The Paul F. Glenn/AFAR Conference on the Biology of Aging The 28th Annual AFAR Grantee Conference June 1 – 3, 2015 Four Seasons Biltmore Hotel Santa Barbara, CA DRAFT – May 13, 2015 Monday, June 1, 2015 3:30 p.m. - 4:00 p.m. Alto Registration/reception 4:00 p.m. – 4:15 p.m. El Mar Welcome Stephanie Lederman Executive Director American Federation for Aging Research Harvey Jay Cohen, M.D. President, American Federation for Aging Research and Walter Kempner Professor of Medicine Director, Center for the Study of Aging Duke University Medical Center 4:15 p.m. – 5:00 p.m. "Chromatin folding, age dependent memory decline and age induced haploinsufficiency." Giovanni Bosco, Ph.D. (2013 BIG recipient) Associate Professor, Geisel School of Medicine at Dartmouth 5:00 p.m. – 5:45 p.m. “Rapamycin: The first longevity drug?” Arlan Richardson, Ph.D. Donald W Reynolds Endowed Chair of Aging Research Professor of Geriatric Medicine University of Oklahoma Health Science Center 5:45 p.m. – 6:00 p.m. break Monday, June 1, 2015 (continued) 6:00 p.m. – 7:00 p.m. Felipe Sierra, Ph.D. Director of the Division of Aging Biology National Institute on Aging, NIH 7:00 p.m. – 8:30 p.m. El Mar Dinner 8:30 p.m. – 9:30 p.m. Alto Social gathering, with dessert, coffee and wine Tuesday, June 2, 2015 Glenn Workshop and AFAR Grantee Conference Joint meeting The Glenn Medical Foundation – 50th Anniversary Fifty years of aging research: What have we learned, where do we go from here? Moderator: Kevin Lee 7:30 – 8:30 a.m. La Marina Breakfast 8:30 – 8:45 a.m. La Veranda Welcome and opening remarks Mark Collins President, Glenn Foundation for Medical Research 8:45 – 9:00 a.m. Meeting overview and goals Kevin Lee, Ph.D. Senior Scientific & Programmatic Advisor, Glenn Foundation for Medical Research 9:00 – 10:30 a.m. Session One: Fifty Years of Aging Research: Past, Present, Future Moderator: Edward Lakatta, M.D., NIA Speakers: Steven Austad, Ph.D., UAB George Martin, M.D., University of Washington Session will provide a backdrop, discussing major areas of inquiry over the past fifty years, lessons learned, which areas are still being investigated, emerging and promising areas, how is technology shaping research. 10:30 – 11:00 a.m. Break Tuesday, June 2, 2015 (continued) 11:00 a.m. – 12:30 p.m. Session Two: How to Optimize your Message Moderator: Erika Check Hayden, reporter for Nature Panelists: Richard Faragher, M.D., University of Brighton James Kirkland, M.D., Ph.D., Mayo Clinic Christopher Scott, Ph.D., Stanford University Credibility of our messages hinges on the quality of scientific explanations. Findings that emerge from the aging research field are often extrapolated by the media and/or repackaged into messages promising fountains of youth. Terms such as “anti-aging, immortality, ending aging” harm the field more than they do good. This session will discuss how we can best communicate our messages - can the aging community agree on common language? 12:30 – 1:30 p.m. Palmera Garden Lunch 1:30 – 3:00 p.m. Session Three: Resistance to Aging - Optimizing damage response pathways Moderator: Kevin Lee, Ph.D., Glenn Foundation for Medical Research Speakers: Judith Campisi, Ph.D., Buck Institute for Research on Aging Susan Lindquist, Ph.D., Whitehead Institute for Biomedical Research, and MIT Gary Ruvkun, Ph.D., Harvard University Pathways that identify damaged molecules, organelles, and tissues and repair this damage underlie the ability to resist the effects of aging and maintain healthy function. At the same time, dysregulated or chronically activated repair pathways contribute to aging-associated pathogenesis. This session will provide an overview of our current understanding of surveillance and stress response pathways, and consider how these pathways can be optimized to strike a balance between beneficial and detrimental responses to stress and toxic insults. 3:00 – 5:30 p.m. Loggia Ballroom AFAR Grantee Poster Session 6:00 – 7:00 p.m. La Pacifica Terrace Reception 7:00 – 9:00p.m. La Pacifica Dinner Speaker: Stuart Firestein, Ph.D., Columbia University Kindly remove your poster at the conclusion of the session. Wednesday, June 3, 2015 7:30 a.m. – 9:00 a.m. La Marina Breakfast Adjourn Grantees with a twitter account are encouraged to tweet at least once during the conference using the #Iamascientistbecause tag + @AFARorg 2014 Major Sponsors of AFAR Grant Programs The AFAR Board of Directors Anonymous AFAR 2014 Regional Dinner Funds The Lawrence Ellison Foundation The Glenn Foundation for Medical Research The Rosalinde and Arthur Gilbert Foundation David W. Gore Diana Jacobs Kalman F.M. Kirby Foundation, Inc. Diane Nixon Pfizer Inc The Irving S. Wright Endowment