Kyriakos Anastasiadis, MD, PhD, FETCS, FCCP, FESC Assoc. Professor of Cardiothoracic Surgery, Aristotle University of Thessaloniki Head – Director of Cardiothoracic Dept, AHEPA University Hospital, Thessaloniki, Greece Secretary General of the Hellenic Society of Thoracic and Cardiovascular Surgeons Date of birth: 19/09/1967 Place of birth: Xanthi, Greece Nationality: Greek Marital status: married (2 children) Address: AHEPA Hospital, S. Kyriakidi 1, 54636, Thessaloniki, Greece. tel. +30 2310994845, +30 6976704774, fax: +30 2310994871 e-mail: anastasi@med.auth.gr, anastasiadisk@hotmail.com Degrees: - Ptychion Iatrikes (MD), 1991 - Greek Boards of Cardiothoracic Surgery, 2000 - UK GMC (General Medical Council) Specialist Register, 2001 - Medical Thesis (PhD) - Aristotle University of Thessaloniki, 2004 - UEMS - European Boards of Thoracic and Cardiovascular Surgery (FETCS), 2005 - Ass. Professor of Cardiothoracic Surgery - Aristotle University of Thessaloniki, 2007 - Fellow - European Society of Cardiology (FESC), 2011 - Fellow - American College of Chest Physicians (FCCP), 2011 - Director – Head of the Dept. of Cardiothoracic Surgery, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, 2011 - Assoc. Professor of Cardiothoracic Surgery - Aristotle University of Thessaloniki, 2012 Residency: - 1991-1994: General Surgery, General State Hospital, Kavala, Greece - 1995-1996: Orthopedics - 424 Military Hospital, Thessaloniki, Greece - 1996-2000: Cardiothoracic Surgery, AHEPA University Hospital, Thessaloniki, Greece Fellowship: - 2000-2002: Senior Registrar, Oxford Heart Centre, John Radcliffe Hospital, Oxford, UK Special training: Minimal extracorporeal circulation (MECC systems) - 2007: Klinik fur Herz-Thorx und herznahe, Regensburg, Germany - 2008: Antonius Hospital, Nieuwgein, Netherlands Heart failure surgery (LVAD, ECMO, heart transplantation) - 2002: Transplant Unit, Cardiothoracic department, Harefield Hospital, Middlesex, UK - 2004: Klinik fur Thorx und Kardiovaskularchirurgie, Bad Oyenhausen, Germany - 2009: Klinik fur Thorx und Kardiovaskularchirurgie, Bad Oyenhausen, Germany - 2009: Deutsches Herzzentrum Berlin, Germany - 2011: Klinik für Herz-Thoraxchirurgie, AKH Vienna, Austria 1 Clinical Practice: Chief Cardiothoracic Surgeon, Cardiothoracic Department, AHEPA University Hospital, Thessaloniki, Greece Main clinical practice and research: - Minimal Extracorporeal Circulation (Tutor: International & National Referral and Teaching Centre on MECC systems) - Heart failure surgery (stem cells, mechanical support: ECMO, LVAD) - Valve repairs - Thymic surgery Member of Scientific Societies: - Hellenic Society of Thoracic and Cardiovascular Surgery - Secretary General - European Society of Cardiology - Hellenic Cardiological Society - European Association for Cardiothoracic Surgery - Society for Thoracic Surgery – USA - American College of Chest Physicians – USA - Euromacs (European Registry for Patients with Mechanical Circulatory Support) Invited Lectures: - 82 lectures in International and National Scientific Congresses, best: invited lecture in the «Medical Innovations Summit» of the Royal Society of Medicine, UK: World's First Artificial Heart and Stem Cell Operation, 2010 - 32 Chairs in International and National Scientific Sessions Committees: - Member of the «Working Group on Cardiovascular Surgery» of the European Society of Cardiology - Member of the Euromacs – European Registry of Patients with Mechanical Circulatory Support - Member of the Committee for the European Educational Programmes (ECTS) of the Senate of Aristotle University of Thessaloniki - President of the Committee for the Education of the Hellenic Society of Thoracic and Cardiovascular Surgeons - President of the Nucleus «Education and Ethics Working Group» of the Hellenic Society of Thoracic and Cardiovascular Surgeons - Former Secretary of the Nucleus «Heart Failure Working Group» of the Hellenic Society of Thoracic and Cardiovascular Surgeons - Member of the National (Greek) Boards of Cardiothoracic Surgery Congresses: - President of 1st International Symposium of Minimal Invasive ExtraCorporeal Technologies, 2014 - Secretary of 7th Symposium of the Hellenic Society of Thoracic and Cardiovascular Surgery, 2013 2 - Secretary of 6th Symposium of the Hellenic Society of Thoracic and Cardiovascular Surgery, 2012 - Secretary of 5th Symposium of the Hellenic Society of Thoracic and Cardiovascular Surgery, 2011 - Member of the Organising Committee and Tutor of the Video-Assisted Thoracoscopic Surgery Course of the European Association for CardioThoracic Surgery, 2010 - Member of the Scientific Committee of the 3rd Interventional Cardiology Congress of Northern Greece, 2010 - Member of the Organising Committee of the 8th Congress of the Hellenic Society of Thoracic and Cardiovascular Surgery, 2010 - Secretary of 4th Symposium of the Hellenic Society of Thoracic and Cardiovascular Surgery, 2009 - Member of the Scientific Committee of the 8th Northern Greece Cardiology Congress, 2009 - Secretary of 7th Congress of the Hellenic Society of Thoracic and Cardiovascular Surgery, 2008 - Member of the Organising Committee of the 18th World Society of CardioThoracic Surgeons, 2008 - Member of the Scientific Committee of the 6th Congress of the Hellenic Society of Thoracic and Cardiovascular Surgery, 2006 - Member of the Organising Committee of the 2nd International Congress of Aerospace Medicine, 2004 - Member of the Organising and Scientific Committee of the 2nd Ιnternational Symposium of Aerospace Medicine, 2004 Major contributions to launching the careers of researchers - 23 PhD students for various research projects in cardiothoracic surgery. - 2 Masters Degree students for various research projects. Recognised leadership in industrial innovation - Scientific Consultant for PulseCath BV, Orlyplein 85, 1043 DS, Amsterdam, The Netherlands: mechanical assist devices for the heart prototypes projects. Awards: - Best Innovator: 8th EuroAsian Bridge Congress, Mashhad, Iran 2011, for the research on «stem cells and mechanical support as treatment for the end stage ischemic heart failure; the hybrid approach». - K. Anastasiadis, P. Antonitsis, C. Vaitsopoulou, Α. Doumas, H. Argiriadou, V. Grosomanidis, G. Koliakos, C. Foroulis, C. Papakonstantinou. Hybrid treatment of end-stage ischemic heart failure with implantation of ventricular assist device and autologous bone marrow stem cells: preliminary results. 8th National Congress of Cardiothoracic Surgery, Athens, November 2010. - K. Megari, M. Kosmidis, E. Aretouli, E. Thomaidou, H. Argiriadou, C. Papakonstantinou, K. Anastasiadis. Impact of two different extracorporeal circulation systems to the postoperative cognitive dysfunction after cardiac surgery. Heart & Mind, Tuscany, Italy, September 2010. - K. Anastasiadis, P. Antonitsis, G. Karapanagiotidis, H. Argiriadou, C. Foroulis, C. Papakonstantinou. Salvage of patient with left ventricular free wall rupture using ECMO system. 7th National Congress of Cardiothoracic Surgery, Thessaloniki, November 2008. - H. Argiriadou, K. Anastasiadis, E. Aretouli, G. Karapanagiotidis, P. Antonitsis, E. Thomaidou, V. Grosomanidis, C. Foroulis, Μ. Kosmides, C. Papakonstantinou. Effect of minimal versus conventional extracorporeal circulation in cognitive function of patients undergoing coronary artery bypass surgery: a pilot study. 23rd Northern Greece Medical Congress, Thessaloniki, March 2008. 3 List of most significant publications Assoc. Prof. Kyriakos Anastasiadis is the Editor of three books and has published over 50 scientific papers in peer-reviewed journals with more than 400 citations. Books: - K. Anastasiadis, C. Ratnatunga. The Thymus Gland: Diagnosis and Surgical Management, Springer, Germany, 2007. - K. Anastasiadis, P. Antonitsis, H. Argiriadou. Principles of Miniaturized ExtraCorporeal Circulation, Springer, Germany, 2013. - K. Anastasiadis, S. Westaby, P. Antonitsis. The Failing Right Heart, Springer, Germany (under publication). Chapter: - K. Anastasiadis, R. Pillai. Myocardial preservation: non-cardioplegic techniques. In «A. Tang, S.K. Ohri, L.W. Stephenson: Key topics in cardiac surgery», Taylor and Francis Eds, UK, 2004. Published work on the field of Extracorporeal Circulation Technologies: - Bauer A, Schaarschmidt J, Anastasiadis K, Carrel T. Reduced amount of gaseous microemboli in the arterial line of minimized extracorporeal circulation systems compared with conventional extracorporeal circulation. Eur J Cardiothorac Surg. 2013 Sep 18. - Anastasiadis K, Fragoulakis V, Antonitsis P, Maniadakis N. Coronary artery bypass grafting with minimal versus conventional extracorporeal circulation; an economic analysis. Int J Cardiol. 2013 Oct 15;168(6):5336-43. - Anastasiadis K, Asteriou C, Antonitsis P, et al. Enhanced recovery after elective coronary revascularization surgery with minimal versus conventional extracorporeal circulation: a prospective randomized study. J Cardiothorac Vasc Anesth. 2013 Oct;27(5):859-64. - Asteriou C, Antonitsis P, Argiriadou H, Deliopoulos A, Konstantinou D, Foroulis C, Papakonstantinou C, Anastasiadis K. Minimal extracorporeal circulation reduces the incidence of postoperative major adverse events after elective coronary artery bypass grafting in high-risk patients. A single-institutional prospective randomized study. Perfusion. 2013 Jul;28(4):350-6. - Anastasiadis K, Hadjimiltiades S, Antonitsis P. Successful high-risk percutaneous coronary intervention with the use of minimal extracorporeal circulation system. Catheter Cardiovasc Interv 2012;80:845-849. - Anastasiadis K, Antonitsis P, Haidich AB, et al.Use of minimal extracorporeal circulation improves outcome after heart surgery; a systematic review and meta-analysis of randomized controlled trials.Int J Cardiol. 2012 Feb 8. [Epub ahead of print] - P. Antonitsis, K. Anastasiadis, H. Argiriadou, et al. Improved neurocognitive outcome after coronary artery bypass surgery using minimal versus conventional extracorporeal circulation: a randomized controlled study. J Am Coll Cardiol 2011;57(Suppl A):E910. - K. Anastasiadis, H. Argiriadou, M.H. Kosmidis, et al. Neurocognitive outcome after coronary artery bypass surgery using minimal versus conventional extracorporeal circulation: a randomised controlled pilot study. Heart 2011 Feb 28. [Epub ahead of print] 4 - K. Anastasiadis, O. Chalvatzoulis, P. Antonitsis, et al. Use of minimized extracorporeal circulation system in noncoronary and valve cardiac surgical procedures – a case series. Artif Organs 2011;35:960-963 - K. Anastasiadis, A. Antonitsis, C. Papakonstantinou. When is the optimal timing to perform neurocognitive assessment after coronary artery bypass surgery? Ann Thorac Surg 2011;92:1933. - K. Anastasiadis, P. Antonitsis, H. Argiriadou, et al. Use of minimal extracorporeal circulation circuit for left ventricular assist device implantation. ΑSAIO J 2011;57:547-549. - K. Anastasiadis, S. Westaby, P. Antonitsis, et al. Papakonstantinou. Minimal extracorporeal circulation circuit standby for “off-pump” left ventricular assist device implantation. Artif Organs 2010;34:1156-1158. - K. Anastasiadis, C. Asteriou, A. Deliopoulos, et al. Hematologic effects of minimized compared to conventional extracorporeal circulation after coronary revascularization procedures. Perfusion 2010;25:197-203. - E. Thomaidou, K. Megari, E. Argiriadou, K. Anastasiadis, M. Kosmidou. Intraoperative cerebral desaturation as prognostic factor for the neurocognitive outcome and the prolonged hospitalization after coronary artery bypass grafting surgery. Intensive Care Medicine 2010;36(Suppl 2):S328. - Anastasiadis K, Antonitsis P, Hadjimiltiades S, et al. Management of left ventricular free wall rupture under extracorporeal membrane oxygenation support. Int J Artif Organs. 2009 Oct;32(10):756-8. Other scientific papers: - S. Westaby, S. Saito, K. Anastasiadis, N. Moorjani, X.Y. Jin. Aortic root remodeling in atheromatous aneurysms: The role of selected sinus repair. Eur J Cardiothorac Surg 2002;21:459-464. - K. Anastasiadis, K.H. Channon, C. Ratnatunga. Traumatic innominate artery transection. J Cardiovasc Surg 2002;43:697-700. - D.P. Taggart, B. Choudhary, K. Anastasiadis, et al. Preliminary experience with a novel intraoperative fluorescence imaging technique to evaluate the patency of bypass grafts in total arterial revascularization. Ann Thorac Surg 2003;75:870-873. - Y. Abu-Omar, S. Mussa, K. Anastasiadis, et al. Duplex ultrasonography predicts safety of radial artery harvest in the presence of an abnormal Allen test. Ann Thorac Surg 2004;77:116-119. - L. Balacumaraswami, Y. Abu-Omar, K. Anastasiadis, et al. Taggart. Does off-pump total arterial grafting increase the incidence of intraoperative graft failure? J Thorac Cardiovasc Surg 2004;128:238244. - H. Kattach, K. Anastasiadis, X.Y. Jin, R. Pillai. Two-conduit repair for anomalous origin of the left coronary artery from the pulmonary artery in an adult. J Thorac Cardiovasc Surg 2004;128:641-642. - H. Kattach, K. Anastasiadis, J. Cleuziou, et al. Transsternal thymectomy for myasthenia gravis: surgical outcome. Ann Thorac Surg 2006;81:305-308. - K. Anastasiadis, G. Moschos. Diabetes mellitus and coronary revascularization procedures. Int J Cardiol 2007;119:10-14. - K. Anastasiadis, T.D. Karamitsos, I. Velissaris, et al. Preoperative screening and management of carotid artery disease in patients undergoing cardiac surgery. Perfusion 2009;24:257-262. - K. Anastasiadis, P. Antonitsis, S. Hadjimiltiades, et al. Management of left ventricular free wall rupture under extracorporeal membrane oxygenation support. Int J Artif Organs 2009;32:756-758. 5 - G.T. Karapanagiotidis, P. Antonitsis, N. Charokopos, C.N. Foroulis, K. Anastasiadis, et al. Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia. J Cardiothorac Surg 2009;4:59-65. - K. Anastasiadis, P. Antonitsis, C. Papakonstantinou, S. Westaby. Use of Jarvik 2000 left ventricular assist device for treating acutely decompensated heart failure. Eur J Cardiothorac Surg 2009;35:172. - I. Velissaris, D. Kiskinis, K. Anastasiadis. One stage carotid artery stenting and open heart surgery: a novel approach. J Cardiovasc Surg 2009 May 19. [Epub ahead of print]. - H. Argiriadou, K. Anastasiadis, P. Antonitsis, et al. The inability of regional oxygen saturation monitoring in a patient with alkaptonuria undergoing aortic valve replacement. J Cardiothorac Vasc Anesth 2009;23:586-588. - H. Argiriadou, K. Anastasiadis, P. Antonitsis, et al. Use of cerebral oximetry for monitoring cardiac output during off-pump implantation of Jarvik 2000 left ventricular assist device. Artif Organs 2010;34:267-269. - H. Argiriadou, K. Megari, P. Antonitsis, M.H. Kosmidis, C. Papakonstantinou, K. Anastasiadis. Nonpulsatile circulation with axial-flow left ventricular assist device preserves neurocognitive function. Perfusion 2010;25:225-228. - K. Anastasiadis, D. Koulaksis, I. Velissaris. Endovascular repair of an internal mammary artery to pulmonary artery acquired fistula. J Card Surg 2010;25:666-668. - H. Argiriadou, K. Anastasiadis, G. Karapanagiotidis, C. Papakonstantinou. Subclinical decline in cerebral oxymetry saturation during rapid pacing in transfemoral aortic valve replacement. Ann Thorac Surg 2010;90:1023. - H. Argiriadou, P. Papagiannopoulou, C.N. Foroulis, K. Anastasiadis, et al. Intraoperative infusion of S(+)-Ketamine enhances post-thoracotomy pain control compared with perioperative parecoxib when used in conjunction with thoracic paravertebral ropivacaine infusion. J Cardiothorac Vasc Anesth 2011;25:455-461. - K.C. Koskinas, Y.S. Chatzizisis, V. Kamperidis, K. Anastasiadis, et al. Extremely rare case of primary cardiac chondroma in a patient presenting with acute pulmonary edema. Cardiovasc Pathol 2011;20:374-376. - K. Anastasiadis, H. Argiriadou, P. Antonitsis, et al. Cerebral oximetry-guided antegrade cerebral perfusion in aortic arch surgery. J Cardiothorac Vasc Anesth 2011;25:591-592. - K. Anastasiadis, H. Argiriadou, P. Antonitsis, et al. Use of rapid ventricular pacing for facilitating left ventricular assist device implantation. J Cardiothorac Vasc Anesth 2011 Jun;25(3):598-600. - K. Anastasiadis, P. Antonitsis, H. Argiriadou, et al. Hybrid approach of ventricular assist device and autologous bone marrow stem cells implantation in end-stage ischemic heart failure enhances myocardial reperfusion. J Transl Med 2011;9:12. - I. Velissaris, D. Kiskinis, K. Anastasiadis. Synchronous carotid artery stenting and open heart surgery. J Vasc Surg 2011;53:1237-1241. - H. Argiriadou, K. Anastasiadis, E. Thomaidou, D. Vasilakos. Reversal of neuromuscular blockade with sugammadex in an obese myasthenic patient undergoing thymectomy. J Anesth 2011;25:316-317. - K. Anastasiadis, P. Antonitsis, O. Chalvatzoulis, C. Papakonstantinou. Use of a novel short-term mechanical circulatory support device for cardiac recovery. J Heart Lung Transplant 2011;30:732-733. - K. Anastasiadis, O. Chalvatzoulis, P. Antonitsis, et al. Use of minimized extracorporeal circulation system in noncoronary and valve cardiac surgical procedures – a case series. Artif Organs 2011;35:960-963. 6 - C.N. Foroulis, K. Anastasiadis, N. Charokopos, et al. A modified two-port thoracoscopic technique versus axillary minithoracotomy for the treatment of recurrent spontaneous pneumothorax; a prospective randomized study. Surg Endosc 2012;26:607-614. - P. Antonitsis, K. Anastasiadis, O. Chalvatzoulis, et al. Factors associated with the development of acute heart failure in critically-ill patients with severe pandemic 2009 influenza A (H1N1) infection. Ann Thorac Surg 2011;91:2021-2022. - K. Anastasiadis, O. Chalvatzoulis, P. Antonitsis, P. Tossios. Left ventricular decompression during peripheral extracorporeal membrane oxygenation support with the use of the novel iVAC pulsatile paracorporeal assist device. Ann Thorac Surg 2011;92:2257-2259 - K. Anastasiadis, P. Antonitsis, A. Doumas, G. Koliakos, H. Argiriadou, C. Vaitsopoulou, P. Tossios, C. Papakonstantinou, S. Westaby. Stem cells transplantation combined with long-term mechanical circulatory support increases myocardial viability in end-stage ischemic cardiomyopathy. Int J Cardiol 2012;155:e51-53. - S. Westaby, K. Anastasiadis, G. Wiesenthaler. Cardiogenic shock in ACS. Part 2: Role of mechanical circulatory support. Nat Rev Cardiol 2012;9:195-208. 7