Title
Analytical Methodology
Code
CH205
Level
5
Credit rating
10 points
Prerequisites
none, but CH101 or CH114 recommended
Type
Compulsory for Biomedical Sciences
Optional for MSS Chemistry Field
Aims
Learning outcomes
•
To introduce students to Analytical Science
•
To enable students to describe the principles of analytical and
separation science.
•
To enable students to have an understanding of the general
approach to an analytical problem.
•
To enable students to gain laboratory experience of a selection
of analytical problems.
At the end of this module, students should be able to:
•
Argue the relative merits of methods of analysis available for a
problem
•
Discuss the problems of obtaining a representative sample
•
Understand the principles of separation science
•
To understand the basic principles of analytical spectrometry
•
Explain alternative methods of formulating samples for
quantitative analysis
•
Evaluate the results of an analytical experiment in terms of
accuracy and precision
•
Have an appreciation of the main modern analytical methods
available, their applications and limitations
•
Apply appropriate statistical tests to analytical data.
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Content
• The role and significance of analytical chemistry in science and
society, ‘fitness for purpose’ of analytical data.
Teaching and
Learning Strategy
•
The analytical process, classification of quantitative methods of
analysis, steps in a typical quantitative analysis.
•
The preparation and storage of analytical samples.
•
Classical methods of analysis: gravimetric and titrimetric
analysis, comparison with instrumental methods.
•
Evaluation of analytical data: Student’s t-test, F-test, Dixon’s
Q, detection limits, errors and uncertainty, inter laboratory
errors.
•
Separation methods: survey, solvent extraction, use in clean up
and/or pre-concentration of analytes.
•
Principles of chromatography with examples of HPLC, GLC,
and tlc, optimisation of column performance, band shapes and
band broadening,
•
Spectrometry: emission, absorption, fluorescence, line and
band spectra, Beer’s law, calibration methods, basic
instrumentation, applications.
•
Workshops on exercises in data manipulation and statistical
significance testing in analytical science
•
Indicative practical work:
mini-project comparing alternative analytical methods
27 hours lectures, 6 hours labs, 6 hours workshops, 61 hours
private study
Learning Support
Texts
Skoog,D. A., West, D. M. and Holler, F. J., Fundamentals of
Analytical Chemistry, Holt-Saunders, 7th edn., 1996.
Harris, D. C., Quantitative Chemical Analysis , WH Freeman, 5th
edn., 1998.
R.Kellner, J-M.Mermet, M.Otto and H.M.Widmer (Eds).
Analytical Chemistry, Wiley-VCH, Chichester, 1998
J.C.Miller and J.N.Miller Statistics and Chemometrics for
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Analytical Chemistry, 4th Edition, Ellis Horwood, Chichester,
2000
Tyson, J., Analysis:What Analytical Chemists Do, Royal Society
of Chemistry, 1994.
Beckett, A.H. and Stenlake, J.B., Practical Pharmaceutical
Chemistry, Vol 1, Athlone Press, 4th edn., 1987
Beckett, A.H. and Stenlake, J.B., Practical Pharmaceutical
Chemistry, Vol 2, Athlone Press, 4th edn., 1988
CAL packages
Pharmaceutical Analysis Titrimetry , Jee, R., PCCAL,V 2.0,1995.
Introduction to Spectroscopy, Cartwright, H., Sudlow, K. , Potter.,
G, Bell, M., O’Malley, R. and Walmsley, T., C-Cubed, V1.0, 1995.
Videos
Basic Laboratory Skills, Laboratory of the Government Chemist,
1995.
Further Laboratory Skills, Laboratory of the Government Chemist,
1996.
Assessment
An element of continuous assessment will be applied to laboratory
reports. There will in addition be an end-of-module examination.
Programme of continuous assessment
End of module examination
50%
50%
Brief description
of the module
The module provides an introduction to analytical science. The
student gains an appreciation of: sampling; sample preparation;
separation science (including a more detailed coverage of
chromatography); spectrometry and the criteria for choosing an
analytical method. Emphasis is placed on the evaluation of
chemical data by means of statistical tests.
Area Examination
Board
Chemistry
Module Team
Dr A Willows
Semester offered
1
Timetable slot
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Site where delivered
Moulsecoomb
Date of first approval
1992
Date of last revision
2001
Version number
3
Replacement for
previous module
Field for which
module is acceptable
Status in that Field
Course(s) for which
module is acceptable
Chemistry
(1) BSc Hons Biomedical Sciences
(2) MSS BSc Hons Joint Sciences Chemistry Field
(2) BSc Hons Environmental Sciences
Status in course
(1) Compulsory; (2) Optional
Departmental home
School of Pharmacy and Biomolecular Sciences
External Examiner
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