CURRICULUM VITAE David Kandel Novick, Ph.D. Home Address: 31 Hampshire Ave Sharon, Mass 02067 Home phone: (781) 784-3894 Work Address: Science Department Chair Gann Academy, New Jewish High School of Greater Boston 333 Forest Street Waltham, Mass 02452 Work Phone: (781) 642-6800 Work Fax: (781) 642-6805 E-mail: dnovick@gannacademy.org EDUCATION: B.S. Biology with honors (Magna Cum Laud), Union College Schenectady, NY 12308 Ph.D. Biology, Tufts University June , 1988 November, 1997 Thesis Title: A Study of the Differentiation-dependent Turnover of Fatty Acid Synthase mRNA in 3T3-F442A Preadipocytes and Adipocytes and Expression Systems to Produce Heterologous mRNAs in 3T3-F442A Adipocytes. EXPERIENCE: Science Department Chair – Gann Academy, The New Jewish High School of Greater Boston, Waltham, Ma (August 22, 2005 – present): Chair of Science Department of seven faculty members. In this position, I oversee and mentor the professional development of members of my department. In addition, I direct the course of the science curriculum and use of the science facilities. In addition, I teach Advanced Biology and senior-electives such as, Advanced Topics in Biology and Biotechnology. In addition, I serve on the Department Head Committee and the Curriculum and Graduation Requirements Committee. Science Department Chair – Darrow School, New Lebanon, NY (August 24, 2001 – June 30, 2005): Chair of Science Department of five faculty members. In this position, I oversee and mentor the professional development of members of my department. In addition, I direct the course of the science curriculum and modernization/use of the science facilities, including the Samson Environmental Center. As department chair, I also serve on the Academic Review Committee (ARC), which is a recommending body that reviews the school wide curriculum, its design and implementation and the Department Head Committee (DHC), which deals with issues immediately affecting the operation and execution of the academic program. Science Department Chair - West Nottingham Academy, Colora, MD (August 15, 1999 – August 14, 2001): Chair Science Department of four faculty members. In this position, I have been working on modernizing the science curriculum and laboratory facilities in a variety of ways; first, by overseeing the redesigning of the academic curriculum to reflect the National Science Education Standards (National Research Council, 1996) and by incorporating technology, such as Calculator Based Labs. Second, by establishing collaborations and internships for students with local universities/businesses to further the hands-on experience for our students. Third and finally, by serving as a consultant on the design and implementation of a new science facility. In addition to my work within my department, I also serve as a member of the Educational Policy Committee (EPC), in which I oversee school wide curriculum design and implementation. Academic Dean - Center for Talented Youth Summer 2000 program at Moravian College, Bethlehem, PA (June 19 – July 16, 2000): Coordinated curriculum, scheduling, purchasing of all teaching materials and oversaw academic staff comprised of approximately 15 faculty and 20 teaching assistants. Acted as liaison between teachers and parents of students and dealt with discipline within the classroom. Served as part of the administrative team along with the Site Director and Residential Dean. Other administrative duties/experiences include: Darrow School (September, 2001 – June, 2005) – Member of ARC and DHC (see above). Served on the following Middle States Accreditation Committees: Science Curriculum Area Committee, Learning Media and Technology Committee, and Overall Strategic Planning Committee. Serve as Head Dorm Parent in Neale Dorm, a dorm that houses 20 boys ranging from the 9th to the 12th grade. West Nottingham Academy (August, 1999- August, 2001) - Member of EPC (see above). Serve as Administrator On Duty once a week and every third weekend and as Chairperson of the Faculty Intervention Team, which serves to intervene on students’ behalf before a health issue becomes a disciplinary issue. I have also served as Assistant Director of Community Service, helping students volunteer in the local community. Coaching Experience: Darrow School (September, 2001 – June, 2005) - Head Coach of Fencing and Assistant Coach of Baseball and Head Coach of JV Soccer. West Nottingham Academy (August, 1999- August, 2001) - Assistant Coach of football (Receiving) and of baseball. TEACHING EXPERIENCE: Teacher- Advanced Biology and a senior electives such as Biotechnology and Advanced Topics in Biology, Gann Academy, The New Jewish High School of Greater Boston, Waltham, Ma (August, 2005 – Present). I am teaching Advanced Biology to 11th graders and I am teaching or have taught senior elective courses such as, Advanced Topics in Biology and Biotechnology, respectively. Adjunct Faculty – BIO225 Biology, Colorado Technical University Online Main Campus 4435 N. Chestnut Street, Suite E Colorado Springs, CO 80907 (Sept 27, 2005 – present): I am teaching a general education online Biology course to undergraduates. This course uses a framework of real world scenarios to teach students basic concepts in Biology in a way that engages and teaches them real life skills. Adjunct Faculty - BIO-207 Microbiology, 4 Credits, Berkshire Community College (May 18 – August 4, 2004): An introduction to bacteria and other microorganisms-their scope, morphology, cultural characteristics, and metabolism-and to immunology and the role of the microorganism in health and disease. Additional topics include viruses and cancer, serology, theories of antibody formation, and the immune response as related to transplants and autoimmune diseases. Grade Level – undergraduate/adult Teacher – Biology, Chemistry, and senior electives such as, Stream Ecology and an upper-level Biotechnology course, Darrow School, New Lebanon, NY (September, 2001 – present): I am teaching Biology to 10th/11th graders, Chemistry to 10th graders, and senior electives, such as those listed above to 11th and 12th graders. Teacher – Biology and Environmental Science, West Nottingham Academy, Colora, MD (August, 1999 – August, 2001): I taught classes in environmental science and AP biology to 11th and 12th graders and biology to both traditional 10th graders and those with learning disabilities. Instructor- Introductory Biology (BIO 13), Tufts University, Medford, Mass (Each Fall, 1990-1997): I taught an introductory biology lab in which students were instructed on the scientific method of investigation in such diverse areas as Mendelian genetics, biochemistry, neurobiology, plant, molecular and cellular biology and immunology. These labs involved a 15 to 20 minute lecture in which I gave the students an overview of the theory behind the experiments they were going to perform, how they were applying what they learned in the lecture part of the course and how they could apply these techniques or methodology to solve other real life problems/questions. This was followed by hands-on instruction during execution of the experiments. Students were also instructed on how to maintain a scientific notebook to accurately record their findings and observations. They were then required to write up these findings in formal, journal style scientific reports. In addition to my duty as instructor of introductory labs, I attended the lecture part of the course and held weekly office hours where I not only advised students on laboratory matters but also helped them in digesting the materials taught. Instructor- Introductory Biology (BIO 14), Tufts University, Medford, Mass (Spring, 1997): I taught an introductory biology lab in which students were instructed on the scientific method of investigation in such diverse areas as population genetics, animal behavior and anatomy, plant biology and human physiology. These labs followed the same format as above. In addition, students were taught how to critically analyze their data through basic statistical analysis (Paired and unpaired T-tests, Chi-square analysis and ANOVA) and incorporate this statistical analysis in their interpretation of results. I also instructed students on how to use the Internet to search databases for information pertaining to the subjects studied and how to include this material in their reports. Orientation Teaching Advisor- Teacher Orientation Program, Center For Teaching and Advising (CENTA), Tufts University (1992-1995): I instructed first time graduate instructors on teaching methodologies, ways to advise students, sexual harassment issues and generally what they should or should not expect from their students. Laboratory and Teaching Assistant- Experiments In Biology, Tufts University, Medford, Mass (Spring, 1991-1993, 1996): I, along with the professor, gave hands-on instruction on the execution and understanding of each lab, which focused on teaching students tools of the biotechnology field. The course involved cloning and restriction analysis of the gene encoding beta-galactosidase, sequencing the gene and bacterial expression of a recombinant form of the protein (HIS tag), and batch purification of the recombinant protein over a nickel column. Teaching Assistant- Introductory Biology (BIO 14),Tufts University, Medford, Mass (Spring, 1994-1995): I attended the lecture part of the course which focused on animal behavior, population genetics and physiology and held weekly office hours where I advised students and helped them in digesting materials taught in the lecture part of the course. RESEARCH EXPERIENCE: Postdoctoral Associate: Human Medical Genetics Unit, University of Vermont College of Medicine, lab of Bertrand C. Liang, M.D. (January, 1998 – July, 1999). Research focused on the role of mitochondria and mitochondrial proteins, such as Bcl-2 and UCP2, in tumorgenesis, apoptosis and in resistance or sensitivity of cancer cells to cytotoxic drugs. Techniques used were: cell culture, determination of LD50’s for chemotherapeutic drugs, MTS assays, anchorage independent assays, low density plating, subcellular fractionation, fluorescent microscopy, flow cytometry, electroporation, recombinant DNA technology, Northern, Southern and Western analysis and statistical analysis using MAC based statistical software. Doctoral work: Department of Biology, Tufts University, lab of Kathleen Sue Cook, Ph.D. (September, 1990 - November, 1997). Doctoral research involved the study of the retinoic aciddependent and differentiation-dependent turnover of adipsin and fatty acid synthase mRNAs, respectively, in 3T3-F442A adipocytes and developing an expression system to produce heterologous mRNAs in this cell line. Techniques used were: recombinant DNA technology, transient or stable transfections using Calcium Phosphate or retroviral delivery systems, RNase protection, Northern and Southern analysis, RNase H analysis of Poly A tail length, monitoring mRNA turnover in vivo by pulse-chase analysis or by inhibiting transcription, monitoring mRNA turnover in an in vitro decay system and polysome distribution of mRNAs on linear sucrose gradients. Research Technician II: Department of Immunobiology, Dana Farber Cancer Institute, lab of Ellis Reinherz, M.D. (June 15, 1988 - July 31, 1990). Studied CD2/LFA3 interaction and its role in T cell recognition of nominal antigen and evaluation of Il-2 production studies in T cell receptor zeta/eta transfectants. Both projects resulted in publications (see publications). Techniques learned include: Maintenance of T and B cells, hybridomas, fibroblasts, etc..,3H Thymidine incorporation assays, Il-2 assays, antibody purification, ascites work, making heterokaryons, immunofluorescence, and a variety of recombinant DNA techniques. Undergraduate Research Thesis Project: Department of Biology, Union College, under the direction of Professor H. Butzel (September, 1987 - June, 1988). Investigating the biochemical mechanisms of transformation between two mouth forms (microstome and macrostome) in Tetrahymena vorex. Learned maintenance of axenic cultures. Summer internship: Environmental Health Institute, Pittsfield, Mass, under the direction of Arthur Bloom, M.D., Director (June - September, 1987). Assessed, through critical analysis of scientific literature, whether a genetically engineered microorganism released into the environment could or would mutate again in the wild and what effect, if any, these organisms might have on humans and other organisms. Also conducted a survey of over 35 scientists (e.g. Prof. Bernard Davis at Harvard Medical School), bioengineering firms (e.g. Advanced Genetic Sciences, Monsanto Inc., Ecova Co. and Gradient Co.) and government or private agencies (e.g. E.P.A., N.I.H., O.T.A. and National Audubon Society). Results of investigation were submitted in a report to Dr. Arthur Bloom. AWARDS AND HONORS: Teaching fellowship, Tufts University, Medford, Ma (1990-1997). Tuition Scholarship, Tufts University, Medford, Ma (1990-1997). Student Affairs Community Service Award, Tufts University, Medford, Ma (April 26, 1994). The Tufts Service Citation, Alumni Association, Tufts University, Medford, Ma (May 17, 1995). Elected as Associate Member of Sigma Χ, elected by the Union College Chapter, Schenectady, N.Y. (1988). ACTIVITIES: Founder and president, Graduate Student Council (GSC) of the Graduate School of Arts and Sciences (1992-1995). Graduate representative, Tufts University Steering Committee for the Capital Campaign (Fall, 1994- Spring, 1995). Organizer of graduate student sponsored seminar series, Tufts University, Department of Biology (Fall, 1993). PUBLICATIONS AND MEETING PRESENTATIONS: Bauer, A., McConkey DJ., Howard, FD., Clayton LK., Novick, D., Koyasu, S., Reinherz, EL. (1991). Differential signal transduction via T-cell receptor CD3 zeta 2, CD3 zeta-eta, and CD3 eta 2 isoforms. Proc. Nat'l Acad. Sci., USA. 88(9): 3842-6. Koyasu, S., Lawton, T., Novick, D., Recny, MA., Siliciano, RF., Wallner, BP., Reinherz, EL. (1990). Role of interaction of CD2 molecules with lymphocyte function-associated antigen 3 in T-cell recognition of nominal antigen. Proc. Nat'l Acad. Sci., USA. 87(7): 2603-7. Novick, D., Miller, L. and Liang, B.C. Inhibition Of The Electron Transport Chain Sensitizes Neoplastic Cells To Cytotoxic-Induced Death. (Poster) 15th Regional Cancer Research Symposium, “Targeted Therapeutics in Cancer”. Vermont Cancer Center March 29 & 30, 1999. Radisson Hotel, Burlington, VT. Novick, D., Miller, L. and Liang, B.C. Inhibition Of The Electron Transport Chain Sensitizes Neoplastic Cells To Cytotoxic-Induced Apoptosis. (Poster) 2nd Albany Conference On, “Frontiers Of Mitochondrial Research”. September 24 – 27, 1998. Rensselaerville, N.Y. Novick, D. and Cook, K.S. Role of translation in the differentiation-dependent stabilization of Fatty Acid Synthase mRNA in 3T3-F442A adipocytes. (Selected Poster) American Institute For Cancer Research Annual Research Conference, "Dietary Fat and Cancer: Genetic and Molecular Interactions". August 29 & 30, 1996. Washington, D.C. Novick, D., Tirabassi, M. and Cook, K.S. A functional assay for identifying nucleotide sequence elements required for regulated mRNA turnover in 3T3 adipocytes. (Poster) Boston Obesity Nutrition Research Center Meeting on Adipose Tissue. Nov. 9, 1995. Woods Hole, Ma. Novick, D. and Cook, K.S. A method for studying the regulation of mRNA turnover in 3T3adipocytes. (Poster) Northeast Regional Developmental Biology Meeting. April 15-17, 1994. Woods Hole, Ma. REFERENCES: Judith Pordes Acting Head of School Gann Academy 333 Forest Street Waltham, Mass 02452 (781) 784-6800 Ext. 102 jpordes@gannacademy.org Christopher W. Maund Dean of Instruction Colorado Technical University Online 4435 N. Chestnut Street, Suite E Colorado Springs, CO 80907 Toll Free: 800-416-8904 x68724 Direct Fax: 847-586-7724 Email: CMaund@ctuonline.edu Nancy Wolf Head of School Darrow School 110 Darrow Rd New Lebanon, NY 12125 Phone: (518) 794-6005 Email: wolfn@darrowschool.org Clark Thomson Director of Studies Darrow School 110 Darrow Road New Lebanon, NY 12125 Phone: (518) 794-6017 Email: thomsonc@darrowschool.org Don Singleton Dean of Students Darrow School 110 Darrow Road New Lebanon, NY Phone: (518) 794-6018 Email: birchs@darrowschool.org Craig Westcott Curriculum Coordinator Darrow School 110 Darrow Road New Lebanon, NY Phone: (518) 794-6016 Email: westcottc@darrowschool.org Dr. Charles Kaminski Assistant Dean of Business and Science Berkshire Community College 1350 West St Pittsfield, Ma 01201 (413) 499–4660 Ext. 270/262 Email: ckaminsk@berkshirecc.edu Victoria N. Londergan (was Director of Studies, West Nottingham Academy) Head of School Jarrow Montessori School 3900 Orange Court Boulder, Colorado 80304 Phone: 303-443-0511 Email: headofschool@jarrow.org Tim Pearson Site Director, Center For Talented Youth Summer 2000 Program at Moravian College 1224 Punta Gorda St. Santa Barbara, Ca 93103 home - 805-966-4871 work - 805-569-1811 Bertrand C. Liang, M.D. Amgen, Inc. One Amgen Center Drive Thousand Oaks, CA 91320 Phone: 805-447-6315 FAX: 805-480-1330 E-mail: bliang@amgen.com Dr. George Ellmore Department of Biology Tufts University Medford, Ma 02155 Phone: (617) 627-3195 FAX: (617) 627-3805 E-mail: gellmore@emerald.tufts.edu Dr. Ross Feldberg Department of Biology Tufts University Medford, Ma 02155 Phone: (617) 627-3196 FAX: (617) 627-3805 E-mail: rfeldber@emerald.tufts.edu Dr. Shigeo Koyasu Department of Microbiology and Immunology Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku Tokyo 160, Japan Phone: 81(Japan)-3-3353-1746 FAX: 81(Japan)-3-5361-7658 E-mail: koyasu@sun.microb.med.keio.ac.jp