Table of contents The Epidemiology of Osteosarcoma.- The Etiology of Osteosarcoma.- Imaging Assessment of Osteosarcoma in Childhood and Adolescence.- Conditions Mimicking Osteosarcoma.- Surgical Management of Primary Osteosarcoma.- Osteosarcoma Multidisciplinary Approach to the Management from the Pathologist's Perspective.The Role of Radiotherapy in Osteosarcoma.- Osteosarcoma Lung Metastases Detection and Principles of Multimodal Therapy.- Surgical Treatment of Pulmonary Metastases from Osteosarcoma in Pediatric and Adolescent Patients.- Non-Surgical Treatment of Pulmonary and Exra-pulmonary Metastases.- Adjuvant Chemotherapy in Osteosarcoma.- Osteosarcoma: Review of the Past, Impact on the Future: The American Experiences.- Osteosarcoma: The European Osteosarcoma Intergroup (EOI) Perspective.- The Treatment of Non-Metastatic High Grade Osteosarcoma of the Extremity: Review of the Italian Rizzoli Experience: Impact on the Future.Osteosarcoma: The Coss Experience.- Treatment of Osteosarcoma: The Scandinavian Sarcoma Group Experience.- Childhood Osteosarcoma.- International Collaboration is Feasible in Trials for Rare Conditions: The EURAMOS Experience.- Pediatric and Adult Osteosarcoma: Comparisons and Contrasts in Presentation and Therapy.- The Role of Physical Therapy and Occupational Therapy in the Rehabilitation of Pediatric and Adolescent Patients with Osteosarcoma.- Caring for Children and Adolescents with Osteosarcoma.- Prosthetics for Pediatric and Adolescent Amputees.- Functional, Psychosocial and Professional Outcomes in Long-Term Survivors of LowerExtremity Osteosarcomas: Amputation Versus Limb Salvage.- Bridging the Gap between Experimental Animals and Humans in Osteosarcoma.- Is There a Role for Immunotherapy in Osteosarcoma?- Molecular Classification of Osteosarcoma.Current Concepts on the Molecular Biology of Osteosarcoma.- How the NOTCH Pathway Contributes to the Ability of Osteosarcoma Cells to Metastasize.- The Role of Fas/FasL in the Metastatic Potential of Osteosarcoma and Targeting this Pathway for the Treatment of Osteosarcoma Lung Metastases.- Bone Marrow Micrometastases Studied by an Immunomagnetic Isolation Procedure in Extremity Localized Nonmetastatic Osteosarcoma Patients.- Strategies to Explore New Approaches in the Investigation and Treatment of Osteosarcoma.- History of Orthopaedic Oncology in the USA.- Editorial Summation.- Index.