PERSONAL DETAILS:
Dr. Leonid I. Brodsky, male, 10.8.1946, Israeli
address:
Chouchit Str. 11, apt.2, Zichron Yaacov, 30900, Israel
phone:
972-4-845-0766(home); 972-4-828-8329(off), 972-528-374702(cell);
email:
lbrodsky@reserch.haifa.ac.il; mbrodsky@actcom.co.il
EDUCATION:
1970 M.Sc. in Mathematics and Programming, Moscow Pedagogical University, Faculty of
Mathematics, Moscow, Russia
2007 Ph.D. (summa cum laude) Computational and Evolutionary Biology, University of
Haifa, Haifa, Israel
WORK/RESEARCH EXPERIENCE:
2012 – present, Director, Tauber Bioinformatics Research Center; Senior Lecturer,
Department of Evolutionary and Environmental Biology, University of Haifa, Israel,
NGS and omics data analysis; whole genome regulation; data integration and modeling
2008 – 2011, Scientist; Institute of Evolution of the University of Haifa, Laboratory of
Systems Biology and Data Mining, Head: Analysis of microarrays and NGS data; whole
genome regulation; data integration and modeling
2004 – 2008, Tel Aviv University, Israel, Researcher: Analysis of 3D structures, analysis of
microarray experiments, genome assembly algorithms and genome bioinformatics
1998 – 2004, Quark Biotech Inc. Nes-Ziona, Israel, Senior Scientist: Small molecules
and pharamacophor reconstruction; analysis of high throughput screenings of small
molecules (HTS); analysis of microarray experiments; sequence analysis;
1988 – 1998, Moscow State University, Moscow, Russia, Group leader : Development of
the GeneBee server (http://www.genebee.msu.su) for sequence and 3D-structure analysis.
1971 – 1988, A.N. Kolmogorov Interdepartamental Laboratory of Statistical Methods,
Moscow State University, Moscow, Russia, Researcher: Research and teaching in the
field of mathematical statistics
PROFESSIONAL ACTIVITIES
o EU COST Action “Statistics of plant genomes”, in Management Committee (2009-2012)
o Teaching the “Systems Biology” and “Analysis of high-throughput data” courses in 20092014 for MSc bioinformatics students, University of Haifa
o Consultant, Weizmann Institute of Science, Israel, 2008 – 2011: Computational
metabolomics and NGS data analysis; data integration
o Consultant, Cleveland BioLabs Inc. Buffalo, NY, USA, 2005-2008: Analysis of
microarrays and bioassay screenings; computational chemistry; mathematical statistics
o Head of Russian EMBnet Node: European Organization of Biocomputing (1996-1998)
PUBLICATIONS (selected from a total of 48 peer reviewed articles and 4 book chapters)
 Brodsky L, Kogan S, BenJacob E, Nevo E (2010) An application of a binary search
algorithm to analysis of whole genome data, PNAS, 107(39): 16893-16898
 Brodsky L, Moussaieff A, Shahaf N, Aharoni A, and Rogachev I (2010) Evaluation of
peak picking quality in LC-MS metabolomics data, Analytical Chemistry, 82(22):91779187
 Gasparian A, Burkhart A, Purmal A, Brodsky L, Pal M, Saranadasa M, Bosykh D,
Commane M, Guryanova O, Pal S, Safina A, Sviridov S, Koman I, Komar A, Gudkov
A, Gurova K. (2011) Curaxins: Anticancer Compounds that Simultaneously Suppress
NF-kB and Activate p53 through depletion of functional “Facilitate Chromatin
Transcription” (FACT) Complex, Science Translational Medicine, 3:(95): 95ra74
 Leonova KI, Brodsky L, Lipchick B, Pal M, Novototskaya L, Chenchik AA, Sen GC,
Komarova EA and Gudkov AV (2013) p53 cooperates with DNA methylation and a
suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs, PNAS, 110:22-23
 A. Acevedo, L. Brodsky, R. Andino (2013) Mutational and fitness landscapes of an
RNA virus revealed by highly accurate population sequencing, Nature,
30;505(7485):686-90. doi: 10.1038/nature12861
PATENTS
Tucker J., Sviridov S., Brodsky L., Burkhart C., Purmal A., Gurova K., Gudkov A. USA
patent, Patent Application No. 13/121,051, Reference No.: 31727/43271A US, 2011.
Carbazole compounds and therapeutic uses of the compounds.