NURS 820 - Office of the Provost

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Department/Unit:Nursing-College of Health and Human Services Course Subject/Number:__Nurs 820____
Submitted by: Ana Stoehr___Ext:_34428__________ Email:[email protected]_______________________
Course Title
Human Genetics Concepts for Health Care______________________________________________
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GEORGE MASON UNIVERSITY
College of Health and Human Services
PhD/DNP in Nursing Program
NURS 820
Human Genetics Concepts for Health Care
Spring Semester 2008
Dr. Ann Maradiegue
School of Nursing
Office: Rob A489
Phone: (703) 993-1971
Fax: (703) 993-1942
E-Mail: [email protected]
Dr. Anna Baranova
(Molecular and Microbiology Department, CoS)
PWII 225C (A.B.)
Phone: (703) 993-4293
[email protected]
GEORGE MASON UNIVERSITY
College of Health and Human Services
NURS – 820 Human Genetic Concepts for NursesCourse Number:
Cross List: BIOL666 College of Science/ MMB
Course Title: Human Genetic Concepts for Health Care
Placement in Curriculum: Elective.
Course Description: The study of human genetics, principles of heredity and disease risks. (4:4:0).
Course Objectives:
Upon completion of the course, the student will:
1. Demonstrate integrated knowledge of genetic principles and frameworks
applicable to nursing, research, healthcare and/or health education.
2. Interpret outputs of research and laboratory methods used by geneticists.
3. Integrate selected genetic principles within the domains of nursing research, policy, practice and/or
education.
4. Analyze structure and function of the human genome.
5. Identify genetic risks for selected disease processes.
Teaching Strategies: Apply effective teaching/learning strategies and the skill of the critical thinking while
participating in peer professional evaluations.
Note: If you are a student with a disability and you need academic accommodations, please see instructor, and
contact the Disability Resource Center (DRC) at 708-993-2474. All academic accommodations must be
arranged through the DRC.
Required Texts:
Nussbaum, R.L., McInnes, R.R.& Willard, H.F. (2004). Thompson & Thompson: Genetics in Medicine, 6th ed.
Philadelphia: Saunders.
Recommended Texts:
Reece, R.J. (2004). Analysis of Genes and Genomes. Hoboken, N.J.: Wiley.
Young, I.D. (2005). Medical Genetics. New York: Oxford University Press
Other Texts:
Glass, D.J. (2007). Experimental Design for Biologists. Cold Spring Harbour Press.
Additional Readings: A list of journal publications by nurses working in the field of genetics is listed at the
endof this syllabus.
Course Requirements:
1. Open Book Exams (Mid-term and Final)
2. Lab Participation: Student must participate in the weekly lab exercises and activities. This includes field trips
to the Prince William campus to observe microarray facility, completion of lab safety courses, training in
genetic research methods and other exercises.
3. Written Paper: Each student should write a paper that meets their educational or research objectives; topic
will be pre-approved by the instructors. This document shall contain critical analysis of accumulated genetics–
related knowledge on the topic with an evaluation of the current genetic work in the field and future directions
for the genetics studies of the subject. Paper should be written according to the full APA reference format, or to
the format identified by the journal of choice.
4. Peer Evaluation: Each student is required to use their Mason email address to communicate with the
instructor and submit weekly journals. Students will also peer-evaluate the papers submitted by other students in
the class (each of the students will cross evaluate 3 papers of their classmates). The form for peer-evaluation
can be found at the end of the syllabus.
5. Website for honor code http://www.gmu.edu/facstaff/handbook/aD.html
Evaluation Methods:
Open Book Exams 30% (15% Mid-term, 15% Final exam)
Written Paper 30%
Peer Evaluations and Field work 15%
Lab 25%
Student Outcomes
The outcomes for the course are for the students to be able to identify, analyze and critically evaluate the
genetic principles, problems, questions, or issues as they pertain to the student’s research. Students will be
allowed the flexibility in their writing project to apply genetic principles to nursing education, practice or
research of student’s interest. The student course outcomes will be measured using three deliverables: written
papers, peer evaluations/lab experience. Lab experience will include exercises, field trips and hands on lab
when possible, that will constitute 25% of the final grade, respectively, and an open book exams will constitute
30% of the final grade.
Each week there will be a lecture on a molecular genetics concept, followed by a clinical example to explain the
concept. The lab experience will support and enhance the genetic concepts explained in class.
*Course Schedule
Activity
Week
WEEK Structure and function of human chromosomes. DNA replication,
1
recombination, crossing over
Example: Deletion síndromes, triploidy
Lab: Chromosomal maps
WEEK Concepts in Patterns of Inheritance; Gene Expression and Gene Penetrance,
2
function of gene tumor supressor
Example: Neurofibromatosis
Week
WEEK
3
WEEK
4
WEEK
5
WEEK
6
WEEK
7
WEEK
8
WEEK
9
WEEK
10
WEEK
11
WEEK
12
WEEK
13
WEEK
14
Activity
Lab: Pedigree Analysis
Introduction to critical thinking in genetics. Basic principles of the experimental
design and an analysis of experimental outcomes
Lab: Experimental design
Gene structure and function. Gene transcription, mRNA translation and
posttranslational modifications.
Examples: Mitochondrial disorders
Lab: DNA sequence analysis
Sources of the genetic information. (PubMed, OMIM, other).
Examples: Wilson’s Disease
This lab will be substituted by OLS training that will be given according to OLS
schedule. Students will be given dates to chose which date they can come for
training in accordance with OLS schedule.
Human Genome Project, its history and new projects. A short history lecture on
the one of the research methods (positional cloning)
Lab: Match the disease and candidate genes (educated guesswork)
Identifying genes for the Mendelian diseases. Heterozygotes and microsatellites
Example: Colon Cancer
Lab: Analysis of microsatellites in tumors samples as an aid for genetic
diagnosis
Field trip to PW campus
Lecture on PW campus on Transcriptome and Proteome profiling
Lab: write an analytical description of the particular research method based on
the equipment observed and its applicability to modern medicine
Polygenic inheritance and multifactorial diseases. Linkage, HAP Map,
haplotypes
Examples: Hirschspung’s disease and Hemochromatosis
Mid-term exam
Lab: Polygenic Inheritance models/use of concept maps
Interaction of genes and environment in complex diseases.
Examples: Factor V Leiden, Hypercholesterolemia, etc.
Lab: Twin studies
Research papers are due. Human polymorphisms, onset of the multifactorial
diseases and pharmacogenomics. (Guest Speaker, Travis O’Brien
Lab: Polymorphisms as predictors of the drug response
Famous examples: Wilson’s disease, tumor suppressor genes, obesity.
Lab: Association Studies
Population screening for carriers and genetic counseling. State laws for prenatal
testing.
Example: Cystic Fibrosis
Lab: Case analysis
Peer evaluations are due.
Ethical, legal and social issues in genetics.
Example: Huntington’s Disease
Lab: Case analysis
FINAL EXAM
FINAL
EXAM
WEEK
**The faculty reserves the right to alter the above schedule as necessary
Guidelines for Genetics Paper
The overall purpose of this assignment is for the doctoral student to explore genetic principles as they relate to
their program of research, nursing practice or nursing education. The paper should be no longer than 10-12
pages, double-spaced.
Objectives
At the end of this course the student will be able to:
1. Understand the implications of genetics for advancement of scholarship in health care disciplines.
2. Critically analyze published genetic works in their topic area.
3. Identify and interpret the genetic principles that are applicable to their subject of research and clearly link
these principles to their research interest in the written paper.
4. Make scientifically sound conclusions through articulation of genetic principles and outline future directions
for the research of their subject of interest.
Guidelines
1. A target journal and audience should be identified.
2. The Author’s Guidelines should be obtained for the target journal.
3. The style of the paper should conform to Author’s Guidelines of the selected journal.
4. The paper must reflect proper spelling, grammar, logical organization, and referencing.
5. In addition to the classic references related to the topic, current references must be used.
6. A cover letter to the editor of the target journal, as well as Grading Criteria for Human Genetics Paper
should be submitted with the paper.
7. The Honor Code must be upheld in the writing of the paper.
Sample Cover Letter
Date
Your address
Editor’s name and title
Editor’s address
Dear Dr./Ms. ------:
I have enclosed a manuscript for your consideration for the Journal of ------. The manuscript focuses on a topic
which I believe will be of special interest to your reader: ----. (Why you think they will want to publish your
article in their journal). I believe that my background in ------ and my expertise in ----- provide an appropriate
background for exploring this problem with your readers. (Why you are the one to write the article).
Thank you for your consideration of this manuscript. I look forward to hearing from you.
Sincerely,
(signature)
Your name, degrees and certifications
Grading Criteria for Human Genetic Paper
Name: ____________________________
____ Purpose for manuscript is clearly identified. (10 points)
____ A specific genetic problem is clearly described. (10 points)
____ Research and analytical writings provide appropriate background for understanding
the genetics of the problem. (10 points)
____ Exploration of topic reflects critical and creative thinking. (10 points)
____ Implications for readers of journal are addressed. (10 points)
____ Sources are cited appropriately to support claims. (10 points
____ Content of paper is organized clearly, with subsections and appropriate transition
between paragraphs and sections. (10 points)
____ Style and length of paper are appropriate for journal. (10 points)
____ Appropriate sentence structure, grammar, punctuation, spelling, and APA format
(or alternative style required by target journal) are used.
____Appropriate cover letter accompanies manuscript. (10 points)
0.0__________________________ 5 __________________________10
No evidence
Inconsistent evidence
Consistent evidence
Comments:
Table 2 Student Peer Evaluation Form
PEER REVIEW EVALUATION/CRITIQUE FORM
(20% of the grade)
(please write YOUR NAME at the bottom of every form your submitted)
Grading will be based on the Likert scale below with 0 being completely unclear and 10
being clearly articulated. Constructive explanations are an important part of the
evaluation.
1. Title of the written project evaluate/ Name of the author of the written project
2. Please evaluate scientific argumentation and logical clarity f this research paper.
Was the path of the logic of the author clear for you?
0 1 2 3 4 5 6 7 8 9 10
EXPLAIN the principle of your grading.
3. Please evaluate whether author of the project was able to EXPAND existing
scientific or societal concepts presented in the paper
0 1 2 3 4 5 6 7 8 9 10
EXPLAIN principle of your grading.
4.
Please evaluate whether you gained new genetics/genomics related knowledge
by reading this written project
0 1 2 3 4 5 6 7 8 9 10
EXPLAIN principle of your grading.
5. Please evaluate the total amount of work your fellow student did to prepare to
this presentation
0 1 2 3 4 5 6 7 8 9 10
EXPLAIN principle of your grading.
6. What were strong and weak sides of this project? (What are your
recommendations for writing/rewriting this paper?)
7. If you were a scientist starting further investigation of the topic presented today,
what would be your next steps?
PLEASE OUTLINE RESEARCH DIRECTIONS necessary for continuation of
the project.
If you think that the described research had some flaws/weak areas, please
INDICATE THE FLAWS/WEAK areas and propose the way how to fix them.
Examples of Published Nurses in Articles Related to Human Genetics
Edkins, R., Cheek, D. (2006). Pharmacogenetics. In M. Runge & C Patterson (Eds.),
Principles of molecular medicine (2nd ed.). Totowa, N.J.: Humana Press.
Beery, T. T. (2005). The genetics of cardiac arrhythmias. Biolological Research for
Nursing, 6 (4), 249-261.
Constantin, C.M. (2005). Genetics in Clinical Practice: a Team Approach. Journal of
Midwifery and Womens Health, 50(3), 252-253.
Constantin, C.M., Faucett, A., Lubin, I.M. (2005). A primer on genetic testing.
Journal of Midwifery and Womens Health, 50(3), 197-204.
Mansilla, M. A., Kimani, J., Mitchell, L.E., Christensen, K., Boomsma, D.I., Daack
Hirsch, S., et al. (2005). Discordant MZ twins with cleft lip and palate: a model for identifying genes in
complex traits. Twin Research and Human Genetics, 8 (1), 39-46.
Scott NM, Weinberg SM, Neiswanger, K., Daack-Hirsch, S., O'Brien, S., Murray, J.C.,
Marazita, M.L. (2005). Dermatoglyphic pattern types in subjects with nonsyndromic cleft lip with or
without cleft palate (CL/P) and their unaffected relatives in the Philippines. Cleft Palate Craniofacial
Journal, 42(4), 362-366.
Scott, N.M., Weinberg, S.M., Neiswanger, K., Brandon, C.A., Daack-Hirsch, S.,
Murray, J.C., Liu, Y.E., & Marazita, M.L. (2005). Dermatoglyphic fingerprint heterogeneity among
individuals with nonsyndromic cleft lip with or without cleft palate and their unaffected relatives in
China and the Philippines. Human Biology. 77(2), 257-266.
Vieira, A.R., Avila, J.R., Daack-Hirsch, S., Dragan, E., Felix, T.M., Rahimov, F.,
Harrington, J., Schultz, R.R., Watanabe, Y., Johnson, M., Fang, J. & O'brien, S.E., Orioli IM, Castilla
EE, Fitzpatrick DR, Jiang R, Marazita ML, Murray JC. (2005). Medical sequencing of candidate genes
for nonsyndromic cleft lip and palate. PLoS Genetics, 1(6), e64.
Graham, J. M., Jr., Gomez, M., Halberg, A., Earl, D. L., Kreutzman, J. T., Cui, J., et al.
(2005). Management of deformational plagiocephaly: repositioning versus orthotic therapy. Journal of
Pediatrics, 146 (2), 258-262.
Frazier, L., Johnson, R.L., & Sparks, E. (2005). Genomics and cardiovascular disease.
Journal of Nursing Scholarship, 37(4):315-321.
Giger, J.N., Strickland, O.L., Weaver, M., Taylor, H., & Acton, R.T. (2005). Genetic
predictors of coronary heart disease risk factors in premenopausal African-American women. Ethnicity
and Disease, 15(2):221-232.
Holston, E.C. (2005). Stigmatization in Alzheimer's disease research on African
American elders. Issues in Mental Health Nursing, 26(10):1103-1127.
Jacob, E., Beyer, J. E., Miaskowski, C., Savedra, M., Treadwell, M., & Styles, L.
(2005). Are there phases to the vaso-occlusive painful episode in sickle cell disease? Journal of Pain
and Symptom Management, 29 (4), 392-400.
Jacob, E., Miaskowski, C., Savedra, M., Beyer, J. E., Treadwell, M., & Styles, L.
(2005). Trends in complete blood count values during acute painful episodes in children with sickle cell
disease. Journal of Pediatric Oncology Nursing, 22 (3), 152-159.
Jacob, E., Miaskowski, C., Savedra, M, Beyer, J.E., Treadwell, M., Styles, L. (2006).
Changes in sleep, food intake, and activity levels during acute painful episodes in children with sickle
cell disease. Journal of Pediatric Nursing, 21 (1), 23-34.
Jamerson, P. A. (2005). The association between acute fatty liver of pregnancy and fatty
acid oxidation disorders. Journal of Obstetric Gynecologic and Neonatal Nursing 34 (1), 87-92.
Johnson, R.L., Williams, S.M. & Spruill, I.J. (2006). Genomics to health: Genomics,
nutrition, obesity, and diabetes. Journal of Nursing Scholarship, 38(1), 11-18. Keltner, N.L. (2005).
Genomic influences on schizophrenia-related neurotransmitter
systems. Journal of Nursing Scholarship, 37(4):322-328.
Letocha, A. D., Cintas, H. L., Troendle, J. F., Reynolds, J. C., Cann, C. E., Chernoff, E.
J., et al. (2005). Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta
confirms vertebral gains but not short-term functional improvement. Journal of Bone and Mineral
Research, 20 (6), 977-986.
Cabral, W. A., Makareeva, E., Colige, A., Letocha, A.D., Ty, J.M., Yeowell, H.N., et al.
(2005). Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/EhlersDanlos syndrome by interference with N-propeptide processing. Journal of Biological Chemistry, 280
(19), 19259-19269.
Maradiegue, A., Edwards, Q.T., Seibert, D., Macri, C., & Sitzer, L. (2005).
Knowledge, perceptions, and attitudes of advanced practice nursing students regarding medical genetics. Journal of the
American Academy Nurse Practitioners. (11):472-479.
McLemore, M. R., & Aouizerat, B. (2005). Introducing the MUC16 gene: implications
for prevention and early detection in epithelial ovarian cancer. Biological Research for Nursing, 6 (4), 262-267.
Axilbund, J.E., Hamby, L.A., Thompson, D.B., Olsen, S.J., & Griffin, C.A. (2005).
Assessment of the use and feasibility of video to supplement the genetic counseling process: a cancer genetic counseling
perspective. Journal of Genetic Counseling, 14(3), 235-243.
McLean, D. C., Jr., Spruill, I ., Argyropoulos, G., Page, G.P., Shiver, M.D., & Garvey,
W. T. (2005). Mitochondrial DNA (mtDNA) haplotypes reveal maternal population genetic affinities of Sea Island Gullahspeaking African Americans. American Journal Physical Anthropology, 127 (4), 427-438.
Tluczek, A., Koscik, R L., Farrell, P.M., & Rock, M. J. (2005). Psychosocial risk
associated with newborn screening for cystic fibrosis: parents' experience while awaiting the sweat-test appointment.
Pediatric, 115 (6), 1692-1703.
Dillard, J.P. & Tluczek, A.(2005). Information flow after a positive newborn screening
for cystic fibrosis. Journal of Pediatrics,147(3 Suppl):S94-97.
Kimmel, R.J., Kovacs, I.,Vrabel, C., Wood, B., Schalling, M., Kelsoe, J.R.
(2005).Cosegregation of bipolar disorder and autosomal-dominant medullary cystic kidney disease in a large family.
American Journal of Psychiatry, 162(10), 1972-1974.
Whitt, K.J. (2005). Experiences from the National Institute of Nursing Research:
Summer Genetics Institute 2004. Policy Politics and Nursing Practice, (1), 15-16.
Farina, L. & Winkelman, C. (2005). A review of the role of proinflammatory cytokines
in labor and noninfectious preterm labor. Biological Research for Nursing, 6 (3), 230-238.
Wung, S.F. & Merkle, C.J. (2005). BRCA1 genetic mutation and its link to ovarian
cancer: implications for advanced practice nurses. Journal of the American Academy of Nurse Practitioners, 17(12):518-526.
Beery, T. A. & Hern, M. J. (2004). Genetic practice, education, and research: an
overview for advanced practice nurses. Clinical Nurse Specialist, 18 (3), 126-32; quiz 133-134.
Beery, T. A. & Shooner, K. A. (2004). Family history: the first genetic screen. Nurse
Practitioner, 29 (11), 14-25.
Cashion, A. K., Driscoll, C. J., & Sabek. O. (2004). Emerging genetic technologies in
clinical and research settings. Biological Research for Nursing, 5 (3), 159-167.
Manthei, E. R., Siminerio, L.M., Conley, Y., Charron-Prochownik, D., Feathers, A.S.,
Charles, B., et al. (2004). Genetics and type 1 diabetes: online resources for diabetes educators. Diabetes Educator, 30 (6),
961-971.
Marazita, M. L., Murray, J.C., Lidral, A.C., Arcos-Burgos, M., Cooper, M.E., Goldstein,
T., Maher, B.S., Daack-Hirsch, S., et al. (2004). Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes
with novel loci on 9q21 and 2q32-35. American Journal of Human Genetics, 75 (2), 161-173.
Munger, R. G., Sauberlich, H. E., Vorvoran, C., Nepomucceno, B., Daack-Hirsch, S. &
Solon, F.S. et al. (2004). Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines. Birth
Defects Research Part A Clinical and Molecular Teratology, 70 (7), 464-471.
Schultz, R. E.,Cooper, M.E., Daack-Hirsch, S., Shi, M., Nepomuccena, B., Graf, K.A.,
et al. (2004). Targeted scan of fifteen regions for nonsyndromic cleft lip and palate in Filipino families. American Journal of
Medical Genetics Part A, 125 (1), 17-22.
Zucchero, T.M., Cooper, M.E., Maher, B.S., Daack-Hirsch, S., Nepomuceno, B.,
Ribeiro, L., et. al. (2004). Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. New
England Journal of Medicine, 351(8):769-780.
Dudley-Brown, S. (2004). The genetic family history assessment in gastroenterology
nursing practice. Gastroenterology Nursing, 27 (3), 107-110.
Dudley-Brown, S. (2004). A shot of good cholesterol: synthetic HDL, a new intervention
for atherosclerosis. Journal of Cardiovascular Nursing, 19 (6), 421-424.
Edwards, Q. T., Seibert, D., Macri, C., Covington, C., & Tilghman, J. (2004). Assessing
ethnicity in preconception counseling: genetics--what nurse practitioners need to know. Journal of American Academy of
Nurse Practitioners, 16 (11), 472-480.
Frazier, L., Meininger, J., Halsey, Lea D., & Boerwinkle, E. (2004). Genetic discoveries
and nursing implications for complex disease prevention and management.Journal of Professional Nursing, 20 (4), 222-2..
Frazier,L., Turner, S.T., Schwartz ,G.L., Chapman ,A.B., & Boerwinkle, E. (2004).
Multilocus effects of the renin-angiotensin-aldosterone system genes on blood pressure response to a thiazide diuretic.
Pharmacogenomics Journal. 4(1), 17-23.
Giger, J. N. (2004). Understanding genetics: the relationship of disease and genetic
predisposition in African-Americans. Journal of the National Black Nurses Association, 15(2), vii-viii.
Holston, E. C. & Schutte, D. L. (2004). The clinical utility of genetic information in the
care of persons with Alzheimer's disease. Medsurg Nursing, 13 (6), 415-419.
Hutson, S. P. & Loud, J. T. (2004). Cancer genetics resources: an organizational guide
for nurses and patients. Seminars in Oncology Nursing, 20 (3) 213-215.
Loud, J. T. & Hutson, S. P. (2004). The art and science of cancer nursing in the genomic
era. Seminars in Oncology Nursing, 20 (3), 143-144.
Jacob, E. (2004). Neuropathic pain in children with cancer. Journal of Pediatric
Oncology Nursing, 21 (6), 350-357.
Keltner, N. L. (2004). Summer Genetics Institute. Perspectives in Psychiatric Care 40
(4), 133-134.
Olsen, S., Dudley-Brown, S., & McMullen, P. (2004). Case for blending pedigrees,
genograms and ecomaps: nursing's contribution to the 'big picture'. Nursing and Health Sciences, 6 (4), 295-308.
Ramirez, C. T. & McKelvey, K.D. (2004). Genetics of Cardiovascular Diseases: an
Overview. Proceedings of the International Society of Nurse Geneticists Meeting.
Roscigno, C. I. (2004). Neuronal pathway finding: from neurons to initial neural
networks. Journal of Neuroscience Nursing, 36 (5), 263-272.
Spruill, I. (2004). Project Sugar: a recruitment model for successful African-American
participation in health research. Journal of the National Black Nurses Association, 15 (2), 48-53.
Horner, S. D., Abel, E., Taylor, K., & Sands, D. (2004). Using theory to guide
the diffusion of genetics content in nursing curricula. Nursing Outlook 52 (2), 80-84.
Markowitz, J. A., Tinkle, M.B., & Fischbeck, K. H. (2004). Spinal muscular atrophy
inthe neonate. Journal of Obstetric, Gynecologic and Neonatal Nursing, 33 (1), 12-20.
Twomey, J. G. (2004). Genetic testing of children: confluence or collision between
parents and professionals? AACN Clinical Issues, 13 (4), 557-566.
Winkelman, C. (2004). Genomics. What every critical care nurse needs to know about
the genetic contribution to critical illness. Critical Care Nurse., 24(3), 34-45.
Wung SF, Aouizerat BE. (2004). Newly mapped gene for thoracic aortic aneurysm and
dissection. Journal of Cardiovascular Nursing, 19(6), 409-16.
Beery, T., Dyment, M., Schooner, K., Knilans, T., & Benson, W. (2003). A candidate
locus approach identifies a long QT syndrome gene mutation. Biological Research in Nursing, 5 (2), 97-104.
Beery, T.A. (2003). Sex differences in infection and sepsis. Critical Care Nursing
Clinics North American, 15 (1), 55-62.
Cashion, A.K., & Driscoll, C.J. (2003). Genetics and kidney dysfunction. Nephrology
Nursing Journal, 31 (1), 14-18, 29 .
Velasquez-Mieyer, P.A., Cowan, P.A., Umpierrez, G.E., Lustig, R.H., Cashion, A.K., &
Burghen, G.A. (2003). Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during
oral glucose tolerance test in obese subjects. International Journal of Obesity Related Metabolic Disorders, 27 (11), 13591364.
Cheek, D.J., & Cesan, A. (2003). Genetic predictors of cardiovascular disease: the use of
chip technology. Journal of Cardiovascular Nursing, 18 (1), 505-506.
Jezewski, PA., Vieira, AR., Nishimura, C., Ludwig, B., Johnson, M., O'Brien, SE.,
Daack-Hirsch, S., et al. (2003). Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate. Journal
of Medical Genetics, 40 (6), 399-407.
Jezewski, PA., Vieira, AR., Nishimura, C., Ludwig, B., Johnson, M., O'Brien, SE.,
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