CURRICULUM VITAE
Fung-Lung Chung, Ph.D.
PERSONAL
INFORMATION:
EDUCATION:
Home Address:
302 Oak Knoll Ter.
Rockville, MD 20850
(301)315-2666
Office Address:
Department of Oncology
Lombardi Comprehensive Cancer Center
Georgetown University Medical Center
3800 Reservoir Road, NW
Washington, DC 20057-1465
Phone: (202)687-3021
Fax: (202)687-1068
Undergraduate:
Chung-Yuan College of Sciences &
Engineering
Chung-Li, Taiwan
1968 - 1971
B.S., Bio-organic Chemistry
Graduate Education: University of Utah
Medicinal Chemistry
Salt Lake City, Utah
1973 - 1978
Ph.D., Medicinal Chemistry
PROFESSIONAL
EXPERIENCE
Fellowship:
Columbia University
Comprehensive Cancer Center
New York, NY
Staff Associate, 1979 - 1980
Postdoctoral Fellow, 1978 - 1979
Date(s) of Service:
Title:
Institution:
Address:
2008 - 2011
Co-leader, Cancer Risk Program
LCCC, Georgetown University
Washington, DC
Date(s) of Service:
Title:
2004 - Present
Tenured Professor
(The Martha and Edward
Institution:
LCCC and Departments of Oncology and
Biochemistry and Molecular and Cellular
Biology
Washington, DC
Haddad and the E.H. Winkler Professor)
Address:
Date(s) of Service:
Title:
Institution:
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Institution:
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Address:
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Title:
HONORS and
AWARDS
2010 Spring semester
Visiting Professor
National University of Singapore
Singapore
1996 - 2004
Program Leader:
Mechanisms of Carcinogenesis and
Chemoprevention
Institute for Cancer Prevention (IFCP)
(NCI-designated, formerly American Health
Foundation Cancer Center)
Valhalla, NY
1995 - 2004
Chief, Division of Carcinogenesis &
Molecular Epidemiology
Institute for Cancer Prevention (IFCP)
(NCI-designated, formerly American Health
Foundation Cancer Center)
Valhalla, NY
Institution:
Address:
1990 - 1995
Associate Chief
Division of Chemical Carcinogenesis
American Health Foundation
Valhalla, NY
Date(s) of Service:
Title:
Institution:
Address:
1985 - 1995
Head, Section of Nucleic Acid Chemistry
American Health Foundation
Valhalla, NY
Date(s) of Service:
Title:
Institution:
Address:
1981 - 1984
Associate Research Scientist
American Health Foundation
Valhalla, NY
Date(s) of Service:
Title:
Institution:
Address:
1993 - 2001
Adjunct Associate Member
Memorial Sloan-Kettering Cancer Center
New York, NY
Date(s) of Service:
Title:
Institution:
Address:
1992 - 2004
Adjunct Professor
New York Medical College
Valhalla, NY
Date:
Honor:
2010 - Present
Editorial Board Member
Institution/Organization:
ISRN Pulmonology
Date:
Honor:
Institution/Organization:
2008 - Present
Editorial Board Member
Lung Cancer: Targets and Therapy
Date:
Honor:
Institution/Organization:
2003 - 2012
Editorial Board Member
Molecular Nutrition & Food Research
Date:
Honor:
Institution/Organization:
2008
Session Chair
International Symposium on Novel
Strategies and Targeted Prevention
and Treatment of Cancer, New Delhi,
India
Date:
Honor:
Institution/Organization:
2006
Scientific Advisor
Tea Council of the USA, NYC, NY
Date:
Honor:
Institution/Organization:
2004
Chair
AACR Program Committee on
Chemical Carcinogenesis, Orlando,
FL
Date:
Honor:
2003
Organizer and Co-Chair of the
Symposium on Chemistry and
Mechanisms of Tea in Disease
Prevention
226th American Chemical Society
National Meeting in New York City
Institution/Organization:
Date:
Honor:
Institution/Organization:
2001
Organizer and Chair of the
Symposium on DNA and Protein
Modifications by Aldehydic
Compounds from Lipid Peroxidation
222nd American Chemical
Society National Meeting in Chicago.
Date:
Honor:
Institution/Organization:
1999
Featured on the cover
Cancer Research, Vol. 59, July1
Date:
Honor:
1997
Editorial Board Member
Institution/Organization:
Journal of Cellular Biochemistry,
Chemoprevention Supplements
Date:
Honor:
Institution/Organization:
Date:
Honor:
1994 - 1997
Editorial Board Member
Chemical Research in Toxicology
1996
Chair of the Poster Discussion
Session on Oxygen Radicals
AACR Annual Meeting in
Washington, DC.
Institution/Organization:
Date:
Honor:
Institution/Organization:
Date:
Honor:
Institution/Organization:
1993 - 1995
Editorial Board Member
Oncology Reports, an International
Journal
Date:
Honor:
1992
Chair of the Poster Discussion
Session on Dietary
Carcinogenesis/Chemoprevention
AACR Annual Meeting in San Diego,
CA.
Institution/Organization:
Date:
Honor:
Institution/Organization:
Date:
Honor:
Institution/Organization:
PROFESSIONAL
SOCIETIES:
1995
Chair of the Session on Chemical
Carcinogenesis and Cancer
Prevention
6th SCBA International Symposium,
Vancouver, B.C.
1990
Chair of the Mini-Symposium on
Detection of DNA Adduct
AACR Annual Meeting in
Washington, DC.
1982
Young Investigator Award
NCI
Date:
Society:
1986 - Present
American Association for the Advancement of
Science
Date:
Society:
1983 - Present
American Association for Cancer Research
Date:
1978 - Present
Society:
PUBLIC SERVICE
American Chemical Society
Role/Status:
Organization:
Date(s) of Service:
Regular member
The NCI PREVENT Program Review
Committee
2012 – Present
Role/Status:
Organization:
Date(s) of Service:
Review Committee Member
NIH Program Project Special Panel IV
2011- Present
Role/Status:
Organization:
Date(s) of Service:
Regular Review Committee Member
ACS Scientific Review Committee
2007 – 2012
Role/Status:
NIH Scientific Review Committee Ad Hoc
member
Chemo- and Dietary Prevention Study
Section, Division of Research Grants.
2003 - Present
Organization:
Date(s) of Service:
Role/Status:
Organization:
Date(s) of Service:
Role/Status:
NIH Review Committee Ad Hoc member
Program Projects and Cancer Center Support
Grants.
1990 - Present
Date(s) of Service:
Program Leader, Mechanisms of
Carcinogenesis Program
AHF Cancer Center Grant from the NCI
(rated as an outstanding program).
1996 - 2004
Role/Status:
Organization:
Date(s) of Service:
Senior Advisory Committee
American Health Foundation (IFCP)
1992 - 2004
Role/Status:
Organization:
Ad Hoc Member
American Cancer Society Scientific Review
Committee
1990 - 2004
Organization:
Date(s) of Service:
Role/Status:
Date(s) of Service:
Consultant of IARC handbook on Cancer
Prevention, vol. 9: Cruciferous Vegetables,
Isothiocyanates and Indoles.
International Agency for Research on
Cancer, World Health Organization.
2003
Role/Status:
Member
Organization:
Organization:
Date(s) of Service:
AACR Program Committee, Washington,
DC
2003
Role/Status:
Organization:
Date(s) of Service:
Member
NCI Lung Cancer Progress Review Group
2001
Role/Status:
Member of Chemical Pathology Study
Section
NIH Scientific Review Committee
1990 - 1994
Organization:
Date(s) of Service:
INVITED LECTURES:
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Institution/Society Name:
Tubulin and mutant p53 as potential
targets of chemopreventive ITCs
School of Environmental Medicine
New York University Medical School
3/22/2013
Molecular targets of isothiocyanates
as cancer chemopreventive agents
Ground Rounds at the Cancer
Institute of New Jersey, Rutgers
University
9/21/ 2011
Mechanisms of cancer prevention by
isothiocyanates: From animals to
humans
Grand Rounds at the Kimmel Cancer
Center of Thomas Jefferson
University, Philadelphia, PA
10/20/2010
Cyclic DNA adducts: Formation and
possible roles in human cancers
American Chemical Society 239th
National Meeting, Symposium on
Reactive Carbonyl Species and their
Health Consequences, San Francisco,
CA
3/21/2010
Cancer prevention by cruciferous
vegetables derived ITCs: From lab
to human
International Symposium on Herbal
Medicines and Vaccines for Cancer
Therapy, Academia Sinica, Taipei,
Date of Presentation:
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Taiwan
12/2/2009
Mechanisms of cancer prevention by
ITC’s
Department of Pharmacology and
Biochemistry, Penn State University,
Hershey, PA
11/16/2009
Lung cancer chemoprevention by
ITCs: A mechanisms study
The 12th SCBA International
Symposium, Academia Sinica,
Taipei, Taiwan
6/2009
Lung cancer prevention by ITCs
Uniformed Services University of
Health Sciences, Armed Forces
Radiobiology Research Institute
5/2009
Cancer prevention by dietary ITCs:
From mechanisms to humans
International Conference on Cancer
Prevention by Foods and Chemicals:
Basic and Clinical Research. Taipei,
Taiwan
4/2009
Cruciferous vegetable-derived
isothiocyanates covalently bound to
tubulin: A mechanism of cell
growth and apoptosis
International Symposium on Novel
Strategies for targeted Prevention and
Treatment of Cancer, New Delhi,
India
12/2008
Selective depletion of mutant p53 by
ITCs as a potential mechanism for
their chemopreventive activities
Biochemistry and Biophysics Center,
DIR/NHLBI/NIH, Laboratory of
Molecular Biophysics, Bethesda, MD
10/2008
Title of Presentation:
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Institution/Society Name:
Date of Presentation:
Mechanisms of prevention of oral
cancer in smokers: A clinical
investigation
The 9th International Conference on
Mechanisms of Antimutagenesis and
Anticarcinogenesis, Jeju Island,
Korea
12/2007
Covalent binging to tubulin: A
mechanism of cell growth arrest
and apoptosis by isothiocyanates
Symposium on Cancer
Chemoprevention, the 12th World
Congress on Advances in Oncology,
Crete, Greece
10/2007
Phytochemicals in Cancer Prevention
Shanghai Cancer Institute, Shanghai,
China
4/2007
Mechanism based chemoprevention
of lung cancer by isothiocyanates:
studies from animals to humans
M.D. Anderson Cancer Center,
Houston, TX
1/2007
Chemoprevention of tobacco-induced
carcinogenesis
University of Kentucky, Department
of Pharmacology and Toxicology,
Knoxville, KY
11/2006
Tea in lung cancer prevention:
studies from animals to humans
Taiwanese American Science of
Technology Association (TASTA),
Bethesda, MD
6/2006
Recent progress on tea and cancer
research
Tea Council of America, New York,
NY
2/2006
Title of Presentation:
Institution/Society Name:
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UNIVERSITY
SERVICE:
Polyphenols as antioxidants
American Chemical Society National
Meeting in Washington, DC
8/2005
Tea as a cancer chemopreventive
agent
Tea Expo on “Take me to Tea.”
Symposium on Tea and Health,
Providence, RI
12/2004
Chemoprevention of lung cancer by
isothiocyanates
Fred Hutching Cancer Center, Seattle,
WA
9/2003
Green tea and cancer prevention:
Studies in animals and humans
Chemistry and Mechanism of Tea in
Disease Prevention, ACS national
meeting, New York, NY
8/2003
Department
Role/Function:
Committee Name:
Date(s) of Service:
Member
Cancer Center Shared Resources Committees
2010 - Present
Role/Function:
Committee Name:
Date(s) of Service:
Member
Tumor Biology Oversight Committee
2006 - Present
Role/Function:
Committee Name:
Member
Georgetown University Animal Care and
Use Committee (GUACUC)
2005 - 2007
Date(s) of Service:
TEACHING
ACTIVITIES:
Tea and cancer prevention
Symposium of Agricultural and Food
Chemistry Award to Dr. C.T. Ho.
The 230th ACS National Meeting,
Washington, DC
8/2005
Name and Course Number:
Topics in Molecular Epidemiology
TBIO 581
Role:
Course Director and Lecturer
Number of Direct Contact Hours:
16
Year Taught:
2004 - present
Number of Students:
6 - 10
Overall Evaluation Score:
4-5/5
Name and Course Number:
Cellular and Molecular Aspects of
Transformed Cells, TBIO 508
Role:
Carcinogenesis Section Course
Director and Lecturer
Number of Direct Contact Hours:
24
Year Taught:
2004 - 2009
Number of Students:
15 - 20
Overall Evaluation Score:
4-5/5
Name and Course Number:
Molecular Basis of Carcinogenesis,
BCHB 540/RASC 540
Role:
Lecturer
Number of Direct Contact Hours:
20
Year Taught:
2006 - present
Number of Students:
12 - 18
Overall Evaluation Score:
4-5/5
Name and Course Number:
Cancer Control and Prevention,
TBIO 540
Role:
Lecturer
Number of Direct Contact Hours:
16
Year Taught:
2007 - present
Number of Students:
8 - 10
Overall Evaluation Score:
4-5/5
COLLABORATIVE
ACTIVITIES:
Mentoring
Name of Mentee:
Kamal Datta (Research Assistant Professor)
Dates of Mentorship: August 2010 - present
Outcomes:
Dr. Datta has submitted grants to NIH, but
has not been approved for funding.
Name of Mentee:
Ling Zheng (Assistant Professor)
Dates of Mentorship: May 2008 - present
Outcomes:
Tenured associate professor
Name of Mentee:
Anthony DiPasqua (Postdoctoral Fellow)
Dates of Mentorship: August 2008 – April 2011
Outcome:
Tenure-track assistant professor
Name of mentee:
Lixin Mi (Postdoctoral Fellow)
Dates of Mentorship: August 2004 - March 2011
Outcome:
Research assistant professor
Joint Publications
Wang, X., Di Pasqua, A. J., Govind, S., McCracken, E., Hong, C.,
Mi, L., Mao, Y., Wu, J., Tomita, Y., Woodrick, J. C., Fine, R.,
Chung, F.-L., Selective depletion of mutant p53 by cancer
chemopreventive isothiocyanates and its structure-activity
relationships. J. Medicinal Chem., 54(3), 809-816, 2011.
Dyba, M., Wang, A., Noone, A-M., Goerlitz, D., Shields, Zheng,
Y.-L., Rivlin, R., Chung, F.-L. Metabolism of isothiocyanates in
individuals with positive and null GSTT1 and M1 genotypes after
drinking watercress juice. Clin. Nutr., 29(6), 813-8, 2010.
Pan, J., Keffer, J., Emami, A., Ma, X., Lan, R., Goldman, R.,
Chung, F.-L. Formation of acrolein-derived DNA adduct in human
colon cells: its role in apoptosis induction by docosahexaenoic acid.
Chem. Res. Toxicol., 22, 798-806, 2009.
Mi, L., Gan, N., Cheema, A., Dakshanamurthy, S., Yang, D. C. H.,
Chung, F.-L. Cancer preventive isothiocyanates induce selective
degradation of cellular α- and β-tubulins by proteasomes. J. Biol.
Chem., 284, 17039-17051, 2009.
Kang, H.J., Hong, Y.B., Kim, H.J., Rodriguez, O.C., Nath, R.G.,
Tilli, E.M., Albanese, C., Chung, F.L., Kwon, S.H., Bae, I.
Detoxification: a novel function of BRCA1 in tumor suppression?
Toxicol Sci., 122(1), 26-37, 2011.
RESEARCH GRANTS
SCHOLARSHIP AND
RESEARCH:
Current Active
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project:
Percent Effort:
Total Dollar Amount:
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
NIH/NCI
RO1-CA-100083-7
Mechanisms of Chemoprevention
by Isothiocyanates
6/22/10-1/31/2015
Principal Investigator
25%
$1,160,309
NIH/NCI
RO1-CA-113449-5
Prevention of Oral Cancer in
Smokers by Tea: A Mechanism
Study
3/16/2006-1/31/2012
Role on Project:
Percent Effort:
Total Dollar Amount:
Principal Investigator
20%
$1,051,442
Agency:
Identifying Number:
Title of Project:
NIH/NCI
RO1-CA-134892-2
Lipid Peroxidation-Derived Cyclic
Adducts in Hepatocarcinogenesis
8/1/2009-5/31/2014
Principal Investigator
20%
$1,855,606
Dates of Project Period:
Role on Project:
Percent Effort:
Total Dollar Amount:
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project:
Percent Effort:
Total Dollar Amount:
Current Pending
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project:
Percent Effort:
Total Dollar Amount:
Score:
Previous (Since 1982)
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project:
Agency:
Identifying Number:
Title of Project:
NIH/NCI
P30 CA51008-18 (PI: Weiner)
Cancer Center Support Grant
9/6/2010-4/6/2013
Co-Leader
5%
NIH/NCI
RO1-CA-43159-24
Enals in Tumorigenesis
7/1/2012-5/31/2017
(Renew in progress)
Principal Investigator
20%
$1,370,526
NCI
RO13
Chemistry and Mechanisms of
Tea in Disease Prevention
2003-2004
Principal Investigator
Dates of Project Period:
Role on Project:
NCI
RO13
Modification of Proteins and DNA by
aldehydes from lipid peroxidation
2001-2002
Principal Investigator
Agency:
Identifying Number:
HEI
Research Agreement #98-2
Title of Project:
Dates of Project Period:
Role on Project:
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project:
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project:
Agency:
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Title of Project:
Dates of Project Period:
Role on Project:
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project:
Agency:
Identifying Number:
Title of Project:
DNA Biomarkers for Auto
Mechanics Exposed to Aldehydes
1999-2001
Principal Investigator
Tea Trade Health Research
Associates
NA
Tea and Tobacco Carcinogenesis
1994-1997 & 1998-2001
Principal Investigator
NCI, Chemoprevention Branch,
DCPC
NO1-CN-85095-08
Chemoprevention of Lung Cancer in
Strain A Mice
1992-1995
Principal Investigator
NCI, Chemoprevention Branch,
DCPC
NO1-CN-85095-06
Chemoprevention of TobaccoSpecific Nitrosamine-Induced Lung
Tumors in Rats With Substituted
Isothiocyanates
1991-1995
Principal Investigator
NCI
RO1 - CA-51830
Endogenous Enals in Nitrosamine
Carcinogenesis
1990-1993
Principal Investigator
Dates of Project Period:
Role on Project:
NCI
PO1 - CA-46535
Isothiocyanates and Nitrosamine
Carcinogenesis; Project 1: StructureActivity Relationships for Inhibition
1987-2002
Project Leader of Project 1
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
NCI
RO1 - CA-43159
Enals in Tumorigenesis
1986-2005
Role on Project:
Principal Investigator
Agency:
Identifying Number:
Title of Project:
NCI
RO1 - CA-41544
Glucosinolates and Environmental
Nitrosamine Activation
1986-1989
Principal Investigator
Dates of Project Period:
Role on Project:
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project:
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project:
Agency:
Identifying Number:
Title of Project:
Dates of Project Period:
Role on Project
NCI
RO1 - CA-23901
Environmental Nitrosamines –
Metabolism and Carcinogenesis
1980-1987
Co-Investigator
AICR
Sinigrin as Anticarcinogen to
Nitrosamines
1984-1986
Principal Investigator
NCI
R23-CA-32271
Screening for Inhibitors of NNitrosamine Carcinogenesis
1982-1985
Principal Investigator
PUBLICATIONS
Original Papers in Refereed Journals
1.
Chung, F.-L., Schram, K.H., Panzica, R.P., Earl, R.A.,
Wotring, L.L., Townsend, L.B. Synthesis of certain [6:5:6]
linear tricyclic nucleosides as potential antitumor agents.
Journal of Medicinal Chemistry, 23, 1158-1166, 1980.
2.
Chung, F.-L., Earl, R.A., Townsend, L.B. Reductive
debromination of some purine and purine-like nucleosides.
Journal of Organic Chemistry, 45, 4056-4057, 1980.
3.
Chung, F.-L., Earl, R.A., Townsend, L.B. Synthesis of 5amino-9-(-D-ribofuranosyl)-v-triazino[4,5-b]-pyrimido[4,5d])pyrrol-4-one and unusual ring opening of this new ring
system with the Vilsmeier-Haack reagent. Journal of Organic
Chemistry, 45, 2532-2535, 1980.
4.
Chung, F.-L., Earl, R.A., Townsend, L.B. The novel synthesis
of a [6:5:6] linear isoguanosine type tricyclic nucleoside using
carbonyl sulfide. Tetrahedron Letters, 21, 1599-1602, 1980.
5.
Hernandez, M.A., Chung, F.-L., Earl, R.A., Townsend, L.B. A
general route for the facile synthesis of 4-thioxopyrimidin-2one derivatives via the annulation of cyclic o-aminonitriles
using carbonyl sulfide. Journal of Organic Chemistry, 46,
3941-3945, 1981.
6.
Chung, F.-L., Hecht, S.S. Formation of cyclic 1,N2-adducts by
reaction of deoxyguanosine with -acetoxy-Nnitrosopyrrolidine,4-(carbethoxynitrosamino) butanal, and
crotonaldehyde. Cancer Research, 43, 1230-1235, 1983.
7.
Chung, F.-L., Young, R., Hecht, S.S. Formation of cyclic 1,N2propanodeoxyguanosine adducts in DNA upon reaction with
acrolein or crotonaldehyde. Cancer Research, 44, 990-995,
1984.
8.
Chung, F.-L., Juchatz, A., Vitarius, J., Hecht, S.S. Effects of
dietary compounds on -hydroxylation of N-nitrosopyrrolidine
and N'-nitrosonornicotine in rat target tissues. Cancer
Research, 44, 2924-2928, 1984.
9.
Kochevar, I.E., Chung, F.-L., Jeffrey, A.M. Photoaddition of
chlorpromazine to DNA. Chemico Biological Interactions,
51, 273-284, 1984.
10. Chung, F.-L., Wang, M., Hecht, S.S. Effects of dietary indoles
and isothiocyanates on N-nitrosodimethylamine and 4(methylnitrosamino)-1-(3-pyridyl)-1-butanone -hydroxylation
and DNA methylation in rat liver. Carcinogenesis, 6, 539-543,
1985.
11. Chung, F.-L., Hecht, S.S. Formation of the cyclic 1,N2-glyoxaldeoxyguanosine adduct upon reaction of N-nitroso-2hydroxymorpholine with deoxyguanosine. Carcinogenesis, 6,
1671-1673, 1985.
12. Chung, F.-L., Tanaka, T., Hecht, S.S. Induction of liver tumors
in F344 rats by crotonaldehyde. Cancer Research, 46, 12851289, 1986.
13. Chung, F.-L., Wang, M., Carmella, S.G., Hecht, S.S. Effects of
butylated hydroxyanisole on the tumorigenicity and
metabolism of N-nitrosodimethylamine and Nnitrosopyrrolidine in A/J mice. Cancer Research, 46, 165-168,
1986.
14. Palladino, G.F., Chung, F.-L., Hecht, S.S. 3-(2-Deoxy--Derythropentofuranosyl)-6,7-dihydro-6,7-dihydroxyimidazo[1,2a]purin-9(3H)one, a major deoxyguanosine adduct formed
from a novel diazohydroxide product of -hydroxylation of the
carcinogen N-nitrosomorpholine. Journal of the American
Chemical Society, 108, 6066-6068, 1986.
15. Foiles, P.G., Chung, F.-L., Hecht, S.S. Development of a
monoclonal antibody-based immunoassay for cyclic DNA
adducts resulting from exposure to crotonaldehyde. Cancer
Research, 47, 360-363, 1987.
16. Chung, F.-L., Roy, K.R., Hecht, S.S. A study of reactions of
,-unsaturated carbonyl compounds with deoxyguanosine.
Journal of Organic Chemistry, 53, 14-17, 1988.
17. Wang, M., Chung, F.-L., Hecht, S.S. Identification of
crotonaldehyde as a hepatic microsomal metabolite formed by
-hydroxylation of the carcinogen N-nitrosopyrrolidine.
Chemical Research in Toxicology, 1, 28-31, 1988.
18. Morse, M.A., Wang, C.-X., Amin, S.G., Hecht, S.S., Chung,
F.-L. Effects of dietary sinigrin or indole-3-carbinol on O6methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA
methylation and tumorigenicity in F344 rats. Carcinogenesis,
9, 1891-1895, 1988.
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C.C., Chung, F.-L., Cai, Q., Gao, Y.-T., Zheng, W.
Urinary isothiocyanate excretion, Brassica consumption,
and gene polymorphisms among women living in
Shanghai, China. Cancer Epidemiology, Biomarkers &
Prevention, 12, 1536-1539, 2003.
109. Choudhury. S., Pan, J., Amin, S., Chung, F-L., Roy, R.
Repair kinetics of trans-4-hydroxynonenal-induced cyclic
1,N2-propanodeoxyguanine DNA adducts by human cell
nuclear extracts. Biochemistry, 43, 7514-7521, 2004
110. Wang, L., Liu, D., Ahmed, T., Chung, F.-L., Conaway, C,
Chiao, J.W. Targeting cell cycle machinery as a
molecular mechanism of sulforaphane in prostate cancer
prevention. Int. J. Oncol., 24(1), 187-92, 2004.
111. Myzak, M.C., Karplus, P.A., Chung, F.-L., Dashwood,
R.H. A novel mechanism of chemoprotection by
sulforaphane: inhibition of histone deacetylase. Cancer
Research, 64, 5767-5774, 2004.
112. Chiao, J.W., Wu, H., Ramaswamy, G., Conaway, C.C.,
Chung, F.-L., Wang, L., Liu, D. Ingestion of an
isothiocyanate metabolite from cruciferous vegetables
inhibits growth of human prostate cancer cell xenografts
by apoptosis and cell cycle arrest. Carcinogenesis, 25(8),
1403-1408, 2004.
113. Chung, F.-L., Komninou, D., Zhang, L., Nath, R., Pan, J.,
Amin, S., Richie, J. Glutathione depletion enhances the
formation of endogenous cyclic DNA adducts derived
from t-4-hydroxy-2-nonenal in rat liver. Chem. Res.
Toxicol., 18(1), 24-7, 2005.
114. Schwartz, J.L., Baker, V., Larios, E., Chung, F.-L.
Molecular and cellular effects of green tea on oral cells of
smokers: a pilot study. Mol. Nutr. Food Res., 49(1), 4351, 2005.
115. Yang, Y.-M., Jhanwar-Uniyal, M., Schwartz, J., Conaway,
C.C., Halicka, H.D., Traganos, F., Chung, F.-L. Nacetylcysteine conjugate of phenethyl isothiocyanate
enhances apoptosis in growth-stimulated human lung
cells. Cancer Res., 65(18), 8538-47, 2005.
116. Conaway, C.C, Wang, C-X., Pittman, B., Yang, Y-M.,
Schwartz, J.E., Tian, D., McIntee, E. J, Hecht, S.S.,
Chung, F.-L. Phenethyl Isothiocyanate and Sulforaphane
and Their N-Acetylcysteine Conjugates Inhibit Malignant
Progression of Lung Adenomas Induced by Tobacco
Carcinogens in A/J Mice. Cancer Res., 65(18), 8548-57,
2005.
117. Pan, J., Davis, W., Trushin, N., Amin, S., Nath, R.G.,
Salem Jr, N., Chung, F-L. A solid phase extraction/high
performance liquid chromatography-based 32Ppostlabeling method for detection of cyclic 1,N2propanodeoxyguanosine adducts derived from enals.
Analytical Biochemistry, 348, 15-23, 2006.
118. Agrawal, S., Winnik, B., Buckley, B., Mi, L., Chung, F.L., Cook, T.J. Simultaneous Determination of
Sulforaphane and its Major Metabolites from Biological
Matrices with Liquid Chromatography-Tandem Mass
Spectroscopy. J. Chromatogr B Analyt Technol Biomed
Life Sci., 840, 99-107, 2006.
119. Mi, L., Wang, X., Govind, S., Hood, B.L., Veenstra, T.D.,
Conrads, T.P., Saha, D.T., Goldman, R., Chung, F.-L. The
Role of Protein Binding in Induction of Apoptosis by
Phenethyl Isothiocyanate and Sulforaphane in Human
Non-small Lung Cancer Cells. Cancer Research, 67,
6409-6416, 2007.
120. Emami, A., Dyba, M., Cheema, A.K., Pan, J., Nath, R.G.,
Chung, F-L. Detection of the Acrolein-derived Cyclic
DNA Adduct by a Quantitative 32P-postlabeling/Solid
Phase Extraction/HPLC Method: Blocking its artifact
formation by Glutathione. Analytical Biochemistry,
374(1), 163-72, 2008.
121. Mi, L., Xiao Z., Hood, B.L., Dakshanamurthy S., Wang
X., Govind, S., Conrad T.P., Veenstra, T.D., Chung F-L.
Covalent binding to tubulin by isothiocyanates: a
mechanism of cell growth arrest and apoptosis. J. Biol.
Chem., 283, 22136-46, 2008.
122. Emami, A., Dyba, M., Cheema, A.K., Pan, J., Nath, R.G.,
Chung, F-L. Detection of the Acrolein-derived Cyclic
DNA Adduct by a Quantitative 32P-postlabeling/Solid
Phase Extraction/HPLC Method: Blocking its artifact
formation by Glutathione. Analytical Biochemistry,
374(1):163-72, 2008.
123. Moy, K.A., Yuan,J-M.,Chung, F-L., Van Den Berg, D.,
Wang, R., Gao, Y.-T., Yu, M.C., Urinary total
isothiocyanates in relation to colorectal cancer: a
prospective study of men in Shanghai, China, Cancer
Epidemiology Biomarker and Prevention, 17(6),13541359, 2008.
124. Epplein, M., Wilkens, L.R., Tiirikainen, M., Dyba, M.,
Chung, FL., Goodman, M.T., Murphy, S.P., Henderson, B.
E., Kolonel, L.N., Le Marchand, L. Urinary
isothiocyanates; glutathione S-transferase M1, T1, and P1
polymorphisms; and risk of colorectal cancer: the
Multiethnic Cohort Study. Cancer Epidemiology
Biomarker and Prevention, 18(1), 314-20, 2009.
125. Mi, L., Gan, N., Cheema, A, Dakshanamurthy, S, Yang, D. C.
H., Chung, F.-L. Cancer preventive isothiocyanates induce
selective degradation of cellular α- and β-tubulins by
proteasomes. J. Biol. Chem., 284, 17039-17051, 2009.
126. Pan J., Keffer J., Emami A., Ma X., Lan R., Goldman R.,
Chung, F-L. Formation of acrolein-derived DNA adduct in
human colon cells: its role in apoptosis induction by
docosahexaenoic acid. Chem. Res. Toxicol., 22, 798-806,
2009.
127. Moy, K.A., Yuan, J.-M., Chung, F.-L., Wang, X.-L., Van Den
Berg, D., Wang, R., Gao, Y-T., Yu, M.C. Isothiocyanates,
glutathione S-transferase M1 and T1 polymorphisms and
gastric cancer risk: a prospective study of men in Shanghai,
China. International J. of Cancer, 125(11), 2652-9, 2009.
128. Mi, L., Gan, N., Chung, F.-L. Aggresome-like structure
induced by isothiocyanates is novel proteasome-dependent
degradation machinery. Biochem. Biophys. Res. Commun.,
16;388(2), 456-62, 2009.
129. Gan, N., Mi, L., Sun, X., Dai, G., Chung, F.-L., Song, L.
Sulforaphane Protects Microcystin-LR-Induced Toxicity
through Activation of the Nrf2-Mediated Defensive Response.
Toxicol Appl Pharmacol., 247(2),129-37, 2010.
130. Nath, R.G., Wu, M.Y., Emami, A., Chung, F.-L. Effects of
epigallocatechin gallate, L-ascorbic acid, alpha-tocopherol,
and dihydrolipoic acid on the formation of deoxyguanosine
adducts derived from lipid peroxidation. Nutr. Cancer, 62(5),
622-9, 2010.
131. Kotsopoulos, J., Tworoger, S.S., Campos, H., Chung, F. L.,
Clevenger, C.V., Franke, A.A., Mantzoros, C.S., Ricchiuti, V.,
Willett, W.C., Hankinson, S.E., Eliassen, A.H.
Reproducibility of plasma and urine biomarkers among
premenopausal and postmenopausal women from the Nurses'
HealthStudies. Cancer Epidemiol. Biomarkers Prev., 19(4),
938-46, 2010.
132. Yang, G., Gao, Y.T., Shu, X.O., Cai, Q., Li, G.L., Li, H.L., Ji,
B.T., Rothman, N., Dyba, M., Xiang, Y.B., Chung, F.-L,
Chow, W.H., Zheng, W. Isothiocyanate exposure, glutathione
S-transferase polymorphisms, and colorectal cancer risk. Am.
J. Clin. Nutr., 91(3), 704-11, 2010.
133. Di Pasqua, A.J., Hong, C., Wu, M., McCracken, E., Wang, X.,
Chung, F.-L. Sensitization of non-small cell lung cancer cells
to the platinum anticancer agent cisplatin by naturally
occurring isothiocyanates. Chem. Res. Toxicol., 23(8), 13079, 2010.
134. Dyba, M., Wang, A., Noone, A.-M., Goerlitz, D., Shields,
Zheng, Y.-L., Rivlin, R., Chung, F.-L. Metabolism of
isothiocyanates in individuals with positive and null GSTT1
and M1 genotypes after drinking watercress juice. Clin.
Nutr., 29(6), 813-8, 2010.
135. Gan, N., Wu, Y.-C., Brunet, M., Garrido, C., Chung, F.-L.,
Dai, C., Mi, L. Sulforaphane activates heat shock response
and enhances proteasome activity through upregulation of
HSP27. J. Biol. Chem., 285, 35528-36, 2010.
136. Fowke, J.H., Gao, Y.-T., Chow, W.-H., Cai, Q., Shu, X.-O.,
Li, H.-I., Ji, B.-T., Rothman, N., Yang, G., Chung, F-L.,
Zheng, W., Urinary isothiocyanate levels and lung Cancer
risk among non-smoking women: a prospective investigation.
Lung Cancer, 73(1), 18-24, 2011.
137. Mi, L., Gan, N., Chung, F.-L. Isothiocyanates inhibit
proteasome activity and proliferation of multiple myeloma
cells. Carcinogenesis, 32(2), 216-23, 2011.
138. Wang, X., Di Pasqua, A. J., Govind, S., McCracken E., Hong
C., Mi, L., Mao, Y., Wu, J., Tomita Y., Woodrick, J. C.,
Fine R., and Chung, F-L., Selective depletion of mutant p53
by cancer chemopreventive isothiocyanates and its structureactivity relationships. J. Medicinal Chem., 54(3), 809-816,
2011.
139. Wang, X., Govind, S., Mi, L., Sajankila, S. P., Roy, Chung,
F.-L. Phenethyl isothiocyanate sensitizes human cervical
cancer cells to apoptosis induced by cisplatin. Mol. Nutr.
Food Res., 55(7), 2011.
140. Gan, N., Mi, L., Dai, G., Chung, F.-L., Song, L. Protection
against microcystin-LR-induced toxicity by sulforaphane
through activation of the Nrf2-mediated defensive response.
Toxicol. Appl. Pharmacol., 247(2), 129-37, 2010.
141. Kang, H.J., Hong, Y.B., Kim, H.J., Rodriguez, O.C., Nath,
R.G., Tilli, E.M., Albanese, C., Chung, F.-L., Kwon, S.H.,
Bae, I. Detoxification: a novel function of BRCA1 in tumor
suppression? Toxicol Sci., 122(1), 26-37, 2011.
142. Mi, L., Xiao, Z., Veenstra, T.D., Chung, F.-L., Proteomic
identification of binding targets of isothiocyanates: A
perspective on techniques. J Proteomics, 74(7), 1036-44,
2011.
143. Mi, L., Di Pasqua, A.J., Chung, F.-L. Proteins as binding
targets of isothiocyanates in cancer prevention.
Carcinogenesis, 32(10), 1405-13, 2011.
144. Sun, X., Mi, L., Liu, J., Song, L., Chung, F.-L., Gan, N.
Sulforaphane prevents microcystin-LR-induced oxidative
damage and apoptosis in BALB/c mice. Toxicol Appl
Pharmacol., 255(1), 9-17, 2011
145. Mi, L., Hood, B.L., Stewart, N.A., Xiao, Z., Govind, S.,
Wang, X., Conrads, T.P., Veenstra, T.D., Chung, F.-L.
Identification of Potential Protein Targets of
Isothiocyanates by Proteomics. Chem Res Toxicol.,
24(10), 1735-43, 2011.
146. Mi, L., Hood, B.L., Stewart, N.A., Xiao, Z., Govind, S.,
Wang, X., Conrads, T.P., Veenstra, T.D., Chung, F.-L.
Identification of Potential Protein Targets of
Isothiocyanates by Proteomics. Chem Res Toxicol.,
24(10), 1735-43, 2011.
147. Wang, H.T., Hu, Y., Tong, D., Huang, J., Gu, L., Wu,
X.R., Chung, F.-L., Li, G.M., Tang, M.S. Effect of
carcinogenic acrolein on DNA repair and mutagenic
susceptibility. J Biol Chem, 287(15), 12379-86, 2012.
148. Xiao, Z., Mi, L., Chung, F.-L., Veenstra, T.D. Proteomic
analysis of covalent modifications of tubulins by
isothiocyanates. J Nutr, 142(7), 1377S-81S, 2012.
149. Dash, C., Chung, F.-L., Rohan, J.A., Greenspan, E.,
Christopher, P.D., Makambi, K., Hara, Y., Newkirk, K.,
Davidson, B., Adams-Campbell, L.L. A six-month
crossover chemoprevention clinical trial of tea in smokers
and non-smokers: methodological issues in a feasibility
study. BMC Complement Altern Med, 12, 96, 2012.
150. Chung, F.-L., Wu, M.Y., Basudan, A., Dyba, M., Nath,
R.G. Regioselective formation of acrolein-derived cyclic
1,n(2)-propanodeoxyguanosine adducts mediated by
amino acids, proteins, and cell lysates. Chem Res
Toxicol, 17;25(9), 1921-8, 2012.
151. Greenspan, E.J., Lee, H., Dyba, M., Pan, J., Mekambi, K.,
Johnson, T., Blancato, J., Mueller, S., Berry, D.L., Chung,
F.-L. High-throughput, Quantitative Analysis of Acroleinderived DNA Adducts in Human Oral Cells by
Immunohistochemistry. J Histochem Cytochem, 60(11),
844-53, 2012.
152. Wang, H.T., Weng, M.W., Chen, W.C., Yobin, M., Pan,
J., Chung, F.-L., Wu, X.R., Rom, W., Tang, M.S. Effect
of CpG methylation at different sequence context on
acrolein- and BPDE-DNA binding and mutagenesis.
Carcinogenesis. 2012 Nov 1. [Epub ahead of print]
Reviews or Editorials in Refereed Journals
153. Hoffmann, D., Rivenson, A., Chung, F.-L., Hecht, S.S.
Nicotine-derived N-nitrosamines (TSNA) and their relevance
in tobacco carcinogenesis. CRC Critical Reviews in
Toxicology, 21, 305-311, 1991.
154. Hoffmann, D., Rivenson, A., Murphy, S.E., Chung, F.-L.,
Amin, S., Hecht, S.S. Cigarette smoking and adenocarcinoma
of the lung: the relevance of nicotine-derived N-nitrosamines.
Journal of Smoking-Related Disorders, 4, 165-189, 1993.
155. Chung, F.-L. Endogenous DNA adducts. The Toxicology
Forum, Summer Annual Meeting, 431-444, 1994.
156. Nath, R.G., Randerath, K., Li, D., Chung, F.-L. Endogenous
production of DNA adducts. Regulatory Toxicology and
Pharmacology (New York), 23, 22-28, 1996.
157. Chung, F.-L., Chen, H.-J.C., Nath, R.G. Lipid peroxidation as
a potential endogenous source for the formation of exocyclic
DNA adducts: a commentary. Carcinogenesis, 17, 21052111, 1996.
158. El-Bayoumy, K., Chung, F.-L., Richie, J., Reddy, B.S.,
Cohen, L., Weisburger, J., Wynder, E.L. Dietary control of
cancer. Diet and Cancer Control, 216, 211-223, 1997.
159. Chung, F.-L., Nath, R.G., Nagao, M., Nishikawa, A., Zhou,
G.-D., Randerath, K. Endogenous formation and significance
of 1, N2-propanodeoxyguanosine adducts. Mutation
Research, 424, 71-81, 1999.
160. Chung, F.-L. The prevention of lung cancer induced by a
tobacco-specific carcinogen in rodents by green and black
tea. Proceedings of the Society of Experimental
Biology and Medicine, 220, 244-248, 1999.
161. Chung, F.-L. Chemoprevention of lung cancer by
isothiocyanates and their conjugates in A/J mice.
Experimental Lung Research, 27, 319-330, 2001.
162. Weisburger, J.H., F.-L. Chung. Mechanisms of chronic
disease causation by nutritional factors and tobacco
products and their prevention by tea polyphenols. Food
Chemistry and Toxicology, 40, 145-1154, 2002.
163. Conaway, C.C., Yang, Y-M., Chung, F.-L.
Isothiocyanates as cancer chemopreventive agents: their
biological activities and metabolism in rodents and
humans. Current Drug Metabolism, 3, 233-255, 2002.
164. Chung, F.-L. Potential compounds in tea for the
prevention of lung cancer. Proceedings of 2001
International Conference on O-cha (Tea) Culture and
Science, Session III, Oct. 5-8, 2001, Zhizuoka, Japan, pp.
95-98.
165. Chung, F.-L., Schwartz, J., Herzog, C., Yang, Y.-M. Tea
and cancer prevention: Studies in animals and humans.
Journal of Nutrition, 133, 3268S-3274S, 2003.
166. Mi, L., Xiao, Z., Veenstra, T.D., Chung, F.-L. Proteomic
identification of binding targets of isothiocyanates: A
perspective on techniques. J Proteomics, 74(7), 1036-44,
2011.
167. Mi, L., Di Pasqua, A.J., Chung, F.-L. Proteins as binding
targets of isothiocyanates in cancer prevention.
Carcinogenesis, 32(10), 1405-13, 2011.
Books or Chapters in books, and publications in other journals
Publications in Books:
1.
Townsend, L.B., Bhat, G.A., Chung, F.-L., Schram, K.H.,
Panzica, R.P., Wotring, L.L. Synthesis, chemical reactivity,
biological and chemotherapeutic activity of certain tricyclic
nucleosides. In: Les Colloques de l'INSERM Nucleosides,
Nucleotides, Edition 81, (Barascut, J.-L., Imbach, J.-L.) pp.
37-82, INSERM, 1978.
2.
Hecht, S.S., Castonguay, A., Chung, F.-L., Hoffmann, D.,
Stoner, G.D. Recent studies on the metabolic activation of
cyclic nitrosamines. In: Banbury Report, 12th Edition
Nitrosamines and Human Cancer, ( ) pp. 103-120, Cold Spring
Harbor Laboratory, 1982.
3.
Hecht, S.S., Castonguay, A., Chung, F.-L., Hoffmann, D.
Carcinogenicity and metabolic activation of tobacco-specific
nitrosamines: current status and future prospects. In: N-Nitro
Compounds: Occurrence, Biological Effects and Relevance
to Human Cancer, 57th Edition, (O'Neill, I.K., Von Borstel,
R.C., Miller, C.T., Long, J., Bartsch, H.) pp. 763-778, IARC
Sci. Publ., 1984.
4.
Chung, F.-L., Juchatz, A., Vitarius, J., Reiss, B., Hecht, S.S.
Inhibition of target tissue activation of N'-nitrosonornicotine
and N-nitrosopyrrolidine by dietary components. In: N-Nitro
Compounds: Occurrence, Biological Effects and Relevance
to Human Cancer, Edition 57, (O'Neill, I.K., Von Borstel,
R.C., Miller, C.T., Long, J., Bartsch, H.) pp. 797-804, IARC
Sci. Publ., 1984.
5.
Chung, F.-L., Palladino, G., Hecht, S.S. Formation of cyclic
nucleic acid adducts from some simple , -unsaturated
carbonyl compounds and cyclic nitrosamines. In: The Role of
Cyclic Nucleic Acid Adducts in Carcinogenesis and
Mutagenesis, 70th Edition, (Singer, B., Bartsch, H.) pp. 207225, IARC Sci. Publ., 1986.
6.
Hecht, S.S., Carmella, S.G., Trushin, N., Foiles, P.G., Lin, D.,
Rubin, J.M., Chung, F.-L. Investigations on the molecular
dosimetry of tobacco-specific N-nitrosamines. In: Relevance
of N-Nitroso Compounds to Human Cancer: Exposure and
Mechanisms, Edition 84, (Bartsch, H., O'Neill, I.K., SchulteHermann, R.) pp. 423-429, IARC, 1987.
7.
Morse, M.A., Hecht, S.S., Chung, F.-L. Inhibition of tobaccospecific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1butanone (NNK)-induced lung tumors and DNA methylation in
F344 rats and A/J mice by phenethyl isothiocyanate. In:
Antimutagenesis and Anticarcinogenesis Mechanisms II,
Edition, (Kuroda, Y., Shankel, D.M., Waters, M.D.) pp. 345350, Plenum Publishing Co., 1990.
8.
Morse, M.A., Eklind, K.I., Hecht, S.S., Chung, F.-L. Inhibition
of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic
isothiocyanates. In: N-Nitroso Compounds, Mycotoxins and
Tobacco Smoke: Relevance to Human Cancer, Edition,
(O'Neill, I.K., Chen, J.S., Bartsch, H.) pp. 529-534, IARC Sci.
Publ., 1990.
9.
Hoffmann, D., Rivenson, A., Chung, F.-L., Hecht, S.S.
Relevance of nicotine-derived N-nitrosamines in tobacco
carcinogenesis. In: Effects of Nicotine on Biological Systems;
Advances in Pharmacological Sciences, Edition, (Adlkofer,
F., Thurau, K.) pp. 89-101, Birkhäuser Verlag, 1990.
10. Chung, F.-L., Xu, Y., Ho, C.-T., Desai, D., Han, C. Protection
against tobacco-specific nitrosamino-induced lung
tumorigenesis by green tea and its components. In: ACS
Symposium Series No. 507, Phenolic Compounds in Food
and Their Effects on Health II, Edition, (Huang et al.) pp.
300-307, 1992.
11. Chung, F.-L. Chemoprevention of lung carcinogenesis by
aromatic isothiocyanates. In: Cancer Chemoprevention,
Edition, (Wattenberg, L., Lipkin, M., Boone, C.W., Kelloff,
G.J.) pp. 227-245, CRC Press Inc., 1992.
12. Hecht, S.S., Morse, M.A., Eklind, K.I., Chung, F.-L. Recent
advances in chemoprevention. In: Chemoprevention of
Cancer, Edition, (Bhide, S.V., Maru, G.B.) pp. 1-15, Omega
Scientific Publishers, 1992.
13. Chung, F.-L., Morse, M.A., Eklind, K.I., Xu, Y. Inhibition of
the tobacco-specific nitrosamine-induced lung tumorigenesis
by compounds derived from cruciferous vegetables and green
tea. In: Tobacco Smoking and Nutrition: Influence of
Nutrition on Tobacco-Associated Health Risks, Edition 686,
(Diana, J.N., Pryor, W.A.) pp. 186-202, New York Academy of
Sciences, 1993.
14. Chung, F.-L., Morse, M.M., Eklind, K.I., Xu, Y. Mechanisms
of inhibition of tobacco-specific nitrosamine-induced lung
tumorigenesis in A/J mice. In: ACS Symposium Series No.
553, Nitrosamines and Related N-nitroso Compounds,
Edition, (Loeppky, R., Michejda, C.J.) pp. 232-247, American
Chemical Society, 1994.
15. Chung, F.-L., Xu, Y., Jin, C.-L., Wang, M. Tea as an
Antioxidant in the Prevention of Lung Cancer. In:
Proceedings of the International Conference on Food
Factors, Chemistry and Cancer Prevention, Edition,
(Ohigashi, H.) pp. 130-134, Springer-Verlag, 1997.
16.
Chung, F.-L., Zhang, L., Ocando, J.E., Nath, R.G. The role of
1,N2-propanodeoxyguanosine adducts as endogenous DNA
lesions in rodents and humans. In: Exocyclic DNA Adducts
in Mutagenesis and Carcinogenesis, 150th Edition, (Singer,
B., Bartsch, H.) pp. 45-54, IARC Sci. Publ., 1999.
17.
Chung, F.-L. Dietary isothiocyanates: Roles in cancer
prevention and metabolism in rodents and humans. In:
Phytochemicals in Nutrition and Health: Proceedings
from The Third International Conference on
Phytochemicals: From Harvest to Health, (Meskin, M.S.),
87-104, 2002.
18.
Chung, F.-L., Zhang, L. Deoxyguanosine adducts of t-4hydroxy-2-nonenal as marker of endogenous DNA
lesions. In: Redox Cell Biology & Genetics: Methods in
Enzymology, Edition 353 (Abelson, J.N. and Simon,
M.I.) pp. 523-536, Academic Press Inc., New York, 2002.
19.
Bailey, G.S., Chung, F-L., Nishikawa, A., Johnson, I.,
Shut, H., Stoner, G. Animal Studies: Metabolism Cancerpreventive effects, intermediary biomarkers. In: WHO,
IARC Handbook on Cancer Prevention, vol. 9:
Cruciferous Vegetables, Isothiocyanates and Indoles.
IARC, Lyon, France, 2004.
20.
Chung, F.-L. and Mi, L. Phytochemicals in the
Prevention of Lung Cancer Induced by Tobacco
Carcinogens. In: Alcohol, Tobacco, and Cancer, (Eds.
Cho, C.H., Purohit, V.) pp. 268-287, Basel, Karger, 2006.
PATENTS:
U.S. patent 4,923,813 on “Monoclonal antibody-based immunoassay for cyclic
DNA adducts resulting from exposure to crotonaldehyde and acrolein.” Date of
patent: May 8, 1990.
U.S. patent 5,114,969 on “Method of inhibiting lung tumors, arylalkyl
isothiocyanates, and method of synthesizing same.” Date of patent: May 19,
1992.
U.S. patent 5,231,209 on “Method of inhibiting lung tumors, arylalkyl
isothiocyanates, and method of synthesizing same.” Date of patent: July 27,
1993.
U.S. patent 5,391,568 on “Inhibition of lung tumorigenesis by administration of a
polyphenol.” Date of patent: February 21, 1995.
U.S. patent 6,433,011 on “Method for inhibiting formation of aberrant crypt foci
in the colon of a mammal.” Date of patent: August 13, 2002.
U.S. patent (pending approval) on “Compositions and methods for treating lung
cancer.”