1
SUDHA SESHADRI, MBBS, MD, DM
Current Designation:
Address:
Associate Professor, Department of Neurology,
Co-Director of Medical Education for Residency Program,
Boston University School of Medicine
Investigator, The Framingham Heart Study
715 Albany Street, Room B 602, Boston, MA 02118
Phone: 617-414-1337; Fax: 617-638-8086; Email: suseshad@bu.edu
ACADEMIC TRAINING:
Doctor of Medicine
(D.M.)-Neurology
All India Institute of Medical Sciences,
New Delhi, India
1992
Doctor of Medicine
(M.D.)- Medicine
All India Institute of Medical Sciences,
New Delhi, India
1988
Bachelor of Medicine,
Bachelor of Surgery
(M.B.B.S.)
Christian Medical College, Vellore &
Madras Medical College, Madras,
Madras University, India.
1986
POST_DOCTORAL TRAINING:
Residency: Internship in Internal Medicine (2001-2002) and Residency in Neurology (2002-2005),
Boston Medical Center, Boston, MA. (Chief Resident, July 2004 to June 2005)
1986-1988: Junior Resident, Internal Medicine, All India Institute of Medical Sciences, New Delhi, India
(Residency training in Internal Medicine)
1989: Senior Resident (Registrar), Dept. of Internal Medicine & Research Officer, Dept. of Neurology,
AIIMS, New Delhi
1990-1992: Senior Resident, Neurology, AIIMS, New Delhi, India. (Residency training in Neurology)
July 1993 to April 1996: Fellow in Neurology, University of Massachusetts Medical Center, Worcester,
MA, U.S.A.
October 1998 to April 2001: Post-doctoral Fellow, Department of Neurology, Boston University School
of Medicine, Boston, MA and Investigator, Framingham Heart Study, Framingham, Massachusetts, U.S.A.
Medical Licensure: Massachusetts (#209711); Medical Council of India (#29797)
Board Certification: Diplomate of the American Board of Psychiatry and Neurology (2006) #53876
Academic Appointments
April 1996 to April 1998: Assistant Professor of Neurology (tenured, full time), AIIMS, New Delhi, India
April 1998 to September 1998: Assistant Professor of Neurology (tenured, full time), Sree Chitra
Thirunal Institute of Medical Science and Technology, Trivandrum, Kerala, India.
May 2001 to May 2007: Assistant Professor, Department of Neurology, Boston University
May 2007 onwards: Associate Professor, Department of Neurology, Boston University, Boston
Additional responsibilities include Co-Director of Medical Education for Residency Program and
2
Investigator, Framingham Heart Study.
Hospital Appointments:
Attending Faculty (Assistant Professor) in Neurology, All India Institute of Medical Sciences, New
Delhi, India
April 1998 to Sept 1998: Faculty (Assistant Professor) in Neurology, Sree Chitra Thirunal Institute of
Medical Science and Technology, Trivandrum, Kerala, India.
July 2005 onwards: Attending Neurologist; full clinical privileges since July 2005.
May 2007 onwards: Associate Professor, Department of Neurology, Boston University
Honors/Awards
National High School Science Talent Scholar; Community Orientation Program Prize for best
undergraduate rural health project; Thomas Dina Prize for Physiology; Dhananjay Abhyankar Memorial
Award for best undergraduate research essays in Physiology; George Chacko Memorial Award for
Excellence in Preclinical Sciences; Dr. A. Venugopal Medal in Urology, E. Merck Gold Medal in
Neurology and Allied Sciences (Neurological Society of India), Boston University Department of
Neurology Resident Award for Excellence in Teaching (2006); Department of Neurology Resident Award
for Outstanding Dedication to Resident Education (2007), Marquis Who’s Who 2008.
Professional Societies: Member: American Academy of Neurology (also member of Neuroepidemiology,
Stroke, Neurogenetics and Geriatric subsections); American Stroke Association; Scientific Council of
American Stroke Association, American Medical Association; Massachusetts Medical Society; World
Federation of Neurology; Alzheimer’s and Related Disorders Society of India; Neurological Society of
India, Indian Academy of Neurology, Indian Epilepsy Society, Alpha Omega Alpha.
Committee Responsibilities: Graudate Medical Education (Neurology); Leader Neurogenetics and
Dementia End-Points Review Committees; Member 100K Publications and Steering Committees, SHARe
Replication and Scientific Committees for the Framingham Heart Study, Dean's Junior Faculty Committee
for the Development of Strategic Missions, Goals and Objectives at Boston University School of Medicine.
NIA Alzheimer’s Disease Genetics Planning Work Group; AAN Scientific Abstract Review Committee
2008
Reviewer for Neurology, Circulation, Diabetes Care, Journal of Neurological Sciences, Journal of
Neurology, Journal of Geriatric Neurology and Psychiatry, Clinical Chemistry and Laboratory Medicine,
BMC Neurology; Neuroscience and Biobehavioral Reviews, Stroke, Lancet Neurology.
Associate Editor: Journal of Alzheimer Disease.
3
INVITED LECTURES:
Date
2007
Occasion/Venue
American Diabetes Association
Topic
Link Between Alzheimer’s Disease and Diabetes- Is there
a Correlation?
2007
American Academy of Neurology:
Contemporary Clinical Issues
Plenary Session
Genetic Correlates of Brain Aging on MRI and Cognitive
Test Measures: Genome Wide Association Analyses in
the Framingham Heart Study.
2006
Presentation to Alzheimer's Advisory
Board at Boston University School
of Medicine
Diabetes, Obesity and Insulin Resistance. How do they
alter the risk and severity of Alzheimer's Disease?
2006
Boston Stroke Society Meeting,
Keynote Speaker
Vascular Dementia and Vascular Cognitive Impairment:
Insights from the Framingham Study
2005
Boston University Alzheimer’s
Disease Center Grand Round
Homocysteine in Brain Aging and Dementia: Insights
from the Framingham Study
2004
Dept. Of Neurology, Grand Round,
Boston Medical Center
Dementia: Potential Pathways to Primary and Secondary
Prevention.
2003
Dept. Of Neurology, Grand Round,
Boston Medical Center
Homocysteine and the Brain: Insights from the
Framingham Study
Dept. of Clinical Pathology Grand
Round, Brigham and Women’s
Hospital
Homocysteine and the Brain: Risk of Developing
Alzheimer’s Disease and Dementia
1999
General Federation of Women’s
Clubs of Massachusetts
Contributions of the Framingham Study to Women’s
Health, Heart Disease and Dementia
1998
14th International Conference of
Alzheimer’s Disease International
Caregiving for People with Dementia: ‘Eastern needs are
different and unique solutions are needed.’
Third International Symposium and
Workshop on Sleep DisordersISWSD 98
Sleep in Dementia, Parkinson’s disease, Stroke and other
selected neurological disorders
Clinical profile of dementia
National Symposium on Dementia
and Cognitive Neurology
Non-Alzheimer degenerative dementias- a clinical
approach
An approach to the differential diagnosis and
management of dementia in adults
1997
1994
All India Radio, Delhi
Management of Epilepsy (live interactive session)
National Workshop on Management
of Common Neurological Disorders
Approach to a patient with meningitis
Symposium on Brain Aging
Current Management of Dementia
Continuing Medical Education
Program for General Practitioners
Management of Migraine and other Headaches
Public lecture at the Sundaram
Medical Foundation, Madras.
Importance of Clinical Epidemiology
4
BIBLIOGRAPHY
Original peer reviewed publications
1.
Vasan RS, Seshadri S, Narula J. Atrial Natriuretic Peptide- an atavistic hormone? Int J Cardiol
1989; 22: 407-408.
2.
Vasan RS, Seshadri S, Narula J. ANP - Effect yes, role no. Int J Cardiol 1989; 25: 142.
3.
Seshadri S, Jain S, Maheshwari MC. Rehabilitation in multiple sclerosis. Indian J Disability and
Rehabilitation 1990; July-December: 31-43.
4.
Vasan RS, Seshadri S. Is the routine chest X-ray necessary? Natl Med J of India 1991;4: 205.
5.
Seshadri S, Narula J, Chopra P. Asymptomatic eosinophilic myocarditis: 2+2=4 or 5? Int J
Cardiol 1991;31: 348-349
6.
Seshadri S, Vasan RS, Vijayakumar M, Reddy KS, Ahuja GK, Shrivastava S. Comprehensive
evaluation of cardiac function in myasthenia gravis. Neurology India 1991; 39: 169-174.
7.
Behari M, Singh KK, Seshadri S, Prasad K, Ahuja GK. Botulinum toxin in blepharospasm and
hemifacial spasm. J Assoc Phy Ind 1994; 42(3): 205-208.
8.
Seshadri S, Jain S, Maheshwari MC. Neurological manifestations of AIDS. J Assoc Phy Ind
1994; 42(4): 309-310,315.
9.
Seshadri S, Drachman DA, Lippa CF. Apolipoprotein E and the lifetime risk of Alzheimer's
disease: What physicians know and what they should know. Arch Neurol 1995;52:1074-1079.
10.
Seshadri S, Wolf PA, Beiser A, Au R, McNulty K, D’Agostino RB. Lifetime risk of dementia and
Alzheimer’s disease: The impact of mortality on risk estimates in the Framingham Study.
Neurology 1997;49:1498-1504.
11.
Tandon R, Khanna S, Sharma MC, Seshadri S, Menon V. Subacute sclerosing panencephalitis
presenting as optic neuritis. Indian J Ophthalmol. 1999 Dec;47: 250-2.
12.
Beiser A, D’Agostino RB, Seshadri S, Sullivan LM, Wolf PA. Computing estimates of incidence,
including lifetime risk: Alzheimer’s disease in the Framingham Study. The Practical Incidence
Estimators (PIE) macro. Statistics in Medicine 2000;19: 1495-1522.
13.
Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Statins and the risk of dementia.
Lancet 2000;356:1627-31.
14.
Seshadri S, Zornberg GL, Derby LE, Myers MW, Jick H, Drachman DA. Postmenopausal
estrogen replacement therapy and the risk of Alzheimer’s disease. Arch Neurol 2001;58:435-440.
15.
Tripathi M, Seshadri S, Padma MV, Jain S, Maheshwari MC, Behari M. Serum cobalamin levels
in dementias. Neurology India 2001:49:284-6.
16.
Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Dementia and statins- reply [letter].
Lancet 2001;357: 880-881.
17.
Seshadri S, Wolf PA, Beiser A, Vasan RS, Wilson PW, Kase CS, Kelly-Hayes M, Kannel WB,
D'Agostino RB. Elevated midlife blood pressure increases stroke risk in elderly persons: The
Framingham Study. Arch Intern Med. 2001;161: 2343-50.
18.
Zhang Y, Seshadri S, Ellison RC, Heeren T, Felson DT. Bone mineral density and verbal memory
impairment: Third National Health and Nutrition Examination Survey. Am J Epidemiol.
2001;154:795-802.
19.
Vasan RS, Massaro JM, Wilson PW, Seshadri S, Wolf PA, Levy D, D'Agostino RB. Antecedent
blood pressure and risk of cardiovascular disease: the Framingham Heart Study. Circulation.
2002;105:48-53.
20.
Vasan RS, Beiser A, Seshadri S, Larson MG, Kannel WB, D'Agostino RB, Levy D. Residual
lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart
Study. JAMA 2002; 287:1003-10.
21.
Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf
5
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PA. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med.
2002;346: 476-83.
Seshadri S, Wolf PA. Homocysteine and dementia – Reply. N Engl J Med 2002; 346: 2008.
Tan ZS, Seshadri S, Beiser A, Wilson PW, Keil DP, Tocco M, D’Agostino RB, Wolf PA. Plasma
cholesterol level as a risk factor for Alzheimer’s disease: the Framingham Study. Arch Intern Med
2003; 163:1053-7.
Elias MF, Sullivan LM, D’Agostino RB, Elias PK, Beiser A, Au R, Seshadri S, DeCarli C, Wolf
PA. Framingham Stroke Risk Profile and Lowered Cognitive Performance. Stroke 2004;35: 404409.
Ivan CS, Seshadri S, Beiser A, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Dementia after stroke:
The Framingham Study. Stroke 2004;35: 1264-69.
Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D'Agostino RB, DeCarli C. Stroke risk
profile predicts white matter hyperintensity volume: the Framingham Study. Stroke 2004;35:
1857-61.
Seshadri S, Wolf PA, Besier A, Elias MF, Au R, Kase CS, D’Agostino RB, DeCarli C. Stroke
Risk Profile, Brain Volume and Cognitive Function: The Framingham Offspring Study. Neurology
2004;63: 1591-99.
Seshadri S, Beiser A, Ivan CS, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Does preventing stroke
prevent all kinds of dementia? Response. Stroke 2004;35: 2437.
Au R, Seshadri S, Wolf PA, Sullivan L, D’Agostino RB. New Norms for a new generation:
cognitive performance in the Framingham Offspring Cohort.Experimental Aging Research
2004;30: 333-358.
Zaldy ST, Seshadri S, Beiser A, et al. Bone mineral disease and the risk of Alzheimer’s disease.
Arch Neurol 2005;62: 107-111.
Ellias MF, Sullivan LM, D’Agostino RB, Elias PK, Jacques PF, Selhub J, Seshadri S, Au R,
Beiser A, Wolf PA. Homocysteine and cognitive performance in the Framingham Offspring
Study: age is important. Am J Epidemiol 2005;162:644-53.
Seshadri S, Beiser A, et al. Lifetime risk of stroke and dementia. Stroke 2006; 37(2):345-50.
Au R, Massaro JM, Wolf PA, Young ME. Beiser AS, Seshadri S, D'Agostino RB, DeCarli C.
Association of white matter hyperintensity volume with cognitive functioning- The Framingham
Heart Study. Arch Neurol 2006;63:246-250.
Elias MF, Sullivan LM, Elias PK, Vasan RS, D’Agostino RB, Seshadri S, Au R, Wolf PA,
Benjamin EJ. Atrial fibrillation is associated with lower cognitive performance in the Framingham
Offspring men. Journal of Stroke and Cerebrovascular Diseases 2006;15:214-222.
McKee AC, Au R, Cabral HJ, Kowall NW, Seshadri S, Kubilus CA, Drake J, Drake BS, Wolf
PA. Pathological involvement of the visual association cortex in cognitively intact, mildly
impaired and demented subjects with Alzheimer’s Disease. Neuropathol Exp Neurol.
2006;65:621-30.
Akomolafe A, Beiser AS, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S. Diabetes
mellitus and risk of developing Alzheimer’s dementia: results from the Framingham Study. Arch
Neurol 2006; 63:1551-5.
Carandang R, Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA. Temporal
trends in incidence, lifetime risk, severity and mortality of stroke over the past fifty years. JAMA
2006;296:2939-46.
MF Elias, LM Sullivan, EJ. Benjamin, PK Elias, RB D’Agostino, Sr., PA Wolf, Seshadri S, Au
R, Vasan RS. Left Ventricular Mass, Blood Pressure and Lowered Cognitive Performance in the
Framingham Offspring. Hypertension. 2007;49:439-45.
6
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44.
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46.
Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan R, Larson MG, Meigs JB, Keaney
JF, Lipinska I, Kathiresan S, Benjamin EJ, DeCarli C.Inflammatory Biomarkers are Associated
with Total Brain Volume: The Framingham Heart Study. Neurology 2007;68:1032-1038.
Wolf PA, Beiser A, Elias MF, Au R, Vasan RS, Seshadri S. Relation of Obesity to Cognitive
Function: Importance of Central Obesity and Synergistic Influence of Concomitant Hypertension.
The Framingham Heart study. Current Alzheimer Research 2007;4:111-116.
Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, Benjamin EJ, Au R, Kiel
DP, Wolf PA, Seshadri S. Inflammatory markers and the risk of Alzheimer’s disease: The
Framingham Study. Neurology 2007;68:1902-1908.
Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, Kelly-Hayes M, Kase CS, D’Agostino
RB, DeCarli C, Atwood LD, Wolf PA. Genetic correlates of brain aging on MRI and cognitive test
measures: a genome wide association and linkage analysis in the Framingham study. BMC Med
Genet 2007, 8 (Suppl 1): S15 http://www.biomedcentral.com/1471-2350/8/S1/S15.
Larson MG, Atwood LD, Benjamin EJ, Cupples LA, D’Agostino RB, Sr., Fox CS, Diddahally
RG, Guo CY, Heard-Costa NL, Hwang SJ, Lunetta KL, Murabito JM, Newton-Cheh C,
O’Connor GT, O’Donnell CJ, Seshadri S, Vasan RS, Wang TJ, Wolf PA, Levy D. Framingham
Heart Study 100K Project: Genomewide Associations for Cardiovascular Disease Outcomes. BMC
Med Genet 2007, 8 (Suppl 1): S5. http://www.biomedcentral.com/1471-2350/8/S1/S5
Lunetta KL, D’Agostino, RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, KellyHayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM. Genetic Correlates of Longevity
and Selected Age-related Phenotypes: Genome-wide Association Study in the Framingham Study.
BMC Med Genet 2007, 8 (Suppl 1): S13. http://www.biomedcentral.com/1471-2350/8/S1/S13.
Cupples LA, Arruda H, Benjamin EJ, D'Agostino Sr RB, Demissie S, Destefano AL, Dupuis J,
Falls K, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa N, Hwang SJ, Kathiresan
S, Kiel DP, Larson MG, Laramie JM, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK,
Meigs JB, Murabito JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ, Pandey MA, Qiong Y,
Seshadri S, Vasan RS, Wilk JB, Wolf PA, Atwood LD: The Framingham Heart Study 100K SNP
genome-wide association study resource: Overview of 17 phenotype working group reports. BMC
Med Genet 2007, 8 (Suppl 1): S1. http://www.biomedcentral.com/1471-2350/8/S1/S1.
Seshadri S, Wolf PA, Besier A, Au R, Selhub J, Jacques PF, Rosenberg IH, D’Agostino RB,
DeCarli C. Association of elevated plasma homocysteine levels with subclinical brain injury:
relation to silent brain infarcts, white matter hyperintensity and MRI brain volume in the
Framingham Offspring. Arch Neurol 2007 [in press].
Invited Reviews
47.
48.
49.
50.
51.
Seshadri S, Wolf PA. Homocysteine and the brain: vascular risk factor or neurotoxin? [Reflection
and Reaction]. Lancet Neurology 2003;2:405.
Seshadri S. Selected Summary: Nucleic acid amplification tests for tuberculous meningitis. A
systematic review of diagnostic accuracy. Natl Med J India 2003;16: 260-261.
Seshadri S. Methodology for measuring cerebrovascular disease burden. Int Rev Psych
2006;37:345-50
Seshadri S. Elevated plasma homocysteine levels: risk factor or risk marker for the development
of dementia and Alzheimer’s disease? J Alz Dis 2006;9:393-8.
Seshadri S, Wolf PA. Lifetime Risk of Stroke. Lancet Neurology 2007 [in press, expected Dec].
7
TEXTBOOKS
Vasan RS, Seshadri S. Textbook of Internal Medicine. Orient Longman, Madras, India. 1998.
[Selected by the National Book Trust of India for subsidization].
Vasan RS, Seshadri S. Medicine at a glance- A companion to the ‘Textbook of Internal
Medicine.’ Orient Longman, Madras, India. 1998.
CHAPTERS
Seshadri S, Drachman DA. Aging and dementia: Principles, evaluation and diagnosis. Pages 237251. In Asbury AK, McKhann G, McDonald WI, Goadsby PJ, McArthur JC, eds., Diseases of the
Nervous System: Clinical Neuroscience and Therapeutic Principles. 3rd Ed. Cambridge University
Press, Cambridge, U.K.
Dissertations:
(Thesis submitted to the faculty of the All India Institute of Medical Sciences, in partial fulfillment of the
requirement for the degree of Doctor in Medicine (Internal Medicine), awarded in 1988 and the degree of
Doctor in Medicine (Neurology), awarded in 1992)
1.
Seshadri S, Jain S, Pande JN, Maheshwari MC. Brain-stem auditory and visual evoked potentials
in patients with moderate to severe iron deficiency anemia.
2.
Seshadri S, Jain S, Maheshwari MC. Randomized double-blind, placebo controlled trial of
nimodipine in acute ischemic stroke.
3.
Seshadri S, Vasan RS, Ahuja GK, Shrivastava S, Reddy KS. Diastolic dysfunction in myasthenia
gravis.
Dissertations mentored:
(Thesis submitted to the faculty of the All India Institute of Medical Sciences, in partial fulfillment of the
requirement for the degree of Doctor in Medicine (Neurology), awarded 1996-98)
1. Choudhary SK, Seshadri S, Behari M, Prasad K. Hindi version of the Folstein MMSEAgreement and construct validity in educated bilingual hospitalised subjects.
2. Singh S, Seshadri S, Behari M. Effect of levodopa on cognition in patient’s with early
Parkinson’s disease-evaluation of memory and frontal lobe functions.
3. Gorthi SP, Seshadri S, , Jain S, Padma MV, Maheshwari MC. Tiagabine and cognitive function in
refractory epilepsy.
4. Nath J, Gupta S, Seshadri S, Behari M, Khandewal SK. A neuropsychological study of patients
with Alzheimer’s disease.
Abstarcts presented at national and international meetings in last 4 years:
1. Seshadri S, Wolf PA, Besier A, Au R, Wilson PWF, Selhub J, Jacques PF, Rosenberg IH,
D’Agostino RB, DeCarli C. Elevated plasma homocysteine levels are associated with subclinical
brain injury in healthy adults: relation to silent cerebral infarcts, white matter hyperintensity and
MRI brain volume in the Framingham Offspring. Neurology 2003; 60 (Suppl 1): A80.
2. Auerbach SH, Au R, Beiser A, Seshadri S, Wolf PA. Mild Cognitive Impairment: 25 year followup in the Framingham Study. Neurology 2003; 60 (Suppl 1): A244.
3. Najarian R, Seshadri S, Beiser A, Au R, Wolf PA. Blood pressure, weight loss and Alzheimer’s
disease: Insights from the Framingham Study. Neurology 2003;60 (Suppl 1): A207.
4. Seshadri S, Beiser A, Vasan RS, DeCarli C, Wang TJ, Au R, Larson MG, Levy D, Wolf PA.
Association of plasma atrial and B-type natriuretic peptides with silent cerebral infarcts and white
matter hyperintensity on brain magnetic resonance imaging. Presented at the 29th International
8
Stroke Conference, San Diego CA, Feb 2004.
5. Seshadri S, Beiser A, Kelly-Hayes M, Wolf PA. Parental occurrence of stroke and risk of stroke
in their children: The Framingham Study. Stroke 2006; 37:634.
6. Das RR, Seshadri S, Beiser AS, Himali JJ, Au R, Kelly-Hayes M, Kase CS, Benjamin EJ, Polak
JF, O’Donnell CJ, D’Agostino RB, DeCarli C, Wolf PA. Prevalence and correlates of silent
cerebral infarcts in the Framingham Offspring. Stroke 2006; 37: 672.
7. DeStefano AL, Wolf PA, Seshadri S, Nguyen A, Massaro JM, Beiser A, Au R, DeCarli CD.
Substantial Heritability of Total Brain and Temporal Lobe Volume in the Framingham Offspring
Study. [poster presentation at American Academy of Neurology meeting, 2006].
8. Romero JR, Seshadri S, Beiser AS, Au R, DeCarli C, Vasan RS, Wolf PA. Matrix
metalloproteinases are associated with MRI indices of brain ischemia and aging: The Framingham
Study. [platform presentation at American Academy of Neurology meeting, 2006].
9. Vitale S, Cabral H, DeCarli C, Seshadri S, Wolf PA, Au R. Decline in Mini-mental state
examination in subjects without dementia is associated with changes on volumetric brain MRI in
the Framingham Offspring [presented at the 34th annual meeting of the International
Neuropsychological Society, Boston, MA, February 2006].
10. Bristow KQ, Au R, Massaro JM, Seshadri S, Wolf PA, Kelly-Hayes M, DeCarli C. Relationship
of silent cerebral infarctions and white matter hyperintensities to cognitive performance: the
Framingham offspring study. [poster presentation at the Epidemiology of Alzheimer’s Disease
conference, San Diego, CA, April 2006].
11. Seshadri S, Massaro JM, Manning WJ, Au R, Beiser AS, Gona P, Petrea RE, Jefferson AL,
Benjamin ES, Vasan RS, D’Agostino RB, O’Donnell C, DeCarli C, Wolf PA. Association of Aortic
Plaque Measures with Indices of Brain Aging on Volumetric Brain MRI in the Framingham
Offspring Study [poster presentation at the International Stroke Meeting, San Francisco, Feb
2007].
12. Jefferson AL, Au R, Massaro JM, Seshadri S, Beiser AS, Benjamin EJ, Gona P, Larson MG,
O’Donnell C, Wolf PA, Manning W. Aortic plaque and neuropsychological functioning in the
Framingham Heart Study. [poster presentation at the 35th Annual meeting of the International
Neuropsychological Society, Portland, OR, February 2007.
13. Blease S, Au R, Du Y, McKee A, Devine S, Rinn W, Dennison H, O’Connor M, Beiser A,
Cabral H, Auerbach S, Seshadri S, Wolf PA, Kaplan E. Relating Clock drawing performance and
Alzheimer’s Disease pathology in the Framingham Heart Study.[poster presentation at the35th
Annual International Neuropsychological Meeting at Portland, OR, February 2007]
14. Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA. Is Declining Stroke
Incidence due to Changes in Risk Factor Prevalence or Impact? Recalibrating the Framingham
Stroke Risk Profile to Reflect Temporal Trends. [platform presentation at the International Stroke
Meeting, San Francisco, Feb 2007].
15. Palumbo C, Beiser A, DeCarli C, Au R, Seshadri S, Wolf PA. Apolipoprotein E Modifies the
Relationship of Brain MRI to Cognition: The Framingham Heart Study. [poster presentation at the
American Academy of Neurology meeting, Boston, 2007].
16. Romero JR, Polak JF, Seshadri S, Beiser A, Benjamin EJ, Vasan RS, Wolf PA. Carotid Artery
Atherosclerosis and Extracellular Matrix Remodeling: The Framingham Offspring Study.
[platform presentation at the American Academy of Neurology meeting, Boston, 2007].
17. Paul CA, Au R, Freidman L, Massaro J, Seshadri S, Wolf PA. The effect of alcohol consumption
on total brain volume: The Framingham Study. [poster presentation at the American Academy of
Neurology meeting, Boston, 2007].
18. Seshadri S, Wolf PA, Beiser A, DeCarli C, Au R, Levy D, Larson MG, Vasan RS, Benjamin EJ,
9
Mitchell GF. Arterial Stiffness and Measures of Brain Aging on Volumetric MRI and on
Cognitive Testing: The Framingham Offspring Study. [poster presentation at the American
Academy of Neurology meeting, Boston, 2007].
19. Au R, Beiser A, Seshadri S, Du Y, Cabral H, Auerbach S, DeCarli C, Wolf PA. Structural Brain
Imaging Differentiates MCI Subtypes as early as middle age: Results from the Framingham
Offspring Study. [platform presentation at the American Academy of Neurology meeting, Boston,
2007].
20. Poly CK, Au R, Jacques P, Massaro JM, Seshadri S, Wolf PA. Questionnaires in Relation to
cognitive performance in the Framingham Offspring cohort. [poster presentation at the American
Academy of Neurology meeting, Boston, 2007].
21. Albert M, Au R, Massaro JM, Seshadri S, Wolf PA, DeCarli C. Sex differences on brain MRI
and cognition in Framingham Offspring study. [poster presentation at the American Academy of
Neurology meeting, Boston, 2007].
22. Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser A, Murabito JM, Kelly-Hayes M, DeCarli
C, Atwood LD, Wolf PA. Genetic Correlates of Brain Aging on MRI and Cognitive Test
Measures: Genome Wide Association Analyses in the Framingham Heart Study. [platform
presentation at the Contemporary Clinical Issues Plenary Session at the American Academy of
Neurology meeting, Boston, 2007].
23. Petrea RE, Fears A, Feurestein J, Barest G, Seshadri S. Herpes simplex type 2 causing an atypical
encephalitis presenting as a “stroke.” (2nd prize, clinical vignettes section, Massachusetts Medical
Society Research Poster Meeting, Waltham, MA, April 2007].
24. Petrea RS, Romero JR, Seshadri S, Viereck JC, Babikian VL, Barest GD, Kase CS. Recurrent
migraines with aura as an isolated presenting symptom of cerebral venous thrombosis. [poster
presented at the European Stroke Conference, Glasgow, May 2007].
25. Tan ZS, Beiser A, Vasan RS, Au R, Kiel DP, Wolf PA, Seshadri S. Thyroid Stimulating
Hormone and the Risk of Alzheimer’s disease. [platform presentation at the American Geriatric
Society meeting, Seattle, WA, 2007].
26. Seshadri S, Beiser AS, Au R, Kelly-Hayes M, Kase CS, Wolf PA. Mild vascular cognitive
impairment predicts risk of incident stroke in the Framingham study. [poster presentation at the
VASCOG meeting, San Antonio, TX, 2007].
27. Romero JR, Beiser AS, Vasan RS, Benjamin EJ, Polak J, Wolf PA, Seshadri S. Carotid artery
atherosclerosis, MRI indices of brain ischemia and aging and cognitive impairment: The
Framingham study. [platform presentation at the VASCOG meeting, San Antonio, TX, 2007].
10
Ongoing Research Support
R01 AG16495 Wolf (PI)
NIH/NIA
12/01/98-5/31/10
MRI, Genetic and Cognitive Precursors of AD and Dementia
Role: Investigator
The goals of the study are to relate risk factors for Alzheimer’s Disease (AD) and dementia in the
Framingham Offspring and Omni cohorts to changes in brain morphology measured by Magnetic
Resonance Imaging (MR) and cognitive performance. Longitudinal data on change in MRI and
cognitive measures will enable us to further explore the hypothesis that CVRF prospectively
ascertained during mid-life play an important role in progressive brain injury leading in turn to
progressive decline in cognition, increasing the likelihood of mild cognitive impairment (MCI) or
dementia in later life. Finally, we will combine extensive genetic information in younger individuals
with a documented family history of dementia to explore potential early changes in brain structure and
cognition that may be under genetic influence.
R01 AG08122 Wolf (PI)
NIH/NIA
01/01/89-05/31/10
Epidemiology of Dementia in the Framingham Study
Role: Investigator
The goals of the study are to expand cognitive surveillance efforts to the older FHS Offspring and
multi-ethnic OMNI cohorts permitting us to explore the familial occurrence of AD and dementia and
to relate mid-life habits and risk factors to incidence of AD and other types of dementia. More than
420 of these Offspring and OMNI subjects have volunteered as brain donors, and we plan to relate
vascular pathology in the brain at autopsy to mid-life vascular risk factors measured over several
decades. This study will permit us to address a key question of whether vascular risk factors, especially
those present at midlife, increase the risk of clinical and pathological dementia generally, and AD
specifically.
R01 NS17950 Wolf (PI)
NIH/NINDS
12/01/81-06/30/09
Precursors of Stroke Incidence and Prognosis
Role: Investigator
The study will further the understanding of the epidemiology of stroke through identification of newer
risk factors and genetic influences. Clinical and subclinical strokes will be studied utilizing the rich
multi-generational family-based structure. Clinical and subclinical strokes will be related to
documented clinical stroke in parents and siblings to assess the impact of stroke risk factors depending
on family history of stroke.
Pending Support
R01 (PI: Jacob Selhub)
NIH/NIA
07/01/08-06/30/10
Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring Study
Role: PI of Framingham Subcontract
R01 (PI: Myriam Fornage)
NIH/NHLBI
07/01/08-06/30/12
A genome-wide association study of ischemic brain vascular injury in ARIC
Role: PI of Framingham Subcontract
R01 (PI: Seshadri)
NIH/NIA
07/01/08-06/30/12
Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
Role: Principal Investigator
11