Fairview Health Services
Research Administration
Guidance for Use of Research Animals in Patient Care Service Areas
Purpose:
To provide general and procedural guidance for the methods to employ
using research animals (live or post mortem) in patient care service areas within
Fairview-University Medical Center (F-UMC)[University Campus only]. These
guidelines will provide an overview and will address practices for pricing purposes and
practices that minimize the risk of potential exposure to patients, employees, and the
public. Additionally, these guidelines will complement and ensure compliance with the
Animal Welfare Act and the Public Health Service Act (Public Law 99-158).
Definitions:
AWA:
FV:
IACUC:
PI:
RAR:
SC:
USDA:
Animal Welfare Act
Fairview
Institutional Animal Care and Use Committee
Principal Investigator
Research Animal Resources
Study Coordinator
United States Department of Agriculture
Outline of Contents:
►Procedures to Follow
 Pricing
 Research Institutional Account Set-Up
 Scheduling
 Time of Service
 Invoicing
 Reporting
►Procedures to Follow for Unexpected Events
 Animal Bites, Scratches, & Splashes
 Animal Escapes
 Animal Death
►Useful Links
►Sources Cited
►Safety & Infection Control Plan
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Procedures to Follow for Researchers
Pricing
 CONTACT the Patient Care Service Area manager to clearly identify the
services that will be used.
 CONTACT FV Research Administration (612-672-7690) for assistance with the
pricing of requested services or with the sub-contacting process (if needed).
Research Institutional Account Setup
♫ NOTE:
A Research Institutional Account (RIA) needs to be established in order to
correctly bill for services (unless a subcontract is being used)



COMPLETE a Research Institutional Account Request Form (RIARF) after a
CUFS number has been generated for the project. The online form is available at:
http:www.fairview.org/prof/research/pdf/forms
INDICATE that the project is an animal study on the RIARF to ensure that it is
communicated to the research billing personnel.
AWAIT the receipt of the RIA number (via fax) and the customized study
encounter form (via email)
Scheduling
♫ NOTE:
In accordance with the F-UMC Infection Control Department
recommendations, the procedure can only occur when patients are not present in the
Patient Care Service Area.




SCHEDULE the procedure with the Manager of the Patient Care Service Area
REVIEW the plan & obtain approval from the Manager of the Patient Care
Service Area
PROVIDE the contact information for the responsible research personnel
ALERT the Patient Care Service Area Manager if the research animal will be
sedated and/or sacrificed in the patient care area before, during or after the
procedure.
Time of Service
♫ NOTE:
The Researcher and Research staff is responsible for developing and
adhering to the Safety and Control measures set forth in the shaded area of this section at
the time of service when the research animal is located in the Patient Care Service Area.


COMPLETE the customized study encounter form and PROVIDE it to the
Patient Care Service Area personnel.
BRING BITE KITS if non-human primates (i.e. Macaques) are the research
animals undergoing the procedure.
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
DISINFECTION of the testing equipment in the Patient Care Service Area is the
responsibility of the Researcher and/or Research Staff
FOR FAIRVIEW PERSONNEL ONLY
Charge Capture
 Radiology Area charges are entered directly into IDX rad
 All other service areas can:
 Directly key the charges into PASS
 Fax the study encounter form to the CBO (612-672-2833) and the charges
will be billed directly to the Research Account (RIA) number
Invoicing
♫ NOTE:
Invoices are created in the Fairview CBO and are mailed directly to the
designated study staff on a monthly basis
Reporting
♫ NOTE:
The Researcher and Research staff is responsible for reporting the
following events as they occur when the research animal is located in the Patient Care
Service Area:
 Animal Bites, Scratches or Splashes
(Must report if event happens to either the Research Staff and/or F-UMC staff)
 Animal Escape
 Animal Death
(See Reporting Procedures for each category below)
Procedures for Unexpected Events
►Bites, Scratches, and Splashes from Animals
ANIMAL EXPOSURE (Non-primates)


MASSAGE the wound immediately
CLEANSE and IRRIGATE the wound with soap and running water for at least
15 minutes. Use whatever supplies (disinfectants and bandages) necessary from
the First Aid Kit located in the area
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
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If the Research Staff is affected, CALL Boynton Health Service (612-625-7900)
during daytime hours or after hours GO to Fairview-University Medical Center
(F-UMC) Emergency Room (612-273-2700)
If the F-UMC staff is affected, GO to Fairview University Medical Center (FUMC) Emergency Room (612-273-2700)
NOTIFY your supervisor and take whatever measures are necessary to identify
and isolate the animal for evaluation and observation
NOTIFY the RAR Veterinarian (612-624-9100) for animal bites or scratches
RINSE the affected area with water for at least 15 minutes if feces, urine, saliva
or blood splashes into your eyes, mouth, and nose or into a cut in your skin.
REPORT the incident to your supervisor and to the Patient Care Service Area
Departmental Manager who will route the report to:
 Director of Infection Control
 Fairview Safety Officer
 Director of Research Administration
ANIMAL EXPOSURE (Non-human primates, including Macaques (i.e. Rhesus or
Cynomolgus)


REMAIN CALM
FOLLOW the procedures in the Bite Kits if you have a:
 Bite or scratch that causes bleeding
 Cage scratch that causes bleeding
 Puncture with a needle (or an object) that has previously been in a nonhuman primate
 Splashing of feces, urine, saliva or blood into your eyes, mouth, nose or
into a cut in your skin

INSTRUCTIONS FOR BITE KIT
 OPEN the sealed packet containing the scrub brush & soap
 SCRUB the affected area with the bristle side of the brush
 SWAB the affected area deeply using the viral culture
swabs, replace it in the plastic tube, and squeeze the bottom
to break the bulb
IF IN EYES, NOSE OR MOUTH
 RINSE your eyes or the affected area with water for at
least 15 minutes. DO NOT SWAB YOUR EYES

If the Research staff is bitten, CALL Boynton Health Service (612-625-7900)
during business hours or if after hours GO to Fairview-University Medical Center
(F-UMC) Emergency Room (612-273-2700).
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If the F-UMC staff is bitten, GO to Fairview University Medical Center (F-UMC)
Emergency Room (612-273-2700)
 BRING the swab and the sheet called, Boynton Health Non-Human
Primate Bite Management of Non-Human Primate Bites, Scratches or
Splashes Onto Mucous Membranes (Macaque Species) for either the
Research staff or the F-UMC staff member
CALL RAR (612-624-9100) and/or PAGE the on-call RAR veterinarian (612899-6285) as soon as possible
REPORT the incident to your supervisor and to the Patient Care Service Area
Departmental Manager who will route the report to:
 Director of Infection Control
 Fairview Safety Officer
 Director of Research Administration
► Animal Escapes
If the research animal escapes while it is located in the Patient Care Service Area:

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
SECURE the area by closing the door of the room or area
RECAPTURE the research animal if doing so would not endanger the health of
the person attempting to do so. If the researcher is unable to recapture the animal:
 CALL RAR (612-624-9100) during daytime hours or PAGE the on-call
RAR veterinarian (612-899-6285)
 CALL FV Security (612-273-4544) for further assistance in securing the
area (s).
REPORT the incident to your supervisor and to the Patient Care Service Area
Departmental Manager who will route the report to:
 Director of Infection Control
 Fairview Safety Office
 Director of Research Administration
► Animal Death in Patient Care Service Area
In the event of an UNEXPECTED research animal death:


CALL RAR (612-624-9100) during daytime hours or PAGE the on-call RAR
veterinarian (612-899-6285) for guidance on the removal and the sanitation of the
area
♫ DO NOT DISPOSE the research animal carcass in the Patient Care Service
Area Biohazard waste receptacles.
REPORT the incident to your supervisor and to the Patient Care Service Area
Departmental Manager who will route the report to:
 Director of Infection Control
 Fairview Safety Officer
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
Director of Research Administration
In the event of an EXPECTED research animal death:


NOTIFY the Patient Care Service Area Departmental Manager when scheduling
the procedure so as to prospectively communicate the plan to the appropriate
Fairview staff
FOLLOW RAR guidelines for the handling and disposal of the research animal
Useful Links
IACUC:
www.iacuc.umn.edu
RAR:
www.ahc.umn.edu.rar
FV Research: www.fairview.org
Sources Cited and Referenced
1. University of Minnesota, Animal Care Program Emergency Plan
2. Fairview Health Services Pricing Policy
3. Fairview Health Services Infection Control Plan
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Safety & Infection Control Plan
♫ NOTE:
The Researcher and Research Staff must be able to communicate,
implement and adhere to the strategies developed to address the information contained in
sections A-F (see below). Please note that most of the information requested has already
been proposed and addressed via the completion of the IACUC application and review
process. Therefore, additional information needed for Fairview appears in bold text.
►Transportation
The Researcher and Research staff must define and follow the process for which research
animals will be transported and must address:
 Locations from and to which animals will be transported
 Route via which animals will be transported
 Personnel who will transport the animals
 Equipment used to transport the animals
 Time (s) when the animal will be transported
 Name & location of research contact person(s)
►Containment
The Researcher and Research Staff must describe the containment plan to be in effect
when the research animal is located within the Patient Care Service Area to include:
 Description of the caging (size, material, ventilation, etc)
 Identification of the caging as permanent or for transportation-purposes only. For
both, include the maintenance and sanitation records
 If applicable, the procedure used when transporting the animal from the caging to
the service area equipment before, during, and after the research procedure
 Description of caging and /or restraint (chemical or physical) to be used when the
animal is undergoing the research procedure (refer to the RAR website for
Restraint and Handling of Animal Principles)
 Description of the Action Plan in the event that the animal escapes the restraint
and/or caging
►Monitoring & Animal Husbandry
The Researcher and Research Staff must identify and adhere to the animal monitoring
plan to include:
 List of personnel responsible for transporting and monitoring the animals
during the research procedure
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
Name & location of contact person(s). Contact person must be available
before, during, and after the research procedure
► Sedation
The Researcher and Research Staff must outline and inform the Patient Care
Service Area Departmental Manager at the time of scheduling to be in accordance
with the recommendations for the necessity and the use of anesthesia described in the
RAR website (refer to the “Guidelines for the Use of Anesthetics, Analgesics, and
Tranquilizers in Laboratory Animals”)
► Prevention of Zoonotic Diseases
The Researcher and Research Staff must promote the prevention of Zoonotic diseases
(those that can be transmitted from animals to humans and from humans to animals).
Prevention can be accomplished via the use of personal protective equipment and proper
animal handling and restraint. See the RAR website for more details.
► Sanitation Process
♫ NOTE: The Researcher must review the sanitation plan with the Patient Care Service
Area Departmental Manager before the time of service.
The Researcher and Research Staff must identify a sanitation plan to include:
 Procedure for cleaning and disinfection of contaminated equipment,
surfaces, and floors during or following the research procedure, including
the type of hospital grade EPA-approved disinfectant (i.e. Virex) to be used.
 Identification of personnel responsible for the sanitation process
 Description of the handling, processing and/or disposal of the soiled cleaning
supplies (i.e. separate dedicated biohazard waste bag).
 Disposal of an animal carcass (if applicable) must be in a separate dedicated
biohazard waste bag that will be removed by the research staff and must be
in accordance with the RAR guidelines (see website for more details)
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