CONCENTRATED GEMMOTHERAPY PSC FOR CHELATION OF ALL TOXIC METALS By, Dominique Richard, HMD, ND, CC The purpose of this article is to share an observation versus a full scale double blind study scientific paper. The observation and discoveries that I have made in the last ten years are so significant that it should merit further studies regarding a superior form of heavy metal chelation with Concentrated Gemmotherapy. "Heavy Metals"- A Meaningless Term Dr. John H. Duffus (Director, Edinburgh Centre for Toxicology, 43 Mansionhouse Road, Edinburgh, EH9 2JD, Scotland, UK Over the past two decades, the term "heavy metals" has been used increasingly in various publications and in legislation related to chemical hazards and the safe use of chemicals. It is often used as a group name for metals and semimetals (metalloids) that have been associated with contamination and potential toxicity or ecotoxicity. At the same time, legal regulations often specify a list of heavy metals to which they apply. Such lists may differ from one set of regulations to the other, or the term may be used without specifying which heavy metals are covered. In other words, the term "heavy metals" has been used inconsistently. This practice has led to general confusion regarding the significance of the term. The inconsistent use of the term "heavy metals" reflects inconsistency in the scientific literature. It is, therefore, necessary to review the usage that has developed for the term, paying particular attention to its relationship to fundamental chemistry. Without care for the scientific fundamentals, confused thought is likely to prevent advances in 1 scientific knowledge and to lead to bad legislation and to generally bad decision-making. Bjerrum's definition of heavy metals is based upon the density of the elemental form of the metal, and he classifies heavy metals as those metals with elemental densities above 7 g/cm3 . The term "heavy metal" has never been defined by any authoritative body such as IUPAC. Over the 60 years or so in which it has been used in chemistry, it has been given such a wide range of meanings by different authors that it is effectively meaningless. No relationship can be found between density (specific gravity) or any of the other physicochemical concepts that have been used to define heavy metals and the toxicity or ecotoxicity attributed to heavy metals. The term "heavy metal" has never been defined by any authoritative body such as IUPAC. Over the 60 years or so in which it has been used in chemistry, it has been given such a wide range of meanings by different authors that it is effectively meaningless. No relationship can be found between density (specific gravity) or any of the other physicochemical concepts that have been used to define heavy metals and the toxicity or ecotoxicity attributed to heavy metals. Understanding bioavailability is the key to assessment of the potential toxicity of metals and their compounds. Bioavailability depends on biological parameters and on the physicochemical properties of metals, their ions, and their compounds. These parameters, in turn, depend upon the atomic structure of the metals, which is systematically described by the periodic table. Thus, any classification of the metals to be used in scientifically based legislation must itself be based on the periodic table or on some subdivision of it. One possibility for such a system was suggested more than 20 years ago by Nieboer and Richardson when they also condemned the use of the term heavy metals. Such a 2 classification of metals by their Lewis acidity as Class A (hard), Class B (soft), or Borderline indicates the form of bonding in their complexes, and this designation determines the possibilities for complex formation and, thus, for toxicity E. Nieboer and D. H. S. Richardson. "The replacement of the nondescript term 'heavy metal' by a biologically and chemically significant classification of metal ions", Environmental Pollution (Series B), 1, 3 (1980). I have been a consultant and researcher in Gemmotherapy Pharmacology for the last 33 years and I am a firm believer of the “Phytosociology Physiology Analogue to the Human Body” / “Analogue Correlation between Plant and Human Anatomy and Physiology”. Plants and humans share numerous anatomical and physiological characteristics; we are actually more similar than different. Understanding these remarkable parallels gives us a greater appreciation for the kinship that exists between the plant and human realms. This in turn is the basis of reverence for nature and the respectful coexistence with biodiversity. It also provides an understanding of what plant detoxifies which chemicals, and proves their detoxifying powers and RNA repair, regenerating dying cells and correcting organ function for humans with Plant Stem Cells Therapy. The similarities between plants and humans can be simplified into three categories: 1) basic life needs, 2) anatomical and physiological characteristics, and 3) subtle functions. A wide range of environmental toxins can be remediated using plants. Phytoremediation is being used to clean up metals, pesticides, solvents, explosives, crude oil, polyaromatic hydrocarbons, and landfills. Hybrid poplar trees and Eastern cottonwood remove chlorinated solvents in 3 ground water. Petroleum and its hydrocarbons can be removed from soil and ground water using alfalfa, poplar and juniper, fescue grass, crabgrass, and clover. Polyaromatic hydrocarbons are remediated with ryegrass and mulberry trees. Heavy metals can be removed from soil using poplar and pine trees, vines, willows, chaparral, various grasses, and castor plants. Radionuclides can be removed from ground water with sunflowers and water hyacinth, and from the soil with mustards and cabbage. Explosives such as TNT can be removed from groundwater with duckweed and parrot feather grass. Nitrates can be remediated with cottonwood and poplar trees. Rye removes polyaromatic hydrocarbons. Various water plants, including hyacinths, are being used in municipal sewage treatment. Phytoremediation can be categorized into six basic plant functions: 1)phytodegradation,2)phytoextraction,3)rhizofiltration,4)rhizodegradation,5) phytostabilization, and 6)phytovolatilization. These functions are clear examples of the eco-physiology of plants and its practical applications for environmental remediation. Several comparisons can be made between these plant processes and human metabolic functions. Medicinal Plants Used in Eco-Restoration Several plants with important nutritional and phytochemical properties are being utilized in ecological restoration and environmental remediation. These species represent a unique category of phytoremeditation and plant eco-physiology: plants which benefit the environment while simultaneously providing food and medicine. Poplar Trees E.W. Aitchison, J.L. Schnoor, S.L. Kelley, and P.J.J. Alvarez, Department of Civil and Environmental Engineering, 125 4 Engineering Research Facility, 330 South Madison Street, The University of Iowa, Iowa City, IA 52242 1,4-dioxane, a suspected carcinogen, is widely used as a solvent in paints, varnishes, lacquers, cosmetics, and deodorants. It exists as a liquid at room temperature, is fully miscible in water, and is expected to be highly mobile in soil. Its half-life in soil and ground water is on the order of years, while its half-life in the atmosphere in the presence of NO and hydroxyl radicals is only 6.7-9.6 hours. Therefore, 1,4-dioxane volatilization into the atmosphere by plant transpiration could be a desirable result. In this research they have assessed the capacity of hybrid poplar trees (Populus deltoides nigra, DN34, Imperial Carolina) for uptake and translocation of 1,4-dioxane using l4C-labeled dioxane in hydroponics experiments. Plants can enhance the removal of xenobiotics by at least two mechanisms: (1) direct uptake and, in some cases, in-plant transformations to less toxic metabolites; and (2) stimulation of microbial activity and biochemical transformations in the root zone through the release of exudates and enzymes. Advantages of hybrid poplar trees as phytoremediation tools include: 1,4-dioxane was readily taken-up by the hybrid poplar tree cuttings from hydroponics solution. After 8 days, the following results were obtained: 30-79% (average = 54%) of the dioxane mass had been removed from the planted reactors 10% removed from the excised tree reactors 8% removed from the unplanted control Concentration of 1,4-dioxane remained relatively constant in all reactors, indicating that the compound may be freely diffusing into the plant via water osmosis. 5 Rapid uptake of phytoremediation 1,4-dioxane appear as an by hybrid attractive poplar trees alternative at makes dioxane- contaminated sites. Further research will examine poplar removal of 1,4dioxane from contaminated soil. Glutathione (GSH) and its derivatives play the major role in plant defense against these pollutants. Pesticides are detoxified by conjugation with GSH by glutathione S-transferase and subsequent excretion of these conjugates in the vacuoles. Heavy metals induce synthesis of a wide range of cysteine-rich peptides and proteins, including metallothioneins and phytochelatins (PC). The latter are synthesized enzymatically from glutathione, bind the metals with high affinity and the PC-metal complex is sequestered to the vacuole. Removes heavy metals, nitrates, chlorinated solvent and petroleum and its hydrocarbons. Willow Trees are famous for their love of water. They are usually found near rivers and streams and in low-lying areas. Willows can grow in water (wet feet) as long as the water contains enough oxygen. What is less obvious is the large uptake capacity of their root structure. Pursuant to these findings it was not difficult for me to deduct that perhaps the analogue correlation to human detoxification of heavy metals from the use of PSC Gemmotherapeutic Agents. Knowingly that Gemmotherapy first and foremost indication has to do with detoxification I started 10 years ago recommending them for the detoxification of heavy metals. Department scientist Terry McIntyre PUBLICATION: The Halifax ChronicleHerald. DATE Thursday June 10, 1999 6 According to Mr. McIntyre, certain plants - cat tails, elephant ears - and trees like alders, hybrid poplar, black locust, sweetgum, loblolly pine and juniper suck up certain pollutants into their root systems. They also help contaminated sites indirectly by changing the microbiotic structure of soil and water. EPA, 1996. Recent Developments for In Situ Treatment of Metal Contaminated Soils, EPA/542/R-96/008. Since 1996 the government of the united state started to introduce phytoremediation in the cleanup of contaminated soils. Phytoremediation List of Plants Arabidopsis & Willows Removes, Mercury & Heavy Metals Removes, Pesticides, Atrazine, Trichloroethylene (TCE), Trees in the Populus genus Black Poplar – Populus Nigra Carbon tetrachloride, Nitrogen compounds, 2,4,6trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5 triazine (RDX). Nitrates from fertilizers & Heavy Metals & Chlorinated Solvent. 1, 4-dioxan widely used as a solvent in paints, varnishes, lacquers, cosmetics and deodorants Perennial Rye – Polychlorinatedphenyls (PCP's), Secale Cereale polyaromatichydrocarbons (PAH's) Mustard Greens & Pumpkin & Grape Vines – Removes, Lead Vitis Vinifera Juniper – Removes, petroleum and its hydrocarbons 7 Juniperus Communis Mountain Pine – Pinus Montana Removes, Heavy Metals European Alder – Alnus Removes, Heavy Metals and Pesticides Glutinosa September 06, 2001 Biologists at the University of Pennsylvania have discovered the first biochemical pathway in animals responsible for the detoxification of heavy metals such as arsenic, mercury and cadmium. They have established that the enzyme phytochelatin synthase, which had previously been found only in plants and in some fungi, is also present in some animals. Phytochelatins have been known in plants as a means of detoxifying heavy metals for some 15 years. Phytochelatin synthase works by polymerizing glutathione, a sulfur-rich peptide with a high affinity for cadmium. The products of these reactions, phytochelatins, bind very strongly onto heavy metal atoms, immobilizing them and preventing them from moving to parts of the cell where their toxic effects are exerted. Source: Office of University Communications. June 15 issue of the Journal of Biological Chemistry. - By Steve Bradt In the last 10 years all patients from pediatric to geriatric population with positive 24 hour urine or positive hair analysis to heavy metals were given these PSC gemmotherapeutic agents and not to my surprise, all of them ended up with negative heavy metal screen be it, urine or hair analysis. Not only were the labs negative but also associated symptoms from cognitive to neurological afflictions, muscular symptoms, et cetera were greatly improved. A new way of detoxifying heavy metals out the 8 body was discovered without the side effects as in calcium EDTA or DMSA which both not only removes unwanted waste but also removes essential minerals out of the body causing all sorts of side effects as a result of such chelation. METAL TOXICITY Aluminum SOURCES Today, aluminum is everywhere under your arms (deodorants), in your teeth (toothpaste), and on your baby's skin (powder). In addition, dental amalgams, many cosmetics, and cigarette filters contain aluminum. We ingest it in some drinking waters, commercial teas, cheeses, white flour, baking powder, aspirin, and table salt. We cook with it too; most pots and pans are at least in part, made of aluminum. Unfortunately, many over-thecounter and prescription antacids for digestive difficulties, contain aluminum. Aluminum may also leach out of aluminum foil or cans into food and beverages. Sodas (with phosphoric acid), tomato sauce, pineapple, and coffee in aluminum cans are major culprits, as well as food wrapped in aluminum foil. Commercial tomato sauces are often prepared in huge aluminum pots and the acidity of the tomatoes can cause the leaching of aluminum from the cookware into the finished product. Coffee prepared in aluminum pots and pans may also be toxic. Heavy coffee drinkers may also be at risk another way. It is speculated that because coffee drinking causes an acidic reaction in the digestive tract, aluminum contained in any food or drug may become toxic or more toxic, because the acid will cause it to collect in the SYMPTOMS Elevated aluminum has been implicated for years in several brain diseases, such as Alzheimer’s and Parkinson’s disease and also found in some seniors with extreme memory loss, absentmindedness, or dementia. It is sometimes found in the hair of children diagnosed with ADHD, ADD, and those with seizures. Hyperactivity, memory disturbances, and learning disabilities may result from even mildly elevated levels of aluminum. Inhibition of neurotransmission and impaired motor coordination may also result. According to a report in the Lancet in 1989, many infant formulas contain aluminum. In this report it was revealed that human breast milk contained 5-20 micrograms per liter of aluminum, cow’s milk-based formulas contained 20 times as much aluminum, and soy-based formulas contained 100 times as much. So human breast milk had the lowest concentrations, proving to be the safest. Physical symptoms of aluminum toxicity may include brittle bones or osteoporosis, as aluminum is stored in the bones. Kidney malfunction may also result, as the kidneys filter aluminum. 9 bloodstream. There it can be carried to the brain along with the very blood that’s supposed nourish the brain cells. Arsenic toxicity includes ingestion of Arsenic arsenic (found in insect poisons), skin contact (e.g. some linseed oils) and even in drinking water. Nausea or vomiting, abdominal pain, diarrhea, headache, vertigo, fatigue, parasthesia, Cadmium Beer, chocolate, copper cookware, Copper copper IUD's, copper dental prosthesis, pipes, fungicides, hemodialysis and pressure emphysema, problems, kidney problems, prostate and other cancers, joint pain. Cadmium may demineralization promote and nuts, Migraine, emotional problems including depression, hyperactivity and schizophrenia (histapenia type), liver disease wastes, oysters, bone fragility and fracture risk. Cadmium can weaken the immune system and allow bacteria, viruses, yeast, and parasites to proliferate. Cadmium may also promote skeletal demineralization and increase bone fragility and fracture risk. Symptoms of cadmium toxicity include sore joints, decreased appetite, slow growth, zinc deficiency and kidney stones. insecticides, liver, milk, skeletal increase ice makers, industrial emissions, industrial mental impairment. Allergies, hair loss, colic. Blood The highest contributor to cadmium toxicity is cigarette smoke; it is found in cured tobacco. This is toxic for both the smoker and the nonsmoker. First hand and second hand smoke are high sources of cadmium. Other sources are well water, some soft water, evaporated milk, and some organ meats such as kidney and liver. Cadmium pipes can be a source, as well as fungicides sprayed on apples, tobacco, and potatoes. paralysis swimming pools, 10 water, city water, well water. problems, emotional utilized Learning metal in the U.S. It is mined disturbances, nervousness, anemia, extensively in Missouri Colorado anxiety, loss of appetite, headache, hair loss, epilepsy. Idaho and Utah and is used for convulsions, hypertension, fatigue, hemolytic anemia, the production of ammunition abdominal pain, nausea, constipation, bearing metals brass materials weight loss, peripheral neuropathy, cognitive dysfunction, arthralgia (joint solder ballasts tubes containers pains), headache, weakness, irritability, gasoline products ceramics and impotence, loss of libido, depression, decreased thyroid and adrenal function, weights (ATSDR 1993). Human chronic renal failure, gout. High lead exposure to lead occurs primarily levels have been found to be associated through drinking water airborne with ADHD, impulsivity, and an inability to inhibit inappropriate responses. lead-containing particulates and Hypertension, fatigue, hemolytic lead-based paints. Several anemia, abdominal pain, nausea, Lead Lead is the 5th most industrial processes create lead constipation, weight loss, peripheral dust/fumes resulting in its neuropathy, cognitive dysfunction, presence in the air. Mining arthralgia, headache, weakness, smelting manufacturing irritability, impotence, loss of libido, processes the burning of fossil depression, depression of thyroid and fuels gasoline) and (especially and lead-based adrenal function, chronic renal failure, municipal waste gout. and incorrect removal of leadbased paint results in airborne lead concentrations. After lead is airborne for a period of ten days it falls to the ground and becomes distributed in soils and 11 water sources (fresh and salt water surface and well water and drinking water). However the primary source of lead in drinking water is plumbing 1989). from lead-based materials The (U.S. corrosion EPA of such materials will lead to increased concentrations municipal of lead drinking water. in Lead from water and airborne sources have been shown to accumulate in agricultural areas leading to increased concentrations agricultural produce and in farm animals (ATSDR 1993). Cigarette smoke is also a significant source of lead exposure; people whom smoke tobacco or breathe in tobacco smoke may be exposed to higher levels of lead than people exposed to whom are cigarette not smoke (RAIS 1994). Manganese overload is generally Nervous due to Workers Manganese industrial in the Well water Symptoms of pollution. toxicity mimic those of Parkinson's manganese disease (tremors, stiff muscles) and processing industry are most at excessive risk. disorders. rich manganese intake can in cause hypertension in patients older manganese can be the cause of than 40. Significant rises in excessive manganese intake and manganese concentrations have been 12 can increase bacterial growth in found in patients with severe hepatitis water. Manganese poisoning has and post hepatic cirrhosis, in dialysis been found among workers in patients the battery and in patients suffering manufacturing heart attacks, Manganese has been industry. Everyone is exposed to known to cause the degenerative small amounts of manganese in brain disorder known as Parkinsonism air, water, and food. Exposure to since 1837. A recent study found 40 metal fumes from welding, cutting percent of welders showed signs of and brazing-especially in confined the disorder spaces-can cause brain damage. A major culprit is manganese, a component of all steel and major welding materials. Is a metal commonly found in Nervousness, rocks and environment, soil. In selenium is not diarrhea, somnolence, fall in blood Much of the selenium in rocks is death. respiratory failure Garlic-like combined with sulfide minerals or present nickel Selenium silver, copper, minerals. cough, the dyspnea, convulsions, abdominal pain, often found in the pure form. pressure, with vomiting, lead, on odor and may breath. be Selenium and oxychloride is a severe vesicant and Selenium and may cause oxygen combine to form several Accidentally fatal poisoning. swallowing a large compounds. Selenium sulfide is a amount of selenium (eg. a very large bright red-yellow powder used in quantity of selenium supplement pills) anti-dandruff shampoo. Industrially could be life threatening without produced hydrogen selenide is a immediate medical treatment. Chronic colorless gas with a disagreeable toxicity: marked pallor, garlic odor or odor and is probably the only breath, sweat and urine; red staining selenium compound that might of fingers, teeth and hair, marked pose a health concern in the debility, workplace. Selenium dioxide depression, is disturbances, epistaxis, dermatitis, irritation 13 G.I. of an industrially produced nose and throat. Hydrogen selenide compound that dissolves in water can cause pneumonitis and damage to form selenious acid. Selenious to liver and spleen. People may also acid is found in gun blueing (a lose feeling and control in the arms solution used to clean the metal and legs. parts of used as a gun). Selenium ingredient in is toning baths in photography; as pigment in manufacturing ruby-, pink, orange, or red-colored glass; as metallic base in making electrodes for arc lights, electrical instruments selenium and cells, apparatus, telephotographic apparatus; as coating in flame proofing electric cables; as vulcanizing agent in processing of rubber; as catalyst determination of Kjeldahl method; dehydrogenation compounds. in nitrogen by for of organic Although selenium can be toxic by itself, it also prevents the toxicity of several other metals mercury, such cadmium, as silver, and lead. Mercury causes the loss of the needed metals copper and zinc, and selenium helps to prevent that loss by binding the mercury. Mercury The source of mercury poisoning The onset time is one week or more, 14 is primarily contamination of food at by polluted mercuric water waste mercury weakness in and mercury-containing allergies, transmission of of the digestive tremors, infertility, psychosis, asthma, metal infertility. Chronic mercury exposure and toxicity can be very general and difficult to diagnose based on symptoms alone. In addition, individuals show varying levels of sensitivity to the presence of mercury: amalgam removal may be very important in the recovery process of one person, while for another it may be best to leave the amalgams in place. Discussion of iron toxicity in this protocol is limited to ingested or environmental exposure. overload Iron Iron disease (hemochromatosis), an inherited disorder, is not what we I am discussing here. Iron does not appear on the ASTDR's "Top 20 List," but it is a potential toxic metal of concern, legs, disorders, through both animal and cereal foods. the of some extreme symptoms of the poisoning. fungicides are a potential source depression, for symptoms organic are noted. Blindness and coma are fungicides. Food or feed grains Nervous with the from spastic paralysis and impaired vision or contained treated time containing numbness, compounds industrial which particularly 15 because ingesting dietary iron supplements may acutely poison young children (e.g., as few as five to nine 30-mg iron tablets for a 30-lb child). Other sources of iron are pipes, drinking and organs water, cookware. are cardiovascular iron Target the liver, system, and kidneys (Roberts 1999). Nickel is a very abundant element. In the environment, it is found oxygen primarily combined (oxides) with or sulfur (sulfides). It is found in all soils and is emitted from volcanoes. Pure nickel is a hard, silverywhite metal that is combined with other metals to form alloys. Some of the metals that nickel Nickel can be alloyed with are iron, copper, chromium, and zinc. making of metal coins and jewelry and in industry for These alloys are used in the making metal compounds are items. also Allergies, dermatitis, skin problems dizziness, as digestive disorders, cancer esp. lung cancer, apathy, vertigo. Lung effects, including chronic bronchitis and reduced lung function, have been observed in workers who breathed large amounts of nickel. Nickel used such for nickel plating, to color ceramics, to make some batteries, and as catalysts that increase the rate of chemical reactions. Nickel and its 16 compounds have no characteristic odor or taste. Nickel is required to maintain health in animals. A small amount probably of essential nickel for is humans, although a lack of nickel has not been found to affect the health of humans. Small nickel particles in the air settle to the ground or are taken out of the air in rain. Much of the nickel in the environment is found with soil and sediments because nickel attaches to particles that contain iron or manganese, which are often present sediments. in Nickel soil and does not appear to collect in fish, plants, or animals used for food. Major sources of exposure are: tobacco smoke, auto exhaust, fertilizers, super phosphate, food processing, hydrogenated-fats-oils, industrial cookware, waste, stainless testing of steel nuclear devices, tobacco smoke, baking powder, combustion of fuel oil, dental work and bridges. Chromium Chromium manufacturing is used in Breathing contaminated workplace air chrome-steel chrome-nickel-steel or (stainless steel welding, chromate or alloys chrome pigment production, chrome 17 (stainless steel) and other alloys, plating, leather tanning). Handling or bricks in furnaces, and dyes and breathing sawdust from chromium pigments, for greatly increasing treated wood. Breathing contaminated resistance and metals and leather tanning, preserving. durability chrome of air, or ingesting water, or food from plating, soil near waste sites or industries and wood that use Manufacturing, amounts chromium. of disposal of products or chemicals everyday containing chromium, or Very chromium foods. (III) All small are forms in of fossil chromium can be toxic at high levels, fuel burning release chromium to but chromium (VI) is more toxic than the air, soil, and water. chromium (III). Acute toxic effects occur when breathing very high levels of chromium (VI) in air that can damage and irritate your nose, lungs, stomach, and intestines. People who are allergic to chromium may also have asthma attacks after breathing high levels of either chromium (VI) or (III). Long term exposures to high or moderate levels of chromium (VI) cause damage to the nose (bleeding, itching, sores) and lungs, and can increase your risk of non-cancer lung diseases. amounts Ingesting of stomach chromium upsets very large can cause and ulcers, convulsions, kidney and liver damage, and even death. We don’t know if chromium harms ability to the reproduce. fetus or our Mice that ingested large amounts of chromium 18 had reproductive problems and defects. Skin offspring with birth contact with liquids or solids containing chromium (VI) may lead to skin ulcers. allergic Some reactions redness and Department of people have including severe swelling. The Health and Human Services has determined that certain chromium (VI) compounds are known carcinogens. increased workers This lung who chromium. indicate is cancer were Animal based in on some exposed studies chromium (VI) to also is a carcinogen. We do not have enough data to determine if chromium (0) or chromium (III) are carcinogens. Chromium can be measured in the hair, urine, serum, red blood cells, and whole blood. Tests more useful for high-level exposed people. Exact levels of exposure or how these levels will affect health cannot be inferred from tests. Chromium allergy may be detected by skin patch test. Just as within the eco-system phytoremediation proves to be analogue to the human body but further studies remains to be conducted. far as I can see all patients chelated with PSC But so Concentrated Gemmotherapy have benefited so much more than the presently available 19 forms of chelations. My findings remain not approved by the FDA nor fully validated by a full study but should be initiated to further study PSC Concentrated Gemmotherapy for the detoxification of heavy metals. Another consideration is that PSC Concentrated Gemmotherapy is a lot less expensive than presently available chelation agents and not invasive as with intravenous calcium EDTA chelation. And for the pediatric population the use of intravenous chelation is too traumatic. "There are 70,000 chemicals being used in commercial production in the U.S. The EPA has classified 65,000 of them potentially, if not definitely hazardous to human health" I predict that PSC Concentrated Gemmotherapy will become so popular in getting rid of toxicity versus the existing outdated methods of detoxification. Medical researcher, Alan Levine, M.D. believes that, "The vast increase of chemicals in our environment, foods and medicines has greatly altered the body's ability to rid itself of toxins." Chelation Therapy Today There are presently two known agents for the removal of heavy metals from the human body—calcium ethylenediamine tetra-acetic acid (EDTA) and meso 2, 3 dimercaptosuccinic acid (DMSA). Both are administered through chelation therapy, a series of intravenous infusions or oral intake intended to rid the body of toxic heavy metals and to protect against atherosclerosis and other serious health problems. Unfortunately, EDTA and DMSA also remove essential minerals from the body, making them less than ideal, especially for use in pediatrics. As with any chelating agent, DMSA can cause deficiencies of copper, manganese, molybdenum and zinc, if they are not replaced by supplementation. DMSA doesn’t directly bind detoxification magnesium, cysteine, or glutathione, can result in depletion of these but heavy nutrients as metal well. 20 References: Aposhian HV. DMSA and DMPS Water-soluble antidotes for heavy metal poisoning. Ann Rev Pharmacol Toxicol 1983; 23:193-215. There has been much research into other methods for chelation of heavy metals. Described here are observations of a different form of chelation called, PSC Concentrated Gemmotherapy (CG), which consists of 6 gemmotherapeutic agents that together remove heavy metals without removing other essential minerals. Table 1. Buds used in Gemmotherapy to removes heavy metals are Black Poplar – Populus Nigra (buds) These buds remove all heavy metals and chlorinated solvent, nitrates, 1, 4-dioxan (widely used as a solvent in paints, varnishes, lacquers, cosmetics and deodorants). It also removes petroleum and its hydrocarbons. Grape Vine – Vitis Vinifera (buds) these buds removes lead. Mountain Pine – Pinus Montana (buds) these buds removes all heavy metals Silver Birch – Betula Verrucosa (sap) has unique properties including the unparalleled ability to assist in the discharge of undesired waste matter from the human body. One tablespoon should be taken in the morning with other combined buds. White Willow – Salix Alba (buds) these buds removes mercury and other heavy metals. European Alder – Alnus Glutinosa (buds) these buds removes heavy metals, aluminum, and pesticides. Clinical Observations and Methods 21 The current clinical observations examine the use of PSC Concentrated Gemmotherapy for at least 6 months to treat heavy metal toxicity in adult and pediatric patients, suffering symptoms of heavy metal toxicity. The gemmotherapeutic agents in CG include 31 buds, 15 young shoots, 3 barks (in the embryonic stage), 3 rootlets, 1 seed (germinated), 1 male catkins flower, 1 flower, and 1 tree sap. But only 6 gemmotherapeutic agents get rid of heavy metals toxicity. The observation included adult and pediatric patients. Silver Birch sap was often added, for its unparalleled ability to assist in the discharge of undesired waste matter, from the human body. References: Materia Medica Plant Stem Cells Therapy, Dr. Richard 2005. Birch trees are known to be active in cleaning the kidneys of waste and of correcting kidney function. When using birch, which has diuretic activity, potassium levels do not have to be checked since all birch contains 30% potassium therefore making it an ideal diuretic. Some 50 patients of all ages with positive urine screens for various heavy metals. Adults were given 3 drops TID for each heavy metal for which they tested positive. Patients received drops for a minimum of six months. The dosage for children was 2 drops per heavy metal, taken TID. The therapy proved successful at improving symptoms of heavy metal toxicity and/or at achieving negative urine screens in 100% of patients. Most patients required therapy for a minimum of 6 months, although some patients needed to continue therapy for up to one year to further improve associated symptoms. Some patients now still test negative for heavy metals. Among children with ADHD and autism, there has been significant improvement in health and mental IQ, cognitive functions; inattentive, hyperactive-compulsive and these children are no longer showing symptoms of autism, or of ADHD. These results are unprecedented and should encourage further consideration for this type of therapy. In addition to the efficacy of CG, this study showed that the duration of therapy may require only 6 months to 1 year, as opposed to 22 the 2 years it normally takes with EDTA or DMSA. References: Aposhian H, Maiorino R, Rivera M, et al. Human studies with the chelating agents, DMPS and DMSA. J Toxicol Clin Toxicol 1992, 30:505-528. PSC Concentrated Gemmotherapy versus 1DH Diluted Gemmotherapy The use of concentrated gemmotherapy holds advantages over 1DH diluted gemmotherapy. A problem with 1DH gemmotherapeutic methods for chelation of heavy metals is the amount of alcohol that is ingested with this first decimal (1DH) dilution dosage. While CG requires only 3 drops three times per day, the required 1DH potency gemmotherapy dosage requires 50 drops 3 times per day. CG is prepared through a maceration process using water, alcohol and vegetable glycerine. This is the process developed by the creator of gemmotherapy, Dr. Pol Henry, who insisted on the need for water, as the only way to extract and dissolve water-based principal vitamins and acids, as well as most flavonoids, mineral salts, and tannins. The 1DH Diluted gemmotherapy dosage does not contain water which essential for extracting mineral salts; and the ingestion of unnecessary alcohol adds unnecessary stress to an already overburdened system, and can have a negative impact on brain development in pediatric patients. References: AMA report on alcohol’s adverse effects on the brains of children, adolescents and college students Oct 20, 2004. In addition to using no water in the process, the 1DH initial maceration process uses References: frozen buds which lose 10% of their effectiveness. Skrede G; Fruits. Jeremiah LE; Freezing Effects on Food Quality. New York, NY, Marcel Dekker, Inc.; 1996: 183-246. The buds are frozen so they can be macerated as needed for the thousands of extracts produced in homeopathic laboratories. Gemmotherapy is most effective when it comes from freshly macerated buds. The 1DH dilution came about as part of an attempt to make a gemmotherapeutic product 23 into a homeopathic product, which it is not. Gemmotherapy belongs to the field of phytotherapy, based on its use of phytochemical constituents. Discussion Contrary to popular belief, Phytotherapy is not effective in the removal of heavy metals since it has had the time to accumulate toxins (such as heavy metals) from the ground and atmosphere they clean. The quality and consistency varies greatly among manufacturers. The results of these observations are unprecedented and should encourage further consideration of PSC Concentrated Gemmotherapy in the treatment of heavy metal toxicity in adult and pediatric patients. In addition to the efficacy of CG, these observations has demonstrated that the duration of therapy may require only 6 months to 1 year, as compared to the 2 years it usually requires with EDTA or DMSA. Nevertheless, further studies that rely on blood tests, to substantiate the efficacy of natural therapeutics, including PSC Concentrated Gemmotherapy, are forthcoming. About Gemmotherapy PSC Concentrated Gemmotherapy contains two major growth hormones, Auxins and Gibberellins, which repair RNA and contains also plant stem cells called meristems. PSC Concentrated Gemmotherapy also contains vitamins, enzymes, oligo-elements, tannins, flavonoids, phenols, quercetin, myricetine, nucleic acids, and antioxidants. It is the most active part of a plant since it contains all of the genetic information of the future plant that, once the plant matures, are no longer there. It detoxifies, oxygenates, rejuvenates and nourishes the cells, and much like stem cells, works on regulating the function of organs and glands by removing “body’s burden”, therefore regaining its function - a true regenerative 24 medicine. The process of detoxification is achieved by tissue excitation and the enzyme phytochelatin synthase. Dr. Dominique Richard obtained his medical degree from the University of Paris Sud and continued his education for three more years at The Society Biotherapy in Paris. He has been a consultant for the last 34 years in natural pharmacology, pharmacokinetics, research, development, and protocols. He is about to publish two novels: One titled “ Materia Medica Plant Stem Cells Therapy”, a twelve hundred eighty five page textbook as well as a layman’s book titled “Aging Is Not An Option”, St. Martin’s Press publisher. 25