WORKSHOP
EMBO workshop
Disease, Development and Stems Cells in the
Pancreas
Venue:
Bertilsalen, Karolinska Institutet, Solna, Stockholm
Dates:
14-16th June, 2010
Organizers: Helena Edlund, Umeå
Matthias Löhr, Stockholm
Mathias Treier, Heidelberg
Secretary: Rainer Heuchel, Stockholm
Program
Monday, 14th June
11:00-12:30
Registration and Lunch
12:30-13:00
Welcome and opening remarks
Harriet Wallberg-Henriksson (President, Karolinska
Institutet)
Matthias Löhr (CLINTEC, Karolinska Institutet)
Session I
Disease Genetics and Mechanisms
13:00-17:00
Chair – Mathias Treier / Maureen Gannon
Sarah Flanagan (Exeter, UK)
Monogenic disease form of Diabetes
John Todd (Cambridge, UK)
Type 1 diabetes genetics
Marc McCarthy (Oxford, UK)
Type 2 diabetes genetics
Pål Njolstad (Oslo, Norway)
CEL mutations and pancreatic dysfunction
15:00-15:30 Coffee Break
Ron Kahn (Boston, USA)
Insulin Signaling and the Pathogenesis of Diabetes
Mathias Treier (Heidelberg, Germany)
Cilia signaling and beta cell function
Carmen Guerra (Madrid, Spain)
Cancer genetics
EMBO Young Investigator Lecture
Chair – Matthias Löhr / Rainer Heuchel
17:00-17:30
Duncan Odom (Cambridge, UK)
Species-specific transcription in mice carrying human chromosome 21
Chair – Ralf Jesenofsky / Cecilia Götherström
17:30-18:00
Oral Posters (selected speakers)
Poster Session
18:00-19:00
19:00 - late Welcome party and buffet dinner
Tuesday, 15th June
Session II
Pancreatic Development
08:30-13:00
Chair – Helene Edlund / Harry Heimberg
Ewa Wandzioch (Philadelphia, USA)
Specification of pancreatic and hepatic progenitors
Klaus H. Kaestner (Philadelphia, USA)
Foxa2 and pancreatic development
Ray MacDonald (Dallas, USA)
From beginning to end: Ptf1a control of pancreatic organogenesis
Henrik Semb (Lund, Sweden)
Pancreatic tubulogenesis
10:30-11:00
Coffee break
Gérard Gradwohl (Illkirch, France)
Ngn3 and endocrine cell specification
2
Lori Sussel (New York, USA)
Nkx2.2, neuro D, and endocrine cell differentiation
Helena Edlund (Umeå, Sweden)
Retinoic acid and beta cell differentiation
Maureen Gannon (Nashville, TN, USA)
Beta cell proliferation during embryogenesis
13:00-14:00 Lunch
Session III Stem Cells
Chair – Matthias Hebrok / Eva Wandzioch
14:00-15:30
Outi Hovatta (Stockholm, Sweden)
hES cells
Katarina LeBlanc / Cecilia Götherström (Stockholm, Sweden)
Differentiating mesenchymal stem cells
Anna Wobus (Gatersleben, Germany)
ES to insulin-producing cells
15:30-16:00
Session IV
Coffee break
Pancreatic cell regeneration and
reprogramming
Chair – Jorge Ferrer / Anna Wobus
16:00-18:30
Jake Kushner (Philadelphia, PA, USA)
Adult beta cell turnover
Harry Heimberg (Brussels, Belgium)
Islet neogenesis
Patrick Collombat (Nice, France)
Pax4-mediated reprogramming of endocrine alpha-cells into beta-cells
Jorge Ferrer (Barcelona, Spain)
Plasticity of pancreatic duct cells
Ralf Jesenofsky (Heidelberg, Germany)
Reprogramming of pancreatic stellate cells
Evening free
20:00 - late
Faculty Dinner (The Royal Dramatic Theatre; invitation
only!)
3
Wednesday, 16th June
Session V
Stem Cell and Pancreatic Cancer
08:30-12:30
Chair – Rune Toftgård / Olle Ringdén
Anne Grapin Botton (Lausanne, Switzerland)
Wnt signaling in pancreatic development and cancer
Matthias Hebrok (San Francisco, USA)
HH and pancreatic tumor development in mouse models
Christopher Heeschen (Madrid, Spain)
Pancreatic cancer stem cells
10:00-10:30
Coffee Break
Rune Toftgård (Stockholm, Sweden)
sHH and pancreatic cancer development
Oral Posters (selected speakers) Chair – Christopher Heeschen /
Per-Olof Berggren
11:30-12:45
Lunch
Session VI
Clinical Applications of Stem Cells
13:30-15:30
Chair – Jörgen Larsson / Roland M. Schmid
Olle Korsgren (Uppsala, Sweden)
In vivo imaging in clinical islet transplantation
Per-Olof Berggren (Stockholm, Sweden)
In vivo imaging of transplanted islets
Frederik L. Giesel (Heidelberg, Germany)
Stem cell labeling and MRI imaging
Olle Ringdén (Stockholm, Sweden)
Use of stem cells in pancreatic cancer treatment
15:30-16:00
Coffee break
Summary
16:00-16:30
Helena Edlund (Umeå, Sweden), Mathias Treier (Heidelberg, Germany)
Concluding remarks
4
Science & Society- Plenary Discussion
16:30-18:00
Chair – Johan Permert / Matthias Löhr
Roland M. Schmid (Munich, Germany)
Jan Andersson (Stockholm, Sweden)
18:30-late
Farewell party and Reception at the Golden Hall, City Hall
5