1: Phase I Clinical Study of the Dietary Supplement, Agaricus blazei

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1: Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in
Cancer Patients in Remission
Satoshi Ohno, Yoshiteru Sumiyoshi, Katsuyoshi Hashine, Akitomi Shirato, Satoru
Kyo, Masaki Inoue
Evid Based Complement Alternat Med. 2011; 2011: 192381. Published online 2011
April 18. doi: 10.1155/2011/192381
PMCID: PMC3092499
2: Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with
therapeutic antioxidant potential in streptozotocin-induced diabetic rats
Atsuko Niwa, Takashi Tajiri, Hideaki Higashino
J Clin Biochem Nutr. 2011 May; 48(3): 194–202. Published online 2011 January 7.
doi: 10.3164/jcbn.10-78
PMCID: PMC3082073
3: The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor,
Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity
and Amelioration of Th1/Th2 Imbalance and Inflammation
Geir Hetland, Egil Johnson, Torstein Lyberg, Gunnar Kvalheim
Adv Pharmacol Sci. 2011; 2011: 157015. Published online 2011 September 6.
doi: 10.1155/2011/157015
PMCID: PMC3168293
4: Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show
similarities in their structures and their immunomodulatory effects on human
monocytic THP-1 cells
Fhernanda R Smiderle, Andrea C Ruthes, Jeroen van Arkel, Wasaporn Chanput,
Marcello Iacomini, Harry J Wichers, Leo JLD Van Griensven
BMC Complement Altern Med. 2011; 11: 58. Published online 2011 July 25.
doi: 10.1186/1472-6882-11-58
PMCID: PMC3158557
5: A Laccase with Antiproliferative and HIV-I Reverse Transcriptase Inhibitory
Activities from the Mycorrhizal Fungus Agaricus placomyces
Jian Sun, Qing-Jun Chen, Qing-Qin Cao, Ying-Ying Wu, Li-Jing Xu, Meng-Juan Zhu,
Tzi-Bun Ng, He-Xiang Wang, Guo-Qing Zhang
J Biomed Biotechnol. 2012; 2012: 736472. Published online 2012 October 3.
doi: 10.1155/2012/736472
PMCID: PMC3471028
6: Interleukin-12- and interferon-γ-mediated natural killer cell activation by
Agaricus blazei Murill
Eri Yuminamochi, Taisuke Koike, Kazuyoshi Takeda, Isao Horiuchi, Ko Okumura
Immunology. 2007 June; 121(2): 197–206. doi: 10.1111/j.1365-2567.2006.02558.x
PMCID: PMC2265935
7: Effect of Agaricus blazei Murill on the Pulmonary Tissue of Animals with
Streptozotocin-Induced Diabetes
Fábio Cangeri Di Naso, Rodrigo Noronha de Mello, Sílvia Bona, Alexandre Simões
Dias, Marilene Porawski, Alexandre de Barros Falcão Ferraz, Marc François
Richter, Norma Possa Marroni
Exp Diabetes Res. 2010; 2010: 543926. Published online 2010 May 26.
doi: 10.1155/2010/543926
PMCID: PMC2878680
8: The Anti-Tumorigenic Mushroom Agaricus blazei Murill Enhances IL-1β
Production and Activates the NLRP3 Inflammasome in Human Macrophages
Tsung-Teng Huang, David M. Ojcius, John D. Young, Yi-Hui Wu, Yun-Fei Ko, TsuiYin Wong, Cheng-Yeu Wu, Chia-Chen Lu, Hsin-Chih Lai
PLoS One. 2012; 7(7): e41383. Published online 2012 July 23.
doi: 10.1371/journal.pone.0041383
PMCID: PMC3402498
9:
An extract of the medicinal mushroom Agaricus blazei Murill can protect
against allergy
Linda K Ellertsen, Geir Hetland
Clin Mol Allergy. 2009; 7: 6. Published online 2009 May 5. doi: 10.1186/14767961-7-6
PMCID: PMC2688003
10: IL-12 Production Induced by Agaricus blazei Fraction H (ABH) Involves Tolllike Receptor (TLR)
H. Kasai, L. M. He, M. Kawamura, P. T. Yang, X. W. Deng, M. Munkanta, A.
Yamashita, H. Terunuma, M. Hirama, I. Horiuchi, T. Natori, T. Koga, Y. Amano, N.
Yamaguchi, M. Ito
Evid Based Complement Alternat Med. 2004 December; 1(3): 259–267.
doi: 10.1093/ecam/neh043
PMCID: PMC538514
11: The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and
Pharmaco-Toxicological Problems
F. Firenzuoli, L. Gori, G. Lombardo
Evid Based Complement Alternat Med. 2008 March; 5(1): 3–15. Published online
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PMCID: PMC2249742
12: Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in
Human Volunteers
Ying Liu, Yasushi Fukuwatari, Ko Okumura, Kazuyoshi Takeda, Ken-ichi Ishibashi,
Mai Furukawa, Naohito Ohno, Kazu Mori, Ming Gao, Masuro Motoi
Evid Based Complement Alternat Med. 2008 June; 5(2): 205–219. Published online
2007 April 12. doi: 10.1093/ecam/nem016
PMCID: PMC2396466
13: Preparation, characterization, and biological properties of β-glucans
Sandeep Rahar, Gaurav Swami, Navneet Nagpal, Manisha A. Nagpal, Gagan Shah Singh
J Adv Pharm Technol Res. 2011 Apr-Jun; 2(2): 94–103. doi: 10.4103/22314040.82953
PMCID: PMC3217690
14: Recent developments in mushrooms as anti-cancer therapeutics: a review
Seema Patel, Arun Goyal
3 Biotech. 2012 March; 2(1): 1–15. Published online 2011 November 25.
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PMCID: PMC3339609
15: Evaluation of Ten Wild Nigerian Mushrooms for Amylase and Cellulase
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Segun Gbolagade Jonathan, Olusegun Richard Adeoyo
Mycobiology. 2011 June; 39(2): 103–108. Published online 2011 June 16.
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16: Macro and trace mineral constituents and radionuclides in mushrooms: health
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Jerzy Falandysz, Jan Borovička
Appl Microbiol Biotechnol. 2013 January; 97(2): 477–501. Published online 2012
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PMCID: PMC3546300
17: Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK
Activation Involving the Mitochondrial Pathway and Suppression of Constitutive
NF-κB in THP-1 Cells
Mun-Ock Kim, Dong-Oh Moon, Jin Myung Jung, Won Sup Lee, Yung Hyun Choi, Gi-Young
Kim
Evid Based Complement Alternat Med. 2011; 2011: 838172. Published online 2011
February 20. doi: 10.1093/ecam/nep176
PMCID: PMC3137680
18: Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response
through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in
Mice
Go Bouike, Yosuke Nishitani, Hideyuki Shiomi, Masaru Yoshida, Takeshi Azuma,
Takashi Hashimoto, Kazuki Kanazawa, Masashi Mizuno
Evid Based Complement Alternat Med. 2011; 2011: 532180. Published online 2010
September 26. doi: 10.1155/2011/532180
PMCID: PMC2952310
19: The effects of dietary supplementation with Agaricales mushrooms and other
medicinal fungi on breast cancer: Evidence-based medicine
Maria Rita Carvalho Garbi Novaes, Fabiana Valadares, Mariana Campos Reis,
Daniella Rodrigues Gonçalves, Marilia da Cunha Menezes
Clinics (Sao Paulo) 2011 December; 66(12): 2133–2139. doi: 10.1590/S180759322011001200021
PMCID: PMC3226611
20: Antithetical effects of hemicellulase-treated Agaricus blazei on the
maturation of murine bone-marrow-derived dendritic cells
Masaki Kawamura, Hirotake Kasai, Limin He, Xuewen Deng, Atsuya Yamashita,
Hiroshi Terunuma, Isao Horiuchi, Fuminori Tanabe, Masahiko Ito
Immunology. 2005 March; 114(3): 397–409. doi: 10.1111/j.1365-2567.2004.02106.x
PMCID: PMC1782089
21: Measuring perceived effects of
Agaricus blazei murill: a survey of
James A Talcott, Jack A Clark, Insu
BMC Complement Altern Med. 2007; 7:
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drinking an extract of basidiomycetes
Japanese consumers with cancer
P Lee
32. Published online 2007 October 29.
22: Immunomodulatory dietary polysaccharides: a systematic review of the
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Jane E Ramberg, Erika D Nelson, Robert A Sinnott
Nutr J. 2010; 9: 54. Published online 2010 November 18. doi: 10.1186/1475-28919-54
PMCID: PMC2998446
23: Delayed Cell Cycle Progression and Apoptosis Induced by HemicellulaseTreated Agaricus blazei
Masaki Kawamura, Hirotake Kasai
Evid Based Complement Alternat Med. 2007 March; 4(1): 83–94. Published online
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PMCID: PMC1810359
24: The effects of whole mushrooms during inflammation
Sanhong Yu, Veronika Weaver, Keith Martin, Margherita T Cantorna
BMC Immunol. 2009; 10: 12. Published online 2009 February 20.
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PMCID: PMC2649035
25: Dietary Shiitake Mushroom (Lentinus edodes) Prevents Fat Deposition and
Lowers Triglyceride in Rats Fed a High-Fat Diet
D. Handayani, J. Chen, B. J. Meyer, X. F. Huang
J Obes. 2011; 2011: 258051. Published online 2011 October 19.
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26: The Pharmacological Potential of Mushrooms
Ulrike Lindequist, Timo H. J. Niedermeyer, Wolf-Dieter Jülich
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27: Antiinflammatory and Immunomodulating Properties of Fungal Metabolites
Cristina Lull, Harry J. Wichers, Huub F. J. Savelkoul
Mediators Inflamm. 2005 June 9; 2005(2): 63–80. doi: 10.1155/MI.2005.63
PMCID: PMC1160565
28: The effects of β-glucan on human immune and cancer cells
Godfrey Chi-Fung Chan, Wing Keung Chan, Daniel Man-Yuen Sze
J Hematol Oncol. 2009; 2: 25. Published online 2009 June 10. doi: 10.1186/17568722-2-25
PMCID: PMC2704234
29: Is there a role for complementary therapy in the management of leukemia?
Kathleen Wesa, Barrie R Cassileth
Expert Rev Anticancer Ther. Author manuscript; available in PMC 2010 July
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30: Antioxidative and Antimutagenic Activities of 70% Ethanolic Extracts from
Four Fungal Mycelia-Fermented Specialty Rices
Mi Ra Yoon, Seok Hyun Nam, Mi Young Kang
J Clin Biochem Nutr. 2008 September; 43(2): 118–125. Published online 2008
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31: Cytoprotective effect of polysaccharide isolated from different mushrooms
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Joo-Shin Kim, Hau Yin Chung, Keun Na
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32: A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi)
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NAOKI KASHIMOTO, SATOMI ISHII, YUKI MYOJIN, MITSUYASU USHIJIMA, MINORU HAYAMA,
HIROMITSU WATANABE
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33: Anti-Cancer Effects of Protein Extracts from Calvatia lilacina, Pleurotus
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Lu, Ching-Hsein Chen
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34: Anti-inflammatory activity of edible oyster mushroom is mediated through
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35: Evidence for Outcrossing via the Buller Phenomenon in a Substrate
Simultaneously Inoculated with Spores and Mycelium of Agaricus bisporus
Philippe Callac, Cathy Spataro, Aurélie Caille, Micheline Imbernon
Appl Environ Microbiol. 2006 April; 72(4): 2366–2372.
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36:
The Effect of Enzymatically Polymerised Polyphenols on CD4 Binding and
Cytokine Production in Murine Splenocytes
Daisuke Yamanaka, Yumi Tamiya, Masuro Motoi, Ken-ichi Ishibashi, Noriko N.
Miura, Yoshiyuki Adachi, Naohito Ohno
PLoS One. 2012; 7(4): e36025. Published online 2012 April 23.
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37: Polysaccharide and extracts from Lentinula edodes: structural features and
antiviral activity
Vinicius Pires Rincão, Kristie Aimi Yamamoto, Nágila Maria Pontes Silva Ricardo,
Sandra Aguiar Soares, Luzia Doretto Paccola Meirelles, Carlos Nozawa, Rosa Elisa
Carvalho Linhares
Virol J. 2012; 9: 37. Published online 2012 February 15. doi: 10.1186/1743422X-9-37
PMCID: PMC3292946
38: Herbal Medicine in the Treatment of Ulcerative Colitis
Fei Ke, Praveen Kumar Yadav, Liu Zhan Ju
Saudi J Gastroenterol. 2012 Jan-Feb; 18(1): 3–10. doi: 10.4103/1319-3767.91726
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39: Medicinal mushrooms: Towards a new horizon
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Pharmacogn Rev. 2010 Jul-Dec; 4(8): 127–135. doi: 10.4103/0973-7847.70904
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40: Malignant pleural mesothelioma
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J Med Case Reports. 2009; 3: 6800.
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41: Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE
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Evid Based Complement Alternat Med. 2012; 2012: 464238. Published online 2011
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42: A Novel Lectin with Antiproliferative and HIV-1 Reverse Transcriptase
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43: Beta-glucans in the treatment of diabetes and associated cardiovascular
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44: Extract of Pleurotus pulmonarius Suppresses Liver Cancer Development and
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46: Immunostimulation-Mediated Anti-tumor Activity of Bamboo (Sasa senanensis)
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Evid Based Complement Alternat Med. 2010 December; 7(4): 447–457. Published
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47: Role of TOLL-like Receptors in Adjuvant-Augmented Immune Therapies by T.
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49: Dendritic Cell Activation by Glucan Isolated from Umbilicaria Esculenta
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50: β-Glucan Oligosaccharide Enhances CD8+ T Cells Immune Response Induced by a
DNA Vaccine Encoding Hepatitis B Virus Core Antigen
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51: Effect of anti-glycosphingolipid monoclonal antibodies in pathogenic fungal
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53: CAM and NK Cells
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54: A Laccase with HIV-1 Reverse Transcriptase Inhibitory Activity from the
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55: Immunomodulating and Antitumor Activities of Panellus serotinus
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56: β-Glucan enhanced apoptosis in human colon cancer cells SNU-C4
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57: Pleurotus tuber-regium Polysaccharides Attenuate Hyperglycemia and
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58: Synergistic potentiation of D-fraction with vitamin C as possible
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59: Natural Products
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60: Thymoquinone attenuates diethylnitrosamine induction of hepatic
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61: Nutrition and the Development of Mushroom Flavor in Agaricus campestris
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62: Uncaria tomentosa Exerts Extensive Anti-Neoplastic Effects against the
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64: Progression of diethylnitrosamine-induced hepatic carcinogenesis in
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65: Inhibition of Lewis Lung Carcinoma Growth by Toxoplasma gondii through
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66: Genomic and Biochemical Analysis of N Glycosylation in the Mushroom-Forming
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67: Biological Activities of the Polysaccharides Produced in Submerged Culture
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68: Enhanced Production of a Novel Cyclic Hexapeptide Antibiotic (NW-G01) by
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69: Secondary Metabolites from an Algicolous Aspergillus versicolor Strain
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Antineoplastic and Apoptotic Potential of Traditional Medicines
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72: Cordyceps militaris Grown on Germinated Soybean Induces G2/M Cell Cycle
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73: Effects of Pediococcus parvulus 2.6 and its exopolysaccharide on plasma
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74: Extraction Optimization of Water-Extracted Mycelial Polysaccharide from
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75: Optimization of Synthesis, Characterization and Cytotoxic Activity of
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76: Treatment with Aqueous Extract from Croton cajucara Benth Reduces Hepatic
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77: A small scale study on the effects of oral administration of the β-glucan
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78: In vitro antiproliferative/cytotoxic activity on cancer cell lines of a
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79: Polysaccharides from the Medicinal Mushroom Cordyceps taii Show Antioxidant
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80: A Hypothesis: Supplementation with Mushroom-Derived Active Compound
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81: Regulatory T Cells, a Potent Immunoregulatory Target for CAM Researchers:
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82: Physiology of Wood-rotting Basidiomycetes: II. Nutritive Composition of
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83: Vanadium-Enriched Cordyceps sinensis, a Contemporary Treatment Approach to
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84: A Water-Soluble Polysaccharide from the Fruit Bodies of Bulgaria inquinans
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85: Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve
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86: Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest
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87: Exogenous Superoxide Dismutase: Action on Liver Oxidative Stress in Animals
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88: Antitumor and HIV-1 Reverse Transcriptase Inhibitory Activities of a
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89: Structural Characteristics and Antioxidative Capability of the Soluble
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90: Hypoglycemic and Hypocholesterolemic Effects of Botryosphaeran from
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91: The Aqueous Soluble Polyphenolic Fraction of Psidium guajava Leaves
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92: Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic
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93: Quality evaluation of mycelial Antrodia camphorata using high-performance
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94: Submerged Culture of the Mycelium of Various Species of Mushroom
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95: Potential antioxidant and antiproliferative activities of a hot-water
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96: Genotoxic evaluation of an industrial effluent from an oil refinery using
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Genet Mol Biol. 2010 Jan-Mar; 33(1): 169–175. Published online 2010 March 1.
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97: Jungle Honey Enhances Immune Function and Antitumor Activity
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Evid Based Complement Alternat Med. 2011; 2011: 908743. Published online 2010
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98: Inhibitory effects of curcumin on passive cutaneous anaphylactoid response
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Anat Cell Biol. 2010 March; 43(1): 36–43. Published online 2010 March 31.
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99: Rapid determination of polysaccharides in BianTi Soft Extract by
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100: Anti-Inflammatory Effects of Inonotus obliquus in Colitis Induced by
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101: Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus
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102: Protective effect of extract of Cordyceps sinensis in middle cerebral
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103: Cordycepin Induced MA-10 Mouse Leydig Tumor Cell Apoptosis through
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104: Chemopreventive potential of β-Sitosterol in experimental colon cancer
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105: Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS
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Yu Gao, Laurence Flori, Jérome Lecardonnel, Diane Esquerré, Zhi-Liang Hu,
Angélique Teillaud, Gaëtan Lemonnier, Francois Lefèvre, Isabelle P Oswald,
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106: A Contemporary Treatment Approach to Both Diabetes and Depression by
Cordyceps sinensis, Rich in Vanadium
Jian-You Guo, Chun-Chao Han, Yong-Mei Liu
Evid Based Complement Alternat Med. 2010 September; 7(3): 387–389. Published
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107: Investigation on the Protective Effect of α-Mannan against the DNA Damage
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Eduardo Madrigal-Santillán, José Antonio Morales-González, Manuel SánchezGutiérrez, Alicia Reyes-Arellano, Eduardo Madrigal-Bujaidar
Int J Mol Sci. 2009 February; 10(2): 395–406. Published online 2009 February 1.
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108: Effect of organic tomato (Lycopersicon esculentum) extract on the
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Elaine S. Dutra, Cristina D. Dias, Bethânia C. de Araújo, Antônio J. S. Castro,
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109: Aqueous extracts from dietary supplements influence the production of
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110: Induction of cell cycle changes and modulation of apoptogenic/antiapoptotic and extracellular signaling regulatory protein expression by water
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111: Protein and Fat Content of Some Mushrooms Grown in Submerged Culture
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112: An antitumour lectin from the edible mushroom Agrocybe aegerita.
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115: In situ observation of a cell adhesion and metabolism using surface
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116: Regulation of Cellular Metabolism and Cytokines by the Medicinal Herb
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