References 1. Baekelandt V., DeStrooper B., Nuttin B., Debyser Z. 2000. Gene therapeutic strategies for neurodegenerative diseases. Current Opinion in Molecular Therapeutics 2:540-554. 2. Bunnell B & Morgan RA. 1998. Gene therapy for infectious deceases. Clinical Microbiology Reviews 11:42-56. 3. Decker T., Muller Mathias., Stockinger Silvia. 2005. The yin and yang of type I interferon activity in bacterial infection. Nature Reviews Immunology 5:675-687. 4. Isner, J.M. Myocardial gene therapy. 2002. Nature 415, 234-239. 5. Marshall E. 1999. Clinical Trials- Gene therapy death prompts review of adenovirus vector. Science 286:2244-2245. 6. McCaffrey AP., Fawcett., Nakai H., McCaffrey L., Ehrhardt A., Pham T., Pandy K., Xu H., Feuss S., Storm T., Kay MA. 2008. The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver. Molecular Therapy 16(5):931-941. 7. Nusionzon I & Horvath CM. 2006. Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Molecular and Cellular Biology 26(8):3106-3113. 8. Thomas CE., Ehrhardt A., Kay MA. 2003. Progress and problems with the use of viral vectors for gene therapy. Nature Reviews Genetics 4:346-358. 9. Tseng JF & Mulligan RC. 2002. Gene therapy for pancreatic cancer. Surgical Oncology Clinics of North America 11(3):537-569. 10. Wolkowicz R., Nolan GP. 2005. Gene therapy progress and prospects: Novel gene therapy approaches for AIDS. Gene Therapy 12: 467-476. 11. Muruve DA. 2004. The Innate Immune Response to Adenovirus Vectors. Human Gene Therapy 15(12): 1157-1166. 12. Nociari M., Ocheretina O., Schoggins JW., Falck-Pedersen E. 2007. Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator. Journal of Virology 81(8): 4145-4157. 13. Nusinzon I., Horvath. 2003. Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. PNAS 100(25): 14742-14747. 14. Hartman ZC., Kiang A., Everett RS., Serra D., Yang XY., Clay TM., Amalfitano A. 2007. Adenovirus infection triggers a rapid myD88-regulated transcriptome response cirtical to acute phase and adaptive immune responses in vivo. Journal of Virology 81(4): 1796-1812. 15. Nusinzon I., Horvath CM. 2005. Unexpected roles for deacetylation in interferon- and cytokine – induced transcription. Journal of Interferon and Cytokine Research 25:745-748. 16. Akira Shizuo. 2003. Toll-like Receptor Signaling. The Journal of Biological Chemistry 278(40):38015-38108. 17. Muruve DA., Petrilli V., Zaiss AK., White LR., Clark SA., Ross PJ,. Parks RJ., Tschopp J. 2008. The inflammasome recognizes cytosolic microbial and host DNA and triggers and innate immune response. Nature 452: 103-107. 18. Dorn A., Zhao H., Granberg F., Hosel M., Webb D., Sevensson C., Pettersson U., Doerfler W. 2005. Identification of specific cellular genes up-regulated late in adenovirus type 12 infection. Journal of Virology 79(4):2404-2412.