醫學
院
生技
系、所
師資陣容
姓名
沈家瑞
實驗室分機
實驗室位置
5200
第一醫學大樓 1166
English Name
職稱
Chia-Rui Shen
副教授
Title
畢業學校
Associate Professor
（一）國立成功大學
（二）英國布里斯托大學
School
學位
（一）National Cheng Kung University
（二）University of Bristol, UK
（一）理學士
（二）博士
Degree
畢業年次
（一）BSc
（二）Ph.D.
（一）1993
（二）1998
Year of graduation
（一）1993
（二）1998
研究領域
Research Topic
免疫疾病與癌症之免疫療法、檢驗試劑研發及分子影像應用
Development of immunotherapeutics, diagnostics and magnetic resonance
contrast agents
1. Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, Chou AH,
Chang SR, Hsiao KN, Yu FW, Chen HW. Induction of a distinct CD8
Tnc17 subset by transforming growth factor-beta and interleukin-6. J
Leukoc Biol 2007 Aug; 82(2): 354- 360. Epub 2007 May 15.
SCI=4.605 (19.01%)
近五年發表
2.
Hall AM, Ward FJ, Shen CR (equal to first), Rowe C, Bowie L,
Devine A, Urbaniak SJ, Elson CJ, Barker RN. Deletion of the
dominant autoantigen in NZB mice with autoimmune hemolytic
anemia: effects on autoantibody and T-helper responses. Blood 2007
Dec 15; 110(13): 4511- 4517. Epub 2007 Sep 4. SCI=10.555 (3.28%)
3.
Chiu CC, Lin CY, Lee LY, Chen YJ, Kuo TF, Chang JT, Liao CT,
Wang HM, Yen TC, Shen CR, Liao SK, Cheng AJ.
Glucose-regulated protein 78 regulates multiple malignant
phenotypes in head and neck cancer and may serve as a molecular
target of therapeutic intervention. Mol Cancer Ther 2008 Sep; 7(9):
2788-2797. SCI=4.953 (16.36%)
4.
Susanto J, Lin YH, Chen YN, Shen CR, Yan YT, Tsai ST, Chen CH,
Shen CN. Porphyrin homeostasis maintained by ABCG2 regulates
self-renewal of embryonic stem cells. PLoS One 2008 Dec; 3(12):
e4023. Epub 2008 Dec 24. SCI=4.351 (12.32%)
5.
Liu HL, Hsu PH, Chu PC, Wai YY, Chen JC, Shen CR, Yen TC,
Wang JJ. Magnetic resonance imaging enhanced by
superparamagnetic iron oxide particles: usefulness for distinguishing
between focused ultrasound-induced blood-brain barrier disruption
and brain hemorrhage. J Magn Reson Imaging 2009 Jan; 29(1):
31-38. SCI=2.777 (25.96%)
6.
Liu CL, Shen CR (equal to first), Hsu FF, Chen JK, Wu PT, Guo
SH, Lee WC, Yu FW, Mackey ZB, Turk J, Gross ML. Isolation and
identification of two novel SDS-resistant secreted chitinases from
Aeromonas schubertii. Biotechnol Prog 2009 Jan-Feb; 25(1):
124-131. SCI=2.398 (13.55%)
7.
Kang CJ, Chen YJ, Liao CT, Wang HM, Chang JT, Lin CY, Lee LY,
Wang TH, Yen TC, Shen CR, Chen IH, Chiu CC, Cheng AJ.
Transcriptome profiling and network pathway analysis of genes
associated with invasive phenotype in oral cancer. Cancer Lett 2009
284(2):131-140. Epub 2009 May 18. SCI=3.741 (31.51%)
8.
Yang CJ, Liu YK, Liu CL, Shen CN, Kuo ML, Su CC, Tseng CP, Yen
TC, Shen CR (correspondence). Inhibition of acidic mammalian
chitinase by RNA interference suppresses OVA-sensitized allergic
asthma. Hum Gene Ther 2009 Dec; 20(12): 1597- 1606. Epub 2010
Jun 23. SCI=4.202 (18.48%)
9.
Liu HL, Wai YY, Hsu PH, Lyu LA, Wu JS, Shen CR, Chen JC, Yen
TC, Wang JJ. In Vivo assessment of macrophage CNS infiltration
during disruption of the blood–brain barrier with focused ultrasound:
a magnetic resonance imaging study. J Cereb Blood Flow Metab
2010 Jan; 30(1): 177- 186. Epub 2009 Sep 2. SCI=5.457. (12.61%)
10. Shen CR, Chen, YS, Yang, CJ, Chen, JK, Liu CL. Colloid chitin
azure is a dispersible, low-cost, substrate for chitinase measurements
in a sensitive fast reproducible assay. J Biomol Screen 2010 Feb;
15(2): 213- 217. Epub 2009 Dec 30. SCI=2.395 (34.29%)
11. Tsai ZT, Wang JF, Kuo HY, Shen CR, Wang JJ, Yen TC. In situ
preparation of high relaxivity iron oxide nanoparticle with chitosan
coating aspotential MRI contrast agent and cell tracking agent. J
Magn Magn Mater 2010, 322: 208–213. SCI=1.204 (48.11%)
12. Wu SY, Hsieh CC, Wu RR, Susanto J, Liu TT, Shen CR, Chen Y, Su
CC, Chang FP, Chang HM, Tosh D, Shen CN. Differentiation of
pancreatic acinar cells to hepatocytes requires an intermediate cell
type. Gastroenterology 2010 Jun, 138(7): 2519-2530. Epub 2010 Feb
20. SCI=12.899 (1.54%)
13. Hsieh, CL, Liu, SJ, Shen, CR, Chen, MY, Hsu, SC., Tsai, JP., Li, YS.,
Yang, CJ. Chong P, Chen, HW. IL-6-tranfected tumor cells modulate
the status of CD8+ and CD4+ T cells to control the tumor growth.
Immunobiology 2010 Jun; 215(6): 486- 491. Epub 2009 Aug 19.
SCI=3.586 (28.90%)
14. Shih MF, Cheng YD, Shen CR, Cherng JY. A molecular
pharmacology study into the anti-inflammatory actions of Euphorbia
hirta L. on the LPS-induced RAW 264.7 cells through a selective
iNOS protein inhibition. J Natural Medicine 2010 Jul, 64(3): 330-5.
SCI=1.027 (76.09%)
15. Juang JH, Wang, JJ, Shen CR, Kuo CH, Chien YW, Kuo HY, Tsai
ZT, Yen TC. Magnetic resonance imaging of transplanted mouse
islets labeled with chitosan-coated Superparamagnetic iron oxide
nanoparticles. Transplant Proc 2010 Jul-Aug; 42(6): 2104- 2108.
SCI=0.994 (59.64%)
16. Cherng JY, Liu CC, Shen CR, Chen LY, Shih MF. Attenuation of
endotoxin and thermal injury-induced inflammatory effects by
Chlorella. Int J Immunopathol Pharmacol 2010 Jul-Sep;
23(3):811-820. SCI=3.061 (39.84%)
17. Liu YK, Yang CJ, Liu CL, Shen CR, Shiau LD. Using a fed-batch
culture strategy to enhance rAAV production in the baculovirus/insect
cell system. J Biosci Bioeng 2010 Aug; 110(2):187-193. Epub 2010
Mar 11. SCI=1.749 (27.11%)
18. Chen JK, Shen CR (equal to first), Liu CL. N-acetyl-glucosamine:
Production and Applications (invited review). Mar Drugs 2010 Sep
15;8(9):2493-2516. SCI=2.863 (34.78%)
19. Chang JT, Kuo TF, Chen YJ, Chiu CC, Lu YC, Li HF, Wang HM,
Shen CR, Cheng AJ. Highly potent and specific siRNAs against E6
or E7 genes of HPV16- or HPV18-infected cervical cancers. Cancer
Gene Ther 2010, Dec; 17(12):827-836. Epub 2010 Oct1. SCI=3.126
(27.33%)
20. Juang JH, Shen CR (equal to first), Wang, JJ, Kuo CH, Lin MY, Wu
ST, Tsai ZT, Yen TC. Magnetic resonance imaging study of mouse
islet allotransplantation. Transplant Proc 2010 Dec;42(10):4217-20.
SCI=0.994 (59.64%)
21. Chen JC, Ou LS, Chang ML, Chang PY, Muench MO, Shen CR,
Chang HL, Yu HY, Fu RH, Kuo ML. Characterization of tolerance
after in utero hematopoietic stem cell transplantation: the requirement
for a threshold level of chimerism to establish rather than maintain
postnatal skin tolerance. Cell Transplant 2010 Dec;19(12):1609-22.
Epub 2010 Aug 17. SCI=5.126 (8.33%)
22. Hwang YS, Shen CR, Chang SHL, Lai CC, Liu CL, Chen KJ, Lin
KK, Chen TL, Hsiao CH. The Validity of Clinical Feature Profiles for
Cytomegaloviral Anterior Segment Infection. Graefes Arch Clin Exp
Ophthalmol 2011Jan; 249:103–110 Epub 2010 Sep 21. SCI=2.102
(38.78%)
23. Chen JK, Shen CR (equal to first), Yeh CH, Fang BS, Huang TL,
Liu CL. N-acetyl Glucosamine Obtained from Chitin by Chitin
Degrading Factors in Chitinbacter tainanesis. Int J Mol Sci 2011 Feb;
12: 1187-1195. SCI=1.387(45.71%)
24. Shen CR (correspondence), Juang JH, Tsai ZT, Wu ST, Tsai FY,
Wang JJ, Yen TC. Preparation, characterization and application of
superparamagnetic
iron
oxide
encapsulated
with
N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride.
Carbohydr Polym 2011 Mar; 84(1): 781- 787. Epub 2010 Aug.
SCI=3.167(7.81%)
25. Lee MH, Chang JT, Yu FW, Shen CR (correspondence). The
prevalence of IL-17–producing cells in patients with Nasopharyngeal
carcinoma. J Biomed Lab Sci 2011 Mar; 23(1): 30-37.
26. Hsieh CL, Hsu SC, Shen CR, Chen MY, Liu SJ, Chong P, Chen HW.
Increased expression of IL-21 reduces tumor growth by modulating
the status of tumor-infiltrated lymphocytes. Immunobiology 2011
Apr; 216: 491–496. Epub 2010 Sep 15. SCI=3.586 (28.90%)
27. Shen CR, Wu ST, Tsai ZT, Wang JJ, Yen TC, Tsai JS, Liu CL.
Characterization of the Quaternized chitosan-stabilized iron-oxide
nanoparticles as a novel potential MRI contrast agent for cell
tracking. Poly International 2011Jun 60(6): 945 - 950.
SCI=3.167(28.95%)
28. Wang CH, Hwang YS, Chiang YS, Shen CR, Hsiue GH. Extended
release of Bevacizumab by thermosensitive biodegradable and
biocompatible hydrogel. Biomarcomolecules 2011 (in revision).
29. Chen JK, Shen CR (correspondence), Liu CL. Chitosan, the marine
functional food for a potent adsorbent of humic acid in the
gastrointestinal tract. Mar Drugs 2011 (in revision).