Cellular and Molecular Medicine Division
Wen-Hwa Lee 李文華
Distinguished Visiting Scholar
特聘講座
whlee@uci.edu
Selected Publications

Lee, W. H.; Bookstein, R.; Hong, F.; Young, L. J.; Shew, J. Y.; Lee, E., Human Retinoblastoma
Susceptibility Gene - Cloning, Identification, and Sequence. Science 1987, 235, 1394-9.

Lee, W. H.; Shew, J. Y.; Hong, F. D.; Sery, T. W.; Donoso, L. A.; Young, L. J.; Bookstein, R.;
Lee, E., The Retinoblastoma Susceptibility Gene Encodes a Nuclear Phosphoprotein Associated
with DNA-Binding Activity. Nature 1987, 329, 642-5.

Huang, H. J. S.; Yee, J. K.; Shew, J. Y.; Chen, P. L.; Bookstein, R.; Friedmann, T.; Lee, E.; Lee,
W. H., Suppression of the Neoplastic Phenotype by Replacement of the Rb Gene in Human
Cancer-Cells. Science 1988, 242, 1563-6.

Lee, E.; To, H.; Shew, J. Y.; Bookstein, R.; Scully, P.; Lee, W. H., Inactivation of the
Retinoblastoma Susceptibility Gene in Human-Breast Cancers. Science 1988, 241, 218-21.

Chen, P. L.; Scully, P.; Shew, J. Y.; Wang, J. Y. J.; Lee, W. H., Phosphorylation of the
Retinoblastoma Gene-Product Is Modulated During the Cell-Cycle and Cellular-Differentiation.
Cell 1989, 58, 1193-8.

Bookstein, R.; Shew, J. Y.; Chen, P. L.; Scully, P.; Lee, W. H., Suppression of Tumorigenicity of
Human Prostate Carcinoma-Cells by Replacing a Mutated Rb Gene. Science 1990, 247, 712-5.

Chen, P. L.; Chen, Y. M.; Bookstein, R.; Lee, W. H., Genetic Mechanisms of Tumor Suppression
by the Human P53 Gene. Science 1990, 250, 1576-80.

Goodrich, D. W.; Wang, N. P.; Qian, Y. W.; Lee, E.; Lee, W. H., The Retinoblastoma
Gene-Product Regulates Progression through the G1 Phase of the Cell-Cycle. Cell 1991, 67,
293-302.

Goodrich, D. W.; Lee, W. H., Abrogation by C-Myc of G1 Phase Arrest Induced by Rb Protein
but Not by P53. Nature 1992, 360, 177-9.

Lee, E.; Chang, C. Y.; Hu, N. P.; Wang, Y. C. J.; Lai, C. C.; Herrup, K.; Lee, W. H.; Bradley, A.,
Mice Deficient for Rb Are Nonviable and Show Defects in Neurogenesis and Hematopoiesis.
Nature 1992, 359, 288-94.

Bignon, Y. J.; Chen, Y. M.; Chang, C. Y.; Riley, D. J.; Windle, J. J.; Mellon, P. L.; Lee, W. H.,
Expression of a Retinoblastoma Transgene Results in Dwarf Mice. Genes Dev 1993, 7,
1654-62.

Shan, B.; Lee, W. H., Deregulated Expression of E2f-1 Induces S-Phase Entry and Leads to
Apoptosis. Mol Cell Biol 1994, 14, 8166-73.

Chen, P. L.; Riley, D. J.; Chen, Y. M.; Lee, W. H., Retinoblastoma protein positively regulates
terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev 1996, 10,
2794-804.

Liu, C. Y.; FleskenNikitin, A.; Li, S.; Zeng, Y. Y.; Lee, W. H., Inactivation of the mouse Brca1
gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation
development. Genes Dev 1996, 10, 1835-43.

Riley, D. J.; Nikitin, A. Y.; Lee, W. H., Adenovirus-mediated retinoblastoma gene therapy
suppresses spontaneous pituitary melanotroph tumors in Rb-+/- mice. Nat Med 1996, 2,
1316-21.

Shan, B.; Durfee, T.; Lee, W. H., Disruption of RB/EBF-1 interaction by single point mutations
in E2F-1 enhances S-phase entry and apoptosis. Proc Nat Acad Sci USA 1996, 93, 679-84.

Chen, P. L.; Chen, C. F.; Chen, Y. M.; Xiao, J.; Sharp, Z. D.; Lee, W. H., The BRC repeats in
BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
Proc Nat Acad Sci USA 1998, 95, 5287-92.

Chen, C. F.; Chen, P. L.; Zhong, Q.; Sharp, Z. D.; Lee, W. H., Expression of BRC repeats in
breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity
and loss of G(2)/M checkpoint control. J Biol Chem 1999, 274, 32931-5.

Utomo, A. R. H.; Nikitin, A. Y.; Lee, W. H., Temporal, spatial, and cell type-specific control of
Cre-mediated DNA recombination in transgenic mice. Nat Biotech 1999, 17, 1091-6.

Zhong, Q.; Chen, C. F.; Li, S.; Chen, Y. M.; Wang, C. C.; Xiao, J.; Chen, P. L.; Sharp, Z. D.; Lee,
W. H., Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage
response. Science 1999, 285, 747-50.

Li, S.; Ting, N. S. Y.; Zheng, L.; Chen, P. L.; Ziv, Y.; Shiloh, Y.; Lee, E.; Lee, W. H., Functional
link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 2000,
406, 210-5.

Zheng, L.; Chen, Y. M.; Riley, D. J.; Chen, P. L.; Lee, W. H., Retinoblastoma protein enhances
the fidelity of chromosome segregation mediated by hsHec1p. Mol Cell Biol 2000, 20, 3529-37.

Zheng, L.; Pan, H. Y.; Li, S.; Flesken-Nikitin, A.; Chen, P. L.; Boyer, T. G.; Lee, W. H.,
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger
protein, ZBRK1. Mol Cell 2000, 6, 757-68.

Zheng, L.; Annab, L. A.; Afshari, C. A.; Lee, W. H.; Boyer, T. G., BRCA1 mediates
ligand-independent transcriptional repression of the estrogen receptor. Proc Nat Acad Sci USA
2001, 98, 9587-92.

Yang, H. J.; Jeffrey, P. D.; Miller, J.; Kinnucan, E.; Sun, Y. T.; Thoma, N. H.; Zheng, N.; Chen, P.
L.; Lee, W. H.; Pavletich, N. P., BRCA2 function in DNA binding and recombination from a
BRCA2-DSS1-ssDNA structure. Science 2002, 297, 1837-48.

Zhong, Q.; Boyer, T. G.; Chen, P. L.; Lee, W. H., Deficient nonhomologous end-joining activity
in cell-free extracts from Brca1-null fibroblasts. Cancer Res 2002, 62, 3966-70.

Furuta, S.; Jiang, X. Z.; Gu, B. N.; Cheng, E.; Chen, P. L.; Lee, W. H., Depletion of BRCA1
impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Nat Acad
Sci USA 2005, 102, 9176-81.

Furuta, S.; Wang, J. M.; Wei, S. Z.; Jeng, Y. M.; Jiang, X. Z.; Gu, B. N.; Chen, P. L.; Lee, E.;
Lee, W. H., Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to
accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell 2006,
10, 13-24.

Poole, A. J.; Li, Y.; Kim, Y.; Lin, S. C. J.; Lee, W. H.; Lee, E., Prevention of Brca1-mediated
mammary tumorigenesis in mice by a progesterone antagonist. Science 2006, 314, 1467-70.