Resident Exam - Pediatric Sedation Blog

advertisement

Version 2009-2010 Resident’s Initials___________

Resident’s Name:______________________________________________________

CHaD PAIN FREE ROTATION for PEDIATRIC INTERNS

PROBLEM BASED EXAMINATION

1) A 22 month old, former 35 week premie, is scheduled for an MRI scan as part of the workup for new-onset seizures. The family had a previous child who died in the hospital as a neonate secondary to complex congenital heart disease. This child has had a normal echocardiogram and had several episodes of reactive airway disease over the past winter which were treated with albuterol.

1. The risk of any anesthetic/sedation is related to:

1. Patient co-morbidities

2. Duration and complexity of the procedure

3. Current health status (asthma flair-up, upper respiratory tract infection, etc)

4. Patient age

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

2. List at least 6 patient-related factors which increase the risk of complications

during procedural anesthesia/sedation:

___________________________________________

___________________________________________

___________________________________________

___________________________________________

___________________________________________

___________________________________________

3. A reasonable presedation laboratory screening protocol might include:

A. An echocardiogram in all patients less than 1 year old

B. A preoperative hematocrit in patients whose procedure or personal history

predict a risk of blood loss or anemia

C. A complete blood count (CBC), chemistry panel and urinalysis in all

pediatric patients

D. An HIV test in all sexually active patients

E. A chest x-ray in all patients with a history of reactive airway disease

_______ SINGLE BEST ANSWER

Version 2009-2010 Resident’s Initials___________

4. True statements about blanket preoperative/presedation screening include:

1. Preoperative screening tests may be very expensive

2. Surgery or diagnostic procedures may be delayed

3. False-positive tests may need to be pursued further

4. Blanket preoperative screening is associated with improved perioperative

outcome

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

5. Define the American Society of Anesthesiologists (ASA) physical status classification system:

Class I-

Class II-

Class III-

Class IV-

Class V-

Version 2009-2010 Resident’s Initials___________

6. When deciding what level of sedation/anesthesia is appropriate for a particular

procedure, factors to take into account include all of the following EXCEPT:

A.

Age and temperament of the child

B.

Presence or absence of a student observer

C.

Type of procedure and amount of pain involved

D.

Amount of immobility required

E.

Patient and parental anxiety level

_______ SINGLE BEST ANSWER

7. A presedation screening history should include (list at least six things):

___________________________________________

___________________________________________

___________________________________________

___________________________________________

___________________________________________

___________________________________________

8. A presedation screening physical exam should include (list at least six things):

___________________________________________

___________________________________________

___________________________________________

___________________________________________

___________________________________________

___________________________________________

9. The parents state that they “do not want their child sedated for the MRI scan”.

Non-pharmacologic interventions include:

1.

Parental presence

2.

Child life involvement to facilitate a non-threatening and age-appropriate approach to the child

3.

Relaxation-imagery and distraction techniques

4.

Promising the patient that the procedure will not be scary

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Version 2009-2010 Resident’s Initials___________

2) A 3 year old boy is scheduled for a bone scan under sedation. He is otherwise healthy, of normal weight and has a normal airway exam. His parents state that he hasn’t eaten since the previous evening and that he had some sips of Gatorade three hours prior to arriving at the hospital for his bone scan. He receives a mask induction with nitrous oxide and sevoflurane in oxygen, followed by propofol continuous sedation. He maintains a natural airway and receives supplemental oxygen via a Hudson mask.

1. NPO guidelines can be more liberal (ie, allow food and drink closer to the time of

the procedure) for patients scheduled for sedation vs. those scheduled for general

anesthesia.

A. TRUE

B. FALSE

_______ SINGLE BEST ANSWER

2. True statements about NPO standards include:

1. NPO standards have recently been relaxed to allow ingestion of solid food

until 4 hours prior to elective anesthesia/sedation

2. NPO standards have recently been relaxed to allow ingestion of clear liquids

until 2 hours prior to elective anesthesia/sedation

3. High risk patients (hiatal hernia, GERD) are no longer at risk for perioperative

aspiration if they have been NPO for at least 6 hours

4. Emergency patients are almost always treated as having a “full” stomach

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

3. DHMC’s current NPO policy is:

Ingested Material Minimum Fasting Period (hours)

Version 2009-2010 Resident’s Initials___________

4. “Clear” liquids include:

1.

Water

2.

Juice without pulp

3.

Ginger Ale

4.

Coffee with milk

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

5. Prolonged preoperative fasting in infants can lead to:

1.

Hypoglycemia

2.

Irritability

3.

Dehydration

4.

Crouzon syndrome

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

At the end of the procedure, while emerging from sedation, the patient vomits. His pharynx is suctioned thoroughly and he is placed on his side until his airway reflexes are fully intact. He exhibits no respiratory distress, and his room air saturation is 98%. When you questioning the family further about his NPO status, his six year old sister states that on the way to the hospital her brother ate two chicken nuggets and several French fries which he found lodged in the backseat of the car.

6. Aspiration of gastric contents is a potentially fatal complication of procedural

sedation.

A. TRUE

B. FALSE

_______ SINGLE BEST ANSWER

7. Conditions that increase the risk of periprocedural aspiration of gastric contents

include:

1.

Recent ingestion of food

2.

Hiatal hernia

3.

Gastroesophageal reflux disease (GERD)

4.

Obesity

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Version 2009-2010 Resident’s Initials___________

8. Severity of aspiration is related to:

1.

Presence of particulate matter

2.

Volume of the aspirate

3.

Acidity of the aspirate

4.

Glucose content of the aspirate

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Version 2009-2010 Resident’s Initials___________

3) A 6 month old, 6.4 kg child with new onset seizures is scheduled for an MRI scan of the brain. He receives 480 mg (~75 mg/kg) of chloral hydrate PO, and begins to fall asleep. An IV is placed because he will need IV contrast. About halfway through the procedure he gets restless and the scan is interrupted. The patient is given 0.3 mg (~0.05mg/kg) of midazolam IV, settles down and scanning resumes. Several minutes later it is noted that the patient’s oxygen saturation is 72%. The patient is pulled out of the scanner and noted to be apneic.

1. Define the following terms which are currently in use to describe sedation/anesthesia

in pediatric patients:

Minimal sedation (anxiolysis)-

Moderate sedation (conscious sedation)-

Deep sedation-

General anesthesia-

2. True statements about sedation in children include all of the following EXCEPT:

Version 2009-2010 Resident’s Initials___________

A. Rescue equipment, including size-appropriate equipment and drugs to

resuscitate a nonbreathing and/or unconscious child, must be immediately

accessible.

B. The intensity of monitoring is determined by the expected level of sedation

C. Sedation personnel and monitoring equipment should always be capable of

caring for a patient at least one level beyond the intended level of sedation.

D. Sedation/general anesthesia is a continuum, rather than a set of distinct phases

E. Progression through the phases of sedation/general anesthesia is linear, so it is

easy to predict when a patient will enter another phase

_______ SINGLE BEST ANSWER

3. The risk that a patient will become more sedated than intended is increased:

1. In younger patients

2. In sicker patients

3. When pharmacologic agents are mixed

4. In red-headed patients

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

4. Patients receiving minimal sedation (anxiolysis)

1. Have intact airway reflexes

2. May have mildly impaired cognitive function

3. Should not require monitoring beyond a pulse oximeter and/or direct

observation

4. Are not known to progress to a level of moderate sedation (conscious

sedation)

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

5. Patients receiving moderate sedation (conscious sedation)

1. Should be able to maintain a patent airway

2. Do not need to be monitored in a suitably equipped recovery facility after the

procedure is completed, as is done with patients who have received deep

sedation

3. May progress into a state of deep sedation and obtundation

4. Require monitoring with pulse oximeter only

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

6. Patients receiving deep sedation

Version 2009-2010 Resident’s Initials___________

1. Incur risks similar to those undergoing general anesthesia

2. Must receive continuous monitoring of oxygen saturation and heart rate,

intermittent recording of respiratory rate and blood pressure, and

consideration of the use of a capnograph

3. Must be monitored in a PACU-like setting post-procedure

4. Should have an intravenous line placed before or shortly after induction

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Version 2009-2010 Resident’s Initials___________

4) A 5 year old, 22 kg, boy with Treacher Collins syndrome and an abdominal mass presents for an MRI scan of the abdomen which will require that the patient’s breathing be suspended intermittently. He has never had an anesthetic previously. He has an IV in place. At induction he receives 20 mg lidocaine, 80 mg propofol and 20 mg rocuronium IV. Neither the glottis nor the epiglottis are visualized with a Mac 2 blade. The patient is difficult to ventilate using a face mask.

1.

Name at least six things which might predict a difficult intubation

________________________________________

________________________________________

________________________________________

________________________________________

________________________________________

________________________________________

2. Describe the Mallampati airway classification system:

Class I-

Class II-

Class III-

Class IV-

Version 2009-2010 Resident’s Initials___________

3. Patients who are difficult to intubate are also usually impossible to ventilate via face

mask.

A. TRUE

B. FALSE

_______ SINGLE BEST ANSWER

4. What steps can be taken to improve ventilation by face mask in this patient?

1.

2.

3.

5. Once adequate ventilation by face mask has been established for this patient, describe

the management options which exist for this patient. (Refer to the ASA difficult

airway algorithm).

6. The laryngeal mask airway (LMA)

1.

Cannot be used in patients who are latex allergic

2.

Comes in a variety of sizes and styles

3.

Forms a high pressure seal around the entrance to the larynx and prevents aspiration of gastric contents

4.

Can be used in the emergency establishment of an airway

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Version 2009-2010 Resident’s Initials___________

7.

Tracheal intubation may be confirmed by

1.

Auscultation of bilateral breath sounds

2.

Detection of end-tidal CO

2

3.

Fiberoptic bronchoscopy

4.

SpO

2

of 100%

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

8.

Complications of direct laryngoscopy and intubation include

1.

Esophageal intubation

2.

Dental damage

3.

Endobronchial intubation

4.

Increased intracranial pressure

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

9.

After multiple attempts by multiple people using multiple techniques, the above patient was finally intubated fiberoptically through an LMA. He was transported to the MRI scanner and the scan was completed uneventfully. True statements about extubation of this patient include:

1.

Before removing this patient’s ETT, the cuff should be deflated to check for a gas leak around the ETT

2.

Consideration should be given to delaying extubation until airway edema has resolved

3.

Consideration should be given to removing this patient’s ETT over a fiberoptic scope, ETT tube changer, or jet stylet.

4.

This patient should be extubated “deep” (while still deeply anesthetized) to prevent coughing, breath-holding and laryngospasm.

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Version 2009-2010 Resident’s Initials___________

5) An 8 month old infant is scheduled for a nuclear medicine scan with sedation. He is a former full term infant who is otherwise healthy. He has no IV access.

1. Initially, you consider using chloral hydrate for this child. True statements about

chloral hydrate include:

1.

In most patients, airway reflexes and respiratory drive are well maintained during chloral hydrate sedation

2.

The dose of chloral hydrate is 50-100mg/kg, with a maximum dose of 2gm

3.

Care should be taken in administering chloral hydrate to developmentally delayed children (who may have an exaggerated or dysphoric reaction) or to patients with potential upper airway obstruction (enlarged tonsils, OSA, laryngomalacia)

4.

Chloral hydrate works by inducing a dissociative state between the cortex and the limbic system

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

2. Reasons that chloral hydrate might be a good choice in this patient include:

1.

Chloral hydrate is administered PO or PR, so it is a good choice in patients without

IV access

2.

Chloral hydrate provides no analgesia, so it is a good choice in diagnostic, nonpainful procedures such as this one

3.

Chloral hydrate works best in patients less than three years of age (about a 90% efficacy rate in this age group)

4.

Chloral hydrate is a short acting drug- patients awaken very quickly- so it is a good choice for this relatively short procedure

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

3. You learn that the patient will need an IV placed prior to the nuclear medicine scan so

that a radionucleotide tracer can be injected prior to the scan. You would like to use

EMLA cream before placing the IV.

1. EMLA stands for “Eutectic Mixture of Local Anesthetics”, and contains the

local anesthetics lidocaine and prilocaine

2. EMLA has a quick onset of action, allowing an IV to be started 3-5 minutes

after the cream has been placed

3. EMLA has been associated with methemoglobinemia

4. EMLA cream can be used safely on mucous membranes, open skin and in

neonates (infants less than one month of age)

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Version 2009-2010 Resident’s Initials___________

4. Since the patient now has an IV in place, you decide instead to use midazolam for

sedation. Benzodiazepines can be used for:

1. Anxiolysis

2. Sedation

3. Amnesia

4. The control of seizures

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

5. Midazolam can be administered

1. Orally, rectally

2. Intranasally

3. Intravenously

4. Intramuscularly

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

6. True statements about midazolam include:

1. Midazolam is a GABA

A

receptor agonist

2. Midazolam has a longer ½ life than diazepam

3. Midazolam is rapidly metabolized by hydroxylation

4. After administration, midazolam is not detected in the brain or CSF

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

7. True statements about oral midazolam include:

1. An advantage of using oral midazolam is that there are no first-pass hepatic

effects

2. Oral midazolam has a pleasant and easily tolerated taste

3. The onset of sedation after the administration of oral midazolam is usually 2-3

minutes

4. Oral midazolam is typically administered in doses ranging from 0.5-1.0 mg/kg

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

8. True statements about intravenous midazolam include:

Version 2009-2010 Resident’s Initials___________

1. It burns on administration

2. It is easily titrated

3. It has analgesic properties

4. The usual dose is 0.05- 0.1 mg/kg

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

You give the patient 0.1mg/kg midazolam intravenously. He quiets down and the scan resumes. Shortly afterwards you note that his respiratory rate has fallen from 26/min to 6/min.

His oxygen saturation is 98%. After assuring that his airway is patent, you decide to administer flumazenil.

9. True statements about flumazenil include all of the following EXCEPT:

A. Flumazenil is a GABA

A

receptor agonist

B. The dose of flumazenil is 0.02 mg/kg intravenously, which may be repeated

every minute as needed up to a maximum of 1.0 mg

C. The onset of action of flumazenil is approximately one minute

D. Side effects of flumazenil include crying, agitation, headache, dizziness and

nausea/vomiting

E. After receiving flumazenil, patients should be observed for at least 50 minutes

to be certain that the patient does not become resedated.

_______ SINGLE BEST ANSWER

Version 2009-2010 Resident’s Initials___________

6) A 6 year old girl is scheduled for a VCUG and removal of a periurethral skin tag. She is otherwise healthy and takes no medications on a regular basis. She has a class I airway. When you visit her in the preoperative holding area she does not yet have an IV in place.

1. The patient would like to “go to sleep” before getting an IV. Mask induction of

general anesthesia could be easily accomplished with which of the following agents?

1. Halothane

2. Desflurane

3. Sevoflurane

4. Nitrous oxide

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

2. The effects of volatile anesthetic agents are presumed to be dependent on the

achievement of therapeutic tissue concentrations in the brain. Factors affecting the

concentration of volatile anesthetic agents in the brain include:

1. The inspired concentration of the anesthetic agent

2. Alveolar blood flow

3. Ventilation of the lungs

4. Presence of carotid artery disease

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

3. Anesthetic agents that are relatively insoluble in blood (small blood/gas coefficients)

will provide a faster induction

A. TRUE

B. FALSE

_______ SINGLE BEST ANSWER

4. Define minimum alveolar concentration (MAC):

Version 2009-2010 Resident’s Initials___________

5. You decide that you would prefer to proceed with induction with an IV in place, so

you place an IV in the patient in the preoperative area. Which of the following agents

could then be used for IV induction of anesthesia?

1.

Propofol

2.

Sodium pentothal

3.

Ketamine

4.

Etomidate

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

6. Advantages of propofol include

1. Rapid onset of action

2. Rapid recovery after initial bolus dose

3. Ease of titration

4. Absence of respiratory depression

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

7.

Disadvantages of propofol include

1. Sepsis secondary to contaminated propofol

2. Pain on injection

3. Metabolic acidosis, and even death, with prolonged use

4. Emetogenic properties

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

8.

True statements about barbiturates include all of the following EXCEPT:

A. The longest acting of the barbiturates is methohexital, a property which is

related to the methyl group substituted at N

1

B. Barbiturates depress the reticular activating system (RAS) to produce

unconsciousness

C. The duration of action of thiopental is primarily dependent on redistribution

D. In patients who are hypovolemic, the administration of an induction dose of

sodium pentothal may lead to a dramatic fall in blood pressure and cardiac

output

E. Barbiturates significantly decrease CMRO

2

(cerebral metabolic rate of

oxygen) and may provide some brain protection from transient focal brain

ischemia

_______ SINGLE BEST ANSWER

Version 2009-2010 Resident’s Initials___________

9.

True statements about ketamine include all of the following EXCEPT:

A. Ketamine produces so-called “dissociative anesthesia” by functionally

disconnecting the cortex from the limbic system.

B. Although ketamine is a structural analogue of phencyclidine (PCP), it is so

much less potent that it has no “street value” and therefore is not a controlled

drug.

C. Ketamine has sympathomimetic properties. It may actually increase blood

pressure and cardiac output. It significantly increases cerebral metabolic rate,

cerebral blood flow and intracranial pressure.

D. Ketamine produces very little, if any, respiratory depression

E. Ketamine leads to excessive salivation, but luckily airway reflexes remain

largely intact

_______ SINGLE BEST ANSWER

10.

The periurethral skin tag turns out to be fairly large. You decide to administer

narcotics intraoperatively for perioperative pain relief. True statements about opioids

include all of the following EXCEPT:

A. Opioid is a broad term which includes endogenous peptides and exogenous

drugs- both naturally occurring and synthetically produced- which act at the

opioid receptor

B. There are four major types of opioid receptors: mu, kappa, delta, and sigma

C. Opioid receptor activation inhibits the presynaptic release and post-synaptic

response to excitatory neurotransmitters like substance P in the nociceptive

neurons

D. Opioids given in combination with benzodiazepines can have synergistic

(greater than additive) respiratory depressant effects

E. Although the hypoxic respiratory drive (response to PaO

2

) is affected by the

administration of narcotics, the respiratory response to PaCO

2

is maintained.

_______ SINGLE BEST ANSWER

11.

Effects of opioids include:

1. Somnolence and/or respiratory depression

2. Dysphoria

3. Nausea and/or pruritis

4. Euphoria

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Version 2009-2010 Resident’s Initials___________

12.

Morphine:

1. Is metabolized via glucuronidation in the liver

2. Is typically dosed at 0.05-0.1 mg/kg IV

3. Has an active metabolite which can accumulate in renal failure, so must be

used cautiously in patients with impaired renal function

4. Is not associated with histamine release or pruritis

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

13.

True statements about meperidine include:

1. Meperidine’s active metabolite, normeperidine, has been associated with

seizure activity

2. Meperidine is contraindicated in patients taking MAO inhibitors

3. A typical dose of meperidine is 0.5 mg/kg IV

4. Meperidine is often used IM because it is rapidly absorbed intramuscularly

and peak blood levels can be reached in about 10 minutes

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

14.

True statements about fentanyl include:

1. A typical dose of fentanyl is 1-2 μg/ kg IV

2. Fentanyl is 100 times more potent than morphine

3. Fentanyl has been associated with stiff chest syndrome

4. Because of its poor lipid solubility and slow redistribution, fentanyl has a slow

onset and a long duration of action

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

15.

Because you have administered an opioid, you double check to be sure that you

have naloxone immediately available. True statements about naloxone include:

1. Naloxone will reverse opioid-induced analgesia as well as opioid-induced

respiratory depression, so patients may experience pain after its administration

2. Naloxone administration has been associated with the development of

ventricular fibrillation and pulmonary edema

3. Naloxone administration has been associated with nausea and vomiting

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

4. Naloxone has a long duration of action, so the risk of re-narcotization is very

small

Version 2009-2010 Resident’s Initials___________

16.

In addition to the opioid, you administer ketorolac 0.5mg/kg IV. True statements

about ketorolac include all of the following EXCEPT:

A. Ketorolac potentiates opioid analgesia and can reduce opioid consumption

B. Ketorolac is a cox-2 specific inhibitor and, as such, is less likely to result in stomach ulceration and bleeding

C. Ketorolac is the only parenterally administered NSAID currently available in

the United States

D. Ketorolac use has been associated with renal failure

E. Ketorolac should be used with caution, if at all, in patients less than a year of

age because of the lack of pharmacokinetic and toxicity information in that

age group

_______ SINGLE BEST ANSWER

Version 2009-2010 Resident’s Initials___________

7) A 12 year old girl is scheduled for excision of a mole from her thigh. The surgeons are concerned about injecting local anesthetic into the surgical site because the patient describes an

“allergic reaction” to “novocain”, which she received once at the dentist’s office.

1.

Considerations in a patient with a “novocain” allergy include:

1. “Novocain” is frequently used by patients to refer to all local anesthetic agents

(LAs), but novocain (procaine) is rarely used clinically today

2. Most “allergic” reactions to local anesthetics are actually vasovagal reactions

to the injection of the LA, tachycardia and/or hypertension secondary to

systemic absorption of the epinephrine in the LA solution, or the effect of high

blood levels of LAs, rather than a true allergy

3. True allergic reactions to local anesthetics usually occur with the ester type

LAs, not the amide type LAs.

4. Allergic reactions to the preservative (methylparaben) in LAs are more

common than allergic reactions to local anesthetics themselves.

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

2.

Local anesthetic agents are weak bases, consisting of a lipophilic group (usually a benzene ring) linked to a hydrophilic group (usually a tertiary amine) through an _____________ or

_____________ linkage.

3.

A 1% solution of local anesthetic has _________mg/ml of local anesthetic.

4.

Briefly describe the mechanism of action of local anesthetic agents:

5.

List at least three ester type local anesthetic agents and at least three amide type local anesthetic agents:

Ester type local anesthetic agents Amide type local anesthetic agents

Version 2009-2010 Resident’s Initials___________

6.

Ester-type local anesthetics are predominantly metabolized by:

7.

Amide-type local anesthetics are predominantly metabolized by:

8.

True statements include all of the following EXCEPT:

A. Acidic pH will hasten the onset of the local anesthetic block

B. Myelinated nerves are more easily blocked than non-myelinated nerves,

because blockade need only occur at the nodes of Ranvier

C. With careful choice of local anesthetic agent, dose, and concentration, a

selective block may be obtained (eg block of pain and temperature sensation

in the absence of significant motor blockade)

D. Local anesthetic molecules must traverse the neural cell membrane in order to

bind to the sodium channels and produce their effect

E. In general, thinner nerve fibers are more easily blocked than thick nerve fibers

_______ SINGLE BEST ANSWER

9.

Epinephrine is often added to local anesthetics to:

1. Decrease systemic absorption via vasoconstriction, and therefore enhance

neuronal uptake

2. Prolong the duration of action

3. Limit the toxic side effects of local anesthetics

4. Pretreat local anesthetic toxicity

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

10.

Local anesthetic blockade of peripheral nerves usually progresses in the following order:

A. Autonomics  temperature  motor  pain  proprioception

B. Autonomics

temperature

pain

proprioception

motor

C. Motor

proprioception

pain

temperature

autonomics

D. Temperature

pain

proprioception

motor

autonomics

E. Motor

temperature

pain

proprioception

autonomics

_______ SINGLE BEST ANSWER

11.

Signs and symptoms of local anesthetic toxicity include the following:

Version 2009-2010 Resident’s Initials___________

1. Seizure

2. Dizziness, tinnitus, metallic taste in the mouth, numbness of tongue or lips

3. Arrhythmias

4. Cardiovascular collapse

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

12.

Signs of CNS toxicity usually precede signs of cardiovascular toxicity with local anesthetics

A. TRUE

B. FALSE

_______ SINGLE BEST ANSWER

13.

Treatment of systemic local anesthetic toxicity may include:

1. Administration of a benzodiazepine, like midazolam

2. Hyperventilation

3. Control of the airway, administration of 100% oxygen

4. Administration of intralipid

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Version 2009-2010 Resident’s Initials___________

8) A 22 month old child is admitted to the recovery area after having a CT guided aspiration of the left hip joint. He was sedated with ketamine and midazolam IV. He is transported to the recovery room on supplemental oxygen. On arrival to the recovery area his oximeter is noted to be reading 82%, and his lips are noted to be slightly blue.

1. Immediate actions include:

1. Give a detailed sign-out to the recovery personnel

2. Open the airway with a jaw thrust or chin lift

3. Draw up an appropriate dose of ondansetron, as this could be nausea

4. Assess the patient for respiratory effort

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

2. Possible causes of the patient’s desaturation include:

1. Laryngospasm

2. Upper airway obstruction

3. Hypoventilation from oversedation

4. Aspiration

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

3. Reasonable interventions include all of the following EXCEPT:

A. Suction of the oropharynx if it is noted to be full of secretions or emesis

B. Positive pressure ventilation if the patient’s respiratory effort is inadequate

C. Insertion of an oral or nasal airway if soft tissue relaxation is causing upper

airway obstruction

D. Administration of 0.1 mg/kg atropine to prophyactically treat bradycardia

E. Administration of CPAP if the airway obstruction is thought to be secondary

to laryngospasm

_______ SINGLE BEST ANSWER

After a jaw thrust opens his upper airway and stimulates him to take a few deep breaths his lips pink up and the oximeter is now reading 100%. Moments later he is crying uncontrollably.

4. His crying could be due to:

Version 2009-2010 Resident’s Initials___________

1. Pain

2. Hunger

3. Emergence delirium

4. Eosinophilic esophagitis secondary to reflux and aspiration

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

5. Emergence delirium:

1. Must be distinguished from hypoxia, hypoglycemia and/or pain

2. Occurs in about 15% of children after sedation

3. Most commonly occurs after a pure inhalational anesthetic or a ketamine

anesthetic

4. Will resolve spontaneously if untreated

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

6. True statements about the treatment of post-procedure pain include:

1. Both pain and the opioid medications used to treat pain can cause nausea

and vomiting

2. It is not necessary to monitor patients in a PACU setting if opiates are given

for emergence delirium rather than for pain

3. It is often difficult to distinguish between pain, hunger, anxiety and

emergence delirium in children

4. Most of the commonly used anti-emetics have analgesic properties

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

The patient is given 0.05 mg/kg morphine IV. After 5minutes he settles down and stops crying.

He gladly takes a popsicle. After eating about half of the popsicle, he vomits.

7. Post-procedure nausea and vomiting:

1. Can be associated with agents given for sedation

2. Can be associated with agents given for analgesia

3. Can be associated with premature introduction of oral fluids

4. Can be treated with ondansetron 0.1 mg/kg (up to 4 mg) IV

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

8. Serious complications during sedation/anesthesia occur secondary to

Version 2009-2010 Resident’s Initials___________

1. Inadequate monitoring for the level of sedation attained

2. Medication overdose

3. Inadequate skill of the practitioner performing the sedation

4. Inadequate guidelines for procedural sedation

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

9. The majority of reported serious complications during sedation/anesthesia occur in:

1. Patients with congenital heart disease

2. Patients with reactive airway disease

3. Patients with liver disease

4. Previously healthy children

Answer A if 1,2,and 3 are correct. Answer B if 1 and 3 are correct. Answer C if 2 and 4

_______ are correct. Answer D if 4 only is correct. Answer E if 1,2,3, and 4 are all correct

Download