Program Symposium Venue: Grand Hotel, Taipei Taipei city, where the 4th East Asian Biophysics Symposium will be held, is the capital and also the political, economic and cultural center of Taiwan. It is full of vigor, vitality and multiculturalism. Recognized as the city’s landmark and well-known for its spectacular palace of traditional Chinese style, the symposium place, Grand Hotel, overlooks Taipei City and is surrounded by verdant mountains and sparkling rivers. Registration/Information Registration desk will be located at the 10F of the Grand Hotel during the following hours: Monday, Nov. 3: 13:00 ~ 18:00 10th F, Auditorium Tuesday, Nov. 4: 08:00 ~ 12:00 & 13:00 ~ 17:00 10th F, Auditorium Steering Committee Meeting Steering Committee Members only and by invitation. Tour Information Free half day City Tour to the National Palace Museum will be provided on Nov. 5, Wednesday afternoon. Options for full day Post-Symposium Tour will be on Nov. 5, Wednesday. Further and tourist information will be available on the site during the Symposium and at the Information Desk. Scientific Program 4th EABS Symposium Sessions November 3: PL1-PL2 (10th F, Auditorium) November 4 - 6: PL3-PL8, I01-I03, I25-I27, I31-I33 (10th F, Auditorium) November 4 - 6: I04-I06, I28-I30, I34-I36 (1st F, International Reception Hall) November 4 & 6: I07-I09, I16-I18, I37-I39, I46-I48 (1st F, International Reception Hall) November 4 & 6: I10-I12, I19-I21, I40-I42, I49-I51 (1st F, Conference Room 110) November 4 & 6: I13-I15, I22-I24, I43-I45, I52-I54 (1st F, Conference Room 105) November 6: PL9 (B1, Fu-Chuan Room) All Poster display at the Grand Hotel, 1st F the Corridor, from 13:30 Nov. 4 to 17:30 Nov. 5 1 Symposium Program Schedule November 3, Monday Registration/Information Desk at the Grand Hotel 10th F, Auditorium, 13:00 – 18:00 15:30 – 15:45 Welcome Address: Andrew H.-J. Wang, Academia Sinica 15:45 – 16:00 Opening Remarks: Cheng-Wen Wu, NHRI Felicia Chen-Wu Memorial Lecture 16:00 – 16:50 Plenary Lecture PL1 (10th F, Auditorium) 16:50 – 17:00 Break 17:00 – 17:50 Plenary Lecture PL2 (10th F, Auditorium) 18:00 – 21:00 Welcome Reception & Opening Ceremony, Grand Hotel 1st F, International Reception Hall November 4, Tuesday 09:00 – 10:30 Invited Lectures I01 ~ I03 Structural Biophysics (10th F, Auditorium) I04 ~ I06 Cell & Membrane Biophysics (1st F, International Reception Hall) 10:30 – 10:50 Coffee Break 10:50 – 11:40 Plenary Lecture PL3 (10th F, Auditorium) 11:40 – 12:30 Plenary Lecture PL4 (10th F, Auditorium) 12:30 – 13:30 Lunch/Photo Session (Lobby) 13:30 – 15:00 Invited Lectures I07 ~ I09 Structural Biophysics (1st F, International Reception Hall) I10 ~ I12 Biophysical Technology (1st F, Conference Room 110) I13 ~ I15 Computational Biophysics (1st F, Conference Room 105) 15:00 – 15:30 Coffee Break 15:30 – 17:00 Invited Lectures I16 ~ I18 Structural Biophysics (1st F, International Reception Hall) I19 ~ I21 Membrane Biophysics (1st F, Conference Room 110) I22 ~ I24 Imaging & Single Biophysics (1st F, Conference Room 105) 18:00 – 20:30 Steering Committee Meeting November 5, Wednesday 09:00 – 10:30 Invited Lectures I25 ~ I27 Neurobiophysics & Cell Motility (10th F, Auditorium) I28 ~ I30 Biophysical Technology (1st F, International Reception Hall) 10:30 – 10:50 Coffee Break 2 10:50 – 11:40 Plenary Lecture PL5 (10th F, Auditorium) 11:40 – 12:30 Plenary Lecture PL6 (10th F, Auditorium) 12:30 – 13:30 Lunch and Poster Viewing 13:30 ~ 17:00 All Poster display at the Grand Hotel 1st F, the Corridor, Detail of Post Symposium Tour is provided at the 4EABS Information Desk. Presenting authors are required to be present on time. 14:00 – 17:00 Free Tour to National Palace Museum (14:00, pick up at Lobby) November 6, Thursday 09:00 – 10:30 Invited Lectures I31 ~ I33 Structural Biophysics (10th F, Auditorium) I34 ~ I36 Cell & Membrane Biophysics (1st F, International Reception Hall) 10:30 – 10:50 Coffee Break 10:50 – 11:40 Plenary Lecture PL7 (10th F, Auditorium) 11:40 – 12:30 Plenary Lecture PL8 (10th F, Auditorium) 12:30 – 13:30 Lunch 13:30 – 15:00 Invited Lectures I37 ~ I39 Structural Biophysics (1st F, International Reception Hall) I40 ~ I42 Cell & Membrane Biophysics (1st F, Conference Room 110) I43 ~ I45 Multidisciplinary (1st F, Conference Room 105) 15:00 – 15:30 Coffee Break 15:30 – 17:00 Invited Lectures I46 ~ I48 Structural Biophysics (1st F, International Reception Hall) I49 ~ I51 Neurobiophysics & Cell Motility (1st F, Conference Room 110) I52 ~ I54 Computational Biophysics (1st F, Conference Room 105) 18:00 – 21:00 Banquet & Closing Ceremony, Grand Hotel B1, Fu-Chuan Room Plenary Lecture PL9 (B1, Fu-Chuan Room) November 7, Friday 08:00 – 17:00 Adjourn (Tour) 3 Plenary Lectures November 3, Monday, 16:00 – 17:50, 10th F, Auditorium Chair: Dr. Cheng-Wen Wu 16:00 – 16:50 PL1: Light And Life Lubert Stryer, Stanford University, USA Chair: Dr. Carmay Lim 17:00 – 17:50 PL2: Modeling the Structure of Proteins and Macromolecular Assemblie Andrej Sali, The Rockefeller University, USA ____________________________________________________________________________ November 4, Tuesday, 10:50 – 12:30, 10th F, Auditorium Chair: Dr. Wen-Guey Wu 10:50 – 11:40 PL3: Experimental molecular evolutions with and without cellular interaction Tetsuya Yomo, Osaka University, Japan 11:40 – 12:30 PL4: Structure and function of nickel-containing superoxide dismutase Sa-Ouk Kang, Seoul National University, Korea ____________________________________________________________________________ November 5, Wednesday, 10:50 – 12:30, 10th F, Auditorium Chair: Dr. Y. Henry Sun 10:50 – 11:40 PL5: Protein systems in excitation-contraction coupling Do Han Kim, Kwangju Institute of Science and Technology, Korea 11:40 – 12:30 PL6: Decision Making In Drosophila Facing Competing Visual Cues Aike Guo, Chinese Academy of Sciences, China ____________________________________________________________________________ November 6, Thursday, 10:50 – 12:30, 10th F, Auditorium Chair: Dr. Sheng-Hsien Lin 10:50 – 11:40 PL7: Is water essential for life? An approach through hydration structure analysis of proteins Masayoshi Nakasako, Keio University, Japan 4 11:40 – 12:30 PL8: Structure and Function of Nickel-containing Superoxide Dismutase Jun Wang, Beijing Genomics Institute, China ______________________________________________________________________ November 6, Thursday, 20:00 – 20:30, B1, Fu-Chuan Room Chair: Dr. Tai-Huang Huang 18:00 – 21:00 PL9: New NMR Approaches to Protein-Protein and Protein-Ligand Interactions James Prestegard, The University of Georgia, USA Invited Lectures Structural Biophysics (I01-03, I07-09, I16-18, I31-33, I37-39, I46-48) November 4, Tuesday, 09:00 – 10:30 Chair: 09:00 10th F, Auditorium Dr. Shwu-Huey Liaw I01: Self-assembly and switching of the bacterial flagellum Keiichi Namba, Osaka University 09:30 I02: Non-Specific Nucleases Involved in Cell Defense Hanna S. Yuna, Academia Sinica 10:00 I03: The crystal structure of the B. subtilis CodW, a new N-terminal Ser nucleophile peptidase, and its complex structure with E. coli HslV Soo Hyun Eom, Kwangju Inst. of Science & Technology ----------------------------------------------------------------------------------------November 4, Tuesday, 13:30 – 17:00 Chair: 13:30 1st F, International Reception Hall Dr. Chun-Jung Chen I07: Structure and Interactions of a Malarial Vaccine Candidate, AMA1, from the Parasite Plasmodium falciparum Raymond S. Norton, Walter & Eliza Hall Inst. of Med. Research 14:00 I08: Open-closed conformational change of H+-ATPase β subunit revealed by down-sizing NMR Hideo Akutsu, Osaka University 14:30 I09: Clean SEA-HSQC: a method to map solvent exposed amides in large non-deuterated proteins with gradient-enhanced HSQC Guang Zhu, The Hong Kong Univ. of Science & Technology 5 --------------------------------------------------------------------------------Chair: 15:30 Dr. Gu-Gang Chang (1st F, International Reception Hall) I16: Non-Canonical Watson-Crick Base Pairs Shan-Ho Chou, National Chung-Hsing University 16:00 I17: Advanced Electron Paramagnetic Resonance in Metalloenzyme Research Hong-In Lee, Seoul National University 16:30 I18: NMR snap shots of a fluctuating protein structure. Ubiquitin at 3 kbar Kazuyuki Akasaka, Kinki University ----------------------------------------------------------------------------------------10th F, Auditorium November 6, Thursday, 09:00 – 10:30 Chair: 09:00 Dr. Chi-Fon Chang I31: Structural Understanding of The Allosteric Conformational Change of Cyclic AMP Receptor Protein by Camp Binding Bong-Jin Lee, Seoul National University 09:30 I32: Compressibility-structure-function relationship of proteins Kunihiko Gekko, Hiroshima University 10:00 I33: Biophysical Characteristics of Cytotoxic Ribonucleases from Rana catesbeiana Chinpan Chen, Academia Sinica ----------------------------------------------------------------------------------------1st F, International Reception Hall November 6, Thursday, 13:30 – 17:00 Chair: 13:30 Dr. Chuan-Deng Hsiao I37: Role of non-planar amino groups in DNA structural rigidity Rabi Majumdar, University of Calcutta 14:00 I38: The coiled-coil region of gp41: Its role in membrane fusion and theapplication for a new target for anti-HIV agent Yeon Gyu Yu, Korea Institute of Science and Technology 14:30 I39: Crystal Structure of the BAFF and BAFF-R Complex: Implications for the Receptor Activation Jie-Oh Lee, Kwangju Institute of Science and Technology --------------------------------------------------------------------------------- 6 Chair: 15:30 Dr. Der-Lii Tzou (1st F, International Reception Hall) I46: NMR Studies of intact Spermatozoa Girjesh Govil, Tata Institute of Calcutta 16:00 I47: Conformation of the M1 Segment of the Nicotinic Acetylcholine Receptor in a Membrane Environment. Frances Separovic, University of Melbourne 16:30 I48: Crystal structure of human tryptophanyl-tRNA synthetase at 3.0 Å resolution Jian-Ping Ding, Shanghai Institute for Biology Science Cell & Membrane Biophysics (I04-06, I19-21, I34-36, I40-42) November 4, Tuesday, 09:00 – 10:30 Chair: 09:00 1st F, International Reception Hall Dr. Pei-Yeh Chen I04: Study signaling mechanisms of programmed cell death in a single living cell Donald C. Chang, Hong Kong University of Science and Technology 09:30 I05: Diffusion barrier in the initial segment membrane of neurons as revealed by single molecule nanotechnologies Chieko Nakada, Nagoya University 10:00 I06: Membrane binding and ion channel formation of tolaasin, a Pseudomonas peptide toxin Young-Kee Kim, Chungbuk National University ------------------------------------------------------------------------------------November 4, Tuesday, 15:30 – 17:00 1st F, Conference Room 110 Chair: 15:30 Dr. Wen Chang I19: Single Molecular and Cellular Fluorescence-Absorption Spectroscopy of Photosynthetic Systems at 4-300K Shigeru Itoh, Nagoya University 16:00 I20: Structure-based Focal Adhesion Signaling Mediated by Syndecan Proteoglycans Weontae Lee, Yonsei University 16:30 I21: Functional regulation of the main light-harvesting chlorophyll a/b-protein complex through conformational rearrangement Hui Chen, Institute of Bot, Chin Acad of Science ----------------------------------------------------------------------------------------- 7 November 6, Thursday, 09:00 – 10:30 1st F, International Reception Hall Chair: Dr. W.-J. Chuang 09:00 I34: Altered sarcoplasmic reticular Ca2+-uptake function of H9c2 cells cultured in high glucose medium Hae Won Kim, University of Ulsan College of Medicine 09:30 I35: Structural and mechanistic studies of photosynthetic water oxidation by light-induced ftir difference spectroscopy Hsiu-An Chu, Academia Sinica 10:00 I36: Spinal glycine receptors are the targets of the general anesthetics Tian-Le Xu, University of Science & Technology Of China ------------------------------------------------------------------------------------November 6, Thursday, 13:30 – 15:00 1st F, Conference Room 110 Chair: 13:30 Dr. Ping-Chiang Lyu I40: Fluorescence Resonance Energy Transfer (FRET) Study on Interaction of Heat Shock Protein hsp27 with p38 MAP kinase in Single Living Cell Xu Shen, Chinese Academy of Sciences, China 14:00 I41: Molecular and Brownian dynamics simulations of ion channels Serdar Kuyucak, University of Sydney 14:30 I42: Sensitization of regulated exocytosis by protein Kinase C Tao Xu, Huazhong University Neurobiophysics & Cell Motility (I25-27, I49-51) November 5, Wednesday, 09:00 – 10:30 Chair: 10th F, Auditorium Dr. Zee-Fen Chang 09:00 I25: Rapid Action and Local Synthesis of Neurosteroids in the Brain Hippocampus: Their Role in Synaptic Transmission and Learning and Memory Suguru Kawato, University of Tokyo 09:30 I26: Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null Cells Hong-Chen Chen, National Chung Hsing University 10:00 I27: Cross-talk between nicotinic and muscarinic ACh-receptors in rat superior cervical ganglion neurons Zhuan Zhou, Inst. of Neuroscience, Chin Acad Sci. 8 ----------------------------------------------------------------------------------------November 6, Thursday, 15:30 – 17:00 1st F, Conference Room 110 Chair: 15:30 Dr. Po-Huang Liang I49: Ca2+-Activated K+ Channels in Mammalian Central Nervous System: Their Biophysical Characteristics and Molecular Mechanisms Chul-Seung Park, Kwangju Inst. of Science & Technology 16:00 I50: Molecular mechanisms of acquisition and extinction of memory Po-Wu Gean, National Cheng-Kung University 16:30 I51: Azimuth-tuning Characteristics of Auditory Cortical Neurons Jun-Xian Shen, Institute of Biophysics, Chin Acad Sci. Biophysical Technology (I10-12, I28-30) November 4, Tuesday, 13:30 – 15:00 1st F, Conference Room 110 Chair: 13:30 Dr. Steve S.-F. Yu I10: Proteome Imaging of Model Macromolecular Systems Holland R. Cheng, Karolinska Inst. Struc. Virol. 14:00 I11: Free Fitness as a Measure of Biological Information, the Determinant of Molecular Evolution Yuzuru Husimi, Saitama University 14:30 I12: Optical visualization and measurement of biomolecule monolayer and biomolecule interaction as well as Proteinchip applications Gang Jin, Institute of Mechanics, Chin Acad Sci. ----------------------------------------------------------------------------------------November 5, Wednesday, 09:00 – 10:30 Chair: 09:00 1st F, International Reception Hall Dr. Yen-Chywan Liaw I28: Application of thin film phase plates in biological electron microscopy Radostin Danev, Okazaki National Research Institute 09:30 I29: Optical heterodyne Surface Plasmon Resonance (SPR) biosensor Chien Chou, National Yang-Ming University 10:00 I30: An eight-dimensional microscope and simultaneous structure & function measurements on living cells Yao-Xiong Huang, Ji-Nan University 9 Computational Biophysics (I13-15, I52-54) November 4, Tuesday, 13:30 – 15:00 1st F, Conference Room 105 Chair: 13:30 Dr. Ying-Ta Wu I13: Prolyl Cis-Trans Isomerization of Proline, Pseudoproline, and Oligoprolines Young Kee Kang, Chungbuk National University 14:00 I14: Jumping-Among-Minima Model: Unified View for Energy Landscape of Native Proteins Akio Kitao, The University of Tokyo 14:30 I15: Multiscale molecular simulations of protein kinase C membrane targeting mechanism Jung-Hsin Lin, National Taiwan University ----------------------------------------------------------------------------------------November 6, Thursday, 15:30 – 17:00 1st F, Conference Room 105 Chair: 15:30 Dr. Ming-Jing Hwang I52: Protein Folds, Functions and Evolution Ueng-Cheng Yang, Yang-Ming University 16:00 I53: A trial of genome function prediction through gene positional information in the case of DNA repair proteins Kei Yura, Japan Atom. Energy Research Institute 16:30 I54: Amplifying collective motions in computer simulations of proteins and peptides Haiyan Liu, Univ. of Science & Technology Of China Imaging & Single Biophysics (I22-24) November 4, Tuesday, 15:30 – 17:00 1st F, Conference Room 105 Chair: 15:30 Dr. Lou-Sing Kan I22: Torque-speed relationship of the Na+-driven flagellar motor Akihiko Ishijima, Nagoya University 16:00 I23: Near-field and far-field single molecule fluorescence Spectroscopy Wunshain Fann, Academia Sinica 16:30 I24: Single Molecule Imaging and Quantitative Analysis of Molecular Interactions Inside Cells Makio Tokunaga, National Inst. Genetics 10 Join Section (I43-45) November 6, Thursday, 13:30 – 15:00 1st F, Conference Room 105 Chair: 13:30 Dr. Tzu-Ching Meng I43: From optical trapping to single-particle spectroscopy & optical force microscopy for Bio- and Nano- applications Arthur Chiou, National Yang-Ming University 14:00 I44: Protein-structure annotation database (GTOP) and its application to genome wide comparison of proteins from bacteria living in extreme environments Satoshi Fukuchi, National Institute of Genetics 14:30 I45: Away from the edge: SAD phasing from the sulfur anomalous signal measured in-house with chromium radiation Cheng Yang, Rigaku/MSC, Inc. List of Abstracts Plenary Lectures P01 Lubert Stryer Light and Life P02 Andrej Sali Modeling the structure of proteins and macromolecular assemblies P03 Tetsuya Yomo Experimental molecular evolutions with and without cellular interaction P04 Sa-Ouk Kang Structure and Function of Nickel-containing Superoxide Dismutase P05 Do Han Kim Protein systems in excitation-contraction coupling P06 Aike Guo, Shiming Tang, Jianzeng Guo, Ke Zhang, Yueqing Peng and Wang Xi Decision Making in Drosophila Facing Competing Visual Cues P07 Masayoshi Nakasako Is water essential for life? An approach through hydration structure analysis of proteins P08 Jun Wang The Chinese Hybrid Rice Genome Project 11 P09 James H. Prestegard New NMR Approaches to Protein-Protein and Protein-Ligand Interactions Invited Lectures I01 Keiichi Namba Self-assembly and switching of the bacterial flagellum I02 Hanna S. Yuan, Chia-Lung Li, Kuo-Chiang Hsia, Kin-Fu Chak and Lien-I Hor Non-Specific Nucleases Involved in Cell Defense I03 Seong-Hwan Rho, Hyun Ho Park, Young Jun Lim, Min Suk Kang, Byung Kook Lim, Ihn Sik Seong, Chin Ha Chung, Jimin Wang, and Soo Hyun Eom The crystal structure of the B. subtilis CodW, a new N-terminal Ser nucleophile peptidase, and its complex structure with E. coli HslV I04 Donald C. Chang Study signaling mechanisms of programmed cell death in a single living cell I05 Chieko Nakada, Kenneth Ritchie, Yuichi Oba, Mitsuhiro Nakamura, Yoko Hotta, Ryota Iino, Rinshi S. Kasai, Kazuhiko Yamaguchi, Takahiro Fujiwara, & Akihiro Kusumi Diffusion barrier in the initial segment membrane of neurons as revealed by single molecule nanotechnologies I06 Young-Kee Kim Purification and Ion Channel Formation of a Pseudomonas Peptide Toxin, Tolaasin I07 Raymond S. Norton Structure and interactions of a malarial vaccine candidate, AMA1, from the parasite Plasmodium falciparum I08 Hideo Akutsu, Hiromasa Yagi, Toshio Yamazaki and Masasuke Yoshida Open-closed conformational change of H+-ATPase subunit revealed by down-sizing NMR I09 Donghai Lin, Kong Hung Sze, and Guang Zhu Clean SEA-HSQC: a method to map solvent exposed amides in large non-deuterated proteins with gradient-enhanced HSQC I10 Li Xing, Leif Bergman, Josefina Nilsson, Lars Haag, Sunny Wu, Nicklas Lof, Joseph Wang, Anders Wallande, Bomu Wu, Jan Sedzik, Lena Hammar, Kjell Hultenby, Henrik Garoff, and R Holland Cheng Proteome Imaging of Model Macromolecular Systems I11 Yuzuru Husimi and Takuyo Aita 12 Free Fitness as a Measure of Biological Information, the Determinant of Molecular Evolution I12 Gang Jin Optical visualization and measurement of biomolecule monolayer and biomolecule interaction as well as Proteinchip applications I13 Young Kee Kang Prolyl Cis-Trans Isomerization of Proline, Pseudoproline, and Oligoprolines I14 Akio Kitao Jumping-Among-Minima Model: Unified View for Energy Landscape of Native Proteins I15 Jung-Hsin Lin Multiscale molecular simulations of protein kinase C membrane targeting mechanism I16 Shan-Ho Chou Non-Canonical Watson-Crick Base Pairs I17 Hong-In Lee, Jin-won Lee, Tran-Chen Yang, Robert Igarashi, Mikhail Laryukhin, Peter E. Doan, Joshua Telser, Lance C. Seefeldt, Dennis R. Dean, Sa-Ouk Kang, and Brian M. Hoffman Advanced Electron Paramagnetic Resonance in Metalloenzyme Research I18 Ryo Kitahara, Shigeyuki Yokoyama, and Kazuyuki Akasaka NMR snap shots of a fluctuating protein structure. Ubiquitin at 3 kbar I19 Shigeru Itoh, Kana Sugiura, Yuzuru Shibata, Hiroyuki Mino, Hitoshi Tamiaki and Yoshitaka Saga Single Molecular and Cellular Fluorescence-Absorption Spectroscopy of Photosynthetic Systems at 4-300K I20 Weontae Lee, Jun Shin, Bon-Kyoung Koo, Hye-Seo Park Structure-based Focal Adhesion Signaling Mediated by Syndecan Proteoglycans I21 Jing Leng, Hui Chen, Liangbi Li Functional regulation of the main light-harvesting chlorophyll a/b-protein complex through conformational rearrangement I22 Akihiko Ishijima and Yoshiyuki Sowa Torque-speed relationship of the Na+-driven flagellar motor I23 Wunshain Fann Near-field and far-field single molecule fluorescence Spectroscopy I24 Makio Tokunaga 13 Single Molecule Imaging and Quantitative Analysis of Molecular Interactions Inside Cells I25 Suguru Kawato Rapid Action and Local Synthesis of Neurosteroids in the Brain Hippocampus: Their Role in Synaptic Transmission and Learning and Memory I26 Hong-Chen Chen Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null Cells I27 Lin-Ling He and Zhuan Zhou Cross-talk between nicotinic and muscarinic ACh-receptors in rat superior cervical ganglion neurons I28 Radostin Danev, Kuniaki Nagayama and Nobuteru Usuda Application of thin film phase plates in biological electron microscopy I29 Chien Chou Optical heterodyne Surface Plasmon Resonance (SPR) biosensor I30 Yao-Xiong Huang An eight-dimensional microscope and simultaneous structure & function measurements on living cells I31 Hyung-Sik Won, T. Yamazak, and Bong-Jin Lee Structural understanding of the allosteric conformational change of cyclic AMP receptor protein by cAMP binding I32 Kunihiko Gekko Compressibility-structure-function relationship of proteins I33 Yuan-Chao Lou, Chun-Hua Hsu, Yun-Ru Pan, Yi-Hsuan Ho, Chung-De Chen, You-Di Liao, Chinpan Chen Biophysical characteristics of cytotoxic ribonucleases from Rana catesbeiana I34 Eun Hee Lee, Young-Hoon Kim, Hye Kyung Lee, and Hae Won Kim Altered sarcoplasmic reticular Ca2+-uptake function of H9c2 cells cultured in high glucose medium I35 Hsiu-An Chu Structural and mechanistic studies of photosynthetic water oxidation by light-induced FTIR difference spectroscopy I36 Tian-Le Xu, Hui Lü, Xian-Ping Dong, Zheng-Xiong Zhang Spinal glycine receptors are the targets of the general anesthetics I37 Rabi Majumdar, Anjan K. Dasgupta and Dhananjay Bhattacharyya Role of non-planar amino groups in DNA structural rigidity 14 I38 Yeon Gyu Yu The coiled-coil region of gp41: Its role in membrane fusion and the application for a new target for anti-HIV agent I39 Jie-Oh Lee Crystal Structure of the BAFF and BAFF-R Complex: Implications for the eceptor Activiation I40 Chunlei Zheng, Ziyang Lin, Yajun Yang, Hanben Niu and Xun Shen Fluorescence Resonance Energy Transfer (FRET) Study on Interaction of Heat Shock Protein hsp27 with p38 MAP kinase in Single Living Cell I41 Serdar Kuyucak Molecular and Brownian dynamics simulations of ion channels I42 Tao Xu Sensitization of regulated exocytosis by protein Kinase C I43 Arthur Chiou From optical trapping to single-particle spectroscopy & optical force microscopy for Bio- and Nano- applications I44 Satoshi Fukuchi Protein-structure annotation database (GTOP) and its application to genome wide comparison of proteins from bacteria living in extreme environments I45 C. Yang, J. W. Pflugrath, D. A. Courville, C. N. Stence and J. D. Ferrara Away from the edge: SAD phasing from the sulfur anomalous signal measured in-house with chromium radiation I46 Girjesh Govil NMR Studies of intact Spermatozoa I47 M.R.R. de Planque, D.T.S. Rijkers and F. Separovic Conformation of the M1 segment of the nicotinic acetylcholine receptor in a membrane environment I48 Jianping Ding, Yadong Yu, Yunqin Liu, Xiang Xu, Zhen Xu, Feng Xu, Jie Jia, Youxin Jin, and Edward Arnold Crystal structure of human tryptophanyl-tRNA synthetase at 3.0 Å resolution I49 Chul-Seung Park Ca2+-Activated K+ Channels in Mammalian Central Nervous System: Their Biophysical Characteristics and Molecular Mechanisms I50 Po-Wu Gean Molecular mechanisms of acquisition and extinction of memory I51 Jun-Xian Shen 15 Azimuth-tuning Characteristics of Auditory Cortical Neurons I52 Yuh-Fan Liu and Ueng-Cheng Yang Protein Folds, Functions and Evolution I53 Kei Yura, Hidetoshi Kono, Nobuhiro Go A trial of genome function prediction through gene positional information in the case of DNA repair proteins I54 Haiyan Liu, Zhiyong Zhang, Jianbin He, Yunyu Shi Amplifying collective motions in computer simulations of proteins and peptides Poster Session I. Structural Biophysics PS01 Chin-Yu Chen, Ting-Wan Lin, Chia-Cheng Chou, Tzu-Ping Ko and Andrew H.-J. Wang Probing the DNA kink structure induced by the hyperthermophilic chromosomal protein Sac7d using site-directed mutagenesis and X-ray crystallography PS02 Rita P.-Y. Chen, Chun-Cheng Lin, Yin-Ting Chang, Su-Ching Lin and Sunney I. Chan The coil-to-structural transition of the prion peptide can be affected by a single O-linked sugar PS03 Tzu-Ping Ko, Sing-Yang Chang, Po-Huang Liang, and Andrew H.-J. Wang Catalytic Mechanism Revealed by the Crystal Structure of Undecaprenyl Pyrophosphate Synthase in Complex with Sulfate, Magnesium and Triton PS04 Chun-Hua Hsu, Jeu-Ming P. Yuann, Andrew H. Wang Structure detemination and DNA-binding properties of Sso7C4, a thermostable protein from the archaeon Sulfolobus solfataricus PS05 Chi-Fon Chang, Shin-Jye Lee, Yi-Jan Lin, Bin-Nan Chen, Tai-Huang Huang Structure and Backbone Dynamics of proteins from the transacylase component of Human Mitochondrial Branched-Chain alpha-Ketoacid Dehydrogenase PS06 Chung-ke Chang, Tsan-hung Yu, Hsin-hao Hsiao, Hsiao-yi Hung, Shin-Jye Lee, Shih-Che Sue and Tai-huang Huang Identification of A Dimer-Forming Region In SARS-CoV Nucleocapsid Protein PS07 Shih-Che Sue, Tzu-Feng Fu, Jeou-Yuan Chen, and Tai-huang Huang Structural and Functional Characterization of Human Hepatoma-Derived Growth Factor (hHDGF) PS08 C.Y. Chou, S.I. Tyukhtenko, Y.T. Huang and T. H. Huang 16 Backbone Dynamics and Thermodynamics of Escherichia coli Theosterase / Protease I – A temperature-dependent 15N-NMR study PS09 Shin-Jye Lee, Mandar T. Naik, Yu-Chu Chang, Bin-Nan Chen and Tai-huang Huang Folding Mechanism and Thermodynamics of the Lypoyl-Bearing Domain of the E2 Component of Human Mitochondrial Branched Chain -Ketoacid Dehydrogenase PS10 Sergiy I. Tyukhtenko, Alexandra V. Litvinchuk, Chi-Fon Chang, Jei-Fu Shaw and Tai-huang Huang NMR Investigation of the Structure and Catalytic Mechanism of a Serine Protease-E.coli Thioesterase/Protease I PS11 Kuo-Chiang Hsia, Kin-Fu Chak, Po-Huang Liang, Yi-Sheng Cheng, Wen-Yen Ku, and Hanna S. Yuan DNA Binding and Degradation by the HNH Protein ColE7 PS12 Hui-Chun Cheng, Pei-Tsung Cheng, Peiyu Peng, Ping-Chiang Lyu and Yuh-Ju * Sun Structural Basis of the Lipid Binding in Rice Nonspecific Lipid Transfer Protein-1 Complexes from Oryza sativa PS13 Jia-Yin Tsai, Sheng-Kuo Chiang, Cheng-Yang Huang, Yuh-Shyong Yang, Yuh-Ju Sun Preliminary X-ray Diffraction Analysis of Hydantoinase from Pig Liver and Agrobacterium radiobacter PS14 Wei Jyun Chien Conformation and Orientation of Somatostatin on Sodium Dodecyl Sulfate micelle PS15 Wei Jyun Chien, Chien-Pin Hsu Conformation of Sodefrin: a Female-Attracting Peptide Pheromone in newt PS16 Chia-Lung Li, Lien-I Hor, Zee-Fen Chang, Li-Chu Tsai, Wei-Zen Yang and Hanna S. Yuan DNA binding and cleavage by the periplasmic endonuclease Vvn from Vibrio vulnificus: A novel structure with a known active site PS17 Hong-Hsiang Guan Shao-Chen Lee, Wen-Guey Wu, Chung-Jung Chen Crystal structure of CTX A3 and hexasaccharide heparin complex from Naja atra PS18 Yu-Lin Wang, Shao-Chen Lee, King-Xiang Goh, Wen-guey Wu 2 and Chun-Jung Chen Purification and Crystallization of Natrin, a Cystein-rich Secretory Protein, from Naja atra 17 PS19 Wen-Chen Huang, Tzu-Ping Ko, Steven S.-L. Li and Andrew H.-J. Wang The 3-D Structure and Surface Properties of Human Post-Translational Modifier Proteins SUMO-1/2/3 PS20 Ming-Hon Hou, Howard Robinson, Yi-Gui Gao and Andrew H.-J. Wang Crystal structure of the chromomycin A3-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by metal ion. PS21 Sz-Wei Wu, Tzu-Ping Ko, Chia-Cheng Chou and Andrew H.-J. Wang Design and characterization of a multimeric DNA binding protein using Sac7d and GCN4 as templates PS22 Annie Pei-Chun Chen, Yi-Kai Chen, Yi-Hung Chen, Shiao-Chung Chuang, Chao-Tsen Chen, and Po-Huang Liang Probing the Conformational Change of E. coli Undecaprenyl Pyrophosphate Synthase during Catalysis Using an Inhibitor and Tryptophan Mutants PS23 Rey-Ting Guo, Chia-Cheng Chou, Tzu-Ping Ko, Hui-Lin Shr, Po-Huang Liang and Andrew H.-J. Wang Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of ProductChain Length Determination PS24 Nicole N.-W. Kuo, Joseph J.-T. Huang, Rita P.-Y. Chen, Su-Ching Lin, Sunney I. Chan Studies of the structural determinants in a short β-sheet peptide PS25 Hsing-Mao Chu, Rey-Ting Guo, Chia-Cheng Chou, Hui-Lin Shr, Hui-Lin Lai, Crystal structure of phytase from Selenomonas ruminantium and its complex with persulfated phytate in two binding states PS26 Sheng-Wei Lin, Jen-Ru Li, Tsui-Min Yuan, Chun-Hung Lin C-Terminal Truncation of Helicobacter pylori Fucosyltransferase Improving the Protein Overproduction, Solubility and Activity PS27 Sing-Yang Chang, Tzu-Ping Ko, Yi-Kai Chen, Po-Huang Liang and Andrew H.-J. Wang Catalytic mechanism revealed by the crystal structure, Identification of the Active Conformation and the Importance of Length of the Flexible Loop 72-83 in Regulating the Conformational Change in Undecaprenyl Pyrophosphate Synthase PS28 Ming-Feng Hsu, Tzu-Ping Ko, and Andrew H.-J. Wang Structural Analysis and Protein Engineering of RD1, a Type III Antifreeze Protein PS29 Y. M. Wang, H. F. Peng and I. H. Tsai Structures and Disulfide Bonds of Venom Phospholipases A2 in Two Primitive Tree Vipers: Trimeresurus puniceus and Trimeresurus borneenesis 18 PS30 PS31 Tzann-Shun Hwang, T. Booma Kasthuri, Chin Fen Teo, Xing-Hung Hwang, Yu-Ju Chen, Chun-Hung Lin Biophysical and Biochemical Characterization on the Quaternary Structure of Sialic Acid Synthase Jui-Chuan Chen, Tzann-Shun Hwang, Chiung-Fang Chang, Chun-Hung Lin Role of the Cysteine Residues in Sialic Acid Synthase PS32 Hui-ju Chen, Pei-Chien Tsai, Nai-Chen Wang, Tzu-Ping Ko, Chia-Yin Lee, and Andrew H.-J. Wang Crystallization, and Preliminary X-ray Analysis of L-aspartate beta-decarboxylase (Alcaligenes faecalis) from Escherichia coli PS33 Yuan-Chao Lou, Chun-Hua Hsu, Yun-Ru Pan, Yi-Hsuan Ho, Chung-De Chen, You-Di Liao, Chinpan Chen Biophysical Characteristics of Cytotoxic Ribonucleases from Rana catesbeiana PS34 Ta-Tsen Soong, Ming-Jing Hwang and Chung-Ming Chen Automatic Discovery of Recurrent Local Structures for Approximating Three-Dimensional Protein Molecules PS35 Kazuhiko Hosono, Taro Ueno, Hideki Taguchi, Fumihiro Motojima, Tamotsu Zako, Masasuke Yoshida and Takashi Funatsu Conformational Change of GroEL studied by Tyrosine Fluorescence PS36 Atsushi Matsuura, Mineyuki Mizuguchi, Takahide Kono, Kimiaki Matsubara and Keiichi Kawano The Study of the Interaction between Transthyretin and Amyloid -Protein by NMR PS37 Yasuto Todokoro, Hajime Yanagishita, Kang. S. W., Toshimichi Fujiwara and Hideo Akutsu Structural Analysis of Membrane-Bound Mastoparan-X by Solid-State NMR PS38 Naoki Yahata, Takashi Saitoh, Asuka Nakahara, Hideaki Ogata, Yoshiki Higuchi, and Hideo Akutsu NMR Investigation on the Interaction of Cytochrome c3 with its Physiological Partner [NiFe] Hydrogenase PS39 Masanobu Yoshida, Kunio Shitara, Kimiaki Matsubara, Takahide Kouno, Tomoyasu Aizawa, Yoichi Hayakawa, Yasuhiro Kumaki, Mineyuki Mizuguchi, Makoto Demura, Katsutoshi Nitta, and Keiichi Kawano Role of flexible N-terminal residues in biological activity of the insect cytokine, growth blocking peptide (GBP) PS40 Makoto Takeuchi, Mineyuki Mizuguchi, Atsushi Matsuura, Kimiaki Matsubara and Keiichi Kawano Effects of the amino acid substitutions in the DE loop of transthyretin on the protein structure and amyloid fibril formation 19 PS41 Yutaka Suzuki, Mitsuru Haruki, Kazufumi Takano, Masaaki Morikawa and Shigenori Kanaya Possible Involvement of a FKBP family Peptidyl-prolyl cis-trans Isomerase from Psychrotrophic Bacterium Shewanella sp. SIB1 in Cold-Adaptation PS42 Dmitri Lando, Alexander Fridman and Valentina P. Egorova Cross-Linking Effect Caused by Local Stabilization of the Double Helix PS43 Masanobu Yoshida, Kunio Shitara, Kimiaki Matsubara, Takahide Kouno, Tomoyasu Aizawa, Yoichi Hayakawa, Yasuhiro Kumaki, Mineyuki Mizuguchi, Makoto Demura, Katsutoshi Nitta, and Keiichi Kawano Role of flexible N-terminal residues in biological activity of the insect cytokine, growth blocking peptide (GBP) PS44 Seo-Jeong Jung, Hyung-Sik Won, Sang-Ho Park, and Bong-Jin Lee Structure-function relationship of gaegurin 5, an antimicrobial peptide isolated from a Korean frog PS45 Min-Duk Seo, Hyung-Sik Won, and Bong-Jin Lee Structure-function relationship of peptide analogues of gaegurin 4, an antimicrobial peptide isolated from a Korean frog PS46 Jin-Won Lee, Tran-Chen Yang, Hong-In Lee, Sa-Ouk Kang and Brian M. Hoffman Active Site Structure of Ni-Containing Superoxide Dismutase (Ni-SOD) PS47 Kuo Kan Liang, Michitoshi Hayashi, YingJen Shiu, Yu-Lin Yeh, C. H. Chang and Sheng Hsieh Lin Theoretical studies of protein-folding thermodynamics and kinetics - A Mean Field Theory PS48 Jia-Yin Tsai, Sheng-Kuo Chiang, Cheng-Yang Huang, Yuh-Shyong Yang, Yuh-Ju Sun Preliminary X-ray Diffraction Analysis of Hydantoinase from Pig Liver and Agrobacterium radiobacter PS49 Hui-Chun Cheng, Pei-Tsung Cheng, Peiyu Peng, Ping-Chiang Lyu and Yuh-Ju * Sun Structural Basis of the Lipid Binding in Rice Nonspecific Lipid Transfer Protein-1 Complexes from Oryza sativa PS50 Jun-Mei Zhou Folding and Chaperone Function of Escherichia coli Trigger Factor PS51 Joseph Wang, Li Xing, Tian-Cheng Li, Naokazu Takeda, Tatsuo Miyamura, Yasuhiro Yasutomi, Darren J. Schofield, Suzanne U. Emerson, Robert H. Purcell,5and R Holland Cheng Role of C-Terminal Peptide in Hepatitis E Virus Capsid Assembly 20 PS52 Sujuan Xu, Hailong Zhang, Lichuan Gu, Yuyan Shu, Shiying Song and Zhengjiong Lin Structures of King Cobra Phospholipase A2 PS53 Chun-Jung Chen, Ming-Yih Liu, Yi-Ting Chen and Jean LeGall Multiple Conformations of Rubredoxin at 0.68 Å Ultrahigh Resolution Reveal Its Electron Transfer Mechanism PS54 Yung-Chang Peng, Jye-Chian Hsiao, Che-Sheng Chung, Ta-Hsien Lin, Wen Chang , and Der-Lii M. Tzou Self-assembly of Vaccinia Viral Fusion Protein A27L Regulates Its Ability to Bind to Cell Surface Haparan Sulfates: Structural and Functional Approach via Site-specific Mutagenesis PS55 Bih-Show, Lou, Ta-Hsien, Lin and Chi-Zen, Lou NMR & Molecular Modeling Study the Conformations of the Inactivated Na+ Channel Gate Peptides Interacted with the Local Anesthetic Diphenyl Drugs PS56 Shoeher Shih,Yih-Ming Weng, and Wenlung Chen Study on the vitamin E protection of lens proteins against lipid peroxidation by FT-Raman spectroscopy PS57 Hsiang-Chee Houng, Shih-Chi Lo, and Woei-Jer Chuang Structural Comparison of Wild-Type and the C192S Mutant of Streptococcal Pyrogenic Exotoxin B PS58 Yu-Chen Liu, Jia-Hau Shiu , Chiu-Yueh Chen, and Woei-Jer Chuang Structure-Function Relationships of RGD-containing proteins in Integrin αIIbβ3, αvβ3, and α5β1 Recognition PS59 Wen-Yih Jeng, Yu-Hong Tsai and Woei-Jer Chuang Expression in E. coli and NMR Characterization of Human Cytochrome c PS60 Ya-Ping Tsao, Kuen-Phon Wu, and Chih-Wei Wu Solution Structure of the Domain III of the Japanese Encephalitis Virus Envelope Protein PS61 Chi-Yuan Chou, Ming-Shi Shiao and Gu-Gang Chang The quaternary structural variance of human apolipoprotein E3 and E4: Size distribution analysis by analytical ultracentrifugation PS62 Yin-Cheng Xie, Ming-Yih Liu, Jean LeGall, Chun-Jung Chen Anaerobic Structure of Ferredoxin II from Desulfovibrio gigas PS63 Chao Sheng Cheng, Dharmaraj Samuel, Yaw Jen Liu, Ku Feng Lin and Ping-Chiang Lyu Binding Mechanism of Non-specific Lipid Transfer Proteins and their role in Plant Defense 21 PS64 Si-han Chen, Min-tasir Wey, Chia-ching Chang, Lou-sing Kan The Effect of pH and Double Helix Association on Pyrimidine Motif Triplex Formation:Thermodynamic and Kinetic Studies PS65 Sulakshana Mukherjee and K.V.R. Chary Calcium Induced Protein Folding: NMR study on a Protozoan Calcium-Binding Protein PS66 Sheree Lee The effect of metal ion in the maintenance of the structure Integrity of malic enzyme PS67 Jen-Yen Huang, Chia-Yu Chang, Tschining Chang and Chun-Jung Chen Crystal Structures of Nucleosie Diphosphate Kinase in Rice PS68 Guoping Wang, Qingsen Yu, Shangwu Ding Structure, antibacterial and antitumor activities of three novel gadolinium complexes containing fluoroquinolones PS69 Li-Chun Huang, Ren-Ting Wang, Mei-Hui Guo2, Shangwu Ding A novel analysis approach to investigating protein dynamics with nuclear magnetic resonance spectroscopy PS70 Hui-Jun Wang, Shangwu Ding Revisit to dissolution of amino acids in water with liquid state NMR spectroscopy PS71 Shun-Liang Tseng, Zhihong Liu, Jian-Ming Chen, Huan-Sheng Huang, Kunta Li, Ming-Yuan Liao, Shangwu Ding Structural basis of membrane-induced cardiotoxin A3 oligomerization Name of author PS72 Y.M. Liou, Ming-Wei Chen Calcium-Dependent Protein-Protein Interactions Induce Changes in Proximity Relationships of Cys-48 and Cys-64 in Chicken Skeletal Troponin I PS73 Masahiro Watanabe, Yoshihiro Kobashigawa, Tomoyasu Aizawa, Makoto Demura, and Katsutoshi Nitta A Non-Native -Helix Is Formed in the -Sheet Region of the Molten Globule State of Canine Milk Lysozyme PS74 Tsang-Lang Lin, U-Ser Jeng, Yuan Hu, Zyun-Hua Huang, and Derek L. Ho SDS Surfactant Influences on the Solution Structures of bata-Amyloid peptide 1-40 PS75 Ying-Jen Shiu, Charlene Su, Kuo Kan Liang, M. Hayashi and S. H. Lin Thermodynamics and Kinetics of Protein Folding in the Mean Field Approximation 22 II. PS76 P. S. T. Leena, T. K. S. Kumar and Chin Yu Elucidation of the three dimensional structure of the chromo-3 sub-domain of the Chloroplast Signal Recognition Particle PS77 Ko-Hsin Chin and Shan-Ho Chou Sheared-type GantiCsyn Base Pair: A Unique d(GXC) Loop Closure Motif Cell & Membrane Biophysics PM01 Chwan-Deng Hsiao, Farhad Forouhar, Wei-Ning Huang, Jyung-Hurng Liu, Kun-Yi Chien, and Wen-guey Wu Structural basis of membrane-induced cardiotoxin A3 oligomerization PM02 Shan-Jen Kuo, Steve S.-F. Yu, Yu-Ju Chen, Hsin-Kai Liao, Sunney I. Chan The Proteolytic Analysis of the pMOB subunit from the Particulate Methane Monooxygenase (pMMO) PM03 Eric Assen B. Kantchev, Shu-fang Cheng, Hung-jen Huang and Ding-kwo Chang Phospholipid Membrane Interaction and Fusion Activity of Two Glutamate-rich Analogues of Influenza Hemagglutinin Fusion Peptide PM04 Wenyuan Gao, Shengli Zhang, Lan Zhang, Haiying Liu, Mingfang Diao, Yinming Zhang An investigation on a cochlea neurotransmitter—glutamate in acoustic trauma PM05 Jun-Mei Zhou Folding and Chaperone Function of Escherichia coli Trigger Factor PM06 Michiki Kasai, Shinya Kobayashi, Hiroyuki Tsukagoshi and Yutaka Kanekawa Permeation of Organic Ions through Calcium Channel in Sarcoplasmic Reticulum Vesicles PM07 Mineyuki Mizuguchi, Shinichi Kamata, Shun-ichiro Kawabata and Keiichi Kawano Conformational Change of Horseshoe Crab Antimicrobial Peptide, Tachyplesin I, in Model Membrane PM08 Taku Tanaka, Yukinori Taniguchi, Seigo Tsuchiya, Tetsuhiko Ohba and Kazuo Ohki Microscopic Imaging of Membrane Physical Properties and Its Applications to Liposomes and Cells PM09 Sing-Yang Chang, Tzu-Ping Ko, Yi-Kai Chen, Po-Huang Liang and Andrew H.-J. Wang Catalytic mechanism revealed by the crystal structure, Identification of the Active Conformation and the Importance of Length of the Flexible Loop 72-83 in Regulating the Conformational Change in Undecaprenyl Pyrophosphate Synthase 23 PM10 Chiu-Yueh Chen, Jia-Hau Shiu, Yi-Chun Chen, Yu-Chen Liu, and Woei-Jer Chaung Determination of the Recognition Sequences of Integrins IIb3, v3, and 51 by Rhodostomin and Its Mutants PM11 Yi-Chun Chen, Chiu-Yueh Chen, Jia-Hau Shiu, Yu-Chen Liu, and Woei-Jer Chaung. Determination of the Recognition Sequences of Integrin 41 by Rhodostomin Mutants PM12 Yu-Hong Tsai, Wen-Yih Jeng ,and Woei-Jer Chuang Identification of the residues of cytochrome c involved in the interaction with Apaf-1 PM13 Yuan-Ping Chu, Chien-Hui Sun, I-Ju Yeh, Pei-Phen Liu and Woei-Jer Chaung Expression and Characterization of the DNA-Binding Domain of FOXP1 Transcription Factor Jing Leng, Hui Chen, Liangbi Li The effect of phosphatidylglycerol on the organization of LHC II trimer PM14 PM15 Dae-Seop Shin and Young-Kee Kim Characterization of a Nonselective Cation Channel Prepared from Tomato Roots PM16 Young-Kee Kim and Kwang-Hyun Cho Effects of Organic Compounds on the Tolaasin-induced Hemolysis PM17 Chunlei Zheng, Ziyang Lin, Yajun Yang, Hanben Niu and Xun Shen Fluorescence Resonance Energy Transfer (FRET) Study on Interaction of Heat Shock Protein hsp27 with p38 MAP kinase in Single Living Cell PM18 Xu Jian-xing A Radical Metabolism as A Partner of Energy Metabolism in Mitochondria PM19 Kuo-Long Lou, Po-Tsang Huang and Yen-Chywan Liaw Molecular Mechanism of Hanatoxin Binding-Modified Gating in Voltage-Gated K+-Channels PM20 Akiko Kashiwagi, Wataru Noumachi, Masato Katsuno, Mohammad T. Alam, Itaru Urabe, Tetsuya Yomo Plasticity of Fitness and Diversification Process During an Experimental Molecular Evolution PM21 Ming-Tao Lee, Fang-Yu Chen and Huey W. Huang Evidence for Membrane Thinning Effect as the Mechanism for Peptide- induced Pore Formation 24 III. Neurobiophysics & Cell Motility PN01 WU Fei-Jian, CHEN Qi-Cai, JEN PHS2 The Role of GABAergic Inhibition in Neural Interactions between Paired Inferior Collicular Neurons of the Big Brown Bat, Eptesicus fuscus PN02 Guey-Shin Wang, Chen-Jei Hong, Tsen-Yann Yen, Hsin-Yi Huang, Yvonne Ou, Wei-Gang Jung, Ting-Yu Kuo, Morgan Sheng, Yi-Ping Hsueh Modification of chromatin structure and transcription by a CASK interacting nucleosome assembly protein PN03 Madoka Suzuki and Shin'ichi Ishiwata Spontaneous oscillatory sliding movement of an actin filament in the A-band motility assay system PN04 Togo Shimozawa and Shin’ichi Ishiwata Functional analysis of F-actin labeled with a fluorescent ATP analogue PN05 Yuta Shimamoto, Madoka Suzuki, Daisuke Sasaki, Kenji Yasuda and Shin’ichi Ishiwata Fluorescence Microscopic Analysis of Spontaneous Oscillatory Contraction (SPOC) in the Contractile System of Muscle PN06 Takashi Nagao Effects of social experience on the development of sexual and aggressive behavior in male crickets IV. Biophysical Technology V. PB01 Min-Tasir Wey and Lou-Sing Kan Study of DNA triplex formation with two non-pyrimidine-purine-pyrimidine base triads in a Sept-decamer 5’-TTCTTCTGATTCCTCC in Aqueous Solution PB02 Shu-Wen Teng, Chang-Chun Lee, Hsiao-Ching Chen, Hsuan-Shu Lee, Chen-Yuan Dong A Two-photon , Biomechanical Manipulation Platform for Tissue Engineering Studies PB03 Ya-Wen Feng, Chiu-Ming Wang and Hsiu-An Chu Ammonia-induced Structural Changes of the Oxygen-Evolving Complex in Photosystem II as Revealed by Light-Induced FTIR Difference Spectroscopy Computational Biophysics PC01 Vitaliy Y. Gorbatyuk, Cheng-Kun Tsai, Chi-Fon Chang and Tai-huang Huang Solution Structure and Dynamics of Onconases with N-terminal and Met23 Mutations 25 PC02 C. Satheesan Babu, Todor Dudev, R. Casareno, J. A. Cowan, and Carmay Lim A Combined Experimental and Theoretical Study of Divalent Metal Ion Selectivity and Function in Proteins: Application to E. coli Ribonuclease H1 PC03 Yen-lin Lin and Carmay Lim A DFT/CDM Study of the Factors Governing the Protonation State of Zn-bound Histidine in Proteins PC04 Tammy Man-Kuang Cheng and Carmay Lim A method to predict ligand-binding sites from protein sequences PC05 Todor Dudev and Carmay Lim Monodentate vs. Bidentate Carboxylate Binding in Magnesium and Calcium Proteins: What are the Basic Principles? PC06 Jie-Oh Lee Crystal Structure of the BAFF and BAFF-R Complex: Implications for the Receptor Activiation PC07 Hiroshi Nakashima, Kaoru Kido and Ken Nishikawa DNA and proteins are simultaneously stabilized in thermophilic species PC08 Hui-Hsuan Tu, Jung-Hsin Lin AcrB Multidrug Transport Mechanisms in a POPC Bilayer Explored by Molecular Dynamics Simulations. PC09 Fang-Yu Su, Jung-Hsin Lin A Hierarchical Virtual Screening of Farnesyl Transferase Inhibitors Based on Structure Analysis PC10 Ajay Chaudhari, Prabhat K. Sahu, Shyi-Long Lee Computational study of amino acid-water interaction through Density Functional Theory method PC11 Shawn Shih Applications of a 3-D Unpaired Electron Spin Density Equation for Methyl group in Radiolysis and Biophysics PC12 Ru-Ting Yang, Hsueh-Fen Juan, and Ming-Syan Chen Using Discretization Techniques to Discover Gene Patterns for Diagnostics VI. Imaging & Single Molecules PI01 Elena Perevedentseva, Fu-Jen Kao Autofluorescence from the PC12 cells as a response to excitation of near-infrared femtocecond laser PI02 Wen Lo, Tso Chien-Hsin, Sun-Jan Lin, Shiou-Hwa Jee, Chen-Yuan Dong 26 Monitoring Transdermal Delivery of Quantum Dots Using Multiphoton Fluorescence Microscopy PI03 Tsung-Kai Chiu, Chin-Kuan Tung, Wen Lo, Sun-Jan Lin, Shiou-Hwa Jee, Chen-Yuan Dong Characterizing the Effects of Spherical Aberration and Scattering on Multi-Photon Image Formation PI04 Kuniaki Nagayama, Tomoharu Matsumoto, Yuji Hara and Yasuo Mori Electron Microscopic Single Particle Analysis with a Calcium Channel PI05 Keiichi Kinowaki, Silvia Iskandar, Tadashi Tojo, Daisuke Aoki, Hisashi Tadakuma, Takashi Funatsu Single molecule imaging reveals oligomerization of chemoattractant receptors PI01 PI06 Yen Sun, Wen Lo, Jiun-Wen Su, Sun-Jan Lin, Shion-Hwa Jee, Chen-Yuan Dong Applying Two-Photon Polarization Microscopy in the Imaging of Skin's Epidermal and Dermal Layers PI07 Kuniaki Nagayama, Radostion Danev and Tadao Tsuruta Schlieren Shutter Phase Retrieval for Strong Objects in Transmission Electron Microscopy: Theory and Simulation PI08 Kai-Chao Yu, Guoping Wang, Shangwu Ding The high resolution NMR investigation of typical MRI contrast agents: possible significance to nanoscale magnetic resonance imaging PI09 Shangwu Ding, Lian-Pin Hwang A denoising technique for nanoscale magnetic resonance imaging PI10 Shangwu Ding, Wen-Yan Liang, Zhen Wu, Li-Chiang Chen,Yan-Chi Chen Design of RF and gradient field microcoils for nanoscale magnetic resonance imaging 27