CURRICULUM VITAE
Prof. Dr. Songqin Liu
School of Chemistry and Chemical Engineering
Southeast University
Jiangning, Nanjing, 211189
E-mail: liusq@seu.edu.cn
Tel.: +86-52090613
D.O.B.: March 19, 1965
P.O.B.: Jiangsu, P. R. China
Position
2002-present
Postdoctoral researcher
2005,9-present
University
Professor of Chemistry in Southeast
Vice dean of School of Chemistry and Chemical Engineering
Research chair of Bioanalytical Chemistry in SEU
Research interest
1) Nanobiosensing: Nanobioprobe could be used in the detection of biomolecules and
the study of physiologically cellular pharmacology and cellular signal transitional
mechanism. These could be realized by the synthesis and functionalization of
photoelectrical nanomaterials, which are provided with molecular recognition and
signal output. Synthesis and functionalization of nanostructured materials for
biosensing. These nanostructured materials include N-doped carbon
nanotubes/nanospheres,
quantum
dots,
nanobioprobes
based
on
enzyme/QDs/Ru(bpy)32+
with
electrochemical,
chemiluminescence
and
electrochemiluminescence detection.
2) Drug metabolism with cytochrome P450. In this area, we hope to develop an
improved system to study the two-electron delivery reaction pathway of cytochrome
P450 in vitro. The direct electrochemistry and electrocatalytic behaviors of
cytochrome P450 toward common drugs in the absence of NADHP–cytochrome
P450 reductase as electron donor were studied. This confirmed that the same
pathways for cytochrome P450-mediated drug metabolism, similar to what occurred
in vivo.
3) Basic behavior of biomolecules in confined nanospaces: The occurrence and
development of life activities are based on the complex biochemical reactions
between the functional biomolecules. For example, the biological functions and the
metabolic efficiency in living systems are dominated by the multienzyme complexes
in organism (i.e. metabolon). For the nano-sized biomolecules could play extremely
important physiological functions in the confined micro-/nanospaces. Our researches
are focused on the basic behavior of biomolecules in confined nanospaces, which is
based on the construction of biomolecule/nanomaterial assembly (such as nanotube
and nanocage). Such simulated metabolon in vitro is crucially important in the
evaluation of life activities and the synergism of multi-enzymatic cascade
metabolism.
4) Polymerization-assisted
signal
amplification
of
biodetection:
Polymerization-assisted signal amplification is based on the reactive radical
polymerization and the polymerization growth of signal markers. Such signal
amplification is essentially different from traditional methods, which provides a
sensitive and rapid method for biomolecule detection.
5) Biological methane into methanol: Methane is the main component of natural gas,
which is mainly used as energy gas. Methane could be biologically transformed into
methanol by methane monooxygenase, which has high selectivity and yield. Our
researches are focused on the realization of biological methane into methanol by the
electrode or sunlight instead of the coenzymes in living systems.
Selected Publications
1.
Yafeng
Wu,
Songqin
Liu*,
Lin
He*,
Electrochemical
Biosensing
Using
Amplification-by-Polymerization. Anal. Chem. 81, 7015-7021 (2009)
2. Jing Qian, Chunyan Zhang, Xiaodong Cao, Songqin Liu*, Versatile Immunosensor Using
Quantum Dot Coated Silica Nanosphere as Label for Signal Amplification. Anal. Chem. 82,
6422–6429 (2010)
3. Yafeng Wu, Chengliang Chen, Songqin Liu*, Enzyme-functionalized silica nanoparticles as
sensitive labels in biosensin, Anal. Chem. 81, 1600-1607 (2009)
4. Xuan Xu, Shujuan Jiang, Zheng Hu, Songqin Liu*, Nitrogen-Doped Carbon Nanotubes: High
Electrocatalytic Activity toward the Oxidation of Hydrogen Peroxide and Its Application for
Biosensing. ACS Nano 4, 4292-4298 (2010)
5. Liyuan Chen, Chengliang Chen, Ruina Li, Ying Li, Songqin Liu*, CdTe Quantum Dots
Functionalized Silica Nanospheres As Labels for Ultrasensitive Detection of Biomarker.
Chem. Commun. 2670–2672 (2009)
6. Liang Yuan, Yafeng Wu, Hongyan Shi, Songqin Liu*, Surface-Initiated Atom Transfer Radical
Polymerization of 4-Acetoxystyrene for Immunosensing. Chem. Eur. J. 17, 976-983 (2011)
7. Yafeng Wu, Hongyan Shi, Liang Yuan, Songqin Liu*, A novel electrochemiluminescence
immunosensor
via
polymerization-assisted
amplification.
Chem.
Commun.
46,
7763-7765(2010)
8. Songqin Liu, Kewei Wang, Dan Du, Yueming Sun, Lin He, Recognition of glycoprotein
peroxidase via Con A-carrying self-assembly layer on gold, Biomacromolecules 8, 2142-2148
(2007)
9. Songqin Liu, Baoping Lin, Xiaodi Yang, Qianqian Zhang, Carbon-Nanotube- Enhanced Direct
Electron-Transfer Reactivity of Hemoglobin Immobilized on Polyurethane Elastomer Film, J.
Phys. Chem. B, 111, 1182-1188(2007)
10. Yafeng Wu, Wei Wei, Songqin Liu*, Target-triggered polymerization for biosensing. Acc.
Chem. Res. 45(9), 1441–1450 (2012)