Dr Ling-Ling Chen
PhD, Professor in Bioinformatics
Expertise Statement
Teaching Duties

Bioinformatics, Biostatistics, Computational Biology
Research Interests

Genome and transcriptome analysis of bacteria and plants

Construction of metabolic and protein-protein interaction network

Plant genome re-sequencing analysis
Professional Memberships

Reviewers for many international journals
Education & Working Experience
Working Experience

2008.12-Present
Professor, College of Life Science and Technology,
Huazhong Agricultural University, Wuhan 430070, P. R. China

2004.1-2008.11
Associate professor, School of Life Sciences, Shandong
University of Technology, Shandong, China

1999.8-2003.12
Instructor, School of Life Sciences and Chemical
Engineering, Zibo University, Shandong, China

1995.8-1996.8
Binzhou Dyeing Group Co., Ltd., Shandong, China
Education

2001.9-2004.6
Tianjin University, Tianjin, China. Ph.D. in Biophysics

1996.9-1999.7
Institute of Qingdao Chemical Engineering, Qingdao,
Shandong, China. M.S. in Chemical Engineering

1991.9-1995.7
Institute of Qingdao Chemical Engineering, Qingdao,
Shandong, China. B.S. in Chemical Engineering
Publications
1. Dijun Chen, ChunhuiYuan, Jian Zhang, Zhao Zhang, Lin Bai, Yijun Meng,
Ling-Ling Chen*, Ming Chen*. PlantNATsDB: a comprehensive database of
plant natural antisense transcripts. Nucleic Acids Res., 2012, 40: D1187-1193.
2. Qian Wang, Yang Lei, Xi-Wen Xu, Gejiao Wang*, Ling-Ling Chen*, Theoretical
prediction and experimental verification of protein-coding genes in plant
pathogen genome Agrobacterium tumefaciens strain C58. PLoS One, 2012, 7:
e43176.
3. Yang Lei, Shou-Kai Kang, Junxiang Gao, Xi-Shuai Jia and Ling-Ling Chen*,
Improved annotation of a plant pathogen genome Xanthomonas oryzae pv.
oryzae PXO99A J. Biomol. Struct. Dyn., 2012, in press.
4. Hong-Yu Zhang* ，Ling-Ling Chen, Xue-Juan Li, Jian Zhang. Evolutionary
inspirations for drug discovery. Trends Pharmacol Sci., 2010, 31: 443-448.
5. Na Gao, Ling-Ling Chen*, Hong-Fang Ji, Wei Wang, Ji-Wei Chang, Bei Gao,
Lin Zhang, Shi-Cui Zhang, Hong-Yu Zhang*. DIGAP - a database of improved
gene annotation for phytopathogens. BMC Genomics, 2010, 11: 54.
6. Junxiang Gao, Ling-Ling Chen*. Theoretical methods for identifying important
functional genes in bacterial genomes. Res. Microbiol., 2010, 161: 1-8.
7. Ling-Ling Chen*, Bin-Guang Ma, Na Gao. Reannotation of hypothetical ORFs
in plant pathogen Erwinia carotovora subsp. atroseptica SCRI1043. FEBS J.,
2008, 275: 198-206.
8. Ling-Ling Chen, Guang-Zhong Wang, Hong-Yu Zhang. Sterol biosynthesis and
prokaryotes-to-eukaryotes evolution. Biochem Biophys Res Commun., 2007,
363: 885-888.
9. Hong-Fang Ji, De-Xin Kong, Liang Shen, Ling-Ling Chen, Bin-Guang Ma,
Hong-Yu Zhang. Distribution patterns of small-molecule ligands in the protein
universe and implications for origin of life and drug discovery. Genome Biol.,
2007, 8: R176.
10. Bin-Guang Ma, Ling-Ling Chen, Hong-Yu Zhang. What determines protein
folding type? An investigation of intrinsic structural properties and its implication
for understanding folding mechanisms. J. Mol. Biol., 2007, 370: 439-448.
11. Hong-Fang Ji, Hong-Yu Zhang, Ling-Ling Chen. Why are prion diseases
precluded by non-mammals? Trends Biochem. Sci., 2007, 32: 206-208.
12. Guang-Zhong Wang, Ling-Ling Chen*, Hong-Yu Zhang. Phase-dependent
nucleotide substitution in protein-coding sequences. Biochem. Biophys. Res.
Commun., 2007, 355: 599-602.
13. Guang-Zhong Wang, Ling-Ling Chen, Hong-Yu Zhang. Neighboring-site effects
of amino acid mutation. Biochem. Biophys. Res. Commun., 2007, 353: 531-534.
14. Hong-Yu Ou, Ling-Ling Chen, James Lonnen, Roy R. Chaudhure, Ali Bin Thani,
et al. A novel strategy for the identification of genomic islands by comparative
analysis of the contents and contexts of tRNA sites in closely related bacteria.
Nucleic Acids Res., 2006, 34: e3.
15. Ling-Ling Chen*. Identification of genomic islands in six plant pathogens. Gene,
2006, 374: 134-141.
16. Ling-Ling Chen*, Feng Gao. Detection of nucleolar organizer and mitochondrial
DNA insertion regions based on the isochore map of Arabidopsis thaliana. FEBS
J., 2005, 272: 3328-3336.
17. Qing-Shan Fu, Feng Li, Ling-Ling Chen*. Gene expression analysis in six
GC-rich Gram-negative phytopathogens. Biochem. Biophys. Res. Commun.,
2005, 332: 380-387.
18. Bin-Guang Ma, Ling-Ling Chen*. The most deviated codon position in AT-rich
bacterial genomes: a function related analysis. J. Biomol. Struct. Dyn., 2005, 23:
143-149.
Funding

2013.01-2016.12

2012.01-2015.12 National High Technology Research and Development
National Natural Science Foundation of China (31271406)
Program (2012AA10A304)

2011.01-2013.12

2008.08-2010.12 National High Technology Research and Development
National Natural Science Foundation of China (31071659)
Program (2008AA09Z411)
Contact details
Email:
llchen@mail.hzau.edu.cn