L.M. Biasucci, M. Santamaria, G. Liuzzo // Minerva Cardioangiol. – 2002. – Vol. 50,
№ 5. – Р. 475-486.
10. Mold C. Complement activation by apoptotic endothelial cells following
hypoxia/reoxygenation / C. Mold, C.A. Morris // Immunology. - 2001. – Vol. 102,
№ 3. – Р. 359-364.
Information about the authors:
M a t e r i a l R e c e i v e d 09.03.2010 г.
1339 Фролова+
UDC 612.821
© N.L. Frolova, 2010
Frolova N.L. Features of autonomic regulation of heart rate in cardiac patients
with psychosomatic profile // Preventive and clinical medicine. – 2010. - № 2 (35). –
P.
Federal
government
agency
«Military
Medical
Academy»
(FGA
MMA). Russia, 194044, St.-Petersburg, Academician Lebedev str., 6. Tel.:
8(812)542-20-91. E-mail: http://www.vmeda.spb.ru
Summary:
The aim of this study was to detect сardiovascular
neuroregulation and rhythms of the autonomic nervous system by cardiovascular
disease. Short-term recordings of heart rate variability distinguish two main spectral
components: a high-frequency (HF) component (ranging between 0.15-0.40 Hz), a
52
low-frequency (LF) component (ranging between 0.04-0.15 Hz), and LF/HF ratio
respectively considered markers of parasympathetic, sympathetic control and
sympatovagal balance. The changes in HF and LF powers and LF/HF ratio observed
by the free breathing, the 6 min breathing and the coordinating components of
respiration and heart rate variability series.
Key
w o r d s : heart rate variability; breathing rhythm; cardiovascular
disease.
References
1. Вариабельность
С.А. Котельников,
ритма
сердца:
представления
А.Д. Ноздрачев,
о
механизмах
М.М. Одинак,
/
Е.Б. Шустов,
И.Ю. Коваленко, В.Ю. Давыденко // Физиология человека.– 2002. – Том 28. –
№ 1. – С. 130 – 141.
2. Использование кардиореспираторного биоуправления в диагностике и
коррекции
регуляторных
нарушений
при
нейроциркуляторной
астении
/
Н.Л. Фролова, А.С. Свистов, А.Е. Филиппов, Н.Б. Суворов // Вестник Российской
Военно-медицинской академии. – 2005. – № 2 (13). – С. 243-247.
3. Heart
Rate
Variability.
Standards
of
measurements,
physiological
interpretation, and clinical use / Task Fors of the European Sosiery of Cardiology and
the North American Sosiery of Pacing and Electrophysiology // Circulation. – 1996. –
Vol. 95. – P. 1043.
4. Melcher A. Carotid baroreflex heart rate control during the active and the
assisted breathing cycle in man / A. Melcher // Acta Physiol. Scand. – 1980. –
Vol.108. – № 2. - P. 165.
5. Power spectrum analysis of heart rate fluctuation: A quantitative probe of
beat-to-beat cardiovascular control / S.D. Akselrod [et al.] // Science. – 1981. –
Vol. 213. – № 4503. – Р. 220.
6. Richter D.W. Cardiorespiratory control / D.W. Richter, K.M. Spyer //
Central regulation of automomic fluctuations. – N.Y.: Oxford Univ. – Press, 1990. –
P. 189.
Information about the author:
53
Frolova Natalia Lvovna - PhD, Cathedral Assistant of Naval and Hospital
Therapy Department. Mob.: 8(911)195-08-09. E-mail: creative_n@list.ru.
M a t e r i a l R e c e i v e d 24.06.2010 г.
1294 Козырев+
UDC 616.248+616-009.12]:577.112
©A.G. Kozyrev, E.A. Surkova, A.Yu. Gichkin, V.E. Perley, 2010
Kozyrev A.G., Surkova E.A., Gichkin A.Yu., Perley V.E. Endotelin-1 content in
patients with bronchial asthma with concomitant hypertensive disease // Preventive
and clinical medicine. – 2010. - № 2 (35). – Р.
State Educational Establishment for Higher Professional Training «SaintPetersburg State I.P. Pavlov Medical University of the Federal Agency for Public
Health and Social Development of the Russian Federation». Russia, 197022, St.Petersburg, Lev Tolstoy str. 6/8. Tel. 8(812)4997153, fax 8(812)2340897.
Summary:
Serum levels of endothelin-1 were investigated in 80
asthmatic subjects. Serum level of endothelin-1 after the treatment of asthma
exacerbation was higher in patients with concomitant essential hypertension, stage I,
than in patients with optimal and normal blood pressure.
K e y w o r d s : bronchial asthma, essential hypertension, endothelin-1
Endothelin 1 (ET-1) represents a polypeptide that has many biological effects,
and can act as an autocrine/paracrine mediator. Apart from having vasoconstrictive
function ET-1 can also be characterized with pro-inflammatory and proliferative
activity, can stimulate production of free radicals, and may activate platelets. ET-1 is
considered as one of the major components that results in endothelial dysfunction and
cardiovascular disorders [1]. It is known [9] that ET-1 has a profound effect in
pathogenesis of lung diseases, including bronchial asthma (BA). Lungs represent
tissue site where ET-1 undergoes metabolic turnover.
A i m o f s t u d y – to evaluate serum concentration of ET-1 in patients
with bronchial asthma and concomitant essential hypertension (EH).
54
Materials
and
Methods.
In our study we included 80 BA
patients who visited a pulmonologist due to exacerbation of disease. This group of
patients was composed of 21 male and 59 females, average age 54.0 ± 1.0 years old.
In 5 patients mild persistent BA (mBA) was diagnosed, in 56 – moderate BA
(moBA), in 19 – severe BA (sBA). 33 BA patients (Group I) had optimal or normal
values of blood pressure (BP). In 10 patients (Group II) high normal BP was
recorded. In 37 cases patients with BA were diagnosed to have EH, including EH
stage I in 19 cases (Group III), EH stage II – in 18 cases (Group IV). The most part of
patients from Group III and IV had EH grade 1. In control group we included 10
healthy persons (3 males and 7 females, average age 57.1 ± 1.7 years old). Prior to
starting these examinations all patients signed Informed Consent.
In our study we included outpatients who had no overt clinical signs of present
or previous complications after cardiovascular diseases (coronary heart disease,
stroke) or renal diseases; non-smokers, with normal fasting plasma glucose level.
During the first visit nine patients with BA and concomitant EH were found to take
their hypotensive medicines regularly, including angiotensin converting enzyme
inhibitor (enalapril) – 3 cases, diuretic drug (indapamide) – 2 cases, angiotensin II
receptor antagonist (losartan) – 1 case, calcium channel antagonist (nifedipine) – 1
case, a selective β1 receptor blocker (metoprolol tartrate) – 1 case, and combined
drug (enalapril / hydrochlorothiazide) – 1 case. 2-5 days prior to the study
hypotensive therapy was cancelled. In case patients should have to continue taking
medicines they were not included.
All patients were examined before and after medical treatment of BA
exacerbation (time period between the first and next examination was 1.5-2 months).
Fasting blood sampling was performed before noon (845-900 am). Six hours before
blood sampling patients were not inhaling short-acting β2-agonists, and within 24
hours – prolonged β2-agonists. ET-1 levels in patients’ plasma were estimated by
using Enzyme Immunoassay test-kit for the quantitative determination of endothelin
(Biomedica Gruppe, Austria). Optical density of samples was measured by using
photometer “ELM-3000” (DRG, USA), at 450 nm wavelength and comparison
55
wavelength 620 nm. Respiratory function tests were performed by using Erich Jager
apparatus (Germany). Hemodynamic parameters were measured by using premier
cardiovascular ultrasound system GE VIVID7 Dimension (General Electric, USA).
Therapeutic regimen for BA patients included inhaled glucocorticosteroids and
β2-agonists (short-acting and prolonged); no systemic glucocorticosteroids were
applied. In case hypotensive therapy was necessary patients were given lisinopril (10
mg a day) and/or amlodipine (5 mg a day) or by using them as combination drug – 10
mg lisinopril plus 5 mg amlodipine, daily (35 patients, including 17 patients with BA
and concomitant EH stage I, and 18 patients with BA and concomitant EH stage II).
Statistical analysis was performed according to the general routine methods by
using software STATISTICA 6.0. All data are shown as mean value (М) ± SE (m).
Statistical significance between groups was calculated with a Student’s t-test. To
measure relationship between studied parameters we calculated correlation
coefficient (r).
R e s u l t s a n d D i s c u s s i o n . In Table 1 we show a distribution of
examined patients according to BA severity as well as the presence of concomitant
EH. There was found that BA severity was associated with higher probability of
concomitant EH.
Table 1
Distribution of examined patients according to
BA severity level and concomitant EH
Groups of
I
II
III
IV
Total
mBA
3 (66.6 %)
2 (33.3 %)
0
0
5 (100 %)
moBA
26 (46.4 %)
6 (10.0 %)
12 (21.4 %) 12 (21.4 %)
56 (100 %)
sBA
4 (21.1 %)
2 (10.6 %)
7 (36.8 %)
19 (100 %)
patients
6 (31.6 %)
During the treatment a positive dynamics of both airway flow index as well as
BP values was documented. In particular, we saw that during the second examination
prior to blood sampling patients with EH had systolic BP that decreased by 6.2±1.8
56
mmHg (4.7±2.8 mmHg in Group III and 7.5±2.5 mmHg in Group IV), whereas
diastolic BP decreased by 4.7±1.7 mmHg (3.1±2.8 mmHg in Group III and 6.1±2.1
mmHg in Group IV).
All examined patients did not show signs of severely increased pulmonary
artery systolic pressure (PASP) that was equal to 30.0±0.4 mmHg. No significant
differences were found in PASP values among groups with patients having mild,
moderate, or severe BA. PASP in Group I (28.1±0.7 mmHg) was slightly lower as
compared with patients from Group II (31.2±0.9 mmHg, p<0.05), Group III
(31.1±0.8 mmHg, p<0.01), Group IV (31.2±0.8 mmHg, p<0.01). After treatment was
completed no significant decrease in PASP was found.
When we measured serum ET-1 levels we did not reveal significant differences
between whole group of patients with BA (first and second examination) and control
group (Table 2).
Table 2
ET-1 serum level in examined patients, fmol/ml
Groups of patients
Before treatment
After treatment
BA, n=80
0.232±0.022
Control group, n=10
0.242±0.020
0.208±0.025
ET-1 serum level was not significantly different among patients with mild,
moderate or severe BA (Table 3).
Table 3
ET-1 serum level in examined patients according to
the BA severity level, fmol/ml
Groups of patients
Before treatment
After treatment
mBA, n=5
0.177±0.034
0.216±0.037
moBA, n=56
0.247±0.031
0.252±0.025
sBA, n=19
0.202±0.019
0.223±0.047
Control group, n=10
0.208±0.025
57
We found out that ET-1 serum level was significantly affected with associated
cardiovascular pathology (Table 4). After treatment there was shown that patients
from Group III and Group I had significant differences in ET-1 serum levels
(0.315±0.053 vs. 0.207±0.027 fmol/ml, respectively, p<0.05).
After treatment patients in Group III had higher ET-1 level in serum than
before treatment (0.315±0.053 vs. 0.196±0.022 fmol/ml, respectively, p<0.05).
Table 4
ET-1 serum level in BA patients according to concomitant EH, fmol/ml
Groups of patients
Before treatment
After treatment
I, n=33
0.224±0.038
0.207±0.027*
II, n=10
0.225±0.054
0.257±0.043
III, n=19
0.196±0.022§
0.315±0.053*§
IV, n=18
0.290±0.060
0.224±0.043
Control group, n=10
0.208±0.025
Comments. * – statistically significant differences between groups, p<0.05.
§
– statistically significant differences are found before and after treatment, p<0.05.
Previously there was shown that ET-1 levels may be increased in patients with
BA. In some cases ET-1 levels were tend to normalize while airway narrowing is
getting improved [3]. In our study we found that serum ET-1 level in BA patients was
comparable with that one from subjects of control group. At the same time, during
the first examination moderate significant correlation between ET-1 level and relative
increase of forced expiratory volume in 1 second (as compared with basic value) was
shown. For the whole group correlation coefficient was 0.29, р=0.011. Magnitude of
correlation was going up in parallel with BA severity level. In particular, correlation
was insignificant in patients with mild BA, whereas in case of moderate BA
correlation coefficient was reaching 0.32, р=0.019, and in patients with severe BA it
was reaching up to 0.46, р=0.049.
During the last 20 years a role of ET-1 in development and progression of
arterial hypertension has been widely debated. It is known that despite its vasopressor
capacity ET-1 was increased only in few patients with arterial hypertension [2],
58
including patients with pheochromocytoma [8], patients with arterial hypertension
associated with obesity [6]. Course of arterial hypertension may be ameliorated by
using angiotensin converting enzyme inhibitors, that can be accompanied with
decrease of ET-1 levels [4]. In our study we have found that ET-1 concentration after
treatment in BA patients with concomitant EH stage I was higher than in subjects
who had optimal or normal BP values.
However, it is worth mentioning that the serum ET-1 level in BA patients with
concomitant EH stage I was slightly increasing as BP value (and airway narrowing)
was becoming normalized. It might be due to the fact that duration of treatment
course was short. Consequently, there was not enough time spent between two
examination points (before and after treatment). Moreover, it is known [7] that in
human ET-1 mediates its bronchoconstrictive effect via B-type receptors (ЕТв).
When ET-1 acts on ЕTв receptors it mainly induces vasorelaxation rather than
vasoconstriction as compared with signaling via ЕTа receptors [10]. Previously there
was shown that in experimental conditions chronic hypoxia is characterized with
enhanced ET-1-mediated signaling via ЕTв receptors that leads not only to
bronchoconstriction but vasorelaxation as well [5]. It is possible that patients with
combined pathology might have increased ET-1 level at some stages that could be
accompanied with vasorelaxation. It is supported by the evidence that BA patients
with concomitant EH (Group III + IV) were found to have an inverse correlation
between ET-1 level after treatment and BP values, in particular, systolic (r=-0.38,
p=0.036) as well as diastolic (r=-0.38, p=0.037).
C o n c l u s i o n . We have found that in BA patients ET-1 level in blood
serum was dependent not only on the course of the respiratory disease, but also it was
affected by accompanying cardiovascular pathology. After treatment of BA
exacerbation patients with concomitant EH stage I were shown to have a higher
serum level of endothelin-1 as compared with patients who had normal or optimal BP
values.
References:
59
1. Böhm F., Pernow J. The importance of endothelin-1 for vascular dysfunction in
cardiovascular disease // Cardiovasc Res. – 2007. – V. 76. № 1. - P. 8-18.
2. Dhaun N., Goddard J., Kohan D.E., Pollock D.M., Schiffrin E.L., Webb D.J. Role
of endothelin-1 in clinical hypertension: 20 years on // Hypertension. – 2008. – V. 52.
- № 3. - P. 452-459.
3. Fagan K.A., McMurtry I.F., Rodman D.M. Role of endothelin-1 in lung disease //
Respir. Res. – 2001. - V. 2. - № 2. – Р. 90–101.
4. Hlubocká Z., Umnerová V., Heller S., Peleska J., Jindra A., Jáchymová M.,
Kvasnicka J., Aschermann M., Horký K. Is mild essential hypertension without
obvious organ complications and risk factors associated with increased levels of
circulating markers of endothelial dysfunction? Effect of ACE inhibitor therapy //
Vnitr. Lek. – 2002. – V. 48. - № 8. – Р. 718-723.
5. Lal H., Yu Q., Williams K.I., Woodward B. Hypoxia augments conversion of bigendothelin-1 and endothelin ET(B) receptor-mediated actions in rat lungs //Eur J
Pharmacol. – 2000. – V. 402. - № 1-2. Р. 101-110.
6. Letizia C., Celi M., Cerci S., Scuro L., Delfini E., Subioli S., Caliumi C., D'Erasmo
E. High circulating levels of adrenomedullin and endothelin-1 in obesity associated
with arterial hypertension // Ital. Heart J. Suppl. – 2001. - V. 2. - № 9. - Р 1011-1015
7. Naline E., Bertrand C., Biyah K., Fujitani Y., Okada T., Bisson A., Advenier C.
Modulation of ET-1-induced contraction of human bronchi by airway epitheliumdependent nitric oxide release via ETA receptor activation // Br. J. Pharmacol. - 1999
- V. 126. - № 2. – Р. 529–535.
8. Oishi S., Sasaki M., Sato T. Elevated immunoreactive endothelin levels in patients
with phaeochromocytoma // Am J Hypertens. – 1994. – V. 7. - № 8. – P. 717–722.
9. Polikepahad S., Moore R.M., Venugopal C.S. Endothelins and airways - a short
review // Res. Commun. Mol. Pathol. Pharmacol. – 2006. – V. 119. - № 1-6. – Р. 351.
10. Rich S., McLaughlin V.V. Endothelin receptor blockers in cardiovascular disease
// Circulation. – 2003. – V. 108. - № 18. – P. 2184-2190.
60
State Educational Establishment for Higher Professional Training «SaintPetersburg State I.P. Pavlov Medical University of the Federal Agency for Public
Health and Social Development of the Russian Federation». Russia, 197022, St.Petersburg, Lev Tolstoy str. 6/8. Tel. 8(812)499-71-53, fax 8(812)234-08-97.
Summary:
Serum levels of endothelin-1 were investigated in 80
asthmatic subjects. Serum level of endothelin-1 after the treatment of asthma
exacerbation was higher in patients with concomitant essential hypertension, stage I,
than in patients with optimal and normal blood pressure.
K e y w o r d s : bronchial asthma; essential hypertension; endothelin-1.
References
1. Böhm F. The importance of endothelin-1 for vascular dysfunction in
cardiovascular disease / F. Böhm, J. Pernow // Cardiovasc Res. – 2007. – Vol. 76. № 1. - P. 8-18.
2. Dhaun N. Role of endothelin-1 in clinical hypertension: 20 years on /
N. Dhaun, J. Goddard, D.E. Kohan // Hypertension. – 2008. – Vol. 52. - № 3. - P.
452-459.
3. Fagan K.A. Role of endothelin-1 in lung disease / K.A. Fagan,
I.F. McMurtry, D.M. Rodman // Respir. Res. – 2001. - Vol. 2. - № 2. – Р. 90–101.
4. Hlubocká Z. Is mild essential hypertension without obvious organ
complications and risk factors associated with increased levels of circulating markers
of endothelial dysfunction? Effect of ACE inhibitor therapy / Z. Hlubocká,
V. Umnerová, S. Heller // Vnitr. Lek. – 2002. – Vol. 48. - № 8. – Р. 718-723.
5. Lal H. Hypoxia augments conversion of big-endothelin-1 and endothelin
ET(B) receptor-mediated actions in rat lungs / H. Lal, Q. Yu, K.I. Williams,
B. Woodward // Eur. J. Pharmacol. – 2000. – Vol. 402. - № 1-2. Р. 101-110.
6. Letizia C. High circulating levels of adrenomedullin and endothelin-1 in
obesity associated with arterial hypertension / C. Letizia, M. Celi, S. Cerci // Ital.
Heart J. Suppl. – 2001. - Vol. 2. - № 9. – Р. 1011-1015.
7. Naline E. Modulation of ET-1-induced contraction of human bronchi by
airway epithelium-dependent nitric oxide release via ETA receptor activation /
61
E. Naline, C. Bertrand, K. Biyah // Br. J. Pharmacol. - 1999 - Vol. 126. - № 2. –
Р. 529–535.
8. Oishi S. Elevated immunoreactive endothelin levels in patients with
phaeochromocytoma / S. Oishi, M. Sasaki, T. Sato // Am. J. Hypertens. – 1994. –
Vol. 7. - № 8. – P. 717–722.
9. Polikepahad S. Endothelins and airways - a short review / S. Polikepahad,
R.M. Moore, C.S. Venugopal // Res. Commun. Mol. Pathol. Pharmacol. – 2006. –
Vol. 119. - № 1-6. – Р. 3-51.
10. Rich S. Endothelin receptor blockers in cardiovascular disease / S. Rich,
V.V. McLaughlin // Circulation. – 2003. – Vol. 108. - № 18. – P. 2184-2190.
Information about the authors:
Kozyrev Andrey Gennadievich - candidate of medical sciences, senior research
officer, Scientific Research Institute of Pulmonology, Saint-Petersburg State I.P.
Pavlov Medical University, work tel. 8(812)499-68-89, e-mail: kozyrev@bk.ru
Surkova Elena Arkadievna - candidate of medical sciences, senior research
officer, Center of Molecular Medicine, Saint-Petersburg State I.P. Pavlov Medical
University, work tel. 8(812)499-71-94, e-mail: easurkova@mail.ru
Gichkin Alexey Yurievich - candidate of medical sciences, senior research
officer, Scientific Research Institute of Pulmonology, Saint-Petersburg State I.P.
Pavlov Medical University, work tel. 8(812)499-68-65, e-mail: gich59@mail.ru
Perley Vitaliy Evgenievich - doctor of medicine, principal research officer,
Scientific Research Institute of Pulmonology, Saint-Petersburg State I.P. Pavlov
Medical University, work tel. 8(812)499-68-65, e-mail: viper1956@mail.ru
M a t e r i a l R e c e i v e d 19.02.2010 г.
1286 Гольдзон+
UDC 616.127 – 001.17 – 085 – 092.9
© M.A. Goldzon, V.T. Dolgikh, A.O. Girsh, 2010
62
Goldzon M.A., Dolgikh V.T., Girsh A.O. Contractile rat myocardial function
disorders at thermal trauma and ways of their correction // Preventive and clinical
medicine. – 2010. - № 2 (35). – Р.
State Educational Establishment of Higher Professional Training «Omsk State
Medical academy of the Federal Agency for Public Health and Social Development
of the Russian Federation», Russia, 644099, г. Omsk, Lenina str., 12, tel.: 8(381)22332-89.
S u m m а r y : Studied indicators of work of the isolated heart of the burnt
rats and their change at carrying out infusion therapies. Infringements of the
contraction functions of a myocardium at the burnt animals and their improvement
are revealed at combined infusion therapies.
K e y w o r d s : a thermal trauma; infusion therapy; the isolated heart.
References
1. Адмакин А.Л. Осложнения ожоговой болезни, их причины и коррекция
/ А.Л. Адмакин, С.А. Петрачков // II съезд комбустиологов России. Сборник
научных трудов. – М., 2008. - С. 97-98.
2. Вазина И.Р. Термическая травма: летальность, причины смерти,
диагностические ошибки и ятрогенные осложнения / И.Р. Вазина, С.Н. Бугров,
С.А. Бухвалов // II съезд комбустиологов России. Сборник научных трудов. –
М., 2008. - С. 11-13.
3. Зильбер А.П. Этюды критической медицины / А.П. Зильбер. – М.:
МЕДпресс-информ, 2006. – 568 с.
4. Николаев С.Б. Иммунометаболические эффекты агонистов опиоидных
рецепторов при экспериментальной ожоговой травме / С.Б. Николаев,
Н.А. Быстрова, Ю.Д. Ляшев // Курский научно-практический вестник «Человек
и его здоровье». – 2005. - № 3. – С. 16-23.
5. Fallen E.T. Apparatus for study of ventricular function and metabolism in
the isolated rat / E.T. Fallen, W.G. Elliott, R. Gorlin // J. Appl. Physiol. – 1967. –
Vol. 22. - № 4. - Р. 836-839.
Information about autors:
63
Dolgikh Vladimir Terentevich - doctor of medicine, professor head of the
Department of Pathologic Physiology with course of clinical pathophysiology of
Omsk state medical academy, tel.: 8(3812)23-03-78, e-mail: prof_dolgih@mail.ru
Girsh Andrey Ottovich - doctor of medicine, professor of chair of
anesthesiology, resuscitation and intensive therapy of Omsk state medical academy,
tel.: 8(3812)23-03-78, e-mail: agirsh@mail.ru
Goldzon Marina Alexandrovna - intern of chair of hospital therapy of Omsk
state medical academy, tel.: 8(904)329-46-50; e-mail: magi-net@rambler.ru
M a t e r i a l R e c e i v e d 09.02.2010 г.
1322 Белова+
UDC 616.72-002:616-092.9
© S.V. Belova, 2010
Belova S.V. Simulation of experimental arthritis // Preventive and clinical
medicine. – 2010. - № 2 (35). – Р.
Federal government agency «Saratov Research Institute of Traumatology and
Orthopedics», Russia, 410002, Saratov, Chernyshevsky str., 148. Tel.: 8(845)223-0413. e-mail: sarniito@yandex.ru
S u m m a r y : The possibility to model an experimental rheumatoid arthritis
by means of a new method (Patent RU 2351021) is demonstrated. A good
comparativeness
of
histological
manifestations,
hematological,
cytological,
biochemical and histomorphologic alterations by experimental animals and patients
with rheumatoid arthritis as well as reliability and rapidity of an adequate
reproduction of this pathology permits to recommend this new model for studying of
pathogenesis, improving of diagnostic,s methods and approving of various schemes
(with and without medicaments) of therapy of rheumatoid arthritis.
Key
treatment.
words:
rheumatoid arthritis; pathogenesis; diagnostics and
References
64
1. Гриневич Ю.А. Определение
иммунных
комплексов
в
крови
онкологических больных / Ю.А. Гриневич, А.И. Алферов // Лаб. дело. - 1984. № 8. – С. 493-496.
2. Карякина Е.В. Клиническое
значение
определения
гликозаминогликанов сыворотки крови и синовиальной жидкости при
ревматоидном артрите / Е.В. Карякина // Вопр. ревматологии. - 1982. - № 4. –
С. 31-34.
3. Насонова В.А. Ревматические болезни. Руководство для врачей /
В.А. Насонова, Н.В. Бунчук. - М.: Медицина, 1997. – 35 с.
4. Пат. № 2351021 РФ Способ моделирования экспериментального
ревматоидного артрита / С.В. Белова, Е.В. Карякина, Е.А. Кистнер; заявитель и
патентообладатель
Саратовский
Научно-исследовательский
институт
травматологии и ортопедии; опубл. 27.03.2009г., Бюл. № 9. – 5 с.
5. Шехтер А.Б. Оценка морфологических проявлений синовита у
больных ревматоидным артритом: Методические рекомендации / А.Б. Шехтер,
А.А. Крель, З.П. Ращупкин. - М., 1985. – 30 с.
6. Pettipher E.R. Leucocyte infiltration and cartilage proteoglycan loss in
immune arthritis in the rabbit / E.R. Pettipher, B. Henderson, S. Moncada, // Br. J.
Pharmacol. – 1988. – Vol. 95. - P. 169-176.
Information about the author:
Belova Svetlana Vyacheslavovna - Senior researcher, assistant of the
department of Laboratory and Functional Diagnostics of the Saratov Research
Institute of Traumatology and Orthopedics, tel.: 8(845)223-46-68, e-mail:
sarniito_bsv@mail.ru
M a t e r i a l R e c e i v e d 18.05.2010 г.
1295 Тарасов+
UDC 616.37-089.819843
© A.N. Tarasov, 2010
65
Tarasov A.N. Pancreas graft formation depending on conditions of its blood
supply // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
State educational institution of higher professional education «Kemerovo State
medical academy» Intermediate level surgery department, Russia, 650016,
Kemerovo, Oktyabrsky av., 22, tel: 8(384)239-63-96, 8(384)239-65-63. E-mail:
OKB2@yandex.ru
S u m m a r y : The literature and the results of own studies, which were
devoted to the segment transplant forming opportunities and the method’s choice of
pancreas crossing were presented in the experimental work. In connection with the
aim the features of organ angioarchitecture were studied in dependence on age and
body type. The materials and the methods of this survey are in line with strictly
determined protocols, out of which the results about pancreas angioarchitecture direct
dependence on age and donor body type were done, which can be used in clinics of
pancreas disease in future.
K e y w o r d s : experiment; pancreas; angioarchitecture; transplantation.
References
1. Данилов М.В. Хирургия поджелудочной железы / М.В. Данилов,
В.Д. Федоров. - М.: Медицина, 1995. - 512с.
2. Кокс Д. Прикладная статистика. Принципы и примеры / Д. Кокс,
Э. Снелл. - М.: Мир, 1984. - 200с.
3. Эндоскопическая ультрасонография в диагностике хирургических
заболеваний поджелудочной железы / Ю.Г. Старков [и др.] // Хирургия. - 2008.
- №1. - С.47-52.
4. Ariyama J. Endoscopic ultrasound and intraductal ultrasound in the
diagnosis of small pancreatic tumors / J. Ariyama, M. Suyama, K. Satoh // Abdom
Imaging. – 1998. – Vol. 23. – Р. 380-386.
5. Penman I.D. Endoscopic ultrasound / I.D. Penman // Endoscopy. – 2001. Vol. 33. – Р. 940-948.
66
6. Saftoiu A. Endoscopic ultrasound elastography – a new imaging technique
for the visualization of tissue elasticity distribution / A. Saftoiu, P. Vilman // J.
Gasroinestin liver dis. – 2006. - Vol. 15. - №2. – Р. 161-165.
Information about the author:
Tarasov Andrey Nikolaevich the post-graduate student of chair of faculty
surgery of the «Kemerovo state medical academy», work tel.: 8(3842)39-65-63, email: tarassov@kuzbass.net
M a t e r i a l R e c e i v e d 26.02.2010 г.
1246 Комяков+
UDC 613.6:677
© B.K. Komyakov, B.G. Guliev, R.G. Shibliev, M.Yu. Alekseev, 2010
Komyakov B.K., Guliev B.G., Shibliev R.G., Alekseev M.Yu. Complications of
percutaneous nephrolithotripsy // Preventive and clinical medicine. – 2010. - № 2
(35). – Р.
State educational institution of higher professional education «St. Petersburg
State Medical Academy named after I.I. Mechnikov». Russia, 195067, St. Petersburg,
Piskarevsky pr., 47, tel./fax: 8(812)543-01-26, e-mail: mechnik@gmail.com
S u m m a r y : Results of percutaneous treatment of 458 patients with renal
stones. From them open surgical interventions are made 157 (68,3%), endoscopic
treatment - 52 (22,6%) and nephroectomy - 21 (9,1%) to the patient. The good longterm results plastic interventions on ureteropelvic junction have been received at 114
(82,6%), after endoscopic interventions only at 39 (75,0%) patients. Percutaneous
interventions are shown at secondary strictures of ureteropelvic junction, when
performance of open surgical interventions are technically inconvenient, and at
patients with a unique kidney are very dangerous.
K e y w o r d s : renal stones; percutaneous treatment; complication.
Список литературы
67
1. Мартов А.Г. Рентген-эндоскопические методы диагностики и лечения
заболеваний почек и верхних мочевых путей (суправезикальная эндоурология).
Автореф. дисс. … д-ра мед. наук. – М., 1993. – 76 с.
2. Cortellini P. Major complications of percutaneous
nephrolithotripsy
(PCNL). Analysis of our cases / P. Cortellini, A. Frattini, S. Ferretti // Minerva Urol
Nefrol. – 1997. –Vol. 49. - № 4. – P. 203–236.
3. Gremmo
E.
Hemorrhagic
complications
during
percutaneous
nephrolithotomy. Retrospective studies of 772 cases / E. Gremmo, P. Ballanger,
B. Dore // Prog Urol. – 1999. – Vol. 3. – P. 460–463.
4. Kondas
J.
Splenic
injury:
a
rare
complication
of
percutaneuos
nephrolithotomy / J. Kondas, E. Szentgyorgyi, L. Vaczi // Int. Urol. Nephrol. – 1994.
– Vol. 26. - № 4. – P. 399–404.
5. Konishi T. Renal pseudoaneurysm successfully treated by superselective
embolization as a complication of percutaneous nephrolithotomy: report of a case /
T. Konishi, M. Kokuho, M. Narita // Hinyokika Kiyo. – 1991. – Vol. 37. - № 10. –
P. 1299–1302.
6. Looser C. The catheter embolization of acute hematuria after percutaneous
nephrostomy and nephrolitholapaxy / C. Looser, J. Triller, D. Ackermann // Rofo. –
1992. – Vol. 157. - № 5. – P. 490–494.
7. Nakata F. Septic attack during percutaneous nephrolithotripsy under
epidural anesthesia / F. Nakata, H. Yamamoto, M. Okada // Masui. – 1993. –Vol. 42.
- № 6. – P.931–932.
8. Narasimham D.L. Percutaneous nephrolithotomy through an intercostal
approach / D.L. Narasimham, B. Jacobsson, P. Vijayan // Acta Radiol. – 1991. –
Vol. 32. - № 2. – P. 162–165.
9. Patel A. Air travel and thromboembolic complications after percutaneous
nephrolithotomy for staghorn stone / A. Patel, G.J. Fuchs // J. Endourol. –1998. –
Vol. 12. - № 1. – P. 51–53.
68
10. Radecka E. Complications associated with percutaneous nephrolithotripsy:
supra – versus subcostal access. A retrospective study / E. Radecka, M. Brehmer,
K. Holmgren // Acta Radiol. – 2003. – Vol. 44. - № 4. – P. 447–451.
11. Ugras M. Severe renal bleeding caused by a ruptured renal sheath: case
report of a rare complication of percutaneous nephrolithotomy / M. Ugras, A. Gunes,
C. Baydinc // BMC Urol. – 2002. – Vol. 18. - № 1-2. – P. 10.
12. Wang J.H. Pyeloduodenal fistula: report of 2 cases / J.H. Wang,
J.H. Chiang, T. Chang // J. Formos. Med. Assoc. – 1990. – Vol. 89. - № 12. –
P. 1111-1114.
13. Wolf J.S. Management of intraoperatively diagnosed colonic injury during
percutaneous nephrolithotomy / J.S. Wolf // Tech Urol. – 1998. – Vol. 4. - № 3. –
P. 160–164.
Information about the authors:
Komyakov Boris Kirillovich - doctor of medicine, professor of the Department
of Urology St. Petersburg State Medical Academy named after I.I. Mechnikov, work
tel.: 8(812)510-94-33, E-mail: komyakovbk@mail.ru
Guliev Bakhman Gidayatovich – doctor of medical sciences, docent of the
Department of Urology St. Petersburg State Medical Academy named after
I.I. Mechnikov, work tel.: 8(921)945-34-80.
Shibliev Rustam Gudbiddinivich - the post-graduate student of the Department
of Urology St. Petersburg State Medical Academy named after I.I. Mechnikov, Tel.:
8(950)011-64-24, E-mail.: shibliyev@mail. ru
Alexeev Michail Yurevich - the post-graduate student of the Department of
Urology St. Petersburg State Medical Academy named after I.I. Mechnikov, Tel.:
8(921)950-37-27.
M a t e r i a l R e c e i v e d 17.11.2009 г.
1326 Александрова+
UDC 616 – 005.4:59.086
69
© L.A. Alexandrova, A.A. Zhloba, E.L. Blashko, S.G. Chefu, N.V. Kuzmenko,
V.A. Tsirlin, 2010
Alexandrova L.A.1,2, Zhloba A.A.1,2, Blashko E.L.1,2, Chefu S.G.,1,2 Kuzmenko
N.V.2, Tsirlin V.A.1,2 Methabolism of aminothiols and antioxidant status in rats under
experimental renal ischemia // Preventive and clinical medicine. – 2010. - № 2 (35). –
Р.
1
State educational institution of higher professional education «Saint-
Petersburg Pavlov State Medical University, Ministry of Health Care and Social
Development». Russia, 197022, St.-Petersburg, Lev Tolstoy str., 6/8, tel.: 8(812)49971-53, fax: 8(812)234-01-25, e-mail: feedback@spbmedu.ru
2
Almazov Federal Heart, Blood and Endocrinology Centre, Akkuratova str., 2,
Saint-Petersburg, Russia, 194341, Phone: 8(812)702-37-00, e-mail: info@hbecentre.ru
S u m m a r y : The present study examined the relationship between
aminothiol metabolism and antioxidant status in plasma and kidney after one-sided
ischemia of rat kidney. The experimental date showed stable intermediate
hyperhomocysteinemia, which positive correlated with malonyl dialdehyde
concentration and negative correlated with SH-groups concentration in the ischemic
kidney. The increased gamma-glutamyl transferase activity and superoxide dismutase
activity negatively correlated in ischemic kidney.
Key
w o r d s : hyperhomocysteinemia; antioxidant status; ischemia;
kidneys.
References
1. Александрова
Л.А.
Оценка
антиоксидантной
эффективности
фитотерапии больных дисциркуляторной энцефалопатией / Л.А. Александрова,
М.Л. Поспелова, О.Д. Барнаулов // Ученые записки СПбГМУ им. И.П.Павлова.
– 2000. – Т. 7, № 4. – С. 73-77.
2. Королев Д.В. Программный комплекс для исследования зависимости
артериального, перфузионного давления и сигнала ЭКГ от различных
воздействий / Д.В. Королев, И.В. Александров, Д.Л. Сонин, М.М. Галагудза // В
70
сб. «Математические методы в технике и технологиях ММТТ – XV». – Тамбов:
Тамбовский государственный технический университет – 2002. – Т. 7. – С. 155156.
3. Чиж А.С. Нефрология в терапевтической практике / А.С. Чиж. – М.:
Высшая школа, 1998. – 557 с.
4. Dominici S. Prooxidant reactions promoted by soluble and cell-bound
gamma-glutamyltransferase
activity
/
S. Dominici,
A. Paolicchi,
A. Corti,
E. Maellaro // Methods enzymol. – 2005. – Vol. 401. – P. 484-501.
5. Hell F. Angiotesin II-induced calcium signaling in the afferent arteriole from
rats with two-kidney, one-clip hypertension / F. Hell, Q.B. Vagnes, B.M. Iversen //
Am. J. Physiol. Renal. Physiol. – 2006. – Vol. 291. – № 1. – P. 140-147.
6. Graham M. Plasma homocysteine as a risk factor for vascular disease: the
European concerted action project / M. Graham, L. Daly, H. Refsum // JAMA. –
1997. – Vol. 277. – № 22. – P. 1775-1781.
7. Lee D.H. Is serum gamma glutamyltransferase a marker of oxidative stress?
/ D.H. Lee, B. Rune, D. Jacobs // Free Radical Research – 2004. – Vol. 38. – № 6 –
P. 535–539.
8. Perna A.F. Homocysteine and oxidative stress / A.F. Perna, D. Ingrosso,
N.G. De Santo // Amino Acids. – 2003. – Vol. 25. – P. 409-417.
9. Pompella A. The significance of serum gamma-glutamyltransferase in
cardiovascular diseases / A. Pompella, M. Emdin, C. Passino, A. Paolicchi // Clin.
Chem. Lab. Med. – 2004. – Vol. 42. – № 10. – P. 1085-1091.
10. Zhloba A.A. Liquid chromatographic determination of total homocysteine
in blood plasma with photometric detection / A.A. Zhloba, E.L. Blashko // J.
Chromatogr. B. Analyt. Technol. Biomed. Life Sci. – 2004. – Vol. 800. – № 1. –
P. 275-280.
Information about the authors:
Alexandrova Ludmila Alexandrovna – candidate of biological sciences, senior
research scientist of the Biochemistry department of Scientific Research Center St.Petersburg Pavlov State Medical University and Group of proteomics Institute of
71
Molecular
Biology
and
Genetics,
work
tel.:
8(812)499-71-08,
e-mail:
alexandroval@spmu.rssi.ru
Zhloba Alexandr Anatolievich – doctor of medicine, professor, head of the
Biochemistry Department of Scientific Research Center St.-Petersburg Pavlov State
Medical University, and Group of proteomics Institute of Molecular Biology and
Genetics, work tel.: 8(812)499-71-08, e-mail: ovinokur@spmu.rssi.ru
Blashko Eduard Lvovich – candidate of biological sciences, senior research
scientist of the Biochemistry department of Scientific Research Center St.-Petersburg
Pavlov State Medical University and Group of proteomics Institute of Molecular
Biology and Genetics, work tel.: 8(812)499-71-08, e-mail: ovinokur@spmu.rssi.ru
Chefu Svetlana Grigorievna – candidate of biological sciences, head of the
Laser Medicine Center St.-Petersburg Pavlov State Medical University, and senior
research scientist of The Scientific Research Laboratory of microcirculation Almazov
Federal Heart, Blood and Endocrinology Centre, work tel.: 8(812)499-70-35, e-mail:
chefusveta@yandex.ru
Kuzmenko Natalia Vladimirovna – candidate of biological sciences, senior
research scientist of Scientific Research Division of experimental physiology and
pharmacology Institute of Experimental Medicine, Almazov Federal Heart, Blood
and Endocrinology Centre tel.: 8(812)550-07-00.
Tsirlin V.A. – doctor of medicine, professor, head of Scientific Research
Division of experimental physiology and pharmacology Institute of Experimental
Medicine Almazov Federal Heart, Blood and Endocrinology Centre, tel.: 8(812)55007-00.
M a t e r i a l R e c e i v e d 01.06.2010 г.
1304 Белокрылов+
UDC 616.718.41-002.4-089
© N.M. Belokrylov, O.V. Gonina, N.V. Polyakova, N.A. Pekk, 2010
72
Belokrylov N.M., Gonina O.V., Polyakova N.V., Pekk N.A. Choice of optimum
tactics for treatment of Legg-Kalve-Perthes disease // Preventive and clinical
medicine. – 2010. - № 2 (35). – Р.
Public health services municipal hospital №9 named after M.A. Tverye.
Russia, 614990, Perm, Brothers Ignatov str., 2, tel.: 8(342)221-75-20.
Summary:
A 20-year experience of treatment of 282 children with
Legg-Kalve-Perthes’ disease is presented. 180 patients were conservatively treated,
102 (36%) were operated on. Residual anatomic defects were found in 46% of cases
with a 2nd and 3rd stages of the disease. Early conservative treatment and correction of
deformations at the 4th and 5th stages of the disease were preferred. Тhe positive
outcomes after surgical treatment were noted 95%.
K e y w o r d s : coxofemoral joint; Legg-Kalve-Perthes disease; femur head
osteochondropathy; pelvic osteotomy; femur osteotomy.
References
1. Барсуков Д.Б. Ортопедохирургическое лечение детей с болезнью ЛеггаКальве-Пертеса / Д.Б. Барсуков: Дисс…. канд. мед. наук. – СПб., 2003. - 245 с.
2. Барсуков Д.Б. Ошибки в выборе тактики и метода лечения детей с
болезнью Пертеса / Д.Б. Барсуков, А.И. Краснов // Оптимальные технологии
диагностики и лечения в детской травматологии и ортопедии, ошибки и
осложнения: Материалы симпозиума детских травматологов-ортопедов России
(Волгоград). – СПб., 2003. - С. 234-236.
3. Белецкий А.В. Остеотомии бедра при лечении болезни Пертеса у детей /
А.В. Белецкий, М.Н. Корень // Материалы итоговой научно-практической
конференции. - Минск, 1995. - С. 55-56.
4. Овчинников Г.И. Медицинская реабилитация больных асептическим
некрозом головки бедренной кости / Г.И. Овчинников: Автореф. дисс…. докт.
мед. наук. – Киев, 1991. – 34 с.
5. Тимофеева
М.И.
Функциональное
обоснование
новых
методов
оперативного лечения болезни Пертеса у детей / М.И. Тимофеева: Автореф.
дисс…. докт. мед. наук. - Пермь, 1991. – 39 с.
73
6. Цыкунов М.Б. Методика клинической оценки функционального
состояния тазобедренного сустава у детей и подростков / М.Б. Цыкунов,
М.А. Еремушкин, В.Д. Шарпарь // Вестник травматологии и ортопедии имени
Н.Н. Приорова. – 2001. - № 3. – С. 13-18.
7. Mose K. Methods of measuring in Legg-Calve-Perthes diasease with special
regard to the prognosis / K. Mose // Clin. Orthop. – 1980. – № 150. – P. 103-109.
Information about the authors:
Belokrylov Nikolay Mihajlovich - doctor of medicine managing department of
children's orthopedy and traumatology of Public health services municipal hospital
№ 9 named after M.A. Tverye, main children's traumatologist-orthopedist of the
Ministry of Health of the Perm region, office number: 8(342)221-82-80, e-mail:
belokrylov1958@mail.ru
Gonina Olga Valerevna - the candidate of medical sciences, the doctor, the
traumatologist-orthopedist of department of children's orthopedy and traumatology
of Public health services municipal hospital № 9 of M.A. Tverye № 9 named after
M.A. Tverуe, office number: 8(342)221-65-90.
Polyakova Natalia Vladimirovna - the candidate of medical sciences, the
doctor, the traumatologist-orthopedist of department of children's orthopedy and
traumatology of Public health services municipal hospital № 9 named after
M.A. Tverуe, office number: 8(342)221-65-90.
Pekk Natalya Aleksandrovna - the doctor, the traumatologist-orthopedist of
department of children's orthopedy and traumatology of Public health services
municipal hospital № 9 named after M.A. Tverуe, office number: 8(342)221-65-90.
M a t e r i a l R e c e i v e d 16.03.2010 г.
1235 Арсеньев+
UDC 616.65-006-07+616.65-007.61-07
© A.A. Arsenev, B.V. Dmitriev, V.K. Makarov, 2010
74
Arsenev A.A., Dmitriev B.V., Makarov V.K. Immunoreactivity features in
patients with benign prostate hyperplasia and prostate adenocarcinoma // Preventive
and clinical medicine. – 2010. - № 2 (35). – Р.
State educational institution of higher professional education «Tver State
Medical Academy». Russia, 170100, Tver, Sovetskaya str., 4. Тel.: 8(4822)32-17-79,
fax: 8(4822)34-43-09. Е-mail: info@tvergma.ru
S u m m a r y : Clinical blood analysis of patients with prostate cancer showed
significant leucocyte decrease. Features of immunoreactivity in patients with benign
prostate hyperplasia include immune lack of CD8 and CD19 cells. While in patients
with prostate cancer there was more marked decrease of CD3, CD4, CD8 and CD19
lymphocytes.
Key
w o r d s : benign prostate hyperplasia; prostate cancer; immune
reactivity.
References
1. Клиническая онкоурология / под ред. Б.П. Матвеева. – М.:Вердана,
2003. - 457с.
2. Лимфоциты / под ред. Дж. Клауса. – М.: Мир, 1990. – 95 с.
3. Урология / под ред. Н.А. Лопаткина. - М.: ГЕОТАР-МЕДИА, 2007. –
265 с.
4. Guess H.A. Epidemiology and natural history of benign prostatic hyperplasia
/ H.A. Guess // Urol. Clin. North. Am. - 1995. - Vol. 22. - P. 247-261.
5. Quinn M. Patterns and trends in prostata cancer incidence, survival,
prevalence and mortality / M. Quinn, P. Babb // International comparisons BJU. Int. 2002. - Vol. 90. - № 2. - Р. 162-173.
Сведения об авторах:
Information about the authors:
M a t e r i a l R e c e i v e d 31.10.2009 г.
1328 Селиверстов+
UDC 616.34-008.87-07:616.36-002.2
75
© P.V. Seliverstov, L.A. Teterina, V.G. Radchenko, S.I. Sitkin, A.N. Suvorov,
G.G. Alekhina, 2010
Seliverstov P. V., Teterina L.A., Radchenko V. G., Sitkin S.I., Suvorov A.N.,
Alekhina G.G. Aged changes in the gastrointestinal tract in patients with disbiosis of
the large intestine on the background of liver chronic diseases // Preventive and
clinical medicine. – 2010. - № 2 (35). – Р.
1
Federal Agency for Public Health and Social Development State Educational
Establishment for Higher Professional Training «Mechnikov’s Saint-Petersburg State
Medical Academy» (SEE YPT SPSMA named after Mechnikov Rosgoszdrav).
Russia, 195067, Saint-Petersburg, Piskarevsky pr., 47. Tel.: 8(812)543-96-09, fax:
8(812)740-15-24. Е-mail: mechnik@mail.ru
2
Institute of Experimental Medicine of the NorthWest Branch of the Russian
Academy of Medical Sciences ( IEM NWB RAMS). Russia, 197376, St.Petersburg,
akad.Pavlov str.,12. Phone: 8(812)234-68-68, fax: 8(812)234-94-89. Е-mail:
iem@iemrams.ru, iem@iem.spb.ru
3
Limited
company
Kamennoostrovsky
prospect,
«Avena»,
71.
Russia,
Phone:
194100,
St.Petersburg,
8(812)234-68-65.
Е-mail:
avena@mail.wplus.net
Summary:
In the process of vital activity every human organism
undergoes a number of changes leading to its aging. The serious changes in all
internal organs, including the gastrointestinal tract occur. Nowadays, the
effectiveness of «Laminolakt» appears to be sufficiently high for the correction of
disbiosis against the background of the chronic diseases of the liver, in patients over
60 y.o. (years of age). «Laminolakt» has both local and general systemic antipyretic
effect.
K e y w o r d s : Laminolakt; aging; disbiosis; the liver.
References
1. Барановский А.Ю. Основы питания россиян / А.Ю. Барановский,
Л.И. Назаренко. – СПб.: Питер, 2007. – 528 с.
76
2. Барановский А.Ю. Болезни обмена веществ / А.Ю. Барановский. –
СПб.: СпецЛит, 2002. – 235 с.
3. Барановский А.Ю. Болезни пожилых / А.Ю. Барановский – М.: ЗАО
«Центрполиграф», 2002. – 633 с.
4. Барановский
А.Ю.
Клиническое
питание
/
А.Ю. Барановский,
К.Л. Райхельсон. - М.: ЗАО «Центрполиграф», 2008. – 21 с.
5. Барановский
А.Ю. Диетология:
Руководство.
3-е
изд.
/
А.Ю. Барановский. – СПб.: Питер-Юг, 2008. – 960 с.
6. Валенкевич Л.Н. Гастроэнтерология в гериатрии / Л.Н. Валенкевич. –
Л.: Медицина, 1987. – 240 с.
7. Воробьев В.И. Организация оздоровительного и лечебного питания /
В.И.Воробьев. – М.: Медицина, 2002. – 15 с.
8. Дворецкий Л.И. Справочник по диагностике и лечению заболеваний у
пожилых / Л.И. Дворецкий, Л.Б. Лазебник. – М.: ООО "Издательство Новая
Волна", 2000. – 543 с.
9. Коркушко О.В. Гериатрия в терапевтической практике / О.В. Коркушко,
Д.Ф. Чеботарев, Е.Г. Калиновская. – Киев: Здоров′я, 1993. – 840 с.
10. Лисовский В.А. Экология и питание / В.А. Лисовский, З.Я. Зандукели,
И.М. Мухин . – СПб.: Лениздат, 1998. – 254 с.
11. Покровский А.А. Беседы о питании / А.А. Покровский. – М.:
Медицина, 1968. – 188 c.
12. Смолянский Б.Л. Диетология. Новейший справочник для врачей /
Б.Л. Смолянский, В.Г. Лифляндский. – СПб.: Сова; М.: Издательство Эксмо,
2003. – 816 с.
Information about the authors:
Seliverstov Pavel Vasilievich – assistant of the department of Internal Diseases
with the course of Therapy and Nephrology of the faculty for Advanced Training of
the SPSMA named after I.I. Mechnikov. Work tel.: 8(812)543-05-86, e-mail:
Seliverstov-PV@yandex.ru
77
Teterina Ludmila Anatolievna– aspirant of the department of Internal Diseases
with the course of Therapy and Nephrology of the faculty for Advanced Training of
the SPSMA named after I.I. Mechnikov. Work tel.: 8(812)543-05-86, e-mail:
lorein06@mail.ru
Sitkin Stanislav Igorevich – candidate of Medical Sciences, docent of the
department of Propedeutics with the course of Gastroenterology and Internal
Diseases of the SPSMA named after I.I. Mechnikov. Work tel.: 8(812)543-04-60, email: gastro@peterlink.ru
Radchenko Valerii Grygorievich – professor of the department of Internal
Diseases with the course of Therapy and Nephrology of the faculty for Advanced
Training of the SPSMA named after I.I. Mechnikov. Work tel.: 8(812)543-05-86, email: SZGC@yandex.ru
Suvorov Alexander Nikolaevitch – head of the lab of molecular microbiology
of pathogenic microbes, doctor of medical sciences, professor of microbiology.
Institute
of
Experimental
Medicine.
Work
tel.:
8(812)234-93-19,
e-mail:
Suvorov.Alexander@yahoo.com
Alechina Galina Gennadievna – LLC Avena. Director of the company, MD,
PhD. Work tel.:8(812)234-68-65, e-mail: Avena@mail.wplus.net
M a t e r i a l R e c e i v e d 01.06.2010 г.
1329 Абдулаев+
UDC 616.33-002.45-08+616.342-002.45-08
© M.A. Abdulaev, Yu.V. Plotnikov, A.M. Mukhanna, 2010
Abdulaev M.A.2, Plotnikov Yu.V.1, Mukhanna A.M.1 Еarly results of treatment
of patients with perforated gastroduodenal ulcers // Preventive and clinical medicine.
– 2010. - № 2 (35). – Р.
1
State Educational institution of higher education «Saint-Petersburg State
Medical Academy named after I.I.Mechnikov of the Federal Agency for Public
Health and Social Development». Russia, 195067, St.-Petersburg, Piskarevckу pr.,
47. Теl.: 8(812)543-94-20, fax: 8(812)545-47-53. Е-mail: mechnik@gmail.com
78
2
The State Alexander Hospital, Russia, 191015, St.-Petersburg, Solidarnosti
av., 4. Теl.: 8(812)589-16-30, fax: 8(812)589-11-41. E-mail: info@alexhospital.ru
Summary:
Monitoring
analyzed
290
patients
with
perforated
gastroduodenal ulcers. 64% of the patients underwent laparoscopic suture perforation
holes, 28% - traditional laparotomic access. The frequency of postoperative
complications of laparoscopic surgery was significantly lower (χ2 = 43,6; P <0,001),
and also significantly reduced mortality in the postoperative period (χ2 = 20,4; P
<0,001).
K e y w o r d s : perforative ulcer; laparoscopic suture; traditional access.
References
1. Бачев И.И. Хирургическая тактика при кровоточащих язвах желудка и
двенадцатиперстной кишки / И.И. Бачев // Хирургия. – 1991. - № 9. – С. 137143.
2. Борисов
А.Е.
Лапароскопическое
ушивание
перфоративных
гастродуоденальных язв. 3-й Всероссийский съезд по эндоскопической
хирургии: Тезисы докладов. / А.Е. Борисов, С.Е. Митин, С.И. Пешехонов //
Эндоскоп. хир. – 2000. - № 2. – С. 12-13.
3. Григорьев
П.Я.
Краткое
формулярное
руководство
по
гастроэнтерологии и гепатологии / П.Я. Григорьев, Э.П. Яковенко. - М., 2003. 112 с.
4. Ефименко Н.А. Перфоративные гастродуоденальные язвы: Патогенез
осложнений, их профилактика и лечение / Н.А. Ефименко, Ю.М. Стойко,
А.А. Курыгин. - М., СПб., 2001. – 192 с.
5. Исаков В.А. Предложения по использованию рекомендаций второго
Маастрихтского соглашения по эрадикации Helicobacter pylori / В.А. Исаков,
П.Л. Щербаков // Клинические перспективы гастроэнтерологии, гепатологии. 2002. - № 4. - С. 31-34.
6. Опыт применения малоинвазивных вмешательств с использованием
лапароскопической
техники
при
осложнениях
язвенной
болезни
79
двенадцатиперстной
кишки
/
Ю.М. Панцырев
[и
др.]
//
Рос.
журн.
гастроэнтерол. гепатол. колопроктол. – 2000. - № 6. – С. 65-68.
7. Панцырев Ю.М. Хирургическое лечение прободных и кровоточащих
гастродуоденальных язв / Ю.М. Панцырев, А.И. Михалев, Е.Д. Федоров //
Хирургия им Н.И. Пирогова. – 2003. –№ 3. - С. 43-49.
Information about the authors:
Magomed Abdulayev Abdulaevich - doctor of Medical Sciences, professor of
surgical disease with a course of pediatric surgery. Head first to the surgical
department of St. Petersburg Alexander City hospital. Tel.: 8(921)908-16-16, E-mail:
abdulla7@list.ru
Plotnikov Yuri Vladimirovitch - doctor of Medical Sciences, professor of
surgical disease with a course of pediatric surgery. Tel.: 8(953)3466342 E-mail:
plotnikster@gmail.com
Mukhanna Abdulla Mohammad - post-graduate department of surgical disease
with
a
course
of
pediatric
surgery.
Tel.:
8(906)275-42-23
E-mail:
muhannaam@yandex.ru
M a t e r i a l R e c e i v e d 01.06.2010 г.
1332 Чупров+
UDC 616.5-006.6-018
© I.N. Chuprov, S.V. Klyucharyova, V.L. Romanova, 2010
Chuprov I.N.1, Klyucharyova S.V.2, Romanova V.L.2 Parenchymal basal
membrane in various types of the skin basal cell carcinoma // Preventive and clinical
medicine. – 2010. - № 2 (35). – Р.
1
State Educational Establishment for Additional Professional Training «Saint-
Petersburg Medical Academy for Post-Diploma Training of the Federal Agency for
Public Health and Social Development of the Russian Federation», Russia, 191015,
Kirochnaya
str.,41,
tel.:8(812)
272-52-06,
fax:
8(812)273-00-39,
e-mail:
admin@maps.spb.ru
2
Federal Agency for Public Health and Social Development State Educational
Establishment for Higher Professional Training «Mechnikov Saint-Petersburg State
80
Medical Academy» (SEE YPT SPSMA named after Mechnikov Rosgoszdrav).
Russia, 195067, Saint-Petersburg, Piskarevsky pr., 47. Tel.: 8(812)543-96-09, fax:
8(812)740-15-24, e-mail: mechnik@mail.ru
S u m m a r y : The immunohistochemical study of the main components of
the parenchymal basal membrane - collagen IV and E-cadherin in different types of
the skin basal cell carcinoma was carried out. Most prominent basement membrane`s
disruptions was dominated in aggressive infiltrative BCC (p=0,008).
Key
words:
skin;
basal
cell
carcinoma;
basal
membrane;
immunohistochemistry.
References
1. Аничков Н.М. Биология опухолевого роста (молекулярно-медицинские
аспекты) / Н.М. Аничков, И.М. Кветной, С.С. Коновалов. – СПб.: ПраймЕВРОЗНАК, 2004. – 224 с.
2. Дерматоонкология / под ред. Г.А. Галил-Оглы, В.А. Молочкова,
Ю.В. Сергеева. − М.: Медицина для всех, 2005. − 872 с.
3. Дубенский В.В. Современные аспекты эпидемиологии, патогенеза,
клиники и лечения базально-клеточного рака кожи / В.В. Дубенский,
А.А. Гармонов // Вестник дерматологии и венерологии. − 2004. − № 6. −
С. 7−12.
4. Особенности инвазии базально-клеточного рака / Н.Г. Дойкова [и др.] //
Архив патологии. − 2000. − № 3. − С. 29−33.
5. Снарская Е.С. Базалиома / Е.С. Снарская, В.А. Молочков. − М.:
Медицина, 2003. − 324 с.
6. Хлебникова А.Н. Клинико-морфологические и иммуногистохимические
особенности различных форм базальноклеточного рака кожи и комплексный
метод его лечения : автореф. дис. …д-ра мед. наук : 14.00.11, 14.00.15 /
А.Н. Хлебникова. – М., 2007. – 37 с.
7. Bedeutung der Basalmembran fur das Wachstum von Tumoren –
Immunhistochemische Aspekte unter besonderer Berucksichtigung von Tumoren des
Kopf / A. Nerlich [et al.] // Laryngorhinootologie. − 1994. − № 12. − P. 631−636.
81
8. Evaluation of basement membrane status in aggressive skin carcinomas with
skull base invasion: a case-control study / C.R. Cernea [et al.] // Ann Diagn Pathol. −
2005. − № 3. − P. 130−133.
9. Expression of beta-catenin in basal cell carcinoma / M. El-Bahrawy [et al.] //
Br J Dermatol. − 2003. − № 5. − P. 964−970.
10. Expression of desmoglein I and plakoglobin in skin carcinomas / H. Tada
[et al.] // J Cutan Pathol. − 2000. − № 1. − P. 24−29.
11. Kirihara Y. Clinicopathological and immunohistochemical study of basal
cell carcinoma with reference to the features of basement membrane / Y. Kirihara,
J. Haratake, A. Horie // J Dermatol. − 1992. − № 3. − P. 161−169.
12. Panuncio A. Immunohistochemical study of nerve fibres in basal cell
carcinoma / A. Panuncio, R. Vignale, G. Lopez // Eur J Dermatol. − 2003. − № 3. −
P. 250−253.
13. Quatresooz P. Differential expression of alpha1 (IV) and alpha-5 (IV)
collagen chains in basal-cell carcinoma / P. Quatresooz, O. Martalo, G.E. Pierard // J
Cutan Pathol. − 2003. − № 9. − P. 548−552.
14. Takeuchi T. Downregulation of expression of a novel cadherin molecule, Tcadherin, in basal cell carcinoma of the skin / T. Takeuchi, S.B. Liang, Y. Ohtsuki //
Mol Carcinog. − 2002. − № 4. − P. 173−179.
15. The expression of nectin-1alpha in normal human skin and various skin
tumours / H. Matsushima [et al.] // Br J Dermatol. − 2003. − № 4. − P. 755−762.
Information about authors:
Chuprov Igor Nikolaevich - Candidate of Medical Sciences, AssistantProfessor, Saint-Petersburg Medical Academy for Post-Diploma Training, tel.:
8(921)387-03-78, 8(904)619-74-21, e-mail: igorchuprov@gmail.com
Klyuchareva Svetlana Victorovna - Doctor of Medicine, Professor of the
department of Dermatovenerology of the I.I.Mechnikov Saint-Petersburg State
Medical Academy. Tel.: 8(92)-747-30-85. E-mail: genasveta@rambler.ru
82
Romanova Victoriya Leonidovna – post-graduate student of the department of
Dermatovenerology of the I.I.Mechnikov Saint-Petersburg State Medical Academy.
Tel.: 8(921)747-30-85. E-mail: genasveta@rambler.ru
M a t e r i a l R e c e i v e d 10.06.2010 г.
1337 Слепнев+
UDC 613.014.24+615.07:615.454.12
© M.V. Slepnev, N.Yu. Frolova, 2010
Slepnev M.V., Frolova N.Yu. Study of pharmacological activity of ointments,
obtained on the basis of the gel Arespol // Preventive and clinical medicine. – 2010. № 2 (35). – Р.
Federal Agency of Health Care and Social Development State Educational
Institution of Higher Professional Educational «Saint-Petersburg State Chemical
Pharmaceutical Academy», Russia, 197376, St.-Petersburg, Popov str., 14, tel.:
8(812)234-57-29, fax: 8(812)234-60-44, е-mail: rector@spcpa.ru
Summary:
Characteristic anti-allergic and anti-inflammatory action of
the developed gels with 5% tannin; 5% zink oxide and 1% dimedrol; 5% zink oxide
and 2% novocaine was established on the experimental model of allergic contagious
dermatitis, which denotes the possibility of gel Arespol use in the compounding the
above formulations instead of traditionally employed vaseline.
Key
w o r d s : acrylic polymers; Arespola gel, extemporal ointments,
dermatitis
References
1. Алексеев К.В. Опыт использования редкосшитых акриловых полимеров
в составе новых дерматологических препаратов / К.В. Алексеев // Матер. науч.практ. конф. «Актуальные вопросы косметологии». – СПб., 2000. – 80 с.
2. Алексеев К.В. Редкосшитые акриловые полимеры в фармации /
К.В. Алексеев, В.Н. Ли, В.Н. Демишев // Фармация. - 1987. - № 5. - С. 15–18.
3. Залкан П.М. Влияние синтетических моющих средств на реактивность
кожи морских свинок / П.М. Залкан, Е.А. Иевлева // Актуальные вопросы
профессиональной дерматологии. – М.: Медицина, 1965. – 112 с.
83
4. Изучение возможности получения олеогелей с местными анестетиками
на основе редкосшитых акриловых полимеров / Б.Л. Молдавер [и др.]  Х
Российский национальный конгресс «Человек и лекарство»: тез. докл. – М.,
2003. - С. 636.
5. Тенцова А.И. Современные аспекты исследования и производства мазей
/ А.И. Тенцова, В.М. Грецкий. – М.: Медицина, 1980. – 192 с.
6. Formulating Topical Products // The proven polymers in pharmaceuticals.
Bulletin 14. – B.F. Goodrich, 1994.
7. Polymers for Pharmaceutical Applications // The proven polymers in
pharmaceuticals. Bulletin 1. – B.F. Goodrich, 1994.
Information about the authors:
Slepnev Michail Vladimirivich - candidate of pharmaceutical sciences,
assistant-professor of the Department of Technology of Medicinal Forms, SaintPetersburg State Chemical Pharmaceutical Academy, work tel.: 8(812)234-49-31, email: ILCKKLS@yandex.ru
Frolova Natalia Yuryevna - candidate of biological sciences, senior research
worker of the Laboratory of Pharmacological Studies, Saint-Petersburg State
Chemical
Pharmaceutical
Academy,
work
tel.:
8(812)234-90-34,
e-mail:
nyfrolova@mail.ru
M a t e r i a l R e c e i v e d 24.06.2010 г.
1344 Комлева
UDC 616.741:616.711:613.60
© N.E. Komleva, V.F. Spirin, T.V. Grishina, T.A. Novikova, V.A. Medentsov,
N.A. Mikhailova, V.O. Skvortsov, 2010
Komleva N.E, Spirin V.F, Grishina T.V, Novikova T.A, Medentsov V.A,
Mikhailova N.A, Skvortsov V.O Influence dorsopatiya of agricultural workers on
quality of life // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
Federal State Institution of Science Saratov Research Institute of Rural
Hygiene of the Federal Service for Supervision of Consumer Rights Protection and
Human
Welfare
(FSIS
Saratov
Research
Institute
of
Rural
Hygiene
84
Rospotrebnadzor). Russia, 410022, Saratov, str. Zarechnyа, 1a. Tel.: 8 (8452) 92-7890. E-mail: niisgsar@rol.ru
S u m m a r y : Quality of life of agricultural workers with a diagnosis
dorsopatiya statistically significantly lower compared to urban residents. Most likely,
such social components, as working conditions and peculiarities of life in rural areas
are important factors in the analysis of quality of life.
K e y w o r d s : dorsopatiya, quality of life, agricultural workers.
Список литературы
1. Болевые синдромы в неврологической практике / А.М. Вейн [и др.];
под ред. А.М. Вейна. - М.: Медпресс, 1999. – 372 с.
2. Григорьева В.Н. Психосоматические аспекты нейрореабилитации.
Хронические
боли
/
В.Н.
Григорьева
–
Нижний
Новгород:
Изд-во
Нижегородской гос. Медицинской академии, 2004. – 420 с.
3. Новик А.А. Руководство по исследованию качества жизни в медицине /
А.А. Новик, Т.И. Ионова. - СПб.: Издательский дом «Нева», 2002. - 320 с.
4. Bullinger M. Health has connected quality of life and subjective health. The
brief review of the status of a research for new criterions of an evaluation in medicine
/ M. Bullinger // Psychother.-Psychosom. Med. - 1997. - Vol. 47. - P. 76-91.
5. Meers C. Quality, connected by health, of life in clinical practice / C. Meers
// J. GANNT. – 1996. - Vol. 6. - P. 29-31.
6. Meier D. Evaluation of quality of life / D. Meier // Ther. Umsch. - 1997. Vol. 54. - P. 321-325.
7. Musschenga A.W. The relation between the concepts «Quality of life»,
health and good luck / A.W. Musschenga // J. Med. Philos. - 1997. - Vol. 22. - P. 1128.
8. Osoba D., Brada M. Health-related quality of life in pacients treated with
temozolomide vs. procarbazine for recurrent glioblastoma miltiforme / D. Osoba, M.
Brada // J. Clin. Oncol. - 2000. - V. 18. - № 7. - Р. 481-491.
9. Pincus T., Griffit J. Prevalence of the self-informed depression in the
patients with rheumatoid arthritis / T. Pincus, J. Griffit // Br. J. Reumatol. - 1996. 85
Vol. 35. - P. 879-883.
10. Staguet M.J. Quality of life assessment in clinical trials / M.J. Staguet. Oxford university Press: Oxford. New York, Tokyo. - 1998. - 360 p.
Information about the authors:
Komleva Natalia E. - PhD, Head of the Clinical Division FSIS Saratov Institute
of Rural Hygiene Rospotrebnadzor, work tel.: 8 (8452) 92-78-90, home tel.: 8 (8452)
23-05-86, mobile tel.: 8 - 917-217-07-67. E-mail: natkom@hotbox.ru
Spirin Vladimir F. - MD, professor, director of FSIS Saratov Institute of Rural
Hygiene Rospotrebnadzor, work tel.: 8 (8452) 92-78-90.
Grishina Tatiana V. - PhD, Senior Fellow of the clinical department FSIS
Saratov Institute of Rural Hygiene Rospotrebnadzor, work tel.: 8 (8452) 92-78-90.
Novikova Tamara A. - PhD, Head of the Department occupational medicine
FSIS Saratov Institute of Rural Hygiene Rospotrebnadzor.
Medentsov Vyacheslav A. - Junior Researcher of the clinical department FSIS
Saratov Institute of Rural Hygiene Rospotrebnadzor, work tel.: 8 (8452) 92-78-90.
Mikhailova Natalia A. - PhD, senior researcher at the Department of
Occupational Medicine FSIS Saratov Institute of Rural Hygiene Rospotrebnadzor,
work tel.: 8 (8452) 92-78-90.
Skvortsov, Vyacheslav O. - the clinic of occupational diseases FSIS Saratov
Institute of Rural Hygiene Rospotrebnadzor, work tel.: 8 (8452) 92-78-90.
M a t e r i a l R e c e i v e d 30.06.2010 г.
EPIDEMIOLOGY, DIAGNOSTICS, CLINIC AND PREVENTION OF
INFECTIOUS AND PARASITIC DISEASES
1346 Каргальцева+
UDC 616.1-07:616.9
© N.M. Kargaltseva, A.T. Burbello, V.I. Kocherovets, A.S. Fedorenko, 2010
Kargaltseva N.M.1, Burbello A.T.1, Kocherovets V.I.2, Fedorenko A.S.1 Clinical
and microbiological features of blood flow infections // Preventive and clinical
medicine. – 2010. - № 2 (35). – Р.
86
1
State Educational Establishment for Higher Professional Training «Saint-
Petersburg State Medical Academy named after I.I. Mechnikov of the Federal
Agency for Public Health and Social Development of the Russian Federation»,
Russia, 195067, St. Petersburg, Piskarevsky pr., 47, tel./fax: 8(812)543-01-26, email: mechnik@gmail.com
2
The I.M.Sechenov Moscow Medical Academy the State Education Institution
of Higher Professional Training of the Federal Agency of Health Care and Social
Development of the Russian Federation. Russia, 119991, Moscow, Trubetskaya
street, 8-2. Теl.: 8(495)248-05-53, e-mail: http://www.mma.ru
S u m m a r y : Bloodstream infection (BI) is connected with the presence of
both the microorganisms in blood and the clinical symptoms in patients. It is known
that high temperature is a leading clinical symptom of infectious disease. Obtained
hemoculture confirms the presence of microorganisms in blood. The authors
compared the clinical symptoms of bloodstream infection with the results of
microbiological blood tests. There were 204 patients interviewed according to a
special questionnaire. All patients, blood was analysed by microscopic and
cultivation tests. The leading clinical symptoms of patients with BI were: high
temperature and chill (63,2%), skin abscesses (72,1%), diseases of upper respiratory
tract (63,7%) and unstable stool (diarrhea or constipation) (53,9%). Blood was
collected in anticoagulant to have buffy-coat layer which was used for the blood
smears and blood culture.
The blood smears for microscopic examination were painted using Gram
method.
Blood cultures were kept in aerobic and anaerobic conditions. The
microorganisms
were
discovered
in
97,8%
of
the
blood
smears
as
monomorphologies (17,4%) and associations of morphological forms (82,6%). The
microorganisms were isolated in 55,2% of blood samples as monomorphologies
(64,3%) and associations of morphological forms (35,7%).
It was revealed logical connection between certain clinical manifestations of
bloodstream infection and the presence of various microorganisms in blood by
87
detecting the clinically important symptoms of bloodstream infection along with
discovering and isolating blood microorganisms by rapid and express methods.
K e y w o r d s : clinical symptoms; blood smear; hemoculture; buffy coat.
References
1. Дисбактериозы – актуальная проблема медицины / А.А. Воробьев,
Н.А. Абрамов, В.М. Бондаренко, Б.А. Шендеров // Вестн. РАМН. - 1997. № 3. - С. 4-7.
2. Пат.
2098486
Н.М. Каргальцева;
РФ.
заявитель
Способ
и
диагностики
патентообладатель
бактериемии
/
Санкт-Петербургская
государственная медицинская академия им. И.И. Мечникова. - № 95\10928\13
от 21.06.95, Бюл. № 34. – 5 с.
3. Принципы
бактериологического
исследования
крови
больных
инфекционным эндокардитом. Методические рекомендации / В.И. Кочеровец,
Н.М. Каргальцева, В.С. Гуревич, Б.Б. Бондаренко. - Ленинград, 1990. – 23 с.
4. Beekmann S.E. Determining the clinical significance of coagulase-negative
Staphylococci isolated from blood cultures / S.E. Beekmann, D.J. Diekema,
G.V. Doern // Infect. Control. Hosp. Epidemiol. - 2005. - Vol. 26. № 6. - P. 559-566.
5. Fever in liver transplant recipient: changing spectrum of etiologic agents /
F.Y. Chang, N. Singh, T. Gayowski, M.M. Wagener, J.R. Marino // Cl. Inf. Dis. 1998. - Vol. 26. - P. 59-65.
6. Nosocomial bacteremia: clinical significance of a single bloodculture
positive for coagulase-negative staphylococci / B. Favre, S. Hugonnet, L. Correa,
H. Sax, P. Rohner, D. Pittet // Infect. Control. Hosp. Epidemiol. - 2005. - Vol. 26.№ 8. - P. 697-702.
Information about the authors:
Kargaltseva Nataliya Mikhailovna c- Candidate of Medical Sciences, teacher at
the course of clinical laboratory diagnostics of the Mechnikov Saint-Petersburg State
Medical Academy. Work tel.; 8(812)292-32-25, e-mail: kargaltseva@nail.ru
Burbello Aleksandra Timofeevna – Doctor of Medicine, Professor of the
department of Hospital Therapy with the course of Clinical Pharmacology, Family
88
Medicine and Clinical Laboratory Diagnostics; head of the course of Clinical
Pharmacology of the Mechnikov Saint-Petersburg State Medical Academy. Work
tel.: 8(812)543-94-34, e-mail: at-burbello@yandex.ru
Kocherovets Vladimir Ivanovich – Doctor of Medicine, Professor of the
department of Pharmacological Chemistry and Pharmacognostics of the faculty for
Post-Diploma Professional Training (FPDPT) of the Sechenov Moscow Medical
Academy. Work tel.; 8(495)656-25-75
Fedorenko Anastasiya Mikhailovna – post-graduate student of the department
of Hospital Therapy with the course of Clinical Pharmacology and Clinical
Laboratory Diagnostics of the Mechnikov Saint-Petersburg State Medical Academy
M a t e r i a l R e c e i v e d 06.07.2010 г.
1312 Александрова+
UDC [616.314.17.18-008.1-06:616-002.5]:085.37(045)
© E.A. Aleksandrova, A.V. Lepilin, N.E. Kazimirova, A.A. Shuldyakov, 2010
Aleksandrova E.A., Lepilin A.V., Kazimirova N.E., Shuldyakov A.A. Cycloferon
liniment efficiency study in the complex therapy of oral cavity inflammatory diseases
in tuberculous patients // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
Saratov State Medical University named after V.I. Razumovsky, Russia,
410012, Saratov, Bolshaya Kazachya str., 112, tel.: 8(452)27-33-70, 8(452)51-15-32
fax:
8(452)51-15-34,
8(452)51-16-17,
Е-mail:
meduniv@sgmu.ru,
http://www.sgmu.ru
S u m m a r y : For the purpose to determine the clinic-pathogenetic efficacy
of Cycloferon liniment in the combined therapy of periodontitis of patients with focal
tuberculosis medical examination and treatment of 40 patients is carried out.
It is established, that use of liniment Cycloferon in the combined treatment of
patients with focal tuberculosis allows to accelerate process of normalization of
parameters lipid peroxidation and antioxidant potential of blood, to decrease infection
load (herpes symplex virus I, candida albicans, staphylococcus aureus) in parodontal
recess and evidence of local inflammation with reduction of activity of the factor
89
tumours necrosis and interleukin 1b, what provides acceleration of recuperation
processes, lowering of frequency of parodontitis backsets.
K e y w o r d s : periodontitis; tuberculosis; Cycloferon.
References
1. Васильева Л.С. Клинические варианты течения туберкулеза легких как
проявление адаптационных реакций организма в условиях
различных
эпидемиологических периодов / Л.С. Васильева, Т.П. Филиппова // Сибирский
медицинский журнал. - 2006. - № 6. – С. 35-41.
2. Данилевский
Н.Ф.
Заболевания
пародонта
/
Н.Ф. Данилевский,
А.В. Борисенко. - Киев: Здоровье, 2000. - 464 с.
3. Зайцева Е.М. Клинико-микробиологические параллели и цитокиновый
профиль
у
больных
пародонтитом
на
фоне
коплексного
лечения
с
использованием линимента циклоферона / Е.М. Зайцева // Автореф. дис. …
канд. мед. наук. – Волгоград, 2007. – 25 с.
4. Использование циклоферона и интерферона человеческого гамма препарата ингарон в комплексном лечении больных туберкулезом легких и
ВИЧ-инфекций / И. Йола [и др.] // Вестник СПбГМА им. И.И. Мечникова. 2006. - № 3. - С. 150-154.
5. Курякина Н.В. Заболевания пародонта / Н.В. Курякина, Т.Ф. Кутепова.
- Н.Новгород, 2000. – 158 с.
6. Романцов
М.Г.
Иммунодефицитные
состояния:
коррекция
циклофероном / М.Г. Романцов, Ф.И. Ершов, А.Л. Коваленко. – СПб. – 1998. –
35 с.
7. Соболева Л.А. Оптимизация терапии больных пародонтитом /
Л.А. Соболева, А.В. Лепилин, А.А. Шульдяков // Вестник Санкт-Петербургской
государственной медицинской академии им. И.И. Мечникова. – 2004. - № 1. С. 130-133.
8. Шилова М.В. Туберкулез в России / М.В. Шилова. - Воронеж: ВГПУ,
2007. – 150 с.
Information about the authors:
90
Aleksandrova Helen Aleksandrovna - the stomatologist of the therapeutic
department of № 1 consultative stomatological polyclinic on the profit and loss
accounting
basis
of
clinical
hospital
n.a. S.R. Mirotvortseva,
e-mail:
aleksandrova1970@mail.ru
Lepilin Alexander Victorovich - doctor of medicine, professor, head of
department
of
surgical
stomatology,
Saratov
State
Medical
University
n.a. V.I. Razumovsky, tel.: 8(8452)28-88-30.
Kazimirova Natalia Evgenyevna - doctor of medicine, professor, head of
department
of
Phtisiopneumology
Saratov
State
Medical
University
n.a. V.I. Razumovsky, phone: 8(8452)46-12-11; e-mail: kazimiroffv@inbox.ru
Shuldyakov Andrey Anatolyevich - doctor of medicine, professor, head of
department
of
infectious
disease,
Saratov
State
Medical
University
n.a. V.I. Razumovsky, phone: 8(8452)58-06-49, e-mail: Shuldaykov@mail.ru
M a t e r i a l R e c e i v e d 14.04.2010 г.
1284 Халикова+
UDC 616.36-002.14+546.172.6.31+612.11
© Sh.A. Khalikova, M.N. Daminova, 2010
Khalikova Sh.A., Daminova M.N. Amino acid spectrum and nitrogen oxide
state in blood serum of children with chronic virus hepatitis C // Preventive and
clinical medicine. – 2010. - № 2 (35). – Р.
Tashkent Pediatric Medical Institute of the Ministry of Health of the Republic
of Uzbekistan, Tashkent, Bagishomol str., 223. Tel.: 8(371)260-31-26, fax:
8(371)262-33-14, E-mail: tashpmi@rambler.ru
S u m m a r y : Studies have shown that patients with HCV amino acid
spectrum and the end products of nitric oxide (NO) in serum differ significantly
depending on the severity of the disease. So reliable elevation of argenin and NO
content in blood serum of patients may have a great importance in pathogenesis and
severity course of acute and chronic viral hepatitis C.
K e y w o r d s : hepatitis C, the spectrum of amino acids, nitric oxide.
91
References
1. Абдукадырова М.А. Прогностические маркеры хронизации вирусного
гепатита С / М.А. Абдукадырова // Иммунология. – 2002. – Т. 234.- № 1 – С. 4750.
2. Виноградов Н.А. Изменение синтеза оксида азота, содержания
адренокортикотропного гормона и кортизола в крови при вирусном гепатите В
/ Н.А. Виноградов // Клиническая медицина. – 2001. – № 11. – С. 47-51.
3. Ивашкин В.Т. Оксид азота в регуляции функциональной активности
физиологических систем / В.Т. Ивашкин, О.М. Дранкина // Российский журнал
гастроэнтерологии, гепатологии, колопроктологии. – 2000. – № 4. – С. 16-21.
4. Рома М.Я. Модификация экспресс-метода определения нитритов /
М.Я. Рома, Е.С. Яковлева, Я. Лутсо // Вопросы онкологии. – 1991. – Т. 37. –
№ 4. – С. 71-72.
5. Cooper C. Nitric oxide and iron proteins / C. Cooper // Biochim. Biophys.
Acta. – 1999. - Vol. 1411. – P. 290-309.
6. Debier C. Vitamins A and E: metabolism, roles and transfer to off spring /
C. Debier, Y. Larondelle // Br. J.Nutr. – 2005. – Vol. 93, № 2. – P. 153-174.
7. Stеven A. Amino Acid Analysis Utilizing. Fhenylisotiocyanata Derivatives /
A. Stеven, J. Cohen Daviel // Analyt. Biohem. – 1998. – Vol. 17, № 1. – P. 1-16.
Information about the authors:
Khalikova Shakhista Abdurakhmanbekovna - assistant of childhood infections
of the Tashkent Pediatric Medical Institute, Ministry of Health of the Republic of
Uzbekistan, Tashkent, Tel.: 8(371)245-38-08, fax: 8(371)262-33-14, E-mail:
tashpmi@rambler.ru
Daminova Malikа Nasirovna - MD, assistant professor of pediatric infections
of the Tashkent Pediatric Medical Institute, Ministry of Health of the Republic of
Uzbekistan, Tashkent, Tel.: 8(371)248-06-61, fax: 8(371)262-33-14, E-mail:
tashpmi@rambler.ru
M a t e r i a l R e c e i v e d 14.01.2010 г.
92
RESTORATIVE MEDICINE
1330 Бурмистров+
UDC 616.711.6-003.974:615.82
© D.A. Burmistrov, G.S. Demin, O.I. Khardikov, 2010
Burmistrov D.A.1, Demin G.S.2, Khardikov O.I.3 Strong training by STEN
method as a way to restore flexibility and reduce pain syndrome in patients with
lumbosacral osteochondrosis in different ages // Preventive and clinical medicine. –
2010. - № 2 (35). – Р.
1
St. Petersburg Institute of Bioregulation and Gerontology of the North-
Western Branch of the Russian Academy of Medical Sciences Federal State. Russia,
197110, St. Petersburg, Dinamo str., 3. Тel.: 8(812)274-56-50, fax: 8(812)717-25-50,
8(812)274-92-27. E-mail: ibg@gerontology.ru
2
«GENE», Ltd. Russia, 190020, St.-Petersburg, Tsiolkovsky str., 11. Тel.:
8(812)575-18-67, fax: 8(812)600-77-54. Е-mail: gene@alkorbio.ru
3
St. Petersburg State Medical Academy named after I.I. Mechnikov. Russia,
195067, St. Petersburg, Piskarevsky pr., 47, tel./fax: 8(812)543-01-26, e-mail:
mechnik@gmail.com
Summary:
The program STAN promotes an increase of strength
qualities, recovery of flexibility, elimination of pain syndrome and increase of
physical capacity. Using this program allows the person to carry out whole amount of
different activities, improving quality of life.
Key
words:
spinal osteochondrosis; pain syndrome; power training;
flexibility; quality of life.
References
1. Бубновский С.М. Руководство по кинезитерапии дорсопатий и грыж
позвоночника / С.М. Бубновский. – М.: «МАКС Пресс», 2002. – 100 с.
2. Бурмистров Д.А. Силовая тренировка при болевом синдроме в спине:
Учебно-методическое пособие / Д.А. Бурмистров, В.С. Степанов. – СПб.:
СПбГАФК им. П.Ф. Лесгафта, 2003. – 63 с.
93
3. Гупта М.К. 69 уникальных лечебных поз и упражнений от болей в
позвоночнике, спине и шее: Естественный путь к здоровью / М.К. Гупта. – М.:
АСТ: Астрель, 2007. – 127 с.
4. Ингерлейб М.Б. Анатомия Физических упражнений / М.Б. Ингерлейб. –
Ростов н/Д: Феникс, 2009. – 187 с.
5. Милюкова И.В. Оздоровительная гимнастика для позвоночника /
И.В. Милюкова, Т.А. Евдокимова. – М.: АСТ; СПб.: Сова, 2007. – 156 с.
6. Попелянский А.Я. Клиническая пропедевтика мануальной медицины /
А.Я. Попелянский. – М.: МЕДпресс-информ, 2003. – 136 с.
7. Laliberte R. The men's health guide to peak conditioning / R. Laliberte,
S.C. George. – USA: Rodale Inc, 1997. – 384 p.
8. Sandler D. Weight training fundamentals / D. Sandler. – USA: Human
Kinetics Publishers, 2003. – 152 p.
9. SF-36 Health Survey: Manual and interpretation guide / J.E. Ware,
K.K. Snow, M. Kosinski, B. Gandek. – Boston: The Health Institute, New England
Medical Center, Mass, 1993. – 126 p.
10. Vella M. Anatomy for strength and fitness training / M. Vella. – London:
New Holland Publishers (UK) Ltd, 2006. – 144 p.
Information about the authors:
Burmistrov Dmitrii A. - Ph.D., Senior Researcher, Laboratory of Clinical
Pathology age of the St. Petersburg Institute of Bioregulation and Gerontology of the
North-Western Branch of the Russian Academy of Medical Sciences, Saint
Petersburg, Russia, tel.: 8(812)274-92-27. E-mail: bur350@yandex.ru
Demin G.S - Ph.D., director of development NIKOR, Gene Ltd, Saint
Petersburg, Russia. E-mail: gregdemin@gmail.com
Khardikov Oleg I. – clinical ordinator of the Department of Neurology,
Neurosurgery and Medical Genetics of
named
after
I.I.
Mechnikov.
St. Petersburg State Medical Academy
Work
tel.:
8(812)543-01-26,
e-mail:
malegic1@yandex.ru
M a t e r i a l R e c e i v e d 08.06.2010 г.
94
1335 Гзогян+
UDC 616.127-005.8-08-039.34:615.825
 M.N. Gzogyan, N.I. Tarasov, L.K. Isakov, D.S. Krivonosov, T.V. Kuznetsova,
A.P. Yarkovskaya, A.T. Teplyakov, 2010
M.N.1,
Gzogyan
Kuznetsova T.V.1,
Tarasov N.I.1,
Yarkovskaya A.P.1,
Isakov L.K.1,
Teplyakov A.T.2
The
Krivonosov D.S.1,
effectiveness
of
rehabilitation measures with long-standing physical training in outpatient recovery in
patients after myocardial infarction // Preventive and clinical medicine. – 2010. - № 2
(35). – Р.
1
State educational institution of higher professional education «Kemerovo State
Medical Academy», Federal Agency for Health and Social Development, Faculty of
postgraduate training. Russia, 650029, Kemerovo, Voroshilova str., 22-a. Тel:
8(3842)73-48-56, e-mail: kemsma@kemsma.ru
2
State institution Scientific-Research Institute of Cardiology of the Tomsk
scientific center of Siberia filial of the Russian Academy of Medical Sciences (SI
SRIC TSCSF RAMS), Russia, 634012, Tomsk, Kievskaya str., 111-a, tel.:
8(3822)55-54-04, fax: 8(3822)55-50-57, e-mail: administration@cardio.tsp.ru
S u m m a r y : In the outpatient rehabilitation of patients, MI constant
controlled physical training run on the background of the supporting base ischemic
therapy are highly effective and safe: significantly reduced the frequency weight,
angina and FC; increase exercise tolerance and quality of life.
Key
w o r d s : rehabilitation; myocardial infarction; controlled physical
training; outpatient.
References
1. Аронов
Д.М.
Постстационарный
этап
реабилитации
больных
ишемической болезнью сердца / Д.М. Аронов, М.Г. Бубнова, Г.В. Погосова //
Сердце. – Т. 4, № 2. - С. 103-107.
2. Гасилин В.С. Поликлинический этап реабилитации больных инфарктом
миокарда / В.С. Гасилин, Н.М. Куликова. - М.: Медицина, 1984. – 176 с.
95
3. Николаева Л.Ф. Реабилитация больных ишемической болезнью сердца
/ Л.Ф. Николаева, Д.М. Аронов. - М.: Медицина, 1988. – 288 с.
4. Статико–динамические тренировки в стационарной реабилитации
больных с острой коронарной патологией / А.Н. Сумин [и др.] // Кардиология. –
2000. - № 3. – С. 16–21.
5. Тарасов Н.И. Значение ранних нагрузочных тестов для прогноза и
сроков
госпитализации
больных
инфарктом
миокарда
/
Н.И. Тарасов,
О.Л. Барбараш, В.Н. Каретникова // Российский кардиологический журнал. –
1998. - № 1. – С. 3 – 10.
6. Чернявская Т.К. Изучение эффективности и безопасности применения
дозированных физических тренировок в комплексной терапии пациентов с
ХСН III-IV ФК / Т.К. Чернявская, О.Н. Волгина // Журнал Сердечная
недостаточность. – Т. 5, № 5. - С. 244-248.
7. Aronow W.S. Effect of beta blockers alone, of angiotensin - converting
enzyme inhibitors alone, and of beta blockers plus angiotensin - converting enzyme
inhibitors on new coronary events and on congestive heart failure in older persons
with healed myocardial infarcts and asymptomatic left ventricular systolic
dysfunction / W.S. Aronow, C. Ahn, I. Kronzon // Am J Cardiol. - 2001.- Vol. 88,
Issue 11. - P. 1298-1300.
8. Effects of short-term exercise training and activity restriction on functional
capacity in patients with severe chronic congestive heart failure / K. Meyer [et al.] //
Am. J. Cardiol. – 1996. - Vol. 78. - P. 1017-1022.
9. Prognostic significance of myocardial ischemia detected by ambulatory
electrocardiography, exercise treadmill testing, and electrocardiogram at rest to
predict cardiac events by one year (The Asymptomatic Cardiac Ischemia Pilot
[ACIP] Study / P.H. Stone [et al.] // Am. J. Cardiol. - 1997. - Vol. 80. - P. 1395-1401.
10. Combination neurohormonal blocade with ACE inhibitors, angiotensin 2
antagonists and beta-blockers in patients with heart failure / R. Tsuyuki [et al.] // Can
J Cardiol. - 1997. - Vol. 13. - P. 1166-1174.
Information about the authors:
96
Gzogyan Margarita Nikolaevna - PhD, Assistant Professor Department of
doctors in primary care and SMP GOU VPO KemGMA Federal Agency for Health
and Social Development, a phone: 8(3842)32-72-86, e-mail: MargoV@inbox.ru
Tarasov Nikolai Ivanovich - Doctor of Medical Sciences, Professor, Head of
the Department of doctors in primary care and SMP GOU VPO KemGMA Federal
Agency for Health and Social Development, the phone: 8(3842)64-45-98, e-mail:
tarassov@kuzbass.net
Isakov Leonid Konstantinovich - PhD, Assistant Department of doctors
primary health care and SMP GOU VPO KemGMA Federal Agency for Health and
Social Development, the phone: 8(3842)32-72-86, e-mail: isakovy @ inbox.ru
Krivonosov Denis Sergeevich - PhD, Assistant Department of doctors in
primary care and SMP GOU VPO KemGMA Federal Agency for Health and Social
Development, a phone: 8(3842)32-72-86, e-mail: cardden@mail.ru
Kuznetsova Tatyana Vasilevna - graduate student education of doctors in
primary care and SMP GOU VPO KemGMA Federal Agency Health and Social
Development, phone: 8(3842)32-72-86, e-mail: doccard-ktv@mail.ru
Yarkovskaya Alena Pavlovna - graduate student education of doctors in
primary care and SMP GOU VPO KemGMA Federal Agency Health and Social
Development, рhone: 8(3842)32-72-86, e-mail: alena-ya@mail.ru
Teplyakov Alexander Trofimovich - Doctor of Medical Sciences, professor,
head of cardiac insufficiency GU NIIK TNC RAMN, phone: 8(3822)55-54-04, email: administration@cardio.tsu.ru
M a t e r i a l R e c e i v e d 11.06.2010 г.
MEDICAL PSYCHOLOGY, PSYCHIATRY, PSYCHOTHERAPY
1277 Белов+
UDC 616.895.6
© V.G. Belov, Yu.A. Parfеonov, A.V. Dergunov, M.S. Orlovsky, 2010
97
Belov V.G., Parfenov Yu.A., Dergunov A.A., Orlovsky M.S. Art therapy in
treatment of non-psychotic affective distresses // Preventive and clinical medicine. –
2010. - № 2 (35). – Р.
Federal State Institution «Military Medical Academy named after S.M.Kirov of
the Ministry of Defense of the Russian Federation», Russia, 194044, St.-Petersburg,
Aс. Lebedev str., 41. Тel.: 8 (812) 292-32-23, fax: 8 (812) 745-65-19. Е-mail: myinternet@mail.ru
S u m m a r y : Presented data on examination to evaluate psychotherapeutic
effectiveness of the art-therapy method for patients with depressive conditions of
non-psychotic range, coupled with somatic pathology of a different degree and
psychopathologic structure.
Key
w o r d s : art-therapy; affective disorder; psychotherapy; somatic
depression.
At the present time long-period somatical (latent depressive) depressions, being
so-called “challenge for psychiatry and psychology” remain the object for continuous
discussions, and their treatment remains one of the most important problems for the
domestic and foreign psychiatry [1–4].
The great interest of the researchers to this problem appears not only due to vast
distributions of these depressive conditions (up to 30% – 35%) [5] and high level of
psychosocial disorders in patients with chronic somatical depressions but also
preconditioned by difficulty and unclear status of numerous doubtful questions on
their correction and prophylactics.
Despite the presence of multiple elaborated plans for farmacotherapy there is no
univocal opinion for the action of biological therapy on clinical appearances of different
symptoms at somatical depressions [5,6].
That’s why there is obvious the necessity of extension of the therapeutic means
for correction the somatical depressions by non-biologic therapy - the psychotherapy.
In this presented examination, the means of correction the affective pathology is
used the method of art-therapy, which combines the medical and humanitarian
knowledge and helps forward increased effectiveness of therapy.
98
The
purpose
of
this
w o r k . To investigate the dynamics of
somatical affective disorders in patients, who underwent art-therapy at exacerbation and
remission periods.
Material
and
m e t o d s . At the methodical point of view this
investigation was planned as an opened application of art-therapy for treatment of
somatical depression.
There were selected the next criteria for inclusion of patients into the trial:
1. Male and female patients aged from 18 to 65 years old.
2. The accordance with diagnostic criteria of International Classification of
Diseases (10-th edition) for various types of somatical depressions.
3. Rating of depression on the Hamilton’s scale (HDRS) [7].
The examination was performed as the monopsychotherapy method. There was
provided the wash-out period at which all the psychotropic drugs were avoided for
patients not less than 48 hours prior the basal psychiatric and neurological evaluation
of the patient’s status. In a case of acute excitement or severe insomnia there was
allowed the application of benzodiazepine drugs. Psychotherapy course for all the
patients was 12 weeks.
The choice of topics and techniques of art-therapy is defined on the estimation
of the necessities of the group and general tasks for correction and prophylactics of
affective prepsychotic disorders. The process of the group art-therapy included three
main stages: (1) the stage of basal diagnostics and formation of therapeutic and group
relations; (2) main stage, directed to reconstruction of personality and harmonization
of the patient’s system of relations; (3) Final stage (Table 1) [8].
Table 1
Characteristics of the group art-therapy for correction of affective disorders in examined
sample group
Stages
1 Stage
2 Stage
Purposes of the stage
Preliminary interview and preparation of patients for taking part in the group work,
evaluation of anamnesis and concomitant diseases, formation of intent for atrtherapeutic treatment; beginning of work with the group, acquaintance of the group
members.
Psychological self-revelation of the members of the group (individual needs, feelings
and problems) in creative activity and discussions; processing of internal personal
99
3 Stage
conflicts, changes of self-overview in patients about themselves and others, getting of a
new experience and new skills by patients.
Summarizing the results of the group work, fixation of the acquired experience and
skills and also planning by the group members the exact steps on application the
acquired experience in their every day’s life
For objectifications of the clinical data there was provided the secondary
application of the psychometric scale HDRS. The evaluation was performed on
different stages of treatment: before the course of art-therapy there was estimated the
basal condition of patient (first control point), in 4 weeks from the beginning of
therapy there was registered the primary effect (second control point); and the final
estimation was performed after 12 weeks at the end of investigation (third control
point). The criteria of the good therapeutic effect was considered the reduced rating
on the HDRS scale more than 30%. These patients were the group of responders.
Other patients were the group of non-responders.
In our investigation there were included 29 patients (15 women and 14 men),
who underwent the treatment in a day-time hospital of the psycho-neurological
dispensary №6, St.Petersburg. All the patients were appropriate to criteria of the
International Classification of Diseases (10-th edition) for the part of somatoformical
disorders (somatical depressions) (Table 2). The mean age was 31,4±6,8 years old.
The anamnesis of the disease was from 5 months to 16 years, mean length of the
disease was 3.9 years. The mean value on the Hamilton’s scale on the moment of
inclusion for investigation was 17,2±1,9 what indicates a moderate level of
depression in examined patients.
Table 2
Psychical disorders in a sample group
Amount of cases
Exact disease
6 cases
Vegetative depression [1]
2 cases
Apatical depression
10 cases
somatic depressive (somatical) dystimia
11 cases
Vital cyclotimic depression
100
Analysis
of
e f f e c t i v e n e s s . All 28 patients had finished
investigation and were included to analysis of the effectiveness. There were no cases
of refuse from psychotherapy and impossibility to perform art-therapy due to
cancellation of biological therapy or other reasons.
When we used the sign of reduction for summary rating Hamilton’s scale, at
the end of course of therapy in all the group of patients, who underwent art-therapu
there were subdivided two groups: 16 (55%) patients were included in group №1 responders and 13 (45%) patients in group №2 - non-responders.
Reduce of rating on the HDRS scale during the process of therapy prevealed in
responders group with presence of anxious-depressive symptoms in the structure of
the actual exacerbation. This parameter at the final testing in the group №1 was 2.8
(Pic. 2)
In a clinical pattern in non-responders group there prevailed such symptoms as
a bad mood with feelings of a vital angst, anhedonical complaints, loss of ability to
work, insomnia with early wakening, feelings of internal exertion and
unclear
anxiety.
The same as in responders group, these patients already on the first week
demonstrated the significant reduce of anxiety, but it’s basal level in this group was a
bit lower - 3,56±1,3, but after the anxiety symptoms increased and at the end of
HDRS rating
investigation were 3.2±1,1 (Pic. 1).
6
5,5
5
4,5
4
3,5
3
2,5
2
Group 1
1-st control
point
2-тв control
point
3-rd control
point
Group 2
Picture 1. Dynamics of the anxiety rating on HDRS scale during art-therapy in responders group
There was markable that at initial investigation the expression of
psychopathological symptomatics in first group was a little bit more than in a second
101
group, but there were no statistical difference between them (р>0,05). So, the general
expression of psychopathologic signs was not determinative in sensitivity to arttherapy.
Already after 4 weeks there was marked the trend to more effective art-therapy
in a group of patients with depressive symptoms. On the first stage of therapy the
statistically obvious differences were registered by subscales, characterizing the
anxiety-depression and somatical disorders (Pic. 2).
After reducing of the anxiety rating other symptoms of depression also reduced
smoothly, quite quickly (up to 2-nd – 3-rd week of treatment) disappeared insomnia
and patients became more active physically, their mood had evened, but their
complaints on anhedonia remained as well as reduced ability to work, problems with
mental concentration, general somatical disbalance, disorders of the sexual mood and
the weight loss. These symptoms appeared to be more resistant to conducted therapy
and reduced only at the 4-6-th week of therapy – the patients started making real
plans for future and more optimistically estimated their perspectives and started
taking part in the everyday’s life and family activity. The indexes of positive
dynamics in reduction of rating in Hamilton’s scale demonstrate the statistically
reliable (p<0,001) reduce of depressive expressions (Table 3).
102
Suicide tends
Guilt feelings
Bad mood
Disorders of sexual mood
General somatical disorders
Gastrointestinal disorders
Somatic angst
Excitation
Restraint
Work and activity
Early waking
Insomnia
Difficult dormition
Suicide tends
Guilt feelings
Bad
mood4 weeks of art-therapy on HDRS subscales
re 2. Reduce of rating
during
Group 2
Group 1
Pictu
On the basis of presented
data0,5there is1possible1,5to make2 a proposition
that
0
2,5
3 so
quick reduction of somatical symptoms is due to registration mostly secondary
symptoms (conditioned by anxiety) which depend on expression of depressive
disorders.
Reduction of depressive symptoms in non-responders group appeared to be
slower, although their initial rating on Hamilton’s scale was higher than in responders
- 18,1±1,9. To the end of investigation the reduction of depressive symptoms in this
group was 62,4% from initial level and the mean range on Hamilton;s scale was
11,3±1,5 (Table 3).
Table 3
Results of indexes on HDRS method in longitude
Control point №
1
2
3
1 group
m±n
17,8±2,9
12,3±1,2
7,5±0.8
2 group
m±n
18,1±1,9
14,2±1,4
11,3±1.5
р
>0,05
>0,05
<0,05
103
The results of mathematical analysis, calculation of mean numbers, standard
deviation and standard fallibility of mean number using Student’s t-criteria, the
reliable differences in groups were achieved in the third control point.
Results
1. The main direction of the therapeutic method is anxiolytical activity, what is
proved by a high level of anxiety reduction in responders and non-responders group.
2. Art-therapy has significant therapeutic ability for moderate depressive
disorders, especially those, where main component of depressive syndrome is an
anxiety combined with somatical appearances.
3. There is important to notice that among patients with recurrent affective
disorders there were included to responders group mostly patients with a light degree
of affective disorders, whereas in non-responders group there were mostly those with
moderate degree of depressive disorder. There was insufficient effectiveness of the
method for vital signs of depression at sufficient anxyolitic effect in these patients,
what makes a task of combination the art-therapeutic method and anxyolitic means.
4.
The results of the present investigation allow to make the conclusion on
effectiveness of art-therapy for treatment a moderate deprerssive symptomatics,
combined with psychosomatic reactions and vegetative disfunctions as the nonpsychotic depressive disorders.
References
1. Авруцкий Г.Я. Лечение психически больных / Г.Я. Авруцкий, А.А.
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6. Морозова М.А. Психиатр. и психофармакотер / М.А. Морозова, А.Г.
Бениашвили, Н.Б. Жаркова // Вестн. ВМедА им. С.М. Кирова. – 2008. – № 1. –
С. 74–75.
7. Морозова М.И. Британская модель оказания арт-терапевтической
помощи» / М.И. Морозова, А.И. Кобиясов, В.Б. Жарикова // Вестн. ВМедА им.
С.М. Кирова. – 2008. – № 1. – С. 74–75.
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Information about the authors:
Belov Vasiliy Georgievich - Doctor of medical science, professor of the subfaculty of health psychology of Saint-Petersburg State Institute of Psychology and
Social Work, 13-a, 12th line B.I., Saint-Petersburg,199178, tel.: 8(921) 400-16-47.
Parfеonov Yuriy Alexandrovich - Candidate of medical science, scientific
associate of the research laboratory of clinical pathophysiology of the sub-faculty of
pathological physiology of the Military Medical Academy named after S.M.Kirov,
tel.: 8(921)400-16-43.
Dergunov Andreiy Anatolievich - Candidate of medical science, scientific
associate of the research laboratory of clinical pathophysiology of the sub-faculty of
pathological physiology of the Military Medical Academy named after S.M.Kirov,
tel.: 8(921)400-16-43.
Orlovsky Mikchail Sergeevich - psychiatrist of psychoneurologic dispencary
No.6 of Kolpinskiy district, Saint-Petersburg. 1/5, Lenina prospect, Kolpino, SaintPetersburg, 196563, tel.: 8(952)204-89-03.
M a t e r i a l R e c e i v e d 22.12.2009 г.
1282 Власова +
UDC 616. 12—008.331. 1:615.851. 13
© O.L. Vlasova, 2010
105
Vlasova O.L. Clinico-psychological features of patients with a various clinical
versions of current of a metabolic syndrome // Preventive and clinical medicine. –
2010. – № 1 (35). – Р.
Smolensk State Medical Academy, Russia, Smolensk, 214000, Krupskay str.,
28, tel.: 8(4812)61-08-47; e-mail: sgma.info.ru
S u m m a r y : Dynamic inspection of 60 patients with arterial hypertension
within the limits of metabolic syndrome in the age of from 35 till 65 years (middle
age 47,8±1,1 years) by which besides clinical, laboratory-tool inspection it was spent
psychosommatic testing for a background of reception combined antihypertensive
therapies is lead: candesartan and hydrochlorothiazide. It is shown, that as a result of
treatment at patients it was observed proof hypothensive effect, there was a tendency
to improvement of parameters lipidograme, has raised complaens to treatment, and
the main thing, parameters of jet and personal uneasiness have authentically
decreased, parameters of a physical, mental condition and, as a whole, the general
quality of a life of patients have improved.
Key
words:
аrterial
hypertension
and
metabolic
syndrome;
psychosommatic testing; candesartan and hydrochlorothiazide; lipidograme; quality
of a life.
References
1. Баженова М.И. Приоритетные направления психологической работы с
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5. Сыркин Ф.Л., Копылов Ф.Ю., Дробижев М.Ю. и др. Клинические и
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хронического стресса // Клиническая медицина. – 2008. - № 2. – С. 6-23.
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клуб, 2000. – 259 с.
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Е.И.,
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Погосова
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и
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Клинико-
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практике: у больных артериальной гипертонией и ишемической болезнью
сердца (КООРДИНАТА): первые результаты многоцентрового исследования //
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Information about the author:
Vlasova Oksana Leonidovna - Department of Pediatrics, therapy and dental
schools Smolensk State Medical Academy, tel.: 8(4812)32-20-53. E-mail:
odinets1974@rambler.ru
M a t e r i a l R e c e i v e d 29.12.2009 г.
SCIENTIFIC REVIEWS
1290 Романцов +
UDC 615.28-053.2/.6
© M.G. Romantsov, L.G.Goryacheva, A.L.Kovalenko, 2010
107
Romantsov M.G.1, Goryacheva L.G.2, Kovalenko A.L.3 Pharmaco-therapeutic
cycloferon efficacy in pediatric practice // Preventive and clinical medicine. – 2010. № 2 (35). – Р.
1
Saint-Petersburg state medical academy named after I. I. Mechnikov, Saint-
Petersburg, Russia, 195067, Saint-Petersburg, Piskariovsky pr. 47, Tel.: 8(812)54513-39, fax: 8(812)545-13-39. E-mail: mechnik@gmail.com
2
Federal State Institution “Research Institute for Children Infections” of the
Federal medical-and-biological agency (FSI RICI FMBA Russia). Russia, 197022,
Saint-Petersburg, Professor Popov str., 9. Tel.: 8(812)234-96-61. E-mail:
niidi@niidi.ru
3
Scientific-Technological Pharmaceutical Firm «POLYSAN», Russia, 191119,
Saint-Petersburg, Ligovsky prospect, 112, tel.: 8(812)110-82-25,112-13-79. E-mail:
sales@polysan.ru, STPF «POLYSAN», www.polysan.ru
S u m m a r y : The article presents the authors and literary data on cycloferon
pharmacotherapeutic efficiency – the drug belonging to the group of interferon
inductors, immunomodulators. Cycloferon effect in treatment of different socially
important children diseases, including acute respiratory viral infections, bronchial
asthma, allergic states, accompanied by the disorders of anti-infectious protection,
mycoplasmic infection, broncho-pulmonary complications in acute respiratory viral
infections with the low degree of radical oxidation intensity is described.
Autoimmune process suppression, which is the cause of postvaccinal complications
in often ill children, by cycloferon on the background of planned vaccination is
shown. Results of cycloferon use in treatment of gastrointestinal tract disorders,
intestinal infections both of viral and bacterial genesis are presented. Cycloferon is
suggested for intestinal disbiosis correction. In 95% of children microflora restoration
to the normal level was noted. The drug use for surgical pathology, particularly for
appendicular peritonitis, with the aim to decrease postoperative complications and
also for the correction of immune disorders in children with chronic viral hepatitis A
and B, treated by complex therapy, is described. Cycloferon safety and efficiency is
confirmed by the postmarketing randomized studies.
108
K e y w o r d s : cycloferon; acute respiratory viral infections; often ill
children; chronic viral hepatitis C and B; intestinal disbiosis.
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/
у
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нарушений
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у
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детей.
/
Коррекция
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80 с.
38. Эффективность
профилактики
ОРВИ
циклоферона
в
при
организованных
проведении
коллективах.
экстренной
Методические
рекомендации для врачей / А.А. Шульдяков, С.В. Петленко, М.Г. Романцов,
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Information about the authors:
112
Romantsov Mikhail Grigorievich – Doctor of Medicine, Professor of the
department of Infectious Diseases of SEEHPT «Saint-Petersburg State Medical
Academy named after I.I.Mechnikov of Roszdrav». Тel.: 8-812-710-82-25. E-mail:
RomantsovGCP@polysan.ru
Goryacheva Larissa Georgievna – Doctor of Medicine, Head of the department
of Viral Hepatitis and Liver Diseases of the Research Institute of Children Infections.
Kovalenko Alexsandr Leonidovith - Scientific-Technological Pharmaceutical
Firm «POLYSAN», Russia, 191119, Saint-Petersburg, Ligovsky prospect, 112, tel.:
8(812)110-82-25,112-13-79,
е-mail:
sales@polysan.ru,
STPF
«POLYSAN»
www.polysan.ru
M a t e r i a l R e c e i v e d 10.02.2010 г.
1323 Петрова+
UDC: 616.28-008.14:616.8:615.2
© N.N. Petrova, 2010
Petrova N.N. Medical products for pharmacological correction of sensorineural
hearing loss // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
Saint-Petersburg state medical academy named after I.I. Mechnicov, Russia,
195067, Saint-Petersburg, Piskariovsky pr., 47. Tel.: 8(812)545-13-39, fax:
8(812)545-13-39. E-mail: mechnik@gmail.com
Summary:
In this work is represent review of literature from last 15
years about problem of pharmacological correction of sensorineural hearing loss
with the main links of pathogenesis. There are facts about modern perspective
medicines which used for pharmacological correction hearing loss such as
antihypoxants, antioxidants etc. There are positive and negative sides of this
medicines. The mast attention is for pharmacological effects. This effects are in
protective action with acoustic analyzer in protective action with acoustic analyzer.
Key
words:
sensorineural
hearing
loss;
hearing;
treatment;
antihypoxants; antioxidants.
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Information about the author:
Petrova Natalia Nikolaevna – candidate of medical sciences, assistantprofessor of the Department of Otolaryngology Herald Mechnikov Saint-Petersburg
State Medical Academy, tel. 8(812)543-94-13, e-mail: mechnik@gmail.com
M a t e r i a l R e c e i v e d 20.05.2010 г.
1289 Сологуб+
UDC 616.988-08:616.36-002
© T.V. Sologub, M.G. Romantsov, N.A. Semenyako, S.N. Kovalenko,
A.L. Kovalenko, D.S. Sukhanov, 2010
118
Sologub T.V.1, Romantsov M.G.1, Semenyako N.A.1, Kovalenko S.N.,2
Kovalenko A.L.2, Sukhanov D.S.1 Modern approach to HCV-infection treatment //
Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
1
Saint-Petersburg state medical academy named after I. I. Mechnicov, Saint-
Petersburg, Russia, 195067, Saint-Petersburg, Piskariovsky pr. 47, Tel.: 8(812)54513-39, fax: 8(812)545-13-39. E-mail: mechnik@gmail.com
2
Scientific-Technological Pharmaceutical Firm «POLYSAN», Russia, 191119,
Saint-Petersburg, Ligovsky av., 112, tel.: 8(812)110-82-25,112-13-79, е-mail:
sales@polysan.ru, STPF «POLYSAN», www.polysan.ru
Summary:
Problems of viral hepatitis C immunopathogenesis are
discussed. Special attention is paid to the increased Th1 cytokine production,
providing active protection of the body against HCV. Modern approaches to therapy
of chronic hepatitis C, described in the literature, as well as own data of the authors
including patient “thrice therapy” with the use of immunomodulators (cycloferon in a
form of injections and tablets, galavit and derinat) of different mechanism of action,
are presented. Comparative evaluation of the therapy efficiency is made. Cycloferon
was shown to be the drug of choice on the background of viral hepatitis in drug
addicts. Clinical-laboratory efficiency of remaxol - metabolic hepatoprotector with
antioxidant activity - is described. Its high efficiency in combination with good
tolerance (side effects requiring discontinuation of the drug were registered in 0,3 %
of cases) and minimum risk of the absence of biochemical remission allows to regard
remaxol as a highly effective metabolic hepatoprotector for pathogenetic therapy of
chronic hepatitis.
K e y w o r d s : hepatitis; treatment; immunopathogenesis; risk of favorable
and unfavourable disease outcomes; liver bioptate.
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Information about the authors:
Sologub Tamara Vasilievna – Doctor of Medicine, Professor, head of the
department of Infectious Diseases of the Saint-Petersburg State Medical Academy
named after I.I.Mechnikov of Roszdrav, tel./fax: 8-812-717-27-07, e-mail:
tomarasologub@rambler.ru
Romantsov Mikhail Grigorievich – Doctor of Medicine, Professor of the
department of Infectious Diseases of SEEHPT «Saint-Petersburg State Medical
Academy named after I.I.Mechnikov of Roszdrav». Тel.: 8-812-710-82-25. E-mail:
RomantsovGCP@polysan.ru
Semenyako Nadezhda Aleksandrovna – Candidate of Medical Sciences,
Assistant of the department of Infectious Diseases of the I.I.Mechnikov St.Petersburg State Medical Academy. Tel.: 8(812)274-97-54.
Kovalenko Svetlana Nikolaevna – senior teacher of the Saint-Petersburg
branch of the Modern Humanitarian Academy.
Kovalenko Alexsandr Leonidovith - Scientific-Technological Pharmaceutical
Firm «POLYSAN», Russia, 191119, Saint-Petersburg, Ligovsky prospect, 112, tel.:
8(812)110-82-25,112-13-79,
е-mail:
sales@polysan.ru,
STPF
«POLYSAN»
www.polysan.ru
Sukhanov Dmitry Sergeevich - Candidate of Medical Sciences, Assistant of the
department of Phthysiopulmonology of the I.I.Mechnikov St.-Petersburg State
Medical Academy.
M a t e r i a l R e c e i v e d 10.02.2010 г.
126
TO AUTHORS’ ATTENTION
127
Пример оформления статьи на английском языке
UDC 613.6:677
© V.M. Shmeleva, V.A. Kobilyanskaya, N.V. Aganezova, L.P. Papayan, 2010
Influence of haemocystein on plasma sensitivity to the activated C protein
V.M. Shmeleva1, V.A. Kobilyanskaya1, N.V. Aganezova1, 2, L.P. Papayan1
1
Russian Research Institute of Hematology and Transfusiology, SaintPetersburg, Russia
2
Saint-Petersburg Medical Academy for Post-Diploma Training, SaintPetersburg, Russia
Shmeleva V.M.1, Kobilyanskaya V.A.1, Aganezova N.V.2, Papayan L.P.1
Influence of haemocystein on plasma sensitivity to the activated C protein //
Preventive and clinical medicine. – 2010. - № 2 (35). – Р.
1
Federal State Institution «Russian Research Institute of Hematology and
Transfusiology of the Federal Agency for Advanced Technology Medical Aid».
Russia, 191024, St.-Petersburg, 2 Sovetskaya str., 16. Тel.: 8(812)274-56-50, fax:
8(812)717-25-50. E-mail: RNIIHT@mail.ru
2
State Educational Establishment for Additional Professional Training «Saint-
Petersburg Medical Academy for Post-Diploma Training of the Federal Agency for
Public Health and Social Development of the Russian Federation». Russia, 191015,
St.-Petersburg, Kirochnaya str., 41. Тel.: 8(812)272-52-06, fax: 8(812)273-00-39. Еmail: admin@maps.spb.ru
A b s t r a c t : subject, theme, purpose of the study, method or methodology
of the study, results of the study, field of results application, conclusions, additional
information
K e y w o r d s : через точку с запятой
Текст статьи с абзаца, включающий:
I n t r o d u c t i o n (краткое введение), далее с новых строк.
T h e p u r p o s e o f t h e s t u d y . (Шрифт подзаголовка Times New
Roman разреженный 4 пт.) Текст статьи – Шрифт Times New Roman, 14 пт.,
межстрочный интервал 1,5, выравнивание по ширине
128
Material
and
methods
of
the
study.
Текст -
выравнивание по ширине
T h e r e s u l t s o f t h e s t u d y . Текст - выравнивание по ширине
Discussion
of
study
results.
Текст - выравнивание по
ширине.
Conclusion.
Текст (по ширине) или S t u d y
F i n d i n g s (по
центру) выводы 1, 2, 3 и т.д. (с абзаца). Текст выводов - выравнивание по
ширине (поля те же, что и для всего текста).
References
(по центру). Текст списка - выравнивание по ширине
(поля те же, что и для всего текста). Составляется по алфавиту, сначала
отечественные авторы, а затем зарубежные в оригинальной транскрипции.
Соблюдение
правил
библиографического
описания
и
пунктуации
в
соответствии с ГОСТ 7.05-2008 (Введен в действие 01.01.2009 г.) – обязательно.
Information about the author(s):
Sukharev Alexander Evgenievich - doctor of medicine, head of the Astrakhan
Scientific Regional Public Institution of Humanitarian Problems «GRANT», work
tel.: (8-3912) 22-16-32, home tel.: (8-3912) 23-88-15. Е-mail: asukharev@mail.com
Afanasieva Galina Alexandrovna – candidate of medical sciences, assistantprofessor of the Department of Pathologic Physiology of Saratov State Medical
University, work tel.: (8-845-2) 66-97-91, home tel.: 8(845-2) 51-15-87, mobile
phone 8-903-384-00-97. Е-mail: gafanaseva@yandex.ru
129